@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0131c: (2016-04-19 )
MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLFVTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
Atome Classification :
(20 SA)
.........10..-----......20........30........40........--50-----------...-....---.60------........-.70......-.-.80.....-..--.90........100.-....--...110-----........---.120.......130.......140.......150-.-......160.......170.-.-.....180......--.190-........200-.--.--.---.....210.......220..---.---..-.-.230...--.---...240.......250.......260.......270.......280.......290.......300.......310.......320.......330....---..-----------.340--------------.........350....---...360.......370.......380.......390.......400.......410.......420.......430.......440.....---------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPVRRRAGERL
P
T
-----
V
WDFET
D
P
Q
Y
Q
S
K
L
D
W
V
E
K
F
M
A
EELEP
L
D
L
V
A
LDPY--DK-----------KNA-
D
T
M
A
---
I
L
-------
R
P
L
Q
R
Q
V
K
-DQG
L
W
A
AHL-R-PELGGQG
F
-
G
Q
--
V
K
L
A
L
L
N
E
I
IGRS-R-WAPS--AFGC-------QAPDSGN
A
---
E
I
L
A
L
FGT
D
E
Q
K
A
R
Y
L
R
P
L
LDGE
I
T
S
C
Y
SMTEPQ-G-GSDP
G
L
F
V
T
A
ATRDAAGNG
D
-
W
-
I
I
NGEKWFSTNAK
H
--
A
S
F
--
F
I
V
M
A
VTKPE--A--R--
T
---
Y
E
K
M
S
L
F
I
V
PADTP
G
I
E
I
V
R
---N---VG-V-GAESTRH--A---SHG
Y
I
R
Y
H
D
V
RVP
A
D
HVLGGEG
Q
A
F
M
I
A
Q
TRLGG
G
R
I
H
H
A
M
R
T
I
A
L
A
R
R
A
F
D
M
M
C
E
R
A
L
S
RQTRHGR
L
A
D
L
Q
M
T
Q
E
K
I
A
D
S
W
I
Q
I
E
Q
F
R
L
L
V
L
R
T
A
W
L
ID---KH-----------H
D
----------------
Y
Q
K
V
R
R
D
I
A
A
V
K
V
A
M
P
---
Q
V
L
H
D
V
V
Q
R
A
M
H
L
HGALGVSDE
M
P
F
V
K
M
M
L
A
A
E
SLGIAD
G
A
T
E
L
H
K
M
T
V
A
R
R
T
L
R
E
YQPV
T
T
LFPSQHIP
T
R
R
A
H
A
E
A
W
L
A
Q
R
L
E
H
A
I
AEF---------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.03
36%
-91
- C1 -
2WBI
7
ACD11_HUMAN
A:
[28-419]
----------------------------
Q
E
V
L
I
K
V
K
H
F
M
K
Q
H
I
L
P
A
E
K
E
V
T
E
----------------------
K
W
G
KP
L
V
I
-------
D
K
L
K
E
M
A
K
-
V
E
G
L
W
N
L
F
L
---
P
A
V
S
G
--
L
-
S
H
--
V
D
Y
A
L
I
A
E
E
T
G
K
C
-
F
-
F
A
P
D
--
V
F
N
C
-------
Q
A
P
D
T
G
N
M
---
E
V
L
H
L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
I
T
S
C
F
C
M
T
E
P
D
V
A
-
S
S
D
A
T
N
I
E
C
S
I
Q
R
D
---
E
D
S
-
Y
-
V
I
N
G
K
K
W
W
S
S
G
A
G
N
--
P
K
C
--
K
I
A
I
V
L
G
R
T
Q
--
N
--
T
--
S
LSR
H
K
Q
H
S
M
I
L
V
P
M
N
T
P
G
V
K
I
I
R
---
P
---
L
S
-
V
F
G
Y
T
D
N
F
H
--
G
---
G
H
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
G
E
G
R
G
F
E
I
S
Q
G
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
I
A
F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
---
T
L
-----------
G
S
-----------------
A
G
A
K
K
E
I
A
M
I
K
V
A
A
P
---
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
A
N
M
Y
A
I
T
R
V
L
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
D
--------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.00
37%
-84
- C1 -
4HR3
1
?
A:
[7-412]
---------------------
F
A
P
S
A
R
A
A
E
L
I
A
A
V
R
E
F
I
D
A
E
V
M
P
V
E
R
A
V
L
A
H
H
--
D
E
L
L
G
--------
A
R
A
-
G
T
T
A
---
E
L
W
HVPPE
L
D
S
L
K
A
K
A
R
-
A
A
G
L
W
N
L
F
L
P
D
-
P
E
L
G
G
-
G
L
-
S
N
--
S
E
Y
A
P
L
A
E
Q
M
G
R
S
-
L
-
F
A
P
T
--
V
F
N
C
-------
N
A
P
D
S
G
N
M
---
E
V
L
H
R
Y
G
S
Q
E
Q
K
E
V
W
L
E
P
L
L
E
G
D
I
R
S
A
F
C
M
T
E
P
D
-
V
-
A
S
S
D
A
T
N
M
-
A
A
T
A
V
V
E
G
D
-
E
-
V
-
V
I
N
G
R
K
W
W
S
T
G
V
G
H
PD
C
K
V
--
I
I
F
M
G
L
T
D
P
N
--
A
--
H
--
R
---
Y
A
R
H
S
M
V
L
V
P
M
D
T
P
G
I
T
V
E
R
---
M
---
L
P
-
T
-
M
G
F
Y
D
E
P
--
G
---
G
H
G
V
V
S
F
D
N
V
R
L
P
A
D
A
F
I
A
G
P
G
K
G
F
E
I
A
Q
G
R
L
G
P
G
R
V
H
H
A
M
R
L
I
G
L
A
E
V
A
L
E
H
A
C
R
R
G
L
D
R
T
A
F
G
K
P
L
V
N
L
G
G
N
R
E
R
I
A
D
A
R
I
A
I
N
Q
T
R
L
L
V
L
H
A
A
W
L
L
D
---
T
------------
V
G
----------------
I
M
G
A
L
S
A
V
S
E
I
K
V
A
A
P
---
N
M
A
Q
Q
V
I
D
M
A
I
Q
I
H
G
G
G
G
L
S
N
D
F
P
L
A
A
A
W
V
N
A
R
A
L
R
L
A
D
G
P
D
E
V
H
R
G
V
V
A
R
I
E
L
A
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
84.33
36%
-82
- C1 -
4HR3
1
?
A:
[7-413]
---------------------
F
A
P
S
A
R
A
A
E
L
I
A
A
V
R
E
F
I
D
A
E
V
M
P
V
E
R
A
-
V
L
A
H
--
H
D
E
L
L
G
A
RAGT
T
A
E
L
W
H
V
P
P
E
----
L
-------
D
S
L
K
A
K
A
R
-
A
A
G
L
W
N
L
F
L
-
P
-
D
P
E
L
G
G
G
L
-
S
N
--
S
E
Y
A
P
L
A
E
Q
M
G
R
S
L
F
-
A
P
T
V
F
N
C
N
A
P
-------
D
---
S
G
N
M
---
E
V
L
H
R
Y
G
S
Q
E
Q
K
E
V
W
L
E
P
L
L
E
G
D
I
R
S
A
F
C
M
T
E
P
D
-
V
A
S
S
D
A
T
N
M
A
A
T
A
V
V
E
---
G
D
E
-
V
-
V
I
N
G
R
K
W
W
S
T
G
V
G
H
--
P
D
C
KV
I
I
F
M
G
L
T
D
P
N
--
A
--
H
--
R
---
Y
A
R
H
S
M
V
L
V
P
M
D
T
P
G
I
T
V
E
R
---
M
---
L
P
T
M
-
G
F
Y
---
D
EP
G
---
G
H
G
V
V
S
F
D
N
V
R
L
P
A
D
A
F
I
A
G
P
G
K
G
F
E
I
A
Q
G
R
L
G
P
G
R
V
H
H
A
M
R
L
I
G
L
A
E
V
A
L
E
H
A
C
R
R
G
L
D
R
T
A
F
G
K
P
L
V
N
L
G
G
N
R
E
R
I
A
D
A
R
I
A
I
N
Q
T
R
L
L
V
L
H
A
A
W
L
L
D
---
T
V
-----------
G
I
-----------------
M
G
A
L
S
A
V
S
E
I
K
V
A
A
P
---
N
M
A
Q
Q
V
I
D
M
A
I
Q
I
H
G
G
G
G
L
S
N
D
F
P
L
A
A
A
W
V
N
A
R
A
L
R
L
A
D
G
P
D
E
V
H
R
G
V
V
A
R
I
E
L
A
K
Y
A
------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.94
36%
-89
- C1 -
2WBI
10
ACD11_HUMAN
B:
[28-419]
----------------------------
Q
E
V
L
I
K
V
K
H
F
M
K
Q
H
I
L
P
A
E
K
E
V
T
E
F
Y
V
Q
N
E
-----------
N
S
V
-
D
K
W
G
KP
L
V
I
-------
D
K
L
K
E
M
A
K
-
V
E
G
L
W
N
L
F
L
---
P
A
V
S
G
--
L
-
S
H
--
V
D
Y
A
L
I
A
E
E
T
G
K
C
-
F
-
F
A
P
D
--
V
F
N
C
-------
Q
A
P
D
T
G
N
M
---
E
V
L
H
L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
I
T
S
C
F
C
M
T
E
P
D
V
A
-
S
S
D
A
T
N
I
E
C
S
I
Q
R
D
---
E
D
S
-
Y
-
V
I
N
G
K
K
W
W
S
S
G
A
G
N
--
P
K
C
--
K
I
A
I
V
L
G
R
T
Q
--
N
--
T
--
S
-----
Q
H
S
M
I
L
V
P
M
N
T
P
G
V
K
I
I
R
---
P
---
L
S
-
V
F
G
Y
T
D
N
F
H
--
G
---
G
H
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
G
E
G
R
G
F
E
I
S
Q
G
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
I
A
F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
---
T
L
-----------
G
S
-----------------
A
G
A
K
K
E
I
A
M
I
K
V
A
A
P
---
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
A
N
M
Y
A
I
T
R
V
L
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
D
--------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
81.91
25%
-82
- C1 -
2Z1Q
2
?
B:
[5-577]
K
K
L
W
Q
K
G
G
G
W
L
L
E
VPE
R
V
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
-
L
L
E
R
M
E
H
--------------------
G
E
L
E
---
L
N
-------
V
P
L
M
R
K
A
G
-
E
L
G
L
L
A
I
D
V
-
P
-
E
E
Y
G
G
L
D
L
-
P
K
--
V
I
S
T
V
V
A
E
E
L
S
G
S
-
G
-
G
F
S
V
--
T
Y
G
A
-------
H
T
S
I
G
--
T
---
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
-
S
-
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
-
H
-
Y
-
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
--
A
H
L
--
F
T
V
F
A
K
V
D
G
E
--------------
H
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
---
E
---
E
K
----
K
M
G
I
K
A
--
S
---
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
---
E
A
L
LGKKG
P
E
A
V
M
A
G
----------------
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
---
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
--
R
A
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
Y
G
Q
G
V
EEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
LPRLVEG
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR
43
HHSearch
79.56
34%
-87
- C1 -
2WBI
7
ACD11_HUMAN
A:
[22-423]
----------------------
V
Q
T
R
K
G
Q
E
V
L
I
K
V
K
H
F
M
K
Q
H
I
L
P
A
E
K
E
-
V
T
E
-------------------K
W
G
K
P
---
L
V
-------
I
D
K
L
K
E
M
A
K
V
E
G
L
W
N
L
F
L
-
P
-
A
V
S
G
---
L
-
S
H
--
V
D
Y
A
L
I
A
E
E
T
G
K
C
F
F
A
P
D
V
F
N-
C
Q
A
P
-------
D
---
T
G
N
M
---
E
V
L
H
L
Y
G
S
E
E
Q
K
K
Q
W
L
E
P
L
L
Q
G
N
I
T
S
C
F
C
M
T
E
P
D
-
V
A
S
S
D
A
T
N
I
E
C
S
I
Q
R
D
---
E
D
S
-
Y
-
V
I
N
G
K
K
W
W
S
S
G
A
G
N
PK
C
K
I
--
A
I
V
L
G
R
T
Q
N
T
S-
L
--
S
--
R
---
H
K
Q
H
S
M
I
L
V
P
M
N
T
P
G
V
K
I
I
R
---
P
---
L
S
V
F
-
G
Y
T
---
D
--
N
FHG
G
H
F
E
I
H
F
N
Q
V
R
V
P
A
T
N
L
I
L
G
E
G
R
G
F
E
I
S
Q
G
R
L
G
P
G
R
I
H
H
C
M
R
T
V
G
L
A
E
R
A
L
Q
I
M
C
E
R
A
T
Q
R
I
A
F
K
K
K
L
Y
A
H
E
V
V
A
H
W
I
A
E
S
R
I
A
I
E
K
I
R
L
L
T
L
K
A
A
H
S
M
D
---
T
L
-----------
G
S
-----------------
A
G
A
K
K
E
I
A
M
I
K
V
A
A
P
---
R
A
V
S
K
I
V
D
W
A
I
Q
V
C
G
G
A
G
V
S
Q
D
Y
P
L
A
N
M
Y
A
I
T
R
V
L
R
L
A
D
G
P
D
E
V
H
L
S
A
I
A
T
M
E
L
R
D
Q
A
K
R
----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.88
27%
-90
- C1 -
2JIF
9
ACDSB_HUMAN
A:
[40-404]
----------------------------------
V
K
K
F
A
Q
E
Q
I
A
P
L
----
V
S
T
M
--
D
E
-----------
N
S
K
-
M
E
K
S
---
V
I
-------
Q
G
L
F
Q
Q
-----
G
L
M
G
I
E
V
-
D
-
P
E
Y
G
G
T
G
A
-
S
F
--
L
S
T
V
L
V
I
E
E
L
A
K
V
-
D
-
A
S
V
A
--
V
F
-
C
-------
E
I
Q
N
T
L
I
N
---
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
-
P
Q
L
T
T
E
K
V
G
S
F
C
L
S
E
A
G
-
A
-
G
S
D
S
F
A
L
K
T
R
A
D
K
E
----
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
--
A
G
L
--
F
L
V
M
A
N
V
D
P
T
--
I
-----
G
---
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
PEN
K
---
L
G
-
L
-
R
A
S
S
T
C
P
----------
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
---
A
G
-----------
K
P
----------------
F
I
K
---
E
A
S
M
A
K
Y
Y
A
S
---
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
73.80
27%
-82
- C1 -
3OWA
6
?
A:
[30-431]
--------------------
P
E
D
F
S
S
E
H
K
M
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
E
L
E
Y
-
L
E
Q
H
----------------
E
--
F
D
-----
R
S
-------
V
R
L
L
K
E
A
G
-
E
L
G
L
L
G
A
D
V
-
P
-
E
E
Y
G
G
I
G
L
-
D
K
--
V
S
S
A
L
I
A
E
K
F
S
R
A
G
G
-
F
A
I
T
--
H
G
A
H
-------
V
---
G
I
G
S
---
L
P
I
V
L
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
G
E
K
L
A
A
Y
A
L
T
E
P
G
-
S
-
G
S
D
A
L
G
A
K
T
T
A
R
L
N
A
-
E
G
T
H
-
Y
-
V
L
N
G
E
K
Q
W
I
T
N
S
A
F
--
A
D
V
--
F
I
V
Y
A
K
I
D
G
--------------
E
H
F
S
A
F
I
V
E
K
D
Y
A
G
V
S
T
S
P
---
E
---
E
K
K
M
-
G
I
K
---
C
--
S
---
S
T
R
T
L
I
L
E
D
A
L
V
P
K
E
N
L
L
G
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
E
---
S
R
-----------
M
S
T
LS
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
Y
A
I
E
C
S
L
N
K
V
F
G
S
---
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
V
P
G
T
F
L
R
K
A
M
K
-----------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
72.40
29%
-83
- C1 -
5IDU
7
?
A:
[24-404]
---------------------
P
F
F
E
A
R
H
R
E
L
A
A
G
I
E
A
W
A
T
Q
H
L
A
C
V
--
Q
-
H
D
D
T
---------------
D
T
--
T
C
--------------
R
K
L
V
R
A
L
G
-
E
A
G
W
L
K
Y
G
V
-
G
G
A
Q
Y
G
G
H
G
D
-
T
I
D
T
R
A
V
C
L
L
R
E
T
L
A
N
H
D
G
-
L
A
D
F
--
A
L
A
M
-------
Q
---
G
L
G
S
---
G
A
I
T
L
A
G
T
H
E
Q
K
I
R
Y
L
P
R
V
S
K
G
E
A
I
A
A
F
A
L
S
E
P
D
-
A
-
G
S
D
V
A
A
M
S
L
Q
A
R
A
E
---
G
D
C
-
Y
-
V
I
D
G
D
K
T
W
I
S
N
G
G
I
--
A
D
F
--
Y
V
V
F
A
R
T
G
E
---
A
--
P
--
G
---
A
R
G
I
S
A
F
I
V
D
A
D
T
P
G
L
Q
I
A
E
---
R
---
I
D
V
I
-
A
-----
P
--
H
---
P
L
A
R
L
H
F
D
S
A
R
V
P
R
S
Q
M
L
G
A
P
G
E
G
F
K
I
A
M
R
T
L
D
V
F
R
T
S
V
A
A
A
S
L
G
F
A
R
R
A
L
Q
E
G
L
A
R
A
A
S
R
K
M
F
G
Q
T
L
G
D
F
Q
L
T
Q
T
K
L
A
Q
M
A
L
T
I
D
S
S
A
L
L
V
Y
R
A
A
W
L
R
D
---
Q
G
-----------
E
-------------------
N
V
T
R
E
A
A
M
A
K
W
H
A
S
---
E
G
A
Q
Q
V
I
D
A
A
V
Q
L
W
G
G
M
G
V
Q
S
G
T
T
V
E
R
L
Y
R
E
I
R
A
L
R
I
Y
E
G
A
T
E
V
Q
Q
L
I
V
G
R
D
L
L
K
A
H
A
A
Q
R
---------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
71.60
28%
-77
- C1 -
4P13
3
ACADM_HUMAN
A:
[3-386]
-------------------
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
-
Y
D
K
T
---------------
G
E
--
Y
P
--------------
V
P
L
I
R
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
N
C
G
G
L
G
L
-
G
T
--
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
--
I
-
E
G
-------
N
---
S
L
G
Q
---
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
---
G
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
--
P
KA
P
--
A
---
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
---
K
---
E
L
N
M
-
G
Q
R
---
C
--
S
---
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
-----------
R
-------------------
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
---
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.53
29%
-86
- C1 -
1EGD
3
ACADM_HUMAN
A:
[12-395]
-------------------
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
K
----------------
T
G
E
---
Y
P
-------
V
P
L
I
R
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
N
C
G
G
L
G
L
-
G
T
--
F
D
A
C
L
I
S
E
E
L
------------
A
Y
G
C
T
G
V
----
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
---------------------------------
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.28
29%
-84
- C1 -
1EGC
5
ACADM_HUMAN
A:
[12-395]
-------------------
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
K
----------------
T
G
E
---
Y
P
-------
V
P
L
I
R
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
N
C
G
G
L
G
L
-
G
T
--
F
D
A
C
L
I
S
E
E
L
------------
A
Y
G
C
T
G
V
----
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
KEL
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
---------------------------------
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.26
29%
-86
- C1 -
2A1T
3
ACADM_HUMAN
A:
[37-420]
-------------------
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
K
----------------
T
G
E
---
Y
P
-------
V
P
L
I
R
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
N
C
G
G
L
G
L
-
G
T
--
F
D
A
C
L
I
S
E
E
L
------------
A
Y
G
C
T
G
V
----
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
KEL
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
---------------------------------
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.17
29%
-87
- C1 -
1EGE
3
ACADM_HUMAN
A:
[12-395]
-------------------
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
K
----------------
T
G
E
---
Y
P
-------
V
P
L
I
R
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
N
C
G
G
L
G
L
-
G
T
--
F
D
A
C
L
I
S
E
E
L
------------
A
Y
G
C
T
G
V
----
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
KEL
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
---------------------------------
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
69.99
28%
-77
- C1 -
3MDD
2
ACADM_PIG
A:
[1-385]
------------------
G
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
----
V
A
A
E
Y
--
D
R
-----------
T
G
---
E
Y
P
------------
V
P
L
L
K
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
S
F
G
G
L
G
-L
G
I
--
I
D
S
C
L
I
T
E
E
L
A
Y
G
-
C
--
T
G
V
--
Q
T
A
I
-------
E
A
N
T
-
L
G
Q
---
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
-
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
--
P
--
K
AP
A
---
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
---
K
---
E
I
----
N
M
G
Q
R
C
--
S
---
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
---
S
G
-----------
R
R
----------------
N
---
T
Y
Y
A
S
I
A
K
A
Y
A
A
---
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.86
29%
-83
- C1 -
1T9G
3
ACADM_HUMAN
A:
[12-395]
-------------------
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
K
----------------
T
G
E
---
Y
P
-------
V
P
L
I
R
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
N
C
G
G
L
G
L
-
G
T
--
F
D
A
C
L
I
S
E
E
L
------------
A
Y
G
C
T
G
V
----
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
KEL
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
---
S
G
---------------------------------
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.56
30%
-90
- C1 -
2VIG
5
ACADS_HUMAN
A:
[44-384]
---------------------------------------------------------------------------------------------
K
K
M
G
-
G
L
G
L
L
A
M
D
V
-
P
-
E
E
L
G
G
A
G
L
-
D
Y
--
L
A
Y
A
I
A
M
E
E
I
S
R
G
---
C
A
S
T
--
G
V
I
M
-------
S
V
N
N
S
L
Y
L
---
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
-
N
-
G
S
D
A
G
----
A
A
S
T
T
A
R
A
E
G
D
S
W
-
V
L
N
G
T
K
A
W
I
T
N
A
W
E
--
A
S
A
--
A
V
V
F
A
S
T
D
-
R
--
A
--
L
--
Q
---
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
---
K
EDK
L
G
-
I
------
R
G
--
S
---
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
---
N
K
-----------
K
P
----------------
F
I
K
---
E
A
A
M
A
K
L
A
A
S
---
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
S
Y
R
S
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.36
28%
-83
- C1 -
3MDD
2
ACADM_PIG
A:
[2-385]
-------------------
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
R
-----------
T
G
E
-
Y
P
V
--------------
P
L
L
K
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
S
F
G
G
L
G
L
-
G
I
--
I
D
S
C
L
I
T
E
E
L
------------
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
---
P
L
I
-
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
KEI
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
GR
R
N
-----------
T
Y
----------------
Y
A
S
I
A
K
A
Y
A
A
---------
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.26
28%
-83
- C1 -
3MDE
3
ACADM_PIG
A:
[2-385]
-------------------
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
---
V
A
A
E
-
Y
--
D
R
-----------
T
G
E
-
Y
P
V
--------------
P
L
L
K
R
A
W
-
E
L
G
L
M
N
T
H
I
-
P
-
E
S
F
G
G
L
G
L
-
G
I
--
I
D
S
C
L
I
T
E
E
L
------------
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
---
P
L
I
-
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
-
A
-
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
---
D
E
-
Y
-
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
--
A
N
W
--
Y
F
L
L
A
R
S
D
P
D
PK
A
--
P
--
A
---
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
KEI
N
---
M
G
-
Q
-
R
C
S
D
T
R
G
----------
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
GR
R
N
-----------
T
Y
----------------
Y
A
S
I
A
K
A
Y
A
A
---------
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
68.02
22%
-81
* C1 *
1RX0
8
ACAD8_HUMAN
A:
[15-392]
-------------------
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
-
W
D
Q
K
---------------
E
L
--
F
P
--------------
V
D
V
M
R
K
A
A
-
Q
L
G
F
G
G
V
Y
I
-
Q
-
T
D
V
G
G
S
G
L
-
S
R
--
L
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
T
T
A
Y
--
I
S
I
H
-----------
N
M
C
A
---
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
-
S
-
G
S
D
A
A
S
L
L
T
S
A
K
K
Q
---
G
D
H
-
Y
-
I
L
N
G
S
K
A
F
I
S
G
A
G
E
--
S
D
I
--
Y
V
V
M
C
R
T
G
G
------
P
--
G
---
P
K
G
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
---
K
---
E
K
K
V
-
G
W
N
---
S
--
Q
---
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
---
E
E
-----------
R
K
------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
---
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------