@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0073: (2016-04-19 )
MGDLSIQNLVVEYYSGGYALRPINGLNLDVAAGSLVMLLGPSGCGKTTLLSCLGGILRPKSGAIKFDEVDITTLQGAELANYRRNKVGIVFQAFNLVPSLTAVENVMVPLRSAGMSRRASRRRAEELLARVNLAERMNHRPGDLSGGQQQRVAVARAIALDPPLILADEPTAHLDFIQVEEVLRLIRELADGERVVVVATHDSRMLPMADRVVELTPDFAETNRPPETVHLQAGEVLFEQSTMGDLIYVVSEGEFEIVHELADGGEELVKVAGPGDYFGEIGVLFHLPRSATVRARSDATAVGYTVQAFRERLGVGGLRDLIEHRALAND
Atome Classification :
(24 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10..-......20.----.......30........40........50........60........70.-------.......80..--......90........100....-.-..110-.-........120.......130---......-..140..----.-----------.....150.......160.......170.......180...-....190.-...-..-.200--------.-...-...210.--...-...220.......230.......240...---....250.....------..260.......270.......280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGD
L
S
I
Q
N
L
V
V
E
Y-YSG
G
Y
A
L
R
P----INGL
N
L
D
VAA
G
S
L
V
M
L
LGPSGC
G
K
T
T
L
L
S
C
L
G
G
I
LRPKSG
A
I
K
F
DE
V
D
I
T
-------
T
LQG
A
E
L
A
N
YR--RNK
V
G
I
V
F
Q
A
F
NLVP
S
L
T
A
V
E
N
V
-
M
-
V
P
L
---
R
-SAG
M
S
R
R
A
S
R
R
R
A
E
E
L
L
A
R
V
----
N
L
A
E
R
M-NHR-PGD----L-----------SGG
Q
Q
Q
R
V
A
V
A
R
A
IALDP
P
L
I
LADEPTA
H
L
D
F
I
Q
V
E
E
V
L
R
L
-
I
R
E
LADG
E
-
R
V
V
-
V
V
-ATHD--------S-RML-
P
M
A
D
R
V
V
--ELT-P
D
F
AETNRPP
E
T
V
H
LQAG
E
V
L
F
EQSTMG
D
---
L
I
Y
V
VSEG
E
F
E
I
------
V
H
E
L
ADG
G
E
E
L
V
K
VAGPGD
Y
F
GE
I
G
V
L
F
HLPRS
A
T
V
R
ARSDATAV
G
Y
T
V
Q
A
F
R
E
R
LGV
G
G
L
R
D
L
I
E
H
R
ALAND
22
PsiBlast_CBE
88.48
41%
-127
- C1 -
3TIF
7
Y796_METJA
B:
[2-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
K
N
V
T
K
T
Y
-
K
M
G
E
E
I
I
Y
A
----
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
L
D
D
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
-
L
P
L
IFK
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
----
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
-
V
V
-
V
T
H
D
--------
I
-
N
V
A
-
R
F
G
E
R
I
I
--
Y
L
-----------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.71
41%
-121
- C1 -
3TIF
7
Y796_METJA
A:
[2-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
K
N
V
T
K
T
Y
-
K
M
G
E
E
I
I
Y
A
----
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
L
D
D
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
-
L
P
L
IFK
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
----
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
-
V
V
-
V
T
H
D
--------
I
-
N
V
A
-
R
F
G
E
R
I
I
--
Y
L
-----------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.71
41%
-127
- C1 -
1L2T
4
Y796_METJA
B:
[2-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
N
V
T
K
T
Y
-
K
M
G
E
E
I
I
Y
A
----
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
L
D
D
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
-
L
P
L
IFK
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
----
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
-
V
V
-
V
T
H
D
--------
I
-
N
V
A
-
R
F
G
E
R
I
I
--
Y
L
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.36
41%
-121
- C1 -
1F3O
2
Y796_METJA
A:
[2-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
N
V
T
K
T
Y
-
K
M
G
E
E
I
I
Y
A
----
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
L
D
D
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
-
L
P
L
I
F
K
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
----
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
-
V
V
-
V
T
H
D
--------
I
-
N
V
A
-
R
F
G
E
R
I
I
--
Y
L
-----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.42
41%
-122
- C1 -
1L2T
4
Y796_METJA
A:
[2-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
N
V
T
K
T
Y
-
K
M
G
E
E
I
I
Y
A
----
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
L
D
D
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
-
L
P
L
IFK
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
----
E
L
E
E
R
F
A
N
H
K
-
P
N
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
-
V
V
-
V
T
H
D
--------
I
-
N
V
A
-
R
F
G
E
R
I
I
--
Y
L
-----------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
81.16
35%
-89
- C1 -
1Z47
1
?
A:
[11-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
--
A
R
S
----
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
------------
D
L
P
P
Q
K
--
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
-
S
-
F
G
L
---
R
-
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
----
R
L
E
S
Y
A
-
N
R
F
-
P
H
E
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
-
V
R
Q
V
H
D
E
M
-
G
V
T
S
V
F
-
V
T
H
D
--------
Q
E
E
A
L
-
E
V
A
D
R
V
L
--
V
L
H
-
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
-
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
------------------------------------------------------
118
Fugue
80.93
29%
-104
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRA
T
G
D
L
E
F
R
N
V
T
F
T
Y
---
P
G
R
E
V
P
A
----
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
-------
E
Y
T
L
A
S
L
R
N
------
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
-
A
----------
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
----
Y
A
M
D
F
I
-
N
K
M
-
D
N
G
----
L
D
T
I
I
G
ENGVLL
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
-
L
D
E
L
Q
K
N
R
-
T
S
L
-
V
I
-
A
-
H
R
--------
L
-
S
T
I
-
E
Q
A
D
E
I
V
--
V
V
E
------------------
D
G
I
I
V
E
R
G
T
H
S
E
---
L
L
A
Q
--
H
G
V
Y
A
Q
------
L
H
K
M
Q
F
G
------------------------------------------------------------------
58
PsiBlast_CBE
80.83
35%
-90
- C1 -
1Z47
1
?
B:
[14-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
--
A
R
S
----
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
------------
D
L
P
P
Q
K
--
R
N
-
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
-
S
-
F
G
L
---
R
-
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
----
R
L
E
S
Y
A
-
N
R
F
-
P
H
E
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
-
V
R
Q
V
H
D
E
M
-
G
V
T
S
V
F
-
V
T
H
D
--------
Q
E
E
A
L
-
E
V
A
D
R
V
L
--
V
L
H
-
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
-
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
------------------------------------------------------
8
PsiBlast_PDB
78.27
39%
-113
- C1 -
4YMW
-
?
J:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
MGFAREVG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.26
40%
-115
- C1 -
4U00
3
?
A:
[17-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
V
----
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
-------
D
D
R
A
--
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
-
A
P
M
---
R
-
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
-
R
K
Y
-
P
A
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
-
M
R
D
L
A
Q
G
G
-
M
T
M
-
V
V
-
V
T
H
E
--------
M
-
G
F
A
R
E
V
A
D
R
V
V
--
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
----------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.31
39%
-115
- C1 -
4YMU
2
?
A:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
M
G
F
A
R
E
VG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
77.28
40%
-116
- C1 -
4U02
1
?
C:
[17-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
V
----
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
-------
D
D
R
A
--
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
-
A
P
M
---
R
-
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
-
R
K
Y
-
P
A
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
-
M
R
D
L
A
Q
G
G
-
M
T
M
-
V
V
-
V
T
H
E
--------
M
-
G
F
A
R
E
V
A
D
R
V
V
--
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.28
39%
-111
- C1 -
4YMV
1
?
J:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
MGFAREVG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.27
40%
-114
- C1 -
4U02
1
?
D:
[17-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
V
----
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
-------
D
D
R
A
--
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
-
A
P
M
---
R
-
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
-
R
K
Y
-
P
A
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
-
M
R
D
L
A
Q
G
G
-
M
T
M
-
V
V
-
V
T
H
E
--------
M
-
G
F
A
R
E
V
A
D
R
V
V
--
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
----------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
77.17
40%
-113
- C1 -
4U02
1
?
B:
[17-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
V
----
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
-------
D
D
R
A
--
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
-
A
P
M
---
R
-
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
-
R
K
Y
-
P
A
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
-
M
R
D
L
A
Q
G
G
-
M
T
M
-
V
V
-
V
T
H
E
--------
M
-
G
F
A
R
E
V
A
D
R
V
V
--
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.04
39%
-116
- C1 -
4YMS
-
?
J:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
MGFAREVG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.57
39%
-111
- C1 -
4YMV
1
?
A:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
M
G
F
A
R
E
VG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.44
40%
-110
- C1 -
4U02
1
?
A:
[17-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
V
----
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
-------
D
D
R
A
--
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
-
A
P
M
---
R
-
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
-
R
K
Y
-
P
A
Q
----
L
-----------
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
-
M
R
D
L
A
Q
G
G
-
M
T
M
-
V
V
-
V
T
H
E
--------
M
-
G
F
A
R
E
V
A
D
R
V
V
--
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
----------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.35
39%
-110
- C1 -
4YMU
2
?
J:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
MGFAREVG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.02
39%
-114
- C1 -
4YMT
-
?
J:
[3-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
N
D
V
-
Y
K
N
F
G
S
L
E
V
----
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
-------
N
--
G
K
V
N
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
-
A
P
V
---
K
-
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
----
G
L
L
D
K
K
-
D
Q
Y
-
P
I
K
----
L
-----------
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
-
M
K
Q
L
A
N
E
G
-
M
T
M
-
V
V
-
V
T
H
E
MGFAREVG
D
-
R
V
I
-
F
M
D
D
G
V
I
VE
E
G
T
-
P
E
-------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
70.86
39%
-114
- C1 -
1B0U
4
HISP_SALTY
A:
[17-212]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
H
E
V
------
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDG
Q
L
K
V
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
-
M
E
A
P
I
---
Q
-
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
----
G
I
D
E
R
A
-
Q
G
K
Y
P
V
H
----
L
-----------
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
-
M
Q
Q
L
A
E
E
G
-
K
T
M
-
V
V
-
V
T
H
E
------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
57.65
32%
-107
- C1 -
4QC2
2
?
B:
[2-198]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
T
A
K
N
L
A
K
A
Y
-
K
----
G
R
R
V
----
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
S
-------
L
L
P
---
L
H
A
R
A
--
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
-
M
-
A
V
L
---
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
A
N
E
L
M
E
E
F
----
H
I
E
H
L
R
-
D
S
M
-
G
Q
S
----
L
-----------
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
-
I
E
H
L
R
D
S
G
-
L
G
V
-
L
I
-
T
D
H
N
--------
V
-
R
-------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
57.65
34%
-106
- C1 -
1VCI
1
?
A:
[10-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
V
K
L
E
N
L
T
K
R
F
---
G
N
F
T
--
A
----
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
-------
Y
L
P
P
K
D
-------
R
N
-
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
-
A
-
F
P
L
------
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
----
Q
I
E
E
L
L
-
N
R
Y
-
P
A
Q
----
L
-----------
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
-
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
-
K
V
T
-
T
I
Y
V
T
H
D
--------
Q
V
E
A
M
-
T
M
G
D
R
I
----------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
43.84
33%
-78
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[382-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
A
R
P
EVPI
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
-------
Q
L
N
P
V
W
L
------
R
S
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
-
A
-
Y
G
A
---
D
-
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
-
N
T
V
-
V
G
E
KG
V
L
L
-----------
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
-
L
D
R
L
M
D
G
R
-
T
V
L
-
V
I
-
A
H
H
L
--------
S
-
T
I
------------------------------------------------------------------------------------------------------------------------------------------