@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2926: (2016-02-12 )
MYSLQVEDIHKRYGSHEVLRGVSLRAGKGDVISIIGSSGSGKSTFLRCVNFLEKPCAGHIRVGDEELRTRPGALGELRAADPRQLQRIRSRLAMVFQHFNLWSHLTVLENVVECPVNVLRMNRDDAVARARHYLAKVGLAEKVERQYPCELSGGQQQRVAIARALAMEPQVMLFDEPTSALDPELVGEVLKVMQQLAEEGRTMVLVTHEMAFARQVSSHVIFLHQGVIEEEGTPDQVFGAPRSERLRQFLAGNLK
Atome Classification :
(37 SA)
.........10--.....-..----..20........30........40........50....-....60..-----------......70........80........-90-........100.......110.......120--.........130.......140.--......150.......160.....-..170.......180...----....190.-......-200.......210.......220...-....230.......240-.......250...---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MY
S
L
Q
V
E
D
I
H
---
K
RYG
S
-
H
E
----
V
L
R
G
V
SLRAGKG
D
V
I
S
I
IGSSGS
G
K
S
T
F
L
R
C
V
N
F
L
E
KP-CAG
H
I
R
VG-----------
D
E
E
L
RTRPGALGELRAA
D
P
R
Q
L
Q
R
I
R
-
S
R
-
L
A
M
V
F
Q
H
F
N
L
W
S
H
L
T
V
L
E
N
V
V
EC
P
V
N
V
L
R----MNR
D
D
A
V
A
R
A
R
H
Y
L
A
KV
G
L
A
E
K
V
--
E
R
QYPCELSGG
Q
Q
Q
R
V
A
I
A
R
A
LAM-EP
Q
V
M
L
F
DEPTSAL
D
P
E
L
----
V
G
E
V
L
K
V
M
-
Q
Q
L
A
EE-G
R
T
M
V
L
V
T
H
E
M
A
F
A
R
Q
V
SS
H
V
I
F
L
HQ-GVIEEEGT
P
D
QVFGA
P
R
-
S
E
R
L
R
Q
F
L
AGNLK---
59
Fugue
97.60
72%
-133
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
-
N
K
L
H
V
I
D
L
H
---
K
R
Y
G
G
H
E
V
----
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S-
E
G
A
I
I
V
N
GQNI
N
L
V
R
D
KD-----------
G
Q
L
K
V
A
D
K
N
Q
L
R
L
L
R
-
T
-
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
-G---
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
QG--
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
----
V
G
E
V
L
R
I
M
-
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
KLE
77
HHSearch
96.57
69%
-119
- C1 -
1B0U
4
HISP_SALTY
A:
[5-257]
-
N
K
L
H
V
I
D
L
H
---
K
R
Y
G
G
-
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-
S
E
G
A
I
I
V
N
-----------
G
Q
N
I
N
L
V
R
D
K
D
G
Q
L
K
V
A
D
K
N
Q
L
R
L
L
R
-
T
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
----
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
--
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
----
V
G
E
V
L
R
I
M
-
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
-
S
P
R
L
Q
Q
F
L
K
G
S
L
----
1
PsiBlast_PDB
96.39
69%
-118
- C1 -
1B0U
4
HISP_SALTY
A:
[6-258]
--
K
L
H
V
I
D
L
H
---
K
R
Y
G
G
-
H
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-
S
E
G
A
I
I
V
N
-----------
G
Q
N
I
N
L
V
R
D
K
D
G
Q
L
K
V
A
D
K
N
Q
L
R
L
L
R
-
T
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
----
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
--
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
----
V
G
E
V
L
R
I
M
-
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
-
S
P
R
L
Q
Q
F
L
K
G
S
L
K
---
6
PsiBlast_PDB
85.04
54%
-123
- C1 -
4YMW
-
?
J:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
22
PsiBlast_CBE
84.85
54%
-121
- C1 -
4YMU
2
?
A:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
78
HHSearch
83.36
53%
-117
* C1 *
2OLJ
4
?
A:
[22-261]
L
Q
M
I
D
V
H
Q
L
K
---
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
---
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
------
21
PsiBlast_CBE
83.33
54%
-119
- C1 -
4YMV
1
?
A:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
5
PsiBlast_PDB
83.09
54%
-119
- C1 -
4YMV
1
?
J:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
14
PsiBlast_PDB
82.95
50%
-114
- C1 -
4U02
1
?
A:
[5-238]
---
I
R
I
R
N
L
H
---
K
W
F
G
P
-
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
E
G
E
V
V
V
D
-----------
G
------------
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
----
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
3
PsiBlast_PDB
82.89
54%
-118
- C1 -
4YMT
-
?
J:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
2
PsiBlast_PDB
82.89
54%
-119
- C1 -
4YMS
-
?
J:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
34
PsiBlast_CBE
82.49
50%
-119
- C1 -
4U02
1
?
C:
[5-238]
---
I
R
I
R
N
L
H
---
K
W
F
G
P
-
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
E
G
E
V
V
V
D
-----------
G
------------
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
----
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
4
PsiBlast_PDB
82.42
54%
-118
- C1 -
4YMU
2
?
J:
[4-237]
-----
V
N
D
V
Y
---
K
N
F
G
S
-
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
K
G
E
V
F
I
-------------
D
G
V
K
I
N
N
G
K
V
---------
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
----
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
---
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
33
PsiBlast_CBE
82.07
50%
-112
- C1 -
4U02
1
?
D:
[5-238]
---
I
R
I
R
N
L
H
---
K
W
F
G
P
-
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
E
G
E
V
V
V
D
-----------
G
------------
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
----
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
13
PsiBlast_PDB
81.81
50%
-117
- C1 -
4U00
3
?
A:
[5-238]
---
I
R
I
R
N
L
H
---
K
W
F
G
P
-
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
E
G
E
V
V
V
D
-----------
G
------------
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
----
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
35
PsiBlast_CBE
81.69
50%
-114
- C1 -
4U02
1
?
B:
[5-238]
---
I
R
I
R
N
L
H
---
K
W
F
G
P
-
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
E
G
E
V
V
V
D
-----------
G
------------
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
----
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
---
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
25
PsiBlast_CBE
80.25
51%
-111
- C1 -
2OUK
2
?
D:
[23-260]
----
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
28
PsiBlast_CBE
80.15
51%
-113
- C1 -
2OLK
1
?
D:
[22-260]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
8
PsiBlast_PDB
80.00
51%
-110
- C1 -
2OLK
1
?
A:
[22-260]
---
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
9
PsiBlast_PDB
79.96
51%
-112
- C1 -
2OUK
1
?
A:
[22-260]
---
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
7
PsiBlast_PDB
79.70
51%
-115
- C1 -
2OLJ
4
?
A:
[22-260]
---
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
29
PsiBlast_CBE
79.68
51%
-108
- C1 -
2OLK
1
?
C:
[22-260]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
32
PsiBlast_CBE
79.23
51%
-110
- C1 -
3C41
3
?
K:
[1-239]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
23
PsiBlast_CBE
78.74
51%
-114
- C1 -
3C4J
4
?
B:
[22-260]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
10
PsiBlast_PDB
78.74
51%
-109
- C1 -
2Q0H
4
?
A:
[23-260]
----
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
12
PsiBlast_PDB
78.56
51%
-106
- C1 -
3C41
3
?
J:
[1-239]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
30
PsiBlast_CBE
78.21
51%
-112
- C1 -
2OLK
2
?
B:
[22-260]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
11
PsiBlast_PDB
77.65
51%
-106
- C1 -
3C4J
3
?
A:
[22-260]
---
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
24
PsiBlast_CBE
77.48
51%
-113
- C1 -
2Q0H
4
?
B:
[22-260]
---
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
48
PsiBlast_CBE
76.70
35%
-127
- C1 -
1L2T
4
Y796_METJA
B:
[2-232]
---
I
K
L
K
N
V
T
---
K
T
Y
K
M
-
G
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
E
G
E
V
Y
I
-------------
D
N
I
K
T
N
D
--------
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
-
I
F
K
YRGA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
----
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
------------
R
-
E
E
K
L
R
G
F
---------
51
PsiBlast_CBE
76.59
36%
-125
- C1 -
3TIF
7
Y796_METJA
A:
[2-226]
---
V
K
L
K
N
V
T
---
K
T
Y
K
M
-
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
E
G
E
V
Y
I
-------------
D
N
I
K
T
N
D
--------
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
-
I
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
----
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
----------------------------
49
PsiBlast_CBE
75.94
35%
-124
- C1 -
1L2T
4
Y796_METJA
A:
[2-230]
---
I
K
L
K
N
V
T
---
K
T
Y
K
M
-
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
E
G
E
V
Y
I
-------------
D
N
I
K
T
N
D
--------
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
-
I
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
----
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
------------
R
-
E
E
K
L
R
-----------
31
PsiBlast_CBE
75.28
51%
-106
- C1 -
2OLJ
3
?
B:
[22-260]
---
L
Q
M
I
D
V
H
QLK
K
S
F
G
S
-
L
E
----
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
E
G
E
I
I
I
D
-----------
G
I
N
L
K
-----------
A
K
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
----
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
---
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
-------
50
PsiBlast_CBE
74.89
36%
-129
- C1 -
3TIF
7
Y796_METJA
B:
[2-226]
---
V
K
L
K
N
V
T
---
K
T
Y
K
M
-
G
E
EIIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
E
G
E
V
Y
I
-------------
D
N
I
K
T
N
D
--------
L
D
D
D
E
L
T
K
I
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
L
-
I
F
K
YRGA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
--
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
----
G
E
K
I
M
Q
L
L
-
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
----------------------------
47
PsiBlast_CBE
71.10
31%
-117
- C1 -
1VCI
1
?
A:
[10-251]
M
V
E
V
K
L
E
N
L
T
---
K
R
F
G
N
-
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
-
T
E
G
R
I
Y
F
G
-----------
D
R
D
V
T
Y
L
P
----------
P
K
D
------
R
N
-
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
-
F
P
L
--
K
K
----
F
P
K
D
E
I
D
K
R
V
R
-
W
A
A
E
L
L
Q
I
E
E
L
--
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
-
Q
K
L
K
----
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
-
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
-
S
V
F
V
A
T
F
I
G
A
------
52
PsiBlast_CBE
69.12
32%
-105
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[4-230]
--
A
L
H
I
G
H
L
S
---
K
S
F
Q
N
-
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
-
D
S
G
E
I
S
L
S
-----------
G
K
T
I
F
S
K
N
-----------
T
N
L
P
V
R
E
-
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
-
K
----
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
--
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
----
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
------------------
53
PsiBlast_CBE
67.93
32%
-103
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-235]
--
A
L
H
I
G
H
L
S
---
K
S
F
Q
N
-
T
P
----
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
-
D
S
G
E
I
S
L
S
-----------
G
K
T
I
F
S
K
N
-----------
T
N
L
P
V
R
E
-
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
-
K
----
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
--
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
----
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
------------------