@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2326c: (2016-05-09 )
MCCAVCGPEPGRIGEVTPLGPCPAQHRGGPLRPSELAQASVMAALCAVTAIISVVVPFAAGLALLGTVPTGLLAYRYRLRVLAAATVAAGMIAFLIAGLGGFMGVVHSAYIGGLTGIVKRRGRGTPTVVVSSLIGGFVFGAAMVGMLAAMVRLRHLIFKVMTANVDGIAATLARMHMQGAAADVKRYFAEGLQYWPWVLLGYFNIGIMIVSLIGWWALSRLLERMRGIPDVHKLDPPPGDDVDALIGPVPVRLDKVRFRYPRAGQDALREVSLDVRAGEHLAIIGANGSGKTTLMLILAGRAPTSGTVDRPGTVGLGKLGGTAVVLQHPESQVLGTRVADDVVWGLPLGTTADVGRLLSEVGLEALAERDTGSLSGGELQRLALAAALAREPAMLIADEVTTMVDQQGRDALLAVLSGLTQRHRTALVHITHYDNEADSADRTLSLSDSPDNTDMVHTAAMPAPVIGVDQPQHAPALELVGVGHEYASGTPWAKTALRDINFVVEQGDGVLIHGGNGSGKSTLAWIMAGLTIPTTGACLLDGRPTHEQVGAVALSFQAARLQLMRSRVDLEVASAAGFSASEQDRVAAALTVVGLDPALGARRIDQLSGGQMRRVVLAGLLARAPRALILDEPLAGLDAASQRGLLRLLEDLRRARGLTVVVVSHDFAGMEELCPRTLHLRDGVLESAAASEAGGMS
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210----.......220.......230.......-240.......250.......260.-----......270...-....280.......290.......300....--....--310----------....----------.------..------------.320..--.......330-.-.---......340-.....--..-------------------..350---------------.........360---....-----------....370.......380.......390-........400.......410.......420.......430......-.-440....------...450--------.---.---.------------.---------------.------------.----------------------------------------------------------.------------------------------------------------------460-----------.-----.----.---------------.----.----------------------------------------------------------------.-------------------------------------------------------------------------------------------.---.-------------------------------------------------.-------470---------------------------.......480----------------.........490........500...-----..-----..510.......520....-...530.----......540-----------.----.----------...----------..------------..550..-------.....560----------------------------------------------------------------..-----------------------------------------------------.....570..---...--------------------------------------.-.-.-580..-..----....--.590.----------...-..----------.-600.......610.......620...---....630.......640.......650.......660.......670.......680----..--.......-----690.....--------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MCCAVCGPEPGRIGEVTPLGPCPAQHRGGPL
R
P
S
E
L
A
Q
A
S
V
M
A
A
L
C
A
V
T
A
I
I
S
V
V
V
P
F
A
A
G
L
A
L
L
GTV
P
T
G
L
L
A
Y
R
Y
R
L
R
V
L
A
A
A
T
V
A
A
G
M
I
A
F
L
I
A
G
L
G
G
F
M
G
V
V
H
S
A
Y
I
G
G
L
T
G
I
V
K
RRGRG
T
P
T
V
V
V
S
S
L
I
G
G
F
V
F
G
A
A
M
V
G
M
L
A
A
M
V
R
L
R
H
L
I
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K
V
M
TANV
D
G
I
A
A
T
L
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M
H
MQG
A
A
A
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K
R
Y
F
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G
L
Q
Y
W
P
W
V
L
L
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N
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L
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I
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W
W
A
L
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L
L
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M
RGIP
D
V
HKLDPPPG-DD
V
D
A
LIGPVP
V
R
L
D
K
V
R
F
RYPRA-----
G
Q
D
A
L
R
E
V
S
L
D
V-RAG
E
H
L
A
I
I
GANGSG
K
T
T
L
M
L
I
L
AGR-APTS--GTVD--RP-----------GTVG----------L------GK------------LG--
G
T
--
A
V
V
L
QHPES--Q-V---LG
T
R
VAD---D
V
V
WG--LP-------------------LG
T
-----------------
T
A
D
V
G
R
L
L
S
E
V
----
G
L
E
A
-----------
L
A
ERDTGSLSG
G
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Q
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L
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L
A
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P
A
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L
I
A
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T
T
M
V
DQQG
R
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A
L
L
A
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L
S
G
L
T
Q
R
H
R
T
A
L
V
H
I
T
HYDNEAD-S-AD
R
T
L
SL------SDSPDN--------T---D---
M
------------
V
---------------H------------T----------------------------------------------------------A------------------------------------------------------A-------------M-----P----A---------------P----V----------------------------------------------------------------I-------------------------------------------------------------------------------------------G---V-------------------------------------------------D-------QPQ---------------------------HAP
A
L
E
L
V
------------------GVGHEYASGT-P
W
A
K
T
A
LR
D
I
N
F
V
V
E-----QG-----
D
G
V
L
I
HGGNGSG
K
S
T
L
A
W
I
-
M
AGLTIP----TT
G
A
C
LL-------------D----G----------RP
T
----------
H
E
------------
Q
VG
A
V
A
L
-------
S
F
Q
A
A
R
L
Q
----------------------------------------------------------------
L
M
-----------------------------------------------------
R
S
RV
D
L
E
-
V
A---SAA--------------------------------------G-F-S-A--
S
E
-
Q
D
----
R
V
A
A
--
A
L
T
V
V
----------GLD-P
A
----------
L
-
G
A
R
R
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D
Q
LSGG
Q
M
R
R
V
V
L
A
G
L
L
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RAP---
R
A
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LDEPLAGL
D
A
A
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L
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RAR
G
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VSHDFA
G
M
E
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LCPRT
L
H
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------
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--
G
V
L
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AA-----ASEAGGMS--------------------------------------------------
58
HHSearch
84.90
22%
-87
- C1 -
4F4C
2
PGP1_CAEEL
A:
[385-1301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
G
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DIN
L
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--
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---
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N
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---
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--
K
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-------------------
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-----------------
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A
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K
M
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----
N
A
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L
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D
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------
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N
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M
---
A
---
Q
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L
Y
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GER
I
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NNAQKTN
L
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AGNPADFL
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QHIGFF
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-------------
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----
N
A--------------
S
----
G
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M
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TLGFAT
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A
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L
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KISKI
D
SLSLAGE
K
K
K
---------------------------
L
Y
G
K
V
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F
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------------------
N
V
R
F
A
Y
P
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---
P
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L
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-----
P
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-----
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Q
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P
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------------------------------------------------------------------
F
-----------------------------------------------------
D
C
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A
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N
-
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---
Y
G
L
--------------------------------------
D
-
P
-
S
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S
--
V
T
-
M
A
----
Q
V
E
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--
A
A
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L
A
----------
N
I
H
-
N
F
I
A
E
LPEGFET
R
-
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
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V
R
N
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---
K
I
L
L
L
D
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A
T
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A
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V
V
Q
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A
L
D
R
A
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M
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------
S
N
--
G
T
I
I
E
K
G
-----
T
H
T
Q
------------------------------------------------------
51
Fugue
72.50
19%
-76
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
-----
M
S
D
K
N
S
R
I
A
I
V
S
A
D
K
C
K
P
K
K
C
R
------------
Q
E
C
K
R
S
C
P
V
V
K
T
-------------------------------------------------------------
G
K
L
C
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S
K
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A
F
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S
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I
L
C
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--------
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N
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--------------
H
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R
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---
S
A
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---------------
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----------------------------------------------------------------
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---
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-------
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N
L
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FRT
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A
L
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RIADATEDLQ
N
D
S
A
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-
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----
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----------
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------------
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A
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-------
K
F
P
G
T
V
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Q
----------------------------------------------------------------
L
F
-----------------------------------------------------
F
K
K
I
---------
R
G
Q
--------------------------------------
F
-
L
-
N
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--
Q
F
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----
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----------
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-
I
D
Q
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Q
H
L
S
G
G
E
L
Q
R
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A
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A
L
G
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P
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---
D
I
Y
L
I
D
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P
S
A
Y
L
D
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R
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I
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S
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F
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L
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N
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K
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--
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P
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K
N
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-----
A
R
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L
L
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C
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F
L
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NVTFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
59
HHSearch
68.60
25%
-86
- C1 -
4FIN
13
ETTA_ECOLI
A:
[4-518]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
Y
T
M
H
R
V
G
K
V
V
P
P
K
------
R
H
I
L
K
N
I
S
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-
F
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A
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-----------
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D
----------------------------------
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A
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----
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L
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L
D
A
E
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
-
A
G
W
I
L
E
L
------
D
R
G
E
G
I
--------
P
W
E
G
N
---
Y
------------
S
---------------
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
----------------------------------------------------------
S
Q
E
A
A
R
R
------------------------------------------------
K
S
I
E
K
E
L
E
W
-----
V
-----
R
QGTK-KGKARLAR
F
E
E
L
N
S
T
E
----
Y
----------------------------------------------------------------
Q
K
R
N
E
TNE
L
F
I
---------------------------------------------------------------------------------
P
---
P
-------------------------------------------------
G
-------
P
R
L
---------------------------
G
D
K
V
L
E
V
S
------------------
N
L
R
K
S
Y
G
D
------
R
L
L
I
D
D
L
S
F
S
I
P
-----
K
G
-----
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
-
I
S
G
Q
E
Q
P
----
D
S
G
T
I
T
L
-------------
G
----
E
----------
T
V
----------------------------
K
L
A
S
-------
V
D
Q
F
R
D
S
M
----------------------------------------------------------------
D
N
-----------------------------------------------------
S
K
T
V
W
E
E
-
V
S
---
G
G
L
--------------------------------------
D
-
I
-
M
-
K
IG
N
T
-
E
M
----
P
S
R
A
--
Y
V
G
R
F
----------
N
F
K
-
G
V
----------
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
------
Q
D
--
E
G
--------------------------------------------------------------------
3
PsiBlast_PDB
68.11
38%
-113
- C1 -
2YZ2
-
ECFA2_THEMA
A:
[3-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
V
------------------
N
V
S
H
I
F
H
R
G
T
-
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
-----
E
G
-----
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
-
V
A
G
L
I
E
P
----
T
S
G
D
V
L
Y
-------------
D
----
G
E
R
--------
K
K
G
----------
Y
E
------------
I
R
R
N
I
G
I
-------
A
F
Q
Y
P
E
D
Q
----------------------------------------------------------------
F
F
-----------------------------------------------------
A
E
R
V
F
D
E
-
V
A
---
F
A
V
--------------------------------------
K
-
N
-
F
-
Y
--
P
D
-
R
D
P
V
P
-
L
V
K
K
--
A
M
E
F
V
----------
G
L
D
F
D
S
----------
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
------
E
K
--
G
---------------------------------------------------------------------
60
HHSearch
67.31
24%
-105
- C- -
2IW3
7
EF3A_YEAST
A:
[432-979]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
E
D
L
C
N
C
E
F
S
L
A
Y
G
-----
A
K
I
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
--------
Q
V
----
D
-----------
G
F
P
-----------
T
------
Q
E
------------
E
C
--
R
T
--
V
Y
V
E
H
D
I
D
G
--
T
-
H
---
S
D
T
S
V
L
D
---
F
V
F
E
S
--
G
V
--------------------
G
T
-----------------
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
E
----------
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
--
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
-
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
--------
K
---
Y
K
G
N
F
------------
T
---------------
E
------------
F
V
K
K
C
PA----------------------------------------------------
A
------------------------------------------------------
K
AYEELSN
T
D
L
E
F
K
F
-----
P
----
E
---------------
P
----
G
----------------------------------------------------------------
Y
L------------------------------------------------------------------------------------------
E
---
G
-------------------------------------------------
V
-------
K
T
K
---------------------------
Q
K
A
I
V
K
V
T
------------------
N
M
E
F
Q
Y
P
G
T
----
S
K
P
Q
I
T
D
I
N
F
Q
C
S
-----
L
S
-----
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
-
L
T
G
E
L
L
P
----
T
S
G
E
V
Y
T
-------------
H
----
E
----------
N
C
----------------------------
R
I
A
Y
-------
I
K
Q
H
A
F
A
H
IESHLDKT
P
S
E
Y
I
Q
W
R
------------------------------------------------
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
-
I
G
---
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
G
Q
F
-
R
-
P
--
L
T
-
R
K
----
E
I
E
E
--
H
C
S
M
L
----------
G
L
D
-
P
E
----------
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
------
K
D
--
G
R
M
T
P
S
----------------------------------------------------------------
63
HHSearch
64.34
24%
-75
- C1 -
1YQT
4
?
A:
[24-480]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
E
D
C
V
H
R
Y
G
V
N
------
A
F
V
L
Y
R
L
P
-
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
CG
D
N
D
S
--
W
D
-----------
G
V
I
R
A
F
RGNE----
L
------
Q
N
Y
F
E
K
L
K
------
N
G
--
E
I
R
P
V
V
K
P
Q
Y
V
D
---
L
-
I
---
P
K
A
V
K
G
K
---
V
I
E
L
L
--
K
K
-------------------
A
D
E
-----------------
T
G
K
L
E
E
V
V
K
A
L
----
E
L
E
N
-----------
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
-
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
-
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
G
V
Y
G
------
I
---
F
S
--
Q
------------
P
---------------
K
G
T
R
N
G
-------
I
----------------------------------------------------------
N
E
F
L
---------------------------------------------------
R
GYLKDENVRF---
R
-----
P
----
Y
---------------
E
----
I
----------------------------------------------------------------
K
-------------------------------------------------------------------------------------------
F
---
T
KTGER--------------------------------------------
V
-------
E
I
E
---------------------------
R
E
T
L
V
T
Y
P
------------------
R
L
V
K
D
Y
G
S
-------
F
R
L
E
V
E
P
G
E
I
K
-----
K
G
-----
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
-
L
A
G
V
E
E
P
----
T
E
G
K
I
E
W
-------------
D
----
L
----------------------------------------
T
V
A
Y
-------
K
P
Q
Y
I
K
A
-----------------------------------------------------------------
D
Y
-----------------------------------------------------
E
G
T
V
Y
E
L
-
L
S
---
K
I
D
--------------------------------------
A
-
S
-
K
-
L
--
N
S
-
N
F
----
Y
K
T
E
--
L
L
K
P
L
----------
G
I
I
-
D
-----------
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
------
E
G
--
E
P
G
-------------------------------------------------------------------
21
PsiBlast_CBE
64.11
38%
-99
- C1 -
4HLU
3
ECFA2_THEMA
B:
[5-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
V
------------------
N
V
S
H
I
F
H
R
G
T
-
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
-----
E
G
-----
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
-
V
A
G
L
I
E
P
----
T
S
G
D
V
L
Y
-------------
D
----
G
ER--------
K
K
G
----------
Y
E
------------
I
R
R
N
I
G
I
-------
A
F
Q
Y
P
E
D
Q
----------------------------------------------------------------
F
F
-----------------------------------------------------
A
E
R
V
F
D
E
-
V
A
---
F
A
V
--------------------------------------
K
-
N
-
F
-
Y
--
P
D
-
R
D
PVP-
L
V
K
K
--
A
M
E
F
V
----------
G
L
D
F
D
S
----------
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
------
E
K
--
G
---------------------------------------------------------------------
5
PsiBlast_PDB
64.00
38%
-99
- C1 -
4HLU
2
ECFA2_THEMA
A:
[5-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
V
------------------
N
V
S
H
I
F
H
R
G
T
-
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
-----
E
G
-----
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
-
V
A
G
L
I
E
P
----
T
S
G
D
V
L
Y
-------------
D
----
G
E
R
--------
K
K
G
----------
Y
E
------------
I
R
R
N
I
G
I
-------
A
F
Q
Y
P
E
D
Q
----------------------------------------------------------------
F
F
-----------------------------------------------------
A
E
R
V
F
D
E
-
V
A
---
F
A
V
--------------------------------------
K
-
N
-
F
-
Y
--
P
D
-
R
D
P
V
P
-
L
V
K
K
--
A
M
E
F
V
----------
G
L
D
F
D
S
----------
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
------
E
K
--
G
---------------------------------------------------------------------
6
PsiBlast_PDB
62.84
33%
-100
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
------------------
N
V
S
F
I
Y
N
E
G
T
-
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
-----
D
E
-----
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
-
L
N
G
L
L
K
P
----
S
K
G
K
I
Y
I
-------------
N
----
G
IDITDKKVS
L
K
D
I
----------
R
K
------------
Q
V
G
L
V
----------
F
Q
Y
P
E
Y
Q
----------------------------------------------------------------
L
F
-----------------------------------------------------
E
E
T
V
F
K
D
-
I
A
F
G
P
S
N
L
--------------------------------------
G
-
L
-
S
-
E
--
E
E
V
K
E
----
R
V
Y
E
--
A
M
E
I
V
----------
G
I
S
-
K
E
----------
L
-
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
---
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
------
N
R
--
G
K
I
E
------------------------------------------------------------------
64
HHSearch
62.31
20%
-81
- C1 -
3OZX
5
?
A:
[4-464]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
H
R
Y
K
V
N
------
G
F
K
L
F
G
L
P
T
-
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
F
--
G
D
P
N
--
S
K
VG
K
D
E
V
L
K
R
F
R
G
K
E
-----------
I
------
Y
N
Y
F
K
E
L
Y
S
NE
L
K
I
V
H
--
K
I
--
Q
Y
V
E
Y
A
S
----
K
-
F
---
L
K
G
T
V
N
E
---
I
L
T
K
I
--
D
----------------------
E
-----------------
R
G
K
K
D
E
V
K
E
L
L
----
N
M
T
N
-----------
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
--
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
--
K
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
-
Y
L
T
D
L
I
H
I
I
-------
Y
G
E
S
S
--------
V
---
Y
G
R
-
V
------------
S
---------------
K
SYA
A
R
-------
V
G
I
--------------------------------------------------------
N
N
F
L
---------------------------------------------------
K
-------------
G
-----
Y
----
L
---------------
P
----
A
----------------------------------------------------------------
E
-------------------------------------------------------------------------------------------
N
MKI
R
-------------------------------------------------
P
-------
D
E
I
---------------------------
K
F
M
L
K
---LKTK
M
K
W
T
----------
K
I
I
K
K
L
G
D
-------
F
Q
L
V
V
D
N
G
E
A
K
-----
E
G
-----
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
-
L
V
G
E
I
T
A
----
D
E
G
S
V
T
P
-------------
E
----
K
----------
Q
-----------------------------
I
L
S
Y
-------
K
P
Q
R
I
F
P
-----------------------------------------------------------------
N
Y
-----------------------------------------------------
D
G
T
V
Q
Q
Y
-
L
E
---
N
A
S
--------------------------------------
K
-
D
-
A
L
S
--
T
S
-
S
W
----
F
F
E
E
--
V
T
K
R
L
----------
N
L
H
-
R
-----------
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
V
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
------
K
G
--
E
P
E
-------------------------------------------------------------------
17
PsiBlast_PDB
62.08
25%
-77
- C1 -
1YQT
4
?
A:
[44-471]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
-
L
I
P
N
--
L
C
G
D
--
N
D
-----------
S
W
D
G
----------
V
I
R
A
F
RG
N
E
------------
L
Q
--
N
Y
--
F
E
K
L
K
N
G
E
I
--
R
P
V
---
V
K
P
Q
Y
V
D
LIP
K
A
V
K
G
K
V
I
E
-------------------
L
L
K
-----------------
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
-----------
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
-------------
V
E
H
D
L
A
V
------
L
D
Y
L
----------
S
---
D
---
I
------------
I
---------------
H
------------
V
----------------------------------------------------------
V
------------------------------------------------------
Y
-------------
G
-----
E
----
P
---------------
G
----
V
----------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------
G
---
I
F
------------------------------------------------
S
-------
Q
P
K
G
T
R
N
G
I
N
E
F
L
R
GYLKDENVRFRP
Y
E
I
K
F
T
K
T
G
E
R
V
------------------
E
I
E
R
E
T
L
V
T
Y
-
P
R
L
V
K
D
Y
G
S
F
R
L
E
V
E
P
G
E
I
K
K
G
-----
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
-
L
A
G
V
E
E
P
----
T
E
G
K
I
E
W
-------------
D
L
T
V
A
Y
----------
K
P
Q
----------
Y
-----------------
I
K
A
-------
D
Y
E
G
T
V
Y
E
----------------------------------------------------------------
L
L
------------------------------------------------------
S
K
I
D
A
S
-
K
L
---
N
S
---------------------------------------
N
-
F
-
Y
-
K
--
T
E
--------
L
L
K
--
P
L
G
I
I
----------
D
L
----------------
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
------------------------------------------------------------------------------------
22
PsiBlast_CBE
62.00
33%
-102
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
------------------
N
V
S
F
I
Y
N
E
G
T
-
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
-----
D
E
-----
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
-
L
N
G
L
L
K
P
----
S
K
G
K
I
Y
I
-------------
N
----
G
IDITDKKVS
L
K
D
I
----------
R
K
------------
Q
V
G
L
V
----------
F
Q
Y
P
E
Y
Q
----------------------------------------------------------------
L
F
-----------------------------------------------------
E
E
T
V
F
K
D
-
I
A
F
G
P
S
N
L
--------------------------------------
G
-
L
-
S
-
E
--
E
E
V
K
E
----
R
V
Y
E
--
A
M
E
I
V
----------
G
I
S
-
K
E
----------
L
-
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
---
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
------
N
R
--
G
K
I
E
------------------------------------------------------------------
62
HHSearch
61.23
25%
-78
- C1 -
3BK7
4
?
A:
[82-547]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
I
S
I
V
N
L
P
E
Q
L
D
E
D
CVHRY
G
V
N
A
F
V
L
Y
R
L
P
I
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
N
DS
W
D
N
V
I
R
A
F
R----
G
N
E
-----------
L
------
Q
N
Y
F
E
R
L
K
------
N
G
E
I
R
P
--
V
V
K
P
Q
Y
V
D
L
L
P
K
-
A
---
V
K
G
K
V
R
E
---
L
L
K
K
------------------------
V
D
E
-----------------
V
G
K
F
E
E
V
V
K
E
L
----
E
L
E
N
-----------
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
--
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
-
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
V
I
H
V
V
------
Y
G
E
P
G
V
Y
G
I
F
S
---
K
---
P
---
K
G-----------
T
---------------
R
------------
N
G
I
--------------------------------------------------------
N
E
F
L
---------------------------------------------------
Q
GYLKD--------
E
NVRFR
P
----
Y
---------------
E
I
R
F
T
K
L---------------------------------------------------------------
S
-------------------------------------------------------------------------------------------
E
---
R
-------------------------------------------------
V
-------
D
V
E
---------------------------
R
E
T
L
V
E
Y
P
------------------
R
L
V
K
D
Y
G
S
-------
F
K
L
E
V
E
P
G
E
I
R
-----
K
G
-----
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
-
L
A
G
V
E
E
P
----
T
E
G
K
V
E
W
-------------
D
----
L
----------------------------------------
T
V
A
Y
-------
K
P
Q
Y
I
K
A
-----------------------------------------------------------------
E
Y
-----------------------------------------------------
E
G
T
V
Y
E
L
-
L
S
---
K
I
D
--------------------------------------
S
-
S
-
K
-
L
--
N
S
-
N
F
----
Y
K
T
E
--
L
L
K
P
L
----------
G
I
I
-
D
-----------
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
------
E
G
------------------------------------------------------------------------
67
HHSearch
59.57
27%
-66
- C1 -
2VF7
3
?
A:
[362-824]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
H
L
----
G
L
G
Y
L----------
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
LF
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
-
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
PEAGE
K
G
G
E
I
L
--------
Y
---
S
---
G
PP----------
E
---------------
G
------------
L
----------------------------------------------------------
K
HVP---------------------------------------------------
E
-------------
S
-----
Q
----
T
G
Q
Y
L
-----------
F
----
A
DRHT------------------------------------------------------------
E
-------------------------------------------------------------------------------------------
P
---
H
-------------------------------------------------
T
-------
P
R
E
---------------------------
P
A
G
W
L
E
L
N
------------------
G
V
T
-----------
R
N
N
L
D
N
L
D
V
R
F
P
-----
L
G
-----
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ--
G
S
A
R
L
G
G
DLAQIT
R
L
V
R
V
D
----
Q
----------
K
P
I
----------
G
R
TPRSN-------
M
A
T
Y
T
G
L
-------
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
GYNAGRFSFNVKGGRCEHCQGEGWVMVELLFL
P
S
V
Y
A
P
CPVCHGTRYN
A
E
T
L
E
VE
Y
R
-----------------------------------------------------
G
K
N
I
A
D
V
-
L
A
---
L
T
V
D
E
A
H
----------------------------------
D
-
F
F
A
-
D
E-
S
A
-
I
F
----
R
A
L
D
--
T
L
R
E
V
----------
G
L
G
-
Y
L
----------
R
-
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
RGG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
PGAGE
D
G
--
G
R
L
V
A
Q
G
-----
T
P
A
E
------------------------------------------------------
61
HHSearch
59.50
21%
-66
- C1 -
3J16
2
RLI1_YEAST
B:
[81-552]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
V
T
H
R
Y
S
A
N
------
S
F
K
L
H
R
L
P
-
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
--
D
P
-----------
P
E
W
Q
E
I
I
K
Y
F
RGSE
L
------
Q
N
Y
F
T
K
M
L
------
E
D
--
D
I
K
A
I
I
K
P
Q
Y
V
D
N
I
P
R
-
A
I
KG
P
V
Q
K
V
G
E
---
L
L
K
L
R
--
M
E
--------------------
K
S
-----------------
P
E
D
V
K
R
Y
I
K
I
L
----
Q
L
E
N
-----------
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
-
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
-
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
Y
G
V
V
T
---
L
---
P
A--
S
------------
V
---------------
R
------------
E
G
I
N
I
F
-----------------------------------------------------
L
------------------------------------------------------
D
-------------
G
-----
H
----
I
---------------
P
----
A
----------------------------------------------------------------
E
NLRFRT
E
A
L
Q
F
--------------------------------------------------------------------------------
R
---
I
-------------------------------------------------
A
-------
D
A
T
---------------------------
E
D
L
Q
N
D
S
A
------------------
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
F
S
-----
D
S
-----
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
-
L
A
G
A
L
K
P
----
D
E
G
Q
D
I
P
---------------------------------------------------------
K
L
N
V
S
M
-------
K
P
Q
K
I
A
P
K
-----------------------------------------------------------------
F
-----------------------------------------------------
P
G
T
V
R
Q
L
-
F
F
---
K
K
I
--------------------------------------
R
-
G
-
Q
-
F
--
L
N
-
P
Q
----
F
Q
T
D
--
V
V
K
P
L
----------
R
I
D
-
D
-----------
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
------
E
G
I
P
S
K
N
A
H
A
R
---------------------------------------------------------------
4
PsiBlast_PDB
59.10
38%
-96
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[4-215]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
V
------------------
N
V
S
H
I
F
H
R
G
T
-
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
-----
E
G
-----
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
-
V
A
G
L
I
E
P
----
T
S
G
D
V
L
Y
-------------
D
----
G
E----------
K
G
----------
Y
E
------------
I
R
R
N
I
G
I
-------
A
F
Q
Y
P
E
D
Q
----------------------------------------------------------------
F
F
-----------------------------------------------------
A
E
R
V
F
D
E
-
V
A
---
F
A
V
--------------------------------------
K
-
N
-
F
-
Y
--
P
D
-
R
D
P
V
P
-
L
V
K
K
--
A
M
E
F
V
----------
G
L
D
F
D
S
----------
F
-
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
---
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
------
E
K
--
G
---------------------------------------------------------------------
9
PsiBlast_PDB
57.64
31%
-108
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
E
------------------
E
L
N
Y
N
Y
S
D
G
T
-----
H
A
L
K
G
I
N
M
N
I
K
-----
R
G
-----
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
-
F
N
G
I
L
K
P
----
S
S
G
R
I
L
F
-------------
D
----
N
----------
K
P
I
DYS
R
K
G
I
M
K
L
R
E
------------
S
I
G
I
V
----------
F
Q
D
P
D
N
Q
----------------------------------------------------------------
L
F
-----------------------------------------------------
S
A
S
V
Y
Q
D
-
V
S
---
F
G
A
--------------------------------------
V
-
N
-
M
-
K
--
L
P
-
E
D
E
I
R
K
R
V
D
N
--
A
L
K
R
T
----------
G
I
E
--
H
----------
L
-
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
---
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
------
K
E
--
G
---------------------------------------------------------------------
10
PsiBlast_PDB
57.09
30%
-105
- C1 -
1L2T
4
Y796_METJA
A:
[2-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
------------------
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
-----
E
G
-----
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
-
I
G
C
L
D
K
P
----
T
E
G
E
V
Y
I
-------------
D
----
N
----------
I
K
T
----------
N
D
LD
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
----------------------------------------------------------------
T
A
-----------------------------------------------------
L
E
N
V
E
L
P
L
I
F
---
K
Y
R
--------------------------------------
G
-
A
-
M
-
S
--
G
E
-
E
R
----
R
K
R
A
L
E
C
L
K
M
A
----------
E
L
E
-
E
R
----------
F
-
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
---
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------
K
D
--
G
E
V
E
------------------------------------------------------------------
12
PsiBlast_PDB
57.00
30%
-100
- C1 -
3TIF
7
Y796_METJA
A:
[2-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
K
------------------
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
-----
E
G
-----
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
-
I
G
C
L
D
K
P
----
T
E
G
E
V
Y
I
-------------
D
----
N
----------
I
K
T
----------
N
D
LD
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
----------------------------------------------------------------
T
A
-----------------------------------------------------
L
E
N
V
E
L
P
L
I
F
---
K
Y
R
--------------------------------------
G
-
A
-
M
-
S
--
G
E
-
E
R
----
R
K
R
A
L
E
C
L
K
M
A
----------
E
L
E
-
E
R
----------
F
-
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
---
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------
K
D
--
G
E
V
E
------------------------------------------------------------------
56
Fugue
56.29
19%
-80
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
--------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
---
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
-----------
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
----
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
-
K
E
V
L
I
F
G
G
----
Q
E
V
E
T
K
R
F
D
K
V
S
-----
N
K
M
R
L
Q
G
M
K
M
V
S
-
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
-
P
S
V
M
--
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
--
P
L
K
S
L
T
N
V
N
A
Q
F
--
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
------------
E
Q
E
K
D
-
E
-
G
K
R
V
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
---------------------------
A
T
G
D
L
E
F
R
------------------
N
V
T
F
T
Y
P
G
R
----
E
V
P
A
L
R
N
I
N
L
K
I
P
-----
A
G
-----
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
-
I
T
R
F
Y
D
I
----
D
E
G
H
I
L
M
-------------
D
----
G
----------
H
D
L
----------
R
E
-------------
Y
T
L
A
S
L
-------
R
N
Q
V
A
L
V
S
Q
N
V
H
------------------------------------------------------------
L
F
-----------------------------------------------------
N
D
T
V
A
N
N
-
I
A
---
Y
A
R
--------------------------------------
T
-
E
-
E
-
Y
--
S
R
-
E
Q
----
I
E
E
A
--
A
R
M
A
Y
A
M
D
F
I
N
K
M
DN
G
L
D
-
T
I
----------
I
-
G
E
N
G
V
-
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
---
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
------
E
D
--
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
QFG------------------------------------------
11
PsiBlast_PDB
54.93
30%
-103
- C1 -
1F3O
2
Y796_METJA
A:
[2-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
------------------
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
-
Y
A
L
K
N
V
N
L
N
I
K
-----
E
G
-----
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
-
I
G
C
L
D
K
P
----
T
E
G
E
V
Y
I
-------------
D
----
N
----------
I
K
T
----------
N
D
LD
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
-------
Q
F
N
L
I
P
L
L
----------------------------------------------------------------
T
A
-----------------------------------------------------
L
E
N
V
E
L
P
L
I
F
---
K
Y
R
--------------------------------------
G
-
A
-
M
-
S
--
G
E
-
E
R
----
R
K
R
A
L
E
C
L
K
M
A
----------
E
L
E
-
E
R
----------
F
-
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
---
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------
K
D
--
G
E
V
E
------------------------------------------------------------------
28
PsiBlast_CBE
45.70
32%
-77
- C1 -
2IXF
4
TAP1_RAT
C:
[35-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
L
T
F
T
L
Y
-----
P
G
-----
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
-
L
Q
N
L
Y
Q
P
----
T
G
G
K
V
L
L
-------------
D
----
G
----------
E
P
L
VQYD
H
H
Y
L
--
H
T
------------
Q
V
A
A
V
G
Q
EPLLFG
R
S
F
R
E
N
I
A
Y
----------------------------------------------------------------
G
L
-----------------------------------------------------
T
R
T
P
T
M
E
-
E
I
---
T
A
V
--------------------------------------
A
-
M
-
E
-
S
--
G
A
-
H
D
----
F
I
S
G
--
F
P
Q
------------
G
Y
D
-
T
E
----------
V
-
G
E
T
G
-
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
---
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
-
L
A
E
R
A
H
H
I
L
F
L
------
K
E
--
G
---------------------------------------------------------------------
32
PsiBlast_CBE
44.67
31%
-74
- C1 -
2IXE
3
TAP1_RAT
A:
[35-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
L
T
F
T
L
Y
-----
P
G
-----
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
-
L
Q
N
L
Y
Q
P
----
T
G
G
K
V
L
L
-------------
D
----
G
----------
E
P
L
VQYD
H
H
Y
L
--
H
T
------------
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
----------------------------------------------------------------
G
L
-----------------------------------------------------
T
R
T
P
T
M
E
-
E
I
---
T
A
V
--------------------------------------
A
-
M
-
E
-
S
--
G
A
-
H
D
----
F
I
S
G
--
F
P
Q
------------
G
Y
D
-
T
E
----------
V
-
G
E
T
G
-
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
---
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
-
L
A
E
R
A
H
H
I
L
F
L
------
K
E
--
G
---------------------------------------------------------------------
27
PsiBlast_CBE
44.54
32%
-77
- C1 -
2IXF
4
D:
[35-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
L
T
F
T
L
Y
-----
P
G
-----
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
-
L
Q
N
L
Y
Q
P
----
T
G
G
K
V
L
L
-------------
D
----
G
----------
E
P
L
VQYDHHYL--
H
T
------------
Q
V
A
A
V
G
Q
LLFGR--
S
F
R
E
N
I
A
Y
----------------------------------------------------------------
G
L
-----------------------------------------------------
T
R
T
P
T
M
E
-
E
I
---
T
A
V
--------------------------------------
A
-
M
-
E
-
S
--
G
A
-
H
D
----
F
I
S
G
--
F
P
Q
------------
G
Y
D
-
T
E
----------
V
-
G
E
T
G
-
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
---
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
-
L
A
E
R
A
H
H
I
L
F
L
------
K
E
--
G
---------------------------------------------------------------------
29
PsiBlast_CBE
44.45
32%
-79
- C1 -
2IXF
4
TAP1_RAT
B:
[35-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
L
T
F
T
L
Y
-----
P
G
-----
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
-
L
Q
N
L
Y
Q
P
----
T
G
G
K
V
L
L
-------------
D
----
G
----------
E
P
L
VQYD
H
H
Y
L
--
H
T
------------
Q
V
A
A
V
G
Q
E
P
L
L
F
GR
S
F
R
E
N
I
A
Y
----------------------------------------------------------------
G
L
-----------------------------------------------------
T
R
T
P
T
M
E
-
E
I
---
T
A
V
--------------------------------------
A
-
M
-
E
-
S
--
G
A
-
H
D
----
F
I
S
G
--
F
P
Q
------------
G
Y
D
-
T
E
----------
V
-
G
E
T
G
-
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
---
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
-
L
A
E
R
A
H
H
I
L
F
L
------
K
E
--
G
---------------------------------------------------------------------
31
PsiBlast_CBE
43.66
31%
-80
- C1 -
2IXE
3
D:
[35-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
L
T
F
T
L
Y
-----
P
G
-----
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
-
L
Q
N
L
Y
Q
P
----
T
G
G
K
V
L
L
-------------
D
----
G
----------
E
P
L
VQYDHHYL--
H
T
------------
Q
V
A
A
V
G
-PLLFGR-
S
F
R
E
N
I
A
Y
----------------------------------------------------------------
G
L
-----------------------------------------------------
T
R
T
P
T
M
E
-
E
I
---
T
A
V
--------------------------------------
A
-
M
-
E
-
S
--
G
A
-
H
D
----
F
I
S
G
--
F
P
Q
------------
G
Y
D
-
T
E
----------
V
-------
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
---
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
-
L
A
E
R
A
H
H
I
L
F
L
------
K
E
--
G
---------------------------------------------------------------------
30
PsiBlast_CBE
43.58
32%
-77
- C1 -
2IXF
5
TAP1_RAT
A:
[35-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
G
L
T
F
T
L
Y
-----
P
G
-----
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
-
L
Q
N
L
Y
Q
P
----
T
G
G
K
V
L
L
-------------
D
----
G
----------
E
P
L
VQYD
H
H
Y
L
--
H
T
------------
Q
V
A
A
V
G
Q
EPLLFGR
S
F
R
E
N
I
A
Y
----------------------------------------------------------------
G
L
-----------------------------------------------------
T
R
T
P
T
M
E
-
E
I
---
T
A
V
--------------------------------------
A
-
M
-
E
-
S
--
G
A
-
H
D
----
F
I
S
G
--
F
P
Q
------------
G
Y
D
-
T
E
----------
V
-
G
E
T
G
-
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
---
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
-
L
A
E
R
A
H
H
I
L
F
L
------
K
E
--
G
---------------------------------------------------------------------