@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3254: (2016-02-15 )
MSFVSVEQLDKSYGATSIFRDIDFAAARGEFVTLLGPSGCGKSTLLRCIAGLTEVDSGRILIDGEDVVPLPPQKRGIAMVFQSYALFPNMTVQQNVAFGLRMQKVPAAELKQRVAEAIELVELGEYAARYPHQLSGGQCQRVALARSLVTRPRLLLLDEPLSALDARIRKHLREQIRRIQQELGLTTVFVTHDQEEALTLSDRIVLMNAGRIVQSGDAETLYTAPENAFAAGFIGNYNLLDAEQASRLLGQSCAQQVAIRPESLRLGNEPSEGVPALVRSHSLLGNVIRYRVEAAGVELTVDVLNRSADRLYPAGSQLTLVIDRNSIREVA
Atome Classification :
(46 SA)
-.........10..--.-.--....--20........30........40........50........60...------...----.-----.-----70.....----------------...80.--.......90........-100.---......110.......120..-.-..-..130.......140.......150.......160.......170.......180-........190.......200.......210.......220.......230....--.--..240.-------------....-------------------.------------------------.250--------------.....----------.-------------------..--.260.......270----..-----.-......280.......290.....--..300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MSF
V
S
V
E
Q
L
D
K
SY--G-
A
--
T
S
I
F
--
R
D
IDFAAARG
E
F
V
T
L
LGPSGC
G
K
S
T
L
L
R
C
I
A
G
L
TEVDS
G
R
I
L
IDG------EDV----V-----P-----LPPQKR
G
----------------
I
A
M
V
F
Q
--
S
Y
ALFPN
M
T
V
Q
QN
V
A
F
G
-
L
R
M
Q---KV
P
A
A
E
L
K
Q
R
V
A
E
A
I
E
L
V
E
L
G
-
E
-
Y
A
-
A
RYPHQLSGG
Q
C
Q
R
V
A
L
A
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VTRP
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L
L
LDE
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--ELG
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THDQEEALTLS
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NA
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TAPEN
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AAGFIGN--Y--NLL
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A
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-------------------VA--IR
P
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LRLGNEP------SE-----
G
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N
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VEAAG
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T
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V
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NRSADRLYPAG
S
Q
L
T
L
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I
DR
N
S
I
REVA-
103
HHSearch
89.47
39%
-123
- C1 -
2IT1
-
?
A:
[1-349]
-
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--
106
HHSearch
89.00
41%
-109
- C1 -
2YYZ
3
?
A:
[2-350]
--
P
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124
Fugue
88.49
38%
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- C1 -
1Z47
1
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A:
[11-355]
G
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107
HHSearch
87.60
38%
-120
- C1 -
1Z47
1
?
A:
[13-353]
--
M
T
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102
HHSearch
86.79
40%
-123
- C1 -
1V43
-
?
A:
[10-364]
-
M
V
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G
-------------------
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--
5
PsiBlast_PDB
84.11
40%
-120
- C1 -
2YYZ
3
?
A:
[2-314]
--
P
S
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V
N
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T
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G
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I
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F
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------
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V
----
N
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-----
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P
P
K
Y
R
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----------------
V
G
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V
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--
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A
S
F
I
G
N
P
P
T
--
N
F
L
R
D
F
-------------
S
V
S
V
-------------------
E
------------------------
N
K
----------------
Q
T
I
L
K
----------
R
DD
V
I
I
K
L
P
E
P
V
D
V
KLK
E
V
V
V
G
--
I
R
P
E
H
C
R
I
S
R
E
R
------
V
E
-----
N
S
I
P
G
V
V
-----------
Y
V
V
E
P
L
G
R
--
D
I
I
V
N
V
-----------------------------
108
HHSearch
82.70
38%
-120
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-355]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
--
P
K
M
N
F
L
P
V
K
-------------
V
T
A
T
-------------------
A
ID
Q
V
Q
V
E
L
PMPNR
Q
Q
V
W
L
PVESRD
V
Q
----------------
V
G
A
N
M
----------
S
-------------------
L
G
--
I
R
P
E
H
L
L
P
S
D
I
A
------
D
V
-----
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
---
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
--
21
PsiBlast_CBE
82.26
50%
-130
- C1 -
1Z47
1
?
B:
[15-252]
-
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
-
A
--
R
S
V
---
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
V
----
T
-----
D
-----
L
P
P
Q
K
R
N
----------------
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
-
S
-
Y
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
--
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
--
S
--
N
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
81.80
33%
-114
- C1 -
1OXX
25
?
K:
[1-350]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
GK
V
V
A
L
--
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
------
R
L
V
----
A
-----
S
NGKLI
V
P
P
E
D
R
K
----------------
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
---
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
-
H
-
V
L
-
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
--
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
G
K
-------------
V
T
N
E
-------------------
G
VVIGSLRFPV--------------
S
V
----------------
S
S
D
R
A
----------
I
-------------------
I
G
--
I
R
P
E
D
V
K
L
S
K
D
V
IKDDSW
I
L
-----
V
-
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
--
E
E
E
I
F
T
---
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
--
3
PsiBlast_PDB
81.42
50%
-131
- C1 -
1Z47
1
?
A:
[15-252]
-
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
-
A
--
R
S
V
---
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
R
V
----
T
-----
D
-----
L
P
P
Q
K
R
N
----------------
V
G
L
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
-
S
-
Y
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
--
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
--
S
--
N
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.04
46%
-129
- C1 -
2IT1
-
?
A:
[1-245]
-
M
V
E
I
K
L
E
N
I
V
K
K
F
--
G
-
N
--
F
T
A
L
--
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
------
K
D
V
----
T
-----
E
-----
L
P
P
K
D
R
N
----------------
V
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
E
L
R
---
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
-
K
-
L
L
-
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
--
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
--
N
F
V
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
80.91
32%
-115
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
--
V
V
A
L
--
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
------
R
L
V
----
A
SNGKL
I
-----
V
P
P
E
D
R
K
----------------
I
G
M
V
F
Q
--
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
T
N
M
---
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
-
H
-
V
L
-
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
--
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
--
I
--
N
E
L
E
G
K
-------------
V
T
N
E
-------------------
G
------------------------
V
V
----------------
I
G
S
L
R
FPVSVSSDRA
I
-------------------
I
G
--
I
R
P
E
D
V
K
L
S
K
D
V
IKDDSW
I
L
-----
V
-
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
--
E
E
E
I
F
T
Y
S
D
H
P
---
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
14
PsiBlast_PDB
80.51
46%
-130
- C1 -
3PUV
5
MALK_ECOLI
A:
[2-236]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.32
50%
-129
- C1 -
1V43
-
?
A:
[10-250]
-
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
-
N
--
F
T
A
V
--
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
------
R
D
V
----
T
-----
Y
-----
L
P
P
K
D
R
N
----------------
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
---
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
-
E
-
L
L
-
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
--
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.84
46%
-129
- C1 -
3PUX
5
MALK_ECOLI
A:
[2-236]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.34
46%
-130
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-236]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.95
46%
-130
- C1 -
3PUW
5
MALK_ECOLI
A:
[2-236]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
77.92
35%
-118
- C1 -
3D31
2
?
A:
[1-327]
---
M
I
E
I
E
S
L
S
R
K
W
--
K
-
N
--
F
S
L
---
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
------
K
D
V
----
T
-----
D
-----
L
S
P
E
K
H
D
----------------
I
A
F
V
Y
Q
--
N
Y
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
-
M
R
M
K
---
K
I
K
D
P
---
K
R
V
L
D
T
A
R
D
L
K
I
E
-
H
-
L
L
-
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
--
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
G
F
--
E
--
N
V
L
K
G
R
-------------
V
I
S
A
-------------------
E
------------------------
Q
G
L
L
R
I
R
V
GE
V
V
I
D
A
A
G
D
M
E
V
G
D
----------
Q
-------------------
V
Y
A
F
L
R
P
E
N
I
A
L
S
K
S
S
------
T
Q
SSIR
N
S
-
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
-
C
G
V
--
P
L
N
V
L
I
T
R
R
S
A
E
E
M
---------------------
28
PsiBlast_CBE
77.80
46%
-128
- C1 -
3PUW
5
MALK_ECOLI
B:
[2-246]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.79
46%
-130
- C1 -
3PUY
3
MALK_ECOLI
A:
[2-236]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
--
G
-
E
--
V
V
V
S
--
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
R
M
----
N
-----
D
-----
T
P
P
A
E
R
G
----------------
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
-
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
--
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
76.39
43%
-127
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-240]
----
L
H
I
G
H
L
S
K
S
F
--
Q
-
N
--
T
P
V
L
--
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
T
I
----
F
-----
S
KNTN-
L
P
V
R
E
R
R
----------------
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
-
L
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
--
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.52
43%
-127
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-245]
----
L
H
I
G
H
L
S
K
S
F
--
Q
-
N
--
T
P
V
L
--
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
T
I
----
F
-----
S
KN
T
N
-
L
P
V
R
E
R
R
----------------
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
-
L
A
-
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
--
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
67.09
36%
-115
- C1 -
2OLK
1
?
D:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
66.42
34%
-116
- C1 -
4YMV
1
?
A:
[1-229]
---
M
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
NNGK
V
-----
N
-----
I
N
K
V
R
Q
K
----------------
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
66.24
36%
-118
- C1 -
3C4J
4
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
65.66
36%
-116
- C1 -
3C41
3
?
J:
[1-238]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
65.64
36%
-116
- C1 -
3C41
3
?
K:
[1-238]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
65.55
36%
-114
- C1 -
2OLK
1
?
C:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
65.47
36%
-115
- C1 -
3C4J
3
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
65.34
36%
-113
- C1 -
2OLK
1
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAK
D
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
65.27
36%
-113
- C1 -
2Q0H
4
?
A:
[23-259]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.22
37%
-114
- C1 -
4U00
3
?
A:
[4-238]
---
I
I
R
I
R
N
L
H
K
W
F
--
G
-
P
--
L
H
V
L
--
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSV---
K
D
D
----
R
-----
A
-----
L
R
E
I
R
R
E
----------------
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
---
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
-
D
-
Q
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
--
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
65.19
36%
-114
- C1 -
2OLK
2
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.98
36%
-116
- C1 -
2OLJ
4
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.56
36%
-110
- C1 -
2OLJ
3
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.45
36%
-113
- C1 -
2Q0H
4
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
--
L
E
V
L
--
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
N
L
KAKD
T
-----
N
-----
L
N
K
V
R
E
E
----------------
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
-
D
-
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
64.38
34%
-117
- C1 -
4YMV
1
?
J:
[1-229]
---
M
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
NNGK
V
-----
N
-----
I
N
K
V
R
Q
K
----------------
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
64.28
32%
-114
- C1 -
1B0U
4
HISP_SALTY
A:
[12-253]
---------
L
H
K
R
Y
--
G
-
G
--
H
E
V
L
--
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
------
Q
N
-----
I
-----
N
-----
L
V
R
D
K
D
G
QLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
---
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
-
E
-
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
---
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
64.21
34%
-119
- C1 -
4YMU
2
?
J:
[1-229]
---
M
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
NNGK
V
-----
N
-----
I
N
K
V
R
Q
K
----------------
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
63.58
34%
-118
- C1 -
4YMU
2
?
A:
[1-229]
---
M
I
F
V
N
D
V
Y
K
N
F
--
G
-
S
--
L
E
V
L
--
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
K
I
NNGK
V
-----
N
-----
I
N
K
V
R
Q
K
----------------
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-
D
-
K
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
--
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
58.21
37%
-118
- C1 -
4MKI
4
ECFA2_CALS4
B:
[23-226]
------------------
A
--
T
V
A
L
--
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
------
I
D
I
TDKK
V
-----
S
-----
L
K
D
I
R
K
Q
----------------
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
---
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
-
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
--
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
56.96
37%
-120
- C1 -
4MKI
4
ECFA2_CALS4
A:
[23-226]
------------------
A
--
T
V
A
L
--
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
------
I
D
I
TDKK
V
-----
S
-----
L
K
D
I
R
K
Q
----------------
V
G
L
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
-
P
S
N
L
---
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
-
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
--
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
52.82
32%
-111
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
--
E
I
I
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDL
D
D
D
----
E
-----
L
-----
T
K
I
R
R
D
K
----------------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
52.34
33%
-111
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
--
E
I
I
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDL
D
D
D
----
E
-----
L
-----
T
K
I
R
R
D
K
----------------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
51.69
33%
-117
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
---
M
V
K
L
K
N
V
T
K
T
Y
KM
G
-
E
--
E
I
I
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDL
D
D
D
----
E
-----
L
-----
T
K
I
R
R
D
K
----------------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
50.36
32%
-112
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
KM
G
-
E
--
E
I
I
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
IKTNDL
D
D
D
----
E
-----
L
-----
T
K
I
R
R
D
K
----------------
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
--
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------