@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4696: (2016-02-29 )
MELLSGAEMVVRSLRDEGVKYIYGYPGGALLHIYDALFKEHDVTHILVRHEQAATHMADGYARATGKPGVVLVTSGPGATNAITGIATAYMDSIPMVILSGQVPSNMVGTDAFQETDMVGISRPIVKHSFIIKHPSEIPEVIKKAFYLAQSGRPGPVVVDIPKDMGDPTQKFEYSYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPVVYSGGGVIMGNAAAPLTELAQMLNLPVTNTLMGLGGYPGADRQFLGMLGMHGSFTANLAMHHSDVILAVGARFDDRVINGAAKFCPNAKIIHIDIDPASISKTIKADIPIVGPVDSVLTEMVAIVREIGETPNQDAQAAWWKQIDEWRGNRGLFPYDKGDGSIIKPQTVIETLYEVTHGDAFITSDVGQHQMFASQYYKFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDDDVACVTGEGSIQMNIQELSTCLQYDLPVKIVNLNNGALGMVRQWQDMQYNSRYSHSYMESLPDFVKLAEAYGHVGMRITDLKDLKPKMEEAFAMKNRLVFLDIQVDASEHVYPMQIRDGAMRDMWLSKTERT
Atome Classification :
(20 SA)
.........10........20........30........40....-....50........60....-....70........80........90........100.......110.......120.......130.......140.......150.......160.......170--.......180...---....190...-------....200.......210.......-220...--....230.......240.......----250--.......260-...-....270.......280.......290....---------...300.......310.......320.......330.......340.......350----.......360....---...370.......380....---...---390.......400.......410.......420.......430.......440.......450.......460.......470.......480.....---..490..--------...--..500..------.....510.......520.......530....---...540.......550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELL
S
G
A
E
M
V
V
R
S
L
R
DEG
V
K
Y
I
YGYPG
G
A
L
L
H
I
Y
D
A
L
F
K
EHD
V
T
H
-
I
L
V
R
H
E
Q
A
A
T
H
M
ADGYARAT-GKP
G
V
V
L
V
TSGPGA
T
N
A
I
T
G
I
A
T
A
Y
M
DSI
P
M
V
I
LSGQVPSNMVGTDAFQETDMVGISRP
I
V
K
H
S
FIIK
H
P
S
E
I
P
E
V
I
K
K
A
F
Y
L
AQSGRPG
P
V
V
V
DIPKDMGDPTQKF--EYSYP
K
K
V
K
LRSY---SPAVRGHS
G
Q
-------
I
R
K
A
A
E
M
L
L
AAKR
P
V
V
YSGG
G
V
I
M-GNAAA
P
--
L
T
E
L
A
Q
M
LNLPV
T
N
T
L
MGLGGYPG----A
D
R
--
Q
F
L
G
M
LGMHG-S
F
T
-
A
N
L
A
M
HHS
D
V
I
L
A
VGARFD
D
R
V
IN
G
A
A
KFCP---------N
A
K
I
I
H
I
DI
D
P
A
S
I
S
K
T
IKADIPIVG
P
V
D
S
V
L
T
E
M
V
A
I
V
R
E
IGETPN
Q
D
A
Q
A
A
W
W
K
----
Q
I
D
E
WRGNRGLFPY---DKGDGSII
K
P
Q
T
V
I
E
T
L
Y
E
V---THG---
D
A
F
I
TSDVG
Q
H
Q
M
F
A
S
Q
Y
YKFNKPN
R
W
INSGGLGTMGFGFP
A
A
M
G
I
K
L
NFPDD
D
V
A
C
V
TGEG
S
I
Q
M
N
I
Q
E
L
S
T
C
L
QYDL
P
V
K
I
V
NLNNG
A
L
G
M
V
R
Q
W
Q
---DMQYNSR--------Y
S
H
--
S
Y
M
E
S
L
P
------
D
F
V
K
L
A
E
A
YGHVG
M
R
I
T
D
L
K
D
L
K
P
K
M
E
E
A
F
A
M---KN
R
L
V
F
L
D
I
Q
VDASE
H
V
Y
P
M
Q
IRDG
A
M
R
D
M
WLSKTERT
3
PsiBlast_PDB
97.82
42%
-98
- C5 -
1T9A
9
ILVB_YEAST
A:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
----------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
6
PsiBlast_PDB
97.70
42%
-100
- C5 -
1T9D
9
ILVB_YEAST
A:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
----------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
1
PsiBlast_PDB
97.34
42%
-104
- C5 -
1JSC
8
ILVB_YEAST
A:
[35-591]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
S
------------
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
A
Y
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
---------------------------
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
------------------------
25
PsiBlast_CBE
97.17
42%
-99
- C5 -
1T9B
9
ILVB_YEAST
B:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
S
-----------
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
29
HHSearch
97.08
42%
-98
- C5 -
1T9B
9
ILVB_YEAST
A:
[80-660]
-
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
--
P
I
P
------------------
F
V
M
Q
S
-------
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
A
D
G
P
R
L
--
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
Y
P
Y
A
Y
M
---
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
---
A
N
D
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
-
L
N
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
E
--
5
PsiBlast_PDB
97.08
42%
-99
- C5 -
1T9C
7
ILVB_YEAST
A:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
S
----------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
24
PsiBlast_CBE
96.90
42%
-101
- C5 -
1T9C
7
ILVB_YEAST
B:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
--------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
21
PsiBlast_CBE
96.88
42%
-97
- C5 -
1T9D
10
ILVB_YEAST
D:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
S
----------
S
R
A
Q
DEFVMQS
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
RL
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
EARRAAAEG
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
AND
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
23
PsiBlast_CBE
96.64
42%
-101
- C5 -
1T9D
9
ILVB_YEAST
B:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
---------------------F
V
M
Q
S
--
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
27
PsiBlast_CBE
96.54
42%
-99
- C5 -
1N0H
9
ILVB_YEAST
B:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
S
----------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
26
PsiBlast_CBE
96.51
42%
-98
- C5 -
1T9A
9
ILVB_YEAST
B:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
--------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
2
PsiBlast_PDB
96.39
42%
-98
- C5 -
1N0H
9
ILVB_YEAST
A:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
T
T
L
P
S
---------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
4
PsiBlast_PDB
96.21
42%
-101
- C5 -
1T9B
9
ILVB_YEAST
A:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
---------------------F
V
M
Q
S
--
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
22
PsiBlast_CBE
96.08
42%
-98
- C5 -
1T9D
9
ILVB_YEAST
C:
[82-644]
---
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
-
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
--
T
A
A
I
L
--
R
N
P
I
P
T
K
---------------------------
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
-
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
----
E
D
P
--
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
E
------
R
S
E
W
F
A
----
Q
I
N
K
W
K
K
E
---
Y
P
Y
AYM
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
---
S
L
F
Y
E
H
R
--------
Y
S
H
--
T
H
Q
L
N
-
P
------
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
---
K
G
P
-
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
------------------
31
HHSearch
87.93
32%
-90
* C5 *
2PAN
5
GCL_ECOLI
A:
[25-584]
-
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
K
H
G
G
I
R
H
-
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
--
D
P
D
M
Y
E
P
L
--
P
V
Y
-----
K
P
A
A
S
R
M
Q
-------
I
E
K
A
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
I
N
-
A
D
A
A
A
L
--
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
----
D
H
E
--
L
M
A
G
M
V
G
L
Q
T
A
H
R
Y
-
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
G
R
L
P
C
R
K
E
W
V
A
----
D
C
Q
Q
R
K
R
T
L
L
R
-
K
T
---
H
-
F
D
N
V
P
V
K
P
Q
R
V
Y
E
E
M
N
K
A
---
F
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
---
R
A
F
D
M
D
Y
CVQLAFEN
I
N
S
SE
V
N
G
-
Y
G
V
------
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
A
K
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
I
L
E
R
V
T
N
I
---------------------
7
PsiBlast_PDB
87.47
33%
-93
- C5 -
2PAN
5
GCL_ECOLI
A:
[37-564]
-------------
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
K
H
G
G
I
R
H
-
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
--
Q
V
A
E
I
--
E
F
D
P
D
M
Y
E
P
L
P
V
Y
---
K
P
A
--
A
S
R
M
Q
-------
I
E
K
A
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
I
N
-
A
D
A
A
A
L
--
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
----
D
H
E
--
L
M
A
G
M
V
G
L
Q
T
-
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
R
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
G
R
L
P
C
R
K
E
W
V
A
----
D
C
Q
Q
R
K
--
R
T
L
L
R
K
---
T
H
F
D
N
V
P
V
K
P
Q
R
V
Y
E
E
M
N
K
A
---
F
G
R
---
D
V
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
AF
D
M
D
Y
C
V
Q
--------
L
A
F
--
E
N
I
N
S
S
E
VNGYGV
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
A
K
A
L
-----------------------------------------
33
HHSearch
81.59
26%
-93
- C5 -
3EYA
11
POXB_ECOLI
A:
[2-537]
--
K
Q
T
V
A
A
Y
I
A
K
T
L
E
S
A
G
V
K
R
I
W
G
V
T
G
D
S
L
N
G
L
S
D
S
L
N
R
M
G
T
I
E
W
-
M
S
T
R
H
E
E
V
A
A
F
A
A
G
A
E
A
Q
L
S
-
G
E
L
A
V
C
A
G
S
C
G
P
G
N
L
H
L
I
N
G
L
F
D
C
H
R
N
H
V
P
V
L
A
I
A
A
H
I
P
S
S
E
I
G
S
G
Y
F
Q
E
T
H
P
Q
E
L
F
R
E
C
S
H
Y
C
E
L
V
S
S
P
E
Q
I
P
Q
V
L
A
I
A
M
R
K
A
V
L
N
R
-
G
V
S
V
V
V
L
P
G
D
V
A
L
K
P
A
P
E
--
G
A
T
M
H
-
W
Y
--
H
A
P
---
Q
P
V
V
T
P
E
E
E
E
-------
L
R
K
L
A
Q
L
L
R
Y
S
S
N
I
A
L
M
C
G
S
G
C
A
G
---
A
H
K
E
--
L
V
E
F
A
G
K
I
K
A
P
I
V
H
A
L
R
G
K
E
H
V
E
Y
----
D
N
P
--
Y
D
V
G
M
T
G
L
I
G
-
F
S
S
-
G
F
H
T
M
M
N
A
D
T
L
V
L
L
G
T
Q
F
P
Y
R
A
F
-----
Y
P
T
---------
D
A
K
I
I
Q
I
D
I
N
P
A
S
I
G
A
H
S
K
V
D
M
A
L
V
G
D
I
K
S
T
L
R
A
L
L
P
L
V
E
E
K
A
D
---
R
K
F
L
D
K
A
L
E
----
D
Y
R
D
A
R
K
G
L
D
D
--
L
---
A
K
P
S
E
K
A
I
H
P
Q
Y
L
A
Q
Q
I
S
H
F
---
A
A
D
---
D
A
I
F
T
C
D
V
G
T
P
T
V
W
A
A
R
Y
L
K
M
N
G
K
R
R
L
L
G
S
F
N
H
G
S
M
A
N
A
M
P
Q
A
L
G
A
Q
A
T
E
P
E
R
Q
V
V
A
M
C
G
D
G
G
F
S
M
L
M
G
D
F
L
S
V
V
Q
M
K
L
P
V
K
I
V
V
F
N
N
S
V
L
G
F
V
------------------------
G
--
T
E
L
-
H
D
T
------
N
F
A
R
I
A
E
A
C
G
I
T
G
I
R
V
E
K
A
S
E
V
D
E
A
L
Q
R
A
F
S
----
I
D
G
P
V
L
V
D
V
V
V
A
K
E
E
L
A
I
P
P
Q
-----------------
14
PsiBlast_PDB
80.80
30%
-86
- C5 -
2EZ8
4
POXB_LACPL
A:
[11-532]
--
I
L
A
G
A
-
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
-
G
V
A
V
V
Q
I
P
V
D
L
--
P
W
Q
Q
I
PA
E
D
W
Y
A
S
A
N
S
Y
Q
T
P
L
L
P
E
P
D
V
Q
A
-----------
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
---
R
K
A
G
K
E
--
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
------
Y
P
A
KGIV
A
D
R
YP
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
--
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
-------
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
----
D
K
Q
E
G
P
L
Q
A
Y
Q
-
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
W
I
K
D
E
Q
---
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
N
D
I
-------
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
-----------------------------------------
18
PsiBlast_PDB
80.65
30%
-86
- C5 -
1POX
5
POXB_LACPL
A:
[3-524]
--
I
L
A
G
A
-
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
-
G
V
A
V
V
Q
I
P
V
D
L
--
P
W
Q
Q
I
--
S
A
E
D
W
Y
A
S
A
N
N
Y
Q
---
T
P
L
L
P
E
P
D
V
Q
A
------
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
---
R
K
A
G
K
E
--
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
------
Y
P
A
KGIV
A
D
R
YP
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
--
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
K
T
D
I
A
V
L
A
D
A
Q
K
T
L
A
A
I
L
A
Q
V
S
E
R
E
S
T
P
-------
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
----
D
K
Q
E
G
P
L
Q
A
Y
Q
-
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
V
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
---
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
N
D
I
-------
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
-----------------------------------------
10
PsiBlast_PDB
80.51
30%
-86
- C5 -
4FEG
9
?
A:
[11-532]
--
I
L
A
G
A
-
A
V
I
K
V
L
E
A
W
G
V
D
H
L
Y
G
I
P
G
G
S
I
N
S
I
M
D
A
L
S
A
E
R
D
R
I
H
Y
I
Q
V
R
H
E
E
V
G
A
M
A
A
A
A
D
A
K
L
T
-
G
K
I
G
V
C
F
G
S
A
G
P
G
G
T
H
L
M
N
G
L
Y
D
A
R
E
D
H
V
P
V
L
A
L
I
G
Q
F
G
T
T
G
M
N
M
D
T
F
Q
E
M
N
E
N
P
I
Y
A
D
V
A
D
Y
N
V
T
A
V
N
A
A
T
L
P
H
V
I
D
E
A
I
R
R
A
Y
A
H
Q
-
G
V
A
V
V
Q
I
P
V
D
L
--
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W
Q
Q
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PA
E
D
W
Y
A
S
A
N
S
Y
Q
T
P
L
L
P
E
P
D
V
Q
A
-----------
V
T
R
L
T
Q
T
L
L
A
A
E
R
P
L
I
Y
Y
G
I
G
A
---
R
K
A
G
K
E
--
L
E
Q
L
S
K
T
L
K
I
P
L
M
S
T
------
Y
P
A
KGIV
A
D
R
YP
A
Y
L
G
S
A
N
R
V
A
-
Q
K
P
-
A
N
E
A
L
A
Q
A
D
V
V
L
F
V
G
N
N
Y
P
F
A
E
V
S
K
A
--
F
K
N
---------
T
R
Y
F
L
Q
I
D
I
D
P
A
K
L
G
K
R
H
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T
D
I
A
V
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A
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A
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T
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A
A
I
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A
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V
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E
R
E
S
T
P
-------
W
W
Q
A
N
L
A
N
V
K
N
W
R
A
Y
L
A
S
L
E
----
D
K
Q
E
G
P
L
Q
A
Y
Q
-
V
L
R
A
V
N
K
I
---
A
E
P
---
D
A
I
Y
S
I
D
V
G
D
I
N
L
N
A
N
R
H
L
K
L
T
P
S
N
R
H
I
T
S
N
L
F
A
T
M
G
V
G
I
P
G
A
I
A
A
K
L
N
Y
P
E
R
Q
V
F
N
L
A
G
D
G
G
A
S
M
T
M
Q
D
L
A
T
Q
V
Q
Y
H
L
P
V
I
N
V
V
F
T
N
C
Q
Y
G
F
I
K
D
E
Q
---
E
D
T
N
Q
N
D
--------
F
I
G
--
V
E
F
N
D
I
-------
D
F
S
K
I
A
D
G
V
H
M
Q
A
F
R
V
N
K
I
E
Q
L
P
D
V
F
E
Q
A
K
A
I
-----------------------------------------