@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0147: (2016-04-19 )
MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEKQTDVAKTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLDRNPFEAYLADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPGRGWVEYEPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRLSGYLAAAKTDAAADGGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVTVKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQVSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPPYTERAIKVARRLF
Atome Classification :
(23 SA)
.........10........20........30......---..40........50........60.---.......70........80........90........100.......110.....---..120.......130.......140.......150.......160--........170.......180.......190.......200.....------...210.......220--.-......230.......240...-....250.......260.......270.......280.......290.......300.......310....----...--320----.--..----......330.......340....--...350.....-..360-.......370.......380.......390.......400.......410.......420.......430......-.440.......450.......460.......470.......480....-..-..490........500....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDRV
K
A
VAPPDG
R
T
M
M
T
T
E
S
V
A
R
K
TQKSETEAPREP---APVS
D
E
K
Q
T
D
V
A
K
T
V
A
R
L
R
K
T
F
ASG---RTR
S
V
E
W
R
K
Q
Q
L
R
A
L
Q
K
L
M
DEN
E
D
A
I
A
A
A
L
A
E
D
LDR
N
P
F
E
A
Y
L
A
D
I
ATT
S
A
E
A
K
Y
---
A
A
K
R
V
R
R
W
M
R
R
R
Y
L
L
L
EVPQLPGRG
W
V
E
YEPY
G
T
V
L
I
I
GAWNY
P
---
F
Y
L
T
LGPAVGAIAAG
N
A
V
V
L
K
P
S
E
I
A
A
A
S
A
H
L
M
T
E
L
V
Y
R
Y-LDT
E
A
------
I
A
V
V
QGDG
A
V
S
Q
E
L
I
A
--
Q
-
G
F
D
R
V
M
FTG
G
T
E
I
G
R
K
V
YEGAA-PHL
T
P
V
T
L
E
LGGKS
P
V
I
V
A
ADA
D
V
D
V
A
A
K
R
I
A
W
I
KLLNAGQTCVAPD
Y
V
LAD
A
T
V
R
D
E
L
V
S
K
I
T
A
A
L
T
K
F
R----SGA--P------
Q
--
G
M
----
R
I
V
N
Q
R
Q
F
D
R
L
S
G
Y
L
AAAKTDAA--ADGG
G
V
V
V
GGD-CDASN-
L
R
I
Q
P
T
V
V
VDPDPDGPLMSNEIFGPILP
V
V
T
V
K
S
L
D
D
A
I
R
F
V
NSRPKP
L
S
A
Y
L
FT
K
S
R
A
V
R
E
R
V
I
R
EVPAG
G
M
M
V
N
-
H
L
A
F
Q
V
STAKLPFGGVGASGMGAYHGRWG
F
E
E
F
S
H
R
K
S
V
LTKP-TRPD-
L
S
-SFI-YPPY
T
E
R
A
I
K
V
A
R
R
LF
70
HHSearch
98.11
41%
-104
- C3 -
4QGK
-
AL3A2_HUMAN
A:
[1-449]
--------------------------------------------------
M
E
L
E
V
R
R
V
R
Q
A
F
L
S
G
---
R
S
R
P
L
R
F
R
L
Q
Q
L
E
A
L
R
R
M
V
Q
E
R
E
K
D
I
L
T
A
I
A
A
D
L
C
K
S
E
F
N
V
Y
S
Q
E
V
I
T
V
L
G
E
I
D
F
---
M
L
E
N
L
P
E
W
V
T
A
K
P
V
K
K
N
V
L
T
M
L
D
E
A
Y
I
Q
P
Q
P
L
G
V
V
L
I
I
G
A
W
N
Y
P
---
F
V
L
T
I
Q
P
L
I
G
A
I
A
A
G
N
A
V
I
I
K
P
S
E
L
S
E
N
T
A
K
I
L
A
K
L
L
P
Q
Y
-
L
D
Q
D
L
------
Y
I
V
I
N
G
G
V
E
E
T
T
E
L
L
K
--
Q
-
R
F
D
H
I
F
Y
T
G
N
T
A
V
G
K
I
V
M
E
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
I
D
K
D
C
D
L
D
I
V
C
R
R
I
T
W
G
K
Y
M
N
C
G
Q
T
C
I
A
P
D
Y
I
L
C
E
A
S
L
Q
N
Q
I
V
W
K
I
K
E
T
V
K
E
F
Y
----
G
E
N
IK
E
------
S
PD
Y
E
----
R
I
I
N
L
R
H
F
K
R
I
L
S
L
L
E
-----------
G
Q
K
I
A
F
G
G
E
-
T
D
E
A
T
-
R
Y
I
A
P
T
V
L
T
D
V
D
P
K
T
K
V
M
Q
E
E
I
F
G
P
I
L
P
I
V
P
V
K
N
V
D
E
A
I
N
F
I
N
E
R
E
K
P
L
A
L
Y
V
F
S
H
N
H
K
L
I
K
R
M
I
D
E
T
S
S
G
G
V
T
G
N
-
D
V
I
M
H
F
T
L
N
S
F
P
F
G
G
V
G
S
S
G
M
G
A
Y
H
G
K
H
S
F
D
T
F
S
H
Q
R
P
C
L
L
K
S
-
L
K
R
E
G
A
N
-
K
L
R
-
Y
P
P
N
S
Q
S
K
V
D
------
72
HHSearch
97.56
43%
-105
- C3 -
3SZA
4
AL3A1_HUMAN
A:
[18-463]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
AK
K
------
S
RD
Y
G
----
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
E
-----------
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
E
G
L
-
K
V
R
-
Y
P
P
S
P
-----------
7
PsiBlast_PDB
97.06
40%
-103
- C3 -
4QGK
-
AL3A2_HUMAN
A:
[5-448]
------------------------------------------------------
V
R
R
V
R
Q
A
F
L
S
G
---
R
S
R
P
L
R
F
R
L
Q
Q
L
E
A
L
R
R
M
V
Q
E
R
E
K
D
I
L
T
A
I
A
A
D
L
C
K
S
E
F
N
V
Y
S
Q
E
V
I
T
V
L
G
E
I
D
F
---
M
L
E
N
L
P
E
W
V
T
A
K
P
V
K
K
N
V
L
T
M
L
D
E
A
Y
I
Q
P
Q
P
L
G
V
V
L
I
I
G
A
W
N
Y
P
---
F
V
L
T
I
Q
P
L
I
G
A
I
A
A
G
N
A
V
I
I
K
P
S
E
L
S
E
N
T
A
K
I
L
A
K
L
L
P
Q
Y
-
L
D
Q
D
L
------
Y
I
V
I
N
G
G
V
E
E
T
T
E
L
L
K
--
Q
-
R
F
D
H
I
F
Y
T
G
N
T
A
V
G
K
I
V
M
E
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
I
D
K
D
C
D
L
D
I
V
C
R
R
I
T
W
G
K
Y
M
N
C
G
Q
T
C
I
A
P
D
Y
I
L
C
E
A
S
L
Q
N
Q
I
V
W
K
I
K
E
T
V
K
E
F
Y
GENI
K
E
S
--
P
------
D
--
Y
E
----
R
I
I
N
L
R
H
F
K
R
I
L
S
L
L
-----------
E
G
Q
K
I
A
F
G
G
E
-
T
D
E
A
T
-
R
Y
I
A
P
T
V
L
T
D
V
D
P
K
T
K
V
M
Q
E
E
I
F
G
P
I
L
P
I
V
P
V
K
N
V
D
E
A
I
N
F
I
N
E
R
E
K
P
L
A
L
Y
V
F
S
H
N
H
K
L
I
K
R
M
I
D
E
T
S
S
G
G
V
T
G
N
-
D
V
I
M
H
F
T
L
N
S
F
P
F
G
G
V
G
S
S
G
M
G
A
Y
H
G
K
H
S
F
D
T
F
S
H
Q
R
P
C
L
L
K
S
L
K
R
E
G
-
A
N
-
K
L
R
-
Y
P
P
N
S
Q
S
K
V
-------
21
PsiBlast_CBE
96.89
44%
-103
- C3 -
1AD3
1
AL3A1_RAT
B:
[3-430]
--------------------------------------------------
I
S
D
T
V
K
R
A
R
E
A
F
N
S
G
---
K
T
R
S
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
M
I
N
E
N
L
K
S
I
S
G
A
L
A
S
D
L
G
K
N
E
W
T
S
Y
Y
E
E
V
A
H
V
L
E
E
L
D
T
---
T
I
K
E
L
P
D
W
A
E
D
E
P
V
A
K
T
R
Q
T
Q
Q
D
D
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
A
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
V
A
A
G
N
A
V
I
L
K
P
S
E
V
S
G
H
M
A
D
L
L
A
T
L
I
P
Q
Y
-
M
D
Q
N
L
------
Y
L
V
V
K
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
M
Y
T
G
S
T
A
V
G
K
I
V
M
A
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
D
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
D
F
Y
G---
E
D
A
--
K
------
Q
--
S
R
DYG-
R
I
I
N
D
R
H
F
Q
R
V
K
G
L
I
-----------
D
N
Q
K
V
A
H
G
G
T
-
W
D
Q
S
S
-
R
Y
I
A
P
T
I
L
V
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
M
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
V
F
S
N
N
E
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
T
A
N
-
D
V
I
V
H
I
T
V
P
T
L
P
F
G
G
V
G
N
S
G
M
G
A
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
K
------------------------------
6
PsiBlast_PDB
96.87
42%
-105
- C3 -
4L1O
5
AL3A1_HUMAN
A:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RD
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
2
PsiBlast_PDB
96.81
42%
-104
- C3 -
3SZA
4
AL3A1_HUMAN
A:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RD
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
29
PsiBlast_CBE
96.74
42%
-105
- C3 -
4H80
2
AL3A1_HUMAN
E:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
22
PsiBlast_CBE
96.71
42%
-104
- C3 -
4L2O
6
AL3A1_HUMAN
G:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
26
PsiBlast_CBE
96.64
42%
-105
- C3 -
4H80
2
AL3A1_HUMAN
H:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
27
PsiBlast_CBE
96.60
42%
-105
- C3 -
4H80
2
AL3A1_HUMAN
G:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
73
Fugue
96.59
43%
-104
- C3 -
1AD3
1
AL3A1_RAT
A:
[2-447]
-------------------------------------------------
S
I
S
D
T
V
K
R
A
R
E
A
F
N
S
G
KT-
R
--
S
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
M
I
N
E
N
L
K
S
I
S
G
A
L
A
S
D
L
G
K
N
E
W
T
S
Y
Y
E
E
V
A
H
V
L
E
E
L
D
T
---
T
I
K
E
L
P
D
W
A
E
D
E
P
V
A
K
T
R
Q
T
Q
Q
D
D
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
A
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
V
A
A
G
N
A
V
I
L
K
P
S
E
V
S
G
H
M
A
D
L
L
A
T
L
I
P
Q
Y
-
M
D
Q
N
L
------
Y
L
V
V
K
G
G
-
V
P
E
T
T
E
L
L
--
K
E
R
F
D
H
I
M
Y
T
G
S
T
A
V
G
K
I
V
M
A
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
D
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
D
F
Y
----
G
E
D
--
A
------
K
--
Q
S
RD
Y
G
R
I
I
N
D
R
H
F
Q
R
V
K
G
L
I
D
-----------
N
Q
K
V
A
H
G
G
T
--
W
D
Q
S
S
R
Y
I
A
P
T
I
L
V
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
M
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
V
F
S
N
N
E
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
T
A
N
-
D
V
I
V
H
I
T
V
P
T
L
P
F
G
G
V
G
N
S
G
M
G
A
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
K
S
-
L
L
N
E
-
E
A
H
K
A
R
-
Y
P
P
S
P
A
----------
28
PsiBlast_CBE
96.58
42%
-105
- C3 -
4H80
2
AL3A1_HUMAN
F:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
5
PsiBlast_PDB
96.52
42%
-103
- C3 -
4L2O
6
AL3A1_HUMAN
A:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RD
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
1
PsiBlast_PDB
96.47
44%
-106
- C3 -
1AD3
1
AL3A1_RAT
A:
[3-430]
--------------------------------------------------
I
S
D
T
V
K
R
A
R
E
A
F
N
S
G
---
K
T
R
S
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
M
I
N
E
N
L
K
S
I
S
G
A
L
A
S
D
L
G
K
N
E
W
T
S
Y
Y
E
E
V
A
H
V
L
E
E
L
D
T
---
T
I
K
E
L
P
D
W
A
E
D
E
P
V
A
K
T
R
Q
T
Q
Q
D
D
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
A
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
V
A
A
G
N
A
V
I
L
K
P
S
E
V
S
G
H
M
A
D
L
L
A
T
L
I
P
Q
Y
-
M
D
Q
N
L
------
Y
L
V
V
K
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
M
Y
T
G
S
T
A
V
G
K
I
V
M
A
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
D
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
D
F
Y
G---
E
D
A
--
K
------
Q
--
S
R
D
Y
G
-
R
I
I
N
D
R
H
F
Q
R
V
K
G
L
I
-----------
D
N
Q
K
V
A
H
G
G
T
-
W
D
Q
S
S
-
R
Y
I
A
P
T
I
L
V
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
M
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
V
F
S
N
N
E
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
T
A
N
-
D
V
I
V
H
I
T
V
P
T
L
P
F
G
G
V
G
N
S
G
M
G
A
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
K
------------------------------
3
PsiBlast_PDB
96.43
42%
-103
- C3 -
3SZB
5
AL3A1_HUMAN
A:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RD
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
33
PsiBlast_CBE
96.40
42%
-105
- C3 -
3SZB
5
AL3A1_HUMAN
B:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
23
PsiBlast_CBE
96.32
42%
-102
- C3 -
4L2O
5
AL3A1_HUMAN
E:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
31
PsiBlast_CBE
96.29
42%
-106
- C3 -
4H80
2
AL3A1_HUMAN
C:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
34
PsiBlast_CBE
96.18
42%
-105
- C3 -
3SZA
4
AL3A1_HUMAN
B:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
4
PsiBlast_PDB
96.17
42%
-104
- C3 -
4H80
2
AL3A1_HUMAN
A:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RD
Y
G
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
25
PsiBlast_CBE
96.04
42%
-103
- C3 -
4L1O
5
AL3A1_HUMAN
B:
[18-461]
------------------------------------------------
S
K
I
S
E
A
V
K
R
A
R
A
A
F
S
S
G
---
R
T
R
P
L
Q
F
R
I
Q
Q
L
E
A
L
Q
R
L
I
Q
E
Q
E
Q
E
L
V
G
A
L
A
A
D
L
H
K
N
E
W
N
A
Y
Y
E
E
V
V
Y
V
L
E
E
I
E
Y
---
M
I
Q
K
L
P
E
W
A
A
D
E
P
V
E
K
T
P
Q
T
Q
Q
D
E
L
Y
I
H
S
E
P
L
G
V
V
L
V
I
G
T
W
N
Y
P
---
F
N
L
T
I
Q
P
M
V
G
A
I
A
A
G
N
A
V
V
L
K
P
S
E
L
S
E
N
M
A
S
L
L
A
T
I
I
P
Q
Y
-
L
D
K
D
L
------
Y
P
V
I
N
G
G
V
P
E
T
T
E
L
L
K
--
E
-
R
F
D
H
I
L
Y
T
G
S
T
G
V
G
K
I
I
M
T
A
A
A
-
K
H
L
T
P
V
T
L
E
L
G
G
K
S
P
C
Y
V
D
K
N
C
D
L
D
V
A
C
R
R
I
A
W
G
K
F
M
N
S
G
Q
T
C
V
A
P
D
Y
I
L
C
D
P
S
I
Q
N
Q
I
V
E
K
L
K
K
S
L
K
E
F
Y
----
G
E
D
--
A
------
K
--
K
S
RDYG
R
I
I
S
A
R
H
F
Q
R
V
M
G
L
I
-----------
E
G
Q
K
V
A
Y
G
G
T
-
G
D
A
A
T
-
R
Y
I
A
P
T
I
L
T
D
V
D
P
Q
S
P
V
M
Q
E
E
I
F
G
P
V
L
P
I
V
C
V
R
S
L
E
E
A
I
Q
F
I
N
Q
R
E
K
P
L
A
L
Y
M
F
S
S
N
D
K
V
I
K
K
M
I
A
E
T
S
S
G
G
V
A
A
N
-
D
V
I
V
H
I
T
L
H
S
L
P
F
G
G
V
G
N
S
G
M
G
S
Y
H
G
K
K
S
F
E
T
F
S
H
R
R
S
C
L
V
R
P
-
L
M
N
D
-
E
G
-
L
K
V
R
Y
P
P
-------------
19
PsiBlast_PDB
81.71
31%
-75
- C3 -
4PXL
5
?
B:
[47-509]
-------------------
D
A
V
S
G
K
T
--
F
E
T
R
D
P
R
T
G
EVI
A
S
I
A
E
G
D
K
A
D
V
D
L
A
V
K
A
A
R
E
A
F
D
N
G
PWP
R
M
T
G
Y
E
-
R
G
R
I
L
H
R
F
A
D
L
I
D
E
H
V
E
E
L
A
A
L
D
T
V
D
A
G
K
L
F
A
V
G
K
A
R
D
I
P
G
A
A
H
L
L
R
Y
Y
A
G
A
A
D
K
V
H
G
A
T
L
K
M
A
Q
R
M
-------
H
G
Y
T
L
K
E
P
V
G
V
V
G
H
I
V
P
W
N
Y
P
T
T
M
F
F
F
K
V
G
P
A
---
L
A
A
G
C
A
V
V
V
K
P
A
E
Q
T
P
L
S
A
-----
L
F
Y
A
H
-
L
A
R
E
A
GVPAGV
L
N
V
V
P
G
F
G
P
T
A
G
A
A
V
A
A
H
M
-
D
V
D
K
V
S
F
T
G
S
T
E
V
G
R
L
V
M
R
A
A
A
E
S
N
L
K
P
V
S
L
E
L
G
G
K
S
P
V
I
V
F
D
D
A
D
L
D
M
A
V
N
L
V
N
F
A
T
Y
T
N
K
G
E
I
C
V
A
G
T
R
I
Y
V
Q
E
G
I
Y
D
E
F
V
K
K
A
A
E
L
A
S
K
S
V
----
V
G
D
--
P
FNPSVS
Q
--
G
P
----
Q
-
V
D
K
D
Q
Y
E
K
V
L
R
Y
I
D
I
G
K
R
E
G
A
--
T
----
L
V
T
G
G
K
P
C
G
D
K
G
-
Y
Y
I
E
P
T
I
F
T
D
V
K
D
D
M
T
I
A
Q
D
E
I
F
G
P
V
M
A
L
M
K
F
K
T
V
E
E
V
I
Q
K
A
N
N
T
R
Y
G
L
A
A
G
I
V
T
K
N
I
D
V
A
N
T
V
S
R
S
I
R
A
G
A
I
W
I
N
C
Y
F
A
F
D
P
D
A
---
P
F
G
G
Y
K
M
S
G
F
G
K
D
M
G
M
D
A
L
D
K
Y
L
Q
T
K
T
V
V
T
-------------------------------
44
PsiBlast_CBE
73.47
33%
-93
- C3 -
3B4W
10
?
A:
[138-479]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
S
I
V
S
R
E
P
V
G
V
V
G
A
I
V
A
W
N
V
P
---
L
F
L
A
V
N
K
I
A
P
A
L
L
A
G
C
T
I
V
L
K
P
A
A
E
T
P
L
T
A
N
A
L
A
E
V
F
A
E
V
G
L
P
E
G
V
------
L
S
V
V
P
G
G
I
E
T
G
Q
A
L
T
S
--
N
P
D
I
D
M
F
T
F
T
G
S
S
A
V
G
R
E
V
G
R
R
A
A
-
E
M
L
K
P
C
T
L
E
L
G
G
K
S
A
A
I
I
L
E
D
V
D
L
A
A
A
I
P
M
M
V
F
S
G
V
M
N
A
G
Q
G
C
V
N
Q
T
R
I
L
A
P
R
S
R
Y
D
E
I
V
A
A
V
T
N
F
V
T
A
L
P
----
V
G
P
--
P
SDPAA-
Q
--
I
G
----
P
L
I
S
E
K
Q
R
T
R
V
E
G
Y
I
A
K
G
I
E
E
G
A
R
L
V
C
G
G
G
R
P
E
G
L
D
----
N
G
-
F
F
I
Q
P
T
V
F
A
D
V
D
N
K
M
T
I
A
Q
E
E
I
F
G
P
V
L
A
I
I
P
Y
D
T
E
E
D
A
I
A
I
A
N
D
S
V
Y
G
L
A
G
S
V
W
T
T
D
V
P
K
G
I
K
I
S
Q
Q
I
R
T
G
T
Y
G
I
N
-
W
Y
A
F
D
P
G
S
---
P
F
G
G
Y
K
N
S
G
I
G
R
E
N
G
P
E
G
V
E
H
F
T
Q
Q
K
S
V
L
--------------------------------