@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5098: (2016-03-04 )
MSLHLKPGQLTLADLRQAYLAPVRLSLDPSADAPIAASVACVENIIAEGRTAYGINTGFGLLASTRISPADLEKLQRSIVLSHAAGVGEALDDAMVRLVMLLKVNSLARGFSGIRRKVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLIGESRARHRGEWLPAAEALAVAGLEPLTLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARIHAARGQRGQIDVAAAYRDLLTASSEVARSHEKCDKVQDPYSLRCQPQVMGACLTQMRQAAEVLEIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNLALALAEIGSLSERRISLMMDMHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWAMAENVRGILAVEWLGACQGLDFREGLKSSPKLEQARRLLRDKVPYYQEDRFFAPDIEAASQLLASGCLNALLPARLLPSL
Atome Classification :
(23 SA)
.........-10........20.---......--.30.--.......40........50........60.---.......70........80.......-.90........100.......110.......120.......130.......140.......150.......160-..---.-..-..--..170.......180.......190.......200.......210.......220.......230.......240........250.......260.--.----------....---.270-----------.---------------...---------..-------...280.......290.......300.......310.......320..--......330.......340.......350.....-..360...-.-...370.--.--..--....380.......390.......400........410.--......420.......430.......440.......450---..---.---------..---------..460.........470---.--....--.---------..480.....-..490.......500.......--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLHLKPG
Q
-
L
T
L
A
D
L
R
Q
A
Y
LA
P
---
V
R
L
SLD--PSAD--A
P
I
A
A
S
V
A
C
V
E
N
I
I
AEG
R
T
A
Y
GINTG
F
G
L
L
---
A
STRI
S
P
A
D
L
E
K
L
Q
R
S
I
V
L
S
HAAGV
G
-
E
A
L
D
D
A
M
V
R
L
V
M
L
L
K
V
N
S
L
A
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
INAE
V
Y
PHIPLKGSVGASGD
L
A
P
L
A
H
M
S
L
V
L
I
GES---RA---R-HR-GE--WL
P
A
A
E
A
L
A
VAGLE
P
L
T
L
A
A
KE
G
L
A
L
LNGTQ
V
S
T
A
Y
A
L
R
G
L
F
E
A
E
D
L
F
A
A
A
T
V
CGGL
S
V
E
A
M
LGSRAPF
D
A
R
I
H-AARGQRG
Q
I
D
V
A
A
A
Y
R
D
L
L
T
A
S
--
S
----------
E
V
A
R
---
S
H
-------------
E
---------------
K
C
D
---------KV-------QDPYSLRC
Q
P
Q
V
M
G
A
C
L
T
Q
M
R
Q
A
A
E
V
L
E
I
E
ANAVSDN
P
L
V
F
A
AE-G
D
V
--ISGGNFHA
E
P
V
A
M
A
A
D
N
L
A
L
A
L
A
E
IG
S
L
S
E
R
R
I
S
-
L
M
M
D
M
H
M
S
-Q-LP
P
F
L
-
V
--A--NG--GVNS
G
F
M
I
A
Q
V
T
A
A
A
LASDNKALAHP-ASVDSLPTSANQ--ED
H
V
SMAPNAG
K
R
L
W
A
M
A
E
NV
R
G
I
L
A
V
E
W
L
G
ACQGL
D
F
R
---
E
G---L---------KS---------SP
K
--
L
E
Q
A
R
R
L
L
R
DK----V--PYYQ--E---------DRFFAP
D
I
E
A
-
A
S
Q
L
L
A
S
G
C
L
N
A
L
L
P
A
R
LLPSL--------
1
PsiBlast_PDB
99.47
81%
-100
- C8 -
1GK3
2
HUTH_PSEPU
A:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
A
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
4
PsiBlast_PDB
98.88
81%
-102
- C8 -
1B8F
2
HUTH_PSEPU
A:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
6
PsiBlast_PDB
98.87
81%
-102
- C8 -
1EB4
2
HUTH_PSEPU
A:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
A
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
22
PsiBlast_CBE
98.59
81%
-98
- C8 -
1GK2
3
HUTH_PSEPU
C:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
5
PsiBlast_PDB
98.57
81%
-102
- C8 -
1GKJ
2
HUTH_PSEPU
A:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
F
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
23
PsiBlast_CBE
98.30
81%
-99
- C8 -
1GK2
3
HUTH_PSEPU
B:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
21
PsiBlast_CBE
98.24
81%
-98
- C8 -
1GK2
3
HUTH_PSEPU
D:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
2
PsiBlast_PDB
98.23
81%
-100
- C8 -
1GK2
3
HUTH_PSEPU
A:
[3-509]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
3
PsiBlast_PDB
77.76
81%
-32
- C8 -
1GKM
4
HUTH_PSEPU
A:
[3-507]
--
L
T
L
K
P
G
T
-
L
T
L
A
Q
L
R
A
I
H
A
A
P
---
V
R
L
Q
L
D
--
A
S
A
A
--
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
---
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
-
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
M
D
-
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
---
K
A
---
R
-
Y
K
-
G
Q
--
W
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
-
E
A
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
--
S
----------
E
V
S
L
---
S
H
-------------
K
---------------
N
A
D
---------
K
V
-------
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
A
E
-
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
-
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
--
E
--
N
G
--
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
-
H
S
V
D
S
L
P
T
S
A
N
Q
--
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
G
---
L
---------
K
T
---------
S
A
K
--
L
E
K
A
R
Q
A
L
R
S
E
----
V
--
A
H
Y
D
--
R
---------
D
R
F
F
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
--------
49
HHSearch
77.64
36%
-85
- C8 -
2O6Y
-
TALY_RHOS4
A:
[11-522]
--
V
E
L
D
-
R
H
-
I
D
L
D
Q
A
H
A
V
A
S
G
G
---
A
R
I
V
L
A
--
P
P
A
R
--
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
---
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
-
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
---
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
---
D
F
---
L
D
R
D
-
G
T
--
R
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
-
D
L
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
-
G
--
S
----------
A
R
V
V
---
R
H
VIAE
R
R
L
D
AGDIG
T
---------------
E
P
E
---------
A
G
-------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
V
F
P
P
D
G
S
V
P
A
--
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
-
R
L
T
D
E
R
L
N
R
G
-
L
P
P
F
L
-
H
--
R
G-
P
A
--
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
-
T
G
P
-
A
S
I
H
S
I
S
T
N
A
A
N
--
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
---
C
G
SGL
D
---------
G
V
---------
S
P
A
--
G
K
K
L
V
Q
A
L
R
E
Q
----
F
--
P
P
L
E
--
T
---------
D
R
P
L
G
Q
E
I
A
A
-
L
A
T
H
L
L
Q
Q
S
P
--------------------
14
PsiBlast_PDB
77.43
37%
-83
- C8 -
2O6Y
-
TALY_RHOS4
A:
[18-518]
--------------
D
L
D
Q
A
H
A
V
A
S
GG
A
R
I
V
L
A
--
P
P
A
R
--
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
---
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
-
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
---
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
---
D
F
---
L
-
D
R
D
G
T
--
R
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
-
D
L
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
--
A
----------
R
V
V
R
HVI
A
E
-------------
R
---------------
R
L
D
AGDIGTEPE
A
G
-------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
P
D
-
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
-
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
--
G
--
P
A
--
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
-
A
S
I
H
S
I
S
T
N
A
A
N
--
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
G
---
L
---------
D
G
V--------
S
P
A
--
G
K
K
L
V
Q
A
L
R
E
Q
----
F
--
P
P
L
E
--
T
---------
D
R
P
L
G
Q
E
I
A
A
L
A
T
H
L
L
-------------------------
11
PsiBlast_PDB
75.65
35%
-83
- C8 -
2OHY
-
TAM_STRGL
A:
[20-524]
----------
L
T
V
E
A
V
R
R
--
V
A
E
---
E
R
A
T
V
D
--
V
P
A
E
S
I
A
K
A
Q
K
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
E
M
---
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
-
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
---
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
---
Y
V
---
L
-
R
D
-
G
R
--
P
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
--
G
LTVE
H
A
D
L
R
R
E
L
Q
K
---
D
K
-------------
E
---------------
A
G
K
---------
D
V
Q
R
S
EIYL
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
E
G
K
--
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
-
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
--
S
G-
D
P
--
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
-
A
S
T
Q
S
V
P
S
N
G
D
N
--
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
G
---
L
---------
S
P
---------
A
A
K
A
T
Y
E
A
V
R
R
L
--------
V
--
P
T
L
G
--
V
---------
D
R
Y
M
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
----------------------
48
HHSearch
75.37
29%
-87
- C8 -
2NYN
-
PAL_ANAVT
A:
[25-563]
-
N
V
I
I
G
N
Q
K
-
L
T
I
N
D
V
A
R
V
A
R
N
G
---
T
L
V
S
L
T
NN
T
D
I
L
--
Q
G
I
Q
A
S
C
D
Y
I
N
N
A
V
E
S
G
--------------------
I
S
R
E
Q
A
S
E
L
Q
T
N
L
V
W
F
L
K
T
G
A
G
-
N
K
L
P
L
A
D
V
R
A
A
M
L
L
R
A
N
S
H
M
R
G
A
S
G
I
R
L
E
L
I
K
R
M
E
I
F
L
N
A
G
V
T
P
Y
V
Y
E
F
G
S
I
G
---
D
L
V
P
L
S
Y
I
T
G
S
L
I
G
L
D
PS
F
K
V
---
D
-
F
N
-
G
K
--
E
M
D
A
P
T
A
L
R
Q
L
N
L
S
P
L
T
L
L
P
K
E
G
L
A
M
M
N
G
T
S
V
M
T
G
I
A
A
N
C
V
Y
D
T
Q
I
L
T
A
I
A
M
G
V
H
A
L
D
I
Q
A
L
N
G
T
N
Q
S
F
H
P
F
I
H
-
N
S
K
P
H
P
G
Q
L
W
A
A
D
Q
M
I
S
L
L
A
-
N
--
S
----------
Q
L
V
R
---
D
E
LDGK--------------------------------------
I
-------
Q
D
R
Y
S
L
R
C
L
P
Q
Y
L
G
P
I
V
D
G
I
S
Q
I
A
K
Q
I
E
I
E
I
N
S
V
T
D
N
P
L
I
D
V
D
N
-
Q
A
S
--
Y
H
G
G
N
F
L
G
Q
Y
V
G
M
G
M
D
H
L
R
Y
Y
I
G
L
L
A
K
H
L
D
V
Q
I
A
-
L
L
A
S
P
E
F
S
N
G
-
L
P
P
S
L
-
L
--
G
NR
E
R
--
K
V
N
M
G
L
K
G
L
Q
I
C
G
N
S
I
M
P
L
L
T
F
Y
G
N
S
I
A
D
R
F
P
T
H
A
E
Q
F
N
--
Q
N
I
N
S
Q
G
Y
T
S
A
T
L
A
R
R
S
V
D
I
F
Q
N
Y
V
A
I
A
L
M
F
G
V
Q
A
V
D
L
R
---
T
Y
---
K
K
TGHYDARA
C
L
---------
S
P
A
--
T
E
R
L
Y
S
A
V
R
H
-----
V
--
V
G
Q
K
P
T
S
DRPYIWNDN
E
Q
G
L
D
E
H
I
A
R
-
I
S
A
D
I
A
A
G
G
V
I
V
Q
A
V
Q
D
I
L
-----------
8
PsiBlast_PDB
75.29
35%
-84
- C8 -
3KDY
-
TAM_STRGL
A:
[20-524]
----------
L
T
V
E
A
V
R
R
--
V
A
E
---
E
R
A
T
V
D
--
V
P
A
E
S
I
A
K
A
Q
K
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
A
M
---
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
-
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
---
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
---
Y
V
---
L
-
R
D
-
G
R
--
P
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
--
G
LTVE
H
A
D
L
R
R
E
L
Q
K
---
D
K
-------------
E
---------------
A
G
K
---------
D
V
Q
R
S
EIYL
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
E
G
K
--
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
-
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
--
S
G-
D
P
--
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
-
A
S
T
Q
S
V
P
S
N
G
D
N
--
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
G
---
L
---------
S
P
---------
A
A
K
A
T
Y
E
A
V
R
R
L
--------
V
--
P
T
L
G
--
V
---------
D
R
Y
M
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
----------------------
56
Fugue
70.90
27%
-92
* C8 *
2NYF
-
PAL_NOSP7
A:
[24-566]
S
I
V
T
V
G
D
R
N
-
L
T
I
D
E
V
V
N
V
A
R
H
G
---
T
Q
V
R
L
T
--
D
N
--------------------
A
D
V
I
R
G
V
Q
A
S
C
D
Y
I
N
N
A
V
E
T
A
I
S
R
E
Q
A
A
E
L
Q
T
N
L
I
W
F
L
K
S
G
A
G
-
N
K
L
S
L
A
D
V
R
A
A
M
L
L
R
A
N
S
H
L
Y
G
A
S
G
I
R
L
E
L
I
Q
R
I
E
T
F
L
N
A
G
V
T
P
H
V
Y
E
F
G
S
I
G
---
D
L
V
P
L
S
Y
I
T
G
A
L
I
G
L
D
---
P
S
FTV
D
-
F
D
-
G
K
--
E
M
D
A
V
T
A
L
S
R
L
G
L
P
K
L
Q
L
Q
P
K
E
G
L
A
M
M
N
G
T
S
V
M
T
G
I
A
A
N
C
V
Y
D
A
K
V
L
L
A
L
T
M
G
V
H
A
L
A
I
Q
G
L
Y
G
T
N
Q
S
F
H
P
F
I
H
-
Q
C
K
P
H
P
G
Q
L
W
T
A
D
Q
M
F
S
L
L
K
D
S
--
S
----------
L
V
R
E
-----------------------------------------------
E
-------
Q
D
R
Y
S
L
R
C
L
A
Q
F
I
G
P
I
V
D
G
V
S
E
I
T
K
Q
I
E
V
E
M
N
S
V
T
D
N
P
L
I
D
V
E
N
-
Q
V
S
--
Y
H
G
G
N
F
L
G
Q
Y
V
G
V
T
M
D
R
L
R
Y
Y
I
G
L
L
A
K
H
I
D
V
Q
I
A
-
L
L
V
S
P
E
F
S
-
N
G
L
P
P
S
L
-
V
--
G
--
N
S
DR
K
V
N
M
G
L
K
G
L
Q
I
S
G
N
S
I
M
P
L
L
S
F
Y
G
N
S
--
L
A
D
R
F
P
T
H
A
E
Q
FN
Q
N
I
N
S
Q
G
Y
I
S
A
N
L
T
R
R
S
V
D
I
F
Q
N
Y
M
A
I
A
L
M
F
G
V
Q
A
V
D
L
R
---
T
Y
---
K
---------
M
K
GHYDARTCL
S
P
N
--
T
V
Q
L
Y
T
A
V
C
E
V
----
V
GK
P
L
T
S
--
V
---------
R
P
Y
I
W
N
D
N
E
Q
-
C
L
D
E
H
I
A
R
I
S
A
D
I
A
G
G
G
L
I
V
Q
A
V
E
H
I
F
S
S
L
20
PsiBlast_PDB
69.21
31%
-82
- C8 -
4C6G
-
PAM_TAXWC
A:
[80-536]
----------------------------------------
A
R
V
E
T
C
S
S
W
V
Q
R
K
A
E
D
G
A
D
I
Y
G
-----------------------
L
Q
E
S
L
I
R
C
L
L
A
G
V
F
T
D
E
L
P
A
T
A
T
R
S
A
M
L
L
R
L
N
S
F
T
Y
G
C
S
G
I
R
W
E
V
M
E
A
L
E
K
L
L
N
S
N
V
S
P
K
V
P
L
R
G
S
V
S
A
S
G
D
L
I
P
L
A
Y
I
A
G
L
L
I
G
K
P
---
S
V
---
I
-
A
R
I
G
D
D
V
E
V
P
A
P
E
A
L
S
R
V
G
L
R
P
F
K
L
Q
A
K
E
G
L
A
L
V
A
G
T
S
F
A
T
A
V
A
S
T
V
M
Y
D
A
N
V
L
L
L
L
V
E
T
L
C
G
M
F
C
E
V
I
F
G
R
E
E
F
A
H
P
L
I
H
-
K
V
K
P
H
P
G
Q
I
E
S
A
E
L
L
E
W
L
L
R
S
S
P
F
Q
----------
E
L
S
R
---
E
Y
-------------
Y
---------------
S
I
D
---------
K
L
KKPK---
Q
D
R
Y
A
L
R
S
S
P
Q
W
L
A
P
L
V
Q
T
I
R
D
A
T
T
T
V
E
T
E
V
N
S
A
N
D
N
P
I
I
D
H
A
N
-
D
R
A
--
L
H
G
A
N
F
Q
G
S
A
V
G
F
Y
M
D
Y
V
R
I
A
V
A
G
L
G
K
L
L
F
A
Q
F
T
E
L
M
I
E
Y
Y
S
N
-
G
-
L
P
G
N
L
-
S
LG
P
--
D
L
--
S
V
D
Y
G
L
K
G
L
D
I
A
M
A
A
Y
S
S
E
L
Q
Y
L
A
N
P
-
V
T
T
H
V
H
S
A
E
Q
H
N
--
Q
D
I
N
S
L
A
L
I
S
A
R
K
T
E
E
A
L
D
I
L
K
L
M
I
A
S
H
L
T
A
M
C
Q
A
V
D
L
R
---
Q
---------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.13
32%
-46
- C8 -
3UNV
10
?
A:
[26-530]
-
S
F
H
I
S
S
G
K
D
I
S
L
E
E
I
A
R
A
A
R
D
H
---
Q
P
V
T
L
H
--
D
E
V
V
--
N
R
V
T
R
S
R
S
I
L
E
S
M
V
S
D
E
R
V
I
Y
G
V
N
T
S
M
G
G
F
---
V
N
Y
I
V
P
I
A
K
A
S
E
L
Q
N
N
L
I
N
A
V
A
T
N
V
G
-
K
Y
F
D
D
T
T
V
R
A
T
M
L
A
R
I
V
S
L
S
R
G
N
S
A
I
S
I
V
N
F
K
K
L
I
E
I
Y
N
Q
G
I
V
P
C
I
P
E
K
G
S
L
G
K
W
S
D
L
G
P
L
A
A
I
A
L
V
C
T
G
Q
W
---
K
A
---
R
-
Y
Q
-
G
E
--
Q
M
S
G
A
M
A
L
E
K
A
G
I
S
P
M
E
L
S
F
K
E
G
L
A
L
I
N
G
T
S
A
M
V
G
L
G
V
L
L
Y
D
E
V
K
R
L
F
D
T
Y
L
T
V
T
S
L
S
I
E
G
L
H
G
K
T
K
P
F
E
P
A
V
H
-
R
M
K
P
H
Q
G
Q
L
E
V
A
T
T
I
W
E
T
L
A
D
S
--
S
----------
L
A
V
N
---
E
H
-------------
E
V
E
K
L
I
AEEMDGLVKA
S
N
H
---------
Q
I
-------
E
D
A
Y
S
I
R
C
T
P
Q
I
L
G
P
V
A
D
T
L
K
N
I
K
Q
T
L
T
N
E
L
N
S
S
N
D
N
P
L
I
D
Q
T
T
-
E
E
V
--
F
H
N
G
H
F
H
G
Q
Y
V
S
M
A
M
D
H
L
N
I
A
L
V
T
M
M
N
L
A
N
R
R
I
D
-
R
F
M
D
K
S
N
S
-
N
G
L
P
P
F
L
-
C
--
A
E-
N
A
--
G
L
R
L
G
L
M
G
G
Q
F
M
T
A
S
I
T
A
E
S
R
A
S
C
M
P
-
M
S
I
Q
S
L
S
T
T
G
D
F
--
Q
D
I
V
S
F
G
L
V
A
A
R
R
V
R
E
Q
L
K
N
L
K
Y
V
F
S
F
E
L
L
C
A
C
Q
A
V
D
I
R
-------------------
G
---------
T
A
G
--
L
S
K
R
T
R
A
L
Y
D
K
T
RTL
V
--
P
Y
L
E
--
E
---------
D
K
T
I
S
D
Y
I
E
S
-
I
A
Q
---------------------------
24
PsiBlast_CBE
65.45
32%
-46
- C8 -
3UNV
9
?
B:
[26-530]
-
S
F
H
I
S
S
G
K
D
I
S
L
E
E
I
A
R
A
A
R
D
H
---
Q
P
V
T
L
H
--
D
E
V
V
--
N
R
V
T
R
S
R
S
I
L
E
S
M
V
S
D
E
R
V
I
Y
G
V
N
T
S
M
G
G
F
---
V
N
Y
I
V
P
I
A
K
A
S
E
L
Q
N
N
L
I
N
A
V
A
T
N
V
G
-
K
Y
F
D
D
T
T
V
R
A
T
M
L
A
R
I
V
S
L
S
R
G
N
S
A
I
S
I
V
N
F
K
K
L
I
E
I
Y
N
Q
G
I
V
P
C
I
P
E
K
G
S
L
G
K
W
S
D
L
G
P
L
A
A
I
A
L
V
C
T
G
Q
W
---
K
A
---
R
-
Y
Q
-
G
E
--
Q
M
S
G
A
M
A
L
E
K
A
G
I
S
P
M
E
L
S
F
K
E
G
L
A
L
I
N
G
T
S
A
M
V
G
L
G
V
L
L
Y
D
E
V
K
R
L
F
D
T
Y
L
T
V
T
S
L
S
I
E
G
L
H
G
K
T
K
P
F
E
P
A
V
H
-
R
M
K
P
H
Q
G
Q
L
E
V
A
T
T
I
W
E
T
L
A
D
S
--
S
----------
L
A
V
N
---
E
H
-------------
E
VEKLIAEEMDGLVKA
S
N
H
---------
Q
I
-------
E
D
A
Y
S
I
R
C
T
P
Q
I
L
G
P
V
A
D
T
L
K
N
I
K
Q
T
L
T
N
E
L
N
S
S
N
D
N
P
L
I
D
Q
T
T
-
E
E
V
--
F
H
N
G
H
F
H
G
Q
Y
V
S
M
A
M
D
H
L
N
I
A
L
V
T
M
M
N
L
A
N
R
R
I
D
-
R
F
M
D
K
S
N
S
-
N
G
L
P
P
F
L
-
C
--
A
E-
N
A
--
G
L
R
L
G
L
M
G
G
Q
F
M
T
A
S
I
T
A
E
S
R
A
S
C
M
P
-
M
S
I
Q
S
L
S
T
T
G
D
F
--
Q
D
I
V
S
F
G
L
V
A
A
R
R
V
R
E
Q
L
K
N
L
K
Y
V
F
S
F
E
L
L
C
A
C
Q
A
V
D
I
R
-------------------
G
---------
T
A
G
--
L
S
K
R
T
R
A
L
Y
D
K
TRTL
V
--
P
Y
L
E
--
E
---------
D
K
T
I
S
D
Y
I
E
S
-
I
A
Q
---------------------------
16
PsiBlast_PDB
59.74
37%
-26
- C8 -
2O7D
3
TALY_RHOS4
A:
[18-516]
--------------
D
L
D
Q
A
H
A
V
A
S
GG
A
R
I
V
L
A
--
P
P
A
R
--
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
---
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
-
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
---
D
F
---
L
-
D
R
D
G
T
--
R
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
-
D
L
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
--
A
----------
R
V
V
R
HVI
A
E
-------------
R
---------------
R
L
D
AGDIGTEPE
A
G
-------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
P
D
-
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
-
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
--
G
--
P
A
--
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
-
A
S
I
H
S
I
S
T
N
A
A
N
--
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
G
---
L
---------
D
G
V
--------
S
P
A
--
G
K
K
L
V
Q
A
L
R
E
Q
----
F
--
P
P
L
E
--
T
---------
D
R
P
L
G
Q
E
I
A
A
L
A
T
H
L
L
-------------------------
15
PsiBlast_PDB
59.58
37%
-25
- C8 -
2O7B
3
TALY_RHOS4
A:
[18-516]
--------------
D
L
D
Q
A
H
A
V
A
S
GG
A
R
I
V
L
A
--
P
P
A
R
--
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
---
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
-
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
---
D
F
---
L
-
D
R
D
G
T
--
R
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
-
D
L
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
--
A
----------
R
V
V
R
HVI
A
E
-------------
R
---------------
R
L
D
AGDIGTEPE
A
G
-------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
P
D
-
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
-
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
--
G
--
P
A
--
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
-
A
S
I
H
S
I
S
T
N
A
A
N
--
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
G
---
L
---------
D
G
V
--------
S
P
A
--
G
K
K
L
V
Q
A
L
R
E
Q
----
F
--
P
P
L
E
--
T
---------
D
R
P
L
G
Q
E
I
A
A
L
A
T
H
L
L
-------------------------
10
PsiBlast_PDB
58.89
35%
-28
- C8 -
2RJS
2
TAM_STRGL
A:
[20-522]
----------
L
T
V
E
A
V
R
R
--
V
A
E
---
E
R
A
T
V
D
--
V
P
A
E
S
I
A
K
A
Q
K
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
E
M
---
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
-
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
M
D
-
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
---
Y
V
---
L
-
R
D
-
G
R
--
P
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
--
G
LT
V
E
H
A
D
L
R
R
E
L
Q
K
---
D
K
-------------
E
---------------
A
G
K
---------
D
V
Q
RSEIYL
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
E
G
K
--
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
-
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
--
S
G-
D
P
--
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
-
A
S
T
Q
S
V
P
S
N
G
D
N
--
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
G
---
L
---------
S
P
---------
A
A
K
A
T
Y
E
A
V
R
R
L
--------
V
--
P
T
L
G
--
V
---------
D
R
Y
M
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
----------------------
9
PsiBlast_PDB
58.87
35%
-27
- C8 -
2RJR
1
TAM_STRGL
A:
[20-522]
----------
L
T
V
E
A
V
R
R
--
V
A
E
---
E
R
A
T
V
D
--
V
P
A
E
S
I
A
K
A
Q
K
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
E
M
---
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
-
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
M
D
-
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
---
Y
V
---
L
-
R
D
-
G
R
--
P
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
--
G
LT
V
E
H
A
D
L
R
R
E
L
Q
K
---
D
K
-------------
E
---------------
A
G
K
---------
D
V
Q
RSEIYL
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
E
G
K
--
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
-
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
--
S
G-
D
P
--
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
-
A
S
T
Q
S
V
P
S
N
G
D
N
--
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
G
---
L
---------
S
P
---------
A
A
K
A
T
Y
E
A
V
R
R
L
--------
V
--
P
T
L
G
--
V
---------
D
R
Y
M
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
----------------------
12
PsiBlast_PDB
58.71
35%
-27
- C8 -
2QVE
2
TAM_STRGL
A:
[9-511]
----------
L
T
V
E
A
V
R
R
--
V
A
E
---
E
R
A
T
V
D
--
V
P
A
E
S
I
A
K
A
Q
K
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
E
M
---
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
-
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
M
D
-
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
---
Y
V
---
L
-
R
D
-
G
R
--
P
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
--
G
LT
V
E
H
A
D
L
R
R
E
L
Q
K
---
D
K
-------------
E
---------------
A
G
K
---------
D
V
Q
RSEIYL
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
E
G
K
--
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
-
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
--
S
G-
D
P
--
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
-
A
S
T
Q
S
V
P
S
N
G
D
N
--
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
G
---
L
---------
S
P
---------
A
A
K
A
T
Y
E
A
V
R
R
L
--------
V
--
P
T
L
G
--
V
---------
D
R
Y
M
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
----------------------