@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2589: (2016-05-12 )
MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVPAEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTERLATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL
Atome Classification :
(41 SA)
.........10........20........30........40----..------....-...50........60........70........80........90........100.......110........120.......130.......140-------.------.......150.......160.......170.......180.......190.......200.......210......--.220.......230........240.......250.......260.......270.......280.......290.......-300........310....-------...320.......330.......340.......350.......360.....-.--.-.370.......380.......390..---.-.....400.......410.......420.......430.......440.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
S
L
Q
Q
S
R
R
L
V
T
EIPG
P
A
S
Q
A
L
T
H
R
R
A
A
AVSSGV
G
V
T
L
P
V
-----
F
V
------ARAG-GG
I
V
EDVDG
N
R
L
I
DLGS
G
I
A
V
T
T
IGNSSP
R
V
V
D
A
V
R
T
Q
V
A
E
F
TH
T
C
F
M
VTPYE
G
Y
V
A
V
A
E
Q
L
N
R-ITPGSGP
K
R
S
V
L
FNS
G
A
E
A
V
E
N
A
V
K
I
A
R
SYT--------G------K
P
A
V
V
A
F
DHAYHGRT
N
L
T
M
A
L
TAKSMPYKSGFGPF
A
P
E
I
Y
RAPLSYPYRDGLL
D
K
Q
LATNGE
L
A
A
A
R
A
I
G
V
I
DKQV--GAN
N
L
A
A
L
V
I
E
P-IQGEG
G
F
I
V
PA
E
G
F
L
P
A
L
L
D
W
C
RKN
H
V
V
F
I
ADEVQTGFART
G
A
M
F
A
C
EHEGPDGLEPD
L
I
C
TAKGIADG-L-PLSAVTG
R
A
E
IMNAPH-------VGGLGGTFGG
N
P
V
A
C
A
A
A
L
A
T
I
ATIESD
G
L
I
E
R
A
R
Q
I
E
R
L
V
T
D
R
L
-
T
T
L
Q
A
-
V
--
D
-
D
R
I
GDVRGRG
A
M
I
A
V
E
L
V
KSGTT-EP---D-A
G
L
T
E
R
L
A
T
A
AHA
A
G
V
I
I
L
T
C
G
M
F
G
N
I
I
R
LLPPLTI
G
D
E
L
L
SE
G
L
D
I
V
C
A
I
L
ADL
1
PsiBlast_PDB
98.19
83%
-104
- C2 -
3R4T
5
?
A:
[24-467]
-
A
S
L
D
Q
S
R
L
L
V
T
E
I
P
G
P
A
S
L
E
L
N
K
R
R
A
A
A
V
S
G
G
V
G
V
T
L
P
V
-----
F
V
------
V
R
A
G
-
G
G
I
V
E
D
A
D
G
N
R
L
I
D
L
G
S
G
I
A
V
T
T
I
G
N
S
A
P
R
V
V
D
A
V
R
D
Q
V
E
Q
F
T
H
T
C
F
M
V
T
P
Y
E
Q
Y
V
A
V
A
E
Q
L
N
R
-
I
T
P
G
S
G
E
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
S
I
K
V
A
R
A
H
T
--------
R
------
K
Q
A
V
V
A
F
D
Y
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
S
M
P
Y
K
S
G
F
G
P
F
A
P
E
I
Y
R
A
P
V
S
Y
P
Y
R
D
N
L
L
D
K
D
I
A
T
D
G
E
L
A
A
E
R
A
I
N
L
I
D
K
Q
I
--
G
A
A
N
L
A
A
V
I
I
E
P
-
I
A
G
E
G
G
F
I
V
P
A
D
G
F
L
P
A
L
Q
R
W
C
R
D
N
D
V
V
F
I
A
D
E
V
Q
T
G
F
A
R
T
G
A
M
F
A
C
D
H
E
---
N
V
E
P
D
L
I
V
T
A
K
G
I
A
D
G
-
F
-
P
L
S
A
V
T
G
R
A
E
I
M
D
A
P
H
-------
T
S
G
L
G
G
T
F
G
G
N
P
V
A
C
A
A
A
L
A
T
I
E
T
I
E
R
D
G
M
V
E
R
A
R
Q
I
E
R
L
V
M
D
R
L
-
L
R
L
Q
A
-
A
--
D
-
D
R
L
G
D
V
R
G
R
G
A
M
I
A
M
E
L
V
K
S
G
T
A
-
E
P
---
D
-
A
A
L
T
Q
K
L
A
A
A
A
H
A
A
G
V
I
V
L
T
C
G
M
F
G
N
V
I
R
L
L
P
P
L
T
I
S
D
E
L
L
S
E
G
L
D
I
L
C
Q
I
L
A
D
-
114
HHSearch
96.41
78%
-107
- C2 -
3OKS
7
?
A:
[15-450]
---------
L
A
T
A
I
P
G
P
R
S
Q
A
L
I
D
R
K
G
T
A
V
A
R
G
V
G
T
T
M
P
V
-----
Y
A
------
V
R
A
G
-
G
G
I
V
E
D
V
D
G
N
R
L
I
D
L
G
S
G
I
A
V
T
T
V
G
N
S
A
P
K
V
V
E
A
V
R
S
Q
V
G
D
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
C
E
Q
L
N
R
-
L
T
P
V
R
G
D
K
R
S
A
L
F
N
S
G
S
E
A
V
E
N
A
V
K
I
A
R
S
H
T
--------
H
------
K
P
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
V
M
P
Y
K
D
G
F
G
P
F
A
P
E
I
Y
R
A
P
L
S
Y
P
F
R
D
A
E
F
G
K
E
L
A
T
D
G
E
L
A
A
K
R
A
I
T
V
I
D
K
Q
I
--
G
A
D
N
L
A
A
V
V
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
D
G
F
L
P
T
L
L
D
W
C
R
K
N
D
V
V
F
I
A
D
E
V
Q
T
G
F
A
R
T
G
A
M
F
A
C
E
H
---
E
G
I
D
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
G
R
A
E
I
M
D
S
P
H
-------
V
S
G
L
G
G
T
Y
G
G
N
P
I
A
C
A
A
A
L
A
T
I
E
T
I
E
S
E
G
L
V
A
R
A
Q
Q
I
E
K
I
M
K
D
R
L
-
G
R
L
Q
A
-
E
--
D
-
D
R
I
G
D
V
R
G
R
G
A
M
I
A
M
E
L
V
K
A
G
T
T
-
E
P
---
D
-
A
D
L
T
K
A
L
C
A
G
A
H
A
A
G
V
I
V
L
S
C
G
T
Y
G
N
V
V
R
F
L
P
P
L
S
I
G
D
D
L
L
N
E
G
L
D
V
L
E
E
V
L
R
G
-
2
PsiBlast_PDB
95.59
77%
-104
- C2 -
3OKS
7
?
A:
[10-448]
----
E
Q
S
R
H
L
A
T
A
I
P
G
P
R
S
Q
A
L
I
D
R
K
G
T
A
V
A
R
G
V
G
T
T
M
P
V
-----
Y
A
------
V
R
A
G
-
G
G
I
V
E
D
V
D
G
N
R
L
I
D
L
G
S
G
I
A
V
T
T
V
G
N
S
A
P
K
V
V
E
A
V
R
S
Q
V
G
D
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
C
E
Q
L
N
R
-
L
T
P
V
R
G
D
K
R
S
A
L
F
N
S
G
S
E
A
V
E
N
A
V
K
I
A
R
S
H
T
--------
H
------
K
P
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
V
M
P
Y
K
D
G
F
G
P
F
A
P
E
I
Y
R
A
P
L
S
Y
P
F
R
D
A
E
F
G
K
E
L
A
T
D
G
E
L
A
A
K
R
A
I
T
V
I
D
K
Q
I
--
G
A
D
N
L
A
A
V
V
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
D
G
F
L
P
T
L
L
D
W
C
R
K
N
D
V
V
F
I
A
D
E
V
Q
T
G
F
A
R
T
G
A
M
F
A
C
E
H
E
---
G
I
D
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
G
R
A
E
I
M
D
S
P
H
-------
V
S
G
L
G
G
T
Y
G
G
N
P
I
A
C
A
A
A
L
A
T
I
E
T
I
E
S
E
G
L
V
A
R
A
Q
Q
I
E
K
I
M
K
D
R
L
-
G
R
L
Q
A
-
E
--
D
-
D
R
I
G
D
V
R
G
R
G
A
M
I
A
M
E
L
V
K
A
G
T
T
-
E
P
---
D
-
A
D
L
T
K
A
L
C
A
G
A
H
A
A
G
V
I
V
L
S
C
G
T
Y
G
N
V
V
R
F
L
P
P
L
S
I
G
D
D
L
L
N
E
G
L
D
V
L
E
E
V
L
---
21
PsiBlast_CBE
92.71
68%
-104
- C2 -
3Q8N
2
?
D:
[15-452]
--
T
L
T
Q
E
R
R
L
V
T
A
I
P
G
P
I
S
Q
E
L
Q
A
R
K
Q
S
A
V
A
A
G
V
G
V
T
L
P
V
-----
Y
V
------
V
A
A
G
-
G
G
V
L
A
D
A
D
G
N
Q
L
I
D
F
G
S
G
I
A
V
T
T
V
G
N
S
A
P
A
V
V
D
A
V
T
Q
Q
V
A
A
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
K
V
A
E
H
L
N
R
-
L
T
P
G
D
H
E
K
R
T
A
L
F
N
S
G
A
E
A
V
E
N
A
V
K
I
A
R
A
Y
T
--------
R
------
R
Q
A
V
V
V
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
M
T
A
K
N
Q
P
Y
K
H
G
F
G
P
F
A
N
E
V
Y
R
V
P
T
S
Y
P
F
R
D
G
------
E
T
D
G
A
A
A
A
A
H
A
L
D
L
I
N
K
Q
V
--
G
A
D
N
V
A
A
V
V
I
E
P
-
V
H
G
E
G
G
F
V
V
P
A
P
G
F
L
G
A
L
Q
K
W
C
T
D
N
G
A
V
F
V
A
D
E
V
Q
T
G
F
A
R
T
G
A
L
F
A
C
E
H
E
---
N
V
V
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
G
R
A
E
I
M
D
G
P
Q
-------
S
G
G
L
G
G
T
Y
G
G
N
P
L
A
C
A
A
A
L
A
V
I
D
T
I
E
R
E
N
L
V
A
R
A
R
A
I
G
E
T
M
L
S
R
L
-
G
A
L
A
A
-
A
--
D
-
P
R
I
G
E
V
R
G
R
G
A
M
I
A
V
E
L
V
K
P
G
T
T
-
E
P
---
D
-
A
D
L
T
K
R
V
A
A
A
A
H
A
Q
G
L
V
V
L
T
C
G
T
Y
G
N
V
L
R
F
L
P
P
L
S
M
P
D
H
L
L
D
E
G
L
D
I
L
A
A
V
F
A
E
V
113
HHSearch
92.40
64%
-106
- C2 -
4ATQ
4
?
A:
[20-454]
-----------
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
E
E
----
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
---
E
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
-
E
--
L
S-
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
K
A
-
32
PsiBlast_CBE
92.34
62%
-104
- C2 -
4ATP
2
?
H:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
36
PsiBlast_CBE
92.27
62%
-105
- C2 -
4ATP
2
?
C:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
-
E
LS---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
31
PsiBlast_CBE
91.99
62%
-104
- C2 -
4ATP
2
?
J:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
-------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
29
PsiBlast_CBE
91.98
62%
-103
- C2 -
4ATQ
4
?
C:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
-
E
LS---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
3
PsiBlast_PDB
91.97
68%
-104
- C2 -
3Q8N
2
?
A:
[15-452]
--
T
L
T
Q
E
R
R
L
V
T
A
I
P
G
P
I
S
Q
E
L
Q
A
R
K
Q
S
A
V
A
A
G
V
G
V
T
L
P
V
-----
Y
V
------
V
A
A
G
-
G
G
V
L
A
D
A
D
G
N
Q
L
I
D
F
G
S
G
I
A
V
T
T
V
G
N
S
A
P
A
V
V
D
A
V
T
Q
Q
V
A
A
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
K
V
A
E
H
L
N
R
-
L
T
P
G
D
H
E
K
R
T
A
L
F
N
S
G
A
E
A
V
E
N
A
V
K
I
A
R
A
Y
T
--------
R
------
R
Q
A
V
V
V
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
M
T
A
K
N
Q
P
Y
K
H
G
F
G
P
F
A
N
E
V
Y
R
V
P
T
S
Y
P
F
R
D
G
------
E
T
D
G
A
A
A
A
A
H
A
L
D
L
I
N
K
Q
V
--
G
A
D
N
V
A
A
V
V
I
E
P
-
V
H
G
E
G
G
F
V
V
P
A
P
G
F
L
G
A
L
Q
K
W
C
T
D
N
G
A
V
F
V
A
D
E
V
Q
T
G
F
A
R
T
G
A
L
F
A
C
E
H
E
---
N
V
V
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
G
R
A
E
I
M
D
G
P
Q
-------
S
G
G
L
G
G
T
Y
G
G
N
P
L
A
C
A
A
A
L
A
V
I
D
T
I
E
R
E
N
L
V
A
R
A
R
A
I
G
E
T
M
L
S
R
L
-
G
A
L
A
A
-
A
--
D
-
P
R
I
G
E
V
R
G
R
G
A
M
I
A
V
E
L
V
K
P
G
T
T
-
E
P
---
D
-
A
D
L
T
K
R
V
A
A
A
A
H
A
Q
G
L
V
V
L
T
C
G
T
Y
G
N
V
L
R
F
L
P
P
L
S
M
P
D
H
L
L
D
E
G
L
D
I
L
A
A
V
F
A
E
V
22
PsiBlast_CBE
91.95
68%
-104
- C2 -
3Q8N
2
?
C:
[15-452]
--
T
L
T
Q
E
R
R
L
V
T
A
I
P
G
P
I
S
Q
E
L
Q
A
R
K
Q
S
A
V
A
A
G
V
G
V
T
L
P
V
-----
Y
V
------
V
A
A
G
-
G
G
V
L
A
D
A
D
G
N
Q
L
I
D
F
G
S
G
I
A
V
T
T
V
G
N
S
A
P
A
V
V
D
A
V
T
Q
Q
V
A
A
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
K
V
A
E
H
L
N
R
-
L
T
P
G
D
H
E
K
R
T
A
L
F
N
S
G
A
E
A
V
E
N
A
V
K
I
A
R
A
Y
T
--------
R
------
R
Q
A
V
V
V
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
M
T
A
K
N
Q
P
Y
K
H
G
F
G
P
F
A
N
E
V
Y
R
V
P
T
S
Y
P
F
R
D
G
------
E
T
D
G
A
A
A
A
A
H
A
L
D
L
I
N
K
Q
V
--
G
A
D
N
V
A
A
V
V
I
E
P
-
V
H
G
E
G
G
F
V
V
P
A
P
G
F
L
G
A
L
Q
K
W
C
T
D
N
G
A
V
F
V
A
D
E
V
Q
T
G
F
A
R
T
G
A
L
F
A
C
E
H
E
---
N
V
V
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
G
R
A
E
I
M
D
G
P
Q
-------
S
G
G
L
G
G
T
Y
G
G
N
P
L
A
C
A
A
A
L
A
V
I
D
T
I
E
R
E
N
L
V
A
R
A
R
A
I
G
E
T
M
L
S
R
L
-
G
A
L
A
A
-
A
--
D
-
P
R
I
G
E
V
R
G
R
G
A
M
I
A
V
E
L
V
K
P
G
T
T
-
E
P
---
D
-
A
D
L
T
K
R
V
A
A
A
A
H
A
Q
G
L
V
V
L
T
C
G
T
Y
G
N
V
L
R
F
L
P
P
L
S
M
P
D
H
L
L
D
E
G
L
D
I
L
A
A
V
F
A
E
V
23
PsiBlast_CBE
91.69
68%
-102
- C2 -
3Q8N
2
?
B:
[15-452]
--
T
L
T
Q
E
R
R
L
V
T
A
I
P
G
P
I
S
Q
E
L
Q
A
R
K
Q
S
A
V
A
A
G
V
G
V
T
L
P
V
-----
Y
V
------
V
A
A
G
-
G
G
V
L
A
D
A
D
G
N
Q
L
I
D
F
G
S
G
I
A
V
T
T
V
G
N
S
A
P
A
V
V
D
A
V
T
Q
Q
V
A
A
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
K
V
A
E
H
L
N
R
-
L
T
P
G
D
H
E
K
R
T
A
L
F
N
S
G
A
E
A
V
E
N
A
V
K
I
A
R
A
Y
T
--------
R
------
R
Q
A
V
V
V
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
M
T
A
K
N
Q
P
Y
K
H
G
F
G
P
F
A
N
E
V
Y
R
V
P
T
S
Y
P
F
R
D
G
------
E
T
D
G
A
A
A
A
A
H
A
L
D
L
I
N
K
Q
V
--
G
A
D
N
V
A
A
V
V
I
E
P
-
V
H
G
E
G
G
F
V
V
P
A
P
G
F
L
G
A
L
Q
K
W
C
T
D
N
G
A
V
F
V
A
D
E
V
Q
T
G
F
A
R
T
G
A
L
F
A
C
E
H
E
---
N
V
V
P
D
L
I
V
T
A
K
G
I
A
G
G
-
L
-
P
L
S
A
V
T
G
R
A
E
I
M
D
G
P
Q
-------
S
G
G
L
G
G
T
Y
G
G
N
P
L
A
C
A
A
A
L
A
V
I
D
T
I
E
R
E
N
L
V
A
R
A
R
A
I
G
E
T
M
L
S
R
L
-
G
A
L
A
A
-
A
--
D
-
P
R
I
G
E
V
R
G
R
G
A
M
I
A
V
E
L
V
K
P
G
T
T
-
E
P
---
D
-
A
D
L
T
K
R
V
A
A
A
A
H
A
Q
G
L
V
V
L
T
C
G
T
Y
G
N
V
L
R
F
L
P
P
L
S
M
P
D
H
L
L
D
E
G
L
D
I
L
A
A
V
F
A
E
V
25
PsiBlast_CBE
91.62
62%
-102
- C2 -
4ATQ
2
?
H:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
34
PsiBlast_CBE
91.54
62%
-104
- C2 -
4ATP
2
?
F:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
-------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
5
PsiBlast_PDB
91.51
62%
-103
- C2 -
4ATP
2
?
A:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
-
E
LS---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
27
PsiBlast_CBE
91.50
62%
-102
- C2 -
4ATQ
4
?
F:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
-
E
G-
G
-
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
35
PsiBlast_CBE
91.38
62%
-103
- C2 -
4ATP
2
?
D:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
-------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
33
PsiBlast_CBE
91.17
62%
-104
- C2 -
4ATP
2
?
G:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
6
PsiBlast_PDB
91.11
62%
-103
- C2 -
4ATQ
4
?
A:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
A
-
E
LS---
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
30
PsiBlast_CBE
91.10
62%
-104
- C2 -
4ATP
2
?
K:
[12-452]
---
I
E
Q
K
R
N
I
N
G
A
F
P
G
P
K
S
Q
A
L
A
E
R
R
S
A
V
V
A
A
G
V
A
S
G
V
P
V
-----
Y
V
------
E
D
A
D
-
G
G
I
I
R
D
V
D
G
N
S
F
I
D
L
G
S
G
I
A
V
T
S
V
G
A
S
D
P
A
V
V
A
A
V
Q
E
A
A
A
H
F
T
H
T
C
F
M
V
T
P
Y
E
G
Y
V
A
V
T
E
Q
L
N
R
-
L
T
P
G
D
H
A
K
R
T
V
L
F
N
S
G
A
E
A
V
E
N
A
V
K
V
A
R
L
A
T
--------
G
------
R
D
A
V
V
A
F
D
H
A
Y
H
G
R
T
N
L
T
M
A
L
T
A
K
A
M
P
Y
K
T
N
F
G
P
F
A
P
E
V
Y
R
M
P
M
S
Y
P
F
R
----
E
E
N
P
E
I
T
G
A
E
A
A
K
R
A
I
T
M
I
E
K
Q
I
--
G
G
D
Q
V
A
A
I
I
I
E
P
-
I
Q
G
E
G
G
F
I
V
P
A
E
G
F
L
P
A
L
S
E
W
A
K
E
K
G
I
V
F
I
A
D
E
V
Q
S
G
F
C
R
T
G
E
W
F
A
V
D
H
E
---
G
V
V
P
D
I
I
T
M
A
K
G
I
A
G
G
-
L
-
P
L
S
A
I
T
G
R
A
D
L
L
D
A
V
H
-------
P
G
G
L
G
G
T
Y
G
G
N
P
V
A
C
A
A
A
L
A
A
I
D
T
M
E
Q
H
D
L
N
G
R
A
R
H
I
E
E
L
A
L
G
K
L
-
R
E
L
A
-------
S
V
V
G
D
I
R
G
R
G
A
M
L
A
I
E
L
V
Q
P
G
S
K
-
E
P
---
N
-
A
E
L
T
K
A
V
A
A
A
C
L
K
E
G
V
I
I
L
T
C
G
T
Y
G
N
V
I
R
L
L
P
P
L
V
I
S
D
E
L
L
I
D
G
L
E
V
L
A
A
A
I
---
122
HHSearch
72.57
33%
-102
* C2 *
4JF1
9
ARGD_SALTY
A:
[38-417]
------------------------------------
P
A
D
F
-----
I
P
------
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
-
A
T
F
---
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSP--
F
------
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
----------------------
L
H
A
V
K
A
V
M
---
D
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
---
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
----------
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
-
131
HHSearch
69.69
30%
-104
- C2 -
4NOG
3
?
A:
[14-419]
-------------
L
K
L
K
T
E
E
D
F
F
A
C
D
R
Q
Y
V
C
Q
N
-
Y
A
P
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
-
M
F
G
---
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
-
D
C
Y
N
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
----------------------
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
-
R
R
E
L
Y
G
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
D
S
D
A
I
-----------
D
P
N
D
V
V
M
K
L
K
E
N
G
I
L
S
K
P
T
R
--
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
K
S
F
L
A
-
132
HHSearch
69.57
31%
-104
- C2 -
3DOD
2
BIOK_BACSU
A:
[25-442]
------------------------------------
E
N
P
L
-----
I
I
------
E
S
G
T
-
G
I
K
V
K
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
-
I
S
P
K
K
-
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
GKP--
E
------
K
Q
K
F
I
A
M
K
------------------------------
S
Y
K
A
P
I
P
Y
V
Y
R
S
E
S
G
D
------
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
---
E
N
V
Q
P
D
L
M
A
A
G
K
G
I
T
G
G
-
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
DDYENLK
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
-
Q
D
L
H
A
----
L
-
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
S
K
E
T
K
E
P
YPA
D
-
R
R
I
G
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
L
G
---
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
-
68
PsiBlast_CBE
67.81
32%
-90
- C2 -
4JEX
17
ARGD_SALTY
A:
[39-408]
----------------------------------------AD---
F
I
------
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
70
PsiBlast_CBE
67.73
31%
-90
- C2 -
2PB2
6
ARGD_SALTY
A:
[39-408]
-----------------------------------------------ADFIP-
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
73
PsiBlast_CBE
67.70
31%
-91
- C2 -
4JEY
13
ARGD_SALTY
B:
[33-408]
-------------------------------------
L
P
V
-----
Y
A
P
AD
F
I
P
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
67
PsiBlast_CBE
67.28
32%
-91
- C2 -
4JEX
17
ARGD_SALTY
B:
[33-408]
-------------------------------------
L
P
V
K
A
P
AD
F
I
------
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
52
PsiBlast_CBE
67.25
31%
-90
- C2 -
4JEW
13
ARGD_SALTY
B:
[31-408]
-----------------------------------
V
I
L
P
V
-----
Y
A
P
ADFIP
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
87
PsiBlast_CBE
67.11
31%
-92
- C2 -
5EQC
7
?
A:
[52-419]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------
65
PsiBlast_CBE
67.03
31%
-89
- C2 -
4JF1
9
ARGD_SALTY
B:
[33-408]
-------------------------------------
L
P
V
-----
Y
A
P
AD
F
I
P
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
71
PsiBlast_CBE
66.88
31%
-90
- C2 -
2PB0
5
ARGD_SALTY
B:
[33-408]
-------------------------------------
L
P
V
-----
Y
A
P
ADFIP
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
-------
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
72
PsiBlast_CBE
66.75
31%
-89
- C2 -
2PB0
5
ARGD_SALTY
A:
[27-408]
-------------------------------
T
F
D
E
V
I
L
P
V
-----
Y
A
PADFIP
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
94
PsiBlast_CBE
66.65
31%
-90
- C2 -
4NOG
6
?
B:
[37-404]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------
74
PsiBlast_CBE
66.62
31%
-88
- C2 -
4JEY
14
ARGD_SALTY
A:
[21-408]
-------------------------
T
A
I
T
R
A
T
F
D
E
V
I
L
P
V
-----
Y
A
PADFIP
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
66
PsiBlast_CBE
66.53
31%
-89
- C2 -
4JF1
9
ARGD_SALTY
A:
[27-408]
-------------------------------
T
F
D
E
V
I
L
P
V
-----
Y
A
PADFIP
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
90
PsiBlast_CBE
66.41
31%
-91
- C2 -
4ZWM
9
?
B:
[52-419]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------
91
PsiBlast_CBE
66.29
31%
-90
- C2 -
4ZWM
11
?
A:
[52-419]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------
53
PsiBlast_CBE
66.18
31%
-90
- C2 -
4JEZ
13
ARGD_SALTY
B:
[33-408]
-------------------------------------
L
P
V
-----
Y
A
P
AD
F
I
P
V
K
G
K
-
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
R
V
F
T
N
E
P
-----
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
----------------
D
L
H
A
V
K
A
--
V
M
D
-------
D
H
T
C
A
V
V
V
E
P
-
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
---
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
-
Q
A
I
D
E
-
Q
--
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
P
---
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
----------
95
PsiBlast_CBE
66.11
31%
-89
- C2 -
4NOG
3
?
A:
[37-404]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------
93
PsiBlast_CBE
65.63
31%
-89
- C2 -
4ZLV
5
?
A:
[52-419]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
E
VKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------
92
PsiBlast_CBE
65.33
31%
-89
- C2 -
4ZLV
6
?
B:
[52-419]
-------------------------------------
V
P
V
-----
V
I
------
S
K
G
K
-
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
R
A
F
----
G
N
D
V
T
G
P
A
C
R
F
-
M
A
E
M
F
G
Y
D
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
YEVKEIPP
D
------
S
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
-
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
G
P
F
T
P
G
F
----------------------
E
L
I
D
Y
D
D
V
G
A
L
E
E
A
L
--
K
D
P
N
V
A
A
F
F
V
E
P
-
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
---
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
L
K
-------
P
G
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
-
K
--
V
-
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
-
V
D
S
D
A
I
-
D
P
---
N
-
D
V
V
M
K
L
K
E
N
G
-------
I
L
S
K
P
T
R
G
R
V
M
R
F
I
P
P
L
V
I
T
D
E
----------------