@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1372: (2016-05-01 )
MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
Atome Classification :
(20 SA)
.........10........20........30........40........50...---.....60...---.-...---.70--.........80....-----------....90.--.......100.......110.......120.......130.......140.......150.......160..-.....170.......180.......190.......200......--.210--..--.....220.......230.......240.......250.......260.......270.......280.......290.......300.----......-310.......320.......330.......340.......350.......360------.------..-..-------.-----.370........380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNVSAESGAPRRAGQRHEVGLAQLPPAPP
T
T
V
A
V
I
E
G
LATGTPRRVVNQ
S
D
A
A
D
---
R
V
A
E
L
FLDPG---Q-R
E
R
---
I
P
---
R
V
Y
Q
K
SRI
T
T
R
RMAV-----------DPLDA
K
F
--
D
V
FRREP
A
T
I
R
D
R
M
H
L
F
Y
EHAV
P
L
A
V
D
V
S
K
R
A
LAGLPYRA
A
E
I
G
L
L
V
L
ATSTGFIAPG
V
D
V
A
I
V
K
E
LGLSP
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
GTATN
Y
V
RA
H
P
A
M
K
A
L
V
V
C
I
E
L
CSV
N
--
A
V
FA--DD--
I
N
D
V
V
I
H
S
L
FGDG
C
A
A
L
VI
G
A
S
Q
V
Q
E
KLEPG
K
V
V
V
R
S
S
F
S
Q
L
LDNTED
G
I
V
L
G
V
NHN
G
I
T
C
E
LSENL
P
G
Y
I
FSG
V
A
P
V
V
T
E
M
L
WDNG
L
Q
----
I
S
D
I
D
L
-
W
A
IHPG
G
P
K
I
I
E
Q
S
V
R
SLGI
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
------
A
------
E
S-AK-------A-----IST-G
V
A
F
AFGPGVT
V
E
G
M
L
F
D
I
IRR
29
HHSearch
99.36
99%
-148
- C3 -
1TED
1
PKS18_MYCTU
A:
[22-392]
---------------------
A
Q
L
P
P
A
P
P
T
T
V
A
V
I
E
G
L
A
T
G
T
P
R
R
V
V
N
Q
S
D
A
A
D
---
R
V
A
E
L
----
G
---
Q
-
R
E
R
---
I
P
---
R
V
Y
Q
K
S
R
I
T
T
R
R
M
A
V
-----------
D
P
L
D
A
K
F
--
D
V
F
R
R
E
P
A
T
I
R
D
R
M
H
L
F
Y
E
H
A
V
P
L
A
V
D
V
S
K
R
A
L
A
G
L
P
Y
R
A
A
E
I
G
L
L
V
L
A
T
S
T
G
F
I
A
P
G
V
D
V
A
I
V
K
E
L
G
L
S
P
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
G
T
A
T
N
Y
V
R
A
H
P
A
M
K
A
L
V
V
C
I
E
L
C
S
V
N
--
A
V
F
A
--
D
D
--
I
N
D
V
V
I
H
S
L
F
G
D
G
C
A
A
L
V
I
G
A
S
Q
V
Q
E
K
L
E
P
G
K
V
V
V
R
S
S
F
S
Q
L
L
D
N
T
E
D
G
I
V
L
G
V
N
H
N
G
I
T
C
E
L
S
E
N
L
P
G
Y
I
F
S
G
V
A
P
V
V
T
E
M
L
W
D
N
G
L
Q
----
I
S
D
I
D
L
-
W
A
I
H
P
G
G
P
K
I
I
E
Q
S
V
R
S
L
G
I
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
-------------
A
E
S
A
K
-------
A
-----
I
S
T
-
G
V
A
F
A
F
G
P
G
V
T
V
E
G
M
L
F
D
I
I
R
-
1
PsiBlast_PDB
99.26
100%
-148
- C3 -
1TED
1
PKS18_MYCTU
A:
[22-393]
---------------------
A
Q
L
P
P
A
P
P
T
T
V
A
V
I
E
G
L
A
T
G
T
P
R
R
V
V
N
Q
S
D
A
A
D
---
R
V
A
E
L
----
G
---
Q
-
R
E
R
---
I
P
---
R
V
Y
Q
K
S
R
I
T
T
R
R
M
A
V
-----------
D
P
L
D
A
K
F
--
D
V
F
R
R
E
P
A
T
I
R
D
R
M
H
L
F
Y
E
H
A
V
P
L
A
V
D
V
S
K
R
A
L
A
G
L
P
Y
R
A
A
E
I
G
L
L
V
L
A
T
S
T
G
F
I
A
P
G
V
D
V
A
I
V
K
E
L
G
L
S
P
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
G
T
A
T
N
Y
V
R
A
H
P
A
M
K
A
L
V
V
C
I
E
L
C
S
V
N
--
A
V
F
A
--
D
D
--
I
N
D
V
V
I
H
S
L
F
G
D
G
C
A
A
L
V
I
G
A
S
Q
V
Q
E
K
L
E
P
G
K
V
V
V
R
S
S
F
S
Q
L
L
D
N
T
E
D
G
I
V
L
G
V
N
H
N
G
I
T
C
E
L
S
E
N
L
P
G
Y
I
F
S
G
V
A
P
V
V
T
E
M
L
W
D
N
G
L
Q
----
I
S
D
I
D
L
-
W
A
I
H
P
G
G
P
K
I
I
E
Q
S
V
R
S
L
G
I
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
------
A
------
E
S
-
A
K
-------
A
-----
I
S
T
-
G
V
A
F
A
F
G
P
G
V
T
V
E
G
M
L
F
D
I
I
R
R
22
PsiBlast_CBE
98.53
100%
-145
- C3 -
1TED
1
PKS18_MYCTU
C:
[22-393]
---------------------
A
Q
L
P
P
A
P
P
T
T
V
A
V
I
E
G
L
A
T
G
T
P
R
R
V
V
N
Q
S
D
A
A
D
---
R
V
A
E
L
----
G
---
Q
-
R
E
R
---
I
P
---
R
V
Y
Q
K
S
R
I
T
T
R
R
M
A
V
-----------
D
P
L
D
A
K
F
--
D
V
F
R
R
E
P
A
T
I
R
D
R
M
H
L
F
Y
E
H
A
V
P
L
A
V
D
V
S
K
R
A
L
A
G
L
P
Y
R
A
A
E
I
G
L
L
V
L
A
T
S
T
G
F
I
A
P
G
V
D
V
A
I
V
K
E
L
G
L
S
P
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
G
T
A
T
N
Y
V
R
A
H
P
A
M
K
A
L
V
V
C
I
E
L
C
S
V
N
--
A
V
F
A
--
D
D
--
I
N
D
V
V
I
H
S
L
F
G
D
G
C
A
A
L
V
I
G
A
S
Q
V
Q
E
K
L
E
P
G
K
V
V
V
R
S
S
F
S
Q
L
L
D
N
T
E
D
G
I
V
L
G
V
N
H
N
G
I
T
C
E
L
S
E
N
L
P
G
Y
I
F
S
G
V
A
P
V
V
T
E
M
L
W
D
N
G
L
Q
----
I
S
D
I
D
L
-
W
A
I
H
P
G
G
P
K
I
I
E
Q
S
V
R
S
L
G
I
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
------
A
------
E
S
-
A
K
-------
A
-----
I
S
T
-
G
V
A
F
A
F
G
P
G
V
T
V
E
G
M
L
F
D
I
I
R
R
2
PsiBlast_PDB
96.58
99%
-142
- C3 -
1TEE
-
PKS18_MYCTU
A:
[22-393]
---------------------
A
Q
L
P
P
A
P
P
T
T
V
A
V
I
E
G
L
A
T
G
T
P
R
R
V
V
N
Q
S
D
A
A
D
---
R
V
A
E
L
----
G
---
Q
-
R
E
R
---
I
P
---
R
V
Y
Q
K
S
R
I
T
T
R
R
M
A
V
-----------
D
P
L
D
A
K
F
--
D
V
F
R
R
E
P
A
T
I
R
D
R
M
H
L
F
Y
E
H
A
V
P
L
A
V
D
V
S
K
R
A
L
A
G
L
P
Y
R
A
A
E
I
G
L
L
V
L
A
T
S
T
G
F
I
A
P
G
V
D
V
A
I
V
K
E
L
G
L
S
P
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
G
T
A
T
N
Y
V
R
A
H
P
A
M
K
A
L
V
V
C
I
E
L
F
S
V
N
--
A
V
F
A
--
D
D
--
I
N
D
V
V
I
H
S
L
F
G
D
G
C
A
A
L
V
I
G
A
S
Q
V
Q
E
K
L
E
P
G
K
V
V
V
R
S
S
F
S
Q
L
L
D
N
T
E
D
G
I
V
L
G
V
N
H
N
G
I
T
C
E
L
S
E
N
L
P
G
Y
I
F
S
G
V
A
P
V
V
T
E
M
L
W
D
N
G
L
Q
----
I
S
D
I
D
L
-
W
A
I
H
P
G
G
P
K
I
I
E
Q
S
V
R
S
L
G
I
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
------
A
------
E
S
-
A
K
-------
A
-----
I
S
T
-
G
V
A
F
A
F
G
P
G
V
T
V
E
G
M
L
F
D
I
I
R
R
23
PsiBlast_CBE
96.20
100%
-146
- C3 -
1TED
1
PKS18_MYCTU
B:
[31-393]
------------------------------
T
V
A
V
I
E
G
L
A
T
G
T
P
R
R
V
V
N
Q
S
D
A
A
D
---
R
V
A
E
L
----
G
---
Q
-
R
E
R
---
I
P
---
R
V
Y
Q
K
S
R
I
T
T
R
R
M
A
V
-----------
D
P
L
D
A
K
F
--
D
V
F
R
R
E
P
A
T
I
R
D
R
M
H
L
F
Y
E
H
A
V
P
L
A
V
D
V
S
K
R
A
L
A
G
L
P
Y
R
A
A
E
I
G
L
L
V
L
A
T
S
T
G
F
I
A
P
G
V
D
V
A
I
V
K
E
L
G
L
S
P
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
G
T
A
T
N
Y
V
R
A
H
P
A
M
K
A
L
V
V
C
I
E
L
C
S
V
N
--
A
V
F
A
--
D
D
--
I
N
D
V
V
I
H
S
L
F
G
D
G
C
A
A
L
V
I
G
A
S
Q
V
Q
E
K
L
E
P
G
K
V
V
V
R
S
S
F
S
Q
L
L
D
N
T
E
D
G
I
V
L
G
V
N
H
N
G
I
T
C
E
L
S
E
N
L
P
G
Y
I
F
S
G
V
A
P
V
V
T
E
M
L
W
D
N
G
L
Q
----
I
S
D
I
D
L
-
W
A
I
H
P
G
G
P
K
I
I
E
Q
S
V
R
S
L
G
I
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
------
A
------
E
S
-
A
K
-------
A
-----
I
S
T
-
G
V
A
F
A
F
G
P
G
V
T
V
E
G
M
L
F
D
I
I
R
R
21
PsiBlast_CBE
95.75
100%
-147
- C3 -
1TED
1
PKS18_MYCTU
D:
[31-393]
------------------------------
T
V
A
V
I
E
G
L
A
T
G
T
P
R
R
V
V
N
Q
S
D
A
A
D
---
R
V
A
E
L
----
G
---
Q
-
R
E
R
---
I
P
---
R
V
Y
Q
K
S
R
I
T
T
R
R
M
A
V
-----------
D
P
L
D
A
K
F
--
D
V
F
R
R
E
P
A
T
I
R
D
R
M
H
L
F
Y
E
H
A
V
P
L
A
V
D
V
S
K
R
A
L
A
G
L
P
Y
R
A
A
E
I
G
L
L
V
L
A
T
S
T
G
F
I
A
P
G
V
D
V
A
I
V
K
E
L
G
L
S
P
S
-
I
S
R
V
V
V
N
F
M
G
C
A
A
A
M
N
A
L
G
T
A
T
N
Y
V
R
A
H
P
A
M
K
A
L
V
V
C
I
E
L
C
S
V
N
--
A
V
F
A
--
D
D
--
I
N
D
V
V
I
H
S
L
F
G
D
G
C
A
A
L
V
I
G
A
S
Q
V
Q
E
K
L
E
P
G
K
V
V
V
R
S
S
F
S
Q
L
L
D
N
T
E
D
G
I
V
L
G
V
N
H
N
G
I
T
C
E
L
S
E
N
L
P
G
Y
I
F
S
G
V
A
P
V
V
T
E
M
L
W
D
N
G
L
Q
----
I
S
D
I
D
L
-
W
A
I
H
P
G
G
P
K
I
I
E
Q
S
V
R
S
L
G
I
S
A
E
L
A
A
Q
S
W
D
V
L
A
R
F
G
N
M
L
S
V
S
L
I
F
V
L
E
T
M
V
Q
Q
------
A
------
E
S
-
A
K
-------
A
-----
I
S
T
-
G
V
A
F
A
F
G
P
G
V
T
V
E
G
M
L
F
D
I
I
R
R
3
PsiBlast_PDB
72.87
39%
-133
- C3 -
4B0N
3
?
A:
[40-411]
-----------------------------
T
V
Y
P
V
I
A
G
M
A
I
G
N
P
Q
Y
R
C
T
Q
N
E
A
L
A
---
V
A
S
K
C
---
P
G
---
L
-
E
S
I
---
K
P
V
L
E
R
I
Y
G
N
S
R
I
G
S
R
Y
F
A
V
PDFTPGRAAKG
D
P
L
F
Y
P
A
--
D
G
S
Y
Q
V
P
V
D
V
R
--
L
D
K
F
K
E
K
A
V
P
L
V
S
D
V
A
R
R
A
I
K
E
A
G
L
N
V
E
D
I
S
K
L
V
V
V
S
S
T
G
F
L
G
P
G
L
D
C
E
L
I
K
N
L
G
L
T
R
S
-
V
D
R
T
L
I
G
F
M
G
C
A
A
A
M
N
G
F
R
N
A
N
D
Y
V
T
A
N
P
G
K
Y
A
L
M
I
C
V
E
L
S
S
V
H
--
T
T
F
D
--
D
N
--
I
N
D
A
I
L
H
A
I
F
A
D
G
C
A
A
A
V
L
K
G
A
R
K
S
E
-
C
P
K
G
T
L
A
I
V
D
N
H
A
W
L
M
E
G
T
E
D
G
I
T
L
A
I
K
P
N
G
I
T
C
T
L
S
K
F
L
P
Q
Y
I
A
K
N
I
A
F
F
A
D
G
F
L
K
K
H
K
L
G
----
R
D
D
V
D
F
-
W
C
V
H
P
G
G
R
R
I
I
E
E
A
Q
N
G
L
G
L
S
E
E
Q
T
A
D
S
W
A
V
L
G
E
Y
G
N
M
L
S
P
S
V
M
F
V
L
S
R
V
F
K
R
------
H
------
N
A
-
A
L
-------
A
Q
GKPG
Y
Q
T
-
G
M
A
F
S
F
S
P
G
V
G
A
E
G
I
L
L
-----
24
PsiBlast_CBE
72.09
39%
-131
- C3 -
4B0N
3
?
B:
[40-411]
-----------------------------
T
V
Y
P
V
I
A
G
M
A
I
G
N
P
Q
Y
R
C
T
Q
N
E
A
L
A
---
V
A
S
K
C
---
P
G
---
L
-
E
S
I
---
K
P
VLE
R
I
Y
G
N
S
R
I
G
S
R
Y
F
A
V
PDFTPGRAAKG
D
P
L
F
Y
P
A
--
D
G
S
Y
Q
V
P
V
D
V
R
--
L
D
K
F
K
E
K
A
V
P
L
V
S
D
V
A
R
R
A
I
K
E
A
G
L
N
V
E
D
I
S
K
L
V
V
V
S
S
T
G
F
L
G
P
G
L
D
C
E
L
I
K
N
L
G
L
T
R
S
-
V
D
R
T
L
I
G
F
M
G
C
A
A
A
M
N
G
F
R
N
A
N
D
Y
V
T
A
N
P
G
K
Y
A
L
M
I
C
V
E
L
S
S
V
H
--
T
T
F
D
--
D
N
--
I
N
D
A
I
L
H
A
I
F
A
D
G
C
A
A
A
V
L
K
G
A
R
K
S
E
-
C
P
K
G
T
L
A
I
V
D
N
H
A
W
L
M
E
G
T
E
D
G
I
T
L
A
I
K
P
N
G
I
T
C
T
L
S
K
F
L
P
Q
Y
I
A
K
N
I
A
F
F
A
D
G
F
L
K
K
H
K
L
G
----
R
D
D
V
D
F
-
W
C
V
H
P
G
G
R
R
I
I
E
E
A
Q
N
G
L
G
L
S
E
E
Q
T
A
D
S
W
A
V
L
G
E
Y
G
N
M
L
S
P
S
V
M
F
V
L
S
R
V
F
K
R
------
H
------
N
A
-
A
L
-------
A
QGKPG
Y
Q
T
-
G
M
A
F
S
F
S
P
G
V
G
A
E
G
I
L
L
-----
7
PsiBlast_PDB
67.66
28%
-129
- C3 -
4JAO
1
PKS11_MYCTU
D:
[2-350]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
---
P
G
---
L
-
K
E
H
EEI
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
------------
P
L
Q
Q
Y
P
--
S
L
-----
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y-
P
A
V
K
--
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
------
R
------
P
P
-
S
G
--------------
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
-----
8
PsiBlast_PDB
67.63
28%
-130
- C3 -
4JAP
1
PKS11_MYCTU
D:
[2-350]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
---
P
G
---
L
-
K
E
H
EEI
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
------------
P
L
Q
Q
Y
P
--
S
L
-----
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y-
P
A
V
K
--
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
------
R
------
P
P
-
S
G
--------------
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
-----
17
PsiBlast_PDB
66.63
28%
-128
- C3 -
4JD3
1
PKS11_MYCTU
A:
[2-350]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
---
P
G
---
L
-
K
E
H
E
E
I
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
------------
P
L
Q
Q
Y
P
--
S
L
-----
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y-
P
A
V
K
--
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
------
R
------
P
P
-
S
G
--------------
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
-----
4
PsiBlast_PDB
66.43
32%
-121
- C3 -
2H84
1
PKS1_DICDI
A:
[18-370]
------------------------------------
G
I
G
I
S
V
P
G
E
P
I
S
Q
Q
S
L
K
D
---
S
I
S
N
D
F
S
D
K
A
---
E
T
N
E
K
---
V
K
---
R
I
F
E
Q
S
Q
I
K
T
R
H
L
V
R
-----------
D
Y
T
K
P
E
N
--
S
I
K
F
R
H
L
E
T
I
T
D
V
N
N
Q
F
K
K
V
V
P
D
L
A
Q
Q
A
C
L
R
A
L
K
D
W
G
G
D
K
G
D
I
T
H
I
V
S
V
T
S
T
G
I
I
I
P
D
V
N
F
K
L
I
D
L
L
G
L
N
K
D
-
V
E
R
V
S
L
N
L
M
G
C
L
A
G
L
S
S
L
R
T
A
A
S
L
A
K
A
S
P
R
N
R
I
L
V
V
C
T
E
V
C
S
L
H
--
F
S
N
T
--
D
G
--
G
D
Q
M
V
A
S
S
I
F
A
D
G
S
A
A
Y
I
I
G
C
N
P
R
I
E
--
E
T
P
L
Y
E
V
M
C
S
I
N
R
S
F
P
N
T
E
N
A
M
V
W
D
L
E
K
E
G
W
N
L
G
L
D
A
S
I
P
I
V
I
G
S
G
I
E
A
F
V
D
T
L
L
D
K
A
K
L
Q
TSTA
I
S
A
K
D
C
E
F
L
I
H
T
G
G
K
S
I
L
M
N
I
E
N
S
L
G
I
D
P
K
Q
T
K
N
T
W
D
V
Y
H
A
Y
G
N
M
S
S
A
S
V
I
F
V
M
D
----
H
------
A
------
R
K
-
S
K
-------
S
-----
L
P
T
Y
S
I
S
L
A
F
G
P
G
L
A
F
E
G
C
F
L
-----
16
PsiBlast_PDB
66.14
28%
-126
- C3 -
4JAT
1
PKS11_MYCTU
A:
[2-350]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
---
P
G
---
L
-
K
E
H
E
E
I
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
------------
P
L
Q
Q
Y
P
--
S
L
-----
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y-
P
A
V
K
--
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
------
R
------
P
P
-
S
G
--------------
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
-----
9
PsiBlast_PDB
66.01
28%
-126
- C3 -
4JAQ
1
PKS11_MYCTU
D:
[2-350]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
---
P
G
---
L
-
K
E
H
EEI
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
------------
P
L
Q
Q
Y
P
--
S
L
-----
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y-
P
A
V
K
--
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
------
R
------
P
P
-
S
G
--------------
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
-----
10
PsiBlast_PDB
65.63
28%
-128
- C3 -
4JAR
-
PKS11_MYCTU
A:
[2-350]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
---
P
G
---
L
-
K
E
H
E
E
I
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
------------
P
L
Q
Q
Y
P
--
S
L
-----
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y-
P
A
V
K
--
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
------
R
------
P
P
-
S
G
--------------
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
-----
18
PsiBlast_PDB
64.62
26%
-107
- C3 -
1I8B
-
CHS2_MEDSA
A:
[6-380]
-----------------
E
I
R
K
A
Q
R
A
E
G
P
A
T
I
L
A
I
----
G
T
A
N
P
A
N
C
V
E
Q
S
T
Y
P
D
F
Y
F
K
I
T
N
S
E
H
K
T
E
---
L
-
K
E
K
---
F
Q
---
R
M
C
D
K
S
M
I
K
R
R
Y
M
Y
L
T
E
---------
E
I
L
K
E
N
P
--
N
V
C
E
Y
M
A
P
S
L
D
A
R
Q
D
M
V
V
V
E
V
P
R
L
G
K
E
A
A
V
K
A
I
K
E
W
G
Q
P
K
S
K
I
T
H
L
I
V
C
T
T
S
G
V
D
M
P
G
A
D
Y
Q
L
T
K
L
L
G
L
R
P
Y
-
V
K
R
Y
M
M
Y
Q
Q
G
-
F
A
G
G
T
V
L
R
L
A
K
D
L
A
E
N
N
K
G
A
R
V
L
V
V
C
S
E
V
T
A
V
T
--
F
R
G
P
--
S
D
TH
L
D
S
L
V
G
Q
A
L
F
G
D
G
A
A
A
L
I
V
G
S
D
P
V
P
E
I
E
K
P
I
F
E
M
V
W
T
A
-
Q
T
I
A
P
D
S
E
G
A
I
D
F
H
L
R
E
A
G
L
T
F
H
L
L
K
D
V
P
G
I
V
S
K
N
I
T
K
A
L
V
E
A
F
E
P
L
G
I
S
----
D
Y
N
S
I
F
-
W
I
A
H
P
G
G
P
A
I
L
D
Q
V
E
Q
K
L
A
L
K
P
E
K
M
N
A
T
R
E
V
L
S
E
Y
G
N
M
S
S
A
C
V
L
F
I
L
D
E
M
R
K
K
------
S
T
Q
N
GLK
T
T
-
G
E
-------
G
-----
L
E
W
-
G
V
L
F
G
F
G
P
G
L
T
I
E
---------
13
PsiBlast_PDB
64.60
26%
-110
- C3 -
1CGK
1
CHS2_MEDSA
A:
[6-380]
-----------------
E
I
R
K
A
Q
R
A
E
G
P
A
T
I
L
A
I
----
G
T
A
N
P
A
N
C
V
E
Q
S
T
Y
P
D
F
Y
F
K
I
T
N
S
E
H
K
T
E
---
L
-
K
E
K
---
F
Q
---
R
M
C
D
K
S
M
I
K
R
R
Y
M
Y
L
T
E
---------
E
I
L
K
E
N
P
--
N
V
C
E
Y
M
A
P
S
L
D
A
R
Q
D
M
V
V
V
E
V
P
R
L
G
K
E
A
A
V
K
A
I
K
E
W
G
Q
P
K
S
K
I
T
H
L
I
V
C
T
T
S
G
V
D
M
P
G
A
D
Y
Q
L
T
K
L
L
G
L
R
P
Y
-
V
K
R
Y
M
M
Y
Q
Q
G
C
F
A
G
G
T
V
L
R
L
A
K
D
L
A
E
N
N
K
G
A
R
V
L
V
V
C
S
E
V
T
A
V
T
--
F
R
G
P
--
S
D
TH
L
D
S
L
V
G
Q
A
L
F
G
D
G
A
A
A
L
I
V
G
S
D
P
V
P
E
I
E
K
P
I
F
E
M
V
W
T
A
-
Q
T
I
A
P
D
S
E
G
A
I
D
G
H
L
R
E
A
G
L
T
F
H
L
L
K
D
V
P
G
I
V
S
K
N
I
T
K
A
L
V
E
A
F
E
P
L
G
I
S
----
D
Y
N
-
I
F
-
W
I
A
H
P
G
G
P
A
I
L
D
Q
V
E
Q
K
L
A
L
K
P
E
K
M
N
A
T
R
E
V
L
S
E
Y
G
N
M
S
S
A
C
V
L
F
I
L
D
E
M
R
K
K
------
S
T
Q
N
GLK
T
T
-
G
E
-------
G
-----
L
E
W
-
G
V
L
F
G
F
G
P
G
L
T
I
E
---------
25
HHSearch
64.57
28%
-122
- C3 -
4JAQ
1
PKS11_MYCTU
D:
[2-352]
--------------------------------
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
---
S
F
V
E
F
P
G
L
K
E
---
H
-
E
E
I
---
I
R
---
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
-----------
P
L
Q
Q
Y
--------
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
-
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
--
Y
P
A
V
K-
P
T
--
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
V
R
A
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
----
K
D
D
I
G
A
-
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
--------------
R
-
P
P
-------
S
-----
G
S
A
-
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
---
11
PsiBlast_PDB
64.52
27%
-110
- C3 -
4YJY
-
?
A:
[9-383]
-----------------
E
V
R
R
A
Q
R
A
E
G
P
A
T
V
L
A
I
----
G
T
A
T
P
A
N
C
V
Y
Q
A
D
Y
P
D
Y
Y
F
R
I
T
K
S
E
H
M
V
E
---
L
-
K
E
K
---
F
K
---
R
M
C
D
K
S
Q
I
R
K
R
Y
M
H
L
T
E
---------
E
I
L
Q
E
N
P
--
N
M
C
A
Y
M
A
P
S
L
D
A
R
Q
D
I
V
V
V
E
V
P
K
L
G
K
A
A
A
Q
K
A
I
K
E
W
G
Q
P
R
S
R
I
T
H
L
V
F
C
T
T
S
G
V
D
M
P
G
A
D
Y
Q
L
A
K
M
L
G
L
R
P
N
-
V
S
R
L
M
M
Y
Q
Q
G
C
F
A
G
G
T
V
L
R
V
A
K
D
L
A
E
N
N
R
G
A
R
V
L
A
V
C
S
E
I
T
A
V
T
F
R
G
P
S
E
--
S
H
--
L
D
S
M
V
G
Q
A
L
F
G
D
G
A
A
A
V
I
V
G
-
S
D
P
D
E
A
V
E
R
P
L
F
Q
M
V
S
A
S
Q
T
I
L
P
D
S
E
G
A
I
D
G
H
L
R
E
V
G
L
T
F
H
L
L
K
D
V
P
G
L
I
S
K
N
I
E
R
A
L
G
D
A
F
T
P
L
G
I
S
----
D
W
N
S
I
F
-
W
V
A
H
P
G
G
P
A
I
L
D
Q
V
E
A
K
V
G
L
D
K
E
R
M
R
A
T
R
H
V
L
S
E
Y
G
N
M
S
S
A
C
V
L
F
I
L
D
E
M
R
K
R
S
A
E
D
GH
A
------
T
T
-
G
E
-------
G
-----
M
D
W
-
G
V
L
F
G
F
G
P
G
L
T
V
E
---------
41
HHSearch
63.93
26%
-114
* C3 *
3TSY
-
A:
[599-976]
---------------------------
R
A
K
G
P
A
T
I
L
A
I
G
T
A
T
P
D
H
C
V
Y
Q
S
D
Y
A
D
---
Y
Y
F
K
V
T
K
S
E
H
M
T
A
L
-
K
K
K
---
F
N
---
R
I
C
D
K
S
M
I
K
K
R
Y
I
H
L
-----------
T
E
E
M
L
E
E
H
P
N
I
G
A
Y
M
A
P
S
L
N
I
R
Q
E
I
I
T
A
E
V
P
K
L
G
K
E
A
A
L
K
A
L
K
E
W
G
Q
P
K
S
K
I
T
H
L
V
F
C
T
T
S
G
V
E
M
P
G
A
D
Y
K
L
A
N
L
L
G
L
E
P
S
V
R
R
V
M
L
Y
H
-
Q
G
C
Y
A
G
G
T
V
L
R
T
A
K
D
L
A
E
N
N
A
G
A
R
V
L
V
V
C
S
E
I
T
V
V
T
--
F
R
G
P
S
E
D
A
--
L
D
S
L
V
G
Q
A
L
F
G
D
G
S
A
A
V
I
V
G
S
D
P
D
I
S
-
I
E
R
P
L
F
Q
L
V
S
A
A
Q
T
F
I
P
N
S
A
G
A
I
A
G
N
L
R
E
V
G
L
T
F
H
L
W
P
N
V
P
T
L
I
S
E
N
V
E
K
C
L
T
Q
A
F
D
P
L
G
I
S
----
D
W
N
S
L
F
-
W
I
A
H
P
G
G
P
A
I
L
D
A
V
E
A
K
L
N
L
D
K
K
K
L
E
A
T
R
H
V
L
S
E
Y
G
N
M
S
S
A
C
V
L
F
I
L
D
E
M
R
K
K
-------------
S
L
-
K
G
ERATTGE
G
-----
L
D
W
-
G
V
L
F
G
F
G
P
G
L
T
I
E
T
V
V
L
H
S
I
P
M