@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24460: (2016-07-08 )
MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGDKAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTYASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISEIAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYKGYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKGYGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIVITENGNRTITHSPKELIIL
Atome Classification :
(33 SA)
.........10........20....-----..-----..30...-.------.-----.------..40.--.....-..50----....---..-----...60--..--...--...-70......-..80.....--...90........100.......110.......120.......130.......140.......150.......160.......170.-....--..180.......190......---.200.......210.......220.......230........240......-.250......-----.260.......-------------270..----...--------------.-.-----280--.........290.......-..300--.......310.......320-----..---------..---....330.......340...-.----...350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
E
K
L
R
N
L
F
G
QLGI
D
G
M
L
I
TSNT
N
-----
V
R
-----
Y
M
TGFTG-S------A-----
G
------
L
A
V
IS--GD
K
A
A
-
F
I
T
-----
D
F
R
Y---T
E
-----
Q
A
K
V
Q
--
V
K
--
G
F
E
--
I
IE-HGGS
L
I
Q
T
-
T
A
D
T
V
E
SFG--
I
K
RLGFEQNSMTYGTYA
S
Y
S
A
VISDAELV
P
V
A
E
S
V
E
K
L
R
L
IKS
S
E
E
I
K
I
L
E
E
A
A
K
I
A
D
D
A
F
R
H
I
L
T
F
MKP
G
I
S
E
I
A
V
A
N
E
L
E
F
Y
M
RS-QGAD--SS
S
F
D
M
I
V
A
S
G
L
R
S
SLPHGVA---SDKLIESG
D
L
V
T
L
DF
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
VAV-GQ
P
S
D
Q
L
K
E
I
Y
Q
V
V
F
D
A
Q
-AL
G
V
A
HIKPG-----MTGK
E
A
D
A
L
T
R
-------------
D
H
I
AA----KGY--------------G-D-----Y----FGHSTGHGL
G
--
M
E
VHESP-GLSVR--SSAILEP
G
M
V
V
T
VEP
G
I
Y
I------PE---------TG---
G
V
R
I
ED
D
I
V
I
TENG
N
R
T
ITH-S----P
K
E
L
I
IL
1
PsiBlast_PDB
93.26
65%
-95
- C1 -
3Q6D
2
?
A:
[6-356]
-
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
G
-
T
------
A
-----
G
------
V
V
L
I
S
--
K
K
R
A
Q
-
F
I
T
-----
D
F
R
Y
---
V
E
-----
Q
A
S
K
Q
--
A
V
--
G
Y
E
--
I
V
Q
-
H
A
G
L
I
I
D
E
-
V
A
K
Q
V
K
E
L
G
--
I
Q
K
L
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
-
D
A
E
F
I
P
T
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
G
A
T
--
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
Q
-
L
R
G
V
N
G
I
K
A
G
-----
L
T
G
R
E
A
D
A
L
T
R
-------------
D
Y
I
T
E
----
K
G
Y
--------------
G
-
E
-----
Y
----
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
-
G
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
------
P
G
---------
I
G
---
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
T
K
-
S
----
P
K
E
L
I
I
L
21
PsiBlast_CBE
92.53
65%
-94
- C1 -
3Q6D
2
?
D:
[6-356]
-
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
G
-
T
------
A
-----
G
------
V
V
L
I
S
--
K
K
R
A
Q
-
F
I
T
-----
D
F
R
Y
---
V
E
-----
Q
A
S
K
Q
--
A
V
--
G
Y
E
--
I
V
Q
-
H
A
G
L
I
I
D
E
-
V
A
K
Q
V
K
E
L
G
--
I
Q
K
L
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
-
D
A
E
F
I
P
T
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
G
A
T
--
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
Q
-
L
R
G
V
N
G
I
K
A
G
-----
L
T
G
R
E
A
D
A
L
T
R
-------------
D
Y
I
T
E
----
K
G
Y
--------------
G
-
E
-----
Y
----
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
-
G
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
------
P
G
---------
I
G
---
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
T
K
-
S
----
P
K
E
L
I
I
L
23
PsiBlast_CBE
90.85
65%
-96
- C1 -
3Q6D
1
?
B:
[6-356]
-
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
G
-
T
------
A
-----
G
------
V
V
L
I
S
--
K
K
R
A
Q
-
F
I
T
-----
D
F
R
Y
---
V
E
-----
Q
A
S
K
Q
--
A
V
--
G
Y
E
--
I
V
Q
-
H
A
G
L
I
I
D
E
-
V
A
K
Q
V
K
E
L
G
--
I
Q
K
L
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
-
D
A
E
F
I
P
T
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
G
A
T
--
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
Q
-
L
R
G
V
N
G
I
K
A
G
-----
L
T
G
R
E
A
D
A
L
T
R
-------------
D
Y
I
T
E
----
K
G
Y
--------------
G
-
E
-----
Y
----
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
-
G
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
------
P
G
---------
I
G
---
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
T
K
-
S
----
P
K
E
L
I
I
L
22
PsiBlast_CBE
90.75
65%
-90
- C1 -
3Q6D
1
?
C:
[6-355]
-
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
G
-
T
------
A
-----
G
------
V
V
L
I
S
--
K
K
R
A
Q
-
F
I
T
-----
D
F
R
Y
---
V
E
-----
Q
A
S
K
Q
--
A
V
--
G
Y
E
--
I
V
Q
-
H
A
G
L
I
I
D
E
-
V
A
K
Q
V
K
E
L
G
--
I
Q
K
L
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
-
D
A
E
F
I
P
T
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
G
A
T
--
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
Q
-
L
R
G
V
N
G
I
K
A
G
-----
L
T
G
R
E
A
D
A
L
T
R
-------------
D
Y
I
T
E
----
K
G
Y
--------------
G
-
E
-----
Y
----
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
-
G
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
------
P
G
---------
I
G
---
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
T
K
-
S
----
P
K
E
L
I
I
-
48
HHSearch
77.01
64%
5
* C1 *
3Q6D
2
?
A:
[5-356]
E
K
I
E
R
L
R
S
A
F
D
E
A
G
I
D
G
I
L
L
T
N
E
H
S
-----
R
R
-----
Y
M
A
N
F
T
G
-
T
------
A
-----
G
------
V
V
L
I
S
--
K
K
R
A
Q
-
F
I
T
-----
D
F
R
Y
---
V
E
Q
----
A
S
K
Q
A
--
V
G
--
Y
E
I
--
V
---
Q
H
A
G
L
I
I
D
E
V
A
K
Q
V
K
E
L
G
--
I
Q
K
L
G
F
E
Q
D
T
L
T
Y
S
S
Y
S
A
H
K
E
A
I
D
-
A
E
F
I
P
T
S
G
L
V
E
K
L
R
L
I
K
T
D
S
E
I
K
I
L
K
E
A
A
Q
I
A
D
A
A
F
E
H
I
L
S
F
I
R
P
G
V
S
E
I
E
V
S
N
E
L
E
F
F
M
R
K
-
Q
G
A
T
--
S
S
S
F
D
I
I
V
A
S
G
L
R
S
A
L
P
H
G
V
A
---
S
E
K
V
I
E
T
G
D
F
V
T
L
D
F
G
A
Y
Y
K
G
Y
C
S
D
I
T
R
T
I
A
V
-
G
E
P
S
D
K
L
K
E
I
Y
N
I
V
L
E
A
Q
-
L
R
G
V
N
G
I
K
A
G
-----
L
T
G
R
E
A
D
A
L
T
R
-------------
D
Y
I
T
E
----
K
G
Y
--------------
G
-
E
-----
Y
----
F
G
H
S
T
G
H
G
I
G
--
L
E
I
H
E
A
P
-
G
L
A
F
R
--
S
D
T
V
L
E
P
G
M
A
V
T
V
E
P
G
I
Y
I
------
P
G
---------
I
G
---
G
V
R
I
E
D
D
I
I
V
T
S
E
G
N
E
V
I
T
K
-
S
----
P
K
E
L
I
I
L
2
PsiBlast_PDB
65.27
40%
37
- C1 -
2ZSG
8
?
A:
[5-359]
---
E
R
L
I
Q
L
I
S
E
E
G
I
D
A
F
L
I
M
N
I
E
N
-----
S
A
R
A
S
S
V
Y
F
S
G
F
T
G
-
S
------
F
-----
S
------
I
I
L
I
S
--
E
N
T
R
L
-
L
I
T
-----
D
S
R
Y
---
T
V
-----
Q
A
K
-
Q
--
E
T
--
D
F
E
--
V
R
E
V---
D
F
I
D
V
-
L
K
K
T
V
N
D
L
K
--
I
K
T
I
A
L
E
E
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
D
R
K
F
I
G
I
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
G
A
E
--
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
N
Y
C
A
D
I
T
R
V
V
S
I
-
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
Q
-
E
R
A
L
K
I
A
K
A
G
-----
V
T
G
K
L
L
D
S
V
A
R
-------------
E
F
I
R
E
----
K
G
Y
--------------
G
-
E
-----
F
----
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
-
A
I
S
F
R
--
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
------
E
G
---------
K
F
---
G
I
R
I
E
E
D
V
V
L
K
E
Q
G
C
E
I
L
T
T
-
L
----
P
R
S
I
F
V
V
49
HHSearch
64.04
39%
7
- C1 -
2ZSG
8
?
A:
[2-359]
D
R
S
E
R
L
I
Q
L
I
S
E
E
G
I
D
A
F
L
I
M
N
I
E
N
SA
R
A
S
S
V
-----
Y
F
S
G
F
T
G
-
S
------
F
-----
S
------
I
I
L
I
S
--
E
N
T
R
L
-
L
I
T
-----
D
S
R
Y
---
T
V
Q
----
A
K
Q
E
T
--
D
F
--
E
-
V
--
R
E
V
-----
D
F
I
D
V
L
K
K
T
V
N
D
L
K
--
I
K
T
I
A
L
E
E
E
R
V
S
L
S
L
F
R
R
I
S
S
A
F
G
D
R
K
F
I
G
I
D
D
E
V
K
Q
M
R
M
V
K
D
E
G
E
I
E
K
I
K
Q
A
I
E
I
S
E
R
A
F
L
E
T
V
Q
Q
I
R
A
G
M
T
E
K
E
I
A
A
L
L
E
Y
T
M
R
K
-
E
G
A
E
--
G
V
A
F
D
T
I
V
A
S
G
C
R
S
A
L
P
H
G
K
A
---
S
D
K
V
V
E
R
G
D
V
I
V
I
D
F
G
A
T
Y
E
N
Y
C
A
D
I
T
R
V
V
S
I
-
G
E
P
S
D
E
V
K
E
V
H
S
I
V
L
E
A
Q
-
E
R
A
L
K
I
A
K
A
G
-----
V
T
G
K
L
L
D
S
V
A
R
-------------
E
F
I
R
E
----
K
G
Y
--------------
G
-
E
-----
F
----
F
G
H
S
L
G
H
G
I
G
--
L
E
V
H
E
G
P
-
A
I
S
F
R
--
N
D
S
P
L
P
E
N
V
V
F
T
V
E
P
G
I
Y
L
------
E
G
---------
K
F
---
G
I
R
I
E
E
D
V
V
L
K
E
Q
G
C
E
I
L
T
T
-
L
----
P
R
S
I
F
V
V
54
HHSearch
63.46
43%
-2
- C1 -
1WY2
6
PEPQ_PYRHO
A:
[6-351]
E
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
N
-----
V
Y
-----
Y
I
S
G
A
S
P
-
L
------
A
G
----
G
------
Y
I
L
I
T
G-
E
S
A
T
L
-
Y
V
-------
P
E
L
---
E
Y
E
M
---
A
K
E
E
S
--
N
I
--
P
V
---
E
K
F
-
K
K
M
---
D
E
-
F
Y
K
A
L
E
--
G
--
I
K
S
L
G
I
E
S
-
S
L
P
Y
G
F
I
E
E
L
K
K
K
A
N
I
K
E
F
K
K
V
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
G
A
E
--
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
-
K
K
A
V
E
S
A
K
P
G
-----
I
T
A
K
E
L
D
S
I
A
R
-------------
N
I
I
A
E
----
Y
G
Y
--------------
G
-
E
-----
Y
----
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
-
R
V
S
Q
Y
--
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
------
P
K
---------
I
G
---
G
V
R
I
E
D
T
I
L
I
T
K
N
G
S
K
R
L
T
K
-
T
----
E
R
E
L
I
--
3
PsiBlast_PDB
63.13
43%
22
- C1 -
1WY2
6
PEPQ_PYRHO
A:
[7-351]
-
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
N
-----
V
Y
-----
Y
I
S
G
A
S
P
-
L
------
A
-----
G
G
-----
Y
I
L
I
T
--
G
E
S
A
T
L
Y
V
P
-----
E
L
E
Y
E
M
A
K
E
-----
E
S
N
I
P
--
V
E
--
K
F
K
--
K
M
D
-
E
F
Y
K
A
L
E
----------
G
--
I
K
S
L
G
I
E
-
S
S
L
P
Y
G
F
I
E
E
L
K
K
K
A
N
I
K
E
F
K
K
V
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
G
A
E
--
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
-
K
K
A
V
E
S
A
K
P
G
-----
I
T
A
K
E
L
D
S
I
A
R
-------------
N
I
I
A
E
----
Y
G
Y
--------------
G
-
E
-----
Y
----
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
-
R
V
S
Q
Y
--
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
------
P
K
---------
I
G
---
G
V
R
I
E
D
T
I
L
I
T
K
N
G
S
K
R
L
T
K
-
T
----
E
R
E
L
I
--
24
PsiBlast_CBE
62.86
43%
21
- C1 -
1WY2
3
PEPQ_PYRHO
B:
[7-351]
-
K
V
K
K
I
I
E
F
M
D
K
N
S
I
D
A
V
L
I
A
K
N
P
N
-----
V
Y
-----
Y
I
S
G
A
S
P
-
L
------
A
-----
G
G
-----
Y
I
L
I
T
--
G
E
S
A
T
L
Y
V
P
-----
E
L
E
Y
E
M
A
K
E
-----
E
S
N
I
P
--
V
E
--
K
F
K
--
K
M
D
-
E
F
Y
K
A
L
E
----------
G
--
I
K
S
L
G
I
E
-
S
S
L
P
Y
G
F
I
E
E
L
K
K
K
A
N
I
K
E
F
K
K
V
D
D
V
I
R
D
M
R
I
I
K
S
E
K
E
I
K
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
K
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
G
A
E
--
K
P
A
F
D
T
I
I
A
S
G
Y
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
Q
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
K
E
I
Y
E
I
V
L
E
A
Q
-
K
K
A
V
E
S
A
K
P
G
-----
I
T
A
K
E
L
D
S
I
A
R
-------------
N
I
I
A
E
----
Y
G
Y
--------------
G
-
E
-----
Y
----
F
N
H
S
L
G
H
G
V
G
--
L
E
V
H
E
W
P
-
R
V
S
Q
Y
--
D
E
T
V
L
R
E
G
M
V
I
T
I
E
P
G
I
Y
I
------
P
K
---------
I
G
---
G
V
R
I
E
D
T
I
L
I
T
K
N
G
S
K
R
L
T
K
-
T
----
E
R
E
L
I
--
70
Fugue
61.22
41%
-5
- C1 -
1PV9
2
PEPQ_PYRFU
A:
[8-345]
-----
L
V
K
F
M
D
E
N
S
I
D
R
V
F
I
A
K
P
V
N
-----
V
Y
-----
Y
F
S
G
T
S
P
-
L
------
G
-----
G
G
-----
Y
I
I
V
D
--
G
D
E
A
T
-
L
Y
V
-----
P
E
L
E
---
Y
E
-----
M
A
K
E
E
--
S
K
--
L
P
V
--
V
K
F
-
K
K
F
D
E
I
Y
E
-
I
L
K
N
T
E
T
L
G
--
I
------
E
G
T
L
S
Y
S
M
V
E
N
F
K
E
K
S
V
K
-
E
F
K
K
I
D
D
V
I
K
D
L
R
I
I
K
T
K
E
E
I
E
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
R
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
G
A
E
--
K
P
A
F
D
T
I
I
A
S
G
H
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
N
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
R
E
I
Y
E
I
V
L
E
A
Q
-
K
R
A
V
E
A
A
K
P
G
-----
M
T
A
K
E
L
D
S
I
A
R
-------------
E
I
I
K
E
----
Y
G
Y
--------------
G
-
D
-----
Y
----
F
I
H
S
L
G
H
G
V
G
--
L
E
I
H
E
W
P
-
R
I
S
Q
Y
--
D
E
T
V
L
K
E
G
M
V
I
T
I
E
P
G
I
Y
I
------
P
K
---------
L
G
---
G
V
R
I
E
D
T
V
L
I
T
E
N
G
A
K
R
L
T
K
-
T
----
E
R
-----
4
PsiBlast_PDB
61.22
41%
23
- C1 -
1PV9
2
PEPQ_PYRFU
A:
[8-345]
-----
L
V
K
F
M
D
E
N
S
I
D
R
V
F
I
A
K
P
V
N
-----
V
Y
-----
Y
F
S
G
T
S
P
L
G
------
G
-----
G
------
Y
I
I
V
D
--
G
D
E
A
T
L
Y
V
P
-----
E
L
E
Y
E
M
A
K
E
-----
E
S
K
L
P
--
V
V
--
K
F
K
--
K
F
D
-
E
I
Y
E
I
L
K
N
-
T
----
E
T
L
G
--
I
------
E
G
T
L
S
Y
S
M
V
E
N
F
K
E
K
S
-
V
K
E
F
K
K
I
D
D
V
I
K
D
L
R
I
I
K
T
K
E
E
I
E
I
I
E
K
A
C
E
I
A
D
K
A
V
M
A
A
I
E
E
I
T
E
G
K
R
E
R
E
V
A
A
K
V
E
Y
L
M
K
M
-
N
G
A
E
--
K
P
A
F
D
T
I
I
A
S
G
H
R
S
A
L
P
H
G
V
A
---
S
D
K
R
I
E
R
G
D
L
V
V
I
D
L
G
A
L
Y
N
H
Y
N
S
D
I
T
R
T
I
V
V
-
G
S
P
N
E
K
Q
R
E
I
Y
E
I
V
L
E
A
Q
-
K
R
A
V
E
A
A
K
P
G
-----
M
T
A
K
E
L
D
S
I
A
R
-------------
E
I
I
K
E
----
Y
G
Y
--------------
G
-
D
-----
Y
----
F
I
H
S
L
G
H
G
V
G
--
L
E
I
H
E
W
P
-
R
I
S
Q
Y
--
D
E
T
V
L
K
E
G
M
V
I
T
I
E
P
G
I
Y
I
------
P
K
---------
L
G
---
G
V
R
I
E
D
T
V
L
I
T
E
N
G
A
K
R
L
T
K
-
T
----
E
R
-----
5
PsiBlast_PDB
58.88
36%
18
- C1 -
1WN1
2
?
A:
[1-356]
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
L
-
H
------
E
----------------
V
--
G
E
R
L
A
-
I
L
A
V
S
AEG
D
Y
R
F
---
L
A
-----
P
S
L
Y
E
NV
V
N
--
N
F
P
A
T
F
W
H
-
D
G
E
N
P
Y
A
K
-
L
R
E
I
L
E
E
L
G
--
I
S
K
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
--
E
L
S
D
--
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
-
E
S
A
F
K
A
V
R
E
G
-----
I
K
A
K
D
V
D
S
R
A
R
-------------
E
V
I
S
K
----
A
G
Y
--------------
G
-
E
-----
Y
----
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
------
P
G
---------
L
G
---
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
T
K
-
A
----
E
R
E
L
I
I
L
53
HHSearch
58.10
38%
17
- C1 -
1WN1
2
?
A:
[1-356]
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
L
-
H
------
E
VGER
L
A
------
I
L
A
V
S
A-
E
G
D
Y
R
-
F
L
------
A
P
S
L
---
Y
E
N----
V
V
N
N
---
F
---
P
-
A
--
T
F
W
-
H
D
G
E
N
P
Y
A
K
L
R
E
I
L
E
E
L
G
IS
K
G
R
I
L
I
E
D
-
T
M
R
A
D
W
L
I
G
I
M
-
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
-
L
S
D
G
---
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
-
E
S
A
F
K
A
V
R
E
G
-----
I
K
A
K
D
V
D
S
R
A
R
-------------
E
V
I
S
K
----
A
G
Y
--------------
G
-
E
-----
Y
----
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
------
P
G
---------
L
G
---
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
T
K
-
A
----
E
R
E
L
I
I
L
25
PsiBlast_CBE
57.75
36%
18
- C1 -
1WN1
2
?
B:
[1-356]
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
L
-
H
------
E
----------------
V
--
G
E
R
L
A
-
I
L
A
VSAEG
D
Y
R
F
---
L
A
-----
P
S
L
Y
E
NV
V
N
--
N
F
P
AT
F
W
H
-
D
G
E
N
P
Y
A
K
-
L
R
E
I
L
E
E
L
G
--
I
S
K
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
--
E
L
S
D
--
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
-
E
S
A
F
K
A
V
R
E
G
-----
I
K
A
K
D
V
D
S
R
A
R
-------------
E
V
I
S
K
----
A
G
Y
--------------
G
-
E
-----
Y
----
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
------
P
G
---------
L
G
---
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
T
K
-
A
----
E
R
E
L
I
I
L
69
Fugue
57.56
38%
36
- C1 -
1WN1
2
?
A:
[1-356]
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
L
-
H
EVGER
L
A
-----
I
------
L
A
V
S
A
--
E
G
D
Y
R
-
F
L
A
-----
P
S
L
Y
---
E
N
-----
V
V
N
N
F
------
P
A
T
--
F
W
H
-
D
G
E
N
P
Y
A
K
-
L
R
E
I
L
E
E
L
G
--
I
S
K
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
E
-
L
-
S
D
--
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
-
E
S
A
F
K
A
V
R
E
G
-----
I
K
A
K
D
V
D
S
R
A
R
-------------
E
V
I
S
K
----
A
G
Y
--------------
G
-
E
-----
Y
----
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
------
P
G
---------
L
G
---
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
T
K
-
A
----
E
R
E
L
I
I
L
6
PsiBlast_PDB
57.45
36%
19
- C1 -
2HOW
-
?
A:
[1-356]
M
R
L
E
K
F
I
H
L
L
G
E
R
G
F
D
G
A
L
I
S
P
G
T
N
-----
L
Y
-----
Y
L
T
G
L
R
L
-
H
------
E
----------------
V
--
G
E
R
L
A
-
I
L
A
V
S
AEG
D
Y
R
F
---
L
A
-----
P
S
L
Y
E
NV
V
N
--
N
F
P
A
T
F
W
H
-
D
G
E
N
P
Y
A
K
-
L
R
E
I
L
E
E
L
G
--
I
S
K
G
R
I
L
I
E
D
T
M
R
A
D
W
L
I
G
I
M
K
L
G
K
F
T
F
Q
P
L
S
S
L
I
K
E
L
R
M
I
K
D
K
E
E
V
K
M
M
E
H
A
S
R
I
A
D
K
V
F
E
E
I
L
T
W
D
L
I
G
M
K
E
R
E
L
A
L
K
I
E
L
L
I
R
--
E
L
S
D
--
G
I
A
F
E
P
I
V
A
S
G
E
N
A
A
N
P
H
H
E
P
---
G
E
R
K
I
R
K
G
D
I
I
I
L
D
Y
G
A
R
W
K
G
Y
C
S
D
I
T
R
T
I
G
L
-
G
E
L
D
E
R
L
V
K
I
Y
E
V
V
K
D
A
Q
-
E
S
A
F
K
A
V
R
E
G
-----
I
K
A
K
D
V
D
S
R
A
R
-------------
E
V
I
S
K
----
A
G
Y
--------------
G
-
E
-----
Y
----
F
I
H
R
T
G
H
G
L
G
--
L
D
V
H
E
E
P
-
Y
I
G
P
D
--
G
E
V
I
L
K
N
G
M
T
F
T
I
E
P
G
I
Y
V
------
P
G
---------
L
G
---
G
V
R
I
E
D
D
I
V
V
D
E
G
K
G
R
R
L
T
K
-
A
----
E
R
E
L
I
I
L
50
HHSearch
55.31
35%
25
- C1 -
4FKC
9
?
A:
[17-377]
R
R
I
H
K
F
Q
A
H
F
G
K
K
G
F
E
G
A
L
V
A
P
G
S
N
-----
F
Y
-----
Y
L
T
G
F
N
P
-
L
------
G
TLER
L
F
------
V
L
I
L
P
S-
E
G
L
L
T
-
A
I
------
A
P
R
L
---
Y
E
-----
K
E
L
E
E
--
F
N
--
G
E
V
--
V
L
W
-
S
D
S
E
N
P
Y
K
I
F
A
T
K
I
K
E
T
F
KE
G
E
K
L
L
I
D
D
-
T
M
P
V
G
V
F
L
K
A
K
D
I
F
D
K
Y
S
L
H
P
I
S
P
V
I
S
E
L
R
E
I
K
D
K
D
E
I
K
A
H
K
K
A
A
E
I
V
D
K
V
F
Y
R
F
I
E
G
K
L
E
G
K
S
E
R
E
L
A
N
R
I
E
Y
M
I
K
N
E
F
G
A
D
--
D
V
S
F
E
P
I
V
A
S
G
P
N
G
A
N
P
H
H
R
P
---
S
H
R
K
I
R
K
G
D
V
V
I
F
D
Y
G
A
K
Y
L
G
Y
C
S
D
V
T
R
T
V
V
V
-
G
P
P
S
E
E
V
K
K
V
Y
E
I
V
K
E
A
Q
-
E
T
A
V
Q
K
V
A
E
G
-----
I
P
A
E
V
V
D
A
T
A
R
-------------
G
I
I
S
K
----
Y
G
Y
--------------
G
-
E
-----
Y
----
F
I
H
R
T
G
H
G
L
G
--
I
D
V
H
E
E
P
-
Y
I
S
P
G
--
N
K
K
I
L
K
D
G
M
V
F
T
I
E
P
G
I
Y
L
------
Q
G
---------
K
F
---
G
V
R
I
E
D
D
V
A
L
V
D
K
K
G
I
R
L
T
N
-
A
----
D
R
E
L
I
T
L
52
HHSearch
53.82
26%
-9
- C1 -
4R60
3
?
A:
[35-397]
Q
R
I
E
R
A
R
V
L
M
R
A
Q
G
V
D
A
L
L
I
G
A
G
T
S
-----
L
R
-----
Y
F
S
G
V
P
W
-
G
------
A
SE
R
L
-
V
------
A
L
L
L
T
TE
G
D
P
V
L
-
I
C
-------
P
A
F
---
E
E
G
----
S
L
D
A
V
--
L
Q
LP
V
R
K
--
R
L
W
-
E
E
H
E
D
P
Y
A
L
V
V
Q
A
M
D
E
Q
H
--
A
H
A
L
A
L
D
P
-
G
I
A
F
A
V
H
T
G
L
R
A
H
L
G
-
T
A
I
R
D
A
G
A
I
I
D
G
C
R
M
C
K
S
P
A
E
L
A
L
M
Q
Q
A
C
D
M
T
L
L
V
Q
R
L
A
A
G
I
A
H
E
G
I
G
T
D
Q
L
V
R
F
I
D
E
A
H
R
A
-
L
G
A
D
--
N
G
S
T
F
C
I
V
Q
F
G
H
A
T
A
F
P
H
G
I
P
---
G
V
Q
H
L
R
A
G
E
L
V
L
I
D
T
G
C
T
V
Q
G
Y
H
S
D
I
T
R
T
W
I
Y
-
G
T
P
S
D
A
Q
Q
R
I
W
E
L
E
L
A
A
Q
-
A
A
A
F
A
A
V
R
P
G
-----
V
A
C
E
A
V
D
Q
A
A
R
-------------
A
V
L
Q
A
----
A
G
L
--------------
G
-
P
DYRLP
G
----
L
P
H
R
T
G
H
G
C
G
--
L
A
I
H
E
A
P
-
Y
L
V
R
G
--
N
R
Q
P
L
Q
P
G
M
C
A
S
N
E
P
M
I
V
V
------
P
G
---------
A
F
---
G
V
R
L
E
D
H
F
Y
V
T
D
T
G
A
Q
W
F
T
P
-
P
----
S
V
A
I
D
Q
-
10
PsiBlast_PDB
52.18
28%
-0
- C1 -
4R60
3
?
A:
[36-389]
-
R
I
E
R
A
R
V
L
M
R
A
Q
G
V
D
A
L
L
I
G
A
G
T
S
-----
L
R
-----
Y
F
S
G
V
P
W
-
G
------
A
-----
S
E
R
L
V
A
L
L
L
T
T
E
--
G
D
P
V
L
-
I
C
P
-----
A
F
E
E
---
G
S
L
D
A
V
L
Q
L
P
V
R
--
K
R
--
L
W
E
--
E
H
E
-
D
P
Y
A
L
V
V
Q
-
A
M
D
E
Q
H
A
H
A
--
L
A
L
D
P
G
I
A
F
A
V
H
T
G
L
R
A
H
L
G
T
A
I
R
D
A
G
A
I
-----
I
D
G
C
R
M
C
K
S
P
A
E
L
A
L
M
Q
Q
A
C
D
M
T
L
L
V
Q
R
L
A
A
G
I
A
H
E
G
I
G
T
D
Q
L
V
R
F
I
D
E
A
H
R
A
-
L
G
A
D
--
N
G
S
T
F
C
I
V
Q
F
G
H
A
T
A
F
P
H
G
I
P
---
G
V
Q
H
L
R
A
G
E
L
V
L
I
D
T
G
C
T
V
Q
G
Y
H
S
D
I
T
R
T
W
I
Y
-
G
T
P
S
D
A
Q
Q
R
I
W
E
L
E
L
A
A
Q
-
A
A
A
F
A
A
V
R
P
G
-----
V
A
C
E
A
V
D
Q
A
A
R
-------------
A
V
L
Q
A
----
A
G
L
--------------
G
P
D
-----
Y
RLPG
L
P
H
R
T
G
H
G
C
G
--
L
A
I
H
E
A
P
-
Y
L
V
R
G
--
N
R
Q
P
L
Q
P
G
M
C
A
S
N
E
P
M
I
V
V
------
P
G
---------
A
F
---
G
V
R
L
E
D
H
F
Y
V
T
D
T
G
A
Q
W
F
T
--------------
66
HHSearch
50.55
36%
-28
- C1 -
2V3Z
3
AMPP_ECOLI
A:
[160-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
-----
T
S
I
L
E
V
T
G
E
V
V
-------------
R
I
M
V
S
G
L
V
K
L
G
I
LKG
D
V
D
E
L
I
A
QNAH
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
A
P
G
L
Y
I
------
A
P
DAEVPEQYR
G
I
---
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
S
V
----
V
K
K
P
E
E
-
15
PsiBlast_PDB
48.84
33%
-22
- C1 -
1WL6
6
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
38
PsiBlast_CBE
48.04
33%
-29
- C1 -
2BWT
4
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
A
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
20
PsiBlast_PDB
47.84
33%
-21
- C1 -
2BHD
5
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
27
PsiBlast_CBE
47.83
33%
-23
- C1 -
2BN7
7
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
34
PsiBlast_CBE
47.81
33%
-23
- C1 -
1A16
4
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
16
PsiBlast_PDB
47.45
33%
-22
- C1 -
1WLR
3
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
14
PsiBlast_PDB
47.29
33%
-20
- C1 -
1N51
3
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
28
PsiBlast_CBE
46.77
33%
-23
- C1 -
2BH3
7
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
17
PsiBlast_PDB
46.49
33%
-20
- C1 -
2BHA
3
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
40
PsiBlast_CBE
46.48
33%
-22
- C1 -
2BWW
5
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
A
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
18
PsiBlast_PDB
46.12
33%
-21
- C1 -
2BHB
6
AMPP_ECOLI
A:
[152-430]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
N
L
T
A
P
A
T
M
I
D
W
R
P
V
V
H
E
M
R
L
F
K
S
P
E
E
I
A
V
L
R
R
A
G
E
I
T
A
M
A
H
T
R
A
M
E
K
C
R
P
G
M
F
E
Y
H
L
E
G
E
I
H
H
E
F
N
R
-
H
G
A
R
--
Y
P
S
Y
N
T
I
V
G
S
G
E
N
G
C
I
L
H
Y
T
E
---
N
E
C
E
M
R
D
G
D
L
V
L
I
D
A
G
C
E
Y
K
G
Y
A
G
D
I
T
R
T
F
P
V
N
G
K
F
T
Q
A
Q
R
E
I
Y
D
I
V
L
E
S
L
-
E
T
S
L
R
L
Y
R
P
G
TS
I
L
E
V
T
G
E
V
V
R
I
M
V
S
G
L
V
K
L
GILKGD
V
D
E
L
I
A
Q
----
N
A
H
--------------
R
-
P
-----
F
----
F
M
H
G
L
S
H
W
L
G
--
L
D
V
H
D
V
G
-
V
Y
G
Q
D
--
R
S
R
I
L
E
P
G
M
V
L
T
V
E
P
G
L
Y
I
A
PDAEV
P
E
---------
Q
Y
RG
I
G
I
R
I
E
D
D
I
V
I
T
E
T
G
N
E
N
L
T
A
-
S
VVKK
P
E
E
I
---
45
PsiBlast_CBE
16.40
33%
25
- C1 -
3CTZ
5
XPP1_HUMAN
A:
[354-542]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
V
T
E
I
S
A
A
D
K
A
E
E
F
R
R
Q
-
Q
-
A
D
FV
D
L
S
F
P
T
I
S
S
T
G
P
T
G
A
I
I
H
Y
A
P
V
PE
T
N
R
T
L
S
L
D
E
V
Y
L
I
D
S
G
A
Q
Y
K
D
G
T
T
D
V
T
R
T
M
H
F
-
E
T
P
T
A
Y
E
K
E
C
F
T
Y
V
L
K
G
H
I
A
V
S
A
A
V
F
P
T
G
-----
T
K
G
H
L
L
D
S
F
A
R
-------------
S
A
L
W
D
----
S
G
L
----------------
D
-----
Y
----
L
-
H
G
T
G
H
G
V
G
SF
L
N
V
H
E
G
P
C
G
I
S
Y
K
TF
S
D
E
P
L
E
A
G
M
I
V
T
D
E
P
G
Y
Y
E
------
D
G
---------
A
F
---
G
I
R
I
E
N
V
V
L
V
-----------------------