@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0103c: (2016-04-19 )
MAAPVVGDADLQSVRRIRLDVLGMSCAACASRVETKLNKIPGVRASVNFATRVATIDAVGMAADELCGVVEKAGYHAAPHTETTVLDKRTKDPDGAHARRLLRRLLVAAVLFVPLADLSTLFAIVPSARVPGWGYILTALAAPVVTWAAWPFHSVALRNARHRTTSMETLISVGIVAATAWSLSSVFGDQPPREGSGIWRAILNSDSIYLEVAAGVTVFVLAGRYFEARAKSKAGSALRALAELGAKNVAVLLPDGAELVIPASELKKRQRFVTRPGETIAADGVVVDGSAAIDMSAMTGEAKPVRAYPAASVVGGTVVMDGRLVIEATAVGADTQFAAMVRLVEQAQTQKARAQRLADHIAGVFVPVVFVIAGLAGAAWLVSGAGADRAFSVTLGVLVIACPCALGLATPTAMMVASGRGAQLGIFIKGYRALETIRSIDTVVFDKTGTLTVGQLAVSTVTMAGSGTSERDREEVLGLAAAVESASEHAMAAAIVAASPDPGPVNGFVAVAGCGVSGEVGGHHVEVGKPSWITRTTPCHDAALVSARLDGESRGETVVFVSVDGVVRAALTIADTLKDSAAAAVAALRSRGLRTILLTGDNRAAADAVAAQVGIDSAVADMLPEGKVDVIQRLREEGHTVAMVGDGINDGPALVGADLGLAIGRGTDVALGAADIILVRDDLNTVPQALDLARATMRTIRMNMIWAFGYNVAAIPIAAAGLLNPLIAGAAMAFSSFFVVSNSLRLRNFGAQ
Atome Classification :
(31 SA)
.........10........20........30........40-...-.....50...--..--...60........70........80........90-........100.......---110.......120--.-........130.......140.......-150.......160.-..-....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290........300.......310--------..----------.......320.......330.......340.......350.......360.......370.....-..380.-..-.--....390..--.....400.......410.......420.......430.......440.......450.......-460........470-------------...---------------......480.--------------------.-.----------------....490....-----------------------------...500.-----------.----...----..510.......520-----.--.....---..530...--..-.---------.--540--........550........560.------------------------......570----------------------.........580.......590.......600.......610...-----------------------------------------.------------------------------.-----------------------------------------------------..620.------------......630.......640.......650.......660..-.....670.......680.......690.......700.......710.......-------720------...--..--------...730.......740.......750------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAAPVVG
D
A
D
L
Q
S
V
R
R
I
R
L
D
V
LG
M
S
C
A
A
C
A
S
R
V
E
T
K
L
N
KIP-GV
R
-
A
S
V
N
F
A
T
R
V
A
--
T
I
--
D
A
V
G
M
A
A
D
E
L
C
G
V
V
E
KAGYHAAPHTE
T
T
V
LDKRTK-DP
D
G
A
H
A
R
R
L
L
R
R
L
L
V
A
A
---
V
L
F
V
P
L
A
D
L
S
T
----
L
-
F
A
IVPSARVP
G
W
G
Y
I
L
T
A
L
A
A
P
V
V
T
WAA-WP
F
H
S
V
A
L
R
NARHR-T
T
-
S
M
E
T
L
I
S
V
G
I
V
A
A
T
A
W
S
L
S
S
V
FGDQPPREGS
G
I
W
R
A
I
LNSD
S
I
Y
L
E
VAA
G
V
T
V
F
V
LAGR
Y
F
E
A
R
AKSK
A
G
S
A
L
R
A
L
A
E
LGAK
N
V
A
V
LLPDG
A
E
L
V
I
P
A
S
E
L
K
K
R
Q
R
F
VTRPG
E
T
IAAD
G
V
V
VDGS-
A
A
I
D
M
S
AMTGEAKPVRAYPA----------AS----------VVG
G
T
V
V
MD
G
R
L
V
I
E
A
TAVGA
D
T
Q
F
A
A
M
V
R
L
V
E
Q
A
Q
T
Q
K
A
R
A
Q
R
L
A
D
H
I
A
G
V
F
V
P
V
V
F
V
I
A
G
LAG-
A
A
W
-
L
V-SG-A--GAD
R
A
F
S
V
T
--
L
G
V
L
V
I
ACPCALGLATP
T
A
M
M
V
ASGRG
A
Q
L
G
I
F
I
K
G
Y
R
A
L
E
T
I
R
SI
D
T
V
V
FDKTG
T
L
T
V
G
Q
L
A
V
S
-
T
-
V
T
MAGSGTS
E
---------------
R
D
R
---------------
E
E
V
L
G
L
A
A
A
V
--------------------
E
-
S
----------------
A
S
E
H
A
M
A
A
A
I
V
-----------------------------AASPDPG-----------P----VN
G
----
F
V
A
V
AGCGVSGEVG------G--
H
H
V
EV---GKPS
W
I
T
R--TT-P---------C--H
D
---
A
A
L
V
S
A
RLDG-ESRG
E
T
V
V
F
V
SV------------------------D
G
V
V
R
A
A
------------------------
L
T
I
A
D
T
L
K
D
S
A
A
A
A
V
A
A
L
R
SRG
L
R
T
I
L
L
TGDNR
A
A
A
D
A
V
A
A
QVG
I
-----------------------------------------
D
------------------------------
S
-----------------------------------------------------
A
V
A
D
ML------------PEG
K
V
D
V
I
Q
R
L
R
EEG
H
T
V
A
M
VGDGINDGPA
L
V
GADLGLAIG-RGT
D
V
A
LG
A
A
D
I
I
L
V
RDD
L
N
T
V
P
Q
A
L
D
L
A
R
A
T
M
R
T
I
R
M
N
M
I
W
AFGYNV
A
A
I
P
I
A
A
-------
A
G
-------
L
L
N
--
P
L
--------
I
A
G
A
A
M
A
F
S
S
F
F
V
VSN
S
L
R
LRNFGAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
89.15
38%
-97
- C2 -
3J09
-
COPA_ARCFU
A:
[15-730]
-------------
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
-
V
R
V
N
L
A
T
E
T
A
F
I
R
F
--
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
--------
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
---
F
A
G
V
L
L
L
F
L
A
H
----
F
-
I
S
------
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
-------------
L
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
-
I
Y
W
-
Y
F
-
I
A
H
A
--
P
L
L
F
A
F
T
T
L
--
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
-
L
V
P
L
N
G
--------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
I
E
L
G
-------
E
----
P
E
K
----
V
E
V
I
A
G
E
G
V
V
A
------------
D
G
I
L
V
---
G
N
K
R
L
M
E
D
--
F
G
V
A
---------
V
--
S
N
----
E
V
E
L
A
L
E
K
L
-
E
R
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
-------
G
L
L
Y
P
IFGV
V
F
R
--
P
E
--------
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.81
37%
-97
- C2 -
3J09
-
COPA_ARCFU
A:
[22-728]
--------------------
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
-
G
V
E
E
V
R
V
N
L
A
T
E
T
A
--
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
--------
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
S
----
L
----------
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
-
V
L
P
R
E
Y
S
------------
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
-
A
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
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D
A
M
G
S
K
P
P
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Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
-
I
Y
W
Y
F
I
-
A
H
-
A
--
P
L
L
F
A
F
T
T
L
--
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
EPEK
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
-
A
A
-------
A
G
-------
L
L
Y
--
P
I
FGVVFR
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
87.65
38%
-110
- C2 -
3RFU
3
?
A:
[74-736]
----------------------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
R
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
----
G
G
H
G
L
K
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
---
W
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
QP
A
L
S
Y
G
L
I
A
A
--
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
T
D
D
F
V
--------------------
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
L
S
L
G
-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
A
R
L
M
Q
E
--
H
G
-
G
------------
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPLT
G
L
-------
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
86.15
37%
-111
- C2 -
3RFU
3
?
D:
[83-732]
-------------------------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
H
F
I
S
G
N
---
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
--
Q
P
A
L
S
Y
G
L
I
AA
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
-----
T
D
D
---------------
F
V
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
LSLG-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
-
A
R
L
M
Q
--
E
H
-
G
---------
G
--
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.02
37%
-111
- C2 -
3RFU
3
?
A:
[83-732]
-------------------------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
G
GHG
L
-
K
H
F
I
S
G
N
---
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
--
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
-----
T
D
D
---------------
F
V
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
L
S
L
G
-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
-
A
R
L
M
Q
--
E
H
-
G
---------
G
--
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.84
37%
-111
- C2 -
3RFU
3
?
B:
[83-732]
-------------------------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
H
F
I
S
G
N
---
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
--
Q
P
A
L
S
Y
G
L
I
AA
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
-----
T
D
D
---------------
F
V
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
LSLG-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
-
A
R
L
M
Q
--
E
H
-
G
---------
G
--
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.75
37%
-111
- C2 -
3RFU
3
?
C:
[83-732]
-------------------------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
H
F
I
S
G
N
---
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
--
Q
P
A
L
S
Y
G
L
I
AA
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
-----
T
D
D
---------------
F
V
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
LSLG-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
-
A
R
L
M
Q
--
E
H
-
G
---------
G
--
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.65
37%
-112
- C2 -
4BYG
4
?
A:
[83-732]
-------------------------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
H
F
I
S
G
N
---
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
--
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
-----
T
D
D
---------------
F
V
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
L
S
L
G
-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
-
A
R
L
M
Q
--
E
H
-
G
---------
G
--
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.47
37%
-111
- C2 -
4BEV
2
?
A:
[83-732]
-------------------------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
---
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
H
F
I
S
G
N
---
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
-
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
---
P
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
-
I
V
W
-
A
L
-
L
G
-
P
--
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
-
R
-
I
V
-----
T
D
D
---------------
F
V
E
---------------
D
N
A
L
A
L
A
A
A
L
--------------------
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
I
V
-----------------------------
H
A
A
K
E
K
G
L
S
L
G
-------
S
----
V
E
A
----
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
---
G
N
-
A
R
L
M
Q
--
E
H
-
G
---------
G
--
D
N
---
A
P
L
F
E
K
A
D
E
L
-
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
V
A
L
------------------------
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
-------
G
V
LYPLTGL
L
L
S
--
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
80.33
39%
-99
- C2 -
3J08
-
COPA_ARCFU
A:
[95-730]
--------------------------------------------------------------------------------------------------------
L
S
R
M
K
R
K
L
Y
V
A
A
---
F
A
G
V
L
L
L
F
L
A
H
----
F
-
I
S
------
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
-------------
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
-
I
Y
W
-
Y
F
-
I
A
H
A
--
P
L
L
F
A
F
T
T
L
--
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
-
L
V
P
L
N
G
--------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
I
E
L
G
-------
E
----
P
E
K
----
V
E
V
I
A
G
E
G
V
V
A
------------
D
G
I
L
V
---
G
N
K
R
L
M
E
D
--
F
G
V
A
---------
V
--
S
N
----
E
V
E
L
A
L
E
K
L
-
E
R
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
-------
G
L
L
Y
P
IFGV
V
F
R
--
P
E
--------
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Fugue
80.23
32%
-102
- C2 -
4UMW
2
?
A:
[124-730]
----------------------------------------------------------------------------------------------
R
L
K
-
E
N
----------------------
L
P
L
I
T
L
I
V
----
M
-
M
A
I
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
-
T
T
L
V
G
L
-
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
-
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
--------------------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
-
S
A
L
M
A
L
K
----
P
E
T
A
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
-
L
L
-
F
A
-
A
--
S
W
Q
E
W
I
Y
K
G
--
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
-
A
-
I
H
P
A
----
T
G
---------------
I
S
E
---------------
S
E
L
L
T
L
A
A
A
V
--------------------
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
I
V
-----------------------------
R
E
A
Q
V
A
E
-----------
L
AIPT
A
E
S
----
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
---
C
A
A
G
------
K
H
-
P
-------------
A
---
D
A
F
A
G
L
I
N
E
L
-
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
L
G
I
------------------------
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
--
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.05
38%
-98
- C2 -
3J08
-
COPA_ARCFU
A:
[94-728]
-------------------------------------------------------------------------------------------------------
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
S
----
L
----------
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
-
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
P
-
R
E
Y
S
------------
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
-
A
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
-
I
Y
W
Y
F
I
-
A
H
-
A
--
P
L
L
F
A
F
T
T
L
--
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
-
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
EP
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
-
A
A
-------
A
G
-------
L
L
Y
--
P
I
FGVVFR
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
78.23
31%
-107
- C2 -
4UMW
2
?
A:
[124-730]
----------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
---
L
--
I
V
M
M
A
I
S
W
----
G
-
L
E
Q
----
F
N
H
P
F
G
Q
L
A
---
F
I
A
T
T
L
V
G
L
-
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
-
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
--------------------------
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
-
L
V
P
-
P
L
L
F
A
-
A
--
S
W
Q
E
W
I
Y
K
G
--
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
-
A
-
I
H
P
A
T
G
-------------------
I
S
E
---------------
S
E
L
L
T
L
A
A
A
V
--------------------
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
I
V
-----------------------------
R
E
A
Q
V
A
E
LAIP-------
T
----
A
E
S
----
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
---
C
A
A
G
K
H
P
A
--
D
---------------------
A
F
A
G
L
I
N
E
L
-
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
L
G
I
------------------------
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------
E
------------------------------------------------------------------------------------
F
K
A
G
L
L
------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
--
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.88
30%
-105
- C2 -
4UMW
2
?
A:
[124-728]
----------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
-----------
P
L
I
T
L
I
V
----
M
-
M
A
I
--
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
-
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
--------------------------
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
-
A
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
-
L
V
P
-
P
L
-
L
F
-
A
--
A
S
W
Q
E
W
I
Y
K
G
-
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
-
A
-
I
H
P
A
-
T
G
I
S
E
---------------------------------
S
E
L
L
T
L
A
A
A
V
--------------------
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
-------------------------
V
A
E
L
A
I
P
-----------
T
----
A
E
S
----
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
C
A
A
G
K
------------------------
H
P
---
A
D
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
L
G
I
------------------------
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------
E
------------------------------
F
-----------------------------------------------------
K
-
A
G
L
L
------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
--
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.66
30%
-97
- C2 -
4UMV
2
?
A:
[126-728]
------------------------------------------------------------------------------------------------------------
K
E
N
L
-----------
P
L
I
T
L
I
V
----
M
-
M
A
I
--
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
-
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
--------------------------
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
-
A
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
-
L
V
P
-
P
L
-
L
F
-
A
--
A
S
W
Q
E
W
I
Y
K
G
-
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
-
A
-
I
H
P
A
-
T
G
I
S
E
---------------------------------
S
E
L
L
T
L
A
A
A
V
--------------------
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
-------------------------
V
A
E
L
A
I
P
-----------
T
----
A
E
S
----
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
C
A
A
G
K
------------------------
H
P
---
A
D
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
L
G
I
------------------------
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------
E
------------------------------
F
-----------------------------------------------------
K
-
A
G
L
L
------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
-------
L
G
-------
M
T
G
--
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
67.64
22%
-86
- C2 -
2ZXE
5
?
A:
[138-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
-
D
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
-
I
L
S
-
L
I
-
L
G
-
Y
--
S
W
L
E
A
V
I
F
L
--
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
-
H
-
M
W
F
D
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
---------------
S
A
L
S
R
I
A
A
L
C
--------------------
N
-
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
D
A
S
E
S
A
L
L
-----------------------------
K
C
I
E
L
C
C
GS
V
Q
G
M
R
D
R
N
P
K
I
V
--
E
I
P
----
F
N
S
T
-
N
K
Y
Q
L
S
I
H
E
NEKSSE
S
R
Y
L
L
V
M
K
---
G
A
P
E
R
I
L
D
--
R
C
S
T
ILLNG
A
E
E
P
L
--
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
-
G
G
L
G
E
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
L
C
F
V
G
L
------------------------
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
-----------------------------------------
I
------------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
------------
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
65.69
19%
-81
- C2 -
3B8E
6
AT1A1_PIG
A:
[1-998]
-------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
------------------------------
T
D
L
S
R
G
L
T
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
T
-
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
---
L
W
I
G
A
I
L
--------------------------------------------------------------------
C
F
L
A
Y
G
I
Q
A
A
T
E
E
E
P
Q
N
D
N
--------------
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
-
A
L
V
I
R
N
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
-
I
L
S
-
L
I
-
L
E
-
Y
--
T
W
L
E
A
V
I
F
L
--
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
-
H
-
M
W
S
D
N
Q
I
H
E
A
---------------
D
T
T
ENQSGVSFDKTS
A
T
W
L
A
L
S
R
I
A
G
L
C
NR
A
V
F
Q
A
NQENLPILK
R
A
V
A
G
-
D
----------------
A
S
E
S
A
L
L
K
C
I
E
L
CCGS
V
K
E
M
R
E
R
Y
TKIVEIPFNSTN
K
Y
Q
L
S
I
H
K
N
P
N
-----------
T
----
A
E
P
----
R
H
L
L
V
M
K
G
A
P
E
R
I
L
------
D
--
R
C
S
S
I
---
L
I
H
G
K
E
Q
P
--
L
D
-
E
---------
E
--
L
K
---
D
A
F
Q
N
A
Y
L
E
L
-
G
G
L
G
E
R
V
L
G
F
C
H
------------------------
L
F
L
P
D
E
Q
FPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
------------------------------
E
-----------------------------------------------------
Q
L
D
D
I
L
K
YHTEIVFARTS
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
-------
I
F
-------
I
I
A
NI
P
L
--------
P
L
G
T
V
T
I
L
C
-
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
QAESDIMKRQPRNPKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
63
HHSearch
58.52
26%
-80
- C2 -
3B8C
2
PMA2_ARATH
A:
[114-658]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
N
A
G
N
A
A
A
A
L
M
A
G
L
A
P
K
T
K
V
L
R
-
D
G
K
W
S
E
Q
E
A
A
I
L
V
P
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
G
D
P
L
K
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
K
H
P
G
----------
Q
E
----------
V
F
S
G
S
T
C
K
Q
G
E
I
E
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
S
T
N
-
Q
V
G
H
F
Q
K
V
L
T
A
I
G
N
F
C
I
C
S
I
A
I
G
M
V
I
E
I
-
I
V
M
-
Y
P
I
Q
R
-
R
--
K
Y
R
D
G
I
D
N
L
--
L
V
L
L
I
G
G
I
P
I
A
M
P
T
V
L
S
V
T
M
A
I
G
S
H
R
L
S
Q
Q
G
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
K
L
S
V
D
-
K
-
N
L
V
E
V
F
-
C
K
G
---------------
V
E
K
---------------
D
Q
V
L
L
F
A
A
M
A
--------------------
S
R
V
----------------
E
N
Q
D
A
I
D
A
A
M
V
-----------------------------
G
M
L
A
D
P
K
EARAGIREV--
H
----
F
L
P
----
F
N
P
V
D
-
K
R
T
A
L
T
Y
I
DGS---
G
N
W
H
R
V
S
K
---
G
A
P
E
Q
I
L
E
--
L
A
K
A
---------
S
ND
L
S
---
K
K
V
L
S
I
I
D
K
Y
-
A
E
R
G
L
R
S
L
A
V
A
R
Q
VVPEKTKESPG
A
-----------
P
W
E
F
V
G
L
------------------------
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
N
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
M
-----------------------------------------
G
TNMYPSSALLGTHKDANLASIP
V
E
E
L
I
E
K
A
D
-----------------------------------------------------
G
F
A
G
V
F
------------
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
I
F
Q
R
M
K
N
Y
T
I
Y
A
V
S
I
T
I
R
I
V
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.39
37%
-90
- C2 -
3SKY
2
A:
[5-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
-
D
-
I
V
--
G
F
N
H
S
E
---------------------------------
D
E
L
L
Q
I
A
A
S
L
--------------------
E
-
A
----------------
R
S
E
H
P
I
A
A
A
I
V
-----------------------------
E
E
A
E
K
R
G
F
G
L
T
-------
E
----
V
E
E
----
F
R
A
I
P
G
K
G
V
E
G
I
V
N
------
G
--
R
R
Y
M
V
---
V
S
P
G
Y
I
R
E
--
L
G
-
I
---------
K
--
T
D
---
E
S
V
E
K
L
K
-----
Q
Q
G
K
T
V
V
F
I
L
K
------------------------
N
G
E
V
S
G
V
------------------------
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
------------
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
-
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.97
36%
-93
- C2 -
3SKX
2
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
-
D
-
I
V
--
G
F
N
H
S
E
---------------------------------
D
E
L
L
Q
I
A
A
S
L
--------------------
E
-
A
----------------
R
S
E
H
P
I
A
A
A
I
V
-----------------------------
E
E
A
E
K
R
G
F
G
L
T
-------
E
----
V
E
E
----
F
R
A
I
P
G
K
G
V
E
G
I
V
N
------
G
--
R
R
Y
M
V
---
V
S
P
G
Y
I
R
E
--
L
G
-
I
---------
K
--
T
D
---
E
S
V
E
K
L
K
-----
Q
Q
G
K
T
V
V
F
I
L
K
------------------------
N
G
E
V
S
G
V
------------------------
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
------------
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
-
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
57.54
39%
-85
- C2 -
3A1C
2
?
A:
[14-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
-
L
V
P
L
N
G
--------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
I
E
L
G
-------
E
----
P
E
K
----
V
E
V
I
A
G
E
G
V
V
A
------------
D
G
I
L
V
---
G
N
K
R
L
M
E
D
--
F
G
V
A
---------
V
--
S
N
----
E
V
E
L
A
L
E
K
L
-
E
R
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
57.31
38%
-89
- C2 -
3A1D
2
?
B:
[13-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
L
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
EP
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.92
38%
-88
- C2 -
3A1E
2
COPA_ARCFU
A:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
L
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
Q
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.81
38%
-88
- C2 -
3A1D
2
?
A:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
L
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.79
38%
-86
- C2 -
3A1C
2
?
A:
[14-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
L
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
56.47
38%
-89
- C2 -
3A1C
1
?
B:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
L
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
H
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
EPEK
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
FG
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.02
38%
-88
- C2 -
3A1E
1
B:
[13-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
-
D
L
V
P
L
N
G
---------------------
D
E
---------------
R
E
L
L
R
L
A
A
I
A
--------------------
E
-
R
----------------
R
S
E
Q
P
I
A
E
A
I
V
-----------------------------
K
K
A
L
E
H
G
-----------
I
----
E
L
G
EP
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
---
G
N
K
R
L
M
E
D
F
G
V
A
-
V
---------
S
--
N
E
---
V
E
L
A
L
E
K
L
E
R
-
E
A
K
--
T
A
V
I
V
A
R
------------------------
N
G
R
V
E
G
I
------------------------
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
49.90
31%
-80
- C2 -
2YJ4
1
?
B:
[13-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
-
Q
---
F
I
G
D
S
L
S
-------------------------------------
L
A
Y
A
A
S
V
--------------------
E
-
A
----------------
L
S
S
H
P
I
A
K
A
I
V
-----------------------------
K
Y
A
K
E
Q
G
V
K
I
L
-------
E
----
V
K
D
----
F
K
E
I
S
G
I
G
V
R
G
K
I
S
------
D
--
K
I
I
E
V
---
K
K
--------------------------------------
A
-
E
N
N
N
D
I
A
V
Y
I
N
G
------------------------
E
P
I
--
A
S
------------------------
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
49.15
31%
-85
- C2 -
2YJ3
4
?
A:
[13-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
E
K
T
G
T
L
T
Y
G
T
P
I
V
T
-
Q
---
F
I
G
D
S
L
S
-------------------------------------
L
A
Y
A
A
S
V
--------------------
E
-
A
----------------
L
S
S
H
P
I
A
K
A
I
V
-----------------------------
K
Y
A
K
E
Q
G
V
K
I
L
-------
E
----
V
K
D
----
F
K
E
I
S
G
I
G
V
R
G
K
I
S
------
D
--
K
I
I
E
V
---
K
K
-------------------------------------------
N
D
I
A
V
Y
I
N
G
------------------------
E
P
I
--
A
S
------------------------
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
--
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
--------
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
48.97
31%
-83
- C2 -
2YJ6
1
?
A:
[13-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
-
Q
---
F
I
G
D
S
L
S
-------------------------------------
L
A
Y
A
A
S
V
--------------------
E
-
A
----------------
L
S
S
H
P
I
A
K
A
I
V
-----------------------------
K
Y
A
K
E
Q
G
V
K
I
L
-------
E
----
V
K
D
----
F
K
E
I
S
G
I
G
V
R
G
K
I
S
------
D
--
K
I
I
E
V
---
K
K
--------------------------------------
A
-
E
N
N
N
D
I
A
V
Y
I
N
G
------------------------
E
P
I
--
A
S
------------------------
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
---
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
48.37
31%
-80
- C2 -
2YJ5
1
?
B:
[13-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
-
Q
---
F
I
G
D
S
L
S
-------------------------------------
L
A
Y
A
A
S
V
--------------------
E
-
A
----------------
L
S
S
H
P
I
A
K
A
I
V
-----------------------------
K
Y
A
K
E
Q
G
V
K
I
L
-------
E
----
V
K
D
----
F
K
E
I
S
G
I
G
V
R
G
K
I
S
------
D
--
K
I
I
E
V
---
K
K
--------------------------------------
A
-
E
N
N
N
D
I
A
V
Y
I
N
G
------------------------
E
P
I
--
A
S
------------------------
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------
Q
------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------