@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0312: (2016-04-21 )
MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPSQNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSEIAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSVVGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDLIQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQPGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDRELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSAVVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG
Atome Classification :
(20 SA)
.........10........20.--.----------.----------..-------....--30........40........50........60....--------------...----------------------.--------------------------70---------------------------..---..-----...---..80........90.....--.--..100-------..-------.....110.......120.......130..-.....140.......150.-----.--.-----....---160.......170.......180.......190.......200.......210......--.220.......230.......240......--.250--....-----....--.------260........270.......280.......290.......300.......310.......320-.--....-.-..330------.........340.......350.---......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYDPLG
L
S
IGT
T
N
L
V
AAGNG-G--P----------P----------V
T
-------
R
R
A
V
--
L
T
LYPHCAPKIGVPSQNPNLIE
P
G
A
L
M
S
G
F
V
E
RIG
D
--------------
A
V
A
----------------------
L
--------------------------V----------------------------SP---DG-----SVH---D
P
D
L
L
L
V
E
A
L
D
A
M
V
L
TAGA--D--ASSS
E
-------
I
A
-------
I
A
VPAHWKP
G
A
V
H
A
L
R
N
G
L
R
T
H
V
G
F
V
RSGM-A
P
R
L
V
S
D
A
I
A
A
L
T
A
V
N
SEL-----G--L-----PHG
S
---
V
V
G
L
L
DFGGS
A
T
Y
V
T
L
V
ETKSDSRTSDFQPVS
A
T
A
R
YQDFSG
S
Q
I
D
Q
A
L
L
L
R
V
I
D
QFGY--GDDVDP
A
S
T
A
A
V
G
Q
L
G
Q
L
R
E
Q
C
R
A
A
K
E
R
LS--
T
D
----
V
A
T
E
-----
L
F
A
E
--
L
------AG-CS
S
S
I
E
M
T
R
E
Q
L
E
D
L
I
QDP
L
T
G
F
I
Y
A
F
D
D
M
L
A
RHNA
S
W
A
D
L
A
A
V
V
T
VGGGANI
P
L
V
T
QRL--S--FHTR-R-PVL--------TASQP
G
C
A
A
A
M
G
A
L
L
L
ANRGGER---DSRTRTSIGLATAAAAG
T
S
V
I
ELPAG
D
V
M
V
I
DHEALTDRELAWSQTDFPSEAPARFEGDSYNEGGP
C
W
S
M
R
LNAVEPPKGPA
W
R
R
I
R
V
S
Q
L
L
I
G
V
S
A
V
V
A
M
T
AIG
G
V
A
L
T
L
T
A
I
ERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAPLPSAAPAPTTVAPAPPPPT
Q
V
V
T
TTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVTTTSTIPTIPTT
T
T
T
V
K
M
T
T
E
W
L
HVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG
21
HHSearch
88.59
22%
-83
- C3 -
3D2F
4
?
A:
[2-391]
-
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
-
N
--
R
G
I
D
I
V
V
N
EVS
N
----------
R
S
-------
T
P
S
V
--
V
G
F
G
P
K
-
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
--------------
D
Y
H
HPD
F
E
Q
E
S
K
H
FT
S
K
--------
L
--------------------------
V
E
L
DDK
K
T
G
A
E
V
R
F
---------------
A
G
---
E
K
-----
H
V
F
---
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
--
A
N
I
T
D
-------
V
C
-------
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
-
A
G
L
N
P
-----
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
-----
T
--
D
LPEGE
E
K
P
R
---
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
----
G
Q
L
K
V
L
G
-
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
--
K
Y
K
I
D
I
R
--
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
--
A
N
----
T
N
A
P
-----
F
S
V
E
--
S
VM----
N
D
-
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
--
S
--
E
A
F
G
-
K
-
P
L
S
--------
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
87.18
22%
-80
- C3 -
4JNE
9
DNAK_ECOLI
A:
[1-384]
S
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
-
G
T-
T
P
R
V
L
E
N
AEG-
D
----------
R
T
-------
T
P
S
I
--
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
--------------
R
F
Q
----------------------
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
---
V
----------------------------
E
V
---
K
G
-----
Q
K
M
---
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
--
E
P
V
T
E
-------
A
V
-------
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
-
A
G
L
E
V
-----
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-----
G
--------
T
G
N
R
---
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
A
-
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
--
D
Q
G
I
D
L
R
--
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
--
S
A
----
Q
Q
T
D
-----
V
N
L
P
--
Y
ITADAT
G
P
-
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
--
A
--
E
F
F
G
-
K
-
E
P
R
--------
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
82.84
20%
-85
- C3 -
2V7Y
2
DNAK_GEOKA
A:
[1-353]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
-
G
G-
E
V
---------
K
V
I
P
N
PEGN--
R
T
-------
T
P
S
V
--
V
A
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
--------------
D
Y
K
----------------------
V
-------------------------------------------------------
E
I
---
E
G
-----
K
Q
Y
---
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
--
Y
L
G
E
P
V
T
R
-------
A
V
-------
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
-
A
G
L
E
V
-----
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--------------
E
E
D
Q
---
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
D
----
G
V
F
E
V
K
A
-
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
--
E
H
G
I
D
L
S
--
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
--
G
V
----
T
Q
T
Q
-----
I
S
L
P
--
F
ISANEN
G
P
-
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
--
K
--
R
E
L
G
-
K
-
E
P
H
--------
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
81.84
22%
-88
- C3 -
4RTF
2
?
D:
[35-389]
--
R
A
V
G
I
D
L
G
T
T
N
S
V
V
S
V
L
E
-
G
GD
P
VVVANSEG--
S
----------
R
T
-------
T
P
S
I
--
V
A
F
A
R
N
G
E
V
L
V
G
Q
P
A
K
N
Q
A
V
T
N
V
D
R
T
V
R
S
V
K
R
H
M
G
S
--------------
D
W
S
-------------------------------------------------
I
----------------------------
E
I
---
D
G
-----
K
K
Y
---
T
A
P
E
I
S
A
R
I
L
M
K
L
K
R
D
A
E
A
YL
G
--
E
D
I
T
D
-------
A
V
-------
I
T
T
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
Q
I
-
A
G
L
N
V
-----
L
R
I
V
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
---------------
K
E
Q
---
R
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
E
I
G
-----
G
V
V
E
V
R
A
-
T
S
G
D
N
H
L
G
G
D
D
W
D
Q
R
V
V
D
W
L
V
D
K
F
K
G
--
T
S
G
I
D
L
T
--
K
D
K
M
A
M
Q
R
L
R
E
A
A
E
K
A
K
I
E
L
S
--
S
S
----
Q
S
T
S
-----
I
N
L
P
--
Y
ITVD--
N
P
-
L
F
L
D
E
Q
L
T
R
A
E
F
Q
R
I
T
Q
D
L
L
D
R
T
R
K
P
F
Q
S
V
I
A
D
T
G
I
S
V
S
E
I
D
H
V
V
L
V
G
G
S
T
R
M
P
A
V
T
D
L
V
--
K
--
E
L
T
G
-
G
K
E
P
N
--------
K
G
V
N
P
D
E
V
V
A
V
G
A
A
L
Q
A
G
V
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
81.55
17%
-55
- C3 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
--
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
-
N
--
R
----------
G
----------
I
D
I
V
V
N
EVS
N
R
S
T
PS
V
V
G
F
G
P
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
DYHHPD
F
E
Q
E
S
K
H
F
T
S
K
----------------------
L
--------------------------
V
----------------------------
E
L
---
D
D
K
K
T
G
A
E
V
R
FAG
E
K
H
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
--
D
--
T
V
K
Q
D
TK
A
N
I
T
D
V
C
-------
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
-
A
G
L
----
N
-
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
TDLPE
G
--
E
-----
E
K
P
R
---
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G
-----
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
--
K
Y
K
I
D
I
R
E
N
P
K
A
--
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
--
A
N
----
T
N
A
P
-----
F
S
V
E
SV
M
------
N
D
-
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
--
S
--
E
A
F
G
-
K
-
P
L
S
--------
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
Q
V
E
D
E
-----------------
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
--
T
G
D
F
S
M
A
A
S
Y
T
D
I
T
Q
L
P
P
N
T
P
E
---------------
Q
I
A
N
W
E
I
T
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
-
H
T
I
E
E
A
Y
T
I
E
D
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
G
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
D
E
G
F
D
S
I
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
--
28
HHSearch
80.17
18%
-84
- C3 -
4GNI
1
?
A:
[14-403]
--
V
V
I
G
I
T
F
G
N
S
N
S
S
I
A
H
T
V
D
D
--
K
A
E
V
I
A
N
EDG-
D
----------
R
Q
-------
I
P
T
I
--
L
S
Y
V
D
G
-
D
E
Y
Y
G
Q
Q
A
K
N
F
L
V
R
N
P
K
N
T
V
A
Y
F
R
D
I
L
G
Q
--------------
D
F
K
----------------------
S
--------------------------
V
DPTHNHA
S
A
H
P
Q
E
A
GD
N
V
V
F
T
I
KDKAEE
D
A
---
E
P
-----
S
T
L
---
T
V
S
E
I
A
T
R
Y
L
R
R
L
V
G
A
A
S
E
Y
L
G
--
K
K
V
T
S
-------
A
V
-------
I
T
I
P
T
N
F
T
E
K
Q
K
A
A
L
I
A
A
A
A
A
-
A
D
L
E
V
-----
L
Q
L
I
S
E
P
A
A
A
V
L
A
Y
D
A
-----------------
S
D
K
---
I
I
V
V
A
D
L
G
G
S
R
S
D
V
T
V
L
A
S
R
S
----
G
M
Y
T
I
L
A
-
T
V
H
D
Y
E
Y
H
G
I
A
L
D
K
V
L
I
D
H
F
S
K
E
F
L
K
--
K
N
P
G
A
K
D
P
R
E
N
P
R
S
L
A
K
L
R
L
E
A
E
S
T
K
R
A
L
S
--
R
S
----
T
N
A
S
-----
F
S
V
E
SL
I
------
D
G
-
L
D
F
A
S
T
I
N
R
L
R
Y
E
T
I
A
R
T
V
F
E
G
F
N
R
L
V
E
S
A
V
K
K
A
G
L
D
P
L
D
V
D
E
V
I
M
S
G
G
T
S
N
T
P
R
I
A
A
N
F
--
R
--
Y
I
F
P
-
E
-
S
T
R
ILAPSTDP
S
A
L
N
P
S
E
L
Q
A
R
G
A
A
L
Q
A
S
L
I
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
80.06
20%
-85
* C3 *
4FL9
3
HSP7C_BOVIN
A:
[4-393]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
-
H
G-
K
V
E
I
I
A
N
DQG-
N
----------
R
T
-------
T
P
S
Y
--
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
--------------
R
F
D
----------------------
D
--------------------------
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
--
K
G
---
E
T
-----
K
S
F
---
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
--
Y
L
G
K
T
V
T
N
-------
A
V
-------
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
-
A
G
L
N
V
-----
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-----
K
--
V
-----
G
A
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
----
G
I
F
E
V
K
S
-
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
--
K
H
K
K
D
I
S
--
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
----
T
Q
A
S
-----
I
E
I
D
--
S
LY----
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
--
Q
--
D
F
F
N
G
K
-
E
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
79.78
20%
-88
- C3 -
3I33
3
HSP72_HUMAN
A:
[23-402]
-
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
-
H
G-
K
V
E
I
I
A
N
DQG-
N
----------
R
T
-------
T
P
S
Y
--
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
--------------
K
F
E
D
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
--------------------------
V
Q
V
E
Y
------------------------
K
G
---
E
T
-----
K
T
F
---
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
--
G
K
V
H
S
-------
A
V
-------
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
-
T
G
L
N
V
-----
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-----
K
GC
A
-----
G
G
E
K
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
----
G
I
F
E
V
K
S
-
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
--
K
H
K
K
D
I
G
--
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
----
T
Q
A
S
-----
I
E
I
D
--
S
LY----
E
G
-
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
--
Q
--
D
F
F
N
G
K
-
E
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
79.48
20%
-84
- C3 -
4J8F
14
F10A1_RAT (first)
A:
[11-389]
-
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
-
H
--
G
KVEIIANDQG
N
----------
R
T
-------
T
P
S
Y
--
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
--------------
K
F
G
----------------------
D
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
----------------------------
K
G
---
E
T
-----
K
A
F
---
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
--
Y
P
V
T
N
-------
A
V
-------
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
-
A
G
L
N
V
-----
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-----
T
--
G
-----
K
G
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
-
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
--
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
----
T
Q
A
S
-----
L
E
I
D
--
S
LF----
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
--
Q
--
D
F
F
N
-
G
R
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
79.18
21%
-85
- C3 -
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
-
N
--
G
----------
K
T
E
I
L
A
N
EQGN
R
I
-------
T
P
S
Y
--
V
A
F
T
D
D
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
--------------
K
Y
N
D
R
S
V
Q
K
D
I
K
H
LP
F
N
--------
V
V
N
K
DG
K
P
A
V
E
V
S
--------------
V
----------------------------
K
G
---
E
K
-----
K
V
F
---
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
--
T
K
V
T
H
-------
A
V
-------
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
-
A
G
L
N
V
-----
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-----
S
--------
D
K
E
H
---
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
E
N
----
G
V
F
E
V
Q
A
-
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
--
K
H
G
I
D
V
S
--
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
--
S
Q
----
M
S
T
R
-----
I
E
I
D
--
S
FV----
D
G
-
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
--
E
--
S
Y
F
D
G
K
-
K
A
S
--------
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
78.30
21%
-80
- C3 -
5E84
7
GRP78_HUMAN
A:
[5-384]
-
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
-
N
G-
R
V---------
E
IIANDQGN--
R
I
-------
T
P
S
Y
--
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
--------------
T
W
N
D
P
S
V
Q
Q
D
I
K
F
LP
F
K
--------
V
V
E
K
KT
K
P
Y
I
Q
----------------
V
----------------------------
D
I
GGG
Q
T
-----
K
T
F
---
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
--
K
K
V
T
H
-------
A
V
-------
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
-
A
G
L
N
V
-----
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-----
R
--------
E
G
E
K
---
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
D
N
----
G
V
F
E
V
V
A
-
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
--
K
T
G
K
D
V
R
K
--
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
--
S
Q
----
H
Q
A
R
-----
I
E
I
E
--
S
FY----
E
G
-
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
--
K
--
E
F
F
N
G
K
-
E
P
S
--------
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.25
24%
-110
- C3 -
1DKG
-
DNAK_ECOLI
D:
[136-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
-------
A
V
-------
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
------
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
----
Y
-----
G
--
L
-----
D
K
-
T
GNR
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
----
E
K
T
F
E
-
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
--
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
--
R
L
K
E
A
A
E
K
A
K
I
E
L
S
--
S
A
----
Q
Q
T
D
VNLPY
I
T
A
D
--
A
------
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
--
A
E-
F
F
G
K
-
E
-
P
R
K
--------
D
V
N
-
P
D
E
A
V
A
I
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.90
24%
-102
- C3 -
2KHO
-
DNAK_ECOLI
A:
[136-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
-------
A
V
-------
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
-----
G
R
I
A
G
L
E
-
V
K
R
I
I
N
E
P
T
A
A
A
L
A
----
Y
-----
G
--
L
-----
D
K
G
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
-
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
--
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
--
R
L
K
E
A
A
E
K
A
K
I
E
L
S
--
S
A
----
Q
Q
T
D
VNLPY
I
T
A
D
--
A
------
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
--
A
E
-
F
F
G
K
-
E
-
P
R
K
--------
D
V
N
-
P
D
E
A
V
A
I
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.12
23%
-98
- C3 -
5E84
6
GRP78_HUMAN
A:
[120-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
A
M
V
L
T
K
M
K
--
E
--
T
A
E
A
Y
-------
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
-----
G
T
I
A
G
L
N
-
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-----
R
--
E
-----
G
E
K
N
---
I
L
-
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
D
N
G
V
----
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
----
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
--
S
Q
H
Q
A
R
I
E
I
E
-----
S
F
Y
E
----------
G
-
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
--
K
E
F
F
N
G
K
-
E
-
P
S
---------
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.75
23%
-90
- C3 -
1HJO
2
HS71A_HUMAN
A:
[115-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
S
M
V
L
T
K
M
K
--
E
--
I
A
E
A
Y
-------
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-----
G
V
I
A
G
L
N
-
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-----
T
--
G
-----
K
G
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
D
D
G
----
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
Q
N
K
R
A
--
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
----
A
S
L
E
-----
I
D
S
L
--
F
------
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
--
Q
D
-
F
F
N
G
-
R
-
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.42
23%
-89
- C3 -
2E88
1
HS71A_HUMAN
A:
[120-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
S
M
V
L
T
K
M
K
--
E
--
I
A
E
A
Y
-------
L
G
YPVT
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-----
G
V
I
A
G
L
N
-
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-----
T
--
G
-----
K
G
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
D
D
G
----
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
Q
N
K
R
A
--
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
----
A
S
L
E
-----
I
D
S
L
--
F
------
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
--
Q
D
-
F
F
N
G
-
R
-
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.33
23%
-89
- C3 -
3ATU
3
HS71A_HUMAN
A:
[121-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
S
M
V
L
T
K
M
K
--
E
--
I
A
E
A
Y
-------
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-----
G
V
I
A
G
L
N
-
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-----
T
--
G
-----
K
G
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
D
D
G
----
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
Q
N
K
R
A
--
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
----
A
S
L
E
-----
I
D
S
L
--
F
------
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
--
Q
D
-
F
F
N
G
-
R
-
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.30
23%
-90
- C3 -
3AY9
4
HS71A_HUMAN
A:
[121-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
S
M
V
L
T
K
M
K
--
E
--
I
A
E
A
Y
-------
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-----
G
V
I
A
G
L
N
-
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-----
T
--
G
-----
K
G
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
D
D
G
----
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
Q
N
K
R
A
--
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
----
A
S
L
E
-----
I
D
S
L
--
F
------
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
--
Q
D
-
F
F
N
G
-
R
-
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.93
23%
-91
- C3 -
1S3X
4
HS71A_HUMAN
A:
[117-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
S
M
V
L
T
K
M
K
--
E
--
I
A
E
A
Y
-------
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-----
G
V
I
A
G
L
N
-
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
-----
T
--
G
-----
K
G
E
R
---
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
D
D
G
----
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
Q
N
K
R
A
--
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
----
A
S
L
E
-----
I
D
S
L
--
F
------
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
--
Q
D
-
F
F
N
G
-
R
-
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.92
24%
-90
- C3 -
3GDQ
3
HS71L_HUMAN
A:
[141-401]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
S
S
M
V
L
T
K
L
K
--
E
--
T
A
E
A
F
-------
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-----
G
V
I
A
G
L
N
-
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
-----
G
----------
E
R
---
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
D
D
G
----
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
E
E
F
K
R
--
K
H
K
K
D
I
S
Q
N
K
R
A
--
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
----
A
N
L
E
-----
I
D
S
L
--
Y
------
E
G
-
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
M
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
-
Q
R
L
L
Q
D
--
Y
F
N
G
-
R
-
D
L
N
--------
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------