@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0005: (2016-04-18 )
MGKNEARRSALAPDHGTVVCDPLRRLNRMHATPEESIRIVAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
Atome Classification :
(42 SA)
.........10........20........30........40........50........60........70......-.-.80........90........100-........110.--......120...-....130........140.......150.....-------..160.......170.......180.......-----190-..-...-.-...--200-.--.......210.-------......-220........230.......240.......250.......260.......270.......280.......290.......300-.......310.......320.......330....-...340........350.......360.......370.......380.......390.......400--..--.....410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610-.........620.......630.......640.......650.......660.......670.......680.......690.......700.......710..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGK
N
E
A
R
RSALAPDH
G
T
V
V
C
D
P
L
R
R
L
N
R
MHA
T
P
E
E
S
I
R
I
V
AAQKKKAQDEYGAA
S
I
T
I
L
E
G
L
E
A
V
R
KRP
G
M
Y
IGSTG-E-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
MAGY
A
--
T
T
V
N
V
V
L
LEDG
G
--
V
E
VADDGRG
I
P
V-ATHAS-GI
P
T
V
D
V
V
M
T
Q
L
HAGGKFDSD
A
Y
A
ISG-------GLH
G
V
G
V
S
V
V
N
A
LS
T
R
L
E
V
E
I
KRDGY
E
W
S
Q
V
Y-----E---KS-EPL-G-LKQ--GA--P--TKKTG
S
T
V
R
F
W-------ADP
A
V
F-ET-TEY
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
LNKG
L
T
I
N
LTDERV
T
Q
D
E
V
V
D
E
V
V
S
D
V
A
EAPK
S
A
S
E
RAAESTAPHKVKSRTFHYP
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
VDFSGKGTG
H
E
V
E
I
A
M
Q
WNAGY-S
E
S
V
-
H
T
F
A
N
TINTHEGG
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
LKDKDPNL
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
VS--EP--QFEGQTKTKLG
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
FEANPTD
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
L
V
R
RKSATDIGGLPGKLADCRSTDPRK
S
E
L
Y
V
V
EGDSAGGSAKS
G
R
D
S
M
F
Q
A
I
L
PLR
G
K
I
I
N
V
E
K
A
R
I
D
R
V
L
KN
T
E
V
Q
A
I
I
T
A
L
GTGIHDEFDIG
K
L
R
Y
H
K
I
V
L
M
ADADVD
G
Q
H
I
S
T
L
L
L
T
L
L
F
R
F
M
R
P
L
IENG
H
V
F
LAQPP
L
Y
K
L
---
K
WQRSDPEFAYSDRERD
G
L
L
E
A
G
L
K
AGKKI
N
K
E
D
G
I
Q
R
Y
KGLGEM
D
A
K
E
L
W
E
TTM
D
P
S
V
R
V
L
R
Q
VTLDD
A
A
A
A
D
E
L
F
S
I
L
MGE
D
V
D
A
R
R
S
F
I
TRNAK
D
V
R
FLDV
111
HHSearch
82.42
50%
-88
- C4 -
4I3H
2
?
A:
[24-647]
---------------------------------------------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
G
S
--
L
T
V
Q
D
H
----------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
-----
E
---
N
G
G
K
P
V
-
T
T
L
K
K
--
I
G
TA
P
--
K
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
--------------------------------
E
A
I
E
F
H
Y
E
N
G
V
Q
D
F
V
S
Y
-
L
N
E
D
K
E
I
L
-
T
P
V
L
Y
F
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
-
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
EE
H
L
--
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
---------------
G
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
---
S
K
G
----
A
Y
A
W
-
D
G
E
L
E
E
L
R
---------------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
------
3
PsiBlast_PDB
81.61
46%
-90
- C4 -
4I3H
2
?
A:
[24-646]
---------------------------------------------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
G
S
--
L
T
V
Q
D
H
----------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
-----
E
---
N
G
G
K
P
V
-
T
T
L
K
K
IG
T
A
--
P
--
K
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
E
A
I
E
------------------------------
F
H
Y
E
N
G
V
Q
D
F
V
S
Y
-
L
N
E
D
K
E
-
I
L
T
P
V
L
Y
F
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
-
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
--
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
---------------
G
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
KG-------
A
Y
A
W
-
D
G
E
L
E
E
L
R
---------------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
-------
4
PsiBlast_PDB
81.48
46%
-92
- C4 -
4JUO
4
PARE_STRPN
C:
[47-661]
---------------------------------------------------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
-----
D
R
I
D
V
T
I
N
K
D
G
S
--
L
T
V
Q
D
H
----------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
-----
E
---
N
G
G
K
P
V
-
T
T
L
K
K
IG
T
A
--
P
--
K
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
E
A
I
E
------------------------------
F
H
Y
E
--
V
Q
D
F
V
S
Y
-
L
N
E
D
K
E
-
I
L
T
P
V
L
Y
F
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
-
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
--
E
E
HL
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-----------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
-------
K
-------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
-------
40
PsiBlast_CBE
76.68
100%
-75
- C3 -
3ZKB
3
GYRB_MYCTU
D:
[12-427]
---------------------------------------------
K
A
Q
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
------------------------
S
T
A
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
76.17
100%
-74
- C3 -
3ZKB
4
GYRB_MYCTU
B:
[15-429]
------------------------------------------------
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
---------------------------------
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.13
100%
-81
- C3 -
3ZKD
3
GYRB_MYCTU
G:
[15-425]
------------------------------------------------
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-----------------------------
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.00
100%
-73
- C3 -
3ZKD
3
GYRB_MYCTU
H:
[17-426]
--------------------------------------------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
-----------------------------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.97
100%
-74
- C3 -
3ZKD
3
GYRB_MYCTU
D:
[16-428]
-------------------------------------------------
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-------------------------------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
---
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
75.49
100%
-76
- C3 -
3ZKB
4
GYRB_MYCTU
C:
[16-430]
-------------------------------------------------
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
----------------------------
A
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.83
100%
-74
- C3 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
--------------------------------------------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
D
E
------------------
R
A
A
E
S
T
A
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.81
100%
-77
- C3 -
3ZKD
3
GYRB_MYCTU
E:
[17-427]
--------------------------------------------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
---------------------------
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
74.26
100%
-77
- C3 -
3ZKB
3
GYRB_MYCTU
A:
[16-428]
-------------------------------------------------
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
------------------------------
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.26
100%
-77
- C3 -
3ZKB
3
GYRB_MYCTU
A:
[16-428]
-------------------------------------------------
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
------------------------------
P
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.10
100%
-74
- C3 -
3ZKD
3
GYRB_MYCTU
A:
[17-429]
--------------------------------------------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
-------------------------------
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
-----
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.08
100%
-77
- C3 -
3ZKD
3
GYRB_MYCTU
F:
[15-426]
------------------------------------------------
D
E
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
------------------------------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.72
100%
-82
- C3 -
3ZM7
2
GYRB_MYCTU
E:
[37-437]
-------------------------------------------------------------
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
---------------------------
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
----------------------------------
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
--
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.68
100%
-83
- C3 -
3ZM7
2
GYRB_MYCTU
C:
[36-436]
------------------------------------------------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
--------------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------------------------------
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
--
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.20
100%
-75
- C3 -
3ZKD
3
GYRB_MYCTU
B:
[17-425]
--------------------------------------------------
Y
G
A
A
S
I
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
--
T
T
V
N
V
V
L
L
E
D
G
G
--
V
E
V
A
D
D
G
R
G
I
P
V
-
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
-----
E
---
K
S
-
E
P
L
-
G
-
L
K
Q
--
G
A
--
P
--
T
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
------------------------------
H
K
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
-
I
N
R
T
K
N
A
I
H
S
S
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
-
H
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
----
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
--
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.47
100%
-92
- C4 -
5BTN
2
?
B:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
R
R
K
------
G
L
P
G
K
L
A
D
C
R
S
T
D
P
R
K
S
E
L
Y
V
V
E
G
D
S
A
G
G
S
A
K
S
G
R
D
S
M
F
Q
A
I
L
P
L
R
G
K
I
I
N
V
E
K
A
R
I
D
R
V
L
K
N
T
E
V
Q
A
I
I
T
A
L
G
T
G
I
H
D
E
F
D
I
G
K
L
R
Y
H
K
I
V
L
M
A
D
A
D
V
D
G
Q
H
I
S
T
L
L
L
T
L
L
F
R
F
M
R
P
L
I
E
N
G
H
V
F
L
A
Q
P
P
L
Y
K
L
---
K
W
Q
R
S
D
P
E
F
A
Y
S
D
R
E
R
D
G
L
L
E
A
G
L
K
A
G
K
K
I
N
K
E
D
G
I
Q
R
Y
K
G
L
G
E
M
D
A
K
E
L
W
E
T
T
M
D
P
S
V
R
V
L
R
Q
V
T
L
D
D
A
A
A
A
D
E
L
F
S
I
L
M
G
E
D
V
D
A
R
R
S
F
I
T
R
N
A
K
D
V
R
F
L
D
V
5
PsiBlast_PDB
62.33
100%
-95
- C4 -
5BS8
2
?
B:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
R
R
K
------
G
L
P
G
K
L
A
D
C
R
S
T
D
P
R
K
S
E
L
Y
V
V
E
G
D
S
A
G
G
S
A
K
S
G
R
D
S
M
F
Q
A
I
L
P
L
R
G
K
I
I
N
V
E
K
A
R
I
D
R
V
L
K
N
T
E
V
Q
A
I
I
T
A
L
G
T
G
I
H
D
E
F
D
I
G
K
L
R
Y
H
K
I
V
L
M
A
D
A
D
V
D
G
Q
H
I
S
T
L
L
L
T
L
L
F
R
F
M
R
P
L
I
E
N
G
H
V
F
L
A
Q
P
P
L
Y
K
L
---
K
W
Q
R
S
D
P
E
F
A
Y
S
D
R
E
R
D
G
L
L
E
A
G
L
K
A
G
K
K
I
N
K
E
D
G
I
Q
R
Y
K
G
L
G
E
M
D
A
K
E
L
W
E
T
T
M
D
P
S
V
R
V
L
R
Q
V
T
L
D
D
A
A
A
A
D
E
L
F
S
I
L
M
G
E
D
V
D
A
R
R
S
F
I
T
R
N
A
K
D
V
R
F
L
D
V
119
HHSearch
59.92
46%
-73
- C3 -
1KIJ
3
GYRB_THET8
A:
[7-388]
------------------------------------------------------
A
I
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
G
S
--
L
T
V
E
D
N
G
R
G
I
P
V
-
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
-----
S
---
R
G
-
E
V
T
-
E
P
L
R
V
--
V
G
EA
P
--
R
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
G
--------------------------------
K
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
-
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
-
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
--
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
59.84
50%
-67
- C3 -
4WUB
5
GYRB_ECOLI
A:
[3-390]
-------------------------------------------------
S
Y
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
S
--
V
S
V
Q
D
D
G
R
G
I
P
T
-
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
-----
E
---
H
G
-
V
P
Q
-
A
P
L
A
V
--
T
G
--
E
--
T
E
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
--------------------------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
-
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
--
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Fugue
59.68
49%
-63
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
-----------------------------------------------
S
N
S
S
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
S
--
V
S
V
Q
D
D
G
R
G
I
P
T
-
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
-----
E
---
H
G
-
V
P
Q
A
P
-
L
A
V
--
T
G
--
E
--
T
E
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
--------------------------------
D
G
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
-
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
--
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.22
43%
-72
- C3 -
1KIJ
3
GYRB_THET8
B:
[7-390]
------------------------------------------------------
A
I
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
G
S
--
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
-
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
SRG--
E
---
V
T
-
E
P
L
-
R
-
V
V
G
--
E
A
--
P
--
R
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
G
K
E
E
V
--------------------------------
F
L
D
K
G
G
V
A
S
F
A
K
A
-
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
-
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
--
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.95
43%
-76
- C3 -
1KIJ
3
GYRB_THET8
A:
[7-390]
------------------------------------------------------
A
I
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
--
T
E
I
L
V
R
L
N
E
D
G
S
--
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
-
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
RG--
E
---
V
T
-
E
P
L
-
R
-
V
V
G
--
E
A
--
P
--
R
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
G
K
E
E
V
--------------------------------
F
L
D
K
G
G
V
A
S
F
A
K
A
-
L
A
E
G
E
D
L
L
Y
E
K
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
-
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
--
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Fugue
58.75
49%
-65
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
-----------------------------------------------
S
N
S
S
D
S
S
S
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
S
--
V
S
V
Q
D
D
G
R
G
I
P
T
-
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
HG--
V
---
P
Q
-
A
P
L
-
A
-
V
T
G
--
E
T
------
E
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
--------------------------------
K
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
-
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
--
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.39
45%
-74
- C3 -
4ZVI
3
GYRB_ECOLI
A:
[1-361]
-------------------------------------------------------------
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
S
--
V
S
V
Q
D
D
G
R
G
I
P
T
-
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
--------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
-
G
K
I
H
R
Q
I
Y
-----
E
---
H
G
-
V
P
Q
-
A
P
L
A
V
--
T
G
--
E
--
T
E
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
E
D
--------------------------------
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
-
L
N
K
N
K
T
P
I
H
P
N
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
--
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
55.76
37%
-71
- C3 -
1S16
4
PARE_ECOLI
A:
[4-383]
-------------------------------------------------
T
Y
N
A
D
A
I
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
-----
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
Q
S
--
L
E
V
I
D
D
G
R
G
M
P
V
-
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
-----
E
---
N
G
-
E
K
V
-
Q
D
L
Q
V
--
V
G
--
T
CG
K
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
N
--------------------------------
T
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
-
A
V
N
G
L
P
T
L
P
E
K
P
F
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
-
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
-
R
G
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
--
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
54.44
36%
-71
- C3 -
4KQV
7
PARE_FRATH
A:
[7-380]
-----------------------------------------------------
K
S
I
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
S
--
I
E
V
A
D
D
G
R
G
M
P
V
-
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
-----------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
-----
E
DGF
K
T
-
K
D
L
-
E
-
I
I
D
--
N
V
--
G
--
K
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
--------------------------------
K
K
E
K
L
T
W
H
F
E
T
G
L
K
G
Y
L
D
H
K-----
L
P
A
E
P
F
I
I
D
N
F
S
N
G
D
S
Y
-
L
D
A
V
F
C
W
C
-----
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
-
E
K
N
S
L
S
V
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
--
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
I
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
53.61
36%
-70
- C3 -
4HYM
1
PARE_FRATH
A:
[7-377]
-----------------------------------------------------
K
S
I
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
S
--
I
E
V
A
D
D
G
R
G
M
P
V
-
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
------
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
-----
E
DGF
K
T
-
K
D
L
-
E
-
I
I
D
--
N
V
--
G
--
K
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
--------------------------------
K
K
E
K
L
T
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
T
L
P
A
E
P
F
I
I
D
N
F
S
N
G
D
S
Y
-
L
D
A
V
F
C
W
C
E
D
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
-
E
K
N
S
----
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
--
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
53.06
36%
-71
- C3 -
4HXZ
1
PARE_FRATH
A:
[8-381]
------------------------------------------------------
S
I
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
S
--
I
E
V
A
D
D
G
R
G
M
P
V
-
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-----------------
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
-----
E
DGF
K
T
-
K
D
L
-
E
-
I
I
D
--
N
V
--
G
--
K
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
--------------------------------
K
K
E
K
L
T
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
T
L
P
A
E
P
F
I
I
D
N
F
S
N
G
D
S
Y
-
L
D
A
V
F
C
W
C
E
D
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
-
E
K
N
S
L
S
V
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
--
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
I
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
48.13
79%
-84
- C3 -
4BAE
2
GYRB_MYCS2
B:
[4-194]
------------------------------------------------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
--
T
R
V
D
V
K
I
H
A
D
G
S
--
V
E
V
R
D
D
G
R
G
I
P
V
-
E
M
H
A
T
-
G
M
P
T
I
D
V
V
M
T
Q
L
-------------------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
Y
E
W
F
Q
Y
Y
-----
D
---
R
S
-
V
P
G
-
K
-
L
K
Q
--
G
G
--
E
--
T
K
E
T
G
T
T
I
R
F
W
-------
A
D
P
E
I
F
-
E
T
-
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
43.00
45%
-80
* C3 *
3FV5
1
PARE_ECOLI
A:
[1-194]
------------------------------------------------------------
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
-----
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
--
K
R
V
D
V
I
L
H
A
D
Q
S
--
L
E
V
I
D
D
G
R
G
M
P
V
-
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
----------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
-----
E
---
N
G
-
E
K
V
-
Q
D
L
Q
V
--
V
G
--
T
C
G
K
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
41.90
53%
-71
- C3 -
4DUH
1
GYRB_ECOLI
A:
[15-210]
------------------------------------------------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
--
K
E
I
I
V
T
I
H
A
D
N
S
--
V
S
V
Q
D
D
G
R
G
I
P
T
-
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
---------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
-----
E
---
H
G
-
V
P
Q
-
A
P
L
A
V
--
T
G
--
E
--
T
E
K
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
41.51
54%
-70
- C3 -
4K4O
2
GYRB_ENTFA
A:
[1-196]
------------------------------------------------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
--
K
S
I
Q
V
I
I
E
P
D
D
S
--
I
T
V
I
D
D
G
R
G
I
P
V
-
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
G
K
V
Y
Y
Q
E
Y
-----
R
---
R
G
-
A
V
V
-
D
D
L
K
V
--
I
E
--
E
--
T
D
R
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
-
T
E
T
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
41.33
72%
-68
- C3 -
4B6C
3
GYRB_MYCS2
B:
[30-185]
---------------------------------------------------------------------------
T
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
--
T
R
V
D
V
K
I
H
A
D
G
S
--
V
E
V
R
D
D
G
R
G
I
P
V
-
E
M
H
A
T
-
G
M
P
T
I
D
V
V
M
T
Q
---------------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
Y
E
W
F
Q
Y
Y
-----
D
---
R
S
-
V
P
G
-
K
-
L
K
Q
--
G
G
--
E
--
T
K
E
T
G
T
T
I
R
F
W
-------
A
D
P
E
I
F
-
E
T
-
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
41.07
54%
-65
- C3 -
4URO
1
GYRB_STAAU
A:
[26-219]
--------------------------------------------------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
W
--
I
K
V
T
D
N
G
R
G
I
P
V
-
D
I
Q
E
K
M
G
R
P
A
V
E
V
I
L
T
V
--------------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
-----
K
---
K
G
-
V
P
Q
-
F
D
L
K
E
--
V
G
--
T
--
T
D
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
40.45
51%
-63
- C3 -
5CPH
2
?
A:
[17-196]
----------------------------------------------------
A
G
Q
I
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
--
N
Q
I
E
V
V
I
E
K
D
N
W
--
I
K
V
T
D
N
G
R
G
I
P
V
-
D
I
Q
E
K
--------
M
G
R
-
P
A
V
E
V
I
L
---------------------
T
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
-----
K
---
K
G
-
V
P
Q
-
F
D
L
K
E
--
V
G
--
T
--
T
D
K
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
39.52
36%
-80
- C3 -
4HY1
1
PARE_FRATH
B:
[8-271]
------------------------------------------------------
S
I
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
S
--
I
E
V
A
D
D
G
R
G
M
P
V
-
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
-----
E
DGF
K
T
-
K
D
L
-
E
-
I
I
D
--
N
V
--
G
--
K
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
--------------------------------
K
K
E
K
L
T
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
-
A
E
T
L
P
A
E
------------------------
P
-
S
E
S
I
K
N
S
Y
V
N
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Fugue
37.69
48%
-76
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-219]
--------------------------------------------
S
N
S
S
D
S
S
S
I
K
---
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
--HC
K
E
I
I
V
T
I
H
A
--
D
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
-
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-------NSYKVSG
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
HG
V
---
P
Q
-
A
P
L
-
A
-
V
T
G
--
E
T
------
E
K
T
G
T
M
V
R
F
W
P
SLETFT-------
N
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-
K
R
D
--
G
K
E
D
H
F
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
37.19
36%
-71
- C3 -
4KQV
2
PARE_FRATH
B:
[8-217]
------------------------------------------------------
S
I
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
--
S
K
I
N
I
T
L
Y
E
D
N
S
--
I
E
V
A
D
D
G
R
G
M
P
V
-
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
---------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
-----
E
DGF
K
T
-
K
D
L
-
E
-
I
I
D
--
N
V
--
G
--
K
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
--------------------------------
K
K
E
K
L
T
W
H
F
E
T
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Fugue
30.76
47%
-40
- C3 -
1EI1
1
GYRB_ECOLI
A:
[220-391]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
K
A
F
V
E
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--
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T
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