@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1487: (2016-01-29 )
MRIAALDQGTTSTRVLVASQDGSADIQLALRHQQHHPQSGWVEHDPLELLANLQRCLEASGRVDAIGLANQGESCMAWDARSGEPLSPLIVWQDNRTTPHIERLRASGAEALVLERSGLPLDAYFSASKLGWIVEHLPAARRALKAGRLRLGTSDAWFLDRLCGTFATDVTTASRTALMNLAEGRWDPDLCALFGVPIECLPEIRDTVGHFGVIGNTPLTASVVDQQASLYGHGCRQPGDAKITFGTGAFALTLSGERIIRSPETGLLATIAWQIDGKPVYAMDGGVYDASAAVEWAGRLGLFSDFSELAGFDRPPAIERGLAFVPALSGLACPHWDRSAGAMWLGMDAGTRREDLCQALLEGVVLRSAEVIQAMDGYLKVTDRLSIDGGLARSPYFAQFLADSLQRRIVTQRFDELTAFGCAALAARGLGHELAEPRNTRTEFQPRVDAGTARRWQVRFSEAVARTRGWR
Atome Classification :
(37 SA)
.........10........20........30.-.--......40........----50.--------.-----....-----.---.-60---------.----...-----..---...70........80........90........100.......110-.........120.......130.......140.......150--.........160.-----.--.-----.--.--..170.......180.......190.....-..200...-------....210-..-----..------..------------.------..220.......230.......240.......250.......260.......270...--....-280.......290.....-.-.300-----..---.-....310.......320.......330.......340.......350.......360.......370...--....380-...--.....390.......400.......410.......420....--...430----.-----.--.....-.----440-...---......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
I
A
ALDQGTT
S
T
R
V
L
V
ASQDGSA
D
I
Q
L
A
L
R
H
-Q--QHHPQSGWVEH
D
P
L
E
L
----
L
A
N
--------
L
-----
Q
R
C
L
-----
E
---A-S----------G----RV
D
-----
A
I
---GLANQGES
C
M
A
WDARSGEPLS
P
L
I
V
W
QDNRTT
P
H
I
E
R
L
R
ASGA
E
---
A
L
V
L
ERSGLP
L
D
A
Y
F
S
A
S
K
L
G
W
I
V
E
H
L
P
A
A
R
R
A
L
KAG
R
L
R
----LGTS
D
A
W
F
L
D
R
L
C
-----
G
--
T
-----
F
--
A
--TDVT
T
A
S
R
T
A
L
M
N
L
AEGRW
D
P
D
L
C
A
L
FG
V
P
-
I
E
C
L
P
E
I
R
-------
D
T
VGH---FG-----VI------GN------------T------P
L
T
A
S
V
V
D
Q
Q
A
S
L
YGHGCRQPGD
A
K
I
T
FGT
G
A
F
A
L
T
LSG
E
R
I
IRSPET
G
L
L
A
T
I
A
W
Q
I--DG
K
P
-
V
Y
A
MDGGVY
D
A
S
A
A
V
E
W
A
-G-RLG
L
-----
F
S
---
D
-
F
S
E
L
AGFDR
P
P
A
I
ERG
L
A
F
V
P
A
L
SGLACPHWDRSAG
A
M
W
L
GMDAGT
R
R
E
D
L
C
Q
A
L
L
E
G
V
V
L
R
S
A
E
V
I
Q
A
M--DG
Y
L
K
V
--
T
D
R
--
L
SIDGGLAR
S
P
Y
F
A
Q
F
L
A
D
S
L
Q
R
R
I
V
T
Q
R
F
D
E
L
T
A
F
G
C
A
A
L
A
--
A
RGLG-----H-----E--LAEPR-N----T---RT
E
---
F
QPRVDAGT
A
R
R
W
Q
V
R
F
S
E
A
V
A
RTRGWR
17
PsiBlast_PDB
92.20
35%
-92
- C1 -
4E1J
1
GLPK_RHIME
A:
[28-516]
--
I
L
A
I
D
Q
G
T
T
S
T
R
A
I
V
F
--
D
G
N
Q
K
I
A
G
V
G
Q
K
-
E
F
K
Q
H
F
P
K
S
G
W
V
E
H
D
P
E
E
I
W
Q
T
V
V
S
T
--------
V
-----
K
E
A
I
-----
E
---
K
-
S
----------
G
ITAN
D
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
V
V
V
W
D
R
E
T
G
K
P
I
H
N
A
I
V
W
Q
D
R
R
T
A
A
F
C
D
K
L
K
K
K
G
L
E
---
K
T
F
V
K
K
T
G
L
L
L
D
P
Y
F
S
G
T
K
L
N
W
L
L
S
N
V
K
G
A
Q
V
R
A
A
K
G
E
L
C
----
F
G
T
I
D
T
F
L
I
W
R
L
T
-----
G
GE
C
-----
F
--
C
--
T
D
A
T
N
A
S
R
T
L
L
Y
N
I
A
E
N
A
W
D
D
E
L
T
E
V
L
R
V
P
-
K
E
M
L
P
E
V
K
-------
D
C
A
A
D
---
F
G
-----
V
T
------
D
P
------------
S
LFG
A
A
I
P
I
L
G
V
A
G
D
Q
Q
A
A
T
I
G
Q
A
C
F
K
P
G
M
L
K
S
T
Y
G
T
G
C
F
A
L
L
N
T
G
K
D
M
V
R
S
-
K
N
R
L
L
T
T
I
A
Y
R
L
--
D
G
E
T
-
T
Y
A
L
E
G
S
I
F
V
A
G
A
A
V
Q
W
L
---
R
D
G
L
KVI---------
T
G
S
L
A
E
S
A
D
P
---
S
Q
E
V
Y
L
V
P
A
F
T
G
L
G
A
P
H
W
D
P
D
A
R
G
A
I
F
G
M
T
R
N
T
G
P
A
E
F
A
R
A
A
L
E
A
V
C
Y
Q
T
R
D
L
L
E
A
M
--
H
K
D
W
R
------T
V
L
R
V
D
G
G
M
V
A
S
D
W
T
M
Q
R
L
S
D
L
L
D
A
P
V
D
R
P
V
I
L
E
T
T
A
L
G
V
A
W
L
A
--
G
S
R
A
G
VWPN
Q
E
-----
A
--
F
A
K
S
W
-
A
----
R
---
D
R
R
---
F
E
P
H
M
D
E
A
T
R
K
V
K
L
K
G
W
R
S
A
V
K
R
T
L
I
A
-
87
HHSearch
91.40
37%
-88
- C1 -
3WXL
2
?
A:
[8-513]
K
Y
V
G
S
I
D
Q
G
T
T
S
T
R
F
I
I
F
D
E
R
Q
R
P
V
S
V
H
Q
V
P
H
-
T
--
Q
H
T
P
H
P
G
W
L
E
H
D
P
M
E
I
----
F
R
S
--------
A
-----
C
K
C
M
-----
S
---
V
A
I
A
K
L
R
Q
K
D
ASF
R
----
K
I
E
-----
A
I
---
G
I
T
N
Q
R
E
T
T
V
A
W
D
R
V
T
K
E
P
L
C
Y
A
P
V
W
N
D
L
R
T
Y
D
I
T
K
K
V
T
A
E
L
G
G
GDS
M
F
A
S
K
I
T
G
L
P
V
S
T
Y
F
A
A
F
K
M
R
W
M
L
E
N
V
P
A
V
A
D
A
C
R
R
G
T
L
C
----
F
G
T
I
D
T
W
L
M
Y
K
L
S
-----
G
--
G
KA---
F
--
V
--
T
D
V
T
N
A
S
R
T
F
L
M
D
L
R
T
R
K
W
S
P
E
L
C
E
K
L
K
I
P
-
M
E
T
L
P
E
I
R
-------
S
N
S
E
L
---
F
G
-----
Y
V
------
E
T
DECG
V
A
A
A
L
NER
T
------
P
I
M
G
S
I
G
D
Q
Q
S
A
L
F
G
N
M
C
F
E
K
G
E
A
K
N
T
Y
G
T
G
C
F
L
L
M
N
V
G
E
E
A
R
F
S
K
-
H
G
L
L
S
T
V
G
F
Q
V
GR
D
G
P
C
-
Y
Y
A
L
E
G
A
I
A
C
A
G
A
T
V
E
W
M
-
R
R
N
M
N
L
-----
F
S
HI-
T
E
C
E
K
L
A
R
S
--
V
-
P
G
T
Q
G
I
V
F
V
P
A
F
S
G
L
L
A
P
Y
W
D
P
S
A
R
G
T
I
V
G
M
T
L
K
T
T
R
A
H
V
I
R
A
A
L
Q
A
I
A
L
Q
L
N
D
V
V
G
S
M
--
K
R
D
A
G
L
N-
L
S
S
--
L
R
V
D
G
G
L
S
K
N
G
L
L
M
E
I
Q
A
S
L
L
G
V
D
I
L
V
P
S
M
H
E
T
T
A
L
G
A
A
L
C
A
--
G
L
A
A
G
-----
V
-----
W
TS
L
E
E
V
K
-
A
V
S
R
-
R
E
N
S
W
K
T
---
V
S
P
S
G
S
A
M
E
R
E
A
M
I
A
E
W
R
E
A
L
K
R
T
K
W
A
K
2
PsiBlast_PDB
91.16
33%
-88
- C1 -
2ZF5
-
GLPK_THEKO
O:
[5-487]
--
V
L
S
L
D
E
G
T
T
S
A
R
A
I
I
F
D
R
E
S
N
I
H
G
I
G
Q
Y
E
F
-
P
--
Q
H
Y
P
R
P
G
W
V
E
H
N
P
E
E
I
----
W
D
A
--------
Q
-----
L
R
A
I
-----
K
DAI
Q
-
S
----------
A
----
R
I
E
PNQIA
A
I
---
G
V
T
N
Q
R
E
T
T
L
V
W
D
-
K
D
G
K
P
L
Y
N
A
I
V
W
Q
C
R
R
T
A
E
M
V
E
E
I
K
R
E
Y
G
----
T
M
I
K
E
K
T
G
L
V
P
D
A
Y
F
S
A
S
K
L
K
W
L
L
D
N
V
P
G
L
R
E
K
A
E
K
G
E
V
M
----
F
G
T
V
D
T
F
L
I
Y
R
L
T
-----
G
--
E
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
F
N
I
K
K
L
D
W
D
D
E
L
L
E
L
F
D
I
P
-
E
S
V
L
P
E
V
R
-------
E
S
S
E
V
---
Y
G
-----
Y
T
KKELLG
A
E
------------
I
------
P
V
S
G
D
A
G
D
Q
Q
A
A
L
F
G
Q
A
A
F
E
A
G
M
V
K
A
T
Y
G
T
G
S
F
I
L
V
N
T
D
K
M
V
L
Y
S
D
--
N
L
L
T
T
I
A
W
G
L
--
N
G
R
V
-
S
Y
A
L
E
G
S
I
F
V
T
G
A
A
V
Q
W
L
R
D
-
G
I
K
I
-----
I
K
---
H
-
A
S
E
T
E
E
L
A
T
K
L
E
S
N
E
G
V
Y
F
V
P
A
F
V
G
L
G
A
P
Y
W
D
Q
F
A
R
G
I
I
I
G
I
T
R
G
T
G
R
E
H
L
A
R
A
T
L
E
A
I
A
Y
L
T
R
D
V
V
D
E
M
--
E
K
L
V
Q
I
--
K
E
---
L
R
V
D
G
G
A
T
A
N
D
F
L
M
Q
F
Q
A
D
I
L
N
R
K
V
I
R
P
V
V
K
E
T
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
D
-----
Y
WADTR
E
--
I
A
E
L
W
-
K
----
A
---
E
R
I
---
F
E
P
K
M
D
E
K
T
R
E
R
L
Y
K
G
W
K
E
A
V
K
R
A
M
G
W
A
81
HHSearch
91.00
39%
-82
* C1 *
2DPN
-
?
A:
[3-490]
-
F
L
L
A
L
D
Q
G
T
T
S
S
R
A
I
L
F
T
L
E
G
R
P
V
A
V
A
K
R
E
F
-
R
--
Q
L
Y
P
K
P
G
W
V
E
H
D
P
L
E
I
----
W
E
T
--------
T
-----
L
W
A
A
-----
R
---
E
V
L
R
R
A
GAEA---
G
----
E
V
L
-----
A
L
---
G
I
T
N
Q
R
E
T
T
L
L
W
D
R
K
T
G
K
P
L
H
N
A
I
V
W
Q
D
R
R
T
T
P
L
C
E
A
L
R
A
K
G
L
E
---
P
L
F
R
E
R
T
G
L
L
F
D
P
Y
F
S
G
T
K
L
V
W
L
L
E
N
V
P
G
L
K
A
R
A
E
G
G
G
V
A
----
F
G
T
V
D
T
W
L
I
W
N
L
T
-----
G
--
G
K
V
---
H
--
A
--
T
D
P
T
N
A
S
R
T
L
L
F
N
L
H
T
L
A
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L
L
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G
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P
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L
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-------
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S
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G
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---
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G
-----
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------
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A
P
------
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------
P
I
R
G
V
L
G
D
Q
Q
A
A
L
F
G
Q
A
A
L
G
G
G
E
G
K
C
T
Y
G
T
G
A
F
L
L
L
N
T
G
K
R
P
V
L
S
E
-
K
G
L
L
A
T
V
A
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S
L
--
G
G
R
A
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T
Y
A
L
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G
S
L
F
V
A
G
A
A
V
G
W
L
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K
E
V
G
L
I
-----
R
E
S--
A
E
V
E
A
L
A
A
S
--
V
-
E
D
T
G
D
V
Y
F
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
T
L
L
G
L
T
R
G
T
S
R
A
H
L
A
R
A
A
L
E
G
V
A
F
Q
V
R
D
V
V
L
A
M
--
E
E
E
A
G
V
R-
L
K
V
--
L
K
A
D
G
G
M
A
Q
N
R
L
F
L
K
I
Q
A
D
L
L
G
V
P
V
A
V
P
E
V
T
E
T
T
A
L
G
A
A
L
M
A
--
G
V
G
A
G
-----
A
-----
L
S-
P
E
D
V
A
G
R
F
R
--
E
---
A
E
R
---
F
L
P
T
M
P
E
G
R
R
E
A
L
Y
R
R
W
R
E
A
V
E
R
A
K
G
W
A
83
HHSearch
90.73
33%
-88
- C1 -
3G25
9
GLPK_STAAC
A:
[6-498]
K
Y
I
L
S
I
D
Q
G
T
T
S
S
R
A
I
L
F
N
Q
K
G
E
I
A
G
V
A
Q
R
E
F
-
K
--
Q
Y
F
P
Q
S
G
W
V
E
H
D
A
N
E
I
----
W
T
S
--------
V
-----
L
A
V
M
-----
T
---
E
V
I
N
E
N
DVRA---
D
----
Q
I
A
-----
G
I
---
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
H
T
G
R
P
I
Y
H
A
I
V
W
Q
S
R
Q
T
Q
S
I
C
S
E
L
K
Q
Q
G
Y
E
---
Q
T
F
R
D
K
T
G
L
L
L
D
P
Y
F
A
G
T
K
V
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
N
G
D
L
L
----
F
G
T
I
D
T
W
L
V
W
K
L
S
-----
G
--
K
-----
A
AH
I
--
T
D
Y
S
N
A
S
R
T
L
M
F
N
I
H
D
L
E
W
D
D
E
L
L
E
L
L
T
V
P
-
K
N
M
L
P
E
V
K
-------
A
S
S
E
V
---
Y
G
-----
K
T
------
I
D
YHFYGQE-----
V
------
P
I
A
G
V
A
G
D
Q
Q
A
A
L
F
G
Q
A
C
F
E
R
G
D
V
K
N
T
Y
G
T
G
G
F
M
L
M
N
T
G
D
K
A
V
K
S
E
-
S
G
L
L
T
T
I
A
Y
G
I
--
D
G
K
V
-
N
Y
A
L
E
G
S
I
F
V
S
G
S
A
I
Q
W
L
-
R
D
G
L
R
M
-----
I
N
SA-
P
Q
S
E
S
Y
A
T
R
--
V
-
D
S
T
E
G
V
Y
V
V
P
A
F
V
G
L
G
T
P
Y
W
D
S
E
A
R
G
A
I
F
G
L
T
R
G
T
E
K
E
H
F
I
R
A
T
L
E
S
L
C
Y
Q
T
R
D
V
M
E
A
M
--
S
K
D
S
G
I
D-
V
Q
S
--
L
R
V
D
G
G
A
V
K
N
N
F
I
M
Q
F
Q
A
D
I
V
N
T
S
V
E
R
P
E
I
Q
E
T
T
A
L
G
A
A
F
L
A
--
G
L
A
V
G
-----
F
-----
W
ES
K
D
D
I
A
-
K
N
WK-
L
---
E
E
K
---
F
D
P
K
M
D
E
G
E
R
E
K
L
Y
R
G
W
K
K
A
V
E
A
T
Q
V
F
K
1
PsiBlast_PDB
90.14
38%
-81
- C1 -
2DPN
-
?
A:
[4-491]
--
L
L
A
L
D
Q
G
T
T
S
S
R
A
I
L
F
T
L
E
G
R
P
V
A
V
A
K
R
E
F
-
R
--
Q
L
Y
P
K
P
G
W
V
E
H
D
P
L
E
I
----
W
E
T
T
L
W
A
A
R
E
V
L
-----
R
R
A
G
-----
A
---
E
-
A
----------
G
----
E
V
L
-----
A
L
---
G
I
T
N
Q
R
E
T
T
L
L
W
D
R
K
T
G
K
P
L
H
N
A
I
V
W
Q
D
R
R
T
T
P
L
C
E
A
L
R
A
K
G
L
E
---
P
L
F
R
E
R
T
G
L
L
F
D
P
Y
F
S
G
T
K
L
V
W
L
L
E
N
V
P
G
L
K
A
R
A
E
G
G
G
V
A
----
F
G
T
V
D
T
W
L
I
W
N
L
T
-----
G
GK
V
-----
H
--
A
--
T
D
P
T
N
A
S
R
T
L
L
F
N
L
H
T
L
A
W
D
P
E
L
L
E
A
L
G
I
P
-
A
A
L
L
P
E
V
R
-------
P
S
D
G
D
---
F
G
ETLPE
L
L
------
G
A
P
-----------
V
------
P
I
R
G
V
L
G
D
Q
Q
A
A
L
F
G
Q
A
A
L
G
G
G
E
G
K
C
T
Y
G
T
G
A
F
L
L
L
N
T
G
K
R
P
V
L
S
-
E
K
G
L
L
A
T
V
A
W
S
L
--
G
G
R
A
-
T
Y
A
L
E
G
S
L
F
V
A
G
A
A
V
G
W
L
-
K
-
E
V
G
L
-----
I
R
---
E
-
S
A
E
V
E
A
L
A
A
S
V
E
D
T
G
D
V
Y
F
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
T
L
L
G
L
T
R
G
T
S
R
A
H
L
A
R
A
A
L
E
G
V
A
F
Q
V
R
D
V
V
L
A
M
--
E
E
E
A
G
V
--
R
L
K
V
-
L
K
A
D
G
G
M
A
Q
N
R
L
F
L
K
I
Q
A
D
L
L
G
V
P
V
A
V
P
E
V
T
E
T
T
A
L
G
A
A
L
M
A
--
G
V
G
A
G
ALS
P
-
E
-----
D
--
V
A
G
R
F
-
R
----
E
---
A
E
R
---
F
L
P
T
M
P
E
G
R
R
E
A
L
Y
R
R
W
R
E
A
V
E
R
A
K
G
W
A
77
HHSearch
89.62
35%
-83
- C1 -
2ZF5
-
GLPK_THEKO
O:
[3-488]
K
F
V
L
S
L
D
E
G
T
T
S
A
R
A
I
I
F
D
R
E
S
N
I
H
G
I
G
Q
Y
E
F
-
P
--
Q
H
Y
P
R
P
G
W
V
E
H
N
P
E
E
I
----
W
D
A
--------
Q
-----
L
R
A
I
-----
K
---
D
A
I
QSARIEP---
N
----
Q
I
A
-----
A
I
---
G
V
T
N
Q
R
E
T
T
L
V
W
D
K
-
D
G
K
P
L
Y
N
A
I
V
W
Q
C
R
R
T
A
E
M
V
E
E
I
K
R
E
Y
G
----
T
M
I
K
E
K
T
G
L
V
P
D
A
Y
F
S
A
S
K
L
K
W
L
L
D
N
V
P
G
L
R
E
K
A
----
E
K
GEVM
F
G
T
V
D
T
F
L
I
Y
R
L
T
-----
G
--
E
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
F
N
I
K
K
L
D
W
D
D
E
L
L
E
L
F
D
I
P
-
E
S
V
L
P
E
V
R
-------
E
S
S
E
V
---
Y
G
-----
Y
T
------
K
K
ELLGAE------
I
------
P
V
S
G
D
A
G
D
Q
Q
A
A
L
F
G
Q
A
A
F
E
A
G
M
V
K
A
T
Y
G
T
G
S
F
I
L
V
N
T
D
K
-
M
V
L
Y
S
-
D
N
L
L
T
T
I
A
W
G
L
--
N
G
R
V
-
S
Y
A
L
E
G
S
I
F
V
T
G
A
A
V
Q
W
L
-
R
D
G
I
K
I
-----
I
K
HA-
S
E
T
E
E
L
A
T
K
--
L
-
E
S
N
E
G
V
Y
F
V
P
A
F
V
G
L
G
A
P
Y
W
D
Q
F
A
R
G
I
I
I
G
I
T
R
G
T
G
R
E
H
L
A
R
A
T
L
E
A
I
A
Y
L
T
R
D
V
V
D
E
M
--
E
K
L
-
V
Q
--
I
K
E
--
L
R
V
D
G
G
A
T
A
N
D
F
L
M
Q
F
Q
A
D
I
L
N
R
K
V
I
R
P
V
V
K
E
T
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
D
-----
Y
-----
W
AD
T
R
E
I
A
-
E
LWK-
A
---
E
R
I
---
F
E
P
K
M
D
E
K
T
R
E
R
L
Y
K
G
W
K
E
A
V
K
R
A
M
G
W
A
72
PsiBlast_CBE
89.09
32%
-84
- C1 -
3FLC
2
GLPK_ENTCA
O:
[19-510]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
AGAFI
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
AGI
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
SNS----
E
V
Y
G
H
TRS
Y
R
-----
F
Y
------
G
S
E-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
--
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
-
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
KK
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
GL
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
GQM
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
86
HHSearch
89.00
35%
-84
- C1 -
2D4W
3
?
A:
[2-497]
D
Y
V
L
A
I
D
Q
G
T
T
S
S
R
A
I
V
F
D
H
S
G
E
I
Y
S
T
G
Q
L
E
H
-
D
--
Q
I
F
P
R
A
G
W
V
E
H
N
P
E
Q
I
----
W
N
N
--------
V
-----
R
E
V
V
-----
G
---
L
A
L
T
R
G
NLTH---
E
----
D
I
A
-----
A
V
---
G
I
T
N
Q
R
E
T
A
V
V
W
D
K
T
T
G
K
P
V
Y
N
A
I
V
W
Q
D
T
R
T
Q
K
I
V
D
E
L
G
G
D
E
G
A
---
E
K
Y
K
S
I
V
G
L
P
L
A
T
Y
F
S
G
P
K
I
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
K
G
D
L
L
----
F
G
N
T
D
T
W
V
L
W
N
M
T
-----
G
--
G
TEG
G
V
H
--
V
--
T
D
V
T
N
A
S
R
T
M
L
M
D
L
D
T
L
S
W
R
E
D
I
A
A
D
M
G
I
P
-
L
S
M
L
P
D
I
R
-------
S
S
S
E
V
---
Y
G
-----
H
G
------
R
P
RGLVPG------
V
------
P
I
A
G
I
L
G
D
Q
Q
A
A
T
F
G
Q
A
C
F
E
V
G
Q
A
K
N
T
Y
G
T
G
N
F
L
L
L
N
T
G
T
E
K
V
M
S
K
-
N
G
L
L
T
T
V
C
Y
K
I
G-
D
A
P
A
-
V
Y
A
L
E
G
S
I
A
V
T
G
S
L
V
Q
W
L
-
R
D
N
L
G
M
-----
F
E
DA-
P
D
V
E
W
L
A
G
K
--
V
-
Q
D
N
G
G
A
Y
F
V
P
A
F
S
G
L
F
A
P
Y
W
R
P
D
A
R
G
A
L
V
G
L
T
R
Y
V
N
R
N
H
I
A
R
A
A
L
E
A
T
A
F
Q
S
R
E
V
V
D
A
M
--
N
A
D
S
G
V
D-
L
T
E
--
L
R
V
D
G
G
M
V
A
N
E
L
L
M
Q
F
Q
A
D
Q
L
G
V
D
V
V
R
P
K
V
A
E
T
T
A
L
G
A
A
Y
A
A
--
G
I
A
V
G
-----
F
-----
W
KG
E
Q
D
V
I
D
N
WA--
E
---
D
K
R
---
W
S
P
S
M
E
S
G
E
R
E
R
L
Y
R
N
W
K
K
A
V
T
K
T
M
E
W
V
18
PsiBlast_PDB
88.56
32%
-86
- C1 -
3G25
9
GLPK_STAAC
A:
[8-496]
--
I
L
S
I
D
Q
G
T
T
S
S
R
A
I
L
F
N
Q
K
G
E
I
A
G
V
A
Q
R
E
F
-
K
--
Q
Y
F
P
Q
S
G
W
V
E
H
D
A
N
E
I
----
W
T
S
--------
V
L
A
V
M
T
E
V
I
N
-----
E
---
N
-
D
----------
V
----
R
A
D
QIA--
G
I
---
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
H
T
G
R
P
I
Y
H
A
I
V
W
Q
S
R
Q
T
Q
S
I
C
S
E
L
K
Q
Q
G
Y
E
---
Q
T
F
R
D
K
T
G
L
L
L
D
P
Y
F
A
G
T
K
V
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
N
G
D
L
L
----
F
G
T
I
D
T
W
L
V
W
K
L
S
-----
G
--
K
-----
A
--
A
HI
T
D
Y
S
N
A
S
R
T
L
M
F
N
I
H
D
L
E
W
D
D
E
L
L
E
L
L
T
V
P
-
K
N
M
L
P
E
V
K
A
SSEVYG
K
T
I
D
Y
---
H
F
-----
Y
G
------
Q
E
------------
V
------
P
I
A
G
V
A
G
D
Q
Q
A
A
L
F
G
Q
A
C
F
E
R
G
D
V
K
N
T
Y
G
T
G
G
F
M
L
M
N
T
G
D
K
A
V
K
S
-
E
S
G
L
L
T
T
I
A
Y
G
I
--
D
G
K
V
-
N
Y
A
L
E
G
S
I
F
V
S
G
S
A
I
Q
W
L
---
R
D
G
L
RM---
I
N
---
S
-
A
P
Q
S
E
S
Y
A
T
R
V
D
S
T
E
G
V
Y
V
V
P
A
F
V
G
L
G
T
P
Y
W
D
S
E
A
R
G
A
I
F
G
L
T
R
G
T
E
K
E
H
F
I
R
A
T
L
E
S
L
C
Y
Q
T
R
D
V
M
E
A
M
S
K
D
S
G
I
D
V
---
Q
S
--
L
R
V
D
G
G
A
V
K
N
N
F
I
M
Q
F
Q
A
D
I
V
N
T
S
V
E
R
P
E
I
Q
E
T
T
A
L
G
A
A
F
L
A
--
G
L
A
V
G
-----
F
WESK
D
D
--
I
A
K
N
W
-
K
----
L
---
E
E
K
---
F
D
P
K
M
D
E
G
E
R
E
K
L
Y
R
G
W
K
K
A
V
E
A
T
Q
V
F
K
79
HHSearch
88.48
34%
-86
- C1 -
3EZW
5
GLPK_ECOLI
A:
[4-496]
K
Y
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
I
S
V
S
Q
R
E
F
-
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
--------
Q
-----
S
S
T
L
-----
V
---
E
V
L
A
K
A
DISS---
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
--
G
RV---
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
-------
R
S
S
E
V
---
Y
G
-----
Q
T
------
N
I
DGKGGTR-----
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
E
-
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
-
R
D
E
M
K
L
-----
I
N
DAY
D
-
S
E
Y
F
A
T
K
--
V
-
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
--
Q
A
D
S
G
I
R-
L
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
-----
W
QN
L
D
E
L
Q
E
K
AV--
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
60
PsiBlast_CBE
88.18
32%
-84
- C1 -
3H46
3
GLPK_ENTCA
O:
[7-498]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
AGAFI
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
AGI
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
SNS----
E
V
Y
G
H
TRS
Y
E
-----
F
Y
------
G
S
E-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
-
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
KK
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
GL
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
GQM
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
84
HHSearch
87.94
30%
-81
- C1 -
2W40
11
?
A:
[4-500]
N
V
I
L
S
I
D
Q
S
T
Q
S
T
K
V
F
F
Y
D
E
E
L
N
I
V
H
S
N
N
L
N
H
-
E
--
Q
K
C
L
K
P
G
W
Y
E
H
D
P
I
E
I
----
M
T
N
--------
L
-----
Y
N
L
M
-----
N
---
E
G
I
K
V
L
K
D
K
Y
TS-
V
----
I
I
K
-----
C
I
---
G
I
T
N
Q
R
E
T
V
I
I
W
D
R
I
T
G
K
P
L
Y
N
A
I
V
W
L
D
T
R
V
E
E
L
V
T
E
F
S
A
K
Y
N
N
---
N
D
I
Q
K
K
T
G
T
Y
F
N
T
Y
F
S
A
F
K
I
L
W
L
I
Q
N
N
P
E
I
K
Q
K
I
D
D
G
T
A
V
----
I
G
N
I
N
T
W
L
I
F
N
L
T
-----
K
--
G
N
----
C
--
Y
--
T
D
V
T
N
A
S
R
T
L
L
M
D
I
N
T
L
Q
W
D
E
K
M
C
K
I
F
N
I
T
N
M
S
V
L
P
E
I
K
-------
S
N
C
S
N
---
F
G
-----
L
V
------
K
S
EHVPDYLN----
I
------
P
I
T
G
C
I
G
D
Q
Q
S
A
C
I
G
Q
A
I
F
D
E
G
E
A
K
C
T
Y
G
T
G
V
F
L
L
I
N
T
G
E
-
K
V
V
Y
S
T
C
G
L
I
T
T
I
C
Y
K
F
ND
N
D
K
P
-
K
Y
A
L
E
G
S
I
G
T
A
G
S
G
V
S
W
L
-
L
K
N
K
L
I
-----
D
D
P--
S
E
A
S
D
I
M
E
K
--
C
-
E
N
T
T
G
V
I
F
V
P
A
F
S
G
L
Y
A
P
R
W
R
S
D
A
R
A
S
I
Y
G
M
T
F
N
T
E
R
S
H
I
V
R
A
L
L
E
G
I
A
F
Q
L
N
E
I
V
D
S
L
--
T
S
D
M
G
I
EM
L
H
V
--
L
R
C
D
G
G
M
T
K
N
K
P
F
M
Q
F
N
S
D
I
I
N
T
K
I
E
V
S
K
Y
K
E
V
T
S
L
G
A
A
V
L
A
--
G
L
E
V
K
-----
I
-----
W
DS
L
D
S
V
K
-
S
L
L
R
R
S
---
D
A
V
---
F
H
S
K
M
D
D
K
K
R
K
K
K
T
S
E
W
N
K
A
V
E
R
T
L
I
Q
L
70
PsiBlast_CBE
87.89
32%
-84
- C1 -
3H3N
6
GLPK_ENTCA
O:
[7-498]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
AGAFI
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
AGI
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
SNS----
E
V
Y
G
H
TRS
Y
R
-----
F
Y
------
G
S
E-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
-
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
KK
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
GL
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
GQM
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
58
PsiBlast_CBE
87.83
32%
-83
- C1 -
3D7E
1
GLPK_ENTCA
O:
[6-497]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
AGAFI
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
AGI
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
SNS----
E
V
Y
G
H
TRS
Y
A
-----
F
Y
------
G
S
E-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
-
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
KK
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
GL
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
GQM
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
32
PsiBlast_CBE
87.55
33%
-90
- C1 -
3EZW
12
GLPK_ECOLI
H:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
---------R-----------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
33
PsiBlast_CBE
87.32
33%
-87
- C1 -
3EZW
7
GLPK_ECOLI
G:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
Q
S
S
T
L
V
E
V
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
R
SS----
E
V
Y
G
Q
---
T
N
-----
I
D
------
G
K
G
G
T
R
--------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
Q
A
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNL
D
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
62
PsiBlast_CBE
87.30
32%
-84
- C1 -
3H45
3
GLPK_ENTCA
O:
[7-498]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
AGAFI
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
AGI
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
SNS----
E
V
Y
G
H
TRS
Y
E
-----
F
Y
------
G
S
E-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
-
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
KK
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
GL
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
GQM
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
4
PsiBlast_PDB
87.30
33%
-87
- C1 -
3EZW
5
GLPK_ECOLI
A:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
Q
S
S
T
L
V
E
V
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
R
SS----
E
V
Y
G
Q
---
T
N
-----
I
D
------
G
K
GGTR--------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
Q
A
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
68
PsiBlast_CBE
87.09
32%
-84
- C1 -
3H3O
4
GLPK_ENTCA
B:
[7-498]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
A
G
A
F
I
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
S
NS----
E
V
Y
G
H
T
R
S
Y
R
-----
F
Y
------
G
S
E
-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
-
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
39
PsiBlast_CBE
86.79
33%
-88
- C1 -
1GLL
3
GLPK_ECOLI
O:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSWTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
--------TR----------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
41
PsiBlast_CBE
86.36
33%
-86
- C1 -
1BWF
2
GLPK_ECOLI
O:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSWTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
--------TR----------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
6
PsiBlast_PDB
86.10
33%
-86
- C1 -
1GLJ
3
GLPK_ECOLI
Y:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSWTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
--------TR----------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
49
PsiBlast_CBE
86.01
33%
-86
- C1 -
1BO5
1
GLPK_ECOLI
Z:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
------
G
K
GGTR--------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
40
PsiBlast_CBE
85.98
33%
-87
- C1 -
1GLJ
2
GLPK_ECOLI
O:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSWTLVEV
L
-----
A
K
A
D
-----
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---
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-
S
----------
D
----
Q
I
A
-----
A
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---
G
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T
I
V
W
E
K
E
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G
K
P
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Y
N
A
I
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W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
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V
K
W
I
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G
S
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A
R
R
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L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
--------TR----------
I
------
P
I
S
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A
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D
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A
L
F
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N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
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Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
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R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
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T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
15
PsiBlast_PDB
85.78
33%
-81
- C1 -
1BOT
2
GLPK_ECOLI
O:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
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N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
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D
H
V
E
G
S
R
E
R
A
R
R
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L
L
----
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D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
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V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
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R
E
M
L
P
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RSS----
E
V
Y
G
Q
---
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N
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G
------
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T
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--
T
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Y
A
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A
V
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D
-
E
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L
-----
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N
---
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T
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L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
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R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
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V
----
I
---
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R
E
---
F
R
P
G
I
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T
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N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
13
PsiBlast_PDB
85.49
33%
-84
- C1 -
1GLE
4
GLPK_ECOLI
G:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
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H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
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---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
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R
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T
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W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
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T
K
V
K
W
I
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D
H
V
E
G
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R
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R
A
R
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L
L
----
F
G
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V
D
T
W
L
I
W
K
M
T
-----
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GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
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RSS----
E
V
Y
G
Q
---
T
N
-----
I
---------------------
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T
Y
G
T
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C
F
M
L
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A
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-
E
N
G
L
L
T
T
I
A
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--
T
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-
N
Y
A
L
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G
A
V
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D
-
E
M
K
L
-----
I
N
---
D
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A
Y
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V
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G
V
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L
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A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
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D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
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V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
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R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
16
PsiBlast_PDB
85.31
33%
-83
- C1 -
1BO5
2
GLPK_ECOLI
O:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
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H
D
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M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
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---
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-
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----------
D
----
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I
A
-----
A
I
---
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W
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K
E
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G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
------
G
K
GGTR--------
I
------
P
I
S
G
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A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
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M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
56
PsiBlast_CBE
85.10
32%
-83
- C1 -
2D4W
3
?
A:
[4-497]
--
V
L
A
I
D
Q
G
T
T
S
S
R
A
I
V
F
D
H
S
G
E
I
Y
S
T
G
Q
L
E
H
-
D
--
Q
I
F
P
R
A
G
W
V
E
H
N
P
E
Q
I
----
W
N
N
V
R
E
V
V
G
L
A
L
-----
T
R
G
N
-----
L
---
T
-
H
----------
E
----
D
I
A
-----
A
V
---
G
I
T
N
Q
R
E
T
A
V
V
W
D
K
T
T
G
K
P
V
Y
N
A
I
V
W
Q
D
T
R
T
Q
K
I
V
D
E
L
G
G
D
E
G
A
---
E
K
Y
K
S
I
V
G
L
P
L
A
T
Y
F
S
G
P
K
I
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
K
G
D
L
L
----
F
G
N
T
D
T
W
V
L
W
N
M
T
GGTEG
G
--
V
-----
H
--
V
--
T
D
V
T
N
A
S
R
T
M
L
M
D
L
D
T
L
S
W
R
E
D
I
A
A
D
M
G
I
P
-
L
S
M
L
P
D
I
R
S
SS----
E
V
Y
G
H
GRP
R
G
-----
L
V
------
P
G
------------
V
------
P
I
A
G
I
L
G
D
Q
Q
A
A
T
F
G
Q
A
C
F
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V
G
Q
A
K
N
T
Y
G
T
G
N
F
L
L
L
N
T
G
T
E
K
V
M
S
-
K
N
G
L
L
T
T
V
C
Y
K
I
--
G
D
A
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A
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Y
A
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E
G
S
I
A
V
T
G
S
L
V
Q
W
L
R
D
-
N
L
G
M
-----
F
E
---
D
-
A
P
D
V
E
W
L
A
G
K
V
Q
D
N
G
G
A
Y
F
V
P
A
F
S
G
L
F
A
P
Y
W
R
P
D
A
R
G
A
L
V
G
L
T
R
Y
V
N
R
N
H
I
A
R
A
A
L
E
A
T
A
F
Q
S
R
E
V
V
D
A
M
N
A
D
S
G
V
D
L
--
T
E
---
L
R
V
D
G
G
M
V
A
N
E
L
L
M
Q
F
Q
A
D
Q
L
G
V
D
V
V
R
P
K
V
A
E
T
T
A
L
G
A
A
Y
A
A
--
G
I
A
V
G
FWKG
E
Q
-----
D
--
V
I
D
N
W
-
A
----
E
---
D
K
R
---
W
S
P
S
M
E
S
G
E
R
E
R
L
Y
R
N
W
K
K
A
V
T
K
T
M
E
W
V
7
PsiBlast_PDB
84.90
33%
-84
- C1 -
1GLL
3
GLPK_ECOLI
Y:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSWTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
--------TR----------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
11
PsiBlast_PDB
84.70
33%
-83
- C1 -
1GLC
4
GLPK_ECOLI
G:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
---------------------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
5
PsiBlast_PDB
84.63
33%
-84
- C1 -
1BWF
3
GLPK_ECOLI
Y:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSWTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
--------TR----------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
12
PsiBlast_PDB
84.50
33%
-84
- C1 -
1GLD
3
GLPK_ECOLI
G:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
---------------------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
9
PsiBlast_PDB
84.49
33%
-84
- C1 -
1GLA
1
GLPK_ECOLI
G:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
---------------------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
48
PsiBlast_CBE
84.47
33%
-85
- C1 -
1BOT
1
GLPK_ECOLI
Z:
[6-496]
--
I
V
A
L
D
Q
G
T
T
S
S
R
A
V
V
M
D
H
D
A
N
I
-
I
S
V
S
Q
R
E
F
E
--
Q
I
Y
P
K
P
G
W
V
E
H
D
P
M
E
I
----
W
A
T
QSSTLVEV
L
-----
A
K
A
D
-----
I
---
S
-
S
----------
D
----
Q
I
A
-----
A
I
---
G
I
T
N
Q
R
E
T
T
I
V
W
E
K
E
T
G
K
P
I
Y
N
A
I
V
W
Q
C
R
R
T
A
E
I
C
E
H
L
K
R
D
G
L
E
---
D
Y
I
R
S
N
T
G
L
V
I
D
P
Y
F
S
G
T
K
V
K
W
I
L
D
H
V
E
G
S
R
E
R
A
R
R
G
E
L
L
----
F
G
T
V
D
T
W
L
I
W
K
M
T
-----
Q
GR
V
-----
H
--
V
--
T
D
Y
T
N
A
S
R
T
M
L
F
N
I
H
T
L
D
W
D
D
K
M
L
E
V
L
D
I
P
-
R
E
M
L
P
E
V
R
RSS----
E
V
Y
G
Q
---
T
N
-----
I
G
------
G
K
GGTR--------
I
------
P
I
S
G
I
A
G
D
Q
Q
A
A
L
F
G
Q
L
C
V
K
E
G
M
A
K
N
T
Y
G
T
G
C
F
M
L
M
N
T
G
E
K
A
V
K
S
-
E
N
G
L
L
T
T
I
A
C
G
P
--
T
G
E
V
-
N
Y
A
L
E
G
A
V
F
M
A
G
A
S
I
Q
W
L
R
D
-
E
M
K
L
-----
I
N
---
D
-
A
Y
D
S
E
Y
F
A
T
K
V
Q
N
T
N
G
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
P
Y
A
R
G
A
I
F
G
L
T
R
G
V
N
A
N
H
I
I
R
A
T
L
E
S
I
A
Y
Q
T
R
D
V
L
E
A
M
QA
D
S
G
I
R
L
---
H
A
--
L
R
V
D
G
G
A
V
A
N
N
F
L
M
Q
F
Q
S
D
I
L
G
T
R
V
E
R
P
E
V
R
E
V
T
A
L
G
A
A
Y
L
A
--
G
L
A
V
G
-----
F
WQNLD
E
--
L
Q
E
K
A
-
V
----
I
---
E
R
E
---
F
R
P
G
I
E
T
T
E
R
N
Y
R
Y
A
G
W
K
K
A
V
K
R
A
M
A
W
E
55
PsiBlast_CBE
84.19
32%
-82
- C1 -
2D4W
3
?
B:
[4-497]
--
V
L
A
I
D
Q
G
T
T
S
S
R
A
I
V
F
D
H
S
G
E
I
Y
S
T
G
Q
L
E
H
-
D
--
Q
I
F
P
R
A
G
W
V
E
H
N
P
E
Q
I
----
W
N
N
VREVVGLA
L
-----
T
R
G
N
-----
L
---
T
-
H
----------
E
----
D
I
A
-----
A
V
---
G
I
T
N
Q
R
E
T
A
V
V
W
D
K
T
T
G
K
P
V
Y
N
A
I
V
W
Q
D
T
R
T
Q
K
I
V
D
E
L
G
G
D
E
G
A
---
E
K
Y
K
S
I
V
G
L
P
L
A
T
Y
F
S
G
P
K
I
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
K
G
D
L
L
----
F
G
N
T
D
T
W
V
L
W
N
M
T
GGTEG
G
--
V
-----
H
--
V
--
T
D
V
T
N
A
S
R
T
M
L
M
D
L
D
T
L
S
W
R
E
D
I
A
A
D
M
G
I
P
-
L
S
M
L
P
D
I
R
SSS----
E
V
Y
G
H
GRP
R
G
-----
L
V
------
P
G
------------
V
------
P
I
A
G
I
L
G
D
Q
Q
A
A
T
F
G
Q
A
C
F
E
V
G
Q
A
K
N
T
Y
G
T
G
N
F
L
L
L
N
T
G
T
E
K
V
M
S
-
K
N
G
L
L
T
T
V
C
Y
K
I
--
G
D
A
P
A
V
Y
A
L
E
G
S
I
A
V
T
G
S
L
V
Q
W
L
R
D
-
N
L
G
M
-----
F
E
---
D
-
A
P
D
V
E
W
L
A
G
K
V
Q
D
N
G
G
A
Y
F
V
P
A
F
S
G
L
F
A
P
Y
W
R
P
D
A
R
G
A
L
V
G
L
T
R
Y
V
N
R
N
H
I
A
R
A
A
L
E
A
T
A
F
Q
S
R
E
V
V
D
A
M
NA
D
S
G
V
D
L
--
T
E
---
L
R
V
D
G
G
M
V
A
N
E
L
L
M
Q
F
Q
A
D
Q
L
G
V
D
V
V
R
P
K
V
A
E
T
T
A
L
G
A
A
Y
A
A
--
G
I
A
V
G
FWKGE
Q
-----
D
--
V
I
D
N
W
-
A
----
E
---
D
K
R
---
W
S
P
S
M
E
S
G
E
R
E
R
L
Y
R
N
W
K
K
A
V
T
K
T
M
E
W
V
74
PsiBlast_CBE
77.48
33%
-72
- C1 -
1XUP
1
GLPK_ENTCA
O:
[2-472]
--
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
-
P
--
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
----
W
N
S
--------
V
-----
Q
S
V
I
AGAFI
E
---
S
-
G
----------
I
----
R
P
E
-----
A
I
AGI
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
---
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
----
F
G
T
I
D
S
W
L
V
W
K
L
T
-----
D
GQ
V
-----
H
--
V
--
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
-
S
S
M
L
P
E
V
K
SNS----
E
V
Y
G
H
TRS
Y
H
-----
F
Y
------
G
S
E-----------
V
------
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
-
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
G
K
V
-
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
---
R
D
G
L
RMIET
S
P
---
Q
-
S
E
E
L
A
A
K
A
K
G
---
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
KK
D
S
G
I
D
I
--
P
-
L
--
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
GL
A
V
G
F
W
-----
K
-----
D
--
L
D
E
L
K
-
S
----
M
---
A
E
E
GQM
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
------