@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3518c: (2016-05-20 )
MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG
Atome Classification :
(30 SA)
.........10........20......-..30.----...---..-------..40........50......-.----.-60-----....-.--.------.--.-70.-.----.------.....80........90........100.......110.....--..---120--.-.......130.......140.......150.......160----...-......170.......180-.......190.......200....-.-..210........220.......230.......240.......250.......-260.......270......--.-280--........290.......300.......310.......320.......330.-..-....340.......350.......360.......370........380.......390......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTEAPDVDLADG
N
F
Y
A
S
R
E
A
R
A
A
Y
R
W
M
-RANQP----VFR---DR-------NGLA
A
A
S
T
Y
Q
A
V
IDAERQ
P
E
-
L
----
F
-SN-----AGGI-R--P------D--Q-PAL-
P
----
M
------
M
IDMD
D
P
A
H
L
L
R
R
K
L
VNAGFTRKRVKDKE
A
S
I
A
A
L
C
D
T
L
I
D
A
V
--CE---RG---E-
C
D
F
V
R
D
L
AAPL
P
M
A
V
I
G
D
M
LGVRPEQR
D
M
F
L
RWS
D
D
L
V
------
T
F
L
-
S
S
HVSQE
D
F
Q
I
T
M
D
A
F
A
A
Y-NDF
T
R
A
T
I
AARRAD
P
T
D
D
L
V
S
V
L
V
-S-SEV-DGERLS
D
D
E
L
V
M
E
T
L
L
I
L
IGGDET
T
R
HTLSG
G
T
E
Q
L
L
RNR
D
Q
W
D
L
L
QRD-PSL
L
P
G
A
I
E
E
M
L
R
WTA
P
V
K
--
N
-
M
-
C
--
R
V
LTADTEFH
G
T
A
LCAG
E
K
M
M
L
L
F
ESANFD
E
A
V
F
CEPE
K
F
DVQRNPNS
H
L
A
F
-GF-GTH
F
C
LGN
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
RLPD
L
R
L
VADDS-VLPL
R
P
A
N
F
V
S
G
L
ESM
P
V
V
FTPSPPLG
1
PsiBlast_PDB
99.52
100%
-102
- C6 -
2XKR
2
CP142_MYCTU
A:
[4-398]
---
A
P
D
V
D
L
A
D
G
N
F
Y
A
S
R
E
A
R
A
A
Y
R
W
M
-
R
A
N
Q
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
S
T
Y
Q
A
V
I
D
A
E
R
Q
P
E
-
L
----
F
-
S
N
-----
A
G
G
I
-
R
--
P
------
D
--
Q
-
P
A
L
-
P
----
M
------
M
I
D
M
D
D
P
A
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
K
D
K
E
A
S
I
A
A
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
L
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
R
P
E
Q
R
D
M
F
L
R
W
S
D
D
L
V
------
T
F
L
-
S
S
H
V
S
Q
E
D
F
Q
I
T
M
D
A
F
A
A
Y
-
N
D
F
T
R
A
T
I
A
A
R
R
A
D
P
T
D
D
L
V
S
V
L
V
-
S
-
S
E
V
-
D
G
E
R
L
S
D
D
E
L
V
M
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
N
R
D
Q
W
D
L
L
Q
R
D
-
P
S
L
L
P
G
A
I
E
E
M
L
R
W
T
A
P
V
K
--
N
-
M
-
C
--
R
V
L
T
A
D
T
E
F
H
G
T
A
L
C
A
G
E
K
M
M
L
L
F
E
S
A
N
F
D
E
A
V
F
C
E
P
E
K
F
D
V
Q
R
N
P
N
S
H
L
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
V
A
D
D
S
-
V
L
P
L
R
P
A
N
F
V
S
G
L
E
S
M
P
V
V
F
T
P
S
P
P
L
G
121
HHSearch
94.94
97%
-102
- C6 -
2XKR
2
CP142_MYCTU
A:
[19-398]
-------------------
E
A
R
A
A
Y
R
W
M
R
A
N
Q
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
S
T
Y
Q
A
V
I
D
A
E
R
Q
P
E
-
L
----
F
-
S
N
-----
A
G
G
I
-
R
--
P
------
D
--
Q
-
P
A
L
-
P
----
M
------
M
I
D
M
D
D
P
A
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
K
D
K
E
A
S
I
A
A
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
L
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
R
P
E
Q
R
D
M
F
L
R
W
S
D
D
L
V
------
T
F
L
-
S
S
H
V
S
Q
E
D
F
Q
I
T
M
D
A
F
A
A
Y
-
N
D
F
T
R
A
T
I
A
A
R
R
A
D
P
T
D
D
L
V
S
V
L
V
-
S
-
S
E
V
-
D
G
E
R
L
S
D
D
E
L
V
M
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
N
R
D
Q
W
D
L
L
Q
R
D
-
P
S
L
L
P
G
A
I
E
E
M
L
R
W
T
A
P
V
K
--
N
-
M
-
C
--
R
V
L
T
A
D
T
E
F
H
G
T
A
L
C
A
G
E
K
M
M
L
L
F
E
S
A
N
F
D
E
A
V
F
C
E
P
E
K
F
D
V
Q
R
N
P
N
S
H
L
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
V
A
D
D
S
V
L
P
L
R
P
A
-
N
F
V
S
G
L
E
S
M
P
V
V
F
T
P
S
P
P
L
G
27
PsiBlast_CBE
93.74
78%
-98
- C6 -
2YOO
2
?
D:
[6-399]
--
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
22
PsiBlast_CBE
93.73
78%
-99
- C6 -
3ZBY
10
?
F:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
5
PsiBlast_PDB
93.54
78%
-100
- C6 -
4UAX
1
?
A:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
2
PsiBlast_PDB
93.45
78%
-101
- C6 -
2YOO
2
?
A:
[5-399]
-
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
3
PsiBlast_PDB
93.44
78%
-101
- C6 -
3ZBY
5
?
A:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
26
PsiBlast_CBE
93.35
78%
-99
- C6 -
3ZBY
6
?
B:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
29
PsiBlast_CBE
93.23
78%
-99
- C6 -
2YOO
2
?
B:
[6-399]
--
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
21
PsiBlast_CBE
93.19
78%
-97
- C6 -
4TRI
3
?
B:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
28
PsiBlast_CBE
93.14
78%
-97
- C6 -
2YOO
2
?
C:
[6-399]
--
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
25
PsiBlast_CBE
93.01
78%
-100
- C6 -
3ZBY
6
?
C:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
24
PsiBlast_CBE
92.33
78%
-100
- C6 -
3ZBY
3
?
D:
[4-399]
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
4
PsiBlast_PDB
91.84
78%
-99
- C6 -
4TRI
3
?
A:
[5-399]
-
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
D
G
G
A
R
E
A
Y
R
W
M
-
R
A
N
E
P
----
V
F
R
---
D
R
-------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
-
L
----
F
-
S
S
-----
T
G
G
I
-
R
--
P
------
D
--
Q
-
P
G
M
-
P
----
Y
------
M
I
D
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
L
I
D
A
V
--
C
E
---
R
G
---
E
-
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
------
C
G
L
-
S
S
H
V
D
E
A
A
I
Q
K
L
M
D
T
F
A
A
Y
-
T
E
F
T
K
D
V
I
T
K
R
R
A
E
P
T
D
D
L
F
S
V
L
V
-
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
-
V
D
L
L
P
G
A
I
E
E
M
L
R
W
T
S
P
V
K
--
N
-
M
-
C
--
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
N
P
N
S
H
V
A
F
-
G
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
P
S
A
P
V
-
43
PsiBlast_CBE
79.40
35%
-95
- C6 -
3A4Z
4
CPVDH_PSEAH
C:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
LAL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
WRHRL
P
E
D
Q
-
R
--
A
------
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
12
PsiBlast_PDB
79.34
35%
-89
- C6 -
3A4G
2
CPVDH_PSEAH
A:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
L
AL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
-----
W
R
H
T
-
L
--
P
EDQRA-
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
19
PsiBlast_PDB
78.79
35%
-92
- C6 -
3VRM
2
CPVDH_PSEAH
A:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
L
AL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
-----
W
R
H
T
-
L
--
P
EDQRA-
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
35
PsiBlast_CBE
78.46
35%
-97
- C6 -
3A51
5
CPVDH_PSEAH
C:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
LAL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
WRHRL
P
E
D
Q
-
R
--
A
------
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
39
PsiBlast_CBE
78.44
35%
-94
- C6 -
3A50
5
CPVDH_PSEAH
C:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
LAL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
WRHRL
P
E
D
Q
-
R
--
A
------
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
38
PsiBlast_CBE
78.31
35%
-92
- C6 -
3A50
6
CPVDH_PSEAH
D:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
LAL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
WRHRL
P
E
D
Q
-
R
--
A
------
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
13
PsiBlast_PDB
77.71
35%
-85
- C6 -
3A4H
2
CPVDH_PSEAH
A:
[12-400]
-------
D
L
F
S
G
T
F
W
--
Q
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
L
AL
P
D
-------
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
-
L
----
S
-
K
D
-----
W
R
H
T
-
L
--
P
EDQRA-
D
--
M
-
P
A
T
-
P
TP--
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
-----------
D
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
----
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
-
A
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
-
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
-----
6
PsiBlast_PDB
76.50
35%
-77
- C6 -
2WM4
3
CP124_MYCTU
A:
[40-435]
---
A
L
D
D
D
V
R
D
G
A
F
A
T
L
R
R
E
A
P
I
S
F
W
P
-
T
I
E
L
P
----
G
F
V
---
A
G
-------
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
-
I
----
F
-
S
S
-----
Y
P
N
I
-
T
--
I
------
N
DQ
T
-
P
E
L
-
A
E
YFG
S
------
M
I
V
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
--
I
A
---
N
N
P
DR
Q
-
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
V
I
L
------
G
F
G
-
D
P
D
L
A
T
-
D
F
D
E
F
M
Q
V
S
A
D
I
-
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
-
E
-
A
E
V
-
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
T
A
V
E
E
I
V
R
W
A
S
P
V
V
--
Y
-
M
-
R
--
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
N
P
N
P
H
L
G
F
G
G
G
-
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
A
T
E
E
P
A
-
R
L
---
L
S
Q
F
I
H
G
I
K
T
L
P
V
T
W
S
------
140
HHSearch
76.49
35%
-83
- C6 -
3A4G
2
CPVDH_PSEAH
A:
[21-403]
------------------
N
P
H
P
A
Y
A
A
L
-
R
A
E
D
P
----
V
R
K
---
L
A
LPD----
G
P
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
----
K
-
D
W
-----
R
H
T
L
P
E
DQ
R
------
A
DM
P
A
T
P
T
-
P
----
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
--
P
T
---
D
G
---
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
------
D
D
-----
S
---
P
A
D
D
K
N
A
A
M
G
K
L
-
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
-
A
-
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
A
P
-
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
-
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
-
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
S
A
--
135
HHSearch
75.92
36%
-82
- C6 -
2WM5
1
CP124_MYCTU
A:
[45-434]
------------------
V
R
D
G
A
F
A
T
L
-
R
R
E
A
P
----
I
S
F
---
W
P
T
IELVA
G
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
-
I
----
F
-
S
S
-----
Y
P
N
I
-
T
--
I
NDQT
P
E
L
--
A
-
E
Y
F
-
G
----
S
------
M
I
V
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
--
I
A
N
N
P
D
R
---
Q
-
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
V
I
L
------
G
F
G
-
D
P
D
L
-
A
T
D
F
D
E
F
M
Q
V
S
A
D
I
-
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
-
E
-
A
E
V
-
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
T
A
V
E
E
I
V
R
W
A
S
P
V
V
--
Y
-
M
-
R
--
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
N
P
N
P
H
L
G
F
-
G
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
A
T
E
E
P
A
--
R
-
L
L
S
-
Q
F
I
H
G
I
K
T
L
P
V
T
W
-------
7
PsiBlast_PDB
75.47
35%
-75
- C6 -
2WM5
1
CP124_MYCTU
A:
[40-435]
---
A
L
D
D
D
V
R
D
G
A
F
A
T
L
R
R
E
A
P
I
S
F
W
P
-
T
I
E
L
-------
V
---
A
G
-------
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
-
I
----
F
-
S
S
-----
Y
P
N
I
-
T
--
I
------
N
DQ
T
-
P
E
L
-
A
E
Y
F
G
S
------
M
I
V
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
--
I
A
---
N
N
P
DR
Q
-
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
V
I
L
------
G
F
G
-
D
P
D
L
A
T
-
D
F
D
E
F
M
Q
V
S
A
D
I
-
G
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
H
D
D
L
T
S
S
L
V
-
E
-
A
E
V
-
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
T
A
V
E
E
I
V
R
W
A
S
P
V
V
--
Y
-
M
-
R
--
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
N
P
N
P
H
L
G
F
G
G
G
-
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
A
T
E
E
P
A
-
R
L
---
L
S
Q
F
I
H
G
I
K
T
L
P
V
T
W
S
------
20
PsiBlast_PDB
73.69
34%
-92
- C6 -
4GGV
1
?
A:
[35-392]
-----------------------
H
L
W
L
-
R
G
Q
R
P
ESP
V
V
F
D
---
E
T
-------
Q
G
V
W
N
V
Y
G
Y
P
E
A
M
D
I
L
N
D
H
D
-
T
----
F
T
S
D
-----
L
A
H
L
-
L
--
P
------
V
--
S
-
V
D
A
-
P
----
L
LEGD--
M
S
Q
M
D
P
P
R
H
R
K
Y
R
Q
L
V
S
R
A
F
T
P
R
L
V
A
D
M
E
T
R
V
A
D
I
T
R
E
L
L
D
A
V
--
D
G
---
K
P
---
E
-
I
E
I
A
A
D
L
A
Y
P
L
P
V
I
V
I
A
E
L
L
G
V
P
A
G
D
R
D
L
F
K
K
W
A
D
D
I
I
E
G
F
SGF
S
F
L
D
T
S
G
Q
G
E
Q
D
V
R
D
A
T
E
R
L
R
P
L
-
L
D
Y
M
A
G
H
V
T
E
R
R
R
T
P
R
E
D
L
L
T
H
L
V
-
Q
-
A
E
V
-
D
G
E
R
L
T
D
N
E
I
V
N
V
A
N
I
L
L
V
T
G
H
I
T
T
T
M
T
L
G
N
T
V
L
C
L
D
A
D
P
E
V
A
A
K
V
R
A
D
-
R
S
L
V
P
G
A
I
E
E
A
L
R
V
L
S
P
S
A
--
A
-
L
-
A
--
R
G
T
S
R
E
V
E
V
A
G
T
V
I
P
K
D
Q
I
V
M
L
W
L
G
A
G
N
R
D
P
R
Q
F
T
D
P
E
V
Y
D
P
T
R
D
P
N
P
H
F
G
F
-
G
R
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
G
R
V
A
L
N
A
L
F
D
R
F
P
V
L
R
----------------------------------
108
PsiBlast_CBE
69.95
33%
-93
- C6 -
3CV9
2
CPXE_STRGO
A:
[96-406]
----------------------------------------------------------------------------------------------------------------------------
I
G
L
D
P
P
E
H
G
T
R
R
R
M
T
I
S
E
F
T
V
K
R
I
K
G
M
R
P
E
V
E
E
V
V
H
G
F
L
D
E
M
--
L
A
---
A
G
P--
T
-
A
D
L
V
S
Q
F
A
L
P
V
P
S
M
V
I
C
R
L
L
G
V
P
Y
A
D
H
E
F
F
Q
D
A
S
K
R
L
V
--------------
Q
S
T
D
A
Q
S
A
L
T
A
R
N
D
L
-
A
G
Y
L
D
G
L
I
T
Q
F
Q
T
E
P
G
A
G
L
V
G
A
L
V
-
A
-
D
Q
L
-
A
N
G
E
I
D
R
E
E
L
I
S
T
A
M
L
L
L
I
A
G
H
E
T
T
A
S
M
T
S
L
S
V
I
T
L
L
D
H
P
E
Q
Y
A
A
L
R
A
D
-
R
S
L
V
P
G
A
V
E
E
L
L
R
Y
L
A
-
I
A
--
D
-
I
-
A
G
G
R
V
A
T
A
D
I
E
V
E
G
Q
L
I
R
A
G
E
G
V
I
V
V
N
S
I
A
N
R
D
G
T
V
Y
E
D
P
D
A
L
D
I
H
R
S
A
R
H
H
L
A
F
-
G
F
-
G
V
H
Q
C
L
G
Q
N
L
A
R
L
E
L
E
V
I
L
N
A
L
M
D
R
V
P
T
L
R
L
A
V
P
V
E
-
Q
L
V
L
R
P
G
T
T
I
Q
G
V
N
E
L
P
V
T
W
-------
82
PsiBlast_CBE
69.61
34%
-88
- C6 -
3ZPI
11
PIKC_STRVZ
A:
[112-423]
---------------------------------------------------------------------------------------------------------------------------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
G
---
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
--------------
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
-
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
-
A
-
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
-
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
-
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---------
59
PsiBlast_CBE
69.19
34%
-89
- C6 -
2BVJ
2
PIKC_STRVZ
B:
[112-423]
---------------------------------------------------------------------------------------------------------------------------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
G
---
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
--------------
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
-
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
-
A
-
T
Y
-
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
-
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
-
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
---------
45
PsiBlast_CBE
66.38
33%
-75
- C6 -
4XE3
8
?
B:
[31-401]
-----------------------
Y
A
E
L
-
R
R
D
E
P
----
V
S
R
---
V
R
-------
L
P
Y
G
E
G
T
A
W
L
V
T
R
M
S
D
A
R
I
V
-
L
GDSR
F
-
S
T
-----
A
A
A
T
-
D
--
P
------
A
--
T
-
P
R
M
F
P
----
T
PPEPDG
V
L
A
Q
D
P
P
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
M
--
V
A
---
H
G
---
S
P
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
E
L
L
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
------
S
---
S
T
R
L
T
A
A
E
I
Q
R
V
Q
Q
D
F
M
V
Y
-
M
D
---
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
-
L
-
A
T
D
-
N
D
D
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
E
R
K
R
Y
E
S
L
V
A
D
-
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
P
L
V
S
AG
S
-
F
-
V
--
R
V
A
T
E
D
V
E
L
S
T
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
D
H
A
D
E
L
D
F
H
R
E
R
N
P
H
I
A
F
-
G
H
-
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
P
T
L
D
L
A
E
P
V
A
-
G
L
K
W
K
Q
G
M
L
I
R
G
L
E
-------------