@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1512: (2016-05-02 )
MNAHTSVGPLDRAARVYIAGHRGLVGSALLRTFAGAGFTNLLVRSRAELDLTDRAATFDFVLESRPQVVIDAAARVGGILANDTYPADFLSENLQIQVNLLDAAVAARVPRLLFLGSSCIYPKLAPQPIPESALLTGPLEPTNDAYAIAKIAGILAVQAVRRQHGLPWISAMPTNLYGPGDNFSPSGSHLLPALIRRYDEAKASGAPNVTNWGTGTPRRELLHVDDLASACLYLLEHFDGPTHVNVGTGIDHTIGEIAEMVASAVGYSGETRWDPSKPDGTPRKLLDVSVLREAGWRPSIALRDGIEATVAWYREHAGTVRQ
Atome Classification :
(23 SA)
.........10........20........30...-....--.40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230....-------..---------.--240-........250.......260.......270.......280.......290.......300--........310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNAHTSVGPLDR
A
A
R
V
Y
I
AGHR
G
L
V
G
S
A
L
L
R
T
F
A-GA
G
F
--
T
N
L
L
V
RSRAELDLTDRA
A
T
F
D
F
V
LESRP
Q
V
V
I
D
A
A
A
RV
G
G
I
LANDTY
P
A
D
F
LSEN
L
Q
I
Q
V
N
L
L
D
A
A
V
A
A
RVP
R
L
L
F
LGSSCIYPKLAPQPIPESALLTGPLEPTN
D
A
Y
A
I
A
K
I
A
G
I
L
A
V
Q
A
V
R
R
QHGLPWISAMPTNLYGPGDNFSPSG
S
H
L
L
P
A
L
I
R
R
Y
D
E
AKASGAPNVTNWGTGTPRR
E
L
L
H
V
D
D
L
A
S
A
C
L
Y
L
L
E
-------HF---------D--GP--
T
H
V
N
VGTGI
D
H
T
I
G
E
I
A
E
M
V
A
S
AVGYSGETRWDPSKPDGT
P
R
K
L
L
D
V
S
V
L
R
EAGWRP
S
I
A
---LRDG
I
E
A
T
V
A
W
Y
R
E
HAGTVRQ
1
PsiBlast_PDB
96.50
53%
-108
- C1 -
1BSV
1
FCL_ECOLI
A:
[5-319]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
F
--
7
PsiBlast_PDB
96.05
52%
-106
- C1 -
1E7Q
7
FCL_ECOLI
A:
[5-316]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
A
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
50
HHSearch
95.93
54%
-106
- C1 -
1E6U
7
FCL_ECOLI
A:
[2-316]
-----------
A
K
Q
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
K
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
-------
L
A
H
E
V
W
L
E
N
T
Q
P
--
M
L
--
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
3
PsiBlast_PDB
95.77
53%
-108
- C1 -
1GFS
-
FCL_ECOLI
A:
[5-319]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
F
--
4
PsiBlast_PDB
95.74
53%
-107
- C1 -
1E6U
7
FCL_ECOLI
A:
[5-316]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
K
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
2
PsiBlast_PDB
95.70
53%
-107
- C1 -
1FXS
1
FCL_ECOLI
A:
[5-319]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
D
R
F
--
8
PsiBlast_PDB
95.46
52%
-108
- C1 -
1E7R
6
FCL_ECOLI
A:
[5-316]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
E
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
5
PsiBlast_PDB
94.97
52%
-108
- C1 -
1E7S
6
FCL_ECOLI
A:
[5-316]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
R
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
S
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
E
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
6
PsiBlast_PDB
89.56
52%
-106
- C1 -
1BWS
1
FCL_ECOLI
A:
[5-316]
--------------
R
V
F
I
A
G
H
R
G
M
V
G
S
A
I
R
R
Q
L
E
-
Q
R
G
D
--
V
E
L
V
L
R
T
R
D
E
L
N
L
L
D
S
R
A
V
H
D
F
F
A
S
E
R
I
D
Q
V
Y
L
A
A
A
K
V
G
G
I
V
A
N
N
T
Y
P
A
D
F
I
Y
Q
N
M
M
I
E
S
N
I
I
H
A
A
H
Q
N
D
V
N
K
L
L
F
L
G
S
S
C
I
Y
P
K
L
A
K
Q
P
M
A
E
S
E
L
L
Q
G
T
L
E
P
T
N
E
P
Y
A
I
A
K
I
A
G
I
K
L
C
E
S
Y
N
R
Q
Y
G
R
D
Y
R
S
V
M
P
T
N
L
Y
G
P
H
D
N
F
H
P
S
N
S
H
V
I
P
A
L
L
R
R
F
H
E
A
T
A
Q
N
A
P
D
V
V
V
W
G
S
G
T
P
M
R
E
F
L
H
V
D
D
M
A
A
A
S
I
H
V
M
E
LA
H
E
V
W
L
E
N
---------
T
--
Q
P
ML
S
H
I
N
V
G
T
G
V
D
C
T
I
R
D
L
A
Q
T
I
A
K
V
V
G
Y
K
G
R
V
V
F
D
A
S
K
P
D
G
T
P
R
K
L
L
D
V
T
R
L
H
Q
L
G
W
Y
H
E
I
S
---
L
E
A
G
L
A
S
T
Y
Q
W
F
L
E
N
Q
-----
36
PsiBlast_CBE
77.62
32%
-101
- C1 -
4B8Z
2
FCL_HUMAN
C:
[8-320]
-------------
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
33
PsiBlast_CBE
77.45
32%
-103
- C1 -
4BKP
1
FCL_HUMAN
C:
[21-336]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
K
35
PsiBlast_CBE
76.64
32%
-101
- C1 -
4B8Z
2
FCL_HUMAN
D:
[8-320]
-------------
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
34
PsiBlast_CBE
76.63
32%
-105
- C1 -
4BKP
2
FCL_HUMAN
B:
[21-335]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
11
PsiBlast_PDB
76.62
32%
-103
- C1 -
4B8Z
2
FCL_HUMAN
A:
[8-315]
-------------
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
------
32
PsiBlast_CBE
76.16
32%
-104
- C1 -
4BKP
2
FCL_HUMAN
D:
[21-335]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
29
PsiBlast_CBE
75.90
32%
-97
- C1 -
4BL5
2
FCL_HUMAN
D:
[22-336]
------------
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
K
9
PsiBlast_PDB
75.58
32%
-104
- C1 -
4BKP
2
FCL_HUMAN
A:
[21-335]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
28
PsiBlast_CBE
75.33
32%
-98
- C1 -
4BL5
2
FCL_HUMAN
E:
[21-335]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
27
PsiBlast_CBE
75.24
32%
-103
- C1 -
4BL5
3
FCL_HUMAN
F:
[23-335]
-------------
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
26
PsiBlast_CBE
74.96
32%
-99
- C1 -
4BL5
1
FCL_HUMAN
G:
[21-335]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
37
PsiBlast_CBE
74.81
32%
-101
- C1 -
4B8Z
2
FCL_HUMAN
B:
[6-320]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-
38
PsiBlast_CBE
74.57
32%
-105
- C1 -
4B8W
2
FCL_HUMAN
B:
[5-316]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
-----PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
---------
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
FTP
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
----
12
PsiBlast_PDB
74.36
32%
-98
- C1 -
4B8W
2
FCL_HUMAN
A:
[5-319]
-----------
Q
S
M
R
I
L
V
T
G
G
S
G
L
V
G
K
A
I
Q
K
V
V
A
D
G
A
G
L
PG
E
D
W
V
F
V
S
S
K
D
A
D
L
T
D
T
A
Q
T
R
A
L
F
E
K
V
Q
P
T
H
V
I
H
L
A
A
M
V
G
G
L
F
R
N
I
K
Y
N
L
D
F
W
R
K
N
V
H
M
N
D
N
V
L
H
S
A
F
E
V
G
A
R
K
V
V
S
C
L
S
T
C
I
F
P
D
K
T
T
Y
P
I
D
E
T
M
I
H
N
G
P
P
H
N
S
N
F
G
Y
S
Y
A
K
R
M
I
D
V
Q
N
R
A
Y
F
Q
Q
Y
G
C
T
F
T
A
V
I
P
T
N
V
F
G
P
H
D
N
F
N
I
E
D
G
H
V
L
P
G
L
I
H
K
V
H
L
A
K
S
S
G
S
A
-
L
T
V
W
G
T
G
N
P
R
R
Q
F
I
Y
S
L
D
L
A
Q
L
F
I
W
V
L
R
-------
E
Y
---------
N
EV
E
P
--
I
I
L
S
V
G
E
E
D
E
V
S
I
K
E
A
A
E
A
V
V
E
A
M
D
F
H
G
E
V
T
F
D
T
T
K
S
D
G
Q
F
K
K
T
A
S
N
S
K
L
R
T
--
Y
L
P
D
F
R
F
T
P
F
K
Q
A
V
K
E
T
C
A
W
F
T
D
N
Y
E
Q
A
R
-