@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0447: (2016-01-05 )
MATKASFNWEDPLLLDQQLTEEERMVRDSAQQFAQDKLAPRVLEAFRHEQTDPKIFREMGETGLLGATIPEAYGGSGLNYVCYGLIAREVERVDSGYRSMMSVQSSLVMVPIHEFGNEATRQKYLPKLASGEYIGCFGLTEPNHGSDPGSMVTRAKKVDGGYRLSGSKMWITNSPIADVFVVWAKDDEGQIRGFVLEKGWEGLSAPAIHGKVGLRASITGEIVMDNVFVPEENAFPEVRGLRGPFTCLNSARYGISWGALGAAEFCWHTARQYVLDRQQFGRPLAANQLIQKKLADMQTEITLALQGCLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGIARHLVNLEVVNTYEGTHDVHALILGRAQTGIQAFF
Atome Classification :
(32 SA)
.........10........20........30........40.......-.50-..-.......60........70.......---.80........90........100.......110.......120.......130.......140.......150...--..--.-.160.......170.......180....--..---.---190---.........200.......210.......220.......230...-...-.240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATKASFNWEDP
L
L
L
D
Q
QL
T
E
E
E
R
M
V
R
D
S
A
Q
Q
F
A
Q
D
K
L
A
P
R
V
L
E
A
F
RH-EQ--T
D
-
P
K
I
F
R
E
MGETGLLGATI
P
E
AYGGS
G
L
---
N
Y
V
C
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
H
E
FG
N
E
A
T
R
Q
K
Y
L
P
K
LASG
E
Y
I
G
C
FGLTEPNHGSD
P
G
S
M
V
T
R
A
--KK--V-DG
G
Y
R
LSG
S
K
M
W
I
TNSPI
A
D
V
F
V
V
W
AKD--DE---G---Q-----
I
R
G
F
V
L
E
KGWEGLSAPAIHGKVG
L
R
A
S
I
T
G
E
I
V
M
D
N
V
FVPEENAF-PEV-RGLRG
P
F
T
C
L
NSARYGISWGA
L
G
A
A
E
F
C
W
H
T
A
R
Q
Y
V
L
D
R
Q
QFGR
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
A
L
Q
G
C
L
R
LGRMKDEG
T
A
A
V
E
I
T
S
I
M
KRNSCGK
A
L
D
I
A
R
L
A
R
D
M
LGGNGIS
D
E
F
G
I
A
R
H
L
V
N
L
E
V
V
NTYEGT
H
D
V
H
A
L
I
LGRAQTGIQAFF
31
PsiBlast_CBE
98.26
85%
-93
- C1 -
3GNC
3
?
B:
[8-397]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
---
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
-------
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
3
PsiBlast_PDB
98.11
85%
-92
- C1 -
3II9
3
?
A:
[5-396]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
------
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
99
HHSearch
98.10
86%
-92
- C1 -
3II9
3
?
A:
[4-396]
---
A
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
------
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
DG
R
D
---
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
5
PsiBlast_PDB
98.07
85%
-91
- C1 -
3GNC
2
?
A:
[8-397]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
RD-
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
--
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
4
PsiBlast_PDB
97.99
85%
-91
- C1 -
3GQT
1
?
A:
[8-398]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
-----
P
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
GRD
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
---
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
23
PsiBlast_CBE
97.80
85%
-88
- C1 -
3II9
9
?
C:
[5-396]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
----
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
1
PsiBlast_PDB
97.54
85%
-92
- C1 -
3D6B
-
?
A:
[4-393]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
---
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
-----
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
28
PsiBlast_CBE
97.38
85%
-92
- C1 -
3GQT
2
?
B:
[8-398]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
-----D--
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
-------
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
30
PsiBlast_CBE
97.30
85%
-89
- C1 -
3GNC
2
?
C:
[8-398]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
-----
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
---
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
22
PsiBlast_CBE
97.30
85%
-91
- C1 -
3II9
5
?
D:
[5-396]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
----
P
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
---
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
24
PsiBlast_CBE
97.04
85%
-92
- C1 -
3II9
3
?
B:
[5-396]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
-----
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
---
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
-----
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
29
PsiBlast_CBE
96.87
85%
-88
- C1 -
3GNC
3
?
D:
[8-397]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
-------
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
-----D--
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
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I
T
L
G
L
Q
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V
L
R
L
G
R
M
K
D
E
G
T
A
A
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E
I
T
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I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
27
PsiBlast_CBE
96.87
85%
-90
- C1 -
3GQT
1
?
C:
[8-398]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
S
D
P
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
------
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
-
2
PsiBlast_PDB
96.65
85%
-88
- C1 -
3EOM
-
?
A:
[4-395]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
----
D
P
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
GRD
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
-
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
21
PsiBlast_CBE
96.52
85%
-91
- C1 -
3D6B
1
?
C:
[4-393]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
N
H
G
---
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
---
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
-------
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
25
PsiBlast_CBE
96.01
85%
-91
- C1 -
3EON
1
?
C:
[5-394]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
------
G
S
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
E
---
D
G
R
D
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
--
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
26
PsiBlast_CBE
95.95
85%
-92
- C1 -
3GQT
1
?
D:
[8-397]
----
A
T
F
H
W
D
D
P
L
L
L
D
Q
Q
L
A
D
D
E
R
M
V
R
D
A
A
H
A
Y
A
Q
G
K
L
A
P
R
V
T
E
A
F
R
H
-
E
T
--
T
D
-
A
A
I
F
R
E
M
G
E
I
G
L
L
G
P
T
I
P
E
Q
Y
G
G
P
G
L
---
D
Y
V
S
Y
G
L
I
A
R
E
V
E
R
V
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
V
P
I
F
E
F
G
S
D
A
Q
K
E
K
Y
L
P
K
L
A
T
G
E
W
I
G
C
F
G
L
T
E
P
--------
M
V
T
R
A
--
R
K
--
V
-
P
G
G
Y
S
L
S
G
S
K
M
W
I
T
N
S
P
I
A
D
V
F
V
V
W
A
K
L
--
D
-----D--
E
-----
I
R
G
F
I
L
E
K
G
C
K
G
L
S
A
P
A
I
H
G
K
V
G
L
R
A
S
I
T
G
E
I
V
L
D
E
A
F
V
P
E
E
N
I
L
-
P
H
V
-
K
G
L
R
G
P
F
T
C
L
N
S
A
R
Y
G
I
A
W
G
A
L
G
A
A
E
S
C
W
H
I
A
R
Q
Y
V
L
D
R
K
Q
F
G
R
P
L
A
A
N
Q
L
I
Q
K
K
L
A
D
M
Q
T
E
I
T
L
G
L
Q
G
V
L
R
L
G
R
M
K
D
E
G
T
A
A
V
E
I
T
S
I
M
K
R
N
S
C
G
K
A
L
D
I
A
R
L
A
R
D
M
L
G
G
N
G
I
S
D
E
F
G
V
A
R
H
L
V
N
L
E
V
V
N
T
Y
E
--
H
D
I
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
--
32
PsiBlast_CBE
91.24
69%
-90
- C1 -
4W9U
3
?
D:
[5-395]
----
A
A
F
A
W
E
D
P
F
L
L
E
E
Q
L
T
E
D
E
R
M
I
R
D
S
A
K
A
F
A
S
D
V
L
L
P
R
V
E
----------
T
D
-
P
E
L
F
H
L
M
G
Q
A
G
L
L
G
V
T
L
P
E
D
Y
G
A
A
N
A
---
S
Y
V
A
Y
G
L
V
A
R
E
V
E
R
I
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
D
E
Q
R
K
K
Y
L
P
G
L
V
S
G
E
L
I
G
C
F
G
L
T
E
P
D
A
G
S
--
A
G
M
K
T
R
A
--
E
K
--
I
-
D
G
G
Y
R
L
S
G
S
K
M
W
I
S
N
S
P
I
A
D
V
F
V
V
W
A
K
S
AA
H
D
---
N
---
A
-----
I
R
G
F
I
L
E
K
G
M
K
G
L
S
A
P
K
I
G
G
K
-
S
L
R
A
S
I
T
G
E
I
V
M
D
G
V
E
V
S
E
D
A
I
L
-
P
N
V
-
S
G
L
K
G
P
F
G
C
L
N
R
A
R
Y
G
I
S
W
G
V
L
G
A
A
E
D
C
W
F
R
A
R
Q
Y
G
L
D
R
K
Q
F
N
K
P
L
A
G
T
Q
L
Y
Q
K
K
L
A
D
M
Q
T
E
I
A
L
G
I
Q
A
S
L
R
V
G
R
L
F
D
E
G
K
M
A
P
E
M
I
S
I
V
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
H
G
------
E
Y
H
V
M
R
H
A
Q
N
L
E
T
V
N
T
Y
E
G
T
H
D
V
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
34
PsiBlast_CBE
90.86
69%
-89
- C1 -
4W9U
1
?
B:
[4-395]
---
R
A
A
F
A
W
E
D
P
F
L
L
E
E
Q
L
T
E
D
E
R
M
I
R
D
S
A
K
A
F
A
S
D
V
L
L
P
R
V
E
K
---
E
-
E
T
--
T
D
-
P
E
L
F
H
L
M
G
Q
A
G
L
L
G
V
T
L
P
E
D
Y
G
A
A
N
A
---
S
Y
V
A
Y
G
L
V
A
R
E
V
E
R
I
D
S
G
Y
R
S
M
M
S
V
Q
S
S
L
V
M
Y
P
I
Y
A
Y
G
S
D
E
Q
R
K
K
Y
L
P
G
L
V
S
G
E
L
I
G
C
F
G
L
T
E
P
----
D
P
A
G
M
K
T
R
A
--
E
K
--
I
-
D
G
G
Y
R
L
S
G
S
K
M
W
I
S
N
S
P
I
A
D
V
F
V
V
W
A
K
S
AA
H
D
---
N
---
A
-----
I
R
G
F
I
L
E
K
G
M
K
G
L
S
A
P
K
I
G
G
---
L
R
A
S
I
T
G
E
I
V
M
D
G
V
E
V
S
E
D
A
I
L
-
P
N
V
-
S
G
L
K
G
P
F
G
C
L
N
R
A
R
Y
G
I
S
W
G
V
L
G
A
A
E
D
C
W
F
R
A
R
Q
Y
G
L
D
R
K
Q
F
N
K
P
L
A
G
T
Q
L
Y
Q
K
K
L
A
D
M
Q
T
E
I
A
L
G
I
Q
A
S
L
R
V
G
R
L
F
D
E
G
K
M
A
P
E
M
I
S
I
V
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
H
G
------
E
Y
H
V
M
R
H
A
Q
N
L
E
T
V
N
T
Y
E
G
T
H
D
V
H
A
L
I
L
G
R
A
Q
T
G
I
Q
A
F
F
8
PsiBlast_PDB
90.68
65%
-87
- C1 -
1SIR
2
GCDH_HUMAN
A:
[3-390]
-----
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
--
F
H
-
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
---
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
--
S
-
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
--
E
D
---
G
---
C
-----
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
7
PsiBlast_PDB
89.98
65%
-85
- C1 -
1SIQ
1
GCDH_HUMAN
A:
[2-388]
------
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
--
F
H
-
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
---
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
--
S
-
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
--
E
D
---
G
---
C
-----
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
100
HHSearch
89.87
66%
-84
- C1 -
1SIQ
1
GCDH_HUMAN
A:
[2-388]
------
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
--
F
H
-
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
K
-
G
Y
G
C
A
G
V
---
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
--
H
Y
NS
S
-
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
--
E
D
---
G
---
C
-----
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
9
PsiBlast_PDB
89.70
65%
-87
- C1 -
2R0N
2
GCDH_HUMAN
A:
[3-390]
-----
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
--
F
H
-
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
---
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
--
S
-
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
--
E
D
---
G
---
C
-----
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
10
PsiBlast_PDB
88.42
65%
-84
- C1 -
2R0M
2
GCDH_HUMAN
A:
[3-390]
-----
E
F
D
W
Q
D
P
L
V
L
E
E
Q
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
R
I
L
L
A
N
R
N
-
E
V
--
F
H
-
R
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
-
K
G
Y
G
C
A
G
V
---
S
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
R
S
A
M
S
V
Q
S
S
L
V
M
H
P
I
Y
A
Y
G
S
E
E
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
G
L
T
E
P
N
S
G
S
D
P
S
S
M
E
T
R
A
H
Y
N
S
--
S
-
N
K
S
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
F
V
V
W
A
R
C
--
E
D
---
G
---
C
-----
I
R
G
F
L
L
E
K
G
M
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
S
A
T
G
M
I
I
M
D
G
V
E
V
P
E
E
N
V
L
-
P
G
A
-
S
S
L
G
G
P
F
G
C
L
N
N
A
R
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
I
T
L
G
L
H
A
C
L
Q
L
G
R
L
K
D
Q
D
K
A
A
P
E
M
V
S
L
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
D
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
I
Q
A
F
T
103
HHSearch
83.04
45%
-81
- C1 -
3SF6
17
?
A:
[17-402]
-----
R
R
G
A
D
D
L
I
G
I
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
D
-
G
E
--
L
P
A
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
K
-
G
Y
G
C
A
G
M
---
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
G
M
R
T
R
A
--
T
R
--
S
-
G
D
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
--
D
----
E
---
G
-----
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
-
P
G
A
-
T
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
E
L
A
P
E
Q
V
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
R
12
PsiBlast_PDB
82.97
46%
-80
- C1 -
3SF6
17
?
A:
[21-402]
---------
D
D
L
I
G
I
N
A
V
L
S
A
E
E
R
E
I
R
D
T
V
R
S
V
V
Q
R
R
I
K
P
H
I
A
S
W
Y
E
D
G
E
L
--
P
A
-
R
E
L
A
V
E
L
G
E
L
G
L
L
G
M
H
L
-
K
G
Y
G
C
A
G
M
---
S
A
V
A
Y
G
L
A
C
L
E
L
E
A
G
D
S
G
I
R
S
L
V
S
V
Q
G
S
L
A
M
Y
A
I
H
A
F
G
S
D
E
Q
K
D
Q
W
L
P
D
M
A
S
G
H
R
I
G
C
F
G
L
T
E
P
D
H
G
S
D
P
A
G
M
R
T
R
A
--
T
R
--
S
-
G
D
D
W
I
L
T
G
T
K
M
W
I
T
N
G
S
V
A
D
V
A
V
V
W
A
R
T
--
D
E
---
G
---------
I
R
G
F
V
V
P
T
D
T
P
G
F
T
A
N
T
I
K
S
K
M
S
L
R
A
S
V
T
S
E
L
V
L
D
G
V
R
L
P
D
S
A
R
L
-
P
G
A
-
T
S
L
G
A
P
L
R
C
L
N
E
A
R
F
G
I
V
F
G
A
L
G
A
A
R
D
C
L
E
T
A
L
A
Y
A
C
S
R
E
Q
F
D
R
P
I
G
G
F
Q
L
T
Q
Q
K
L
A
D
M
T
L
E
Y
G
K
G
F
L
L
A
L
H
L
G
R
Q
K
D
A
G
E
L
A
P
E
Q
V
S
L
G
K
L
N
N
V
R
E
A
I
E
I
A
R
T
A
R
T
V
L
G
A
S
G
I
T
G
E
Y
P
V
M
R
H
A
N
N
L
E
S
V
L
T
Y
E
G
T
S
E
M
H
T
L
I
I
G
Q
A
L
T
G
V
G
A
F
R
17
PsiBlast_PDB
77.92
37%
-76
- C1 -
2DVL
2
?
A:
[3-368]
------------------
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
-
A
E
--
Y
P
-
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
--
R
R
--
V
-
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
--
E
K
---
G
---------
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
-
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
R
-----
54
PsiBlast_CBE
77.12
37%
-75
- C1 -
2DVL
2
?
B:
[3-368]
------------------
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
-
A
E
--
Y
P
-
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
--
R
R
--
V
-
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
--
E
K
---
G
---------
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
-
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
R
-----
89
Fugue
75.90
36%
-74
- C1 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
--------------
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
-
G
I
YD---
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
--
T
K
--
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
--
D
K
---
S
----KGNHG
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
-
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-----
16
PsiBlast_PDB
75.85
36%
-75
- C1 -
4L1F
7
?
A:
[1-376]
--------------
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
-
H
I
--
W
D
-
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
--
V
L
--
K
-
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
--
D
K
---
S
---
Q
GVHG-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
-
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
----
53
PsiBlast_CBE
75.51
36%
-74
- C1 -
4L1F
5
?
B:
[1-376]
--------------
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
-
H
I
--
W
D
-
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
--
V
L
--
K
-
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
--
D
K
---
S
---
Q
GVHG-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
-
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
----
67
PsiBlast_CBE
74.24
31%
-74
- C1 -
1JQI
4
ACADS_RAT
B:
[9-379]
-----------------
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
-
H
L
--
F
P
-
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
--
R
E
--
E
-
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
--
D
R
---
S
---
R
QNKG-
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
-
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
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--