@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1348: (2016-04-30 )
MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQDAEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTVKPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQHDDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLRDEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTGLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR
Atome Classification :
(62 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------......-...10........20........30........40........50.......----.60........70........80.....-...90........100----.......110-----------.......120.......130.....----..140.......150-----.......160.......170......-----------------------------.180.....---------------------..190.......200.......210...------....220.......230...-....240.......250.......260.......270......--.280.......290.......300.......310.......320.....--.---.---330.......340---........350.......360.......370.......380....--...390.......400.....--..410.-......420..-.....430.....--..440---...--.....450....--...460.......470.......480.......490...--....500.......510-----..-.....520.--.--.....530.--.....----.540.......550.....--..560.......570------........580.......590......-----.---600.-------..-----....610.......--620-.--......-.630.......640.......650.......660.---......670...-.--...680.......690....-...700..--...---..-710-...-......720-..-------.....730......-.740.-.-.-..-...750.......760.......770.......780.......790-.--.----.-----.....800.......-810.......820.......830.--.--.....840.......850.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARG
L
Q
-
G
V
M
L
R
SFGARDH
T
A
T
V
I
E
T
ISIA
P
H
F
V
R
V
R
MVS
P
T
LFQDAEAEP
A
A
W
L
R
F
W
F
----PDPNGSNT
E
F
Q
R
A
Y
T
ISEADPAAG
R
F
A
V
-
D
V
V
L
HDPAGP
A
S
S
W
AR----TVKPG
A
T
I
A
V
-----------
M
S
L
MGSSRFDVPEEQPA
G
Y
L
L
IGDS----ASIPGM
N
G
I
I
E
TVPN-----DV
P
I
E
M
Y
L
E
QHDDND
T
L
I
PLAKHP
R
L
-----------------------------
R
V
R
W
V
MRR
D
---------------------
E
K
S
L
A
E
A
I
ENRDWSD
W
Y
AWATP
E
A
A
A
L
K
------
C
V
R
V
R
L
R
D
EFGF
P
K
S
E
I
H
A
Q
-
A
YWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARG
S
W
R
--
A
Q
A
A
S
R
L
L
A
P
L
K
L
P
L
V
L
S
G
V
L
A
A
L
V
T
L
A
Q
L
A
P
F
V
L
L
V
E
L
S
R
L
L
V
SGAGA--
H
---
R
---
L
F
T
V
G
F
A
A
V
G
L
L----G
T
G
A
L
L
A
A
A
L
T
L
W
L
H
V
I
D
A
R
F
A
R
A
L
R
L
R
L
L
S
K
L
S
RLP
L
G
W
F
TSRG--SGSI
K
K
LVTD
D
T
L
A
L
H
Y
L
V
T
H--A
V
P
D
A
V
-
A
A
V
V
A
P
V
G
V
L
V
-
Y
L
F
V
V
D
W
R
V
A
L
V
L--FG
P
V
----
L
V
Y
--
L
T
IT
S
S
L
T
IQSG--
P
R
I
V
Q
A
Q
R
W
A
E
KMNGEAGSYLEGQ
P
V
I
R
V
FGAA
S
S
S
F
R
R
--
R
L
D
E
Y
I
G
F
L
V
A
WQRPLA-----G
K
-
K
T
L
M
D
LATR--P--
A
T
F
L
W
L
I
AA--T
G
T
L
L
----
V
A
THRMDP
V
N
L
L
P
F
M
F
L
G
T
--
T
F
G
A
R
L
L
G
I
A
Y
G
L
G
-------
G
L
R
T
G
L
L
A
A
R
H
L
Q
V
T
L
D
E
T
E
L
A
V
R
EHP-----R---EPLD-------GE-----A
P
A
T
V
V
F
DHVTFGY--RP--G--V
P
V
I
Q
D
-
V
S
L
T
LRP
G
T
V
T
A
L
VGPSGS
G
K
S
T
L
A
T
L
L
A
R
F
H
DVE---RG
A
I
RV
G
G
Q
D
I
R
-
S
--
L
A
A
D
E
L
Y
T
R
V
G
F
V
L
Q
E
A
Q
LV-HGTAAE
N
I
--
A
L
A---VP-D---A
P
A
-
E
Q
V
Q
V
A
A
R
E
-
A
Q
-------
I
H
D
R
V
LRLPDGY
D
T
-
V
LG-A-N-S-GL-SGGERQ
R
L
T
I
A
R
A
I
LGDT
P
V
L
I
L
DEATAFADP
E
S
E
Y
L
V
Q
Q
A
L
N
R
L--T--R----D-----
R
T
V
L
V
I
A
H
R
L
H
T
ITR-A
D
Q
I
V
V
LDHG
R
I
VERG
T
H
E
E
L
L
AA--G--G
R
Y
C
R
L
W
DTGQG
S
R
V
A
V
A
AAQDGTR
104
HHSearch
83.30
28%
-117
- C3 -
4Q4H
-
Y288_THEMA
B:
[29-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
F
--
D
---
L
---
L
P
R
Y
M
L
I
L
G
T
I
Y
----
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
--
S
I
I
Q
F
F
-
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
----
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
--
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
-
K
E
M
E
--
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
-----
I
F
-
S
G
V
L
P
P
L
M
N
--
M
V
N
N
L
G
F
A
L
I
S
G
--
F
G
G
W
L
----
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
--
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
-------
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
----------
V
E
L
-------
R
E
-----
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
--
K
--
K
P
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
-
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
--
K
Y
G
---
N
P
-
G
---
A
T
D
-
E
E
I
K
E
A
A
K
L
-
T
H
-------
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
-
V
L
T
-
D
N
G
-
E
-
D
L
-
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
----
G
-----
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------
11
PsiBlast_PDB
76.64
34%
-105
- C3 -
4AYX
7
ABCBA_HUMAN
A:
[64-574]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
L
G
L
S
A
V
F
L
C
----
G
A
A
A
--
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
--
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
-
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
--
G
R
Y
L
R
K
L
T
K
V
T
Q
--
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
-------
V
R
A
F
G
K
E
M
T
E
I
E
K
--
Y
A
S
K
-
V
D
H
V
M
Q
L
A
R
K
E
A
-----
F
A
-
R
A
G
F
F
G
A
T
G
--
L
--
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
----
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
--
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
-------
E
L
M
K
G
L
G
A
G
G
R
L
W
------
E
L
L
E
R
E
-
P
-----
K
---
L
P
F
N
E
G
V
I
L
N
E
K
S
-----
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
--
E
--
V
P
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
-
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
--
A
Y
G
---
A
D
-
D
PSS
V
T
A
-
E
E
I
Q
R
V
A
E
V
-
A
N
-------
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
-
V
V
G
-
E
-
K
-
G
-
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
----
G
-----
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-
N
--
G
------------------------
106
HHSearch
76.10
29%
-108
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[10-572]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
V
--
D
Y
S
D
N
---
L
T
R
L
C
L
G
L
S
A
V
F
----
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
--
N
L
S
D
G
L
-
R
A
G
A
Q
A
S
V
G
I
S
-
M
M
F
F
V
S
P
N
L
A
T
F
V
--
L
S
V
V
----
P
P
V
--
S
I
I
A
V
I
Y
G
R
Y
L
R
--
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
-
E
I
E
--
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
-----
F
A
-
R
A
G
F
F
G
A
T
G
--
L
S
G
N
L
I
V
L
S
V
L
Y
--
K
G
G
L
L
----
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
--
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
-------
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-----
V
---
I
L
N
E
-------
K
S
-----
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
A
RP
E
--
V
P
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
-
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
--
A
Y
G
---
A
D
-
D
PSS
V
T
A
-
E
E
I
Q
R
V
A
E
V
-
A
N
-------
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
-
V
V
G
-
E
K
G
-
V
-
L
L
-
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
----
G
-----
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-----------------------------
5
PsiBlast_PDB
75.36
31%
-105
- C3 -
3QF4
1
Y288_THEMA
B:
[112-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
--
S
I
I
Q
F
F
-
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
----
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
--
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
-----
G
V
L
P
P
L
M
N
M
V
N
N
--
L
--
G
--
F
A
L
I
S
G
--
F
G
G
W
L
----
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
--
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
-------
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
-----
D
---
A
V
E
L
-------
R
E
-----
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
--
K
--
K
P
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
-
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
--
K
Y
G
---
N
P
-
G
---
A
T
D
-
E
E
I
K
E
A
A
K
L
-
T
H
-------
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
-
V
L
T
-
D
-
N
G
E
-
D
L
-
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
----
G
-----
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------
6
PsiBlast_PDB
75.35
31%
-105
- C3 -
4Q4A
1
Y288_THEMA
B:
[112-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
--
S
I
I
Q
F
F
-
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
----
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
--
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
-----
G
V
L
P
P
L
M
N
M
V
N
N
--
L
--
G
--
F
A
L
I
S
G
--
F
G
G
W
L
----
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
--
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
-------
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
-----
D
---
A
V
E
L
-------
R
E
-----
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
--
K
--
K
P
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
-
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
--
K
Y
G
---
N
P
-
G
---
A
T
D
-
E
E
I
K
E
A
A
K
L
-
T
H
-------
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
-
V
L
T
-
D
-
N
G
E
-
D
L
-
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
----
G
-----
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------
109
HHSearch
75.22
25%
-110
- C3 -
4Q4H
-
?
A:
[4-569]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
F
--
S
---
L
---
V
L
K
T
G
I
L
M
L
I
V
A
----
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
--
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
--
L
L
R
I
V
V
-
R
A
P
L
L
F
V
G
G
I
V
-
M
A
V
S
I
N
V
K
L
S
S
V
L
--
I
F
L
I
----
P
P
I
--
V
L
L
F
V
W
L
T
K
K
G
N
--
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
-
Y
E
N
E
--
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
-----
S
L
-
I
V
F
A
L
P
L
F
I
F
I
V
--
N
M
G
M
I
A
V
L
W
--
F
G
G
V
L
----
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
--
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
-------
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
-----
A
----
L
A
L
-------
P
N
-----
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
--
F
E
N-
T
--
D
P
V
L
S
G
-
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
-
T
--
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
-
S
G
T
I
K
E
N
L
--
K
W
G
---
R
E
-
D
---
A
T
D
-
D
E
I
V
E
A
A
K
I
-
A
Q
-------
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
-
R
V
E
-
R
G
G
-
R
-
N
F
-
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
--
T
--
K
----
G
-----
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
--
K
P
Y
R
E
I
Y
E
S
Q
F
--------------
7
PsiBlast_PDB
75.02
31%
-101
- C3 -
4Q4H
-
Y288_THEMA
B:
[112-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
--
S
I
I
Q
F
F
-
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
----
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
--
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
-----
G
V
L
P
P
L
M
N
M
V
N
N
--
L
--
G
--
F
A
L
I
S
G
--
F
G
G
W
L
----
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
--
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
-------
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
-----
D
---
A
V
E
L
-------
R
E
-----
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
--
K
--
K
P
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
-
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
--
K
Y
G
---
N
P
-
G
---
A
T
D
-
E
E
I
K
E
A
A
K
L
-
T
H
-------
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
-
V
L
T
-
D
-
N
G
E
-
D
L
-
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
----
G
-----
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------
8
PsiBlast_PDB
74.92
31%
-100
- C3 -
4Q4J
-
Y288_THEMA
B:
[112-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
--
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
--
S
I
I
Q
F
F
-
S
G
I
V
T
L
A
G
A
V
I
-
M
M
F
R
V
N
V
I
L
S
L
V
T
--
L
S
I
V
----
P
L
T
--
V
L
I
T
Q
I
V
S
S
Q
T
R
--
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
-----
G
V
L
P
P
L
M
N
M
V
N
N
--
L
--
G
--
F
A
L
I
S
G
--
F
G
G
W
L
----
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
--
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
-------
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
-----
D
---
A
V
E
L
-------
R
E
-----
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
--
K
--
K
P
V
L
K
D
-
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
-
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
-
S
T
T
V
K
E
N
L
--
K
Y
G
---
N
P
-
G
---
A
T
D
-
E
E
I
K
E
A
A
K
L
-
T
H
-------
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
-
V
L
T
-
D
-
N
G
E
-
D
L
-
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
----
G
-----
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
--
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------
10
PsiBlast_PDB
74.63
34%
-103
- C3 -
4AYT
8
ABCBA_HUMAN
A:
[64-567]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
L
G
L
S
A
V
F
L
C
----
G
A
A
A
--
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
--
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
-
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
--
G
R
Y
L
R
K
L
T
K
V
T
Q
--
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
-------
V
R
A
F
G
K
E
M
T
E
I
E
K
--
Y
A
S
K
-
V
D
H
V
M
Q
L
A
R
K
E
A
-----
F
A
-
R
A
G
F
F
G
A
T
G
--
L
--
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
----
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
--
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
-------
E
L
M
K
G
L
G
A
G
G
R
L
W
------
E
L
L
E
R
E
-
P
-----
K
---
L
P
F
N
E
G
V
I
L
N
E
K
S
-----
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
--
E
--
V
P
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
-
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
--
A
Y
G
---
A
D
-
D
PSS
V
T
A
-
E
E
I
Q
R
V
A
E
V
-
A
N
-------
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
-
V
V
G
-
E
-
K
-
G
-
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
----
G
-----
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------------
12
PsiBlast_PDB
74.61
34%
-102
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[64-572]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
L
G
L
S
A
V
F
L
C
----
G
A
A
A
--
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
--
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
-
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
--
G
R
Y
L
R
K
L
T
K
V
T
Q
--
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
-------
V
R
A
F
G
K
E
M
T
E
I
E
K
--
Y
A
S
K
-
V
D
H
V
M
Q
L
A
R
K
E
A
-----
F
A
-
R
A
G
F
F
G
A
T
G
--
L
--
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
----
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
--
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
-------
E
L
M
K
G
L
G
A
G
G
R
L
W
------
E
L
L
E
R
E
-
P
-----
K
---
L
P
F
N
E
G
V
I
L
N
E
K
S
-----
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
--
E
--
V
P
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
-
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
--
A
Y
G
---
A
D
-
D
PSS
V
T
A
-
E
E
I
Q
R
V
A
E
V
-
A
N
-------
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
-
V
V
G
-
E
-
K
-
G
-
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
----
G
-----
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-----------------------------
112
HHSearch
74.33
28%
-110
- C3 -
3WMG
3
?
A:
[32-597]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
G
---
E
---
T
W
K
Y
S
V
G
F
V
G
I
G
----
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
--
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
--
L
-
G
A
V
L
-
F
N
L
A
Q
C
V
V
G
I
I
-
V
A
F
I
F
A
P
A
L
T
G
V
L
--
I
A
L
S
----
P
L
V
--
V
L
A
V
V
V
Q
M
I
E
M
S
--
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
-
E
T
Q
--
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
-----
I
S
-
D
G
L
F
F
G
L
S
M
--
L
V
I
F
C
V
Y
A
L
A
L
W
--
W
G
G
Q
L
----
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
--
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
-------
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
-----
G
A
E
V
V
T
Q
P
-------
L
V
-----
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
--
P
T
--
R
MN
V
E
V
L
R
G
-
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
-
N
--
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
--
L
Y
G
---
K
R
-
D
---
A
T
D
-
E
E
V
I
Q
A
L
R
E
-
A
N
-------
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
-
E
V
G
-
E
R
G
-
L
-
A
L
-
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
--
M
A
S
D
----
G
-----
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
--
G
F
Y
Y
Q
L
V
E
K
Q
L
A
-------------
103
HHSearch
73.98
25%
-115
- C3 -
4RY2
-
?
A:
[160-724]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
L
--
N
---
D
---
L
H
I
I
S
A
G
F
A
V
I
F
----
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
--
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
--
A
T
L
T
I
M
-
I
D
T
I
M
A
V
I
G
G
I
-
L
L
Y
I
Q
N
S
S
L
F
F
I
S
--
F
I
I
I
----
L
L
Y
--
G
I
I
V
T
V
F
N
K
P
I
Q
--
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
--
T
R
D
K
I
E
T
V
M
-
K
S
S
F
K
E
G
-----
M
L
-
Y
I
N
L
S
S
L
T
G
--
I
V
A
G
L
G
G
I
V
I
L
W
--
A
G
A
Y
N
----
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
--
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
-------
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
--------------------------------
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
L
--
R
--
K
P
V
L
K
N
-
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
-
N
--
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
-
S
G
T
V
K
E
N
L
--
C
L
G
---
N
E
-
N
---
V
D
M
-
D
E
I
I
K
A
A
K
M
-
A
N
-------
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
-
F
L
N
-
E
S
G
-
A
-
N
L
-
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
--
D
----
D
-----
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
--
G
C
Y
F
K
M
W
K
Q
T
E
N
T
------------
16
PsiBlast_PDB
72.65
33%
-104
- C3 -
4AYW
3
ABCBA_HUMAN
A:
[95-598]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
L
G
L
S
A
V
F
L
C
----
G
A
A
A
--
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
--
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
--
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
-
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
--
G
R
Y
L
R
K
L
T
K
V
T
Q
--
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
-------
V
R
A
F
G
K
E
M
T
E
I
E
K
--
Y
A
S
K
-
V
D
H
V
M
Q
L
A
R
K
E
A
-----
F
A
-
R
A
G
F
F
G
A
T
G
--
L
--
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
----
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
--
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
-------
E
L
M
K
G
L
G
A
G
G
R
L
W
------
E
L
L
E
R
E
-
P
-----
K
---
L
P
F
N
E
G
V
I
L
N
E
K
S
-----
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
P
--
E
--
V
P
I
F
Q
D
-
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
-
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
--
A
Y
G
---
A
D
-
D
PSS
V
T
A
-
E
E
I
Q
R
V
A
E
V
-
A
N
-------
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
-
V
V
G
-
E
-
K
-
G
-
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
----
G
-----
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------------
130
Fugue
72.48
23%
-103
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRK
P
V
I
D
S
S
S
K
A
G
R
K
D
M
K
I
K
------
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
R
P
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
SGCG
K
S
T
I
I
S
L
L
-
L
R
Y
Y
D
V
L
K
----
G
K
I
T
I
D
G
V
DVRD
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
I
T
R
E
E
M
V
A
A
C
K
M
A
NA
E
K
F
I
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
RNPK
I
L
L
L
D
EATSALDAES
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
NAD
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G
E
R
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
E
N
N
A
Q
K
TN
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
A
G
N
P
A
D
--
F
L
S
-
Q
---
G
H
F
W
A
L
M
F
L
V
L
A
----
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
D
S
P
Q
NA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
--
R
F
S
T
V
I
-
T
T
L
V
S
M
V
A
G
I
G
-
L
A
F
F
Y
G
W
Q
M
A
L
L
I
--
I
A
I
L
----
P
I
V
--
A
F
G
Q
Y
L
R
G
R
R
F
T
--
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
-
A
R
E
D
T
F
Y
E
--
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
-----
F
I
-
Q
G
L
S
Y
G
C
A
S
--
S
--
V
L
Y
L
L
N
T
C
A
--
Y
R
M
G
L
A
L
I
I
T
D
P
P
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
--
I
S
T
S
-
T
L
G
F
A
T
S
Y
F
-------
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
K
I
S
K
I
D
S
L
S
-----
L
---
A
G
E
K
-------
K
K
-----
L
Y
G
K
V
I
F
K
N
V
R
F
A
Y
PE
R
P
--
E
--
I
E
I
L
K
G
-
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
---
G
G
E
I
F
I
D
G
S
E
I
K
-
T
--
L
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
-
D
C
S
I
A
E
N
I
I
Y
G
L
D
---
P
S
-
S
---
V
T
M
-
A
Q
V
E
E
A
A
R
L
-
A
N
-------
I
H
N
F
I
A
E
L
P
E
G
F
E
T
-
R
V
G
-
D
-
R
G
T
-
Q
L
-
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
A
--
R
--
E
----
G
-----
R
T
C
I
V
I
A
H
R
L
N
T
V
M
N
-
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
---------------------------
59
PsiBlast_CBE
71.80
31%
-104
- C3 -
3WMG
3
?
A:
[71-591]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
V
G
F
V
G
I
G
V
F
----
E
F
--
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
--
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
-
A
Q
C
V
--
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
--
L
S
P
-----
L
V
V
--
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
--
K
L
D
P
L
--
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
-
S
M
L
V
I
F
C
V
Y
--
A
--
L
A
L
W
W
-------
G
G
Q
L
----
I
A
R
G
S
L
N
L
G
N
L
L
------
T
--
A
F
F
S
A
I
L
G
F
-
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T
---
Q
P
L
---------
V
-----
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
PT
R
M
--
N
--
V
E
V
L
R
G
-
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
-
N
--
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
-
S
G
T
I
R
D
N
I
--
L
Y
G
---
K
R
-
D
---
A
T
D
-
E
E
V
I
Q
A
L
R
E
-
A
N
-------
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
-
E
V
G
-
E
-
R
-
G
L
A
L
-
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
--
D
----
G
-----
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
--
G
PS
G
F
Y
Y
Q
L
-------------------
110
HHSearch
69.79
26%
-108
- C3 -
4MRS
12
ATM1_NOVAD
A:
[36-606]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
G
G
A
--
Q
---
P
---
A
L
T
V
A
L
A
F
V
L
A
Y
A
L
G
R
F
S
G
V
L
F
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
L
R
F
H
L
A
R
R
--
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
L
Y
F
--
L
L
F
N
I
A
-
P
T
V
I
E
L
T
A
-
V
I
-
V
I
F
W
L
N
F
G
L
G
L
V
T
--
A
T
I
L
----
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
--
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
-
R
E
E
A
--
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
-----
N
S
-
L
G
L
L
N
I
A
Q
A
--
L
I
V
N
L
L
M
A
G
A
M
A
--
W
T
V
Y
G
----
W
S
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
Y
L
T
--
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
-------
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
D
T
H
I
E
V
A
D
V
P
N
-----
A
----
P
A
L
-------
V
V
-----
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
--
D
R
--
D
--
R
E
I
L
H
G
-
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
-
H
--
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
-
N
D
T
I
G
Y
N
I
--
A
Y
G
---
R
D
-
G
---
A
S
R
-
A
E
V
D
A
A
A
K
G
-
A
A
-------
I
A
D
F
I
A
R
L
P
Q
G
Y
D
T
-
E
V
G
-
E
R
G
-
L
-
K
L
-
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
--
A
--
S
----
H
-----
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
-
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--
D
--
G
L
Y
A
E
M
W
A
R
Q
A
A
E
S
A
E
V
S
E
A
-----
22
PsiBlast_CBE
68.97
31%
-96
- C3 -
3B60
2
MSBA_SALTY
C:
[20-575]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
P
F
K
A
G
L
I
V
A
G
I
--
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
-
L
K
P
L
L
D
D
G
F
G
K
--
T
---
D
RSV
L
L
W
M
P
L
V
V
I
G
L
M
ILR-
G
I
T
S
Y
I
S
S
Y
C
I
S
W
---
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
--
A
L
I
T
V
V
-
R
E
G
A
S
I
I
G
L
F
I
-
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
VV
L
A
P
I
----
V
S
I
--
A
I
R
V
V
S
K
R
F
R
S
I
--
S
K
--
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
-
T
K
--
R
F
D
K
-----
V
S
N
K
M
R
L
Q
-----
G
M
-
K
-
M
V
S
A
S
S
I
--
S
--
D
P
I
I
Q
L
I
A
S
--
L
A
L
A
F
----
V
L
Y
A
A
S
F
P
-
S
V
M
D
S
L
T
A
G
T
IT
V
V
F
S
S
M
I
A
L
M
R
P
L
K
-------
S
L
-
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-----
Q
---
E
K
D
E
-------
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
---
P
--
G
RE
V
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
-
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
--
A
Y
A
R--
T
E
-
E
---
Y
S
R
-
E
Q
I
E
E
A
A
R
M
-
A
Y
-------
A
M
D
F
I
N
K
M
D
N
G
L
D
T
-
I
I
G
-
E
-
N
-
G
-
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
----
N
-----
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
-------------------
23
PsiBlast_CBE
68.87
31%
-96
- C3 -
3B60
2
MSBA_SALTY
B:
[20-575]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
P
F
K
A
G
L
I
V
A
G
I
--
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
-
L
K
P
L
L
D
D
G
F
G
K
--
T
---
D
RSV
L
L
W
M
P
L
V
V
I
G
L
M
ILR-
G
I
T
S
Y
I
S
S
Y
C
I
S
W
---
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
--
A
L
I
T
V
V
-
R
E
G
A
S
I
I
G
L
F
I
-
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
VV
L
A
P
I
----
V
S
I
--
A
I
R
V
V
S
K
R
F
R
S
I
--
S
K
--
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
-
T
K
--
R
F
D
K
-----
V
S
N
K
M
R
L
Q
-----
G
M
-
K
-
M
V
S
A
S
S
I
--
S
--
D
P
I
I
Q
L
I
A
S
--
L
A
L
A
F
----
V
L
Y
A
A
S
F
P
-
S
V
M
D
S
L
T
A
G
T
IT
V
V
F
S
S
M
I
A
L
M
R
P
L
K
-------
S
L
-
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-----
Q
---
E
K
D
E
-------
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
---
P
--
G
RE
V
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
-
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
--
A
Y
A
R--
T
E
-
E
---
Y
S
R
-
E
Q
I
E
E
A
A
R
M
-
A
Y
-------
A
M
D
F
I
N
K
M
D
N
G
L
D
T
-
I
I
G
-
E
-
N
-
G
-
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
----
N
-----
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
-------------------
4
PsiBlast_PDB
68.67
31%
-96
- C3 -
3B60
2
MSBA_SALTY
A:
[20-575]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
P
F
K
A
G
L
I
V
A
G
I
--
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
-
L
K
P
L
L
D
D
G
F
G
K
--
T
---
D
RSV
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
-
G
I
T
S
Y
I
S
S
Y
C
I
S
W
---
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
--
A
L
I
T
V
V
-
R
E
G
A
S
I
I
G
L
F
I
-
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
----
V
S
I
--
A
I
R
V
V
S
K
R
F
R
S
I
--
S
K
--
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
-
T
K
--
R
F
D
K
-----
V
S
N
K
M
R
L
Q
-----
G
M
-
K
-
M
V
S
A
S
S
I
--
S
--
D
P
I
I
Q
L
I
A
S
--
L
A
L
A
F
----
V
L
Y
A
A
S
F
P
-
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
-------
S
L
-
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-----
Q
---
E
K
D
E
-------
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
---
P
--
G
RE
V
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
-
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
--
A
Y
A
R--
T
E
-
E
---
Y
S
R
-
E
Q
I
E
E
A
A
R
M
-
A
Y
-------
A
M
D
F
I
N
K
M
D
N
G
L
D
T
-
I
I
G
-
E
-
N
-
G
-
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
----
N
-----
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
-------------------
21
PsiBlast_CBE
68.65
31%
-96
- C3 -
3B60
2
MSBA_SALTY
D:
[20-575]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
P
F
K
A
G
L
I
V
A
G
I
--
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
-
L
K
P
L
L
D
D
G
F
G
K
--
T
---
D
RSV
L
L
W
M
P
L
V
V
I
G
L
M
ILR-
G
I
T
S
Y
I
S
S
Y
C
I
S
W
---
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
--
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
--
A
L
I
T
V
V
-
R
E
G
A
S
I
I
G
L
F
I
-
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
VV
L
A
P
I
----
V
S
I
--
A
I
R
V
V
S
K
R
F
R
S
I
--
S
K
--
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
-
T
K
--
R
F
D
K
-----
V
S
N
K
M
R
L
Q
-----
G
M
-
K
-
M
V
S
A
S
S
I
--
S
--
D
P
I
I
Q
L
I
A
S
--
L
A
L
A
F
----
V
L
Y
A
A
S
F
P
-
S
V
M
D
S
L
T
A
G
T
IT
V
V
F
S
S
M
I
A
L
M
R
P
L
K
-------
S
L
-
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
-----
Q
---
E
K
D
E
-------
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
---
P
--
G
RE
V
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
-
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
--
A
Y
A
R--
T
E
-
E
---
Y
S
R
-
E
Q
I
E
E
A
A
R
M
-
A
Y
-------
A
M
D
F
I
N
K
M
D
N
G
L
D
T
-
I
I
G
-
E
-
N
-
G
-
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
----
N
-----
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
--
G
V
Y
A
Q
L
-------------------
32
PsiBlast_CBE
57.43
44%
-105
- C3 -
3NHB
3
A:
[54-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
E
N
V
H
F
S
Y
--
A
D
-----
R
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
-
Q
--
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
--
R
Y
G
---
R
V
-
T
---
A
G
N
-
D
E
V
E
A
A
A
Q
A
-
A
G
-------
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
-
Q
V
G
-
E
-
R
-
G
L
K
L
-
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
----
N
-----
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
--
G
V
Y
A
D
M
W
Q
L
Q
Q
G
-------------
19
PsiBlast_PDB
56.93
44%
-103
- C3 -
3NH9
3
A:
[54-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
E
N
V
H
F
S
Y
--
A
D
--
G
--
R
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
-
Q
--
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
--
R
Y
G
---
R
V
-
T
---
A
G
N
-
D
E
V
E
A
A
A
Q
A
-
A
G
-------
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
-
Q
V
G
-
E
-
R
-
G
L
K
L
-
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
----
N
-----
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
--
G
V
Y
A
D
M
W
Q
L
Q
Q
G
-------------
20
PsiBlast_PDB
56.64
44%
-101
- C3 -
3NHA
4
A:
[54-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
F
E
N
V
H
F
S
Y
--
A
D
-----
R
E
T
L
Q
D
-
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
-
Q
--
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
-
N
D
T
I
A
D
N
I
--
R
Y
G
---
R
V
-
T
---
A
G
N
-
D
E
V
E
A
A
A
Q
A
-
A
G
-------
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
-
Q
V
G
-
E
-
R
-
G
L
K
L
-
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
----
N
-----
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
--
G
V
Y
A
D
M
W
Q
L
Q
Q
G
-------------
30
PsiBlast_CBE
54.38
47%
-99
- C3 -
2ONJ
4
Y1866_STAAM
B:
[343-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
S
F
Q
Y
--
N
D
--
N
E-
A
P
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
-
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
--
L
L
G
---
R
P
-
T
---
A
T
D
-
E
E
V
V
E
A
A
K
M
-
A
N
-------
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
-
E
V
G
-
E
-
R
-
G
V
K
L
-
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
----
D
-----
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
------------------
14
PsiBlast_PDB
54.32
47%
-99
- C3 -
2ONJ
4
Y1866_STAAM
A:
[343-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
S
F
Q
Y
--
N
D
--
N
E-
A
P
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
-
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
--
L
L
G
---
R
P
-
T
---
A
T
D
-
E
E
V
V
E
A
A
K
M
-
A
N
-------
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
-
E
V
G
-
E
-
R
-
G
V
K
L
-
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
----
D
-----
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
------------------
31
PsiBlast_CBE
54.02
47%
-99
- C3 -
2HYD
3
Y1866_STAAM
B:
[343-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
S
F
Q
Y
--
N
D
--
N
E-
A
P
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
-
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
--
L
L
G
---
R
P
-
T
---
A
T
D
-
E
E
V
V
E
A
A
K
M
-
A
N
-------
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
-
E
V
G
-
E
-
R
-
G
V
K
L
-
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
----
D
-----
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
------------------
13
PsiBlast_PDB
53.86
47%
-99
- C3 -
2HYD
3
Y1866_STAAM
A:
[343-573]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
S
F
Q
Y
--
N
D
--
N
E-
A
P
I
L
K
D
-
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
-
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
-
S
D
T
V
K
E
N
I
--
L
L
G
---
R
P
-
T
---
A
T
D
-
E
E
V
V
E
A
A
K
M
-
A
N
-------
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
-
E
V
G
-
E
-
R
-
G
V
K
L
-
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
----
D
-----
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
--
G
A
Y
E
H
L
Y
------------------
56
PsiBlast_CBE
52.72
42%
-104
- C3 -
1XEF
3
HLYBP_ECOLX
C:
[2-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
50
PsiBlast_CBE
52.36
42%
-104
- C3 -
2FGJ
2
D:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
57
PsiBlast_CBE
52.33
42%
-101
- C3 -
1XEF
3
HLYBP_ECOLX
B:
[2-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
42
PsiBlast_CBE
51.87
42%
-102
- C3 -
2FGK
2
HLYBP_ECOLX
B:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
37
PsiBlast_CBE
51.63
42%
-98
- C3 -
2FF7
1
A:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
74
PsiBlast_CBE
51.58
39%
-93
- C3 -
2IXE
4
TAP1_RAT
A:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
W
A
--
S
-----
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
55
PsiBlast_CBE
51.58
42%
-99
- C3 -
1XEF
3
D:
[2-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
40
PsiBlast_CBE
51.54
42%
-102
- C3 -
2FGK
2
D:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
70
PsiBlast_CBE
51.46
39%
-91
- C3 -
2IXF
4
TAP1_RAT
C:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
W
A
--
S
-----
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
73
PsiBlast_CBE
51.45
39%
-98
- C3 -
2IXE
3
D:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
--
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
--------
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA--
S
-----
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
68
PsiBlast_CBE
51.36
41%
-97
- C3 -
1JJ7
2
A:
[15-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
F
Q
D
V
S
F
A
Y
PN
R
P
--
D
--
V
L
V
L
Q
G
-
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
-
Q
--
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
-
G
R
S
L
Q
E
N
I
--
A
Y
G
---
L
T
-
Q
---
K
P
T
M
E
E
I
T
A
A
A
V
K
-
S
G
-------
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
-
A
-
G
-
S
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
--
P
--
E
RY--
S
-----
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
--
G
C
Y
----------------------
58
PsiBlast_CBE
51.35
42%
-101
- C3 -
1XEF
3
HLYBP_ECOLX
A:
[2-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
71
PsiBlast_CBE
51.32
39%
-93
- C3 -
2IXF
4
TAP1_RAT
B:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA--
S
-----
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
36
PsiBlast_CBE
51.25
42%
-99
- C3 -
2PMK
1
A:
[4-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
75
PsiBlast_CBE
51.20
38%
-100
- C3 -
4K8O
4
A:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA--
S
-----
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
54
PsiBlast_CBE
50.93
42%
-96
- C3 -
2FFA
2
A:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
72
PsiBlast_CBE
50.73
39%
-91
- C3 -
2IXF
5
TAP1_RAT
A:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA--
S
-----
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
53
PsiBlast_CBE
50.69
42%
-96
- C3 -
2FGJ
2
HLYBP_ECOLX
A:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
76
PsiBlast_CBE
50.54
38%
-97
- C3 -
2IXG
2
A:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA--
S
-----
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
51
PsiBlast_CBE
50.11
42%
-99
- C3 -
2FGJ
2
HLYBP_ECOLX
C:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
44
PsiBlast_CBE
50.10
42%
-95
- C3 -
2FFB
1
A:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
39
PsiBlast_CBE
50.06
42%
-97
- C3 -
3B5J
1
A:
[4-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
52
PsiBlast_CBE
49.73
42%
-96
- C3 -
2FGJ
2
HLYBP_ECOLX
B:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
62
PsiBlast_CBE
49.64
35%
-98
- C3 -
3VX4
3
?
D:
[31-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
-------
G
D
---------
I
S
F
E
N
L
S
Y
K
Y
--
G
F
--
G
--
R
D
T
L
S
D
-
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
-
V
--
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
--
V
L
G
---
A
K
-
E
---
G
T
S
-
Q
E
D
I
I
R
A
C
E
I
A
E
-------
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
-
E
L
S
-
D
-
G
-
A
-
G
I
-
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
--
T
-------
E
-----
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
--
G
F
Y
Y
N
L
F
N
-----------------
69
PsiBlast_CBE
49.35
39%
-93
- C3 -
2IXF
4
D:
[17-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
Q
D
V
S
F
A
Y
PN
H
P
--
N
--
V
Q
V
L
Q
G
-
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
-
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
-
G
R
S
F
R
E
N
I
--
A
Y
G
---
L
T
-
R
---
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
-------
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
-
E
V
G
E
T
-
G
-
N
-
Q
L
-
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA--
S
-----
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
--
G
C
Y
----------------------
43
PsiBlast_CBE
48.67
42%
-98
- C3 -
2FGK
2
HLYBP_ECOLX
A:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
41
PsiBlast_CBE
48.44
42%
-97
- C3 -
2FGK
2
HLYBP_ECOLX
C:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
--
K
P
--
D
--
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
-
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
--
S
L
A
---
N
P
-
G
---
M
S
V
-
E
K
V
I
Y
A
A
K
L
-
A
G
-------
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
-
I
V
G
-
E
-
Q
G
A
-
G
L
-
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
----
G
-----
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-------------------------------
63
PsiBlast_CBE
48.10
35%
-94
- C3 -
3VX4
3
?
A:
[31-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
-------
G
D
---------
I
S
F
E
N
L
S
Y
K
Y
--
G
F
--
G
--
R
D
T
L
S
D
-
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
-
V
--
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
--
V
L
G
---
A
K
-
E
---
G
T
S
-
Q
E
D
I
I
R
A
C
E
I
A
E
-------
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
-
E
L
S
-
D
-
G
-
A
-
G
I
-
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
--
T
-------
E
-----
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
--
G
F
Y
Y
N
L
F
N
-----------------
45
PsiBlast_CBE
48.01
45%
-95
- C3 -
5DGX
1
A:
[33-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
S
G
-
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
-
E
--
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
-
D
D
T
V
Y
N
N
I
--
A
F
G
------
E
---
V
S
E
-
E
E
V
I
D
A
L
K
R
-
A
N
-------
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
-
N
I
G
-
N
-
N
G
S
-
K
L
-
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
--
T
--
K
----
S
-----
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
--
G
L
Y
T
R
L
Y
Q
S
G
---------------
67
PsiBlast_CBE
45.52
39%
-92
- C3 -
1MV5
3
LMRA_LACLA
A:
[6-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
--
D
D
--
S
--
E
Q
I
L
R
D
-
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
-
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
-
A
G
T
I
R
E
N
L
--
T
Y
G
---
L
E
G
D
---
Y
T
D
-
E
D
L
W
Q
V
L
D
L
-
A
F
-------
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
-
E
V
G
-
E
-
R
-
G
V
K
I
-
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
----
G
-----
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
--
P
L
Y
A
K
--------------------
89
PsiBlast_CBE
37.86
34%
-80
- C3 -
4U00
3
?
A:
[19-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
-
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
---
E
G
E
V
V
V
D
G
L
S
V
K
D
D
--
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
--
T
L
A
P
M
R
V
R
-
R
---
W
P
R
-
E
K
A
E
K
K
A
L
E
----------
L
L
E
R
V
G
I
L
----
D
Q
-
A
R
K
-
Y
-
P
-
A
-
Q
L
-
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
---
M
V
G
E
V
L
D
-
V
--
M
--
R
----
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
--------------------------------
81
PsiBlast_CBE
35.47
31%
-81
- C3 -
4YMV
1
?
J:
[16-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
-
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--
T
L
A
-----------
P
V
-
K
V
K
K
M
N
K
K
E
-
A
E
ELAVDLL
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
-----------
K
L
-
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
---
M
V
K
E
V
L
N
V
M
--
K
--
Q
LANE
G
-----
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
--------------------------------
83
PsiBlast_CBE
34.68
31%
-82
- C3 -
4YMU
2
?
J:
[16-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
-
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--
T
L
A
-----------
P
V
-
K
V
K
K
M
N
K
K
E
-
A
E
ELAVDLL
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
-----------
K
L
-
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
---
M
V
K
E
V
L
N
V
M
--
K
--
Q
LANE
G
-----
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
--------------------------------
84
PsiBlast_CBE
34.34
31%
-87
- C3 -
4YMU
2
?
A:
[16-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
-
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--
T
L
A
-----------
P
V
-
K
V
K
K
M
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
-----------
K
L
-
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
---
M
V
K
E
V
L
N
V
M
--
K
--
Q
L
A
N
E
G
-----
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
--------------------------------
82
PsiBlast_CBE
33.70
31%
-82
- C3 -
4YMV
1
?
A:
[16-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
-
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
-
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
--
T
L
A
-----------
P
V
-
K
V
K
K
M
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
-----------
K
L
-
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
---
M
V
K
E
V
L
N
V
M
--
K
--
Q
L
A
N
E
G
-----
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
--------------------------------