@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35830: (2016-07-30 )
MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFTEGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLFRIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEAWRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDIKEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSASILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPAASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLTYPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAGKQQTVGT
Atome Classification :
(20 SA)
.........10........20........30------.....----..--------.--------------40-------------.....----.--------------..----.50..-----------......60........70........80......--..90--.------------------.------------------.---.....----------.100.......110.......120.......130.......140.......150......--------.--------.--------.160.......170.......180.......190.-.....-..200.......210.......----220--.--.----..----...----..230.-.-.-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390...------.------...400.......410.......420.......430.......440--.........450.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKQS
N
I
W
L
Y
F
F
G
ALG
G
A
L
YGYD
T
G
V
I
S
G
A
I
------
L
F
M
K
K
----EL--------G--------------
L
--------------
N
A
F
T
E
----
G
--------------
L
V
----
V
S
S
L
L
-----------
V
G
A
I
LGSGAAG
K
L
T
D
R
FGR
K
K
A
I
M
A
A
A
L
L
F
C
IGG--L
G
V
---A------------------L------------------A---PN
T
G
V
----------
M
V
L
F
R
I
I
L
G
LAVGTS
T
T
I
V
P
L
Y
L
S
E
LA
P
K
H
KR
G
A
L
S
S
L
N
Q
L
M
I
T
V
G
I
L
L
S
Y
I
--
V
N
Y
I
FA--------
D
--------
A
--------
E
A
W
R
W
M
L
G
L
A
A
V
P
S
L
L
L
L
I
G
I
L
FMPESP
R
W
L
F
-TN-G
E
E
S
K
-
A
K
K
I
L
E
K
LRGT
K
D
I
D
Q
E
I
H
D
I
K
----
E
----
A
--
E
----KQ----DEG----
G
L
K
E
L
F
-
D
-
P
-
W
V
R
P
A
L
I
A
G
L
G
L
A
F
L
Q
Q
F
IGTN
T
I
I
Y
YAPK
T
F
T
NVGFGNS
A
S
I
L
G
TV
G
I
G
T
V
N
V
L
M
T
L
V
A
I
K
I
I
D
K
IGRK
P
L
L
L
FGN
A
G
M
V
I
S
L
I
V
L
A
L
V
N
L
F
FDNTPAA
S
W
T
T
V
I
C
L
G
V
F
I
V
V
F
AVSWG
P
V
V
W
V
MLPELF
P
L
H
V
RGI
G
T
G
V
S
T
L
M
L
H
V
G
T
L
I
V
S
L
T
Y
P
I
------
L
------
M
E
A
I
G
I
S
Y
L
F
L
I
Y
A
A
I
G
I
M
A
F
L
F
V
R
F
K
V
TETKGR
S
L
E
E
I
E
Q
D
L
R----DKNGQGGAAGKQQTVGT
1
PsiBlast_PDB
79.04
51%
-156
- C1 -
4LDS
-
?
A:
[22-427]
----------------------
D
N
G
V
I
S
G
A
L
------
L
F
I
H
K
----
D
I
--------
P
--------------
L
--------------
N
S
T
T
E
----
G
--------------
I
V
----
V
S
S
M
L
-----------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
--
L
I
L
---
A
------------------
A
------------------
S
---
T
N
L
A
L
----------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
--
V
N
Y
A
F
A
--------
D
--------
I
--------
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
L
-
E
N
-
R
N
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
----
E
----
I
--
N
----
A
I
----
S
E
S
----
T
W
T
V
I
K
-
S
-
P
-
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
-
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
--------------------------------
21
HHSearch
79.01
52%
-148
- C1 -
4LDS
-
?
A:
[7-410]
-------
L
I
F
I
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
------
L
F
I
H
K
----
D
I
--------
P
--------------
L
--------------
N
S
T
T
E
----
G
--------------
I
V
----
V
S
S
M
L
-----------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
--
L
I
L
---
A
------------------
A
------------------
S
---
T
N
L
A
L
----------
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
--
V
N
Y
A
F
A
--------
D
--------
I
--------
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
L
-
E
N
-
R
N
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
----
E
-------
I
----
N
A
----
I
S
E
----
S
T
W
T
V
I
-
K
S
P
-
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
-
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
-------------------------------------------------
42
Fugue
76.61
35%
-113
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
------
E
S
L
N
T
----
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
----
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
--------
R
--------
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
--
L
----
D
H
----
G
R
K
----
T
G
G
R
L
L
-
M
-
F
-
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
----
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------
7
PsiBlast_PDB
75.15
30%
-89
- C1 -
4ZW9
4
GTR3_HUMAN
A:
[41-492]
--------------
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
----
F
I
--------
T
--------------
K
--------------
T
L
T
D
K
----
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
----
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
F
M
---
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
--------
E
--------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
----
D
----
E
--
S
A
R
M
S
Q
E
----
K
Q
V
----
T
V
L
E
L
F
-
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
--
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H-----------------
25
HHSearch
74.42
31%
-94
- C1 -
4PYP
1
GTR1_HUMAN
A:
[19-455]
------------
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
------
K
V
I
E
E
----
F
Y
--------
T
--------------
Q
T
W
V
H
R
YG
E
S
I
L
P
T
T
L
T
T
L
W
----
S
--------------
L
S
----
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
--
V
L
M
---
G
------------------
F
------------------
S
KLG
K
S
F
E
M
----------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
--
F
G
L
D
S
I
MG------
N
--------
K
--------
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
N
E
E
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
----
M
--
M
----
R
E
----
K
K
V
----
T
I
L
E
L
F
-
R
S
P
-
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
P
-
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
----------------------------------
8
PsiBlast_PDB
74.14
30%
-87
- C1 -
4ZWB
1
GTR3_HUMAN
A:
[41-492]
--------------
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
----
F
I
--------
T
--------------
K
--------------
T
L
T
D
K
----
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
----
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
F
M
---
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
--------
E
--------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
----
D
----
E
--
S
A
R
M
S
Q
E
----
K
Q
V
----
T
V
L
E
L
F
-
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
--
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H-----------------
9
PsiBlast_PDB
73.12
30%
-87
- C1 -
4ZWC
3
GTR3_HUMAN
A:
[41-492]
--------------
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
----
F
I
--------
T
--------------
K
--------------
T
L
T
D
K
----
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
----
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
F
M
---
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
--------
E
--------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
----
D
----
E
--
S
A
R
M
S
Q
E
----
K
Q
V
----
T
V
L
E
L
F
-
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
--
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H-----------------
6
PsiBlast_PDB
72.77
30%
-90
- C1 -
4PYP
1
GTR1_HUMAN
A:
[21-455]
--------------
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
------
K
V
I
E
E
F
Y
T
-
Q
T
--------
W
--------------
V
--------------
H
R
Y
G
E
----
S
--------------
I
L
----
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
---
S
K-----------------
L
------------------
G
---
K
S
F
E
M
----------
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
--------
N
--------
K
--------
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
N
E
E
N
R
-
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
----
E
----
E
--
S
----
R
Q
MMRE
K
K
V
----
T
I
L
E
L
F
R
S
-
P
-
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
--
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
-
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
----------------------------------
4
PsiBlast_PDB
72.76
34%
-100
- C1 -
4GC0
5
XYLE_ECOLI
A:
[19-475]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
L
L
--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
WPELGFTS----------
I
------------------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
L
D
H
----
G
R
----
K
T
G
----
G
R
L
L
M
F
-
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
-------------------------
3
PsiBlast_PDB
72.42
34%
-99
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[19-475]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
L
L
--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
W
PELGFTS----------
I
------------------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
L
D
H
----
G
R
----
K
T
G
----
G
R
L
L
M
F
-
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
-------------------------
2
PsiBlast_PDB
71.59
34%
-100
- C1 -
4GBY
5
XYLE_ECOLI
A:
[19-475]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
L
L
--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
WPELGFTS----------
I
------------------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
R
SGD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
L
D
H
----
G
R
----
K
T
G
----
G
R
L
L
M
F
-
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
-------------------------
22
HHSearch
71.12
36%
-105
- C1 -
4GC0
4
XYLE_ECOLI
A:
[15-429]
----------
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
------
E
S
L
N
T
----
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
----
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
------------------
W
PELGFTSINPDNTVPVYL
A
---
G
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
--------
R
S
GD
A
S
W
L
N
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
--
L
----
D
H
----
G
R
K
----
T
G
G
R
L
L
-
M
---
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
--
T
--
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
-----------------------------------------------------------------------
10
PsiBlast_PDB
71.00
30%
-85
- C1 -
5C65
8
GTR3_HUMAN
A:
[19-469]
--------------
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
----
F
I
--------
Q
--------------
K
--------------
T
L
T
D
K
----
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
----
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
F
M
---
G
------------------
L
C
KV---------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
--------
E
--------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
K
E
E
E
N
-
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
----
D
----
E
--
S
A
R
M
S
Q
E
----
K
Q
V
----
T
V
L
E
L
F
-
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
---
R
----
A
F
E
G
Q
A
-----------
23
HHSearch
70.80
32%
-89
- C1 -
4ZW9
4
GTR3_HUMAN
A:
[36-452]
---------
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
------
K
I
I
K
E
----
F
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
--------------
L
T
S
L
W
----
S
--------------
L
S
----
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
F
M
---
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
----------
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
--
F
G
L
E
F
I
LG------
S
--------
E
--------
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
----
D
E
S
A
R
M
--
S
----
Q
E
----
K
Q
V
----
T
V
L
E
L
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
--
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
A
Y
----------------------------------------------------------
20
PsiBlast_CBE
69.13
34%
-101
- C1 -
4JA3
2
XYLE_ECOLI
B:
[19-471]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
L
L
--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
WPELGF
T
S
----------
I
------------------
N
---
P
D
N
T
V
P
VYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
L
D
H
----
G
R
----------------------
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
---
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
KNS------------
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
-----------------------------
5
PsiBlast_PDB
68.08
34%
-107
- C1 -
4JA4
1
XYLE_ECOLI
A:
[19-475]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
L
L
--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
W
PELGF
T
S
----------
I
------------------
N
---
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
RSGD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
------
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
L
D
H
----
G
----------------
M
F
-
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
DKNSW------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
-------------------------
18
PsiBlast_CBE
67.71
34%
-101
- C1 -
4JA4
1
XYLE_ECOLI
C:
[19-475]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
ESLNTV
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
LL--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
WPELGFTS----------
I
------------------
N
---
P
--
T
V
PVYLAGYVPE
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
RSGDASWL
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
------
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
LD
H
----
G
----------------
M
F
-
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
MDKN---------------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
-------------------------
43
Fugue
67.61
36%
-118
- C1 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
---
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
------
E
S
L
N
T
V
FVA
P
Q
--------
N
--------------
L
--------------
S
E
S
A
A
N
S
L
L
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
----------
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
R
SGD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
T
--------------------
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
--
L
----
D
R
----------------
L
-
L
-
M
-
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
--
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
-----------------------------
19
PsiBlast_CBE
67.30
34%
-103
- C1 -
4JA4
1
XYLE_ECOLI
B:
[19-475]
--------------
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
----
N
L
--------
S
--------------
E
--------------
S
A
A
N
S
L
L
--
G
--------------
F
C
----
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
G
S
---
A
W
PELGF
T
S
----------
I
------------------
N
---
P
D
N
--PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
--
V
N
Y
F
I
A
RSGD
A
S
W
L
N
--------
T
--------
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
------
Q
E
Q
-
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
----
H
----
S
L
D
H
----
G
----------------
M
F
-
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
DKNSW------------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
-------------------------
11
PsiBlast_PDB
66.92
29%
-98
- C1 -
4YB9
-
GTR5_BOVIN
D:
[32-462]
-------------------
Y
G
Y
N
V
A
A
I
N
S
P
S
------
E
F
M
K
D
----
F
Y
--------
A
YTYYDRVGEY----
M
--------------
N
E
F
Y
L
----
T
--------------
L
L
WSVT
V
S
M
F
P
-----------
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
--
L
L
M
GFS
E
------------------
L
------------------
A
---
K
S
F
E
M
----------
I
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
FG
L
R
S
L
L
A
--------
N
--------
E
--------
E
G
W
P
I
L
L
G
L
T
G
I
P
A
V
L
Q
L
L
F
L
P
F
F
P
E
S
P
R
Y
L
L
I
Q
K
-
K
D
E
A
A
-
A
K
S
A
L
R
R
L
-------
A
E
I
E
E
I
L
----
E
----
E
--
D
----
R
A
----
E
K
A
VGFI
S
V
L
K
L
F
-
K
M
R
-
S
L
R
W
Q
V
I
S
I
I
V
L
M
A
G
Q
Q
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
G
V
N
E
D
D
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
F
S
V
C
F
T
A
C
C
V
L
T
G
A
L
A
L
Q
D
V
I
S
W
M
P
Y
V
S
I
A
C
V
I
S
Y
V
I
G
H
A
L
G
P
S
P
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
N
F
T
V
G
L
V
F
P
F
------
I
------
Q
V
G
L
G
-
A
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
I
I
P
E
-----------------------------------