@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0111: (2016-04-19 )
MPARSVPRPRWVAPVRRVGRLAVWDRPERRSGIPALDGLRAIAVALVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFWIRRARRLLPALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFVAQNTDYFTQGAPPSPLQHTWSLGVEEQYYVVWPLLLIGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMASATAAVAFTSAATRDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARLLPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARILAWRPLVWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLIEQPIRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAVAAVSPSPPEASQPAPGPRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFRFIDHTVIGCSLVRGTPYRYIGQTLEQRAECDGWPARWSAQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDPTFDAYLNAELQRALSIVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQHSNVGMIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVRVAS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..-.....480-...--.---------...--------.--490---.----....-....500.....-..510.......520---........530.-..-.-.-...540.......550.....-..-560-----------......-.570.-......580...--.--...590...-.....-600.-...-...610.......620.......630.......640-....-...650.......660.......670-.......680...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPARSVPRPR
W
V
A
P
V
R
RVGRLAVWDR
P
E
RRSGIP
A
L
D
G
L
R
A
I
A
V
A
L
V
L
A
SHGGIPGMGG
G
F
I
G
V
D
A
F
F
V
L
S
G
F
L
I
T
S
L
L
L
D
ELGRT
G
R
I
DL
S
G
F
W
I
R
R
A
R
R
L
L
P
A
L
V
L
M
V
L
T
V
S
A
A
R
ALF
P
D
Q
A
L
T
G
L
R
S
D
A
I
A
A
F
L
WTA
N
W
R
F
V
AQNTDYFTQGAPPSP
L
Q
H
T
WSLGVE
E
Q
Y
Y
V
V
W
P
L
L
L
I
G
A
T
L
L
L
A
A
R
A
R
R
R
C
R
RATVG
G
V
R
F
A
A
F
L
I
A
S
L
G
T
M
A
S
A
T
A
A
V
A
F
TSAATR
D
R
I
Y
FGTDTR
A
Q
A
L
L
I
G
S
A
A
A
A
L
L
V
RDWPSLNR
G
W
C
L
I
R
T
R
W
G
R
R
I
A
R
L
L
P
F
V
GLAG
L
A
V
T
T
H
VATGS
V
G
E
FRH
G
L
L
I
V
VAGA
A
V
I
V
V
A
S
V
A
M
E
QR
G
A
V
A
R
I
LAWR
P
L
V
W
L
G
TISY
G
V
Y
L
W
H
W
P
I
F
L
A
LNGQRTGWS
G
P
A
L
F
A
A
R
C
A
A
T
V
V
L
AGAS
W
W
L
I
E
Q
P
I
R
RWRPARV
P
L
L
P
L
A
A
A
T
V
A
SA
A
A
V
T
M
L
V
V
PVGAGPGLREIGLPPGV
S
A
VAAVSPSPPEASQPAPGPRDPNR
P
F
T
V
S
VF-GDSI
G
W
T
--
L
M
H--Y---------LPP--------T--P-----G----
F
R
F
I
-DH
T
V
IGCSLVRG-T
P
Y
R
Y
I
G
Q
T
L
E
Q
R
A----ECDGWPARW-SA-QV-N-R-DQP
D
V
A
L
L
I
V
GRW
E
T
V
D
RVNE-G
R
-
W
T
H-----------IGD
P
T
F
-
D
A
Y
L
N
-
A
E
L
Q
R
A
L
S
I
VGS--T--G
V
R
V
M
-
V
T
T-VPYSR-GGEK-PDG-RLYPEDQ
P
E
R
V
N
K
W
N
A
M
L
H
N
A
I
S
QHSNV
G
M
I
DLNKK-LCPD-G
V
Y
T
A
KVD
G
I
K
VRSDGV
H
L
T
Q
E
G
V
K
W
-
L
I
P
W
L
EDSVRVAS--
16
HHSearch
87.92
15%
-66
* C1 *
4IYJ
3
?
A:
[28-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
D
R
V
V
F
M
-
G
N
S
I
T
E
G
--
W
V
A
--
N
---------
D
A
A
--------
F
F
-
E
-----
D
----
N
G
Y
V
-
G
R
G
I
G
G
--------------------
Q
----
T
S
S
H
F
L
L
R
F
-
R
E
-
D
V
-
I
-
K
-
L
A
P
A
L
V
V
I
N
A
G
T
N
D
I
A
E
N
A
G
----------------------
A
Y
N
-
E
E
Y
T
F
-
G
N
I
V
S
M
V
E
L
A
R
A
--
N
--
K
I
K
V
I
-
L
T
S
-
V
L
P
A
A
A
F
G
W
N
-
P
S
V
-----
K
D
A
P
Q
K
I
M
Q
L
N
A
R
I
R
K
Y
A
Q
E
N
-
K
I
P
Y
V
D
Y
Y
S
E
-
M
V
E
G
-
D
N
K
---
A
L
N
S
S
Y
T
R
D
G
V
H
P
T
L
E
G
Y
K
V
-
M
E
A
L
I
K
K
A
I
D
K
V
---
12
HHSearch
87.17
16%
-75
- C1 -
2HSJ
4
?
A:
[33-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
P
N
I
L
F
I
-
G
D
S
I
V
E
Y
--
Y
P
-------------
L
Q
E
--------
L
FG
T
-----
S
----
K
T
I
V
-
N
R
G
I
R
G
Y
Q
T
G
L
------------------------
L
L
E
N
L
-
D
A
-
H
L
-
Y
-
G
-
G
A
V
D
K
I
F
L
L
I
G
T
N
D
I
G
K
D
-------------------------
V
P
-
V
N
E
A
L
-
N
N
L
E
A
I
I
Q
S
V
A
R
--
D
Y
P
L
T
E
I
K
-
L
L
S
-
I
L
P
V
N
-
E
R
E
E
-
Y
Q
Q
-
A
V
Y
-
I
R
S
N
E
K
I
Q
N
W
N
Q
A
Y
Q
E
L
A
S
A
Y
M
Q
V
E
F
V
P
V
F
D
C
-
L
T
D
Q
-
A
G
Q
L
----
K
K
E
Y
T
T
D
G
L
H
L
S
I
A
G
Y
Q
A
-
L
S
K
S
L
K
D
Y
L
Y
-----
25
HHSearch
86.65
14%
-71
- C1 -
1FXW
-
PA1B2_BOVIN
F:
[38-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
P
D
V
L
F
V
-
G
D
S
M
V
Q
L
--
M
Q
Q
--
Y
EI-------
W
R
E
--------
L
F-
S
-----
P
----
L
H
A
L
-
N
F
G
I
G
G
D
------------------------
T
T
R
H
V
L
W
R
L
-
K
N
G
E
L
-
E
-
N
-
I
K
P
K
V
I
V
V
W
V
G
T
N
N
H
E
N
T
----------------------------
A
E
E
V
A
-
G
G
I
E
A
I
V
Q
L
I
N
T
--
R
QP
Q
A
K
I
I
-
V
L
G
-
L
L
P
R
G
-
E
K
---
P
N
-------
P
L
R
Q
K
N
A
K
V
N
Q
L
L
K
V
S
L
P
K
L
A
N
V
Q
L
L
D
T
D
G
G
-
F
V
H
S
-
D
G
A
----
I
S
C
H
D
M
F
D
F
L
H
L
T
G
G
G
Y
A
K
-
I
C
K
P
L
H
E
L
I
M
Q
L
---
21
HHSearch
84.88
15%
-70
- C1 -
4H08
3
?
A:
[19-197]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
H
V
L
L
I
-
G
N
S
I
T
R
G
--
Y
Y
G
--
K
---------
V
E
A
--------
A
L
-
K
-----
E
KAYV
G
R
L
S
-
N
S
K
S
V
G
D
-------------------------
P
-
A
L
I
E
E
L
-
A
V
-
V
L
-
K
-
N
-
T
K
F
D
V
I
H
F
N
N
G
L
H
G
F
D
Y
T
----------------------------
E
E
E
Y
D
-
K
S
F
P
K
L
I
K
I
I
R
K
--
Y
AP
K
A
K
L
I
-
W
A
N
-
T
T
P
V
R
-
T
G
E
G
-
M
K
E
-
F
---
A
P
I
T
E
R
L
N
V
R
N
Q
I
A
L
K
H
I
-
N
R
A
S
I
E
V
N
D
L
W
K
V
-
V
I
D
H
-
P
E
-------
Y
Y
A
G
G
D
G
T
H
P
I
D
A
G
Y
S
A
-
L
A
N
Q
V
I
K
V
I
K
N
V
---
37
Fugue
84.50
14%
-43
- C1 -
1FXW
-
PA1B2_BOVIN
F:
[6-217]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
P
A
A
I
P
H
A
A
E
D
I
Q
G
D
D
R
W
-
M
S
Q
H
N
R
F
--
V
L
D
--
C
---------
K
D
K
--------
E
--
P
-----
D
----
V
L
F
V
G
D
S
M
V
Q
L
M
Q
Q
Y
E
I
-
W
R
E
L
F
S
P
L
H
A
L
N
F
G
IGGD
T
T
R
H
V
L
W
R
L
-
K
N
-
G
E
L
E
-
N
-
I
K
P
K
V
I
V
V
W
V
G
----------------------------
T
N
N
H
E
N
T
A
E
E
V
A
-
G
G
I
E
A
I
V
Q
L
I
N
T
--
R
--
Q
P
Q
A
K
-
I
I
V
-
L
G
L
L
P
-
R
G
E
K
-
P
N
-------
P
L
R
Q
K
N
A
K
V
N
Q
L
L
K
V
S
L
P
K
L
A
N
V
Q
L
L
D
T
D
G
G
-
F
V
H
S
-
D
G
A
I
S
C
----
H
D
M
F
D
F
L
H
L
T
G
G
G
Y
A
K
-
I
C
K
P
L
H
E
L
I
M
Q
L
L
--
32
Fugue
83.76
14%
-55
- C1 -
4H08
3
?
A:
[1-200]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
E
Y
I
E
W
S
D
I
W
I
P
G
A
N
K
T
D
L
P
H
V
L
L
I
-
G
N
S
I
T
R
G
--
Y
Y
G
--
K
---------
V
E
A
--------
A
---------------
L
K
-
E
K
A
Y
V
G
R
L
S
N
S
K
-------
S
V
G
D
----------
P
A
L
I
E
E
L
-
A
V
-
V
L
-
K
-
N
-
T
K
F
D
V
I
H
F
N
N
G
L
H
---------------------------
G
F
D
Y
T
-
E
E
E
Y
D
-
K
S
F
P
K
L
I
K
I
I
R
K
Y
A
P
--
K
A
K
L
I
-
W
A
N
-
T
T
P
V
R
-
T
G
E
G
M
K
E
F
-----
A
P
I
T
E
R
L
N
V
R
N
Q
I
A
L
K
H
I
N
R
A
-
S
I
E
V
N
D
L
W
K
V
-
V
I
D
H
--------
P
E
Y
Y
A
G
G
D
G
T
H
P
I
D
A
G
Y
S
A
-
L
A
N
Q
V
I
K
V
I
K
N
V
L
VH
11
HHSearch
79.97
15%
-74
- C1 -
3P94
1
?
A:
[21-202]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
S
N
V
V
F
M
-
G
N
S
I
T
D
G
--
W
W
P
--
A
---------
D
S
T
--------
F
F
-
I
-----
R
----
N
N
F
V
-
D
R
G
I
S
G
--------------------
Q
----
T
T
S
E
M
L
V
R
F
-
R
Q
-
D
V
-
I
-
N
-
L
K
P
K
A
V
V
I
L
A
G
I
N
D
I
A
H
N
N
G
---------------------
V
I
A
--
L
E
N
V
F
-
G
N
L
V
S
M
A
E
L
A
K
A
--
N
--
H
I
K
V
I
-
F
C
S
-
V
L
P
A
Y
-
D
F
P
W
-
R
P
G
-
M
----
Q
P
A
D
K
V
I
Q
L
N
K
W
I
K
E
Y
A
-
D
K
N
G
L
T
Y
V
D
Y
H
S
A
-
M
K
D
E
-
R
N
G
L
----
P
A
N
L
S
K
D
G
V
H
P
T
L
E
G
Y
K
I
-
M
E
K
I
V
L
E
A
I
H
K
T
---
22
HHSearch
79.02
14%
-83
- C1 -
1ES9
-
PA1B3_BOVIN
A:
[37-215]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
P
E
V
V
F
I
-
G
D
S
L
V
Q
L
--
M
H
Q
CE
I
---------
W
R
E
--------
L
F-
S
-----
P
----
L
H
A
L
-
N
F
G
I
G
G
D
S
T
Q
------------------------
H
V
L
W
R
L
-
E
N
-
G
E
L
E
-
H
-
I
R
P
K
I
V
V
V
W
V
G
T
N
N
H
G
H
T
----------------------------
A
E
Q
V
T
-
G
G
I
K
A
I
V
Q
L
V
N
E
--
R
QP
Q
A
R
V
V
-
V
L
G
-
L
L
P
R
G
-
Q
H
---
P
N
-------
P
L
R
E
K
N
R
R
V
N
E
L
V
R
A
A
L
A
G
H
P
R
A
H
F
L
D
A
D
P
G
-
F
V
H
S
-
D
G
T
----
I
S
H
H
D
M
Y
D
Y
L
H
L
S
R
L
G
Y
T
P
-
V
C
R
A
L
H
S
L
L
L
R
L
---
23
HHSearch
77.13
16%
-58
- C1 -
4JGG
-
EST_PSEAE
A:
[1-178]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
L
L
V
V
-
G
D
S
I
S
A
A
--
L
G
L
--
D
TSQG
W
V
A
L
-
L
Q
K
--------
R
--
L
A
D
E
G
Y
D
----
Y
R
V
V
-
N
A
S
I
S
G
D
T
S
------------------------
A
G
G
L
A
R
L
-
P
A
-
L
L
-
A
-
E
-
E
K
P
A
L
V
V
I
E
L
G
G
N
D
G
L
R
G
M
-------------------------
A
-
P
A
Q
L
Q
-
Q
N
L
A
S
M
A
Q
K
A
R
A
--
E
--
G
A
K
V
L
-
L
L
G
-
I
Q
L
P
P
-
N
Y
-------------
G
P
R
Y
I
E
A
F
S
R
V
Y
G
A
V
A
-
A
Q
E
K
T
A
L
V
P
F
F
L
E
-
G
V
G
G
--------
V
Q
G
M
M
Q
A
D
G
I
H
P
A
L
A
A
Q
P
R
-
L
L
E
N
V
W
P
T
L
K
P
----
26
HHSearch
76.24
14%
-50
- C1 -
1K7C
6
RHA1_ASPAC
A:
[1-215]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
V
Y
L
A
-
G
D
S
T
M
A
K
--
N
G
G
--
G
SGTNGWGEY
L
A
S
--------
Y
--
L
-----
S
----
A
T
V
V
-
N
D
A
V
A
G
R
S
A
R
S
--------------
Y
T
----
R
E
----
G
R
F
-
E
N
-
I
A
-
D
-
V
V
T
A
G
D
Y
V
I
V
E
F
G
H
N
D
G
G
S
L
S
T
D
N
G
R
T
D
C
S
GTGA
E
V
C
Y
S
V
Y
D
G
V
N
E
T
-
I
L
T
F
P
-
A
Y
L
E
N
A
A
K
L
F
T
A
--
K
--
G
A
K
V
I
-
L
S
S
-
Q
T
P
N
N
-
P
W
-
E
-
T
G
-------
T
F
V
N
S
P
T
R
F
V
E
Y
A
E
L
A
A
-
E
V
A
G
V
E
Y
V
D
H
W
S
Y
-
V
D
S
I
Y
E
T
L
G
N
A
T
V
N
S
Y
F
P
I
D
H
T
H
T
S
P
A
G
A
E
V
-
V
A
E
A
F
L
K
A
V
V
C
T
---
17
HHSearch
74.22
12%
-59
- C1 -
4S1P
1
?
A:
[2-185]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
R
I
L
M
L
-
G
N
S
L
T
T
A
NH
M
P
D
--
M
---------
L
A
E
--------
L
--
L
-----
T
----
A
E
V
R
-
V
H
A
R
G
G
A
R
L
A
E
H
-
L
-----------------
N
P
K
T
R
N
G
A
L
T
Q
A
-
A
L
-
A
-
N
-
E
A
W
D
F
V
V
M
Q
E
M
S
H
G
P
A
T
---------------------------
S
-
P
T
A
Y
A
-
R
S
V
A
S
L
S
E
A
A
K
A
--
A
--
G
A
Q
P
V
-
I
Y
G
T
W
P
Y
R
A
-
G
C
---
A
K
L
-
V
K
L
G
M
S
H
D
D
M
S
L
R
M
A
E
A
F
A
Q
A
A
A
-
D
S
G
A
L
L
A
D
V
A
A
P
-
F
R
A
G
-
S
------
A
D
E
L
Y
A
A
D
G
V
H
P
S
P
A
G
S
R
L
-
A
A
L
V
L
A
E
T
M
G
-----
34
Fugue
72.93
14%
-54
- C1 -
1IVN
2
TESA_ECOLI
A:
[1-179]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
T
L
L
I
L
-
G
D
S
L
S
A
--------------------------------------
G
----
Y
R
M
S
-
A
S
A
A
W
P
A
L
L
N
D
K
-
W
S
K
T
S
V
V
N
A
S
I
S
G
D
----
T
S
Q
Q
G
L
A
R
L
-
P
A
-
L
L
-
K
-
Q
-
H
Q
P
R
W
V
L
V
E
L
G
G
N
D
G
L
R
G
F
Q
--------------------------
P
Q
Q
T
E
-
Q
T
L
R
Q
I
L
Q
D
V
K
A
--
A
--
N
A
E
P
L
-
L
M
Q
-
I
R
L
---------------
P
A
N
Y
G
R
R
Y
N
E
A
F
S
A
I
Y
P
K
L
A
K
E
F
D
V
P
L
L
P
F
F
M
E
-
E
V
Y
L
-
K
P
Q
W
M
Q
D
D
G
I
H
P
N
R
D
A
Q
P
F
I
A
D
W
M
A
K
-
Q
L
Q
P
L
V
N
--------
20
HHSearch
72.43
21%
-30
- C1 -
1YZF
-
?
A:
[63-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
-
I
-
E
K
P
D
E
V
V
I
F
F
G
A
N
D
A
S
L
D
R
----------------------
N
-
I
T
-
V
A
T
F
R
-
E
N
L
E
T
M
I
H
E
I
G
S
------
E
K
V
I
-
L
I
T
-
P
P
Y
A
D
-
S
G
R
R
-
P
-------
E
R
P
Q
T
R
I
K
E
L
V
K
V
A
Q
E
V
G
-
A
A
H
N
L
P
V
I
D
L
Y
K
A
-
M
T
V
Y
-
P
G
T
-----
D
E
F
L
Q
A
D
G
L
H
F
S
Q
V
G
Y
E
L
-
L
G
A
L
I
V
R
E
I
K
G
R
---
38
Fugue
70.69
16%
-39
- C1 -
3P94
1
?
A:
[1-204]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
G
D
W
A
Q
F
G
R
Y
A
E
A
N
K
T
V
K
V
P
S
N
V
V
F
M
G
N
S
I
T
D
G
--
W
W
P
--
A
---------
D
S
T
--------
F
--
F
-----
I
----
R
N
N
F
-
V
D
R
G
I
S
G
Q
T
T
S
E
M
L
V
-----------------------
R
F
-
R
Q
-
D
V
-
I
-
N
-
L
K
P
K
A
V
V
I
L
A
G
----
I
N
D
I
A
H
-
N
N
-
G
V
I
-----------
A
L
E
N
V
F
-
G
N
L
V
S
M
A
E
L
A
K
A
--------
N
--
H
I
K
V
I
-
F
C
S
-
V
L
P
A
Y
-
D
F
P
W
-
R
P
G
M
Q
P
-----
A
D
K
V
I
Q
L
N
K
W
I
K
E
Y
A
D
K
N
-
G
L
T
Y
V
D
Y
H
S
A
M
K
D
E
R
-
N
G
L
P
A
N
L
-----
S
K
D
G
V
H
P
T
L
E
G
Y
K
I
M
E
K
I
V
L
E
A
I
H
K
T
V
K
--
15
HHSearch
68.99
11%
-76
- C1 -
4RSH
-
?
A:
[4-178]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
K
V
V
A
I
-
G
D
S
F
T
F
G
--
Y
P
G
--
N
---------
T
E
N
S
W
P
A
V
L
G
Q
T
--
S
-----
Q
----
I
E
V
V
-
N
K
G
L
K
S
Q
T
------------------------
A
Q
D
L
Y
S
R
F
-
D
A
-
D
V
-
L
-
A
-
E
K
P
G
R
V
I
I
F
V
G
N
G
D
A
I
K
E
-------------------------
V
P
-
L
E
T
F
Q
-
Q
H
I
K
A
M
V
E
K
A
E
S
--
N
--
H
I
I
P
I
-
L
A
L
-
P
L
P
Y
T
-
G
V
--------------
Q
N
T
I
K
E
F
R
E
W
E
S
S
Y
A
-
K
E
K
N
I
L
V
L
D
F
A
T
V
-
L
M
D
A
-
D
N
V
---
Y
L
E
G
L
L
S
K
E
A
N
Y
P
S
K
E
G
Y
K
L
-
M
G
E
Y
A
S
R
V
L
------
30
Fugue
67.74
12%
-41
- C1 -
1FXW
1
PA1B3_BOVIN
A:
[5-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
P
A
S
K
P
T
P
V
Q
D
V
Q
G
D
G
R
W
-
M
S
L
H
H
R
F
--
V
A
D
--
S
---------
K
D
K
--------
E
--
P
-----
E
----
V
V
F
I
G
D
S
L
V
Q
L
M
H
Q
C
E
I
-
W
R
E
L
F
S
P
L
H
A
L
N
F
G
I
G
GD
S
T
Q
H
V
L
W
R
L
-
E
N
-
G
E
L
E
-
H
-
I
R
P
K
I
V
V
V
W
V
G
T
N
N
H
---------------------------
G
H
T
-
A
E
Q
V
T
-
G
G
I
K
A
I
V
Q
L
V
N
E
--
R
--
Q
P
Q
A
R
-
V
V
V
-
L
G
L
L
P
-
R
G
Q
H
-
P
N
-------
P
L
R
E
K
N
R
R
V
N
E
L
V
R
A
A
L
A
G
H
P
R
A
H
F
L
D
A
D
P
G
-
F
V
H
S
-
D
G
T
I
S
H
----
H
D
M
Y
D
Y
L
H
L
S
R
L
G
Y
T
P
-
V
C
R
A
L
H
S
L
L
L
R
L
---
13
HHSearch
65.44
16%
-49
- C1 -
4C1B
-
?
A:
[133-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
M
D
V
A
I
I
-
G
D
S
I
V
R
H
--
V
R
A
--
A
---------
S
S
------------
K
-----
G
----
N
K
V
R
-
T
F
C
F
P
G
A
R
V
K
N
I
------------------------
S
T
Q
I
-
P
T
-
I
L
-
G
A
A
-
E
S
P
G
A
V
V
L
H
V
G
T
N
D
T
G
L
R
--------------------------
Q
-
S
E
I
L
K
-
K
D
F
R
S
L
I
E
T
V
R
R
--
T
SP
A
T
Q
I
I
-
V
S
G
-
P
L
P
T
Y
-
R
R
---
G
N
-------
E
R
F
S
R
L
L
A
L
N
E
W
L
I
T
W
C
K
E
-
Q
K
L
L
F
A
N
N
W
N
L
-
F
W
E
R
-
P
--------
R
L
F
R
P
D
G
L
H
P
S
R
A
G
A
E
L
-
L
S
D
N
I
S
R
L
L
R
T
----
18
HHSearch
62.29
16%
-43
- C1 -
4RW0
1
?
A:
[65-184]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
R
H
I
F
L
M
C
G
T
N
D
I
L
Q
G
R
-------------------------
D
-
S
T
Y
V
Y
-
K
T
L
V
K
A
I
E
L
A
S
T
--
K
--
G
M
V
I
I
-
G
L
E
-
T
Q
I
D
S
--
D
M
D
----------
G
L
D
L
V
V
R
E
V
N
E
Q
L
K
A
Y
A
A
E
-
H
N
I
K
V
I
D
F
Y
T
T
-
L
F
E
A
-
D
Q
I
-----
G
Q
I
V
F
A
G
E
V
H
P
N
E
R
G
Y
R
L
-
M
A
Y
K
A
L
E
V
F
T
R
----
24
HHSearch
60.13
11%
-45
- C1 -
1IVN
2
TESA_ECOLI
A:
[54-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
A
-
L
L
-
K
-
Q
-
H
Q
P
R
W
V
L
V
E
L
G
G
N
D
G
L
R
G
F
-------------------------
Q
-
P
Q
Q
T
E
-
Q
T
L
R
Q
I
L
Q
D
V
K
A
--
A
--
N
A
E
P
L
-
L
M
Q
-
I
R
L
P
A
-
N
Y
-------------
G
R
R
Y
N
E
A
F
S
A
I
Y
P
K
L
A
K
E
-
F
D
V
P
L
L
P
F
F
M
E
-
E
V
Y
L
--------
K
P
Q
W
M
Q
D
D
G
I
H
P
N
R
D
A
Q
P
F
-
I
A
D
W
M
A
K
Q
L
Q
P
L
---
31
Fugue
58.98
14%
-21
- C1 -
1VJG
-
?
A:
[5-205]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
T
Q
I
R
I
C
F
V
-
G
D
S
F
V
N
----
G
T
--
G
---------
D
P
E
--------
C
--
L
-----
G
----
W
T
G
R
-
V
C
V
N
A
N
K
K
G
Y
D
V
-
T
Y
Y
N
L
G
I
R
R
D
T
S
S
D
----
I
A
K
R
W
L
Q
E
V
-
S
L
-
R
L
-
H
-
K
-
E
Y
N
S
L
V
V
F
S
F
G
---
L
N
D
T
T
L
E
-
N
G
-
K
P
R
-----------
V
S
I
A
E
T
-
I
K
N
T
R
-
E
I
L
T
Q
A
K
K
L
Y
---------
P
V
L
M
I
S
P
-
A
P
Y
I
E
-
Q
Q
D
P
-
G
---------
R
R
R
R
T
I
D
L
S
Q
Q
L
A
L
V
C
Q
D
L
-
D
V
P
Y
L
D
V
F
P
L
-
L
E
K
P
-
S
V
W
L
H
E
A
K
A
----
N
D
G
V
H
P
Q
A
G
G
Y
T
E
-
F
A
R
I
V
E
N
W
D
A
W
L
N
W
F