@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2104: (2016-02-04 )
MIYDSLLDLIGGTPVIRLSKLSARLGVSVFAKLESFNPGGSHKARIALWMILDAERKGILVRGKGQTILEPSGGNTGIGLAMAGNILGYRVSLVVPDNYSPDKRQLLELYGAHVVLSDSRKGNNSHGELAIQILLEHPEFVMLNQQRNPANPQAHREATALEILRDFAGQPPPDFFFAGIGTGGHITGVGEVLRNHWPDMAIYGVQPEQCDLLDDRHASHEIQGLSIGIVPEVCNLGIVTGMVGVSKSACLSMIREVLQNDSVSMGLSSAANLVAVLNMASAMPSGARVLTMIYDGVESYMDAFR
Atome Classification :
(47 SA)
-------------------------------------.........10........20....--..--.--.30........40........50........60........70........80........90........100.......110.......120-....---..---...---130......-.140.-......150...-....160.......170.......180.......190....--...200.....------.------.210----....-..-------.-..-220.......230.......240.......250.......260.......270.......280..-......290..-...-..300...-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------M
I
Y
D
S
L
L
D
LIGGT
P
V
I
R
L
S
K
L
S
A
RL--
G
V
--
S
--
V
F
A
K
L
ESFNPGGS
H
K
A
R
I
A
L
W
M
I
L
DAERK
G
I
L
V
RGKG
Q
T
I
L
EPSGGNT
G
I
G
L
AMAGN
I
L
G
Y
R
V
S
L
V
VPDNYSP
D
K
R
Q
L
L
E
L
YG
A
H
V
V
L
SDSR---KGNN---SH---G
E
L
---
A
I
Q
I
L
LEHP-
E
F
V
M
L
-NQQRNPAN
P
Q
A
H
-
R
E
A
T
A
L
E
I
L
R
D
FAGQPPPD
F
F
F
A
GIGTGGH
I
T
G
V
G
E
V
L
R
NH--WPD
M
A
I
YGVQP------E------QC------DLLD-DR-------H-AS-HEIQ
G
L
S
I
G
I
V
P
E
V
CN
L
G
I
V
T
G
MVGV
S
K
S
A
C
L
S
M
I
R
E
V
L
QNDSVSM
G
L
S
S
A
A
N
L
V
A
V
L
N
M
A
S
-AM-PSG
A
R
V
L
T
M
I
Y
-
D
G
V
-
E
S
Y
M
D
AFR-----------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
93.99
38%
-102
- C3 -
3X43
1
?
C:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
92.68
38%
-99
- C3 -
3X43
1
?
G:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
92.61
38%
-99
- C3 -
3X43
1
?
B:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
92.58
38%
-98
- C3 -
3X43
1
?
D:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.89
39%
-118
- C3 -
2EGU
-
?
A:
[6-299]
----------------------------------------
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
R
I
V
D
E
D
--
S
A
--
D
--
V
Y
L
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
--
K
P
G
D
T
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
---
Q
G
M
R
---
G
A
---
I
A
K
---
A
E
E
L
V
R
E
H
G
-
Y
F
-
M
P
----------------
T
T
G
K
E
I
V
E
Q
M
G
D
Q
--
L
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
E
A
--
Y
P
N
I
K
I
Y
A
V
E
P
------
A
------
D
--------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
A
I
H
A
A
L
K
V
A
K
-
E
L
-
G
K
G
K
K
V
L
A
I
I
P
-
S
N
G
-
E
R
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
91.78
38%
-99
- C3 -
3X43
1
?
E:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
91.52
38%
-99
- C3 -
3X43
1
?
H:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.04
38%
-95
- C3 -
3X43
1
?
A:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
91.01
38%
-98
- C3 -
3X43
1
?
F:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
90.61
38%
-120
- C3 -
2EGU
-
?
A:
[4-303]
--------------------------------------
T
V
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
R
I
V
D
E
D
--
S
A
--
D
--
V
Y
L
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
P
G
--
D
T
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
---
Q
G
M
R
---
G
A
---
I
A
K
---
A
E
E
L
V
R
E
-
H
-
G
Y
F
M
P
----------------
T
T
G
K
E
I
V
E
Q
M
G
D
--
Q
L
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
E
A
--
Y
P
N
I
K
I
Y
A
V
E
P
------
A
------
D
--------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
A
I
H
A
A
L
K
V
A
K
-
E
L
-
G
K
G
K
K
V
L
A
I
I
P
-
S
N
G
-
E
R
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
90.47
33%
-101
- C3 -
3PC2
2
?
A:
[50-359]
--------------------------------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
--
G
I
--
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
--
K
P
G
Y
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
---
A
A
Y
D
---
S
P
---
E
G
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
--
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
--
V
P
S
C
Q
I
V
G
V
D
P
YGSILA
R
------
P
A
------
E
L
N
K
-
T
D
-------
V
-
Q
F
-
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
-
K
K
G
Q
R
C
V
V
I
L
P
-
D
G
I
-
R
N
Y
M
T
K
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
90.36
33%
-100
- C3 -
4L27
2
CBS_HUMAN
C:
[75-384]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
ARF
D
S
P
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
90.17
33%
-109
- C3 -
1JBQ
2
CBS_HUMAN
E:
[98-407]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
CE
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
-------
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
89.79
33%
-99
- C3 -
4COO
6
CBS_HUMAN
B:
[98-407]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
ARF
D
S
P
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
89.74
33%
-107
- C3 -
1JBQ
2
CBS_HUMAN
A:
[98-407]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
-------
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.61
38%
-89
- C3 -
3X44
1
?
A:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
89.60
34%
-93
- C3 -
3PC3
2
?
A:
[51-359]
---------------------------------------
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
GI
E
C
--
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
--
Y
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
---
A
A
Y
D
---
S
P
EG
L
I
Y
V
---
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
--
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
--
V
P
S
C
Q
I
V
G
V
D
P
------
Y
------
G
S
------
I
L
A
R
P
A
E
LNKTD--
V
-
Q
F
-
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
-
K
K
G
Q
R
C
V
V
I
L
P
-
D
G
I
-
R
N
Y
M
T
K
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
89.56
33%
-98
- C3 -
4COO
9
CBS_HUMAN
A:
[98-407]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
ARF
D
S
P
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
89.45
37%
-94
- C3 -
1VE1
1
?
A:
[2-300]
-----------------------------------------
R
V
E
G
A
I
G
K
T
P
V
V
R
L
A
K
V
V
E
P
D
--
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
---
R
R
M
L
---
A
A
---
R
E
E
---
A
L
R
L
K
E
E
-
L
-
G
A
F
M
P
-
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
--
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
--
I
P
H
V
K
V
I
A
V
E
P
------
A
------
R
S
------
N
V
L
S
G
G
K
-------
M
-
G
Q
-
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
-
G
P
G
K
R
V
A
C
I
S
P
-
D
G
G
-
W
K
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
89.35
33%
-104
- C3 -
4PCU
2
CBS_HUMAN
B:
[76-385]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
ARF
D
S
P
S
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
89.02
33%
-100
- C3 -
4L0D
2
CBS_HUMAN
B:
[76-385]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
ARF
D
S
P
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
88.86
37%
-93
- C3 -
2ECO
2
?
A:
[7-296]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V
E
P
D
--
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
---
R
R
M
L
---
A
A
---
R
E
E
---
A
L
R
L
K
E
E
L
G
-
A
F
-
M
P
-
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
--
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
--
I
P
H
V
K
V
I
A
V
E
P
------
A
------
R
S
------
N
V
L
S
G
G
K
-------
M
-
G
Q
-
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
-
G
P
G
K
R
V
A
C
I
S
P
-
D
G
G
-
W
K
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.77
33%
-105
- C3 -
4PCU
2
CBS_HUMAN
A:
[76-385]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
--ARF
D
S
P
S
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
88.57
37%
-96
- C3 -
2EFY
2
?
A:
[7-296]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V
E
P
D
--
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
---
R
R
M
L
---
A
A
---
R
E
E
---
A
L
R
L
K
E
E
L
G
-
A
F
-
M
P
-
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
--
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
--
I
P
H
V
K
V
I
A
V
E
P
------
A
------
R
S
------
N
V
L
S
G
G
K
-------
M
-
G
Q
-
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
-
G
P
G
K
R
V
A
C
I
S
P
-
D
G
G
-
W
K
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.32
37%
-92
- C3 -
2ECQ
2
?
A:
[7-296]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V
E
P
D
--
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
---
R
R
M
L
---
A
A
---
R
E
E
---
A
L
R
L
K
E
E
L
G
-
A
F
-
M
P
-
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
--
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
--
I
P
H
V
K
V
I
A
V
E
P
------
A
------
R
S
------
N
V
L
S
G
G
K
-------
M
-
G
Q
-
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
-
G
P
G
K
R
V
A
C
I
S
P
-
D
G
G
-
W
K
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
88.29
37%
-90
- C3 -
3X44
1
?
A:
[2-301]
-------------------------------------
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
--
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
G
---
N
L
I
---
A
D
E
L
A
E
K
-
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
R
G
E
-------
W
-
S
P
-
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
88.26
38%
-90
- C3 -
3X44
1
?
B:
[3-301]
--------------------------------------
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
P
E
---
H
T
--
S
--
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
--
K
P
G
D
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
---
L
G
S
K
---
G
----
G
N
L
---
I
A
D
E
L
A
E
K
Y
-
G
W
F
R
A
-
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
A
G
K
-
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
V
A
--
R
P
E
V
R
V
V
A
L
E
P
------
S
------
N
A
------
A
M
L
A
-
R
G
-------
E
-
W
S
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
E
-
H
A
-
P
E
G
T
V
L
L
A
M
L
P
-
D
T
G
-
E
R
Y
L
S
T
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
88.16
33%
-94
- C3 -
3PC3
2
?
A:
[50-359]
--------------------------------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
--
G
I
--
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
--
K
P
G
Y
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
---
A
A
Y
D
---
S
P
---
E
G
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
--
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
--
V
P
S
C
Q
I
V
G
V
D
P
YGSILA
R
------
P
A
------
E
L
N
K
-
T
D
-------
V
-
Q
F
-
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
-
K
K
G
Q
R
C
V
V
I
L
P
-
D
G
I
-
R
N
Y
M
T
K
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.15
33%
-99
- C3 -
4L0D
2
CBS_HUMAN
A:
[76-385]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
G
K
K
F
--
G
L
--
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
--
K
P
G
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
ARF
D
S
P
E
---
S
H
---
V
G
V
---
A
W
R
L
K
N
E
I
P
-
N
S
H
I
L
-
D
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
--
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
--
C
P
G
C
R
I
I
G
V
D
P
------
E
------
G
S
ILAEPE
E
L
N
Q
-
T
E
-------
Q
-
T
T
-
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
Q
-
E
L
-
Q
E
G
Q
R
C
V
V
I
L
P
-
D
S
V
-
R
N
Y
M
T
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
88.05
33%
-92
- C3 -
3PC4
3
?
A:
[50-359]
--------------------------------------
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
--
G
I
--
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
--
K
P
G
Y
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
---
A
A
Y
D
---
S
P
---
E
G
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
--
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
--
V
P
S
C
Q
I
V
G
V
D
P
YGSILA
R
------
P
A
------
E
L
N
K
-
T
D
-------
V
-
Q
F
-
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
-
K
K
G
Q
R
C
V
V
I
L
P
-
D
G
I
-
R
N
Y
M
T
K
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.02
37%
-93
- C3 -
1VE1
1
?
A:
[7-296]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V
E
P
D
--
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
---
R
R
M
L
---
A
A
---
R
E
E
---
A
L
R
L
K
E
E
L
G
-
A
F
-
M
P
-
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
--
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
--
I
P
H
V
K
V
I
A
V
E
P
------
A
------
R
S
------
N
V
L
S
G
G
K
-------
M
-
G
Q
-
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
-
G
P
G
K
R
V
A
C
I
S
P
-
D
G
G
-
W
K
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
87.22
37%
-91
- C3 -
2EFY
2
?
B:
[7-296]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
V
E
P
D
--
M
A
--
E
--
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
---
R
R
M
L
---
A
A
---
R
E
E
---
A
L
R
L
K
E
E
L
G
-
A
F
-
M
P
-
D
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
--
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
--
I
P
H
V
K
V
I
A
V
E
P
------
A
------
R
S
------
N
V
L
S
G
G
K
-------
M
-
G
Q
-
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
L
-
G
P
G
K
R
V
A
C
I
S
P
-
D
G
G
-
W
K
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
122
Fugue
87.07
33%
-91
- C3 -
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
AHRQ
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
A
S
D
--
G
I
E
C
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
--
K
P
G
Y
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
---
A
A
Y
D
SPE
G
L
---
I
Y
V
---
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
-
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
--
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
--
V
P
S
C
Q
I
V
G
V
D
P
------
Y
GSILAR
P
A
------
E
L
N
K
-
T
D
-------
V
-
Q
F
-
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
R
-
K
L
-
K
K
G
Q
R
C
V
V
I
L
P
-
D
G
I
-
R
N
Y
M
T
K
F
V
S
D
N
W
M
E
A
R
NF
K
E
P
V
NEHGHWWWSLAIAELELPAPP
V
I
L
K
SDAT
V
G
E
A
I
A
L
M
K
K
H
RVD
Q
L
P
V
V
D
QDDGSVL
G
V
V
G
Q
E
T
L
I
T
Q
I
VSMNRQQSDPAIKALNKRV
I
R
L
N
ESEI
L
G
K
L
A
R
V
L
E
V
DP
S
V
L
I
L
G
K
N
PAG
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
GKQK
106
HHSearch
86.37
35%
-96
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[5-307]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
A
E
G
C
--
V
G
--
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
-
E
S
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
---
K
G
M
K
---
G
A
---
I
A
K
---
A
E
E
I
L
A
K
T
P
-
N
G
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
--
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
--
N
A
N
V
K
L
Y
G
V
E
P
------
V
------
E
S
------
A
I
L
S
G
G
K
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
E
N
A
G
K
L
F
V
A
I
F
P
-
S
F
G
-
E
R
Y
L
S
T
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
121
Fugue
85.76
32%
-94
- C3 -
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
G
-----
N
G
--
R
--
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
--
K
P
G
V
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
---
K
G
M
K
---
G
A
---
I
Q
K
---
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
-
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
--
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
KG
K
T
D
L
I
T
V
A
V
E
P
------
T
------
D
S
------
P
V
I
A
-
Q
A
L
A
GE
E
I
K
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
E
S
-
F
T
N
K
N
I
V
V
I
L
P
-
S
S
G
-
E
R
Y
L
S
T
A
L
FADLF------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
85.76
35%
-100
- C3 -
4AEC
3
CYSKM_ARATH
A:
[113-403]
--------------------------------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
A
K
G
C
--
V
A
--
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
G
K
S
-
V
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
---
K
G
M
T
---
G
A
---
V
Q
K
---
A
E
E
I
L
K
N
T
P
-
D
A
Y
M
L
-
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
--
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
--
N
P
K
T
Q
V
I
G
V
E
P
------
T
------
E
S
------
D
I
L
S
G
G
K
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
-
R
P
-
E
N
A
G
K
L
I
A
V
V
F
-
P
S
F
-
G
E
R
Y
L
S
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
85.44
35%
-100
- C3 -
4AEC
4
CYSKM_ARATH
B:
[113-403]
--------------------------------------
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
A
K
G
C
--
V
A
--
N
--
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
G
K
S
-
V
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
---
K
G
M
T
---
G
A
---
V
Q
K
---
A
E
E
I
L
K
N
T
P
-
D
A
Y
M
L
-
Q
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
--
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
--
N
P
K
T
Q
V
I
G
V
E
P
------
T
------
E
S
------
D
I
L
S
G
G
K
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
-
R
P
-
E
N
A
G
K
L
I
A
V
V
F
-
P
S
F
-
G
E
R
Y
L
S
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
84.69
34%
-101
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[5-295]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
A
E
G
C
--
V
G
--
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
E
-
S
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
---
K
G
M
K
---
G
A
---
I
A
K
---
A
E
E
I
L
A
K
T
P
-
N
G
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
--
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
--
N
A
N
V
K
L
Y
G
V
E
P
------
V
------
E
S
------
A
I
L
S
G
G
K
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
-
E
N
A
G
K
L
F
V
A
I
F
-
P
S
F
-
G
E
R
Y
L
S
T
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
84.63
34%
-101
- C3 -
2ISQ
3
CYSK1_ARATH
A:
[3-293]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
A
E
G
C
--
V
G
--
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
E
-
S
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
---
K
G
M
K
---
G
A
---
I
A
K
---
A
E
E
I
L
A
K
T
P
-
N
G
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
--
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
--
N
A
N
V
K
L
Y
G
V
E
P
------
V
------
E
S
------
A
I
L
S
G
G
K
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
-
E
N
A
G
K
L
F
V
A
I
F
-
P
S
F
-
G
E
R
Y
L
S
T
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
83.37
34%
-100
- C3 -
1Z7Y
1
CYSK1_ARATH
A:
[5-295]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
A
E
G
C
--
V
G
--
R
--
V
A
A
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
G
E
-
S
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
---
K
G
M
K
---
G
A
---
I
A
K
---
A
E
E
I
L
A
K
T
P
-
N
G
Y
M
L
-
Q
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
--
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
--
N
A
N
V
K
L
Y
G
V
E
P
------
V
------
E
S
------
A
I
L
S
G
G
K
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
-
R
P
-
E
N
A
G
K
L
F
V
A
I
F
-
P
S
F
-
G
E
R
Y
L
S
T
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
82.96
35%
-100
- C3 -
2Q3B
5
CYSK_MYCTU
A:
[6-303]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
D
G
A
--
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
--
T
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
---
D
G
M
S
---
G
A
---
I
A
K
---
A
E
E
L
A
K
T
-
D
-
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
--
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
--
K
P
S
A
R
F
V
A
V
E
P
------
A
------
A
S
------
P
V
L
S
G
G
Q
-------
K
-
G
P
-
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
-
R
P
E
N
A
G
K
L
I
V
V
V
L
P
-
D
F
G
-
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
82.37
34%
-92
- C3 -
2Q3D
2
CYSK_MYCTU
A:
[6-303]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
D
G
A
--
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
--
K
P
D
T
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
---
D
G
M
S
---
G
A
---
I
A
K
---
A
E
E
L
A
K
T
D
Q
-
R
Y
F
V
P
-
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
--
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
--
K
P
S
A
R
F
V
A
V
E
P
------
A
------
A
S
------
P
V
L
S
G
G
Q
-------
K
-
G
P
-
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
-
R
P
-
E
N
A
G
K
L
I
V
V
V
L
P
D
F
G
-
E
R
Y
L
S
T
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
81.56
34%
-90
* C3 *
4LMA
3
?
A:
[10-313]
--------------------------------------
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
Q
A
E
--
G
C
L
G
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
-
L
I
N
P
E
T
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
---
Q
G
M
K
---
G
A
---
I
L
R
---
A
Q
Q
I
V
D
S
I
P
-
G
A
Y
M
L
-
Q
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
--
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
--
K
P
S
F
Q
V
V
A
V
E
P
------
F
------
N
S
------
P
V
I
S
-
G
G
-------
N
P
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
-
R
P
-
E
N
E
G
K
L
I
V
V
I
Q
-
P
S
F
G
E
R
Y
L
S
T
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
81.35
34%
-99
- C3 -
3ZEI
4
CYSK_MYCTU
A:
[3-300]
--------------------------------------
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
D
G
A
--
V
A
--
D
--
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
--
K
P
D
T
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
---
D
G
M
S
---
G
A
---
I
A
K
---
A
E
E
L
A
K
T
D
Q
-
R
Y
F
V
P
-
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
--
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
--
K
P
S
A
R
F
V
A
V
E
P
------
A
------
A
S
------
P
V
L
S
G
G
Q
-------
K
-
G
P
-
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
-
R
P
-
E
N
A
G
K
L
I
V
V
V
L
P
D
F
G
-
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
81.17
34%
-90
- C3 -
4LMA
2
?
B:
[10-313]
--------------------------------------
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
Q
A
E
--
G
C
LG
R
--
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
-
L
I
N
P
E
T
T
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
---
Q
G
M
K
---
G
A
---
I
L
R
---
A
Q
Q
I
V
D
S
I
P
-
G
A
Y
M
L
-
Q
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
--
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
--
K
P
S
F
Q
V
V
A
V
E
P
------
F
------
N
S
------
P
V
I
S
-
G
G
-------
N
P
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
Q
-
R
P
-
E
N
E
G
K
L
I
V
V
I
Q
-
P
S
F
G
E
R
Y
L
S
T
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
77.04
32%
-89
- C3 -
4LMB
3
?
A:
[9-301]
-------------------------------------
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
V
A
E
--
G
V
--
K
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
-
L
I
H
P
D
K
T
I
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
---
Q
G
M
E
---
G
A
---
I
T
R
---
A
E
E
I
V
E
N
T
P
-
N
A
Y
S
L
-
Q
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
--
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
R
--
R
P
Q
F
Q
A
I
A
V
E
P
------
S
------
N
S
------
P
V
L
S
G
G
Q
-------
P
-
G
P
-
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
-
R
P
-
E
N
E
D
K
L
I
V
M
I
Q
-
P
S
F
-
G
E
R
Y
L
S
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
76.34
31%
-95
- C3 -
2BHS
1
CYSM_ECOLI
A:
[3-287]
-----------------------------------------
T
L
E
Q
T
I
G
N
T
P
L
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---------------
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