@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34230: (2016-07-27 )
MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLAERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFIDSEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIEDAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQAREPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVRFMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFYSHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120..-....-.130.......140.......150.......160.......170.......180.......190.-.-..-...200.......210......-----.220-.--......230-.........240.......250.......260.......270--.----......280-.-..-.....290....------------.---------------------.--.---------------------.300--..---------.....310.......-320........330....--...340........350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MH
K
K
I
Y
LSPPHMSG
R
E
Q
H
Y
I
S
E
A
F
RSNWIA
P
L
G
P
L
V
N
S
F
E
E
Q
L
A
E
R
VGV
K
A
A
AAVGS
G
T
A
A
I
H
L
A
L
R
L
L
EVKEGD
S
V
F
C
Q
S
F
T
F
V
ATAN
P
I
L
YEKAV
P
V
F
IDSEPDTWNM
S
P
T
A
L
E
R
A
L
E
E
A
K
R-NGTL-
P
K
A
V
I
A
V
N
LYGQSA
K
M
D
E
I
V
S
L
C
D
AYGV
P
V
I
E
D
A
A
E
S
L
G
T
V
YKGKQSGTFG
R
F
G
I
F
S
FNG
N
K
I
I
T-T-SG-G
G
M
L
VSN
D
E
A
A
I
E
K
A
R
F
L
A
S
QA-----REP
A
-
V
--
H
Y
Q
H
SEI---GHN
Y
R
L
S
N
I
L
A
GV
G
I
A
Q
L
E
V
L
D
E
R
V
E
K
R
R
T
I
F
T
R
Y
K
N
A
LGHL--
D
----
G
V
R
F
M
P
E
Y
--A-AG-VSN
R
W
L
T
-
T
L
T
L------------D---------------------N--G---------------------L
S
P
Y
--
D
I
---------
V
Q
R
L
A
EENIEARPLW-K-PLHTQPLF
D
P
A
L
F
YSH--ED
T
G
-
S
V
C
E
D
L
F
KRGICLPSGSNMTEDEQ
G
R
V
I
E
V
L
L
H
L
F
H
T
V
E
V
K
K
W
TASIR
39
Fugue
92.44
47%
-79
- C1 -
1O69
3
?
A:
[12-385]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
E
-
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
------------
N
FDKNELNA
C
Q
K
D
I
N
I
S
Q
K
N
I
T
L
--
H
---------------------
P
K
I
S
--
K
L
---------
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
-------
G
N
S
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
K
S
I
K
------------
4
PsiBlast_PDB
91.87
45%
-72
- C1 -
4ZTC
1
PGLE_CAMJE
A:
[2-381]
---
R
F
F
L
S
P
P
H
M
G
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
A
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNS
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
T
M
H
A
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
49
HHSearch
91.84
47%
-76
- C1 -
1O69
3
?
A:
[12-385]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
E
-
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
----
C
E
K
K
-
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--
F
----
S
F
L
D
E
L
-
E
----
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
------------
N
---------------------
F
--
D
KNELNA
C
Q
K
D
I
N
I
S
Q
K
N
I
T
L
H
P
K
I
S
--
K
L
---------
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
------
A
Y
L
N
-
G
N
S
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
K
S
I
K
------------
3
PsiBlast_PDB
89.69
45%
-75
- C1 -
1O69
3
?
A:
[12-381]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNA
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
23
PsiBlast_CBE
88.38
45%
-72
- C1 -
1O61
7
?
B:
[12-381]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
------
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNA
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
1
PsiBlast_PDB
88.27
45%
-69
- C1 -
1O61
5
?
A:
[12-381]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNA
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
21
PsiBlast_CBE
87.64
45%
-71
- C1 -
1O69
4
?
B:
[12-381]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
------
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNA
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
22
PsiBlast_CBE
87.58
45%
-69
- C1 -
1O62
6
?
B:
[12-381]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
------
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNA
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
2
PsiBlast_PDB
87.44
45%
-68
- C1 -
1O62
5
?
A:
[12-381]
-------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
P
L
G
E
F
V
N
R
F
E
Q
S
V
K
D
Y
S
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
G
V
K
Q
D
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
C
E
K
-
K
----
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
-
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
-----
R
E
N
C
-
L
--
H
Y
E
H
L
D
Y
---
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
R
V
L
K
K
R
E
I
Y
E
W
Y
K
E
F
L
G
E
Y
--------
F
S
F
L
D
E
L
--
E
-
N
S
-
R
S
N
R
W
L
S
-
T
A
L
I
NFDKNELNA
C
Q
K
D
---------------------
I
--
N
---------------------
I
S
Q
K
--
N
I
T
L
H
P
K
I
S
K
L
I
E
D
L
K
N
K
Q
I
E
T
R
P
L
W
-
K
-
A
M
H
T
Q
E
V
F
K
G
A
K
A
Y
L
N
--
G
N
S
-----
E
L
F
F
Q
K
G
I
C
L
P
S
G
T
A
M
S
K
D
D
V
Y
E
I
S
K
L
I
L
----------------
55
HHSearch
85.56
36%
-91
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[28-390]
-----
S
V
A
A
P
R
L
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
V
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
-------
P
R
-
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
-
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
-----
M
D
P
N
-
R
--
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
-------
G
N
R
V
T
K
P
H
V
A
L
-
T
G
-
R
H
V
F
W
M
Y
-
T
V
R
L
------------
G
---------------------
E
--
G
LS-------------------
T
T
R
D
--
Q
V
---------
I
K
D
L
D
A
L
G
I
E
S
R
P
V
F
-
H
-
P
M
H
I
M
P
P
Y
A
H
L
A
------
T
D
D
L
-
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
-------------
25
PsiBlast_CBE
84.54
35%
-86
- C1 -
3DR4
2
GDPPS_CAUCR
C:
[26-386]
---
R
I
S
V
A
A
P
R
L
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
V
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
--------
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
-
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
-----
M
D
P
N
-
R
--
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
--
G
----
N
R
V
T
K
P
H
V
--
A
L
T
G
-
R
H
V
F
W
M
Y
-
T
V
R
L
------------
G
---------------------
E
--
G
---------------------
L
S
T
T
R
D
Q
V
---------
I
K
D
L
D
A
L
G
I
E
S
R
P
V
F
-
H
-
P
M
H
I
M
P
P
------
Y
A
H
LA
T
D
D
L
-
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
-----------------
26
PsiBlast_CBE
84.49
35%
-85
- C1 -
3DR4
4
GDPPS_CAUCR
B:
[26-386]
---
R
I
S
V
A
A
P
R
L
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
V
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
--------
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
-
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
-----
M
D
P
N
-
R
--
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
--
G
----
N
R
V
T
K
P
H
V
--
A
L
T
G
-
R
H
V
F
W
M
Y
-
T
V
R
L
------------
G
---------------------
E
--
G
---------------------
L
S
T
T
R
D
Q
V
---------
I
K
D
L
D
A
L
G
I
E
S
R
P
V
F
-
H
-
P
M
H
I
M
P
P
------
Y
A
H
LA
T
D
D
L
-
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
-----------------
24
PsiBlast_CBE
84.48
35%
-83
- C1 -
3DR4
2
GDPPS_CAUCR
D:
[26-386]
---
R
I
S
V
A
A
P
R
L
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
V
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
--------
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
-
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
-----
M
D
P
N
-
R
--
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
--
G
----
N
R
V
T
K
P
H
V
--
A
L
T
G
-
R
H
V
F
W
M
Y
-
T
V
R
L
------------
G
---------------------
E
--
G
---------------------
L
S
T
T
RD
Q
V
---------
I
K
D
L
D
A
L
G
I
E
S
R
P
V
F
-
H
-
P
M
H
I
M
P
P
------
Y
A
H
LA
T
D
D
L
-
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
-----------------
5
PsiBlast_PDB
83.75
35%
-83
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[28-386]
-----
S
V
A
A
P
R
L
D
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
S
V
G
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
G
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
--------
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
-
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
-----
M
D
P
N
-
R
--
R
Y
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
--
G
----
N
R
V
T
K
P
H
V
--
A
L
T
G
-
R
H
V
F
W
M
Y
-
T
V
R
L
------------
G
---------------------
E
--
G
---------------------
L
S
T
T
R
D
Q
V
---------
I
K
D
L
D
A
L
G
I
E
S
R
P
V
F
-
H
-
P
M
H
I
M
P
P
------
Y
A
H
LA
T
D
D
L
-
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
-----------------
63
HHSearch
81.90
30%
-80
- C1 -
1MDO
1
ARNB_SALTY
A:
[9-384]
--
D
F
L
P
F
S
R
P
A
M
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-
T
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
G
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
-------
P
Q
-
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
-
G
T
A
I
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
-
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
-----
L
G
V
D
----
Q
A
E
V
L
A
P
---
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
--
P
----
F
Q
P
L
S
L
P
S
--
W
-
E
H
-
I
H
A
W
H
L
F
-
I
I
R
V
------------
D
---------------------
E
--
A
RCG------------------
I
T
R
D
--
A
L
---------
M
A
S
L
K
T
K
G
I
G
T
G
L
H
F
-
R
-
A
A
H
T
Q
K
Y
Y
R
E
R
---
F
P
--
T
L
T
L
-
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
G
------------
10
PsiBlast_PDB
76.29
30%
-59
- C1 -
4ZAH
2
WECE_ECOLI
A:
[22-395]
----
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
D
K
T
R
--------
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
-
A
-
G
G
E
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
TNRSQ--------
K
Y
T
W
R
D
I
---
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
K
A
----
G
R
I
E
L
P
S
I
--
P
-
D
G
C
V
Q
N
A
H
M
F
-
Y
I
K
L
------------
R
---------------------
D
--
I
---------------------
D
D
R
S
--
A
L
---------
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
-
I
-
P
L
H
G
C
P
A
G
E
H
F
G
E
F
H
G
--
E
D
R
Y
-
T
T
K
E
S
--
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
-------------
64
HHSearch
76.06
28%
-55
- C1 -
4LC3
10
?
A:
[14-389]
-
A
P
F
L
P
F
T
R
P
E
I
D
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
-
T
T
G
P
Q
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
G
V
G
P
G
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
-------
P
R
-
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
-
T
-
I
E
-
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
-----
I
T
R
T
-
G
F
D
G
M
D
C
D
V
L
---
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
F
A
A
F
D
G
G
--
A
A
A
K
L
G
V
G
L
P
V
A
E
----
F
E
-
N
G
N
W
H
M
F
-
L
V
T
L
------------
P
---------------------
L
--
E
RLT------------------
I
T
R
A
--
E
F
---------
M
A
Q
M
K
E
R
G
I
G
T
G
I
H
Y
-
P
-
A
I
H
L
F
T
L
Y
R
A
R
G
F
--
K
--
E
G
M
F
-
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
C
E
Q
Y
----------
58
HHSearch
75.47
29%
-63
- C1 -
4ZAH
2
WECE_ECOLI
A:
[20-395]
--
H
M
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
-------
D
K
-
T
R
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
-
A
G
G
E
-
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
-----
T
N
R
S
Q---
K
Y
T
W
R
D
I
---
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
--
A
K
A
G-
R
I
E
L
P
S
I
P
--
D
-
G
C
-
V
Q
N
A
H
M
F
-
Y
I
K
L
------------
R
---------------------
D
--
I
---------------------
D
D
R
S
--
A
L
---------
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
-
I
-
P
L
H
G
C
P
A
G
E
H
F
G
E
--
F
--
H
G
E
D
-
R
Y
T
T
K
E
S
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
-------------
6
PsiBlast_PDB
72.89
33%
-34
- C1 -
4QGR
5
?
A:
[40-374]
-------------------------------
L
G
P
E
V
A
E
F
E
K
K
L
G
E
Y
L
G
V
E
H
V
I
A
C
A
N
G
T
D
A
L
Q
M
P
L
M
T
R
G
I
G
P
G
H
A
V
F
V
P
S
F
T
F
A
A
T
A
E
V
V
A
L
V
G
A
E
P
V
F
V
D
V
D
P
D
S
Y
N
M
N
V
E
Q
L
E
A
A
I
A
A
T
I
K
-
E
G
R
L
E
P
K
A
I
I
P
V
D
L
F
G
L
A
A
S
Y
N
R
I
T
A
I
A
E
R
E
G
L
F
I
I
E
D
A
A
Q
S
I
G
G
K
R
D
N
V
M
C
G
A
F
G
H
V
G
A
T
S
F
Y
P
A
K
P
L
G
-
C
-
Y
G
D
G
G
A
M
F
T
N
D
A
E
L
A
D
T
L
R
S
V
L
F
H
G
-----
K
G
-
E
-
T
--
Q
Y
D
N
V
R
I
---
G
I
N
S
R
L
D
T
I
Q
A
A
V
L
L
E
K
L
A
I
L
E
D
E
M
E
A
R
D
R
I
A
R
R
Y
N
E
A
---
L
--
K
----
D
V
V
K
V
P
E
L
--
P
-
A
G
-
N
R
S
A
W
A
Q
Y
S
I
E
S
------------
E
---------------------
N
R
D
G
---------------------
L
K
----------------
A
Q
L
Q
A
E
G
I
P
S
V
I
Y
Y
V
K
-
P
L
H
L
Q
T
A
Y
K
---
H
Y
S
V
--
A
P
G
G
L
P
V
S
E
S
L
P
S
R
I
L
S
L
P
M
H
P
Y
L
S
E
A
D
Q
D
K
I
I
G
V
I
-----------------
60
HHSearch
72.24
29%
-36
- C1 -
4QGR
5
?
A:
[17-381]
-------
Q
R
A
R
I
E
N
R
L
N
A
A
I
S
K
V
V
A
E
G
R
Y
I
-
L
G
P
E
V
A
E
F
E
K
K
L
G
E
Y
L
G
V
E
H
V
I
A
C
A
N
G
T
D
A
L
Q
M
P
L
M
T
R
G
I
G
P
G
H
A
V
F
V
P
S
F
T
F
A
A
T
A
E
V
V
A
L
V
G
A
E
P
V
F
V
D
V
D
P
D
S
Y
N
M
N
V
E
Q
L
E
A
A
I
A
A
T
I
K
E
G
R
L
E
-
P
K
A
I
I
P
V
D
L
F
G
L
A
A
S
Y
N
R
I
T
A
I
A
E
R
E
G
L
F
I
I
E
D
A
A
Q
S
I
G
G
K
R
D
N
V
M
C
G
A
F
G
H
V
G
A
T
S
F
Y
P
A
K
P
L
G
C
Y
-
G
D
-
G
G
A
M
F
T
N
D
A
E
L
A
D
T
L
R
S
V
L
F
H
G
-----
K
G
E
--
T
--
Q
Y
D
N
V
R
I
---
G
I
N
S
R
L
D
T
I
Q
A
A
V
L
L
E
K
L
A
I
L
E
D
E
M
E
A
R
D
R
I
A
R
R
Y
N
E
A
L
K
D
V
--
V
----
K
V
P
E
L
-
P
A
----
G
N
-
R
S
A
W
A
Q
Y
-
S
I
E
S
-----------------------------------------------------------
E
N
R
D
--
G
L
---------
K
A
Q
L
Q
A
E
G
I
P
S
V
I
Y
Y
-
V
K
P
L
H
L
Q
T
A
Y
K
H
Y
S
--
V
A
--
P
G
G
L
-
P
V
S
E
S
L
P
S
R
I
L
S
L
P
M
H
P
Y
L
S
E
A
D
Q
D
K
I
I
G
V
I
R
G
F
H
G
K
K
----------
27
PsiBlast_CBE
71.88
33%
-33
- C1 -
4QGR
4
?
B:
[40-374]
-------------------------------
L
G
P
E
V
A
E
F
E
K
K
L
G
E
Y
L
G
V
E
H
V
I
A
C
A
N
G
T
D
A
L
Q
M
P
L
M
T
R
G
I
G
P
G
H
A
V
F
V
P
S
F
T
F
A
A
T
A
E
V
V
A
L
V
G
A
E
P
V
F
V
D
V
D
P
D
S
Y
N
M
N
V
E
Q
L
E
A
A
I
A
A
T
I
K
-
E
G
R
L
E
P
K
A
I
I
P
V
D
L
F
G
L
A
A
S
Y
N
R
I
T
A
I
A
E
R
E
G
L
F
I
I
E
D
A
A
Q
S
I
G
G
K
R
D
N
V
M
C
G
A
F
G
H
V
G
A
T
S
F
Y
P
A
K
P
L
G
-
C
-
Y
G
D
G
G
A
M
F
T
N
D
A
E
L
A
D
T
L
R
S
V
L
F
H
G
-----
K
G
-
E
-
T
--
Q
Y
D
N
V
R
I
---
G
I
N
S
R
L
D
T
I
Q
A
A
V
L
L
E
K
L
A
I
L
E
D
E
M
E
A
R
D
R
I
A
R
R
Y
N
E
A
---
L
--
K
----
D
V
V
K
V
P
E
L
--
P
-
A
G
-
N
R
S
A
W
A
Q
Y
S
I
E
S
------------
E
---------------------
N
R
D
G
---------------------
L
K
----------------
A
Q
L
Q
A
E
G
I
P
S
V
I
Y
Y
V
K
-
P
L
H
L
Q
T
A
Y
K
---
H
Y
S
V
--
A
P
G
G
L
P
V
S
E
S
L
P
S
R
I
L
S
L
P
M
H
P
Y
L
S
E
A
D
Q
D
K
I
I
G
V
I
-----------------
18
PsiBlast_PDB
69.75
33%
-104
- C1 -
1MDZ
1
ARNB_SALTY
A:
[9-280]
--
D
F
L
P
F
S
R
P
A
M
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-
T
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
G
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
--------
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
-
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
LGVD------------
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.72
33%
-96
- C1 -
1MDX
4
ARNB_SALTY
A:
[9-280]
--
D
F
L
P
F
S
R
P
A
M
G
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-
T
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
G
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
--------
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
-
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L---------
G
--
R
A
P
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
62.38
33%
-81
- C1 -
3NU7
4
WBPE_PSEAE
B:
[33-290]
-------------------------------
L
G
P
E
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
R
T
--------
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
-
C
-
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
-----
Q
D
---
R
--
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
S
L
K
Q
V
--
G
I---
G
T
P
F
I
E
V
N
--
N
-
I
S
-
V
Y
A
Q
Y
---
T
V
R
M
------------
D
---------------------
N
----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.11
36%
-75
- C1 -
3FRK
2
?
A:
[25-260]
---------------------
E
I
Y
K
R
N
W
F
I
-
L
G
D
E
D
K
K
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
D
I
G
F
G
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
E
S
A
I
T
E
K
--------
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
-
S
-
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
I
K
A
L
S
N
Y
G
-----
S
E
K
K
-
Y
--
H
--
H
I
Y
K
---
G
F
N
S
R
L
D
E
L
Q
A
G
F
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.53
33%
-86
- C1 -
3NYT
1
WBPE_PSEAE
A:
[33-290]
-------------------------------
L
G
P
E
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
R
T
--------
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
-
C
-
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
-----
Q
D
---
R
--
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
S
L
K
Q
V
--
G
I---
G
T
P
F
I
E
V
N
--
N
-
I
S
-
V
Y
A
Q
Y
---
T
V
R
M
------------
D
---------------------
N
----------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.31
33%
-83
- C1 -
3NYS
1
WBPE_PSEAE
A:
[33-290]
-------------------------------
L
G
P
E
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
R
T
--------
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
-
C
-
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
-----
Q
D
---
R
--
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
S
L
K
Q
V
--
G
I---
G
T
P
F
I
E
V
N
--
N
-
I
S
-
V
Y
A
Q
Y
---
T
V
R
M
------------
D
---------------------
N
----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.25
33%
-85
- C1 -
3NU7
3
WBPE_PSEAE
A:
[33-290]
-------------------------------
L
G
P
E
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
R
T
--------
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
-
C
-
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
-----
Q
D
---
R
--
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
S
L
K
Q
V
--
G
I---
G
T
P
F
I
E
V
N
--
N
-
I
S
-
V
Y
A
Q
Y
---
T
V
R
M
------------
D
---------------------
N
----------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
61.24
36%
-74
- C1 -
3FRK
2
?
B:
[25-260]
---------------------
E
I
Y
K
R
N
W
F
I
-
L
G
D
E
D
K
K
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
D
I
G
F
G
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
E
S
A
I
T
E
K
--------
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
-
S
-
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
I
K
A
L
S
N
Y
G
-----
S
E
K
K
-
Y
--
H
--
H
I
Y
K
---
G
F
N
S
R
L
D
E
L
Q
A
G
F
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
60.77
33%
-82
- C1 -
3NUB
3
WBPE_PSEAE
B:
[33-290]
-------------------------------
L
G
P
E
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
G
V
G
P
G
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
R
T
--------
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
K
P
L
G
-
C
-
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
-----
Q
D
---
R
--
R
Y
H
H
I
R
V
---
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
S
L
K
Q
V
--
G
I---
G
T
P
F
I
E
V
N
--
N
-
I
S
-
V
Y
A
Q
Y
---
T
V
R
M
------------
D
---------------------
N
----------------------------------------------------------------------------------------------------------------------------------