@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : F7Q224_9BACT: (2019-01-28 )
MIMDDKEILQLLRNDFGVSVCNLKRVKSGNIKTVFSFTYERKEYVIRFSKGNNEFETEQFLYKLTHKNDHMARLIKIGTYKNLYYSITERVKGCPLKELNLSKVKTIIPQLIESVTCIHQTDLTPSCGYGWIKDGNGCFSSFRELIETHFKQEQNGFWNDWYTLFEDSFLDYDSFMTLYKEMVRLSPYSDGQRFLTHGDFHFSNIFSDGKMITGIIDWGNVMYGDFILDIAMLHMLYPSLNFKEAFKNYYNTHQIKVENYDKRFICMSLFKGLDTLRFAAKTGDRPFYKSLLNYLQELIAQKKAEDSSYFSHSYKK
Atome Classification :
(20 SA)
--....-.....10.....-.-.--.20.......--..30-........--40-........50.---..--.....60..-....----.--.--70......-------...------80.........90........-----100----------.........110.......120.......------130..-.--.-----....140....----...150.-----.....-.160.......-170.......---180.......190.......200......-.----210.......220.......230.----....---.----.----240.......250.....-..260.......270.......280.......290.......300.......310....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MIM
D
-
D
K
E
I
L
Q
L
L
R
NDF-G-V--
S
V
-
C
N
L
K
RVK--SGN
I
-
K
T
V
F
S
F
T
Y
--
E
R
-
K
E
Y
V
I
R
FSKGN---NE--
F
E
T
E
Q
F
L
Y
K
-LTHK----N--
D
--
H
-
M
A
R
L
I
K-------IGT------
Y
-
K
N
L
Y
Y
S
I
T
E
R
VKGCPLKEL-----
N
------------
L
S
K
V
K
T
I
I
P
Q
L
I
E
S
V
T
C
I
HQTDLTPSCGY------G-WIK-D--G-----
N
G
C
F
S
S
F
R
E
L
I
----
E
T
H
F
K
Q
E-----QNG
F
W
-
N
D
W
Y
T
L
F
E
D
SF-L
D
Y
D
S
F
M
T
L
Y
---
K
E
M
V
RLSPYSDGQ
R
F
L
THGD
F
H
F
S
N
IFSD-G----
K
M
I
T
G
I
IDWGN
V
M
Y
G
D
F
I
L
D
I
A
M
L
----
H
M
LY---P----S----L
N
F
K
E
A
F
K
N
YYN
T
H
Q
I
K
V-ENYD
K
R
F
I
C
M
S
L
F
K
G
L
D
T
L
R
F
AAKTGD
R
P
F
Y
K
S
L
L
N
Y
L
Q
E
L
I
A
Q
KKAEDSSYFSHSYKK-
127
HHSearch
86.36
24%
-41
* C2 *
-
3W0O
2
KHYB_ECOLX
A:
[9-279]
--------
T
S
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
-
H
F
A
S
A---
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
-
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
----
C
A
I
A
D
P
H
-----
V
Y
-----
H
W
Q
T
V
M
D
D
---
T
V
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
--
A
G
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
Y
Q
S
L
V
------------------------------------
121
HHSearch
84.57
23%
-29
- C2 -
-
3W0S
2
KHYB_ECOLX
A:
[6-279]
----
L
T
-
A
T
S
V
E
K
F
L
I
E
K
F
-
D
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
-
H
F
A
S
A---
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
A
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
-
P
F
G
P
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
----
C
A
I
A
D
P
H
-----
V
Y
-----
H
W
Q
T
V
M
D
D
T
---
V
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
S
Q
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
L
A
C
M
E
Q
Q
T
R
Y
F
E
R
R
H
P
E
L
------
A
G
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
Y
Q
S
L
V
------------------------------------
5
PsiBlast_PDB
82.44
23%
-27
- C2 -
-
3W0Q
2
KHYB_ECOLX
A:
[11-274]
----------
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
A
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
4
PsiBlast_PDB
82.03
23%
-28
- C2 -
-
3W0O
2
KHYB_ECOLX
A:
[11-274]
----------
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
1
PsiBlast_PDB
81.93
23%
-33
- C2 -
-
3W0R
2
KHYB_ECOLX
A:
[11-274]
----------
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
A
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
2
PsiBlast_PDB
81.92
23%
-29
- C2 -
-
3W0M
1
KHYB_ECOLX
A:
[11-274]
----------
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
3
PsiBlast_PDB
81.64
23%
-27
- C2 -
-
3W0N
2
KHYB_ECOLX
A:
[11-274]
----------
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
6
PsiBlast_PDB
81.10
23%
-26
- C2 -
-
3W0P
2
KHYB_ECOLX
A:
[11-274]
----------
V
E
K
F
L
I
E
K
F
-
G
----
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
A
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
A
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
7
PsiBlast_PDB
76.21
23%
-13
- C2 -
-
3W0S
2
KHYB_ECOLX
A:
[21-274]
-------------------------
S
V
-
S
D
L
M
Q
L
S
--
E
G
E
E
-
S
R
A
F
S
F
D
V
--
G
G
-
R
G
Y
V
L
R
V
N
S
C
A
---
D
G
--
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
A
----
A
--
L
--
P
-
I
P
E
V
L
D
-------
I
G
E
------
F
S
E
S
L
T
Y
C
I
S
R
R
A
Q
G
V
T
L
Q
D
L
-----
P
------------
E
T
E
L
P
A
V
L
Q
P
V
A
E
A
M
D
A
I
A
A
A
D
L
S
Q
T
S
G
F
------
G
P
F
G
P
-
Q
--
G
-----
I
G
Q
Y
T
T
W
R
D
F
I
C
AIA
D
P
H
V
Y
H
--------------
W
Q
T
V
M
D
D
T
V
---
S
A
S
V
A
Q
A
L
---
D
E
L
M
L
W
A
E
D
C
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
-
N
----
G
R
I
T
A
V
I
D
W
S
E
A
M
F
G
D
S
Q
Y
E
V
A
N
I
----
F
F
W
R
---
P
----
W
----
L
A
C
M
E
Q
Q
T
R
Y
F
E
R
R
H
P
E
L
-
A
G
-
S
P
R
L
R
A
Y
M
L
R
I
G
L
D
Q
L
-----------------------------------------
122
HHSearch
66.12
17%
-15
- C2 -
-
3JR1
3
?
A:
[18-289]
---
Q
G
M
-
W
K
S
I
S
Q
V
L
A
E
Q
F
-
G
-
A
Y
Y
F
I
-
K
H
K
E
K
L
Y
--
S
G
E
M
-
N
E
I
W
L
I
N
D
--
E
V
-
Q
T
V
F
V
K
I
N
E
R
S
Y
R
-
S
M
--
F
R
A
E
A
D
Q
L
A
-
L
L
A
K
T
N--
S
--
I
--
N
-
V
P
L
V
Y
G
-------
I
G
N
------
S
-
Q
G
H
S
F
L
L
L
E
A
L
N
K
S
K
N
------------------------
K
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
--
K
Y
------
G
-
L
D
F
D
T
W
L
G
P
I
Y
Q
P
N
D
W
Q
T
S
W
A
K
F
F
----
S
E
N
---
R
-----
I
G
-----
W
Q
L
Q
I
C
K
E
K
G
-
L
I
F
G
N
I
D
L
I
V
---
Q
I
V
A
D
T
L
S
K
H
N
P
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
-
D
----
D
K
I
F
-
V
C
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
----
S
L
F
E
--------------
P
F
P
T
N
F
Y
Q
R
Y
N
E
I
Y
P
L
E
-
E
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
-------------------------------------
120
HHSearch
65.75
17%
-21
- C2 -
-
3TDW
1
?
A:
[4-298]
-----
N
-
K
L
H
Y
T
T
M
I
M
T
Q
F
-
P
D
I
--
S
I
-
Q
S
V
E
S
L
G
--
E
G
F
R
-
N
Y
A
I
L
V
N
------
G
D
W
V
F
R
F
P
K
S
Q
Q
G
A
D
E
--
L
N
K
E
I
Q
L
L
P
-
L
L
V
G
CV--
K
--
V
--
N
-
I
P
Q
Y
V
Y
-------
I
G
K
R
-----
S
-
D
G
N
P
F
V
G
Y
R
K
V
Q
G
Q
I
L
G
E
D
G
M
A
V
L
P
------------
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
------
G
-
V
--------------
P
V
T
N
L
K
N
K
I
----
L
L
L
S
E
A
V
-----
E
D
Q
-----
V
F
P
L
L
D
E
-
S
-
L
-
R
D
Y
L
T
L
R
F
---
Q
S
Y
M
T
H
P
V
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
-
L
NSRQ
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
----
L
E
D
C
---
G
----
E
------
L
F
T
R
Q
V
M
A
Y
R
G
E
V
D
L
D
--
T
H
I
R
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
A
-----------------
105
Fugue
65.37
15%
-78
- C2 -
-
3HAM
3
?
A:
[1-299]
--
M
V
N
L
-
D
A
E
I
Y
E
H
L
N
K
Q
I
-
K
-
I
--
N
---
E
L
R
Y
L
S
--
S
G
D
D
-
S
D
T
F
L
C
N
E
--
Q
Y
-
V
V
K
V
P
K
R
D
S
V
R
---
I
S
--
Q
K
R
E
F
E
L
Y
R
-
F
L
-
E
----
N
--
C
--
K
-
L
S
Y
Q
I
P
-------
A
V
V
------
Y
-
Q
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
-----
Q
------------
Y
H
K
L
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
------
C
-
S
V
S
-
L
--
F
-----
S
D
A
L
V
N
K
K
D
K
F
----
L
Q
D
K
K
L
L
-----
I
S
I
L
E
-
K
E
----
Q
L
L
T
D
-
E
M
L
E
H
I
E
T
I
Y
---
E
N
I
L
N
N
A
V
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
-
N
----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
----
L
D
C
S
---
T
----
D
DFG-
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
--
A
P
-
E
V
A
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
------------
106
Fugue
65.04
16%
18
- C2 -
-
3JR1
3
?
A:
[14-309]
N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
-
G
-
A
--
Y
Y
F
I
K
H
K
E
K
L
--
Y
S
G
E
M
N
E
I
W
L
I
N
D
--
E
V
-
Q
T
V
F
V
K
I
N
E
R
S
---
Y
R
S
M
F
R
A
E
A
D
Q
L
A
-
L
L
A
K
----
T
--
N
S
I
N
-
V
P
L
V
Y
G
-------
I
G
N
------
S
-
Q
G
H
S
F
L
L
L
E
A
L
N
K
S
K
N
K
------------------------
Q
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
K
Y
G
L
D
F
D
T
W
L
G
-
P
I
Y
-
Q
--
P
-----
N
D
W
Q
T
S
W
A
K
F
F
----
S
E
N
R
------------
I
-
G
W
Q
L
Q
I
C
K
E
K
G
-
L
I
F
G
N
I
D
L
I
V
---
Q
I
V
A
D
T
L
S
K
H
N
P
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
-
D
----
D
--
K
I
F
V
C
N
P
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
----
S
L
F
E
--------------
P
F
P
T
N
F
Y
Q
R
Y
N
E
I
Y
P
L
E
-
E
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
K
-----
K
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
------------
131
HHSearch
61.70
18%
19
- C2 -
-
5IQI
1
AACA_STAAU
C:
[9-289]
---
A
T
N
-
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
-
F
--
K
V
-
D
S
I
E
I
I
G
--
S
G
Y
D
-
S
V
A
Y
L
V
N
------
N
E
Y
I
F
K
T
K
F
S
T
NKK
K
G
--
F
A
K
E
K
A
I
Y
N
-
F
L
N
T
N
LET
N
--
V
--
K
-
I
P
N
I
E
Y
-------
S
Y
I
------
S
-
D
E
L
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
I
Y
S
T
M
S
------------
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
---
I
------
S
-
E
C
T
-
I
--
D
------
N
K
Q
N
V
L
E
E
Y
I
----
L
-----
L
-----
R
E
-----
T
I
Y
N
D
L
T
D
---
I
E
K
D
Y
I
E
S
F
M
---
E
R
L
N
A
T
-
T
V
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
-
G
N---
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
----
L
E
D
S
EEE
I
----
G
----
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
--
D
I
-
E
K
A
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
-------------------------------
132
HHSearch
61.04
15%
-30
- C2 -
-
3I1A
4
?
B:
[5-290]
---
P
I
Q
-
A
Q
Q
L
I
E
L
L
K
V
H
Y
-
G
-
I
--
D
I
-
H
T
A
Q
F
I
Q
--
G
G
A
D
-
T
N
A
F
A
Y
Q
A
D
S
E
S
-
K
S
Y
F
I
K
L
K
Y
G
Y
---
H
---
D
E
I
N
L
S
I
I
R
-
L
L
H
D
S
---
G
--
I
--
K
E
I
I
F
P
I
H
-------
T
L
E
AKL
F
Q
Q
L
-
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
F
T
Q
-----
N
--------------
L
T
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
-
I
Q
------
Q
-
Q
L
R
----
K
-----
E
I
Y
S
P
K
W
R
E
I
V
----
R
S
F
Y
N
Q
I
-----
E
F
D
N
S
D
D
K
L
T
A
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
L
S
K
K
I
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
-
N
----
E
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
----
G
G
G
V
---
G
NVWN
K
----
P
H
E
I
Q
Y
F
Y
E
G
Y
G
E
I
N
V
-----
D
K
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
----------------------------------------
125
HHSearch
59.62
14%
-21
- C2 -
-
5IWU
2
?
A:
[1-284]
--
M
S
K
D
-
I
K
Q
V
I
E
I
A
K
K
H
N
-
L
F
L
--
K
E
-
E
T
I
Q
F
N
E
--
S
G
L
D
-
F
Q
A
V
F
A
Q
D
--
N
N
G
I
D
W
V
L
R
L
P
R
R
E
D
V
M
P
R
--
T
K
V
E
K
Q
A
L
D
-
L
V
N
K
Y---
A
IS
F
--
Q
-
A
P
N
W
I
I
-------
Y
-----------
T
E
E
L
I
A
Y
K
K
L
D
G
V
P
A
G
T
I
-----
D
HNIGNYIWEIDI
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
P
S
N
K
A
A
A
L
------
D
-
L
V
V
H
T
--
P
-----
E
E
A
R
M
S
M
K
Q
R
M
----
D
------------------
A
V
R
A
K
F
---
G
-
V
G
E
N
L
W
N
R
-
W
---
Q
A
W
L
N
D
D
D
M
W
P
K
K
T
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
D
----
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
----
Y
R
A
F
---
G
----
E
-----
E
G
L
E
A
L
I
L
A
Y
K
E
I
G
G
Y
Y
W
P
K
M
K
E
H
I
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
S
-----------------------------------
133
HHSearch
58.40
17%
23
- C2 -
-
5IQC
2
AACA_STAAU
A:
[10-289]
----
T
N
-
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
-
F
--
K
V
-
D
S
I
E
I
I
G
--
S
G
Y
D
-
S
V
A
Y
L
V
N
------
N
E
Y
I
F
K
T
K
F
S
T
NKK
K
G
--
Y
A
K
E
K
A
I
Y
N
-
F
L
N
T
N
LET
N
--
V
--
K
-
I
P
N
I
E
Y
-------
S
Y
I
------
S
-
D
E
L
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
I
Y
S
T
M
S
------------
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
---------
S
-
E
C
T
----
I
-----
D
N
K
Q
N
V
L
E
E
Y
I
----
L
-----
L
-----
R
E
-----
T
I
Y
N
D
L
T
D
---
I
E
K
D
Y
I
E
S
F
M
---
E
R
L
N
A
T
-
T
V
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
N
----
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
----
L
E
D
S
EEE
I
----
G
----
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
--
D
I
-
E
K
A
K
E
Y
Q
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
-------------------------------
104
Fugue
57.75
11%
28
- C2 -
-
3I1A
2
?
A:
[3-330]
-K
Q
P
I
Q
-
A
Q
Q
L
I
E
L
L
K
V
H
Y
-
G
-
I
--
D
I
-
H
T
A
Q
F
I
Q
GG
A
D
T
N
-
A
F
A
Y
Q
A
D
S
--
E
S
-
K
S
Y
F
I
K
L
K
Y
G
Y
---
H
D
--
E
I
N
L
S
I
I
R
L
-
L
H
D
S
----
G
--
I
--
K
-
E
I
I
F
P
I
HTLEAKL
F
Q
Q
------
L
-
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
F
T
Q
-----
N
------------
L
T
--
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
I
Q
Q
------
Q
-
L
R
K
-
E
--
I
-----
Y
S
--
P
K
W
R
E
I
V
----
R
S
F
Y
N
Q
I
EFDNS
D
D
K
L
T
-
A
A
F
K
S
F
F
N
Q
N
S
-
A
A
I
H
R
L
V
D
T
S
---
E
K
L
S
K
K
I
Q
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
-
N
----
E
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
GGGV
G
N
V
W
---
N
----
K
----
P
H
E
I
Q
Y
F
Y
E
G
Y
G
E
I
N
V
D
-----
K
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
S
R
N
Q
N
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E
139
HHSearch
57.43
15%
-14
- C2 -
-
1ND4
1
KKA2_KLEPN
A:
[10-262]
--------
G
S
P
A
A
W
V
E
R
L
F
-
G
-
Y
--
D
---
W
A
Q
Q
T
I
--
G
C
S
D
-
A
A
V
F
R
L
S
A
--
Q
G
R
P
V
L
F
V
K
T
D
L
S
G
AL-
N
E
--
L
Q
D
E
A
A
R
L
S
-
W
L
A
T
T
---
G
--
V
--
P
-
C
A
A
V
L
D
-------
V
V
T
------
E
-
A
G
R
D
W
L
L
L
G
E
V
P
G
Q
D
L
L
S
S
-----
H
------------
L
-
A
P
A
E
K
V
S
I
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
C
-
P
F
------
D
-
H
Q
-----
A
-----
K
H
R
I
E
R
A
R
T
R
M
----
E
A
G
L
V
D
Q
-------
D
----
D
L
D
E
E
------
H
Q
G
L
A
P
A
E
L
F
---
A
R
L
K
A
R
M
-
P
D
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
-
N
----
G
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
----
T
R
D
I
A
E
E
L
----
G
----
G
E
W
A
D
R
F
L
V
L
Y
G
I
A
-
A
----
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
---------------------------------------------
126
HHSearch
56.73
14%
-11
- C2 -
-
5UXA
-
?
A:
[2-284]
---
S
K
D
-
I
K
Q
V
I
E
I
A
K
K
H
N
-
L
F
L
--
K
E
-
E
T
I
Q
F
N
E
--
S
G
L
D
-
F
Q
A
V
F
A
Q
D
--
N
N
G
I
D
W
V
L
R
L
P
R
R
E
D
V
M
P
R
--
T
K
V
E
K
Q
A
L
D
-
L
V
N
K
Y---
A
IS
F
--
Q
-
A
P
N
W
I
I
-------
Y
-----------
T
E
E
L
I
A
Y
K
K
L
D
G
V
P
A
G
T
I
-----
D
HNIGNYIWEIDI
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
P
S
N
K
A
A
A
L
------
D
-
L
V
V
H
T
--
P
-----
E
E
A
R
M
S
M
K
Q
R
M
----
D
------------------
A
V
R
A
K
F
---
G
-
V
G
E
N
L
W
N
R
-
W
---
Q
A
W
L
N
D
D
D
M
W
P
K
K
T
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
D
----
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
----
Y
R
A
F
---
G
----
E
-----
E
G
L
E
A
L
I
L
A
Y
K
E
I
G
G
Y
Y
W
P
K
M
K
E
H
I
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
S
-----------------------------------