@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1779: (2016-02-01 )
MSTDSPLRTTASTCCYCGVGCGVLIEHDGERILGVQGDPRHPANFGRLCSKGASLHLTGDLQARALYPQLRLGKQLARARSDWESALEHAAGRFAETIREHGPDSVAFYISGQLLTEDYYAFNKLARALVGTNNIDSNSRLCMSSAVVGYKRSLGADAPPCSYEDLDCADCVLIAGSNMAFAHPVLFRRLEAAKAARPEMRIVVIDPRRTDTCELADLHLALLPGTDVALFHGILHILLWEDWIDRSFIAEHTEGFADLKELVRDYTPAAVADICGIDRADLQRCAEWIGRSPRFLSLWCMGLNQSSAGSAKNSALINLHLATGKIGRAGCGPFSLTGQPNAMGGRETGSLANLLPGHREAADPGHRAEVAHYWGVEQLPTSPGLSAIELFDAVHDGRIKALWIACTNPAQSLPDQRKIHEALARCPFVVVQEAFAGTETCQYADLLLPAASWGEKEGSVTNSERRISHVRRAVPPPGEARQDWNIVCDFARRLEGHLRPAKPGLFAFADSRSLFDEYKLLTAGRDLDLSGLSYALLDRLGPQQWPFPTGAEQGTARLYADGRFPTASGRAQLVAEPYRAAQEKRDARYPLTLNTGRLRDQWHGMSRTGTCARLFGHEEEALVHLHPEELRRRQLLDGQLVRLKSRRGALVLPVSADDSVRPGQAFLPMHWGDRFLKGLGCNVLTLPAFDPLSKQPELKHAGVQVESVELPWRLFALVETDIQARFEALRALCEVFDHASFSLAGRERPALLVSAAHHEAPGADLLERIDRQLELLDGPILAYDDPRRAIGKRVRLEDGRIVAVRLAGETLARDWLKELWLTGRADSELRRWLLAPLGAAPGRPSQGAGGKTLCSCQNVSQQTVLGGIARGLDLDGLKREFGCGTGCGSCVPEIKRLLAAPRPMAANA
Atome Classification :
(20 SA)
-.......-----..10......--..20.......-------------------------------------------.30------------------------------------------..-.......40.--..-------.....50......-----..60.-----.......70..-----.--.--..-----.----.80------------........90........100....---..----.110--.----....-....120.......130......-----.140.......150.......160.......170.......180.....-.----------.---------.-----190--.------------.....----------..200---.........210---...---.--------.--------..220.......230.......---------240.......250-----------------------..---.----------------------------------------------------------------------.-------------------------------....260.......270.......280.....-.------.------290------.-.-.....-300.......310.......320.......330-----------.......------------.-------340..-.-.-..-.---350----------.......360-...-----.----.-..370---------------------.......--.--.380.---------------........390...---....400........410...------------------------------.----...420....----..-.--..430.......-440.......450.......460.--...---...470.......480.-......490...----------------------------------------.------.------..-------500.--------..----------------------------------..----------------------------------..-------..-------------510....---...520.--------------.--..------------.------..---530---------------........540-..---------...---...550-----------..----.----.-----.....560---------..---.....--------------.------------.570.......-----------580-----..----.------......590......-.600.......610......-.620.......630.......640......---.650......--.--..660.......670....-----------...680......--..690.---..-------------.-...700........710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MSTDSP
L
-----
R
T
T
A
S
T
C
C
YC--GV
G
C
G
V
L
I
EHD-------------------------------------------G
E
-------------------------------------------
R
I
-
L
GVQGDPRHP--
A
N
-------
F
G
R
L
C
SKG
A
S
L
H
L
-----TGDL
Q
-----
A
R
AL
Y
P
Q
L
R
L
G
-----
K
--
Q
--
L
A
-----
R
----
A
R
S
------------
D
W
E
S
A
L
E
H
A
A
G
R
F
A
E
T
I
R
EHGPD
S
V
---
A
F
----
Y
I
----S----
G
Q
L
L-
T
E
D
Y
Y
A
F
N
K
L
A
R
A
L
VGTNNIDSN-----
S
R
L
C
M
S
S
A
V
V
G
Y
K
R
SLGADAPPCSYEDLDCA
D
C
V
L
I
AGSNMA
F
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
L
E
---
A
------------
A
KAAR----------P
E
M
-----
R
I
V
V
IDPRRTDT---C
E
L
---
A
--------
D
--------
L
H
L
A
LLPGT
D
V
A
L
F
H
G
I
L
H
I
L
L
---------
W
E
D
WI
D
R
S
F
I
A
E
------------------------
H
T
---
E
----------------------------------------------------------------------
G
-------------------------------
F
A
D
L
K
E
L
V
R
DYT
P
A
A
V
A
D
I
CGI
D
R
A
D
L
Q
R
C
A
E
-
W
------I------GRS------
P
-
R
-
F
L
S
L
W
-
C
MGLNQSSAGSAKN
S
A
L
I
N
L
H
LATGKIGRAGC------------GPFSLTG------------Q-------PNAMG-G-R-ET-G---
S
L
A
----------NLLPGHREAA-DPG-----H----R-
A
E
V
-----------------------
A
HYWG
V
E
--Q--LP--T---------------SPG
L
S
A
I
E
L
F
D
A
VH---DG
R
I
K
-
A
L
W
I
A
CT
N
P
A
Q
SL
P
D
------------------------------
Q
----
R
K
I
H
--
E
A
L
A
----RC-
P
--
F
V
V
V
Q
E
A
FAGTE-TCQ
Y
A
D
LLLPAASWGEKEGSVT
N
S
--
E
R
R
---
I
S
H
V
R
RAVPPPGEARQ
D
-
W
N
I
V
C
D
F
A
R
R
L
E
----------------------------------------G------H------LR-------P--A--------KP----------------------------------
G
L
----------------------------------
F
A
-------FA-------------D
S
R
S
L
F
D
---
E
Y
K
L
LTA--------------G--RD------------L------DL---S
G
----------------
L
S
Y
A
L
L
D
RLG--PQ---------QWP---FPTG-------------AE----Q----G-----
T
A
R
L
Y
A-----------DG---RFPTA--------------S------------G
R
A
Q
L
V
A
E
P
Y
R
-----------
A
-------
A
Q
----E------KRDARY
P
L
T
LNTG
R
L
-
R
D
Q
WHGMSRT
G
T
C
A
R
L
FGHE-E
E
A
L
V
H
L
H
P
E
E
L
R
R
R
QLLDG
Q
L
V
RLKSRR
G
---
A
L
--
V
L
P
VSA--D--DSVRPGQ
A
F
LP
M
H
W
G
D
R
F
L
-----------
K
GLG-C
N
V
L
TLP--AFDPLS---KQ-------------P-ELKH-AG
V
Q
V
E
SVEL
P
W
R
L
F
A
L
V
E
T
D
I
Q
A
R
F
E
A
L
R
A
L
C
E
V
FDHA
S
F
SLAGRER
P
A
L
L
V
S
AAHHEAP
G
A
D
L
L
E
R
I
D
R
Q
L
E
LLDG
P
I
L
AYD
D
P
R
R
A
IG
K
R
V
RLEDG
R
I
V
A
V
R
LA
G
E
T
L
A
R
D
W
L
K
E
L
WLTGR
A
D
S
E
L
R
R
W
L
L
APLGAAPGRPSQGAGG
K
T
L
C
SCQNV
S
Q
Q
T
V
L
G
G
I
ARGLDLDG
L
K
R
EFGCGT
G
C
G
S
C
V
P
E
I
K
R
L
LAAPRPMAANA
101
HHSearch
90.00
38%
-68
* C3 *
2NAP
5
NAPA_DESDA
A:
[4-723]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
N
P
N
N
H
---
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
---------
N
E
E
L
D
N
P
R
F
W
Q
R
------------------------
Y
V
---
N
----------------------------------------------------------------------
F
M
D
AEGKPSD----------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
-
V
R
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
-
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
-----------------------------------------
G
------
V
------
D
---------------------
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
RGQDPCVPADH
P
D
RFF
F
Y
G
K
P
--------------
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
----------------
K
K
L
-
V
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.49
36%
-65
- C3 -
2JIQ
12
NAPA_DESDA
A:
[4-720]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
D
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.47
36%
-65
- C3 -
2JIO
5
NAPA_DESDA
A:
[4-720]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
D
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.04
36%
-67
- C3 -
2NAP
5
NAPA_DESDA
A:
[4-720]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
N
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.97
36%
-67
- C3 -
2V3V
9
NAPA_DESDA
A:
[3-720]
----
N
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
D
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.87
36%
-64
- C3 -
2V45
6
NAPA_DESDA
A:
[3-720]
----
N
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
N
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.78
36%
-66
- C3 -
2JIR
6
NAPA_DESDA
A:
[4-720]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
N
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDNPRF
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.74
36%
-66
- C3 -
2JIP
5
NAPA_DESDA
A:
[4-720]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
N
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
88.37
29%
-59
- C3 -
3ML1
5
NAPA_CUPNH
A:
[7-802]
--
S
E
V
T
K
L
-----
K
W
S
K
A
P
C
R
F
C
--
G
T
G
C
G
V
T
V
A
V
K
-------------------------------------------
D
N
-------------------------------------------
K
V
-
V
A
T
Q
G
D
P
Q
A
E
--
V
N
-------
K
G
L
N
C
V
K
G
Y
F
L
-----------------
S
K
I
M
Y
G
Q
D
R
L
T
-----
R
--
P
--
L
M
-----
R
----
M
K
N
GKYDKNG
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
---
G
M
----
F
G
----
S
----
G
Q
W
T
-
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
----------
T
---------
R
-----
V
T
---
D
------------
R
R
L
S
H
----------
P
K
T
-----
R
V
V
V
L
S
T
F
T
H
R
C
---
F
D
L
---
A
--------
D
--------
I
G
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
---------
R
N
N
K
V
N
K
D
F
V
N
K
------------------------
H
T
V
F
K
E
----------------------------------------------------------------------
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
T
F
D
E
F
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
------
A
------
D
P
N
------
I
-
K
-
V
M
S
L
W
-
T
M
G
F
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
------------
S
P
F
S
L
T
G
------------
Q
-------
P
S
A
C
G
T
A
-
R
-
E
V
-
G
---
T
F
S
----------
H
R
L
P
A
D
M
V
V
T
-
N
P
K
-----
H
----
R
-
E
E
A
-----------------------
E
R
I
W
K
L
P
PG
T
--
I
P
--
D
---------------
K
P
G
Y
D
A
V
L
Q
N
R
M
L
K
---
D
G
K
L
N
-
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
------------------------------
L
----
M
E
E
G
--
L
P
G
Y
----
R
N
-
P
A
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
--
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
L
W
Q
L
V
-
E
F
A
K
R
F
K
VEEVWP
P
E
L
I
A
K
K
PEYKGKT
L
Y
D
V
L
YRNGQVDKFPLKDVN
A
------
E
------
Y
H
-------
N
--
A
--------
E
A
----------------------------------
K
A
----------------------------------
F
G
-------
F
Y
-------------
L
Q
K
G
L
F
E
---
E
Y
A
T
F
G
R
--------------
G
--
H
G
------------
H
------
D
L
---
A
P
----------------
F
D
-
A
Y
H
E
A
R
G
---
L
---------
R
W
P
---
V
V
N
G
-------------
K
E
---------------
T
R
W
R
Y
R
-----------
E
G
---
S
D
P
Y
V
--------------
K
AGTGFQFYGNPD
G
K
A
V
I
F
A
L
P
Y
E
-----------
P
-------
P
A
----
E
------
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
-
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
---
R
M
--
R
S
R
I
E
T
--
R
--
G
R
D
A
P
P
R
G
L
V
F
V
P
W
F
D
--------------
A
S
Q
L
-
I
N
K
V
T
L
D
--
A
T
C
P
I
S
---
L
Q
-------------
T
-
D
F
K
K
-
C
A
V
K
I
V
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.28
36%
-65
- C3 -
2JIM
5
NAPA_DESDA
A:
[4-720]
-----
R
P
E
-----
K
W
V
K
G
V
C
R
Y
C
--
G
T
G
C
G
V
L
V
G
V
K
-------------------------------------------
D
G
-------------------------------------------
K
A
-
V
A
I
Q
G
N
P
N
N
---
H
N
-------
A
G
L
L
C
L
K
G
S
L
L
I
P
-----
V
L
N
S
K
-----
E
R
V
T
Q
P
L
V
R
R
H
-----
K
--
G
--
G
K
-----
L
----
E
P
V
------------
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
----
Y
G
----
S
----
G
Q
C
L
-
T
E
E
S
Y
V
A
N
K
I
F
K
G
G
F
G
T
N
N
V
D
G
N
-----
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
P
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
-
A
H
P
V
L
-
F
----------
R
---------
R
-----
I
A
---
R
------------
R
K
Q
V
E
----------
P
G
V
-----
K
I
I
V
A
D
P
R
R
T
N
T
---
S
R
I
---
A
--------
D
--------
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
ELDN
P
R
F
W
Q
R
Y
V
N
F
M
D
A
E
G
------------------------
K
P
---
S
----------------------------------------------------------------------
D
-------------------------------
F
E
G
Y
K
A
F
L
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
-
A
------
F
------
A
E
S
------
A
-
A
-
T
M
S
L
W
-
C
M
G
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
------------
T
S
F
S
L
T
G
------------
Q
-------
P
N
A
C
G
-
G
V
R
-
D
G
-
G
---
A
L
S
----------
H
L
L
P
A
G
R
A
I
P
-
N
A
K
-----
H
----
R
-
A
E
M
-----------------------
E
K
L
W
G
L
P
--
E
GR
I
A
--
P
---------------
E
P
G
Y
H
T
V
A
L
F
E
A
L
G
---
R
G
D
V
K
-
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
------------------------------
L
----
N
K
V
H
--
K
A
M
S
----
H
P
E
S
--
F
I
V
C
I
E
A
F
P
D
A
V
-
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
G
--
E
R
R
---
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
-
V
N
T
L
V
E
F
A
R
R
A
G
------------------------------------------------------------------
V
--------
D
P
----------------------------------
Q
L
----------------------------------
V
N
-------
F
R
-------------
N
A
E
D
V
W
N
---
E
W
R
M
V
S
K
--------------
G
--
T
T
------------
Y
------
D
F
---
W
G
----------------
M
T
R
E
R
L
R
K
E
S
--
G
L
---------
I
W
P
---
C
P
S
E
-------------
D
H
----
P
----
G
-----
T
S
L
R
Y
V
-----------
R
G
---
Q
D
P
C
V
PADHPDRFFFYGKP
D
------------
G
R
A
V
I
W
M
R
P
A
K
-----------
G
-------
A
A
----
E
------
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
M
T
G
K
V
P
E
L
Q
K
A
N
-
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
---
A
M
--
E
L
P
A
R
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
K
L
V
-----------------
N
K
L
F
L
D
--
A
T
D
P
V
S
---
R
E
-------------
P
-
E
Y
K
I
-
C
A
A
R
V
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.80
30%
-63
- C3 -
2NYA
4
NAPA_ECOLI
A:
[3-791]
-------
I
-----
K
W
D
K
A
P
C
R
F
C
--
G
T
G
C
G
V
L
V
G
T
Q
-------------------------------------------
Q
G
-------------------------------------------
R
V
-
V
A
C
Q
G
D
P
D
A
P
--
V
N
-------
R
G
L
N
C
I
K
G
Y
F
L
-----------------
P
K
I
M
Y
G
K
D
R
L
T
-----
Q
--
P
--
L
L
-----
R
----
M
K
N
GKYDKEGEF
T
P
I
T
W
D
Q
A
F
D
V
M
E
E
K
F
K
T
A
L
K
E
K
G
P
E
S
I
---
G
M
----
F
G
----
S
----
G
Q
W
T
-
I
W
E
G
Y
A
A
S
K
L
F
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
V
V
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
I
E
Q
A
D
A
F
V
L
W
G
A
N
M
A
E
-
M
H
P
I
L
-
W
----------
S
---------
R
-----
I
T
---
N
------------
R
R
L
S
N
----------
Q
N
V
-----
T
V
A
V
L
S
T
Y
Q
H
R
S
---
F
E
L
---
A
--------
D
--------
N
G
I
I
F
T
P
Q
S
D
L
V
I
L
N
Y
I
A
N
Y
I
I
---------
Q
N
N
A
I
N
Q
D
F
F
S
K
------------------------
H
V
---
N
L
R
K
G
A
T
DIGYGLRPTH
P
L
E
K
A
AKNPGSDASEPM-------------------------------------
S
-------------------------------
F
E
D
Y
K
A
F
V
A
E
Y
T
L
E
K
T
A
E
M
T
G
V
P
K
D
Q
L
E
Q
L
A
Q
L
Y
------
A
------
D
P
N
------
K
-
K
-
V
I
S
Y
W
-
T
M
G
F
N
Q
H
T
R
G
V
W
A
N
N
L
V
Y
N
L
H
L
L
T
G
K
I
S
Q
P
G
C
------------
G
P
F
S
L
T
G
------------
Q
-------
P
S
A
C
G
T
A
-
R
-
E
V
-
G
---
T
F
A
----------
H
R
L
P
A
D
M
V
V
T
-
N
E
K
-----
H
----
R
-
D
I
C
-----------------------
E
K
K
W
N
I
P
--
S
GT
I
P
--
A
---------------
K
I
G
L
H
A
V
A
Q
D
R
A
L
K
---
D
G
K
L
N
-
V
Y
W
T
M
C
T
N
N
M
Q
A
G
P
N
------------------------------
I
----
N
E
E
R
--
M
P
G
W
----
R
D
-
P
R
N
F
I
I
V
S
D
P
Y
P
-
T
V
-
S
A
L
A
A
D
L
I
L
P
T
A
M
W
V
E
K
E
G
A
Y
G
N
A
--
E
R
R
---
T
Q
F
W
R
Q
Q
V
Q
A
P
G
E
A
K
S
D
L
W
Q
L
V
-
Q
F
S
R
R
F
K
----------------------------------------
T
------
E
EVWP
E
D
L
L
-------
A
--
K
--------
K
P
----------------------------------
E
L
RGKTLYEVLYATPEVSKFPVSELAEDQLN
D
E
S
R
E
L
G
-------
F
Y
-------------
L
Q
K
G
L
F
E
---
E
Y
A
W
F
G
R
--------------
G
--
H
G
------------
H
------
D
L
---
A
------------------
P
F
D
D
Y
H
K
A
R
--
G
L
---------
R
W
P
---
V
V
N
G
-------------
K
E
---------------
T
Q
W
R
Y
S
-----------
E
G
---
N
D
P
Y
V
--------------
K
AGEGYKFYGKPD
G
K
A
V
I
F
A
L
P
F
E
-----------
P
-------
A
A
----
E
------
A
P
D
E
E
Y
D
L
W
L
S
T
G
R
V
-
L
E
H
W
H
T
G
S
M
T
R
R
V
P
E
L
H
R
A
F
-
P
E
A
V
L
F
I
H
P
L
D
A
K
A
R
D
L
R
R
G
D
K
V
K
V
V
S
R
R
G
---
E
V
--
I
S
I
V
E
T
--
R
--
G
R
N
R
P
P
Q
G
L
V
Y
M
P
F
---
F
D
-----------
A
A
Q
L
-
V
N
K
L
T
L
D
--
A
T
D
P
L
S
---
K
E
-------------
T
-
D
F
K
K
-
C
A
V
K
L
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
87.60
32%
-62
- C3 -
3ML1
5
NAPA_CUPNH
A:
[7-802]
--
S
E
V
T
K
L
-----
K
W
S
K
A
P
C
R
F
C
--
G
T
G
C
G
V
T
V
A
V
K
-------------------------------------------
D
N
-------------------------------------------
K
V
-
V
A
T
Q
G
D
P
Q
A
E
--
V
N
-------
K
G
L
N
C
V
K
G
Y
F
L
S
K
-----
I
M
Y
G
Q
-----
D
R
L
T
R
P
L
M
R
M
K
NGKYD
K
--
N
--
G
D
-----
F
----
A
P
V
------------
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
---
G
M
----
F
G
----
S
----
G
Q
W
T
-
V
W
E
G
Y
A
A
A
K
L
Y
K
A
G
F
R
S
N
N
I
D
P
N
-----
A
R
H
C
M
A
S
A
A
A
G
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
----------
T
---------
R
-----
V
T
---
D
------------
R
R
L
S
H
----------
P
K
T
-----
R
V
V
V
L
S
T
F
T
H
R
C
---
F
D
L
---
A
--------
D
--------
I
G
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
---------
R
N
N
K
V
N
K
D
F
V
N
K
------------------------
H
T
---
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
------------------------------------
T
-------------------------------
F
D
E
F
A
K
F
V
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
-
L
------
Y
------
A
D
P
------
N
I
K
-
V
M
S
L
W
-
T
M
G
F
N
Q
H
T
R
G
T
W
A
N
N
M
V
Y
N
L
H
L
L
T
G
K
I
A
T
P
G
N
------------
S
P
F
S
L
T
G
------------
Q
-------
P
S
A
C
G
-
T
-
A
R
E
V
-
G
---
T
F
S
----------
H
R
L
P
A
D
M
V
V
T
-
N
P
K
-----
H
----
R
-
E
E
A
-----------------------
E
R
I
W
K
L
P
--
P
GT
I
P
--
D
---------------
K
P
G
Y
D
A
V
L
Q
N
R
M
L
K
---
D
G
K
L
N
-
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
------------------------------------
L
M
E
--
E
G
L
P
G
Y
R
N
P
A
-
N
--
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
A
--
E
R
R
---
T
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
-
L
W
Q
L
V
E
F
A
K
R
F
-----------------------------------------
K
------
V
----------------------------
E
----------------------------------
E
V
----------------------------------
W
P
-------
P
E
L
I
A
K
K
PEYKGK--
T
L
Y
D
V
L
Y
---
R
N
G
Q
V
D
K
FPLKDVNAEYHN
A
E
A
--
K
A
------------
F
------
G
F
Y
L
Q
K
G
L
F
E
E
Y
A
T
F
G
RGHGHDL
A
P
F
D
A
Y
H
E
A
R
--
G
L
---------
R
W
P
---
V
V
N
G
-------------
K
E
----
T
----
R
WRYRE
G
S
D
P
Y
V
KAGTG------
F
Q
---
F
Y
G
N
P
--------------
D
------------
G
K
A
V
I
F
A
L
P
Y
E
-----------
P
-------
P
A
----
E
------
S
P
D
K
E
Y
P
Y
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
R
R
V
P
E
L
Y
R
S
F
-
P
N
A
V
V
F
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
---
R
M
--
R
S
R
I
E
T
--
R
GR
D
A
P
P
R
G
L
V
F
V
P
W
F
D
----------------
A
S
Q
L
-
I
N
K
V
T
L
D
--
A
T
C
P
I
S
---
L
Q
-------------
T
-
D
F
K
K
-
C
A
V
K
I
V
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.27
30%
-43
- C- -
1OGY
5
NAPA_RHOS4
A:
[12-801]
-------
I
-----
R
W
S
K
A
P
C
R
F
C
--
G
T
G
C
G
V
M
V
G
T
R
-------------------------------------------
D
G
-------------------------------------------
Q
V
-
V
A
T
H
G
D
T
Q
A
E
--
V
N
-------
R
G
L
N
C
V
K
G
Y
F
L
S
K
-----
I
M
Y
G
E
-----
D
R
L
T
T
P
L
L
R
M
K
DGVYH
K
--
E
--
G
E
-----
F
----
A
P
V
------------
S
W
D
E
A
F
D
V
M
A
A
Q
A
K
L
V
L
K
E
K
A
P
E
A
V
---
G
M
----
F
G
----
S
----
G
Q
W
T
-
I
W
E
G
Y
A
A
S
K
L
M
R
A
G
F
R
S
N
N
L
D
P
N
-----
A
R
H
C
M
A
S
A
A
T
A
F
M
R
T
F
G
M
D
E
P
M
G
C
Y
D
D
F
E
A
A
D
A
F
V
L
W
G
S
N
M
A
E
-
M
H
P
I
L
-
W
----------
S
---------
R
-----
L
T
---
D
------------
R
R
L
S
H
----------
E
H
V
-----
R
V
A
V
L
S
T
F
T
H
R
S
---
S
D
L
---
S
--------
D
--------
T
P
I
I
F
R
P
G
T
D
R
A
I
L
N
Y
I
A
H
H
I
I
---------
S
T
G
R
V
N
R
D
F
V
D
R
------------------------
H
T
---
N
F
A
L
G
ATDIGYGLRPEH
Q
L
Q
L
A
AKGAADAG
A
M
T
P
T
------------------------------------
D
-------------------------------
F
E
T
F
A
A
L
V
S
E
Y
T
L
E
K
A
A
E
I
S
G
V
E
P
A
L
L
E
E
L
A
E
-
L
------
Y
------
A
D
P
------
D
-
R
K
W
M
S
L
W
-
T
M
G
F
N
Q
H
V
R
G
V
W
A
N
H
M
V
Y
N
L
H
L
L
T
G
K
I
S
E
P
G
N
------------
S
P
F
S
L
T
G
------------
Q
-------
P
F
A
C
G
T
A
-
R
-
E
V
-
G
---
T
F
A
----------
H
R
L
P
A
D
M
V
V
T
-
N
P
E
-----
H
----
R
-
A
H
A
-----------------------
E
E
I
W
K
L
P
--
A
GL
L
P
--
D
---------------
W
V
G
A
H
A
V
E
Q
D
R
K
L
H
---
D
G
E
I
N
-
F
Y
W
V
Q
V
N
N
N
M
Q
A
A
P
N
------------------------------
I
----
D
Q
E
T
--
Y
P
G
Y
----
R
N
-
P
E
N
F
I
V
V
S
D
A
Y
P
-
T
V
-
T
G
R
A
A
D
L
V
L
P
A
A
M
W
V
E
K
E
G
A
Y
G
N
A
--
E
R
R
---
T
H
F
W
H
Q
L
V
E
A
P
G
E
A
R
S
D
-
L
W
Q
L
M
E
F
S
K
R
F
T
----------------------------------------
T
DEVWP
E
E
------
I
L
-------
S
--
A
--------
A
P
AYRGKT
L
F
E
V
L
FANGSVDRFPASDVNPDHAN
H
E
A
A
L
----------------------------------
F
G
-------
F
Y
-------------
P
Q
K
G
L
F
E
---
E
Y
A
A
F
G
R
--------------
G
--
H
G
------------
H
------
D
L
---
A
------------------
P
F
D
T
Y
H
E
V
R
--
G
L
---------
H
W
P
---
V
V
E
G
-------------
E
E
---------------
T
R
W
R
Y
R
-----------
E
G
---
F
D
P
Y
V
--------------
K
PGEGLRFYGKPD
G
R
A
V
I
L
G
V
P
Y
E
-----------
P
-------
P
A
----
E
------
S
P
D
E
E
F
G
F
W
L
V
T
G
R
V
-
L
E
H
W
H
S
G
S
M
T
L
R
W
P
E
L
Y
K
A
F
-
P
G
A
V
C
F
M
H
P
E
D
A
R
S
R
G
L
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R
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S
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V
R
V
I
S
R
R
G
---
E
I
R
T
R
L
E
T
R
G
--
R
--
N
R
M
P
R
G
V
V
F
V
P
W
-----
F
D
-----------
A
S
Q
L
-
I
N
K
V
T
L
D
--
A
N
D
P
I
S
---
R
Q
-------------
T
-
D
F
K
K
-
C
A
V
K
I
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
79.54
25%
-64
- C3 -
1G8K
5
AIOA_ALCFA
A:
[10-812]
---
P
P
A
N
A
-----
Q
R
T
N
M
T
C
H
F
C
--
I
V
G
C
G
Y
H
V
Y
K
W
-------------------------------------------
P
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
-
I
M
V
V
P
D
K
A
C
V
--
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
-----
Y
M
Y
T
P
TGDGK
E
R
L
S
A
P
R
L
Y
A
---------
A
--
D
E
-----
W
----
V
D
T
------------
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
---
F
F
----
S
C
----
F
DHGG
A
G
G
G
-
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
NRPAY
N
S
E
C
H
A
T
R
------
E
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-
F
L
N--------
H
---------
W
-----
L
P
N
L
Q
G
AT
T
S
K
K
K
E
R
F
PN
E
N
F
------------
P
Q
A
-----
R
I
I
F
V
D
P
R
E
T
P
S
---
V
A
I
---
A
R
H
V
AGNDR
V
--------
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
---------
E
Q
G
W
I
D
K
P
F
I
E
A
------------------------
H
T
---
K
----------------------------------------------------------------------
G
-------------------------------
F
D
D
A
V
K
T
-
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
-
W
------
S
------
Y
K
P
KASGQA
P
-
R
-
T
M
H
A
Y
-
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
M
G
G
------------
H
-------
Q
E
G
---
Y
-----------
T
R
----------
P
P
Y
P
G
D
----------------------------------------------------------------------------------
K
K
I
Y
I
D
Q
E
L
I
---
K
G
K
G
R
-
I
M
T
W
W
G
C
N
N
F
Q
T
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
S
A
I
V
K
Q
A
M
Q
K
ARGAT
T
E
E
M
V
----
D
V
I
Y
--
E
A
T
Q
----
N
G
G
L
--
F
V
T
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I
N
L
Y
P
-
T
K
-
L
A
E
A
A
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L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
--
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
I
A
A
R
I
A
N
A
L
-----------------------------------------
R
------
D
------
M
Y
-------
Q
--
K
D
GK
A
E
M
A
A
Q
F
----------------------------------
E
G
----------------------------------
F
D
-------
W
K
-------------
T
E
E
D
A
F
N
---
D
G
F
R
R
A
G
Q-------------
P
GA
P
A
------------
I
D
S
QGGS
T
G
---
H
L
----------------
V
T
Y
D
R
L
R
K
S
G
NN
G
V
---------
Q
L
P
---
V
V
S
W
-------------
D
E
SK
G
L
V
----
G
-----
T
E
M
L
Y
T
-----------
E
G
---
K
F
D
T
D
--------------
D
------------
G
K
A
H
F
K
P
A
P
W
N
-----------
G
-------
L
P
A
T
V
-
Q
------
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
-
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
-
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
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G
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V
Y
N
D
F
G
---
S
T
--
F
A
M
V
Y
P
--
V
--
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
V
N
----------------
G
I
-
Q
G
D
V
T
T
---
D
W
T
D
R
D
---
I
I
-------------
P
-
Y
Y
K
G
-
T
W
G
D
I
R
K
V
G
S
M
S
E
F
K
R
T
V
S
F
K
S
R
R
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Fugue
78.81
24%
-58
- C3 -
1G8K
6
AIOA_ALCFA
A:
[4-825]
--
N
D
R
I
T
L
P
P
AN
A
Q
R
T
N
M
T
C
H
F
C
--
I
V
G
C
G
Y
H
V
Y
K
W
P
EL
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
-------------------------------------------
Y
D
-
I
M
V
V
P
D
K
A
C
V
--
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
YMYTP
T
G
D
G
K
-----
E
R
L
S
A
P
R
L
Y
A
A
-----
D
--
E
--
W
V
-----
D
----
T
--------------
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
---
F
F
----
S
C
F
DHG
G
----
A
G
G
G
-
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
R
P
A
Y
N
S
E
C
H
A
T
R
E
-
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-
F
----------
L
NH
W
L
P
N
L
Q
G
A
-----
T
T
---
S
------------
K
K
K
E
R
F
PN
E
N
F
----
P
Q
A
-----
R
I
I
F
V
D
P
R
E
T
P
S
---
V
A
I
---
A
--------
R
H
V
AGNDRV
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
---------
E
Q
G
W
I
D
K
P
F
I
E
A
------------------------
H
T
---
K
----------------------------------------------------------------------
G
-------------------------------
F
D
D
A
V
K
T
N
R
-
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
-
W
------
S
YKPKAS
G
Q
A
------
P
-
R
-
T
M
H
A
Y
-
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
M
G
G
------------
H
-------
Q
E
----
G
-
Y
-
T
R
-
P
---
P
Y
P
----------
G
D
K
K
I
Y
I
D
Q
E
-
L
I
K
-----
G
----
K
-
G
R
I
-----------------------
M
T
W
W
G
C
N
--
N
--
F
Q
--
T
---------------
S
N
N
A
Q
A
L
R
E
-
A
I
L
Q
---
R
S
A
I
V
-
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
------------------------------
V
----
D
V
I
Y
--
E
A
T
Q
----
N
G
-
G
--
L
F
V
T
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
--
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-
C
L
I
A
A
R
I
A
N
A
L
R
----------------------------------------
D
------
M
------
Y
Q
K
D
GK
A
E
M
A
--
A
--------
Q
F
----------------------------------
E
G
----------------------------------
F
D
-------
W
K
-------------
T
E
E
D
A
F
N
---
D
G
F
R
R
A
G
--------------
Q
--
P
G
A
P
A
I
D
S
QGG---
S
------
T
G
---
H
L
----------------
V
T
Y
D
R
L
R
K
S
G
--
N
N
GV-------
Q
L
P
---
V
V
S
W
-------------
D
E
SK
G
L
V
----
G
-----
T
E
M
L
Y
T
-----------
E
G
---
K
F
D
T
D
--------------
D
------------
G
K
A
H
F
K
P
A
P
W
N
GLP--------
A
-------
T
V
----
Q
------
Q
Q
K
D
K
Y
R
F
W
L
N
N
G
R
N
-
N
E
V
W
Q
T
A
Y
H
D
Q
Y
N
S
L
M
Q
E
R
Y
-
P
M
A
Y
I
E
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
---
S
T
--
F
A
M
V
Y
P
--
V
--
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
V
N
G
I
-----------------
Q
G
D
V
T
T
D
--
W
T
D
R
-
D
---
I
I
-------------
P
-
Y
Y
K
G
-
T
W
G
D
I
R
K
V
G
S
M
S
E
F
K
R
T
V
S
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
R
F
G
--------------------------
14
PsiBlast_PDB
75.83
27%
-64
- C3 -
4AAY
5
?
A:
[76-790]
-------------------------------
V
V
K
Q
D
-------------------------------------------
G
--------------------------------------------
R
D
-
V
H
V
V
I
K
P
D
H
E
CV
V
N
-------
S
G
L
G
S
V
R
G
A
R
M
A
E
-----
T
S
F
S
E
-----
A
R
N
T
Q
Q
Q
-
R
L
T
-----
D
--
P
--
L
V
W
R
YG
Q
M
----
Q
P
T
------------
S
W
D
D
A
L
D
L
V
A
R
V
T
A
K
I
V
K
E
K
G
E
D
A
L
I
V
S
A
F
----
D
H
----
G
----
G
A
G
G
G
Y
E
N
T
W
G
T
G
K
L
Y
F
E
A
M
K
V
K
N
I
R
I
H
-----
N
R
P
A
Y
N
S
E
V
H
G
-
T
R
D
M
G
V
G
E
L
N
N
C
Y
E
D
A
E
L
A
D
T
I
V
A
V
G
T
N
A
L
E
-
T
Q
T
N
Y
-
F
L
N
H
W
I
P
N
L
R
G
E
---------
S
-----
L
G
---
K
------------
K
K
E
L
M
----------
P
E
E
P
H
E
A
G
R
I
I
I
V
D
P
R
R
T
V
T
V
N
A
C
E
Q
T
AG
A
--------
D
NV------
L
H
L
A
I
N
S
G
T
D
L
A
L
F
N
A
L
F
T
Y
I
A
---------
D
K
G
W
V
D
R
D
F
I
D
K
STLR
E
G
T
A
R
P
PLYPARGVSEANP
G
H
L
---
S
----------------------------------------------------------------------
S
-------------------------------
F
E
D
A
V
E
G
C
R
M
S
I
E
E
A
-
A
E
I
T
G
L
D
A
A
Q
I
I
K
A
A
E
-
W
------
I
GMPKEG
G
K
R
------
R
-
R
-
V
M
F
G
Y
-
E
K
G
L
I
W
G
N
D
N
Y
R
T
N
G
A
L
V
N
L
A
L
A
T
G
N
I
G
R
P
G
G
------------
G
V
V
R
L
G
G
------------
H
Q
E
G
Y
V
R
P
S
D
A
H
V
-
G
-
R
-
P
A
-
A
---
Y
V
D
----------
Q
L
L
---------
I
G
-----
G
----
Q
-
G
G
V
-----------------------
H
H
I
W
G
C
D
--
H
--
Y
K
--
T
---------------
T
--
L
N
A
H
E
-
F
K
R
V
Y
---
K
K
R
T
D
-
M
V
K
D
A
M
S
--
A
A
P
Y
G
D
------------------------------
R
E
A
M
V
N
A
I
V
--
D
A
I
N
----
Q
G
-
G
--
L
F
A
V
N
V
D
I
I
P
T
K
-
I
G
E
A
C
H
V
I
L
P
A
A
T
S
G
E
M
N
L
T
S
M
N
G
--
E
R
R
---
M
R
L
T
E
R
Y
M
D
P
P
G
Q
S
M
P
D
-
C
L
I
A
A
R
L
A
N
T
M
E
----------------------------------------
R
------
V
------
L
-----------
T
--------
E
M
----------------------------------
G
D
----------------------------------
V
G
-------
Y
A
-------------
A
Q
F
K
G
F
D
WQT
E
E
D
A
F
M
D
--------------
G
--
Y
N
------------
K
------
N
A
---
H
G
----------------
G
E
F
V
T
Y
E
R
L
S
--
A
M
GTNGF----
Q
E
P
ATG
F
T
D
G
-------------
K
I
----
E
----
G
-----
T
Q
R
L
Y
T
-----------
D
G
---
V
F
S
T
D
--------------
D
------------
G
K
A
R
F
M
D
A
P
W
R
GLQAP------
G
-------
K
Q
----
Q
------
Q
K
D
S
H
K
Y
L
-
I
N
N
G
R
A
-
N
V
V
W
Q
S
A
Y
L
D
Q
E
N
D
F
V
M
D
R
F
-
P
Y
P
F
I
E
M
N
P
E
D
M
A
E
A
G
L
K
E
G
D
L
V
E
I
Y
N
D
A
G
---
A
T
--
Q
A
M
A
Y
P
--
T
--
P
T
A
R
R
G
E
T
F
M
L
F
G
F
P
T
G
V
Q
-----------
G
N
V
T
-
S
A
G
T
N
E
L
--
I
I
P
N
Y
K
---
Q
T
-------------
W
-
G
N
I
R
-
K
I
S
D
A
P
R
N
V
A
H
L
S
F
K
S
K
E
Y
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
75.56
20%
-63
- C3 -
2IVF
11
?
A:
[80-976]
----------------
G
S
H
L
N
I
C
WP
Q
G
S
C
K
F
Y
V
Y
V
R
-------------------------------------------
N
G
-------------------------------------------
I
V
-
W
R
E
E
Q
A
A
Q
T
P
--
A
C
NVDYVDY
N
P
L
G
C
Q
K
G
S
A
F
N
N
-----
N
L
Y
G
D
-----
E
R
V
K
Y
P
L
K
R
V
G
-----
K
--
R
GE
G
K
-----
W
----
K
R
V
------------
S
W
D
E
A
A
G
D
I
A
D
S
I
I
D
S
F
E
A
Q
G
S
D
G
F
---
I
L
----
D
A
PHVH
A
----
G
S
I
A
-
W
G
A
G
F
R
M
T
Y
L
M
D
G
V
S
P
D
I
N
-----------
V
D
I
G
D
T
Y
M
G
A
F
H
T
F
G
K
M
H
M
G
Y
S
A
D
N
L
L
D
A
E
L
I
F
M
T
C
S
N
W
S
Y
-
T
Y
P
S
S
-
Y
----------
H
---------
F
-----
L
S
---
E
------------
A
R
Y
K
------------
G
A
-----
E
V
V
V
I
A
P
D
F
N
P
T
---
T
P
A
---
A
--------
D
--------
L
H
V
P
V
R
V
G
S
D
A
A
F
W
L
G
L
S
Q
V
M
I
---------
D
E
K
L
F
D
R
Q
F
V
C
E
------------------------
Q
T
---
D
LP
L
L
V
R
MDTGKFLSAEDVDGGEAK
Q
F
Y
F
F
D
EKAG
S
V
R
K
A
S
RGTLKLDFMPAL
E
G
T
F
S
A
R
L
KNG
K
T
I
Q
V
R
T
V
-------------------------------
F
E
G
L
R
E
H
L
K
D
Y
T
P
E
K
A
S
A
K
C
G
V
P
V
S
L
I
R
E
L
G
R
-
K
------
V
------
A
K
K
--------
R
-
T
C
S
Y
I
-
G
F
S
S
A
K
S
Y
H
G
D
L
M
E
R
S
L
F
L
A
M
A
L
S
G
N
W
G
K
P
G
T
------------
G
A
F
A
W
A
Y
SD
D
N
M
V
Y
L
G
VMS
K
-------
P
T
A
Q
G
-
G
-
M
-
D
E
L
H
---
Q
M
A
----------
E
G
F
N
K
-
R
T
L
E
A
D
P
T
ST
D
E
M
G
----
N
-
I
E
F
M
K
V
V
T
S
A
V
GLVP
P
A
M
W
L
Y
Y
HVGY
D
Q
L
W
N
N
K
--
A
--
W
T
--
D
PALKKS
F
G
A
Y
L
D
E
A
K
E
K
G
W
W
T
N
D
H
I
R
P
A
P
---
D
K
T
P
Q
-
V
Y
M
L
L
S
Q
N
P
M
R
R
K
R
S
------------------------------
G
----
A
K
M
F
P
D
V
L
F
P
----
K
L
-
K
--
M
I
F
A
L
E
T
R
M
-
S
S
-
S
A
M
Y
A
D
I
V
L
P
C
A
W
Y
Y
E
K
H
E
M
T
T
P
C
SG
N
P
F
---
F
T
F
V
D
R
S
V
A
P
P
G
E
C
R
E
E
-
W
D
A
I
A
L
I
L
K
K
V
-----------------------------------------
G
------
E
------
R
A
-------
A
A
R
G
--------
L
T
----------------------------------
E
F
----------------------------------
N
D
HNG
R
K
R
R
Y
D
E
L
Y
K
K
F
T
M
DGHLL
T
N
E
D
C
L
K
---
E
M
V
D
I
N
R
--------------
A
--
V
G
------------
V
------
F
A
---
K
D
----------------
Y
T
Y
E
K
F
K
K
E
G
--
Q
T
---------
R
F
L
---
S
M
G
T
GVSRYAHA
N
E
V
D
V
T
K
----
P
I
Y
P
-
M
-----
R
W
H
F
D
D
-----------
K
K
---
V
F
P
T
H
--------------
T
------------
R
R
A
Q
F
Y
L
D
H
D
W
-----------
Y
L
E
A
GES
L
P
T
H
K
D
T
P
------
M
V
G
G
D
H
P
F
K
I
T
G
G
H
P
-
R
V
S
I
H
S
T
H
L
--
T
N
S
H
L
S
R
L
H
R
G
Q
P
V
V
H
M
N
S
K
D
A
A
E
L
G
I
K
D
G
D
M
A
K
L
F
N
D
F
A
---
D
C
--
E
I
M
V
R
T
--
A
--
P
N
V
Q
P
K
Q
C
I
V
Y
F
W
D
A
H
Q
Y
K
-----------
G
W
K
P
-
Y
D
I
L
L
I
G
--
M
P
K
P
L
H
LAG
G
Y
EQFRYYFMNGSPA
P
V
T
D
R
G
-
V
R
V
S
I
K
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.73
25%
-62
- C3 -
1G8K
5
AIOA_ALCFA
A:
[70-772]
----------------------------
T
N
V
V
T
E
H
D
-------------------------------------------
G
A
-------------------------------------------
R
Y
D
I
M
V
V
P
D
K
A
C
V
--
V
N
-------
S
G
L
S
S
T
R
G
G
K
M
A
S
YMYTP
T
G
D
G
K
-----
E
R
L
S
A
P
R
L
Y
A
A
-----
D
--
E
--
W
V
-----
D
------
T
------------
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
---
F
F
S
C
F
D
H
G
----
G
----
A
G
G
G
-
F
E
N
T
W
G
T
G
K
L
M
F
S
A
I
Q
T
P
M
V
R
I
H
-----
N
R
P
A
Y
N
S
E
C
H
A
-
T
R
E
M
G
I
G
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
-
S
Q
T
N
Y
-
F
----------
L
---------
N
H
W
L
P
N
L
Q
---
G
------------
A
T
T
S
K
K
K
E
R
F
PN
E
N
F
P
Q
A
-----
R
I
I
F
V
D
P
R
E
T
P
S
---
V
A
I
---
A
--------
R
H
V
AGNDRV
L
H
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
---------
E
Q
G
W
I
D
K
P
F
I
E
A
------------------------
H
T
---
K
----------------------------------------------------------------------
G
-------------------------------
F
D
D
A
V
K
T
N
R
-
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
-
W
S
YKPKA
S
------
G
Q
A
------
P
-
R
-
T
M
H
A
Y
-
E
K
G
I
I
W
G
N
D
N
Y
V
I
Q
S
A
L
L
D
L
V
I
A
T
H
N
V
G
R
R
G
T
------------
G
C
V
R
--------------------------
M
G
-
G
-
H
-
Q
E
-
G
---
Y
T
R
----------
P
P
Y
P
G
D
K
K
I
Y
-
I
D
Q
-----
E
L
I
K
G
K
-
G
R
I
-----------------------
M
T
W
W
G
C
N
--
N
--
F
Q
--
T
---------------
S
N
N
A
Q
A
L
R
E
A
I
L
Q
R
---
S
A
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
V
D
------------------------------------
V
I
Y
--
E
A
T
Q
----
N
G
-
G
--
L
F
V
T
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
G
--
E
R
R
---
I
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
-----
C
L
I
A
A
R
I
A
----------------------------------------
N
------
A
------
L
R
-------
D
--
M
Y
Q
------
K
D
----------------------------------
G
K
----------------------------------
A
E
-------
M
A
-------------
A
Q
F
E
G
F
D
---
W
K
T
E
E
D
A
--------------
F
--
N
D
GFRRAGQPGA
P
A
I
------
D
S
---
Q
G
GSTGHL----------
V
T
Y
D
R
L
R
K
S
G
--
N
N
GV-------
Q
L
P
---
V
V
S
W
-------------
D
E
----
S
K
G
L
V
G
-----
T
E
M
L
Y
T
-----------
E
G
---
K
F
D
T
D
--------------
D
------------
G
K
A
H
F
K
P
A
P
W
N
GLP
A
-------
T
-------
V
Q
----
Q
------
Q
K
D
-
K
Y
R
F
W
L
N
N
G
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N
-
N
E
V
W
Q
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A
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L
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Y
-
P
M
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D
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K
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G
G
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F
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F
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M
--
V
Y
P
V
A
-------
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K
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M
L
F
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Y
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N
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Q
-----------
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D
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T
-
T
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W
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--
I
I
P
Y
Y
K
---
G
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-------------
W
-
G
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K
V
G
S
M
S
E
F
K
R
T
V
S
F
K
S
R
R
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Fugue
73.63
23%
-58
- C3 -
2VPZ
4
?
A:
[30-763]
A
P
W
Y
A
Q
E
V
-----
K
S
V
Y
Q
I
C
E
G
C
--
F
W
R
C
G
I
V
A
H
A
V
-------------------------------------------
G
N
-------------------------------------------
R
V
-
Y
K
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P
--
K
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-------
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G
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Q
-----
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T
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-----
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K
R
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L
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E
-----
G
--
S
--
Q
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-----
G
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G
K
Y
R
V
A
------------
T
W
E
E
A
L
D
H
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A
K
K
M
L
E
I
R
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K
Y
G
P
E
A
I
---
A
F
----
F
G
----
H
----
G
T
----
G
D
Y
W
F
V
D
F
L
P
A
A
W
G
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P
N
A
A
K
P
S
-----
V
S
L
C
T
A
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R
E
V
A
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Q
W
V
F
G
R
P
I
G
G
H
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N
A
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Y
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V
L
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G
H
H
I
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D
T
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N
T
Q
-
L
----------
Q
---------
D
-----
F
A
---
L
------------
A
L
K
------------
N
G
A
-----
K
V
V
V
V
D
P
R
F
S
T
A
---
A
A
K
---
A
--------
H
--------
R
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L
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P
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T
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T
A
L
L
L
A
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L
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---------
Y
E
D
L
Y
D
K
E
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V
A
K
------------------------
Y
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---
V
----------------------------------------------------------------------
G
-------------------------------
F
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L
K
A
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K
D
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M
------
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------
K
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Y
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D
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A
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L
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G
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G
G
FY
I
A
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S
P
Y
L
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K
Y
P
L
P
P
L
P
L
------------
E
-------
P
A
A
G
G
-
C
-
S
-
G
P
-
S
---
G
G
D
----------
H
E
P
E
G
F
K
P
R
A
-
D
K
G
-----
K
----
F
-
F
-------------------------
A
R
S
T
A
I
Q
--
E
--
L
I
-------------------------
E
P
M
I
T
G
E
---
P
Y
P
I
K
-
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
------------------------------
V
----
P
R
T
K
--
E
A
L
K
----
N
L
-
D
--
L
Y
V
A
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D
V
L
P
-
Q
E
-
H
V
M
W
A
D
V
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L
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A
T
Y
L
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R
Y
D
D
F
V
L
V
--
A
H
K
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P
F
I
Q
L
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T
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A
H
E
P
L
F
D
T
K
P
G
-
W
W
I
A
R
E
L
G
L
R
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------
L
E
-------
Q
Y
-------------
F
P
W
K
T
I
E
---
E
Y
L
E
T
R
L
--------------
Q
--
S
L
-------------------------
G
----------------
L
D
L
E
T
M
K
G
M
G
--
T
L
V
Q
R
G
K
P
W
L
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D
W
E
---
K
E
G
R
-------------
L
P
----
F
----
G
-----
T
A
S
G
K
I
-----------
E
L
---
Y
C
Q
R
F
--------------
K
------------
E
A
G
H
Q
P
L
P
V
F
T
-----------
P
-------
P
E
----
E
------
P
P
E
G
F
Y
R
L
L
Y
G
-----
R
S
P
V
H
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F
A
R
T
Q
N
N
W
V
L
M
E
M
D
-
P
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N
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V
W
I
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K
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K
R
L
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L
K
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G
D
Y
V
M
L
V
N
Q
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---
V
K
--
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G
P
V
R
V
K
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--
A
R
I
R
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D
C
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Y
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V
H
G
F
G
H
K
A
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LMRLAHG----
R
G
A
S
-
D
N
Y
L
Q
T
R
Y
-
K
L
D
P
I
S
---
G
G
-------------
A
-
G
L
R
V
-
N
F
V
R
L
E
K
A
E
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
S
L
T
G
L
A
K
R
P
F
D
E
R
R
102
HHSearch
73.53
22%
-66
- C3 -
2E7Z
8
AHY_PELAE
A:
[1-727]
--------------
K
K
H
V
V
C
Q
S
C
--
D
I
N
C
V
V
E
A
E
V
K
A------------------------------------------
D
G
-------------------------------------------
K
I
-
Q
T
K
S
I
S
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P
H
P
T-
T
P
-------
P
N
S
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C
M
K
S
V
N
A
D
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-----
I
R
T
H
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-----
D
R
V
L
Y
P
L
K
N
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S----
K
RG
E
--
Q
R
-----
W
----
E
R
I
------------
S
W
D
Q
A
L
D
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A
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K
L
K
K
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A
K
Y
G
P
E
S
L
---
G
V
----
S
Q
----
T
----
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N
Q
-
Q
S
E
Y
G
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L
R
R
F
M
N
-
L
L
G
S
P
N
W
T
S
A
-----
M
Y
M
C
I
G
N
T
A
G
V
H
R
V
T
H
G
S
----
Y
S
F
A
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F
A
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S
N
C
L
L
F
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N
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N
-
H
N
W
V
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----------
N
---------
D
-----
L
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---
A
------------
A
L
K
R
------------
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-----
K
L
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D
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R
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---
A
E
M
---
A
--------
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--------
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---------
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V
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N
------------------------
W
C
---
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----------------------------------------------------------------------
G
-------------------------------
F
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M
------
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------
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------------
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------------
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-------
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-
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I
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A
L
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K
K
L
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E
T
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L
-
T
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T
-
G
M
S
-----
A
----
L
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S
-----------------------
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R
V
Y
G
V
K
--
Y
--
F
H
NM
G
---------------
A
F
M
A
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P
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A
L
F
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A
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A
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P
Y
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A
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A
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A
S
N
A
L
M
G
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A
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------------------------------
Q
----
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--
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L
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----
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A
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A
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Y
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L
A
V
R
M
-----------------------------------------
G
------
L
----------------------------
E
----------------------------------
E
H
----------------------------------
F
P
-------
W
K
-------------
D
R
L
E
L
I
N
---
Y
R
I
------------------------------------------
S
P
---
T
G
----------------
M
E
W
E
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Y
Q
K
Q
Y
--
T
Y
---------
M
S
K
---
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P
D
--------------------------------
Y
F
G
P
E
-----------
G
V
---
G
V
A
T
P
--------------
S
------------
G
K
V
E
L
Y
S
S
V
F
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K
L
GYDP
L
P
Y
Y
H
E
-------
P
L
----
Q
TEISD
P
E
L
A
K
E
Y
P
L
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L
F
A
G
L
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D
S
N
F
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Y
--
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I
L
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D
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-
P
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A
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L
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L
P
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G
E
W
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W
V
E
T
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---
R
L
--
K
L
L
L
K
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--
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--
G
A
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I
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I
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H
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R
W
C
P
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Q
EGGPETGFSGA
M
L
H
N
D
A
M
V
L
S
D
D
DW
N
L
D
P
E
Q
---
G
L
-------------
P
-
N
L
R
G
G
I
L
A
K
A
Y
K
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------