@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3329: (2016-05-18 )
MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGYGRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTEAVETAWKVAKQYFKLTGKPGKQKVISRSIAYHGTTQGALAITGLPLFKAPFEPLTPGGFRVPNTNFYRAPLHTDLKEFGRWAADRIAEAIEFEGPDTVAAVFLEPVQNAGGCIPAPPGYFERVREICDRYDVLLVSDEVICAFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLGAMIASDRLFEPFNDGETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRNSPALRATLEKLYDLPIVGDIRGEGYFFGIELVKDQATKQTFTDDERARLLGQVSAALFEAGLYCRTDDRGDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL
Atome Classification :
(39 SA)
.........10........20........30........40....-....50........60-....--.-.-..70.-...-....80--........90-........100.......110.......120.......130.......140...-....150.....--..160.......170.....-..180.......190-----........200.......210.......220.......230.......240.......250.-......260.......270.......280.--.---...-..290--........300.......310.......320--........-.-330--........340--.-.-...--...350.......360.......370.......380..-.----....390.......400.......410....----...420.......430......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHFARHGAGIQH
P
V
I
V
RGD
G
V
T
I
FDDR
G
K
S
Y
L
D
A
LS
G
L
F
V
V
Q
VGY-
G
R
A
E
L
A
E
A
A
A
R
QAGTL-GYFP--L-W-GYATP-
P
A
I
-
E
L
A
E
R
L
--
A
R
YAPGDL
N
R
-
V
F
FTSGG
T
E
A
V
E
T
A
W
K
V
A
K
Q
Y
F
K
LTGKP
G
K
Q
K
V
I
S
R
S
I
A
YHGTTQG
A
L
A
ITGLP-LFKAPFEPLTPG--GFRVPNTN
F
Y
RA
P
L
H
T
D
L
K
E
-
F
G
R
W
A
A
D
R
I
A
E
A
IE------FEGP
D
T
V
A
A
V
F
L
E
P
V
Q
NAGGCIPAP
P
G
Y
F
E
R
V
R
E
I
C
D
RY
D
V
L
L
VS
D
E
V
I
C
A
FGRIG
S
M
F
A
C
E
-DLGYV
P
D
M
I
T
C
A
K
G
L
TSGY
S
P
L
G
A
M
I
A
SDR--L---FEP-FNDG---
E
T
M
F
A
H
G
Y
TFGG
H
P
V
S
A
AVGLA
N
L
D
I
F
ER----EG
L
S
D
H
V
K-R-N-S--
P
A
L
R
A
T
L
E
K
L
---Y-D-LP
I
--
V
G
DIRGE
G
Y
F
F
G
I
E
L
VKDQATKQTF
T
D
D
E
R
A
R
L
L
G
Q
V
S
-
A
----
A
L
F
EAG
L
Y
C
RTDDRGD
P
V
V
Q
VAPPLISGQPE----
F
D
T
I
E
T
I
L
R
S
V
L
T
DTGRKYLHL
108
HHSearch
91.62
39%
-95
- C1 -
3HMU
3
?
A:
[37-456]
----------
G
T
R
V
I
T
R
A
R
G
V
W
L
N
D
S
E
G
E
E
I
L
D
A
M
A
G
L
W
C
V
N
I
G
Y
-
G
R
D
E
L
A
E
V
A
A
R
Q
M
R
E
L
-
P
Y
Y
N
--
T
-
F
F
K
T
T
H
V
-
P
A
I
-
A
L
A
Q
K
L
--
A
E
L
A
P
G
D
L
N
H
-
V
F
F
A
G
G
G
S
E
A
N
D
T
N
I
R
M
V
R
T
Y
W
Q
N
K
G
Q
P
E
K
T
V
I
I
S
R
K
N
A
Y
H
G
S
T
V
A
S
S
A
L
G
G
M
A
-
G
M
H
A
Q
S
G
-
L
I
P
D
--
V
H
H
I
N
Q
P
N
W
W
A
E
G
G
D
M
D
P
E
E
-
F
G
L
A
R
A
R
E
L
E
E
A
I
L
------
E
L
G
E
N
R
V
A
A
F
I
A
E
P
V
Q
G
A
G
G
V
I
V
A
P
D
S
Y
W
P
E
I
Q
R
I
C
D
K
Y
D
I
L
L
I
A
D
E
V
I
C
G
F
G
R
T
G
N
W
F
G
T
Q
-
T
M
G
I
R
P
H
I
M
T
I
A
K
G
L
S
S
G
Y
A
P
I
G
G
S
I
V
C
D
E
--
V
---
A
H
V
-
I
G
K
-----
D
E
F
N
H
G
Y
T
Y
S
G
H
P
V
A
A
A
V
A
L
E
N
L
R
I
L
E
E
----
E
N
I
L
D
H
V
R
-
N
-
V
-
A
A
-
P
Y
L
K
E
K
W
E
A
L
---
T
-
D
-
H
P
L
--
V
G
E
A
K
I
V
G
M
M
A
S
I
A
L
T
P
N
K
A
S
R
A
K
F
A
S
E
-
P
G
T
I
G
Y
I
C
R
-
E
----
R
C
F
A
N
N
L
I
M
R
H
V
--
G
-
D
R
M
I
I
S
P
P
L
V
I
T
P
A
E
----
I
D
E
M
F
V
R
I
R
K
S
L
D
E
A
Q
A
E
I
---
21
PsiBlast_CBE
91.27
40%
-94
- C1 -
3HMU
3
?
B:
[40-451]
-------------
V
I
T
R
A
R
G
V
W
L
N
D
S
E
G
E
E
I
L
D
A
M
A
G
L
W
C
V
N
I
G
Y
-
G
R
D
E
L
A
E
V
A
A
R
Q
M
R
E
L
-
P
Y
Y
N
--
T
-
F
-
F
K
T
T
H
V
P
A
I
-
A
L
A
Q
K
L
--
A
E
L
A
P
G
D
L
N
H
-
V
F
F
A
G
G
G
S
E
A
N
D
T
N
I
R
M
V
R
T
Y
W
Q
N
K
G
Q
P
E
K
T
V
I
I
S
R
K
N
A
Y
H
G
S
T
V
A
S
S
A
L
G
G
M
A
-
G
M
H
A
Q
-
S
G
L
I
P
D
--
V
H
H
I
N
Q
P
N
W
W
A
E
G
G
D
M
D
P
E
E
-
F
G
L
A
R
A
R
E
L
E
E
A
I
L
------
E
L
G
E
N
R
V
A
A
F
I
A
E
P
V
Q
G
A
G
G
V
I
V
A
P
D
S
Y
W
P
E
I
Q
R
I
C
D
K
Y
D
I
L
L
I
A
D
E
V
I
C
G
F
G
R
T
G
N
W
F
G
T
Q
-
T
M
G
I
R
P
H
I
M
T
I
A
K
G
L
S
S
G
Y
A
P
I
G
G
S
I
V
C
D
E
--
V
---
A
H
V
-
I
--
G
---
K
D
E
F
N
H
G
Y
T
Y
S
G
H
P
V
A
A
A
V
A
L
E
N
L
R
I
L
E
E
----
E
N
I
L
D
H
V
R
-
N
V
A
-
A
--
P
Y
L
K
E
K
W
E
A
L
---
T
-
D
-
H
P
L
--
V
G
E
A
K
I
V
G
M
M
A
S
I
A
L
T
P
N
K
A
S
R
A
K
F
A
S
E
P
G
T
--
I
G
Y
I
C
R
E
----
R
C
F
A
N
N
L
I
M
R
--
H
V
G
D
R
M
I
-
I
S
P
P
L
V
I
T
P
A
E
----
I
D
E
M
F
V
R
I
R
K
S
L
D
E
--------
1
PsiBlast_PDB
91.19
40%
-93
- C1 -
3HMU
3
?
A:
[40-451]
-------------
V
I
T
R
A
R
G
V
W
L
N
D
S
E
G
E
E
I
L
D
A
M
A
G
L
W
C
V
N
I
G
Y
-
G
R
D
E
L
A
E
V
A
A
R
Q
M
R
E
L
-
P
Y
Y
N
--
T
-
F
-
F
K
T
T
H
V
P
A
I
-
A
L
A
Q
K
L
--
A
E
L
A
P
G
D
L
N
H
-
V
F
F
A
G
G
G
S
E
A
N
D
T
N
I
R
M
V
R
T
Y
W
Q
N
K
G
Q
P
E
K
T
V
I
I
S
R
K
N
A
Y
H
G
S
T
V
A
S
S
A
L
G
G
M
A
-
G
M
H
A
Q
-
S
G
L
I
P
D
--
V
H
H
I
N
Q
P
N
W
W
A
E
G
G
D
M
D
P
E
E
-
F
G
L
A
R
A
R
E
L
E
E
A
I
L
------
E
L
G
E
N
R
V
A
A
F
I
A
E
P
V
Q
G
A
G
G
V
I
V
A
P
D
S
Y
W
P
E
I
Q
R
I
C
D
K
Y
D
I
L
L
I
A
D
E
V
I
C
G
F
G
R
T
G
N
W
F
G
T
Q
-
T
M
G
I
R
P
H
I
M
T
I
A
K
G
L
S
S
G
Y
A
P
I
G
G
S
I
V
C
D
E
--
V
---
A
H
V
-
I
--
G
---
K
D
E
F
N
H
G
Y
T
Y
S
G
H
P
V
A
A
A
V
A
L
E
N
L
R
I
L
E
E
----
E
N
I
L
D
H
V
R
-
N
V
A
-
A
--
P
Y
L
K
E
K
W
E
A
L
---
T
-
D
-
H
P
L
--
V
G
E
A
K
I
V
G
M
M
A
S
I
A
L
T
P
N
K
A
S
R
A
K
F
A
S
E
P
G
T
--
I
G
Y
I
C
R
E
----
R
C
F
A
N
N
L
I
M
R
--
H
V
G
D
R
M
I
-
I
S
P
P
L
V
I
T
P
A
E
----
I
D
E
M
F
V
R
I
R
K
S
L
D
E
--------
24
PsiBlast_CBE
89.31
36%
-99
- C1 -
4BA4
1
?
B:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
25
PsiBlast_CBE
89.04
36%
-99
- C1 -
4AH3
2
?
D:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
110
HHSearch
88.55
35%
-100
- C1 -
4A6R
2
?
A:
[34-453]
------------
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
F
F
-
K
T
T
H
P
-
A
V
V
-
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
---
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
----
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
D
D
-
I
-
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
S
R
-
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
-
E
L
F
-
P
D
F
G
E
I
G
T
L
C
R
-
D
----
I
F
F
R
N
N
L
I
M
R
A
C
--
G
-
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
---
27
PsiBlast_CBE
87.95
36%
-99
- C1 -
4AH3
2
?
B:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
33
PsiBlast_CBE
87.90
36%
-99
- C1 -
4A6R
2
?
B:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
----
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
26
PsiBlast_CBE
87.76
36%
-97
- C1 -
4AH3
2
?
C:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
23
PsiBlast_CBE
87.76
36%
-96
- C1 -
4BA5
2
?
B:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
11
PsiBlast_PDB
87.57
36%
-100
- C1 -
4BA4
-
?
A:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
7
PsiBlast_PDB
87.55
36%
-99
- C1 -
4A6R
2
?
A:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
---
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
32
PsiBlast_CBE
86.88
36%
-98
- C1 -
4A6T
2
?
B:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
31
PsiBlast_CBE
86.63
36%
-98
- C1 -
4A6T
2
?
C:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
LCRD
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
19
PsiBlast_PDB
86.60
34%
-96
- C1 -
4E3Q
5
?
A:
[52-472]
-------------
V
V
T
H
G
E
G
P
Y
I
V
D
V
N
G
R
R
Y
L
D
A
N
S
G
L
W
N
M
V
A
G
F
-
D
H
K
G
L
I
D
A
A
K
A
Q
Y
E
R
F
P
G
Y
H
A
--
F
-
F
-
G
R
M
S
D
-
Q
T
V
-
M
L
S
E
K
L
--
V
E
V
S
P
F
D
S
G
R
-
V
F
Y
T
N
S
G
S
E
A
N
D
T
M
V
K
M
L
W
F
L
H
A
A
E
G
K
P
Q
K
R
K
I
L
T
R
W
N
A
Y
H
G
V
T
A
V
S
A
S
M
T
G
K
P
--
Y
N
S
V
F
G
L
P
L
P
G
--
F
V
H
L
T
C
P
H
Y
W
R
Y
G
E
E
G
E
T
E
E
Q
F
V
A
R
L
A
R
E
L
E
E
T
I
Q
------
R
E
G
A
D
T
I
A
G
F
F
A
E
P
V
M
G
A
G
G
V
I
P
P
A
K
G
Y
F
Q
A
I
L
P
I
L
R
K
Y
D
I
P
V
I
S
D
E
V
I
C
G
F
G
R
T
G
N
T
W
G
C
V
-
T
Y
D
F
T
P
D
A
I
I
S
S
K
N
L
T
A
G
F
F
P
M
G
A
V
I
L
G
P
E
--
L
S
K
R
L
E
T
-
A
I
E
A
---
I
E
E
F
P
H
G
F
T
A
S
G
H
P
V
G
C
A
I
A
L
K
A
I
D
V
V
M
N
----
E
G
L
A
E
N
V
R
-
R
-
L
-
A
--
P
R
F
E
E
R
L
K
H
I
---
A
-
E
-
R
P
N
--
I
G
E
Y
R
G
I
G
F
M
W
A
L
E
A
V
K
D
K
A
S
K
T
P
F
--
D
G
N
L
S
V
S
E
R
I
A
-
N
----
T
C
T
D
L
G
L
I
C
R
P
--
L
G
Q
S
V
V
-
L
C
P
P
F
I
L
T
E
A
Q
M
D
E
M
F
D
K
L
E
K
A
L
D
K
V
F
A
E
V
-------
18
PsiBlast_PDB
86.54
34%
-95
- C1 -
4E3R
1
?
A:
[52-472]
-------------
V
V
T
H
G
E
G
P
Y
I
V
D
V
N
G
R
R
Y
L
D
A
N
S
G
L
F
N
M
V
A
G
F
-
D
H
K
G
L
I
D
A
A
K
A
Q
Y
E
R
F
P
G
Y
H
A
--
A
-
F
-
G
K
M
S
D
-
Q
T
V
-
M
L
S
E
K
L
--
V
E
V
S
P
F
D
S
G
R
-
V
F
Y
T
N
S
G
S
E
A
N
D
T
M
V
K
M
L
W
F
L
H
A
A
E
G
K
P
Q
K
R
K
I
L
T
R
W
N
A
Y
H
G
A
T
A
V
S
A
S
M
T
G
F
P
--
Y
N
S
V
F
G
L
P
L
P
G
--
F
V
H
L
T
C
P
H
Y
W
R
Y
G
E
E
G
E
T
E
E
Q
F
V
A
R
L
A
R
E
L
E
E
T
I
Q
------
R
E
G
A
D
T
I
A
G
F
F
A
E
P
V
M
G
A
G
G
V
I
P
P
A
K
G
Y
F
Q
A
I
L
P
I
L
R
K
Y
D
I
P
V
I
S
D
E
V
V
C
G
F
G
R
T
G
N
T
W
G
C
V
-
T
Y
D
F
T
P
D
A
I
I
S
S
K
N
L
T
A
G
F
F
P
M
G
A
V
I
L
G
P
E
--
L
S
K
R
L
E
T
-
A
I
E
A
---
I
E
E
F
P
H
G
F
T
A
S
G
H
P
V
G
C
A
I
A
L
K
A
I
D
V
V
M
N
----
E
G
L
A
E
N
V
R
-
R
-
L
-
A
--
P
R
F
E
E
R
L
K
H
I
---
A
-
E
-
R
P
N
--
I
G
E
Y
R
G
I
G
F
M
W
A
L
E
A
V
K
D
K
A
S
K
T
P
F
--
D
G
N
L
S
V
S
E
R
I
A
-
N
----
T
C
T
D
L
G
L
I
C
F
P
--
L
G
Q
S
V
V
-
L
C
P
P
F
I
L
T
E
A
Q
M
D
E
M
F
D
K
L
E
K
A
L
D
K
V
F
A
E
V
-------
29
PsiBlast_CBE
86.53
36%
-97
- C1 -
4A72
2
?
C:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
-
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
12
PsiBlast_PDB
86.32
36%
-97
- C1 -
4BA5
1
?
A:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
10
PsiBlast_PDB
86.23
36%
-97
- C1 -
4AH3
2
?
A:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
28
PsiBlast_CBE
85.61
36%
-96
- C1 -
4A72
2
?
D:
[35-448]
-------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
-
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
-
P
F
Y
N
--
T
-
F
-
F
K
T
T
H
-
P
A
V
V
E
L
S
S
L
L
--
A
E
V
T
P
A
G
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
-
Y
M
H
E
Q
G
D
L
P
I
P
G
--
M
A
H
I
E
Q
P
W
W
Y
K
H
G
K
D
M
T
P
D
E
-
F
G
V
V
A
A
R
W
L
E
E
K
I
L
------
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
--
V
---
A
E
G
-
L
I
A
G
---
G
D
-
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
-
D
-
D
I
G
--
P
Y
M
Q
K
R
W
R
E
T
---
F
-
S
R
F
E
H
--
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
F
P
D
------
F
G
E
I
G
-
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
D
H
I
V
S
-
A
P
P
L
V
M
T
R
A
E
----
V
D
E
M
L
A
V
A
E
R
C
L
E
E
--------
103
HHSearch
84.31
35%
-99
- C1 -
3I5T
2
?
A:
[35-456]
---------
S
A
Q
P
V
L
T
H
A
E
G
I
Y
V
H
T
E
D
G
R
R
L
I
D
G
P
A
G
M
W
C
A
Q
V
G
Y
-
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
-
P
Y
A
S
--
P
-
W
-
Y
M
A
T
S
-
P
A
A
-
R
L
A
E
K
I
--
A
T
L
T
P
G
D
L
N
R
-
I
F
F
T
T
G
G
S
T
A
V
D
S
A
L
R
F
S
E
F
Y
N
N
V
L
G
R
P
Q
K
K
R
I
I
V
R
Y
D
G
Y
H
G
S
T
A
L
T
A
A
C
T
G
R
T
-
G
N
W
P
N
F
D
I
A
Q
D
R
--
I
S
F
L
S
S
P
N
P
R
H
A
G
-
N
R
S
Q
E
A
-
F
L
D
D
L
V
Q
E
F
E
D
R
I
E
------
S
L
G
P
D
T
I
A
A
F
L
A
E
P
I
L
A
S
G
G
V
I
I
P
P
A
G
Y
H
A
R
F
K
A
I
C
E
K
H
D
I
L
Y
I
S
D
E
V
V
T
G
F
G
R
C
G
E
W
F
A
S
E
K
V
F
G
V
V
P
D
I
I
T
F
A
K
G
V
T
S
G
Y
V
P
L
G
G
L
A
I
S
E
A
--
V
---
L
A
R
-
I
S
G
E
NAK
G
S
W
F
T
N
G
Y
T
Y
S
N
Q
P
V
A
C
A
A
A
L
A
N
I
E
L
M
E
R
----
E
G
I
V
D
Q
A
R
-
E
-
M
-
A
--
D
Y
F
A
A
A
L
A
S
L
---
R
-
D
-
L
P
G
--
V
A
E
T
R
S
V
G
L
V
G
C
V
Q
C
L
L
D
-----
G
T
A
E
--
D
K
A
F
T
L
K
I
D
-
E
----
R
C
F
E
L
G
L
I
V
R
P
L
--
G
-
D
L
C
V
I
S
P
P
L
I
I
S
R
A
Q
----
I
D
E
M
V
A
I
M
R
Q
A
I
T
E
V
S
A
-----
114
HHSearch
72.86
30%
-98
- C1 -
4JF1
9
ARGD_SALTY
A:
[37-419]
--------
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
-
W
H
T
S
--
N
---
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
--
I
D
A
T
F
--
A
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
------------------
D
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
-
T
-
K
-
R
--
Q
Q
F
V
Q
H
L
Q
A
I
---
D
E
Q
-
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
G
-----------
R
A
R
D
F
L
-
Y
----
A
G
A
E
A
G
V
M
V
L
N
A
--
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
------
60
PsiBlast_CBE
69.91
31%
-92
- C1 -
2EO5
3
?
A:
[27-415]
-------------
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
-
A
H
A
A
--
A
-
N
-
D
F
Y
N
I
-
P
Q
L
-
E
L
A
K
K
L
--
V
T
Y
S
P
G
N
F
Q
K
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-------
T
G
R
K
Y
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
G
P
F
M
P
G
--
V
I
H
V
P
Y
P
N
P
Y
R
N
P
W
H
I
N
G
Y
E
-
N
P
S
E
L
V
N
R
V
I
E
F
I
E
DYIFVN
L
V
P
P
E
E
V
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
-
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
A
T
I
F
R
K
D
--
L
D--
F
K
-----------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
D
------
L
L
P
H
V
N
-
E
-
I
-
G
--
K
I
F
A
E
E
L
Q
G
L
---
A
-
D
--------
D
V
R
G
I
G
L
A
W
G
L
E
Y
N
E
K
K
V
---------
R
D
R
I
I
G
E
S
---------
F
K
R
G
L
L
L
L
P
A
G
R
S
--
A
I
R
V
I
P
P
L
V
I
S
E
E
E
----
A
K
Q
G
L
D
I
L
K
K
V
I
----------
51
PsiBlast_CBE
68.03
33%
-90
- C1 -
2E54
5
ARGD_THEMA
A:
[15-382]
---------------
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
-
I
H
C
S
NL
F
-
W
----
N
R
-
P
Q
M
-
E
L
A
E
L
L
--
S
K
N
T
F
G
--
G
K
-
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
-
G
K
K
K
S
E
K
K
Y
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
-
K
Y
Q
K
P
F
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
V
E
D
L
R
R
K
M
S
E
D
------------------------------
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
-
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
V
-
P
I
G
A
V
I
V
N
E
R
AN
V
---
L
E
P
-
G
D
----------
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
----
E
G
F
L
E
E
V
E
-
E
-
K
-
G
--
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
-
D
---
V
--
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
E
E
V
S
N
R
E
V
A
T
K
C
F
E
N
K
L
L
--
V
V
-
P
----
A
-------------
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
----
I
D
L
A
V
E
T
L
K
K
V
L
----------
68
PsiBlast_CBE
66.73
31%
-91
* C1 *
1VEF
2
ARGD_THET8
A:
[30-394]
-------------
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
-
M
A
M
P
----
Q
-
T
L
P
T
P
-
M
R
G
-
E
F
Y
R
T
L
--
T
A
I
L
P
P
E
L
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
-
K
Y
R
E
P
F
L
P
L
V
E
P
--
V
E
F
I
P
---------
Y
N
D
V
E
A
-
L
K
R
-
A
V
D
-----------------
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
-
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
V
A
V
M
R
E
E
--
V
---
A
R
S
-
M
P
K
G
-------
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
-
E
-
L
-
G
--
P
W
F
---
M
E
K
L
---
R
-
A
-
I
P
S
PK
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-
K
E
K
A
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
--------------------
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
----------
67
PsiBlast_CBE
64.89
31%
-90
- C1 -
1VEF
2
ARGD_THET8
B:
[30-394]
-------------
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
-
M
A
M
P
----
Q
-
T
L
P
T
P
-
M
R
G
-
E
F
Y
R
T
L
--
T
A
I
L
P
P
E
L
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
-
K
Y
R
E
P
F
L
P
L
V
E
P
--
V
E
F
I
P
---------
Y
N
D
V
E
A
-
L
K
R
-
A
V
D
-----------------
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
-
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
-
P
L
G
V
A
V
M
R
E
E
--
V
---
A
R
S
-
M
P
K
G
-------
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
-
E
-
L
-
G
--
P
W
F
---
M
E
K
L
---
R
-
A
-
I
P
S
PK
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-
K
E
K
A
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
--------------------
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
----------
70
PsiBlast_CBE
54.69
32%
-91
- C1 -
4JEY
12
ARGD_SALTY
B:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
H
V
G
-------
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
-
F
-
V
--
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
79
PsiBlast_CBE
54.45
32%
-95
- C1 -
4JEW
11
ARGD_SALTY
A:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
--
H
T
K
-
R
-
Q
-
Q
F
V
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
75
PsiBlast_CBE
54.02
31%
-94
- C1 -
4JEZ
14
ARGD_SALTY
A:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
R
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
-
F
-
V
--
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
87
PsiBlast_CBE
53.96
31%
-93
- C1 -
2PB0
5
ARGD_SALTY
A:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
-
F
-
V
--
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
74
PsiBlast_CBE
53.62
31%
-93
- C1 -
4JEZ
12
ARGD_SALTY
B:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
R
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
-
F
-
V
--
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
86
PsiBlast_CBE
52.99
31%
-89
- C1 -
2PB0
5
ARGD_SALTY
B:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
H
V
G
-------
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
-
F
-
V
--
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
77
PsiBlast_CBE
52.92
32%
-95
- C1 -
4JEX
17
ARGD_SALTY
A:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
--
H
T
K
-
R
-
Q
-
Q
F
V
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
73
PsiBlast_CBE
52.76
32%
-93
- C1 -
4JF1
9
ARGD_SALTY
A:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
--
H
T
K
-
R
-
Q
-
Q
F
V
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
76
PsiBlast_CBE
52.71
32%
-94
- C1 -
4JEX
15
ARGD_SALTY
B:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
--
H
T
K
-
R
-
Q
-
Q
F
V
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
71
PsiBlast_CBE
52.67
32%
-92
- C1 -
4JEY
13
ARGD_SALTY
A:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
-----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
-
F
-
V
--
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
72
PsiBlast_CBE
52.54
32%
-89
- C1 -
4JF1
9
ARGD_SALTY
B:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
H
V
G
-------
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
--
H
T
K
-
R
-
Q
-
Q
F
V
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------
69
PsiBlast_CBE
52.25
33%
-89
- C1 -
4PPM
3
?
A:
[424-765]
-------------------
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
-
G
P
N
F
--
I
-
Q
-
Y
I
S
I
P
-
E
Q
T
A
K
L
A
E
V
L
--
C
R
L
A
P
G
N
M
G
R
-
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
---
T
G
K
P
G
I
A
Y
L
R
N
---
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
-
K
H
R
R
Y
F
T
P
L
L
D
A
--
M
V
E
V
P
----------------
F
G
D
L
A
A
L
R
--
E
A
L
N
------
R
E
---
D
V
G
A
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
-
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
P
I
G
A
T
L
C
R
A
D
--
L
---
W
Q
K
A
Y
G
T
A
---
D
R
F
L
V
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
----
Q
D
L
V
G
H
A
E
-
R
-
M
-
G
--
A
Y
F
K
Q
A
L
S
E
I
A
--
A
-
R
-
Y
P
F
--
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
--
D
Q
A
---------------------------------------------------------------------------------
78
PsiBlast_CBE
51.66
32%
-89
- C1 -
4JEW
12
ARGD_SALTY
B:
[44-361]
---------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
--
W
H
T
--
S
-
N
-
V
F
T
N
E
-
P
A
L
-
R
L
G
R
K
L
I
D
A
T
F
A
----
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
--
I
I
H
V
P
F
N
D
L
H
----------------------
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
-
P
V
S
A
M
L
T
T
Q
E
--
I
---
A
S
A
-
F
H
V
G
-------
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
--
H
T
K
-
R
-
Q
-
Q
F
V
Q
H
L
Q
A
I
D
E
Q
--------
F
D
I
--
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--------------------------------------------------------------------------------------