@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1798: (2016-05-05 )
MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAVELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADAEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRFSTVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.--.......90........-100.---......110.......120.......130.......140.......150.......160.......170.......180........190.......200.......210--........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370..-.....380.......390.......400.......410---.......420.......430.......440.......450--.----.......460.......470------------........480.......490.......----500.--......510....--...520.......530.--------......540..-.....550.......560.....-..570---.---------------...----------------------.----------..580.--.--.....590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRP
Q
A
A
A
E
D
A
R
N
A
M
V
A
G
L
L
ASG
I
S
VNGLQPSH
N
P
Q
V
A
A
Q
M
F
T
T
ATRL
D
P
K
M
C
D
A
W
L
A
R
L
LAGDQ
S
I
E
V
L
A
G
A
W
A
A
V
R
TFGW--ETRRLGVTD
L
Q
FRPEVS-D
G
L
F
---
L
R
L
A
IT
S
V
D
S
L
A
C
A
Y
A
A
V
L
A
E
A
K
R
Y
Q
E
A
A
E
L
LDATDPRHP
F
D
A
E
L
V
S
Y
V
R
G
V
L
Y
F
RTKR
W
P
D
V
L
A
QFPEATQWRHP
E
L
-KAA
G
A
A
M
A
T
T
A
L
A
S
L
G
V
F
E
E
A
F
R
R
A
Q
E
A
IE---GDRVPGA
A
N
I
A
L
Y
TQ
G
M
C
L
R
HVGR
E
E
E
A
V
E
L
L
R
R
V
Y
SRDAKFT
P
A
R
E
ALDNP
N
F
R
L
I
LTDPETIEARTDPWDPDSAPT
R
A
Q
T
E
A
A
R
H
A
E
M
A
A
K
Y
L
AEGD
A
E
L
N
A
M
L
G
M
E
Q
A
K
K
E
I
K
L
I
KST
T
K
V
N
L
A
R
AKMGLPVPVTSR
H
T
L
L
L
GPPGT
G
K
T
S
V
A
R
A
F
T
K
Q
L
-
C
G
L
T
V
LRK
P
L
V
V
ET
S
R
T
K
L
L
G
R
Y
M
ADAEK
N
T
E
E
M
L
E
G
A---LGG
A
V
F
F
D
E
M
H
T
L
H
EKGYSQGDPY
G
N
A
I
I
N
T
L
L
L
Y
M
ENH---R----D
E
L
V
V
FGA
G
Y
A
K
A
M
E
K
M
L
E
-------------
V
N
Q
G
L
R
R
R
F
S
T
V
I
E
F
FSY
T
P
Q
E
L
I
A
L
T
Q
----
L
MGR--ENEDVITEEES
Q
V
--L
L
P
S
Y
T
K
F
Y
M
E
QSYSED--------G
D
L
I
R
G
I
D
LLG-N
A
G
F
V
R
N
V
V
E
K
A
R
DHRSFRL
D
D
E
-
D
L
D
A
V
---
L
---------------
A
S
D
----------------------
L
----------
T
E
F
S
E
D
--
Q
--
L
R
R
F
K
E
L
T
R
E
D
L
A
E
G
L
R
A
A
V
A
EKKTK
3
PsiBlast_PDB
91.31
30%
-66
- C3 -
3SYK
3
CBBX_RHOSH
A:
[3-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
A
T
A
P
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
A
H
E
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
-----
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
---
E
----
I
A
G
H
M
L
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
----
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
24
PsiBlast_CBE
91.09
31%
-63
- C3 -
3ZUH
2
CBBX_RHOSH
C:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
S
I
D
L
R
A
E
Y
E
G
S
----
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
N
E
R
--
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
-
S
S
G
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
25
PsiBlast_CBE
90.94
31%
-64
- C3 -
3ZUH
2
CBBX_RHOSH
B:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
S
I
D
L
R
A
E
Y
E
G
S
----
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
N
E
R
--
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
-
S
S
G
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
21
PsiBlast_CBE
90.93
31%
-63
- C3 -
3ZUH
2
CBBX_RHOSH
F:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
S
I
D
L
R
A
E
Y
E
G
S
----
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
N
E
R
--
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
-
S
S
G
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
1
PsiBlast_PDB
90.90
31%
-61
- C3 -
3SYL
3
CBBX_RHOSH
A:
[3-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
A
T
A
P
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
A
H
E
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
-----
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
----
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
22
PsiBlast_CBE
90.79
31%
-64
- C3 -
3ZUH
2
CBBX_RHOSH
E:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
S
I
D
L
R
A
E
Y
E
G
S
----
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
N
E
R
--
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
-
S
S
G
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
2
PsiBlast_PDB
90.62
31%
-64
- C3 -
3ZUH
2
CBBX_RHOSH
A:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
S
I
D
L
R
A
E
Y
E
G
S
----
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
N
E
R
--
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
-
S
S
G
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
23
PsiBlast_CBE
90.52
31%
-64
- C3 -
3ZUH
2
CBBX_RHOSH
D:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
S
I
D
L
R
A
E
Y
E
G
S
----
G
A
K
E
V
L
E
E
L
D
R
E
L
---
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
-
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
K
R
A
---
M
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P
D
N
E
R
--
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
E
N
N
---
R
----
D
D
L
V
V
I
L
A
G
Y
A
D
R
M
E
N
F
F
Q
-------------
S
N
P
G
F
R
S
R
I
A
H
H
I
E
F
P
D
Y
S
D
E
E
L
F
E
I
A
G
----
H
M
-
L
--
D
D
Q
N
Y
Q
M
T
P
E
A
E
T
--
A
L
R
A
Y
I
G
L
R
R
N
Q
P
H
--------------------
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
Q
A
N
R
L
F
T
A
-
S
S
G
P
L
---
D
---------------
A
R
A
----------------------
L
----------
S
T
I
A
E
E
--
D
--
I
R
------------------------
52
Fugue
86.17
29%
-83
- C2 -
4F3V
6
ECCA1_MYCTU
A:
[1-275]
---------
G
H
M
T
D
R
L
A
S
L
F
E
S
A
V
S
M
----
L
P
M
S
E
A
R
S
L
D
L
F
T
E
I
T
N
Y
D
E
S
A
C
D
A
W
I
G
R
I
R
C
G
D
T
D
R
V
T
L
F
R
A
W
Y
S
R
R
N
F
G
Q
--
L
S
G
S
V
Q
I
S
M
S
T
L
N
A
R
I
A
I
G
G
L
Y
GD-
I
T
Y
P
V
T
S
P
L
A
I
T
M
G
F
A
A
C
E
A
A
Q
G
N
Y
A
D
A
M
E
A
L
E
A
A
P
V
A
G
S
--
E
H
L
V
A
W
M
K
A
V
V
Y
G
A
A
E
R
W
T
D
V
I
D
Q
V
K
S
A
G
K
W
P
D
K
F
L
-
A
G
A
A
G
V
A
H
G
V
A
A
A
N
L
A
L
F
T
E
A
E
R
R
L
T
E
A
N
D
---
S
P
A
G
E
A
C
A
R
A
I
A
W
Y
L
A
M
A
R
R
S
Q
G
N
E
S
A
A
V
A
L
L
E
W
L
Q
T
T
H
P
E
-
P
K
V
A
A
A
L
K
D
P
S
Y
R
L
K
T
T
T
A
E
Q
I
A
S
R
A
D
P
W
D
P
G
S
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.02
31%
-84
- C2 -
4F3V
6
ECCA1_MYCTU
A:
[28-275]
----------------------------------------
L
F
T
E
I
T
N
Y
D
E
S
A
C
D
A
W
I
G
R
I
R
C
G
D
T
D
R
V
T
L
F
R
A
W
Y
S
R
R
N
F
G
Q
L
S
G
S
V
Q
I
S
M
S
T
L
N
A
R
I
A
I
G
--
G
L
Y
GD-
I
T
Y
P
V
T
S
P
L
A
I
T
M
G
F
A
A
C
E
A
A
Q
G
N
Y
A
D
A
M
E
A
L
E
A
A
P
V
A
G
--
S
E
H
L
V
A
W
M
K
A
V
V
Y
G
A
A
E
R
W
T
D
V
I
D
Q
V
K
S
A
G
K
W
P
D
K
F
L
-
A
G
A
A
G
V
A
H
G
V
A
A
A
N
L
A
L
F
T
E
A
E
R
R
L
T
E
A
N
D
---
S
P
A
G
E
A
C
A
R
A
I
A
W
Y
L
A
M
A
R
R
S
Q
G
N
E
S
A
A
V
A
L
L
E
W
L
Q
T
T
H
P
E
P
K
V
A
-
A
A
L
K
D
P
S
Y
R
L
K
T
T
T
A
E
Q
I
A
S
R
A
D
P
W
D
P
G
S
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.92
31%
-84
- C2 -
4F3V
3
ECCA1_MYCTU
B:
[28-274]
----------------------------------------
L
F
T
E
I
T
N
Y
D
E
S
A
C
D
A
W
I
G
R
I
R
C
G
D
T
D
R
V
T
L
F
R
A
W
Y
S
R
R
N
F
G
Q
L
S
G
S
V
Q
I
S
M
S
T
L
N
A
R
I
A
I
G
--
G
L
Y
GD-
I
T
Y
P
V
T
S
P
L
A
I
T
M
G
F
A
A
C
E
A
A
Q
G
N
Y
A
D
A
M
E
A
L
E
A
A
P
V
A
G
--
S
E
H
L
V
A
W
M
K
A
V
V
Y
G
A
A
E
R
W
T
D
V
I
D
Q
V
K
S
A
G
K
W
P
D
K
F
L
-
A
G
A
A
G
V
A
H
G
V
A
A
A
N
L
A
L
F
T
E
A
E
R
R
L
T
E
A
N
D
---
S
P
A
G
E
A
C
A
R
A
I
A
W
Y
L
A
M
A
R
R
S
Q
G
N
E
S
A
A
V
A
L
L
E
W
L
Q
T
T
H
P
E
P
K
V
A
-
A
A
L
K
D
P
S
Y
R
L
K
T
T
T
A
E
Q
I
A
S
R
A
D
P
W
D
P
G
S
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
78.52
30%
-82
- C2 -
4F3V
6
ECCA1_MYCTU
A:
[21-270]
---------------------------------
S
E
A
R
S
L
D
L
F
T
E
I
T
N
Y
D
E
S
A
C
D
A
W
I
G
R
I
R
C
G
D
T
D
R
V
T
L
F
R
A
W
Y
S
R
R
N
F
G
Q
--
L
S
G
S
V
Q
I
S
M
S
T
L
N
A
R
I
A
-
I
G
G
L
YGD
I
T
Y
P
V
T
S
P
L
A
I
T
M
G
F
A
A
C
E
A
A
Q
G
N
Y
A
D
A
M
E
A
L
E
A
A
P
V
A
--
G
S
E
H
L
V
A
W
M
K
A
V
V
Y
G
A
A
E
R
W
T
D
V
I
D
Q
V
K
S
A
G
K
-
W
P
D
K
F
L
A
G
A
A
G
V
A
H
G
V
A
A
A
N
L
A
L
F
T
E
A
E
R
R
L
T
E
A
N
D
SPA
G
E
---
A
C
A
R
A
I
A
W
Y
L
A
M
A
R
R
S
Q
G
N
E
S
A
A
V
A
L
L
E
W
L
Q
T
T
H
P
-
E
P
K
V
A
A
A
L
K
D
P
S
Y
R
L
K
T
T
T
A
E
Q
I
A
S
R
A
D
P
W
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.90
24%
-49
- C3 -
4L16
1
FIGL1_CAEEL
A:
[60-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
E
G
A
K
K
A
L
R
E
I
---
V
V
L
P
F
K
R
P
D
V
F
T
G
I
R
A
P
P
K
G
V
L
L
F
G
P
P
G
T
G
K
T
M
I
G
R
C
V
A
S
Q
--
C
K
A
T
F
F
------
N
I
S
A
S
S
L
T
S
K
W
V
G
E
G
E
K
L
V
R
A
L
F
S
V
A
R
L
K
L
P
S
V
I
F
I
D
E
I
D
S
L
L
S
-------
E
S
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
V
---
N
T
A
PD
E
R
L
L
V
L
G
-----
A
T
N
R
P
Q
E
-------------
L
D
E
A
A
R
R
R
F
Q
K
R
L
Y
I
A
L
P
E
P
E
S
R
T
Q
I
V
Q
N
---
L
L
V
G
--
T
R
H
D
I
T
N
H
N
L
E
R
I
R
E
L
T
D
G
Y
S
G
A
D
M
R
Q
L
C
T
E
A
A
M
G
P
I
R
D
I
G
D
D
I
E
T
I
D
K
D
D
I
R
A
V
T
V
M
D
F
A
E
A
A
R
V
V
R
P
-
T
V
D
D
S
-
Q
L
D
A
Y
---
A
---------------
A
W
D
----------------------------------------------------------------------
7
PsiBlast_PDB
75.45
24%
-47
- C3 -
4L15
-
FIGL1_CAEEL
A:
[320-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
E
G
A
K
K
A
L
R
E
I
---
V
V
L
P
F
K
R
P
D
V
F
T
G
I
R
A
P
P
K
G
V
L
L
F
G
P
P
G
T
G
K
T
M
I
G
R
C
V
A
S
Q
--
C
K
A
T
F
F
------
N
I
S
A
S
S
L
T
S
K
W
V
G
E
G
E
K
L
V
R
A
L
F
S
V
A
R
L
K
L
P
S
V
I
F
I
D
E
I
D
S
L
L
S
S
-----
H
E
S
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
V
---
N
TAPD
E
R
L
L
V
L
G
-----
A
T
N
R
P
Q
E
-------------
L
D
E
A
A
R
R
R
F
Q
K
R
L
Y
I
A
L
P
E
P
E
S
R
T
Q
I
V
Q
N
---
L
L
V
G
--
T
R
H
D
I
T
N
H
N
L
E
R
I
R
E
L
T
D
G
Y
S
G
A
D
M
R
Q
L
C
T
E
A
A
M
G
P
I
R
D
I
G
D
D
I
E
T
I
D
K
D
D
I
R
A
V
T
V
M
D
F
A
E
A
A
R
V
V
R
P
-
T
V
D
D
S
-
Q
L
D
A
Y
---
A
---------------
A
W
D
----------------------------------------------------------------------
79
HHSearch
73.71
18%
-50
* C3 *
3EIE
2
VPS4_YEAST
A:
[13-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
V
K
W
E
D
V
A
G
L
E
G
A
K
E
A
L
K
E
A
V
I
L
P
V
---
K
F
P
H
L
F
K
G
N
R
K
P
T
S
G
I
L
L
Y
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
E
A
--------
N
S
T
F
F
S
V
S
S
S
D
L
V
S
K
W
M
G
E
S
E
K
L
V
K
Q
L
F
A
M
A
R
E
N
K
P
S
I
I
F
I
D
Q
V
D
A
L
T
G
T
------
E
A
S
R
R
I
K
T
E
L
L
V
Q
M
N
G
V
GND
S
----
Q
G
V
L
V
L
G
A
T
N
I
P
W
Q
------------------
L
D
S
A
I
R
R
R
F
E
R
R
I
Y
I
P
L
P
D
L
A
A
R
T
T
M
F
E
----
I
N
V
G
--
D
T
P
C
V
L
T
K
E
D
Y
R
T
--
L
G
A
M
T
E
G
Y
S
-----------------------------
G
S
D
I
A
V
V
V
K
D
A
L
M
Q
P
I
R
K
I
Q
S
A
-
T
H
F
K
D
V
S--------------------E
T
R
K
L
T
----------------
P
C
S
PGDDG
A
I
E
M
S
W
T
D
I
EA
D
--
E
L
K
E
P
D
L
T
I
K
D
F
L
K
A
I
K
S
T
R
P
T
V
N
E
-
72
HHSearch
72.95
19%
-41
- C3 -
1XWI
2
VPS4B_HUMAN
A:
[7-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
V
K
W
S
D
V
A
G
L
E
G
A
K
E
A
L
K
E
A
V
I
L
P
I
---
K
F
P
H
L
F
T
G
K
R
T
P
W
R
G
I
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
E
A
-
N
------
N
S
T
F
F
S
I
S
S
S
D
L
V
S
K
W
L
G
E
S
E
K
L
V
K
N
L
F
Q
L
A
R
E
N
K
P
S
I
I
F
I
D
E
I
D
S
L
C
G
S
R
S
E
N
E
S
E
A
A
R
R
I
K
T
E
F
L
V
Q
M
Q
G
V
GVD
N
----
D
G
I
L
V
L
G
A
T
N
I
P
W
V
------------------
L
D
S
A
I
R
R
R
F
E
K
R
I
Y
I
P
L
P
E
P
H
A
R
A
A
M
F
K
----
L
H
L
G
--
T
T
Q
N
S
L
T
E
A
D
F
R
E
--
L
G
R
K
T
D
G
Y
-----------------------------
S
G
A
D
I
S
I
I
V
R
D
A
L
M
Q
P
V
R
K
V
Q
S
A
T
H
F
K
K
V
R
--
G
---------------
P
S
R
ADPN
H
L
V
D
D
L
L
T
P
C
S
PGDPGA
I
E
----------
M
T
W
M
D
V
--
P
GD
K
L
L
E
P
V
V
S
M
S
D
M
L
R
S
L
S
N
T
K
P
T
V
N
--
76
HHSearch
65.97
18%
-29
- C3 -
2ZAN
2
VPS4B_MOUSE
A:
[129-427]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
V
K
W
S
D
V
A
G
L
E
G
A
K
E
A
L
K
E
A
V
I
L
P
I
K
---
F
P
H
L
F
T
G
K
R
T
P
W
R
G
I
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
E
A
-
N
------
N
S
T
F
F
S
I
S
S
S
---------
S
E
K
L
V
K
N
L
F
Q
L
A
R
E
N
K
P
S
I
I
F
I
D
E
I
D
S
L
C
G
S
R
S
E
N
E
S
E
A
A
R
R
I
K
T
E
F
L
V
Q
M
Q
G
V
GVD
N
----
D
G
I
L
V
L
G
A
T
N
I
P
W
V
L
------------------
D
S
A
I
R
R
R
F
E
K
R
I
Y
I
P
L
P
E
A
H
A
R
A
A
M
F
R
----
L
H
L
G
--
S
T
Q
N
S
L
T
E
A
D
F
Q
E
--
L
G
R
K
T
D
G
Y
-----------------------------
S
G
A
D
I
S
I
I
V
R
D
A
L
M
Q
P
V
R
K
V
Q
S
A
T
H
F
K
K
V
R
G
P
S
RADPNCIVN
D
L
L
T
P
C
S
P
G
----------------------
D
PG
A
I
E
-----
M
T
W
M
D
V
--
P
GD
K
L
L
E
P
V
V
S
M
W
D
M
L
R
S
L
S
S
T
K
P
T
V
N
E
-
16
PsiBlast_PDB
61.94
25%
-52
- C3 -
1IN4
1
RUVB_THEMA
A:
[24-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
-------
A
L
E
A
A
K
M
R
G
E
V
---
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
N
I
H
V
T
S
G
P
V
L
V
K
Q
G
D
-------
M
A
A
I
L
T
S
L
E
R
---------
G
D
V
L
F
I
D
E
I
H
R
L
N
K
-----------
A
V
E
E
L
L
Y
S
A
I
E
D
F
---
Q
----
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
TRSGL
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
D
V
--
E
I
E
D
A
A
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
61.76
25%
-54
- C3 -
1IN8
1
RUVB_THEMA
A:
[24-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
-------
A
L
E
A
A
K
M
R
G
E
V
---
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
N
I
H
V
T
S
G
P
V
L
V
K
Q
G
D
-------
M
A
A
I
L
T
S
L
E
R
---------
G
D
V
L
F
I
D
E
I
H
R
L
N
K
-----------
A
V
E
E
L
L
Y
S
A
I
E
D
F
---
Q
----
I
D
---------------
I
Q
P
F
T
L
V
G
A
T
VRSGL
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
D
V
--
E
I
E
D
A
A
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.18
25%
-53
- C3 -
1IN5
1
RUVB_THEMA
A:
[24-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
E
F
I
G
Q
E
N
V
K
K
K
L
S
L
-------
A
L
E
A
A
K
M
R
G
E
V
---
L
D
H
V
L
L
A
G
P
P
G
L
G
K
T
T
L
A
H
I
I
A
S
E
L
Q
T
N
I
H
V
T
S
G
P
V
L
V
K
Q
G
D
-------
M
A
A
I
L
T
S
L
E
R
---------
G
D
V
L
F
I
D
E
I
H
R
L
N
K
-----------
A
V
E
E
L
L
Y
S
A
I
E
D
F
---
Q
----
I
D
I
M
------------
D
I
Q
P
F
T
L
V
G
S
T
TRSGL
L
S
S
P
L
R
S
R
F
G
I
I
L
E
L
D
F
Y
T
V
K
E
L
K
E
I
I
K
R
A
A
S
L
M
D
V
--
E
I
E
D
A
A
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------