@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29090: (2016-07-16 )
MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMILMKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQISRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVEFYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLESIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFKDLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEEPILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELKGAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEHLGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMGEELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLEKLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTDPNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTNDMDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFIDRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNTPIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVMEHALALDVPLKVDFASGPSWYDAK
Atome Classification :
(75 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......-430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630-.........640----.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.-......830.......840.......850.......-------860.......870.......880-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTE
R
K
K
L
V
L
VDGN
S
L
A
Y
R
A
F
F
ALPLLSNDKGVHT
N
A
V
Y
G
F
A
M
I
L
M
K
M
LEDEKP
T
H
M
L
V
A
FDAGKTTFRHG
T
F
K
E
YKGGRQKTP
P
E
L
S
E
Q
M
P
F
I
R
E
L
L
D
A
Y
Q
I
S
R
Y
E
L
E
QY
E
A
D
D
I
I
G
T
L
A
K
S
AEKDG
F
E
V
K
V
FSGD
K
D
L
T
Q
LATD
K
T
T
V
A
I
TRKGITD
V
E
FY
T
P
E
H
V
K
E
K
YGL
T
P
E
Q
I
I
D
M
K
GLMGDSSDNIPGVPGV
G
E
K
T
A
I
K
L
L
K
Q
F
D
S
V
E
K
L
L
E
S
I
D
E
VS
G
K
K
L
K
E
K
L
E
E
F
K
D
Q
A
L
M
S
K
E
L
A
T
I
MTDA
P
I
E
V
S
V
SGLEYQGF
N
R
E
Q
V
I
A
I
F
K
DL
G
F
N
T
L
L
E
R
LGEDSAE
A
E
QDQSLEDIN
V
K
T
V
TD-VTSDILVS
P
S
A
F
V
V
E
Q
IGDNYHEEP
I
L
G
F
S
I
VNETG
A
Y
FIPKDIA
V
E
S
E
V
F
K
E
W
V
ENDEQK
K
W
V
FDSK
R
A
V
V
A
L
R
W
Q
G
I
E
LKGA
E
F
D
T
L
L
A
A
Y
I
INPGN
S
Y
D
D
V
A
S
V
A
K
D
Y
G
L
H
I
VSSD-ESVYGKGAKRAVP
S
E
D
V
L
S
E
H
LG
R
K
A
L
A
I
Q
S
L
R
E
K
L
V
Q
E
LENN
D
Q
L
E
L
F
E
E
LEM
P
L
A
L
I
L
GEMESTG
V
K
V
D
V
D
R
L
K
R
M
G
E
E
L
G
A
K
L
K
E
Y
E
E
K
I
H
E
IAGEPFNINS
P
K
Q
L
G
V
I
L
F
E
KIGL
P
V
V
K
KTKTGYS
T
S
A
D
V
L
E
K
L
A
D
K
H
D
I
V
D
Y
I
L
Q
Y
R
Q
I
G
K
L
Q
S
T
Y
I
E
G
L
L
K
VTRPDS
H
K
V
H
T
R
F
N
Q
A
L
TQTGRLSSTDPNLQNI---
P
I
R
LEEG
R
K
I
R
Q
----
A
FVPSEK
D
W
L
I
F
AADY
S
Q
I
E
L
R
V
L
A
HISK
D
E
N
L
I
E
A
F
TNDMDIH
T
K
T
A
M
D
V
F
H
V
A
K
D
E
V
T
S
A
M
R
R
Q
AKAV
N
F
G
I
V
Y
GISDYGLSQNLGI
T
R
K
E
A
G
A
F
I
D
R
Y
L
E
S
F
Q
G
V
K
A
Y
M
E
D
S
V
Q
E
A
K
QK
G
Y
V
T
T
L
M
H
R
R
R
Y
I
P
E
L
TSRNF
N
I
R
S
F
A
E
R
TAMNTPIQG
S
A
A
D
I
I
K
K
A
M
I
D
M
A
A
K
L
K
E
K
Q
-
L
K
A
R
L
L
L
Q
V
H
D
E
L
I
FEA
P
K
E
E
I
E
I
L
E
K
L
V
P
E
V
M
E
H
A
-------LALDV
P
L
K
V
D
FASGPSWYDAK---
105
PsiBlast_CBE
89.64
66%
-110
- C4 -
4DQR
7
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
79
PsiBlast_CBE
89.44
66%
-107
- C4 -
4F2R
8
?
D:
[10-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
16
PsiBlast_PDB
89.44
67%
0
- C- -
3TAR
-
?
A:
[13--46]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
15
PsiBlast_PDB
89.44
67%
0
- C- -
3TAQ
-
?
A:
[13--34]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
14
PsiBlast_PDB
89.44
67%
0
- C- -
3TAP
-
?
A:
[13--32]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
13
PsiBlast_PDB
89.44
67%
0
- C- -
3TAN
-
?
A:
[13--26]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
38
PsiBlast_CBE
89.27
67%
-110
- C4 -
4DQP
6
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
77
PsiBlast_CBE
89.14
66%
-107
- C4 -
4F2S
6
?
D:
[10-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
107
PsiBlast_CBE
88.91
66%
-110
- C4 -
4DQQ
7
?
D:
[9-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
L
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
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Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
84
PsiBlast_CBE
88.91
66%
-106
- C4 -
4DSF
7
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
81
PsiBlast_CBE
88.90
66%
-107
- C4 -
4EZ9
4
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
74
PsiBlast_CBE
88.88
66%
-106
- C4 -
4F4K
7
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
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V
E
N
I
L
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Q
L
G
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Y
I
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L
L
K
V
V
R
P
A
T
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K
V
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I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
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V
L
A
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A
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D
D
N
L
M
E
A
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R
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L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
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T
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N
M
R
R
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A
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A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
40
PsiBlast_CBE
88.88
67%
-106
- C4 -
4DQI
5
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
86
PsiBlast_CBE
88.81
66%
-108
- C4 -
4DSE
7
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
82
PsiBlast_CBE
88.77
66%
-107
- C4 -
4EZ6
4
?
D:
[13-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
90
PsiBlast_CBE
88.70
66%
-104
- C4 -
3THV
6
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
92
PsiBlast_CBE
88.60
66%
-104
- C4 -
3PX6
6
?
D:
[12-592]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
76
PsiBlast_CBE
88.50
66%
-108
- C4 -
4F3O
6
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
94
PsiBlast_CBE
88.42
66%
-108
- C4 -
3PX4
6
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
88
PsiBlast_CBE
88.35
66%
-103
- C4 -
3TI0
5
?
D:
[14-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
34
PsiBlast_CBE
87.81
67%
-107
- C4 -
4DS5
5
?
D:
[12-592]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
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L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
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K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
36
PsiBlast_CBE
87.20
67%
-107
- C4 -
4DS4
5
?
D:
[12-592]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
M
A
F
T
L
A
D
R
-
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
67
PsiBlast_CBE
77.54
68%
16
- C4 -
1L3S
10
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
20
PsiBlast_PDB
77.43
68%
16
- C4 -
2HHQ
9
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
23
PsiBlast_CBE
77.11
68%
18
- C4 -
2HHV
10
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
21
PsiBlast_CBE
77.00
68%
18
- C4 -
2HW3
10
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
65
PsiBlast_CBE
76.99
68%
18
- C4 -
1L3U
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
49
PsiBlast_CBE
76.97
68%
18
- C4 -
1NKE
11
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
32
PsiBlast_CBE
76.91
68%
18
- C4 -
1U47
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
11
PsiBlast_PDB
76.90
69%
21
- C4 -
4B9V
9
?
A:
[45-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
100
PsiBlast_CBE
76.89
68%
16
- C4 -
3EYZ
6
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
56
PsiBlast_CBE
76.79
68%
16
- C4 -
1NK5
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
59
PsiBlast_CBE
76.76
68%
17
- C4 -
1NJZ
9
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
66
PsiBlast_CBE
76.74
68%
18
- C4 -
1L3T
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
12
PsiBlast_PDB
76.64
69%
16
- C4 -
2XY7
5
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
7
PsiBlast_PDB
76.63
69%
22
- C4 -
4B9N
9
?
A:
[45-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
63
PsiBlast_CBE
76.61
68%
19
- C4 -
1L5U
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
52
PsiBlast_CBE
76.59
68%
17
- C4 -
1NK9
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
55
PsiBlast_CBE
76.57
68%
16
- C4 -
1NK6
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
50
PsiBlast_CBE
76.57
68%
17
- C4 -
1NKC
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
29
PsiBlast_CBE
76.53
68%
19
- C4 -
1U4B
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
57
PsiBlast_CBE
76.52
68%
18
- C4 -
1NK4
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
26
PsiBlast_CBE
76.52
68%
18
- C4 -
2HHS
8
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
53
PsiBlast_CBE
76.50
68%
19
- C4 -
1NK8
9
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
30
PsiBlast_CBE
76.49
68%
19
- C4 -
1U49
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
24
PsiBlast_CBE
76.49
68%
18
- C4 -
2HHU
10
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
27
PsiBlast_CBE
76.48
68%
18
- C4 -
1UA1
6
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
54
PsiBlast_CBE
76.46
68%
15
- C4 -
1NK7
9
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
31
PsiBlast_CBE
76.45
68%
19
- C4 -
1U48
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
70
PsiBlast_CBE
76.44
68%
19
- C4 -
4DWI
12
?
A:
[7-581]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
25
PsiBlast_CBE
76.44
68%
17
- C4 -
2HHT
10
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
61
PsiBlast_CBE
76.43
68%
18
- C4 -
1NJX
9
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
58
PsiBlast_CBE
76.43
68%
20
- C4 -
1NK0
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
60
PsiBlast_CBE
76.42
68%
18
- C4 -
1NJY
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
8
PsiBlast_PDB
76.41
69%
21
- C4 -
4B9S
9
?
A:
[45-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
62
PsiBlast_CBE
76.38
68%
19
- C4 -
1NJW
8
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
51
PsiBlast_CBE
76.36
68%
19
- C4 -
1NKB
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
33
PsiBlast_CBE
76.32
68%
17
- C4 -
1U45
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
48
PsiBlast_CBE
76.22
68%
19
- C4 -
1XC9
9
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
64
PsiBlast_CBE
76.19
68%
16
- C4 -
1L3V
8
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
46
PsiBlast_CBE
76.11
68%
21
- C4 -
4O0I
11
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
71
PsiBlast_CBE
76.10
68%
19
- C4 -
4DSI
11
?
A:
[7-581]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
9
PsiBlast_PDB
76.08
69%
18
- C4 -
4B9T
5
?
A:
[45-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
10
PsiBlast_PDB
76.04
69%
20
- C4 -
4B9U
8
?
A:
[45-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
28
PsiBlast_CBE
75.85
68%
18
- C4 -
1UA0
6
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
22
PsiBlast_CBE
75.84
68%
16
- C4 -
2HHX
8
DPO1_BACCA
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
-----
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
19
PsiBlast_PDB
75.59
68%
20
- C4 -
2Y1J
4
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
43
PsiBlast_CBE
75.55
68%
18
- C4 -
4DSK
6
?
A:
[5-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
----
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
45
PsiBlast_CBE
75.36
68%
17
- C4 -
4DSJ
4
?
A:
[5-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
18
PsiBlast_PDB
75.20
68%
20
- C4 -
2Y1I
4
?
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
68
PsiBlast_CBE
75.14
68%
20
- C4 -
1LV5
6
DPO1_GEOSE
B:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
42
PsiBlast_CBE
75.06
68%
19
- C4 -
4DSL
4
?
A:
[5-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
44
PsiBlast_CBE
74.98
68%
16
- C4 -
4DSJ
2
?
B:
[5-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
----
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
69
PsiBlast_CBE
74.31
68%
22
- C4 -
1LV5
7
DPO1_GEOSE
A:
[6-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
-
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
K
I
R
Q
----
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
-
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
---
144
Fugue
62.27
32%
-14
- C4 -
4XVK
4
DPOLN_HUMAN
A:
[1-666]
---
K
K
H
F
C
D
I
R
H
L
D
-----------------------
D
W
A
K
S
Q
L
I
E
M
L
K
Q
A
A
A
L
V
I
T
V
M
Y
T
D
G
S
T
---------------------------------------------------------------------------
Q
L
G
A
D
Q
T
P
V
S
S
V
R
G
I
V
V
L
V
K
R
Q
A
C
G
P
V
L
E
G
F
--------------------------
V
S
D
D
P
C
I
Y
I
Q
I
E
H
S
A
I
W
D
-----------
Q
E
Q
E
A
H
Q
Q
F
A
R
N
V
L
F
----
Q
T
M
K
C
K
C
P
-----------------
V
I
C
F
N
A
K
D
F
V
R
I
V
L
Q
F
F
G
N
D
G
----------------------------
S
W
K
H
V
A
D
F
I
G
-------------------------------------------------------------------
L
D
P
R
I
A
A
W
L
I
D
P
S
D
A
T
P
S
F
E
D
L
V
E
K
Y
C
E
K
S
I
T
V
K
V
N
S
T
Y
G
N
------
S
S
R
N
I
V
N
Q
N
V
R
E
N
L
K
T
L
Y
R
L
T
M
D
L
C
S
K
L
K
D
Y
G
L
W
Q
L
F
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T
L
E
L
P
L
I
P
I
L
A
V
M
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S
H
A
I
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V
N
K
E
E
M
E
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T
S
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
G
E
R
F
L
I
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S
N
N
Q
L
R
E
I
L
F
G
K
L
K
L
H
L
L
S
Y
P
----
S
T
S
E
A
V
L
N
A
L
R
D
L
H
P
L
P
K
I
I
L
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Y
R
Q
V
H
K
I
K
S
T
F
V
D
G
L
L
A
C
M
K
K
G
--
S
I
S
S
T
W
N
Q
T
G
T
V
T
G
R
L
S
A
K
H
P
N
I
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G
I
SK
H
P
I
Q
I
T
T
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K
K
I
L
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PR
A
M
F
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S
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K
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A
A
D
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S
Q
I
E
L
R
I
L
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H
L
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G
D
P
E
L
L
K
L
D
----
D
V
F
S
T
L
T
S
Q
W
K
D
V
P
V
E
Q
V
T
H
A
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V
V
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A
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Y
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A
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A
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L
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L
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A
A
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L
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A
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L
L
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E
V
E
D
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Q
I
P
E
C
A
A
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R
R
T
M
E
S
L
EQVQALE
L
Q
L
Q
V
P
L
K
V
S
L
S
A
G
R
S
W
G
H
L
V
PLQ