@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3798: (2016-02-20 )
MIQSKLPNVGTTIFTRMSQLAAECGAINLSQGFPDFDGPPELREAVGRHIAAGHNQYAPMTGLPALREQVAKKIEQFYGRRVSADSEVTITPGATEAIFSAIQALVHPGDEVVVLDPSYDSYEPSVQLAGGRCVHVPLALPDFSIDWQRMAEAIGPRTRLVIINTPHNPSGALISREELDRLAALIRDRDIYLISDEVYEHLVFDGVAHTSVLSHDELYPRSFVVSSFGKTYHVTGWKTGYVVAPPALSAELRKVHQYVNFCGVTPLQWALADYMAGHPEHLRQLPGFYQAKRDLFCDLLLDSRFRFTRAPGTYFQCVDYSAIRPDLDDVAMAEWLTREHGVAAIPVSVFYEKAPDAMRLVRFCYAKREETLRQAAEKLCAI
Atome Classification :
(47 SA)
.........10........20..-......30........40........-50-.---..---.....60........70........80..-.-.....90........100.......110.......120.......130-.......-----------.140---------.---------.......150.......160.......170.......180.......190.......200.......210.......220-........230.......240.......250.......260.......270...------..-------.-------.------280..-------...----------...290------........300.......310.......320..---.---------...---------.330-----..--------.....340.......350---.--..--.--...-----.360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIQSKLPN
V
G
T
T
I
F
T
R
M
S
Q
L
A
A
E-CGAINLSQGFPDFDG
P
P
E
L
R
E
A
V
G
R
H
-
I
A-A---GH---NQYAPMTG
L
P
A
L
R
E
Q
V
A
K
K
I
E
Q
F
YGRRVS-A-DS
E
V
T
ITPG
A
T
E
A
I
F
S
A
I
Q
A
LVHPG
D
E
V
V
V
LDPSYDSYEP
S
V
Q
LAG
G
--
R
C
V
HVPL-----------ALP----------D---------FSI
D
W
Q
R
M
A
E
AIGPR
T
R
L
V
I
I
NTPHNPSGALI
S
R
E
E
L
D
R
L
A
A
L
IRDR
D
I
Y
L
I
S
D
E
V
Y
E
H
L
V
FDGVAHTSVLSHDELY
P
-
R
-
S
F
V
V
S
SFG
K
T
Y
H
VTGWKT
G
Y
V
VAPP
A
L
S
A
E
L
R
K
V
H
Q
Y
V
N
F
CGV
T
P
L
Q
W
A
L
A
D
Y
M------AG-------
H
-------
P
------
E
-
H
L
R
-------QLP----------
G
F
Y
Q
A
-------
K
R
D
L
F
C
D
L
L
LDSR
F
R
F
TRAPG
T
Y
F
Q
CV
D
Y
S
AIR---P---------
D
L
D
---------
D
V
A
M
-----
A
E
--------
W
L
T
REHGVAAI
P
V
S
V
F
Y
----E--KA--P--
D
A
M
-----
R
L
V
R
F
C
Y
A
K
R
E
E
T
L
R
Q
A
A
E
K
LCAI
21
PsiBlast_CBE
97.44
55%
-120
- C1 -
1U08
2
YBDL_ECOLI
B:
[9-383]
--
Q
S
K
L
P
----
T
I
F
T
Q
M
S
A
L
A
Q
Q
-
H
Q
A
I
N
L
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F
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---
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A
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T
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R
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Y
G
Y
Q
P
D
-
A
-
D
S
D
I
T
V
T
A
G
A
T
E
A
L
Y
A
A
I
T
A
L
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N
G
D
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V
I
C
F
D
P
S
Y
D
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Y
A
P
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G
--
I
V
K
R
M
A
L
-----------
Q
P
P
----------
H
---------
F
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D
W
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E
F
A
A
L
L
S
E
R
T
R
L
V
I
L
N
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P
H
N
P
S
A
T
V
W
Q
Q
A
D
F
A
A
L
W
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A
I
A
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H
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I
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I
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Y
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N
F
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Q
G
H
A
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V
L
A
H
P
Q
L
R
E
-
R
-
A
V
A
V
S
S
F
G
K
T
Y
H
M
T
G
W
K
V
G
Y
C
V
A
P
A
P
I
S
A
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I
R
K
V
H
Q
Y
L
T
F
S
V
N
T
P
A
Q
L
A
L
A
D
M
L
------
R
A
-------
E
-------
P
------
E
-
H
Y
L
-------
A
L
P
----------
D
F
Y
R
Q
-------
K
R
D
I
L
V
N
A
L
N
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S
R
L
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I
L
P
C
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G
T
Y
F
L
L
V
D
Y
S
A
V
S
-------------
T
L
D
---------
D
V
E
F
-----
C
Q
--------
W
L
T
Q
E
H
G
V
A
A
I
P
L
S
V
F
C
----
A
--
D
---
P
--
F
P
H
-----
K
L
I
R
L
C
F
A
K
K
E
S
T
L
L
A
A
A
E
R
L
---
1
PsiBlast_PDB
95.83
55%
-118
- C1 -
1U08
2
YBDL_ECOLI
A:
[9-383]
--
Q
S
K
L
P
Q
L
G
T
T
I
F
T
Q
M
S
A
L
A
Q
Q
-
H
Q
A
I
N
L
S
Q
G
F
P
D
F
D
G
P
R
Y
L
Q
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L
A
H
H
-
V
A
-
Q
---
G
A
---
N
Q
Y
A
P
M
T
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V
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A
L
R
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A
I
A
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R
L
Y
G
Y
Q
P
D
-
A
-
D
S
D
I
T
V
T
A
G
A
T
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A
L
Y
A
A
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T
A
L
V
R
N
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D
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V
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D
P
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Y
D
S
Y
A
P
A
I
A
L
S
G
G
--
I
V
K
R
M
A
L
-----------
Q
P
P
----------
H
---------
F
R
V
D
W
Q
E
F
A
A
L
L
S
E
R
T
R
L
V
I
L
N
T
P
H
N
P
S
A
T
V
W
Q
Q
A
D
F
A
A
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W
Q
A
I
A
G
H
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D
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V
Y
E
H
I
N
F
S
Q
Q
G
H
A
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V
L
A
H
P
Q
L
R
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-
R
-
A
V
A
V
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F
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Y
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M
T
G
W
K
V
G
Y
C
V
A
P
A
P
I
S
A
E
I
R
K
V
H
Q
Y
L
T
F
S
V
N
T
P
A
Q
L
A
L
A
D
M
L
------
R
A
-------
E
-------
P
------
E
-
H
Y
L
-------
A
L
P
----------
D
F
Y
R
Q
-------
K
R
D
I
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V
N
A
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L
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Y
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A
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S
-------------
T
L
D
---------
D
V
E
F
-----
C
Q
--------
W
L
T
Q
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H
G
V
A
A
I
P
L
S
V
F
C
----
A
--
D
---
P
--
F
P
H
-----
K
L
I
R
L
C
F
A
K
K
E
S
T
L
L
A
A
A
E
R
L
---
81
HHSearch
95.21
54%
-119
- C1 -
1U08
2
YBDL_ECOLI
A:
[10-385]
---
S
K
L
P
Q
L
G
T
T
I
F
T
Q
M
S
A
L
A
Q
Q
-
H
Q
A
I
N
L
S
Q
G
F
P
D
F
D
G
P
R
Y
L
Q
E
R
L
A
H
H
-
V
A
-
Q
---
G
A
---
N
Q
Y
A
P
M
T
G
V
Q
A
L
R
E
A
I
A
Q
K
T
E
R
L
Y
G
Y
Q
P
D
-
A
D
S
-
D
I
T
V
T
A
G
A
T
E
A
L
Y
A
A
I
T
A
L
V
R
N
G
D
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V
I
C
F
D
P
S
Y
D
S
Y
A
P
A
I
A
L
S
G
G
--
I
V
K
R
M
A
L
-----------
Q
P
P
----------
H
---------
F
R
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D
W
Q
E
F
A
A
L
L
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R
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L
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N
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A
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W
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Q
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A
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A
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H
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Y
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N
F
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Q
Q
G
H
A
S
V
L
A
H
P
Q
L
R
E
-
R
-
A
V
A
V
S
S
F
G
K
T
Y
H
M
T
G
W
K
V
G
Y
C
V
A
P
A
P
I
S
A
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K
V
H
Q
Y
L
T
F
S
V
N
T
P
A
Q
L
A
L
A
D
M
L
------
R
A
-------
E
-------
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------
E
-
H
Y
L
-------
A
L
P
----------
D
F
Y
R
Q
-------
K
R
D
I
L
V
N
A
L
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L
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L
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Y
F
L
L
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D
Y
S
A
V
S
-------------
T
L
D
---------
D
V
E
F
-----
C
Q
--------
W
L
T
Q
E
H
G
V
A
A
I
P
L
S
V
F
C
----
A
--
D
P
--
F
---
P
H
-----
K
L
I
R
L
C
F
A
K
K
E
S
T
L
L
A
A
A
E
R
L
R
Q
-
2
PsiBlast_PDB
79.52
38%
-112
- C1 -
2O0R
3
DAPC_MYCTU
A:
[5-392]
---
S
R
L
R
P
Y
A
T
T
V
F
A
E
M
S
A
L
A
T
R
-
I
G
A
V
N
L
G
Q
G
F
P
D
E
D
G
P
P
K
M
L
Q
A
A
Q
D
A
-
I
A
-
G
---
G
V
---
N
Q
Y
P
P
G
P
G
S
A
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R
A
I
A
A
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R
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D
Y
D
-
P
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L
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A
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A
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A
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------------
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----------
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GR
G
------
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A
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A
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A
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T
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T
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A
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A
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A
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L
A
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D
G
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W
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W
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A
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A
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A
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D
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-----
C
A
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A
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A
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A
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H
L
V
R
F
T
F
C
K
R
D
D
T
L
D
E
A
I
R
R
L
S
V
L
101
HHSearch
78.97
40%
-110
- C1 -
2O0R
3
DAPC_MYCTU
A:
[7-391]
-----
L
R
P
Y
A
T
T
V
F
A
E
M
S
A
L
A
T
R
-
I
G
A
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N
L
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D
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A
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G
A
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A
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A
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A
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------
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T
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A
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W
V
A
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L
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----------
N
S
L
R
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R
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F
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A
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R
P
L
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-------------
Y
D
D
---------
S
T
E
F
-----
C
A
--------
A
L
P
E
K
V
G
V
A
A
I
P
M
S
A
F
C
----
D
--
P
----AD
V
W
N
-----
H
L
V
R
F
T
F
C
K
R
D
D
T
L
D
E
A
I
R
R
L
S
V
-
86
HHSearch
74.02
34%
-111
- C1 -
1YIZ
3
?
A:
[20-424]
------
Q
G
S
T
K
S
V
W
V
E
Y
I
Q
L
A
A
Q
-
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
-
A
N
-
S
PDP
L
A
---
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
-
T
-
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
--
I
P
R
F
I
P
L
-----------
K
P
N
----------
K
TGGTISSAD
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
V
G
F
------
E
T
-------
E
L
K
R
LKSP
E
------
C
-
Y
F
N
-------
S
I
S
----------
G
E
L
M
A
-------
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
---
S
KVDLTQETD
A
R
K
---------
D
Y
R
F
-----
T
K
--------
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
----
S
--
E
P
NK
H
--
L
G
E
-----
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
R
K
-
33
PsiBlast_CBE
73.39
33%
-115
- C1 -
4WLH
2
KAT1_HUMAN
B:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
K
PLG-------
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSS
Y
F
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
P
---------
D
L
P
GAVDEP
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
30
PsiBlast_CBE
72.83
33%
-112
- C1 -
4WLJ
2
KAT1_HUMAN
B:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGLG------
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSSYFV
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
RKM
P
---------
D
L
P
GAVDEPY--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
36
PsiBlast_CBE
71.94
33%
-112
- C1 -
3FVS
2
KAT1_HUMAN
B:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGPIQNGELG
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSSYFV
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
RKM
P
---------
D
L
P
GAVDEPY--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
82
HHSearch
71.80
34%
-110
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[3-408]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
-
A
F
I
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
-
E
-
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
-----------
R
S
K
PTDGMKWTSS
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
------
W
I
D
I
K
R
M
DD
P
-------
E
------
C
-
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
DLSDMNSD-
E
P
Y
---------
D
Y
K
F
-----
V
K
--------
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
--
S
K
--
S
KP
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
I
F
R
A
-
35
PsiBlast_CBE
71.71
33%
-112
- C1 -
3FVU
6
KAT1_HUMAN
B:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGPIQNGELG
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSSYFV
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
RKM
P
---------
D
L
P
GAVDEPY--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
14
PsiBlast_PDB
71.68
33%
-114
- C1 -
1W7M
1
KAT1_HUMAN
A:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGPGELG---
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSSYF
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
L
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
KM
P
---------
D
L
P
GAVDE
P
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
34
PsiBlast_CBE
71.00
33%
-112
- C1 -
3FVX
2
KAT1_HUMAN
B:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGPIQNGELG
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSSYFV
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
RKM
P
---------
D
L
P
GAVDEPY--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
19
PsiBlast_PDB
70.93
33%
-112
- C1 -
4WP0
-
KAT1_HUMAN
A:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
F
M
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
K
P
GLG------
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSS
Y
F
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
P
---------
D
L
P
G
A
V
DEP
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
15
PsiBlast_PDB
70.68
33%
-113
- C1 -
3FVS
2
KAT1_HUMAN
A:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
K
P
G
PIQNG
E
L
G
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPS
S
Y
F
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
P
---------
D
L
P
G
AVDE
P
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
17
PsiBlast_PDB
70.64
33%
-114
- C1 -
3FVX
2
KAT1_HUMAN
A:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGPIQNG
E
L
G
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPS
S
Y
F
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
P
---------
D
L
P
G
AVDE
P
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
13
PsiBlast_PDB
70.40
33%
-111
- C1 -
1W7N
1
KAT1_HUMAN
A:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
KPGPGELG---
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPSS
Y
F
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
L
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
P
---------
D
L
P
GAVDEP
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
12
PsiBlast_PDB
69.69
38%
-113
- C1 -
1V2F
4
?
A:
[13-367]
-----------
S
I
F
P
R
M
S
G
L
A
Q
R
-
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
-
L
G
-
R
----
Q
---
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
F
A
------
V
E
-
P
-
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
K
A
R
L
V
R
L
D
L
-----------
T
P
E
----------
G
---------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
----
R
L
R
E
F
A
P
E
R
-
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
--------------------------------
K
L
A
-------
R
R
E
----------
G
F
Y
E
A
L
R
E
G
Y
R
R
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
-------
P
---------
G
W
D
---------
A
F
R
L
-----
V
E
------------
E
A
R
V
A
L
I
P
A
S
A
F
Y
----
L
--
E
D
--
P
--
P
K
------
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
5
PsiBlast_PDB
69.59
33%
-115
- C1 -
3E2F
7
KAT3_MOUSE
A:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
R
S
K
P
TDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
I
K
R
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
9
PsiBlast_PDB
69.57
32%
-113
- C1 -
2R5E
2
?
A:
[25-422]
-----------
S
V
W
V
E
Y
I
Q
L
A
A
Q
-
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
-
A
N
-
S
---
P
D
PLA
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
-
P
-
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
--
I
P
R
F
I
P
L
K
P
NKTGGTI--
S
S
A
----------
D
---------
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
---------
V
G
-------
F
-------
E
------
T
-
E
L
K
-------
R
L
K
SPECYFNS
I
S
G
E
L
M
A
-------
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
---
S
---------
K
V
D
LTQETDAR
K
D
Y
R
F
-----
T
K
--------
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
----
S
--
E
P
--
N
--
K
H
L
GE---
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
---
11
PsiBlast_PDB
69.29
38%
-114
- C1 -
1V2E
4
?
A:
[13-367]
-----------
S
I
F
P
R
M
S
G
L
A
Q
R
-
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
-
L
G
-
R
----
Q
---
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
F
A
------
V
E
-
P
-
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
KA
R
L
V
R
L
D
L
-----------
T
P
E
----------
G
---------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
----
R
L
R
E
F
A
P
E
R
-
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
--------------------------------
K
L
A
-------
R
R
E
----------
G
F
Y
E
A
L
R
E
G
Y
R
R
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
-------
P
---------
G
W
D
---------
A
F
R
L
-----
V
E
------------
E
A
R
V
A
L
I
P
A
S
A
F
Y
----
L
--
E
D
--
P
--
P
K
------
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
26
PsiBlast_CBE
69.17
33%
-115
- C1 -
3E2F
5
KAT3_MOUSE
B:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
RSKPTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
WIDIKR
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
PYDYKFVK
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
16
PsiBlast_PDB
68.95
33%
-112
- C1 -
3FVU
7
KAT1_HUMAN
A:
[9-415]
----
R
L
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
E
-
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
-
P
P
D
F
A
V
E
A
F
Q
H
-
A
V
-
S
---
G
D
FML
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
-
P
-
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
--
R
P
V
F
V
S
L
K
P
G
P
IQNG
E
L
G
S
S
S
----------
N
---------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
E
-
R
-
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
A
E
S
F
------
E
R
-------
E
-------
Q
------
L
-
L
F
R
QPS
S
Y
F
V
Q
F
P
----------
Q
A
M
Q
R
-------
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
P
---------
D
L
P
GAVDE
P
Y
--
D
R
R
F
-----
V
K
--------
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
SVPH
Q
--
K
H
--
F
--
D
-------
H
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
---
28
PsiBlast_CBE
68.92
38%
-112
- C1 -
1V2F
4
?
B:
[13-367]
-----------
S
I
F
P
R
M
S
G
L
A
Q
R
-
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
-
L
G
-
R
----
Q
---
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
F
A
------
V
E
-
P
-
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
KA
R
L
V
R
L
D
L
-----------
T
P
E
----------
G
---------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
----
R
L
R
E
F
A
P
E
R
-
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
--------------------------------
K
L
A
-------
R
R
E
----------
G
F
Y
E
A
LREGYRR
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
-------
P
---------
G
W
D
---------
A
F
R
L
-----
V
E
------------
E
A
R
V
A
L
I
P
A
S
A
F
Y
----
L
--
E
D
--
P
--
P
K
------
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
7
PsiBlast_PDB
68.65
32%
-112
- C1 -
1YIY
5
?
A:
[25-422]
-----------
S
V
W
V
E
Y
I
Q
L
A
A
Q
-
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
-
A
N
-
S
---
P
D
PLA
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
-
P
-
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
--
I
P
R
F
I
P
L
K
P
N
KTGGTI--
S
S
A
----------
D
---------
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
---------
V
G
-------
F
-------
E
------
T
-
E
L
K
-------
R
L
K
SPECYFNS
I
S
G
E
L
M
A
-------
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
---
S
---------
K
V
D
LTQETDAR
K
D
Y
R
F
-----
T
K
--------
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
----
S
--
E
P
--
N
--
K
H
L
GE---
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
---
8
PsiBlast_PDB
68.23
32%
-112
- C1 -
2R5C
1
?
B:
[25-422]
-----------
S
V
W
V
E
Y
I
Q
L
A
A
Q
-
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
-
A
N
-
S
---
P
D
PLA
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
-
P
-
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
--
I
P
R
F
I
P
L
K
P
NKTGGTI--
S
S
A
----------
D
---------
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
---------
V
G
-------
F
-------
E
------
T
-
E
L
K
-------
R
L
K
SPECYFNS
I
S
G
E
L
M
A
-------
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
---
S
---------
K
V
D
LTQETDAR
K
D
Y
R
F
-----
T
K
--------
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
----
S
--
E
P
--
N
--
K
H
L
GE---
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
---
22
PsiBlast_CBE
67.99
33%
-114
- C1 -
3E2Y
6
KAT3_MOUSE
B:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
RSKPTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
WIDIKR
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
PYDYKFVK
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
24
PsiBlast_CBE
67.89
32%
-113
- C1 -
1YIY
4
?
B:
[25-422]
-----------
S
V
W
V
E
Y
I
Q
L
A
A
Q
-
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
-
A
N
-
S
---
P
D
PLA
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
-
P
-
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
--
I
P
R
F
I
P
L
KPNKTGGTI--
S
S
A
----------
D
---------
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
---------
V
G
-------
F
-------
E
------
T
-
E
L
K
-------
R
L
K
SPECYFNSIS
G
E
L
M
A
-------
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
---
S
---------
K
V
D
LTQETDARK
D
Y
R
F
-----
T
K
--------
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
----
S
--
E
P
--
N
--
K
H
L
GE---
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
---
6
PsiBlast_PDB
67.86
33%
-113
- C1 -
2ZJG
5
KAT3_MOUSE
A:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
R
S
K
PTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
IKR
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
23
PsiBlast_CBE
67.84
32%
-112
- C1 -
2R5E
2
?
B:
[25-422]
-----------
S
V
W
V
E
Y
I
Q
L
A
A
Q
-
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
-
A
N
-
S
---
P
D
PLA
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
-
P
-
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
--
I
P
R
F
I
P
L
KPNKTGGTI--
S
S
A
----------
D
---------
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
---------
V
G
-------
F
-------
E
------
T
-
E
L
K
-------
R
L
K
SPECYFNSIS
G
E
L
M
A
-------
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
L
D
---
S
---------
K
V
D
LTQETDARK
D
Y
R
F
-----
T
K
--------
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
----
S
--
E
P
--
N
--
K
H
L
GE---
D
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
---
27
PsiBlast_CBE
67.22
33%
-113
- C1 -
2ZJG
6
KAT3_MOUSE
B:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
RSKPTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
WIDIKR
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
PYDYKFVK
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
3
PsiBlast_PDB
67.14
33%
-112
- C1 -
3E2Z
5
KAT3_MOUSE
B:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
R
S
K
PTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
I
K
R
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
4
PsiBlast_PDB
66.72
33%
-113
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
R
S
K
PTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
I
K
R
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
29
PsiBlast_CBE
66.08
38%
-111
- C1 -
1V2E
4
?
B:
[13-367]
-----------
S
I
F
P
R
M
S
G
L
A
Q
R
-
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
-
L
G
-
R
----
Q
---
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
F
A
------
V
E
-
P
-
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
KA
R
L
V
R
L
D
L
-----------
T
P
E
----------
G
---------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
----
R
L
R
E
F
A
P
E
R
-
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
--------------------------------
K
L
A
-------
R
R
E
----------
G
F
Y
E
A
LREGYRR
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
-------
P
---------
G
W
D
---------
A
F
R
L
-----
V
E
------------
E
A
R
V
A
L
I
P
A
S
A
F
Y
----
L
--
E
D
--
P
--
P
K
------
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
83
HHSearch
66.07
31%
-117
- C1 -
1GD9
2
?
A:
[26-381]
------------------------
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
-
T
-
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
R
S
-----
W
------
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
--------------
L
T
---------
S
K
K
F
-----
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
----
K
--
A
-------
G
E
-----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
-
25
PsiBlast_CBE
65.93
33%
-114
- C1 -
3E2Z
5
KAT3_MOUSE
A:
[4-404]
----
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
D
-
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
-
D
---
N
M
---
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
-
P
-
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
--
V
P
V
F
I
P
L
RSKPTDGMKW-
T
S
S
----------
D
---------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
E
-
R
-
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
I
K
R
M
D
-------
D
-------
P
------
E
C
Y
F
N
-------
S
L
P
----------
K
E
L
E
V
-------
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
---
A
---------
D
L
S
---------
D
M
N
S
-----
D
E
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
----
D
SK
S
K
--
P
--
H
F
E
-----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
-----
40
PsiBlast_CBE
65.17
35%
-111
- C1 -
1B5P
3
AAT_THET8
A:
[34-381]
---------------------------
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
-
L
A
-
Q
---
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
-
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
------------
T
L
P
----------
E
EG-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
----
E
H
F
S
P
G
R
V
A
P
-
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
------
T
N
-------
Q
-------
E
A
S
R
A
F
V
E
-
M
A
R
-------
E
A
-------------
Y
R
R
-------
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
---
P
-----------
D
---------
E
V
R
A
-----
A
E
--------
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
---------------
A
F
-----
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
44
PsiBlast_CBE
64.90
35%
-112
- C1 -
5BJ4
3
AAT_THET8
A:
[34-381]
---------------------------
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
-
L
A
-
Q
---
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
-
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
------------
T
L
P
----------
E
EG-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
----
E
H
F
S
P
G
R
V
A
P
-
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
------
T
N
-------
Q
-------
E
A
S
R
A
F
V
E
-
M
A
R
-------
E
A
-------------
Y
R
R
-------
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
---
P
-----------
D
---------
E
V
R
A
-----
A
E
--------
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
---------------
A
F
-----
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
42
PsiBlast_CBE
64.68
35%
-111
- C1 -
1B5O
3
AAT_THET8
A:
[34-381]
---------------------------
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
-
L
A
-
Q
---
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
-
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
------------
T
L
P
----------
E
EG-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
----
E
H
F
S
P
G
R
V
A
P
-
E
H
T
L
T
V
N
G
A
A
K
A
F
A
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T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
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V
S
S
Q
S
T
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P
D
T
I
A
Q
W
A
T
L
E
A
L
------
T
N
-------
Q
-------
E
A
S
R
A
F
V
E
-
M
A
R
-------
E
A
-------------
Y
R
R
-------
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
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G
A
F
Y
V
L
M
D
T
S
P
I
A
---
P
-----------
D
---------
E
V
R
A
-----
A
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--------
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
---------------
A
F
-----
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
90
HHSearch
64.05
35%
-105
* C1 *
1B5P
3
AAT_THET8
A:
[24-380]
-----------------
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
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V
K
E
A
A
R
R
A
-
L
A
-
Q
---
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
-
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
--
V
V
V
E
V
E
T
-----------
L
P
E
----------
E
G--------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
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A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
-
R
--
V
A
P
E
-
H
-
T
L
T
V
N
G
A
A
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A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
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V
I
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A
M
A
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V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
------
T
N
-------
Q
E
A
S
----
R
------
A
-
F
V
E
-------
M
A
R
----------
E
A
Y
R
R
-------
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
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Y
V
L
M
D
T
S
P
I
A
--------------
P
D
---------
E
V
R
A
-----
A
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--------
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
----
A
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F
-----
G
H
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R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
-
91
HHSearch
63.48
31%
-110
- C1 -
1O4S
8
AAT_THEMA
A:
[41-384]
------------------------
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
-
L
Q
-
K
---
G
E
---
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
-
P
-
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
--
T
V
N
V
V
E
T
-----------
F
M
S
----------
K
N--------
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
-
F
T
S
I
L
D
V
S
E
G
F
D
-
R
-
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
------
E
V
-------
D
-----------------
N
S
-------
Y
M
V
----------
Q
T
F
K
E
-------
R
K
N
F
V
V
E
R
L
K
K
M
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
D
--------------------------
D
V
K
F
-----
C
E
--------
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
----
K
-----------
P
-----
G
F
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R
L
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F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
-
67
PsiBlast_CBE
63.31
31%
-112
- C1 -
1GDE
4
?
B:
[29-379]
---------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
-------
R
SW----
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
-------
I
F
---
P
---------
R
I
R
---------
D
T
G
L
TSKKF
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-----
G
--
K
A
--
G
--
E
G
-------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
---
68
PsiBlast_CBE
62.29
31%
-113
- C1 -
1GDE
4
?
A:
[29-379]
---------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
-------
R
S
W
----
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
-------
I
F
---
P
---------
R
I
R
---------
D
T
G
L
T
S
K
K
F
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-----
G
--
K
A
--
G
--
E
G
-------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
---
70
PsiBlast_CBE
61.92
31%
-115
- C1 -
1GD9
2
?
A:
[29-379]
---------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
-------
R
S
W
----
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
-------
I
F
---
P
---------
R
I
R
---------
D
T
G
L
T
S
K
K
F
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-----
G
--
K
A
--
G
--
E
G
-------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
---
65
PsiBlast_CBE
61.84
31%
-111
- C1 -
1DJU
2
?
B:
[28-378]
---------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
-------
R
S
W
----
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
-------
I
F
---
P
---------
R
I
R
---------
D
T
G
L
T
S
K
K
F
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-----
G
--
K
A
--
G
--
E
G
-------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
---
66
PsiBlast_CBE
61.73
31%
-115
- C1 -
1DJU
2
?
A:
[28-378]
---------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
-------
R
S
W
----
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
-------
I
F
---
P
---------
R
I
R
---------
D
T
G
L
T
S
K
K
F
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-----
G
--
K
A
--
G
--
E
G
-------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
---
69
PsiBlast_CBE
61.07
31%
-113
- C1 -
1GD9
2
?
B:
[29-379]
---------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
-
L
D
-
K
---
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
--
K
P
V
E
V
P
T
-----------
Y
E
E
----------
D
E--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
E
-
R
-
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
------
K
D
-------
E
-------
R
SW----
K
-
A
V
E
-------
E
M
R
----------
K
E
Y
D
R
-------
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
-------
I
F
---
P
---------
R
I
R
---------
D
T
G
L
TSKKF
S
E
--------
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-----
G
--
K
A
--
G
--
E
G
-------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
---