@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2567: (2016-02-09 )
MATPPYPEDEHSRQAYVDQLGLLEEGADEVFEEILAAATSYFQTPIALISILDHQRQWFRASIGLDIRQTPRRDSFCAYAILGKGVFEVADATLDPRFRDNPYVQGEPRIRFYAGAPLATAEGLNLGSLCVIDREPRGPLAERDVAMLEHFARLVMARIHTLRSTNYIDEPTGLYNRLRLQEDVSLRLQRDGALTVIAADLLPLALLNTIIRTLGYPFSNDLMLEARDRIRAELPDFTLYKISPTRFGLLLPRQQQEETESVCLRLLRAFESPVVCRGIPIKANVGLGVLPLADDTLDGDQDWLRLVVSAADDARDRGVGWARYNPPLDQAQQRAFTLLTSLSQAIGTEEGFHLVYQPKIDLPTGRCTGVEALLRWRHPQLGFVSPAEFVPLAEKTALMRPLSDWVLRHAMAQLAQWNARNIPLRLAINVSASDMEDSSFLEEAVRLAKTYDIDLSALELEFTESVLIRDASAVGSVLLRARELGMGIAVDDFGTGYSNWTYLRDLPITAIKLDQSFTRDLAGSPKAQSVTQAVIGLASQLGYRVVAEGIETHDTFHLLQAWGCHEGQGYLIAQPMLPEQLEDWLRR
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......---190.......200.......210.......220.......230...-----....240.......250......---------.260......-.270.......280.......290.......300.......310.......320-.........330...-----....340.......350........360....-...370.......380.......390.......400.....-------..410.......420--..---.-.....430.......---440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580......-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATPPYPEDE
H
S
R
Q
A
Y
V
D
Q
L
G
L
L
EE
G
A
D
E
V
F
E
E
I
L
A
A
A
T
S
Y
FQ
T
P
I
A
L
I
S
I
L
DH
Q
R
Q
W
F
R
A
SIGLDIRQTPRRDSF
C
A
Y
A
I
L
G
K
G
V
F
E
V
ADATLDPRFRDNPYVQGEP
R
I
R
F
YAGAPLATAEGLNL
G
S
L
C
V
I
DREPRGPL
A
E
R
D
V
A
M
L
E
H
F
A
R
L
V
M
A
R
I
H
T
LRSTNYIDEP
T
G
L
Y
N
R
L
R
LQED
V
S
L
R
L
Q---RDG
A
L
T
V
I
A
A
D
L
L
P
L
A
L
L
N
T
I
I
R
TLGYPFSN
D
L
M
L
E
A
R
D
R
I
R
AELP-----D
F
T
L
Y
K
ISP
T
R
F
G
L
LLPR
Q
Q
Q
E
E
---------
T
E
S
V
C
L
R
L
L
R
-
A
FESP
V
V
CRGIPIKANVGLGVLPLADDTLDG
D
Q
D
W
L
R
L
V
V
SAADDARDRGVG---WARYNP
P
L
D
Q
A
Q
Q
R
A
-----
F
T
L
L
T
S
L
S
Q
A
IGTEE
G
-
F
H
L
V
Y
QPKIDLPTGR-
C
T
G
V
E
A
L
L
R
WRHPQLGFV
S
P
A
E
FVP
L
A
E
K
T
A
L
MR
P
L
S
D
W
V
L
-------
R
H
A
M
A
Q
L
A
QWNARN---I
P
---
L
-
R
L
A
I
NVSASDME
D
S
S
---
F
L
E
E
A
V
R
L
A
K
TYDID
L
S
A
L
E
L
E
FT
E
S
V
L
IR
D
A
S
A
V
G
S
V
L
L
R
A
R
E
LGM
G
I
A
V
DDFGTGYSN
W
T
Y
L
RDLP
I
T
A
I
KL
D
Q
S
F
T
R
D
LAGSP
K
A
Q
S
V
T
Q
A
V
I
G
L
A
S
Q
L
G
Y
R
V
V
A
EGIET
H
D
T
F
H
L
L
Q
A
WGCHEGQ
G
Y
L
I
AQPM
L
P
E
Q
-
L
E
D
W
LRR-------
2
PsiBlast_PDB
89.26
32%
-105
- C4 -
4RNH
3
?
A:
[23-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
--
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
Q
G
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
-
P
F
--
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
-----
D
G
A
E
--
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
---
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
--
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
-------
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
---
V
R
---
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
---
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-
F
-------------
3
PsiBlast_PDB
89.22
32%
-104
- C4 -
4RNF
-
?
A:
[23-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
--
F
L
D
L
D
-----
N
D
S
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
Q
G
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
-
P
F
--
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
-----
D
G
A
E
--
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
---
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
--
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
-------
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
---
V
R
---
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
---
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
N
N
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-
F
-------------
34
HHSearch
77.48
22%
-86
* C4 *
3PJX
9
?
A:
[12-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
T
E
S
Y
Q
D
N
L
T
G
L
A
N
R
R
Y
F
E
M
Q
L
N
A
R
V
S
---
N
P
E
Q
A
S
S
G
Y
L
L
L
L
R
V
K
D
L
A
G
L
N
Q
R
L
G
G
Q
R
T
D
E
L
L
K
A
V
G
E
Q
L
S
R
E
C
A
KYPET
Q
N
L
V
T
R
I
R
G
G
E
F
A
V
L
A
P
G
M
T
R
E
E
---------
A
L
Q
L
A
Q
S
L
D
S
-
A
L
S
S
L
Y
A
T
G
A
T
D
V
A
A
V
A
S
I
G
L
A
P
F
A
H
-
G
D
S
P
Q
-
A
V
L
S
L
G
D
Q
A
L
A
Q
A
E
G
Q
G
E
Q
N--
W
A
C
L
D
------
G
D
D
H
-----
H
A
W
H
R
L
L
D
Q
A
L
N
-
Q
R
R
-
F
E
L
F
F
Q
P
V
V
A
A
Q
D
T
Q
L
V
L
H
Y
K
V
L
S
R
L
L
D
E
Q
G
Q
T
I
P
A
G
R
F
L
P
W
L
E
R
F
G
W
T
A
R
L
D
R
L
M
L
-------
E
R
V
L
E
Q
M
A
G
H
--------
E
---
E
-
S
L
A
L
N
L
S
S
A
T
L
A
D
P
Q
---
A
L
N
K
V
F
E
I
L
R
A
H
S
N
L
G
A
R
L
T
L
E
I
G
E
E
Q
L
P
E
Q
-
A
V
L
E
Q
L
T
R
R
L
R
E
L
G
F
S
L
S
L
Q
R
F
G
G
R
F
S
M
I
G
N
L
A
R
L
G
L
A
Y
L
K
I
D
G
S
Y
I
R
A
I
D
Q
E
S
D
K
R
L
F
I
E
A
I
Q
R
A
A
H
S
I
D
L
P
L
I
A
E
R
V
E
T
E
G
E
L
S
V
I
R
E
M
G
L
Y
G
V
Q
G
Q
L
F
G
E
P
K
P
W
-----------------
6
PsiBlast_PDB
75.62
38%
-102
- C4 -
2R6O
4
?
A:
[24-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
--
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
-------
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
---
R
A
ADD
L
-
T
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
---
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
-
F
A
S
L
L
D
R
-------
7
PsiBlast_PDB
75.35
38%
-104
- C4 -
3N3T
4
?
A:
[23-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
------
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
--
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
-------
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
---
R
A
ADD
L
-
T
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
---
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
-
F
A
S
L
L
D
R
-------
36
HHSearch
74.60
36%
-102
- C4 -
2R6O
4
?
A:
[24-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
L
T
L
D
T
R
L
R
Q
A
L
E
-
R
N
E
-
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
-------
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
RAA
D
D
---
L
-
T
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
---
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
-
F
A
S
L
L
D
R
-------
10
PsiBlast_PDB
73.91
33%
-107
- C4 -
4HJF
3
?
A:
[74-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
--
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
-------
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
---
P
A
M
G
N
L
-
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
---
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
-
A
E
V
Y
L
N
--------
8
PsiBlast_PDB
73.67
32%
-112
- C4 -
4HU3
-
A:
[24-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
M
N
E
M
V
K
E
R
-----
L
V
L
G
A
A
L
K
E
A
I
S
N
N
Q
--
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
E
-
L
Y
G
I
E
A
L
A
R
W
H
D
P
L
H
G
H
V
P
P
S
R
F
I
P
L
A
E
E
I
G
E
I
E
N
I
G
R
W
V
I
-------
A
E
A
C
R
Q
L
A
E
W
R
S
Q
N
---
I
H
---
I
P
A
L
S
V
N
L
S
A
L
H
F
R
S
N
Q
---
L
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
Q
L
T
V
E
I
T
E
S
M
M
M
E
H
D
T
E
I
F
K
R
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
T
G
F
S
G
L
S
R
L
V
S
L
P
V
T
E
I
K
I
D
K
S
F
V
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
E
G
V
E
T
K
E
Q
F
E
M
L
R
K
I
H
C
R
V
I
Q
G
Y
F
F
S
R
P
L
P
A
E
E
-
I
P
G
W
M
---------
39
HHSearch
73.03
35%
-104
- C4 -
3S83
2
?
A:
[3-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
D
L
R
G
A
I
G
-
R
G
E
-
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
-------
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
PAM
G
N
---
L
-
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
---
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
-
A
E
V
Y
L
N
--------
12
PsiBlast_PDB
72.77
33%
-106
- C4 -
3S83
2
?
A:
[1-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
--
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
-------
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
---
P
A
MGN
L
-
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
---
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
-
A
E
V
Y
L
---------
5
PsiBlast_PDB
72.77
38%
-107
- C4 -
4RNJ
-
?
A:
[47-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
-------
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
---
V
R
---
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
---
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-
F
-------------
11
PsiBlast_PDB
72.19
33%
-101
- C4 -
3U2E
3
?
A:
[4-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
--
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
-------
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
---
P
A
MGN
L
-
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
---
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
-
A
E
V
Y
L
---------
4
PsiBlast_PDB
72.00
38%
-108
- C4 -
4RNI
-
?
A:
[47-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
-------
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
---
V
R
---
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
---
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-
F
-------------
40
HHSearch
71.86
31%
-102
- C4 -
3SY8
1
?
A:
[142-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
A
D
V
V
R
G
L
D
-
N
G
E
-
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
W
Q
L
F
-------
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
---
Q
P
---
I
-
N
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
---
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
E
Q
H
-
F
L
D
Y
C
---------
55
Fugue
68.34
23%
-83
- C4 -
3SY8
2
?
D:
[3-398]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
N
V
L
V
L
--
Q
R
-----
L
V
A
V
T
A
L
K
K
V
V
P
G
S
I
L
E
A
A
D
G
K
E
---------
A
V
A
I
L
E
D
I
A
I
C
D
L
Q
M
S
G
M
D
G
L
A
F
L
R
H
A
S
L
S
G
K
V
H
S
V
I
L
S
S
E
V
D
P
I
L
R
Q
A
T
I
S
M
I
E
C
L
G
L
N
F
L
G
DE
R
I
T
A
L
L
T
R
Y
N
A
R
E
V
A
E
-----
L
P
S
V
A
D
V
V
R
G
L
D
N
G
E
--
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
W
Q
L
F
-------
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
---
Q
P
---
I
-
N
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
---
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
E
Q
H
-
F
L
D
Y
C
S
G
S
L
E
H
H
H
H
23
PsiBlast_CBE
68.07
35%
-88
- C4 -
3SY8
1
?
B:
[150-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
-
W
Q
L
F
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
Q
---------
P
---
I
-
N
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
---
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
-
P
E
Q
---------------
21
PsiBlast_CBE
66.97
35%
-91
- C4 -
3SY8
2
?
D:
[150-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
-
W
Q
L
F
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
Q
---------
P
---
I
-
N
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
---
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
-
P
E
Q
---------------
22
PsiBlast_CBE
66.06
35%
-87
- C4 -
3SY8
1
?
C:
[150-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
-
W
Q
L
F
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
Q
---------
P
---
I
-
N
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
---
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
-
P
E
Q
---------------
13
PsiBlast_PDB
66.02
35%
-88
- C4 -
3SY8
1
?
A:
[150-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
-
W
Q
L
F
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
Q
---------
P
---
I
-
N
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
---
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
-
P
E
Q
---------------
9
PsiBlast_PDB
64.21
32%
-95
- C4 -
4HU4
-
DOSP_ECOLI
A:
[34-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
L
V
L
G
A
A
L
K
E
A
I
S
N
N
Q
--
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
E
-
L
Y
G
I
E
A
L
A
R
W
H
D
P
L
H
G
H
V
P
P
S
R
F
I
P
L
A
E
E
I
G
E
I
E
N
I
G
R
W
V
I
-------
A
E
A
C
R
Q
L
A
E
W
R
S
Q
N
---
I
H
---
I
P
A
L
S
V
N
L
S
A
L
H
F
R
S
N
Q
---
L
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
Q
L
T
V
E
I
T
E
S
M
M
M
E
H
D
T
E
I
F
K
R
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
-----------
L
P
V
T
E
I
K
I
D
K
S
F
V
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
E
G
V
E
T
K
E
Q
F
E
M
L
R
K
I
H
C
R
V
I
Q
G
Y
F
F
S
R
P
L
P
A
E
E
-
I
P
G
W
M
---------
17
PsiBlast_PDB
63.99
30%
-93
- C4 -
4Q6J
7
?
A:
[18-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
-
Y
L
L
Y
Y
Q
P
K
V
D
A
K
T
N
K
-
I
I
G
F
E
G
L
V
R
L
K
T
A
T
-
T
I
L
A
P
I
D
F
F
D
D
I
V
L
L
N
A
T
R
E
M
Q
D
F
V
A
-------
E
T
A
I
K
Q
I
N
Q
L
G
G
R
---------
F
-
S
I
S
I
N
I
P
A
H
Y
V
A
S
S
T
Y
M
T
F
L
H
D
Y
V
K
E
H
L
K
Y
P
---
E
C
L
E
I
E
I
I
E
R
---
T
E
L
A
I
A
D
K
N
L
R
K
I
K
D
L
G
V
K
V
S
M
D
D
F
G
K
G
Y
S
S
L
A
Y
L
R
S
L
P
I
D
I
V
K
T
D
M
S
F
I
A
L
L
K
T
D
R
K
Q
Q
I
I
I
R
A
I
V
N
L
C
H
D
L
G
G
K
V
V
T
E
G
V
E
D
M
E
Q
V
E
K
L
R
E
M
K
V
D
Y
F
Q
G
Y
Y
F
S
R
P
L
P
M
E
E
-
I
K
------------
15
PsiBlast_PDB
60.00
30%
-73
- C4 -
4LJ3
5
YAHA_ECOLI
A:
[44-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
V
F
C
A
Q
T
G
V
-
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
-------
K
Q
T
-
A
D
I
L
M
P
V
K
H
L
---
L
P
DN-
F
-
H
I
G
I
N
V
S
A
G
C
F
L
A
A
G
---
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
I
S
E
W
V
M
K
-------
29
PsiBlast_CBE
47.81
36%
-77
- C4 -
3GFX
2
?
B:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
27
PsiBlast_CBE
47.75
36%
-73
- C4 -
3GG0
3
?
A:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
28
PsiBlast_CBE
47.57
36%
-80
- C4 -
3GFZ
3
?
B:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
20
PsiBlast_PDB
46.90
36%
-69
- C4 -
3GFZ
3
?
A:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
26
PsiBlast_CBE
46.23
36%
-72
- C4 -
3GG0
3
?
B:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
24
PsiBlast_CBE
46.06
36%
-78
- C4 -
3GG1
3
?
B:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
19
PsiBlast_PDB
45.30
36%
-69
- C4 -
3GFX
2
?
A:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------
25
PsiBlast_CBE
45.19
36%
-71
- C4 -
3GG1
3
?
A:
[279-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
L
------------------