@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3528: (2016-02-18 )
MSEDNFDDEFDGSLPSGPRHPMARRFRGYLPVVVDVETGGFNSATDALLEIAATTVGMDEKGFLFPEHTYFFRIEPFEGANIEPAALEFTGIKLDHPLRMAVQEEAALTEIFRGIRKALKANGCKRAILVGHNSSFDLGFLNAAVARTGIKRNPFHPFSSFDTATLAGLAYGQTVLAKACQAAGMEFDNREAHSARYDTEKTAELFCGIVNRWKEMGGWMDDDD
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........-100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEDNFDDEFDGSLPSGPRH
P
M
A
R
R
FRGYL
P
V
V
V
D
V
ETGGFN
S
A
T
D
A
L
L
E
I
A
A
T
TVGMDEK
G
F
LFPE
H
T
Y
F
F
R
IEPFEGANIEP
A
A
L
E
F
T
G
I
KLDH
P
L
R
-
M
A
V
Q
E
E
A
A
L
T
E
I
F
R
G
I
R
K
A
L
K
ANGC
K
R
A
I
L
V
GHNSSF
D
L
G
F
L
N
A
A
V
A
RTGIKRNPFHPFSSF
D
T
A
T
L
A
G
L
A
Y
G
Q
T
V
L
A
K
A
C
Q
A
AGMEFDNREAHSARYD
T
E
K
T
A
E
L
F
C
G
I
V
N
R
W
K
E
MGGWMDDDD
59
HHSearch
99.14
100%
-104
- C1 -
2F96
1
RNT_PSEAE
A:
[19-220]
------------------
R
H
P
M
A
R
R
F
R
G
Y
L
P
V
V
V
D
V
E
T
G
G
F
N
S
A
T
D
A
L
L
E
I
A
A
T
T
V
G
M
D
E
K
G
F
L
F
P
E
H
T
Y
F
F
R
I
E
P
F
E
G
A
N
I
E
P
A
A
L
E
F
T
G
I
K
L
D
H
P
L
R
-
M
A
V
Q
E
E
A
A
L
T
E
I
F
R
G
I
R
K
A
L
K
A
N
G
C
K
R
A
I
L
V
G
H
N
S
S
F
D
L
G
F
L
N
A
A
V
A
R
T
G
I
K
R
N
P
F
H
P
F
S
S
F
D
T
A
T
L
A
G
L
A
Y
G
Q
T
V
L
A
K
A
C
Q
A
A
G
M
E
F
D
N
R
E
A
H
S
A
R
Y
D
T
E
K
T
A
E
L
F
C
G
I
V
N
R
W
K
E
M
G
G
W
M
----
1
PsiBlast_PDB
98.58
97%
-104
- C1 -
2F96
1
RNT_PSEAE
A:
[19-219]
------------------
R
H
P
M
A
R
R
F
R
G
Y
L
P
V
V
V
D
V
E
T
G
G
F
N
S
A
T
D
A
L
L
E
I
A
A
T
T
V
G
M
D
E
K
G
F
L
F
P
E
H
T
Y
F
F
R
I
E
P
F
E
G
A
N
I
E
P
A
A
L
E
F
T
G
I
K
L
D
H
P
L
R
-
M
A
V
Q
E
E
A
A
L
T
E
I
F
R
G
I
R
K
A
L
K
A
N
G
C
K
R
A
I
L
V
G
H
N
S
S
F
D
L
G
F
L
N
A
A
V
A
R
T
G
I
K
R
N
P
F
H
P
F
S
S
F
D
T
A
T
L
A
G
L
A
Y
G
Q
T
V
L
A
K
A
C
Q
A
A
G
M
E
F
D
N
R
E
A
H
S
A
R
Y
D
T
E
K
T
A
E
L
F
C
G
I
V
N
R
W
K
E
M
G
G
W
-----
33
PsiBlast_CBE
89.16
63%
-102
- C1 -
3NH1
4
RNT_ECOLI
C:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
60
HHSearch
89.11
60%
-103
* C1 *
3V9W
5
RNT_ECOLI
A:
[29-230]
--------------------
G
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
-
P
D
R
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
P
L
S
--
3
PsiBlast_PDB
88.80
63%
-100
- C1 -
3NH1
4
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
26
PsiBlast_CBE
88.79
63%
-102
- C1 -
3V9X
4
RNT_ECOLI
C:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
32
PsiBlast_CBE
88.71
63%
-101
- C1 -
3NH1
4
RNT_ECOLI
D:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
15
PsiBlast_PDB
88.59
62%
-102
- C1 -
3V9W
5
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
37
PsiBlast_CBE
88.42
62%
-102
- C1 -
3V9W
5
RNT_ECOLI
D:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
34
PsiBlast_CBE
88.14
63%
-99
- C1 -
3NH1
4
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
38
PsiBlast_CBE
88.13
62%
-103
- C1 -
3V9W
5
RNT_ECOLI
C:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
12
PsiBlast_PDB
87.64
62%
-104
- C1 -
3NGY
1
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
14
PsiBlast_PDB
87.59
62%
-101
- C1 -
3V9U
5
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
6
PsiBlast_PDB
87.51
63%
-100
- C1 -
3V9X
4
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
25
PsiBlast_CBE
87.46
63%
-102
- C1 -
3V9X
4
RNT_ECOLI
D:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
27
PsiBlast_CBE
87.45
63%
-97
- C1 -
3V9X
4
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
9
PsiBlast_PDB
87.31
63%
-103
- C1 -
4KAZ
3
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
29
PsiBlast_CBE
87.28
63%
-101
- C1 -
3NH2
3
RNT_ECOLI
F:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
-----
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
16
PsiBlast_PDB
87.24
62%
-101
- C1 -
3VA3
3
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
11
PsiBlast_PDB
87.01
63%
-101
- C1 -
4KB1
4
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
39
PsiBlast_CBE
86.83
62%
-101
- C1 -
3V9W
5
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
21
PsiBlast_CBE
86.74
63%
-103
- C1 -
4KB1
4
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
5
PsiBlast_PDB
86.71
63%
-100
- C1 -
3V9S
4
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
7
PsiBlast_PDB
86.68
63%
-103
- C1 -
3V9Z
4
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
2
PsiBlast_PDB
86.54
63%
-100
- C1 -
3NH0
2
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
10
PsiBlast_PDB
86.45
63%
-101
- C1 -
4KB0
4
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
4
PsiBlast_PDB
86.38
63%
-104
- C1 -
3NH2
2
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
-----
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
22
PsiBlast_CBE
86.36
63%
-101
- C1 -
4KB0
4
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
24
PsiBlast_CBE
86.20
63%
-101
- C1 -
3V9Z
3
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
8
PsiBlast_PDB
86.17
63%
-101
- C1 -
3VA0
3
RNT_ECOLI
A:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
30
PsiBlast_CBE
86.16
63%
-100
- C1 -
3NH2
3
RNT_ECOLI
E:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
41
PsiBlast_CBE
86.06
62%
-101
- C1 -
3V9U
4
RNT_ECOLI
C:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
36
PsiBlast_CBE
85.80
62%
-99
- C1 -
3VA3
3
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
28
PsiBlast_CBE
85.77
63%
-100
- C1 -
3V9S
3
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
42
PsiBlast_CBE
85.64
62%
-100
- C1 -
3V9U
5
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
23
PsiBlast_CBE
85.51
63%
-98
- C1 -
3VA0
4
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
35
PsiBlast_CBE
85.18
63%
-100
- C1 -
3NH0
2
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
40
PsiBlast_CBE
85.01
62%
-98
- C1 -
3V9U
5
RNT_ECOLI
D:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
G
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----
31
PsiBlast_CBE
84.71
63%
-103
- C1 -
3NH2
3
RNT_ECOLI
B:
[30-227]
---------------------
L
C
D
R
F
R
G
F
Y
P
V
V
I
D
V
E
T
A
G
F
N
A
K
T
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
G
W
L
M
P
D
T
T
L
H
F
H
V
E
P
F
V
G
A
N
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
P
D
R
-
G
A
V
S
E
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
G
C
N
R
A
I
M
V
A
H
N
A
N
F
D
H
S
F
M
M
A
A
A
E
R
A
S
L
K
R
N
P
F
H
P
F
A
T
F
D
T
A
A
L
A
G
L
A
L
G
Q
T
V
L
S
K
A
C
Q
T
A
G
M
D
F
D
S
T
Q
A
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
L
G
G
W
-----