@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0409: (2016-04-22 )
MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVADHAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSALAPLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRRYGFHGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLEGLVMGTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIETGDRSAQLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLGIALDQDRNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA
Atome Classification :
(35 SA)
.........10........20........30......-----------------..----40-----------.-----------..----......50.-.......60-.--.----..--.....70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260-.--.-.....270.......280.......290.......300.......310.......320.......330.......340....-...350........360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
S
T
V
L
V
INSGSS
S
L
K
F
Q
L
VEPVA
G
M
S
R
A
A
G
I
V
E
R
IG-----------------ER----S------------S-----------P
V
----
A
D
H
A
Q
A
L
H
R
-
A
F
K
M
L
A
ED--G--I----D
L
--
Q
T
C
G
L
V
A
V
G
H
R
VVHGGTEFHQPTLL
D
D
T
V
I
G
K
L
E
E
L
S
A
LAPLHNP
P
A
V
L
G
I
K
V
A
R
R
L
L
A
N
V
A
H
V
A
V
F
D
T
A
F
FHDLPP
A
A
A
T
Y
A
I
D
R
D
V
A
D
R
W
H
I
R
R
YGFHGT
S
H
Q
Y
V
S
E
R
A
A
A
F
LGRPL
D
G
L
N
Q
I
V
L
HLGNGA
S
A
S
A
IARGRPVETSMGLT
P
L
E
G
L
V
MGTRSGDLD
P
G
V
I
S
Y
L
W
R
T
A
RM
G
V
E
D
I
E
S
M
L
N
HRSGMLGLA-G--E-RD
F
R
R
L
R
L
V
I
ETGDR
S
A
Q
L
A
Y
E
V
F
I
H
R
L
R
K
Y
L
G
A
Y
L
A
V
LGHT
D
V
V
S
F
TAGIGEN
D
A
A
V
R
R
D
A
L
AGLQGL
G
I
A
LDQDRNLGPG-HGAR-RISSDDS
P
I
A
V
L
V
VPTN
E
E
L
A
I
A
R
D
C
L
R
V
LGGRRA
3
PsiBlast_PDB
98.00
77%
-125
- C6 -
4IZ9
7
ACKA_MYCA1
A:
[15-392]
----
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
G
-----------------
E
------------------
S
-----------
P
V
----
P
D
H
D
A
A
L
R
R
-
A
F
D
M
L
A
G
D
--
G
--
V
----
D
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
P
G
A
-
K
G
A
R
-
Q
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
---
42
HHSearch
97.31
77%
-122
- C6 -
3R9P
3
ACKA_MYCPA
A:
[12-390]
--
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
-----------------
E
E
----
S
------------
S
-----------
P
V
----
P
D
H
D
A
A
L
R
R
-
A
F
D
M
L
A
G
D
--
G
--
V
----
D
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
V
----
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
G
-
K
G
A
R
-
Q
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
----
4
PsiBlast_PDB
97.09
77%
-121
- C6 -
3R9P
3
ACKA_MYCPA
A:
[14-391]
----
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
-----------------
E
E
----
S
------------
S
-----------
P
V
----
P
D
H
D
A
A
L
R
R
-
A
F
D
M
L
A
G
D
--
G
--
V
----
D
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
G
-
K
G
A
R
-
Q
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
---
21
PsiBlast_CBE
96.76
77%
-121
- C6 -
3R9P
1
ACKA_MYCPA
B:
[14-391]
----
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
-----------------
E
------------------
S
-----------
P
V
----
P
D
H
D
A
A
L
R
R
-
A
F
D
M
L
A
G
D
--
G
--
V
----
D
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
G
-
K
G
A
R
-
Q
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
---
2
PsiBlast_PDB
96.68
77%
-126
- C6 -
3P4I
1
ACKA_MYCA1
A:
[15-392]
----
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
-------------------
E
----
S
------------
S
-----------
P
V
----
P
D
H
D
A
A
L
R
R
-
A
F
D
M
L
A
G
D
--
G
--
V
----
D
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
P
G
A
-
K
G
A
R
-
Q
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
---
1
PsiBlast_PDB
94.48
78%
-123
- C6 -
4DQ8
-
ACKA_MYCMM
A:
[9-385]
---
V
V
L
V
L
N
S
G
S
S
S
L
K
F
Q
L
V
E
P
D
S
G
M
S
R
A
T
G
N
I
E
R
I
-------------------------------------------------------
P
D
H
D
A
A
L
R
R
-
V
F
E
I
L
A
E
D
--
D
--
I
----
D
L
--
Q
S
C
G
L
V
A
V
G
H
R
V
V
H
G
G
K
D
F
Y
E
P
T
L
L
N
D
A
V
I
G
K
L
D
E
L
S
P
L
A
P
L
H
N
P
P
A
V
L
C
I
R
V
A
R
A
L
L
P
D
V
P
H
I
A
V
F
D
T
A
F
F
H
Q
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
V
W
K
I
R
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
E
F
L
G
K
P
I
G
D
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
R
P
V
E
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
G
V
I
G
Y
L
W
R
T
A
K
L
G
V
D
E
I
E
S
M
L
N
H
R
S
G
M
L
G
L
A
-
G
--
E
-
R
D
F
R
R
L
R
A
M
I
D
D
G
D
P
A
A
E
L
A
Y
D
V
F
I
H
R
L
R
K
Y
V
G
A
Y
L
A
V
L
G
H
T
D
V
V
S
F
T
A
G
I
G
E
H
D
A
A
V
R
R
D
T
L
A
G
M
A
E
L
G
I
S
L
D
E
R
R
N
A
C
P
S
-
G
G
A
R
-
R
I
S
A
D
D
S
P
V
T
V
L
V
I
P
T
N
E
E
L
A
I
A
R
H
C
C
S
V
L
-----
46
HHSearch
91.11
66%
-118
- C6 -
4IJN
4
ACKA_MYCS2
A:
[22-397]
-
M
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
-----------------
S
G
-----------------------------
A
V
----
P
D
H
D
A
A
L
R
A
-
A
F
D
E
L
A
A
A
--
G
--
L
----
H
L
--
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
A
----
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
S
-
D
E
P
R
-
L
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
------
5
PsiBlast_PDB
90.94
66%
-118
- C6 -
4IJN
4
ACKA_MYCS2
A:
[24-397]
---
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
-----------------------
S
------------
G
-----------
A
V
----
P
D
H
D
A
A
L
R
A
-
A
F
D
E
L
A
A
A
--
G
--
L
----
H
L
--
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
-
G
--
A
-
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
S
-
D
E
P
R
-
L
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
------
22
PsiBlast_CBE
90.18
66%
-116
- C6 -
4IJN
3
ACKA_MYCS2
B:
[24-397]
---
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
-----------------------
S
------------
G
-----------
A
V
----
P
D
H
D
A
A
L
R
A
-
A
F
D
E
L
A
A
A
--
G
--
L
----
H
L
--
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
-
G
--
A
-
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
S
-
D
E
P
R
-
L
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
------
7
PsiBlast_PDB
85.54
43%
-109
- C6 -
1TUY
2
ACKA_METTE
A:
[3-396]
----
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDN
S
I
I
T
Q
K
K
FDG
K
K
L
-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
EF
G
--
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
-
Q
E
I
--
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
-----
24
PsiBlast_CBE
84.74
43%
-108
- C6 -
1TUU
3
ACKA_METTE
B:
[3-396]
----
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDNSIITQKKFDGKKL-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
EF
G
--
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
-
Q
E
I
--
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
-----
25
PsiBlast_CBE
84.73
43%
-110
- C6 -
1G99
2
ACKA_METTE
B:
[3-396]
----
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDNSIITQKKFDGKKL-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
EF
G
--
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
-
Q
E
I
--
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
-----
38
HHSearch
84.54
44%
-104
- C6 -
1G99
2
ACKA_METTE
A:
[1-398]
--
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
-----------------
I
D
N
S
I
I
T
Q
K
K
FDG
K
K
L
E
K
L
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
--
E
FG
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
--
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
--
G
Q
E
I
-
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
---
6
PsiBlast_PDB
84.13
43%
-105
- C6 -
1TUU
2
ACKA_METTE
A:
[3-396]
----
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDN
S
I
I
T
Q
K
K
FDG
K
K
L
-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
EF
G
--
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
-
Q
E
I
--
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
-----
23
PsiBlast_CBE
84.02
43%
-108
- C6 -
1TUY
3
ACKA_METTE
B:
[3-396]
----
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDNSIITQKKFDGKKL-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
EF
G
--
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
-
Q
E
I
--
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
-----
45
HHSearch
83.86
46%
-107
* C6 *
2IIR
-
ACKA_THEMA
A:
[1-400]
--
M
R
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
G
I
A
E
R
I
G
-----------------
I
E
G
S
R
L
V
------------
H
R
VGD
E
K
H
V
I
E
R
E
L
----
P
D
H
E
E
A
L
K
L
-
I
L
N
T
L
V
D
E
--
K
LG
V
----
I
K
--
D
L
K
E
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
I
P
F
F
I
M
E
K
E
G
I
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
K
G
F-
S
-
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
I
R
G
K
E
G
-
I
I
S
T
P
D
S
R
V
K
V
L
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
V
E
K
---
9
PsiBlast_PDB
83.86
45%
-110
- C6 -
2IIR
-
ACKA_THEMA
A:
[3-398]
----
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
G
I
A
E
R
I
G
IEG
S
R
L
V
H
R
VGD
E
K
H
V
I
E
R
----
E
------------
L
-----------
P
------
D
H
E
E
A
L
K
L
-
I
L
N
T
L
V
D
E
--
K
--
L
GVIK
D
L
--
K
E
--
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
I
P
F
F
I
M
E
K
E
G
I
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
-
K
GF
S
-
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
I
-
R
G
K
E
G
I
I
S
T
P
D
S
R
V
K
V
L
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
V
-----
8
PsiBlast_PDB
83.82
43%
-104
- C6 -
1G99
2
ACKA_METTE
A:
[3-396]
----
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDN
S
I
I
T
Q
K
K
FDG
K
K
L
-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
EF
G
--
V
----
I
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
-
Q
E
I
--
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
-----
58
Fugue
83.70
44%
-104
- C6 -
1G99
2
ACKA_METTE
A:
[1-398]
--
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
IDN
S
I
I
T
Q
K
K
FDG
K
K
L
-
E
K
----
L
------------
T
-----------
D
L
----
P
T
H
K
D
A
L
E
E
-
V
V
K
A
L
T
D
D
--
E
--
F
----
G
V
IK
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
-
G
--
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
G
--
Q
E
I
-
D
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
---
34
PsiBlast_CBE
81.03
39%
-101
- C6 -
4XH1
4
TDCD_SALTY
A:
[21-411]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
------------------
T
E
----
N
------------
A
F
L
S
I
NG
D
K
---
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
32
PsiBlast_CBE
80.71
39%
-101
- C6 -
4FWP
3
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
36
PsiBlast_CBE
80.61
39%
-98
- C6 -
4FWL
2
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
N---
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
15
PsiBlast_PDB
80.48
39%
-99
- C6 -
1X3N
2
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
17
PsiBlast_PDB
80.33
39%
-100
- C6 -
2E1Z
2
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
13
PsiBlast_PDB
80.07
39%
-99
- C6 -
4XH4
4
TDCD_SALTY
A:
[21-411]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
N
GD
K
---
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
V
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
29
PsiBlast_CBE
80.05
39%
-100
- C6 -
4FWS
5
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NG
D
K
---
P
I
N
LAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
40
HHSearch
80.03
39%
-98
- C6 -
4XH4
4
TDCD_SALTY
A:
[18-411]
-
F
P
V
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
A
F
L
S
I
N
GD
K
P
I
N
L
-----------
A
H
----
S
N
Y
E
D
A
L
K
A
-
I
A
F
E
L
E
K
R
--
D
-----------
L
T
D
S
V
A
L
I
G
H
R
I
V
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
--
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
-
19
PsiBlast_PDB
79.94
39%
-100
- C6 -
4FWK
2
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
33
PsiBlast_CBE
79.82
39%
-100
- C6 -
4FWO
4
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
14
PsiBlast_PDB
79.79
39%
-100
- C6 -
1X3M
1
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
31
PsiBlast_CBE
79.56
39%
-98
- C6 -
4FWQ
3
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NG
D
K
---
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
18
PsiBlast_PDB
79.52
39%
-100
- C6 -
2E20
2
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
30
PsiBlast_CBE
79.25
39%
-95
- C6 -
4FWR
3
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
35
PsiBlast_CBE
79.03
39%
-99
- C6 -
4FWM
4
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A
20
PsiBlast_PDB
78.87
39%
-98
- C6 -
4FWN
3
TDCD_SALTY
A:
[20-410]
----
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
-----------------
T
E
----
N
------------
A
F
L
S
I
NGDK---
P
I
NLAH
S
N
Y
E
D
A
L
K
A
I
A
F
E
L
E
K
R
D
--
L
--
T
----
D
------
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
-
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
N
S
H
G
E
R
-
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
-
L
G
N
V
K
A