@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q08P17_STIAD: (2019-02-01 )
MAVYTVLDSGAFARIAGAFGLGEVQTVDAIPEGSINTNHRVLTSSGRFFVRHTTVRSAEVLRFEAALLAHLAESHFPGPTPVLTVQGEPFLELQGGRVTVFRWLAGEELQRSQLTPVHLERLGHELGKMHRLTQSFGGSRDNPYSAAQVQVWLKGLRSNSDAEVASVAVELEGYLARAEQERGGGLEPQGVIHADLFMDNVKWLADRVGAFFDFEMACRDAYALDVAITLNAWCFDGDYLPELCQAFFRGYQDARPLSAVEREHLFGHALFGAVRYTASRIRDFHLSPLPAEQLTRKSFRTYLARARTLVSLGPAGFLARMGL
Atome Classification :
(20 SA)
------------------.......-.-----.10......-..------20-.-.......30....-..-..--40-...-.-----------..--.---------..50..-...----.---.-.60.-........70..-..-..-.-.80........----90..----......100.......110.-.-.-....120.-......130----..--...--..-------..140--.--.------------.------..----...------------150.----------..-.----.--------------..-----------------.--160-------.---------.-------.-----..------.-----------..170-----..----------.......---180-----.-----..---.---..------------...190...-----....200--.....--.-----...210.......220-.......-.230--....--..--------------.----------------.---------------240------------.......-..250.--..------.--------...-----260...-.....270........280---...------.....290.......-300.......310..-----.....320.----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------
M
A
V
Y
T
VL-D-----SG
A
F
A
R
I
A
G-AF------GL-G-E
V
Q
T
VDAIPEGSI-NT-N
H
--
R
--
V
L
T-S-----------S
G
--
R
---------
F
F
V
R
H
T-TVR----
S
---
A
-
E
V
-
L
-
R
F
E
A
A
L
L
A
H
L
A
E
-SH-FP-G-PT
P
V
L
T
VQG
E
P
----
F
L
E
L----QG
G
R
V
T
V
F
R
WLAG
E
E
L
Q
RSQ-L-
T
-
P
V
H
L
E
R
L
G
-
H
E
L
G
K
M
H
------
R
L
--
T
Q
S--FG-------GSRD---N--P------------Y------
S
A
----
A
Q
V
------------
Q
V
-
W
----------
L
K
-
G
----L--------------RS-----------------N--SD--------A---------E-------
V
-----
A
S
------
V
-----------
A
V
E
-------
L
E
----------
G
Y
L
A
R
A
E
---
Q
-------E-----RG---G---GL------------EPQ
G
V
I
H
A
D
-----
L
F
M
D
N
----
V
K
W
L
A
--
D
-----
R
V
G
A
F
F
D
F
E
M
A
CR
D
A
--
Y
A
L
D
V
A
I
-
T
L
N
---
A
W
CF--DG--------------
D
----------------
Y
---------------
L
--------------
P
E
L
C
Q
A
F
-
F
R
GYQD--AR------
P
--------
L
S
A
-----
V
E
-
R
E
H
-
L
F
G
H
A
L
-
F
G
A
V
R
Y
T
A
S
R
I
----
R
DF------HLSPL
P
A
E
Q
L
T
R
K
S
F
-
R
T
Y
L
A
R
A
R
T
L
VSLG
P
-----
A
G
F
L
A
RMGL----
28
HHSearch
97.83
29%
-94
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-318]
----------------------
T
D
I
-
T
-----
E
D
E
L
R
N
F
L
T
-
Q
Y
------
D
V
-
G
-
S
L
T
S
Y
K
G
I
A
E
----
N
S
-
N
F
--
L
--
L
H
T
-
T
-----------
K
D
--
P
---------
L
I
L
T
L
Y
-
E
K
---------
K
-
N
D
-
L
-
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
-
L
S
-
C
-
P
L
P
L
P
R
K
D
G
E
L
----
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
L
R
K
---
P
-
E
-
A
K
H
C
R
E
V
G
-
K
A
L
A
A
M
H
------
L
A
--
S
E
G
--
F
E
-------
I
K
R
P
---
N
--
A
------------
L
------
S
V
----
D
G
W
------------
K
V
-
L
----------
W
D
-
K
----
S
--------------
E
E
-----------------
R
--
A
D
--------
E
---------
V
-------
E
-----
K
G
------
L
-----------
R
E
E
-------
I
R
----------
P
E
I
D
Y
L
A
---
A
-------
H
-----
W
----
P
---
K
D
------------
L
P
A
G
V
I
H
A
D
-----
L
F
Q
D
N
----
V
F
F
L
G
--
D
-----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
--
L
A
Y
D
V
S
I
-
C
L
N
---
A
W
C
F
--
E
K
DG------------
A
----------------
Y
---------------
N
--------------
V
T
K
G
K
A
L
-
L
E
G
Y
Q
S
--
V
R
------
P
--------
L
S
E
-----
A
E
-
L
E
A
-
L
P
L
L
S
R
-
G
S
A
L
R
F
F
L
T
R
L
----
Y
D
W
------
L
T
T
P
-
A
G
A
L
V
V
K
K
D
P
-
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
-----
V
A
E
Y
G
--------
1
PsiBlast_PDB
89.94
30%
-88
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-306]
----------------------
T
D
I
-
T
-----
E
D
E
L
R
N
F
L
T
-
Q
Y
------
D
V
-
G
-
S
L
T
S
Y
K
G
I
A
E
----
N
S
-
N
F
--
L
--
L
H
T
-
T
-----------
K
D
--
P
---------
L
I
L
T
L
Y
-
E
K
---------
K
-
N
D
-
L
-
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
-
L
S
-
C
-
P
L
P
L
P
R
K
D
G
E
L
----
L
G
E
L
----
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
L
R
K
P
E
-
A
-
K
---
H
C
R
E
V
G
-
K
A
L
A
A
M
H
------
L
A
--
S
E
G
--
F
E
-------
I
K
R
P
---
N
--
A
------------
L
------
S
V
----
D
G
W
------------
K
V
L
W
D
K
S
EERADEV
E
K
-
G
----
L
--------------
R
E
-----------------
E
--
I
R
--------
P
---------
E
-------
I
-----
D
Y
------
L
-----------
A
A
H
-------
W
P
----------
K
D
L
---------------------------------------------
P
A
G
V
I
H
A
D
-----
L
F
Q
D
N
----
V
F
F
L
G
--
D
-----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
--
L
A
Y
D
V
S
I
-
C
L
N
---
A
W
C
F
EK
D
G
--------------
A
----------------
Y
---------------
N
--------------
V
T
K
G
K
A
L
-
L
E
G
Y
Q
S
--
V
R
------
P
--------
L
S
E
-----
A
E
-
L
E
A
-
L
P
L
L
S
R
-
G
S
A
L
R
F
F
L
T
R
L
----
Y
D
W
------
L
T
T
P
A
G
A
-
L
V
V
K
K
D
P
-
L
E
Y
L
R
K
L
R
-------------------------
17
Fugue
72.96
20%
6
- C3 -
-
4OCV
2
?
A:
[24-378]
--------------------------
T
-----
N
E
A
L
F
D
V
A
S
-
H
F
------
A
L
E
G
-
T
V
D
S
I
E
P
Y
G
D
G
H
I
-
N
T
-
T
Y
--
L
--
V
T
T
-
D
-----------
G
P
--
R
---------
Y
I
L
Q
R
M
-
N
T
G
IFPD
T
---
V
-
N
L
-
M
-
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
-
K
E
-
T
-
L
D
I
V
R
T
T
S
G
D
T
----
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
M
S
Y
N
L
V
-
P
-
N
-
P
D
V
F
R
E
A
G
-
R
A
F
G
D
F
Q
------
N
F
--
L
S
G
--
F
D
-------
A
N
Q
L
---
T
--
E
------------
T
IAHFHD
T
P
----
H
R
F
------------
E
D
-
F
----------
K
K
-
A
----
L
--------------
A
A
-----------------
D
--
E
L
--------
G
---------
R
-------
A
-----
A
G
------
C
-----------
G
P
E
-------
I
E
----------
F
Y
L
S
H
A
D
---
Q
YA
V
V
M
D
G
L
-----
R
D
---
G
---
S
I
-------------
P
L
R
V
T
H
N
D
TKLNN
I
L
M
D
A
TTGK
A
R
A
I
I
--
D
LDTIM
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
AS
T
A
L
E
D
E
R
-
D
L
D
---
K
V
H
F
--
S
T
--------------
E
----------------
L
---------------
F
--------------
R
A
Y
T
E
G
F
-
V
G
E
L
R
D
----------
S
--------
I
T
A
-----
R
E
-
A
E
L
-
L
P
F
S
G
N
-
L
L
T
M
E
C
G
M
R
F
L
----
A
D
Y
L
E
GDVY
F
A
T
K
Y
P
E
H
N
L
V
R
S
R
T
-
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
-----
R
A
I
V
A
D
V
M
E
T
T--
30
HHSearch
63.81
21%
-38
- C3 -
-
4PDY
1
?
A:
[21-304]
--------------------------------
P
L
I
P
Q
A
V
V
S
-
K
Y
------
D
L
-
A
--
I
Q
Q
---
R
H
A
----
D
G
-
N
I
--
E
--
V
W
T
D
S
-----------
K
G
R
-
R
---------
Y
A
A
K
R
S
-
S
I
-----
A
---
P
-
A
H
-
C
-
R
I
M
V
Q
C
L
R
H
A
Q
E
-
Q
G
-
F
T
K
F
-
A
R
F
V
T
T
S
S
N
A
P
----
Y
V
R
H
----
G
D
F
T
Y
Y
V
T
E
W
V
S
G
Q
P
A
N
F
---
G
-
L
-
P
E
H
V
A
Q
T
A
-
Y
T
L
A
Q
F
H
------
E
A
--
T
R
S
--
F
R
-------
T
D
W
K
----------------------------DD
V
F
G
L
F
------------
Q
A
-
R
----------
W
R
-
D
----
L
--------------
R
Q
-----------------
M
--
W
L
--------
G
A
D
R
KREKD
A
F
D
Q
L
L
L
S
M
R
-----
D
E
------
L
-----------
H
R
D
-------
A
A
----------
E
S
L
A
L
F
E
---
D
R
D
V
I
A
--
Y
-----
L
E
---
A
---
E
R
------------
S
S
G
G
W
C
H
L
D
-----
V
I
P
S
N
----
C
L
Y
T
P
--
Q
-----
H
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
--
R
A
L
D
M
A
H
-
L
L
R
---
R
S
L
E
--
R
G
--------------
N
----------------
W
---------------
D
--------------
G
H
L
A
Y
A
C
-
F
L
H
F
D
A
--
V
R
------
N
--------
I
P
K
-----
S
E
-
Y
R
A
-
V
E
A
I
L
R
-
F
P
Y
L
---------------------------------------------------------------------
31
HHSearch
63.08
13%
-80
- C3 -
-
2Q83
4
COTI_BACSU
A:
[22-307]
----------------------------------
L
A
E
N
V
L
Q
-
G
W
------
D
V
---
Q
A
E
K
I
D
V
I
Q
-----
A
L
-
V
W
--
K
--
V
H
T
-
D
-----------
S
G
--
A
---------
V
C
L
K
R
I
-
H
R
-----
P
---
E
-
K
K
-
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
G
-
M
N
-
V
-
P
G
I
L
P
N
K
K
G
S
L
----
Y
S
K
H
----
G
S
F
L
F
V
V
Y
D
W
I
E
G
R
P
F
E
L
---
T
-
V
-
K
Q
D
L
E
F
I
M
-
K
G
L
A
D
F
H
------
T
A
--
S
V
G
--
Y
Q
-------
P
P
N
G
V
--
P
--
I
F
-----------
T
------
K
L
----
G
R
W
------------
P
N
-
H
----------
Y
T
-
K
R
C
K
Q
M
--------------
E
T
-----------------
W
--
K
L
M
A
E
A
E
KED
P
---------
F
-------
S
Q
L
Y
L
-
Q
E
I
D
G
---
F
-----------
I
E
D
-------
G
L
----------
R
I
K
D
R
L
L
---
Q
-------
S
T
Y
V
P
W
T
E
---
Q
---
L
K
------------
K
S
P
N
L
C
H
Q
D
-----
Y
G
T
G
N
----
T
L
L
G
E
--
N
-----
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
--
P
I
R
D
L
R
K
-
M
I
I
---
P
L
L
D
--
T
T
G-------------
V
----------------
W
---------------
D
--------------
D
E
T
F
N
V
M
-
L
N
A
Y
E
S
--
R
A
------
P
--------
L
T
E
-----
E
Q
-
K
Q
V
-
M
F
I
D
M
L
-
F
P
Y
----------------------------------------------------------------------
14
Fugue
62.62
16%
0
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-----------------S
A
F
T
F
Q
T
L
-
H
-----
P
D
T
I
M
D
A
L
F
-
E
H
------
G
I
-
R
-
V
D
S
G
L
T
P
L
N
-
S
Y
E
-
N
R
-
V
Y
--
Q
--
F
Q
D
-
E
-----------
D
R
--
R
---------
R
F
V
V
K
F
-
Y
R
P
ERW-
T
---
A
-
D
Q
-
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
-
V
P
-
V
-
A
A
P
-
V
A
F
N
G
Q
T
----
L
L
N
H
----
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
Q
F
E
A
D
----
N
-
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
------
Q
T
--
G
R
K
--
Q
L
FIHRPTI
G
L
N
E
---
Y
--
L
------------
I
------
E
P
----
R
K
L
------------
F
E
-
D
----------
A
T
-
L
----
I
--------------
P
S
-----------------
G
--
L
K
--------
A
---------
A
-------
F
-----
L
K
------
A
-----------
T
D
E
-------
L
I
----------
A
A
V
T
A
H
W
---
R
-------
E
-----
D
----------------------
F
T
V
L
R
L
H
G
D
-----
C
H
A
G
N
----
I
L
W
R
D
--
G
-------
P
M
F
V
D
L
D
D
A
R
N
G
P
--
A
V
Q
D
L
W
M
-
L
L
N
---
G
D
-----
K
--------------
A
----------------
E
---------------
Q
--------------
R
M
Q
L
E
T
I
-
I
E
A
Y
E
E
--
F
S
------
E
--------
F
D
T
-----
A
E
-
I
G
L
-
I
E
P
L
R
A
-
M
R
L
V
Y
Y
L
A
W
L
M
----
R
R
W
------
A
D
P
A
F
P
K
N
F
P
W
L
T
G
E
-
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
-----
V
L
Q
E
P
P
L
Q
L
TPMY
29
HHSearch
59.87
20%
-13
- C3 -
-
6EF6
2
?
A:
[27-312]
--------------------------
D
-----
V
T
I
A
Q
Q
A
L
T
-
H
Y
------
D
V
-
S
-
D
N
A
S
L
R
L
L
-
N
L
S
E
-
N
A
-
T
Y
--
L
--
V
E
D
-
G
-----------
E
H
--
Q
---------
S
I
L
R
V
H
-
R
Q
D
YH--
Q
---
P
-
H
E
-
I
-
E
S
E
L
D
W
L
A
A
L
R
T
D
S
D
-
V
T
-
V
-
P
T
V
V
P
A
R
D
G
R
R
----
V
V
T
V
D
P
A
D
V
P
R
H
V
V
H
F
E
M
V
G
G
A
E
P
D
E
E
S
-
L
-
T
-
L
D
D
F
Q
T
L
G
-
R
I
T
A
S
L
H
------
E
H
--
S
Q
R
--
W
T
-------
R
P
A
G
F
G
R
F
--
S
------------
W
------
D
W
----
E
H
C
------------
L
G
-
D
----------
T
P
-
R
----
W
--------------
G
R
-----------------
W
--
Q
D
AE------
G
---------
V
-------
G
-----
A
S
------
E
-----------
T
A
L
-------
L
T
----------
R
A
Q
D
L
L
H
---
R
-------
K
-----
L
E
---
E
Y
GS
G
P
------------
D
R
Y
G
L
I
H
A
D
-----
L
R
L
A
N
----
L
L
V
D
S
--
S
TPQ--
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
--
Y
F
Y
D
F
G
T
-
A
V
S
---
F
I
E
H
--
D
---------------
P
----------------
R
---------------
L
--------------
G
E
W
Q
E
S
W
-
V
A
G
Y
R
S
--
R
R
------
E
--------
L
P
A
-----
A
D
-
E
A
M
-
L
P
S
F
V
F
-
L
R
R
L
---------------------------------------------------------------------
33
HHSearch
59.47
16%
-8
- C3 -
-
4OCV
2
?
A:
[24-321]
--------------------------
T
-----
N
E
A
L
F
D
V
A
S
-
H
F
------
A
L
-
E
G
T
V
D
S
I
E
P
Y
G
D
G
H
I
-
N
T
-
T
Y
--
L
--
V
T
T
-
D
-----------
G
P
--
R
---------
Y
I
L
Q
R
M
-
N
T
G
----
I
FPD
T
-
V
N
-
L
M
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
-
K
E
-
T
-
L
D
I
V
R
T
T
S
G
D
T
----
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
M
S
Y
N
L
V
-
P
-
N
-
P
D
V
F
R
E
A
G
-
R
A
F
G
D
F
Q
------
N
F
--
L
S
G
--
F
D
-------
A
N
Q
L
---
T
--
E
TI----------
A
------
H
F
----
H
D
T
------------
P
H
-
R
----------
F
E
-
D
----
F
--------------
K
K
-----------------
A
--
L
A
A
DELG---
R
---------
A
AG-----
C
-----
G
P
------
E
-----------
I
E
F
-------
Y
L
----------
S
H
A
D
Q
Y
A
---
V
-------
V
-----
M
D
G
L
-
R
D
--
G
S
------------
I
P
L
R
V
T
H
N
D
-----
T
K
L
N
N
----
I
L
M
D
A
TT
G
-----
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
--
M
L
F
D
F
G
D
-
S
I
R
---
F
G
A
S
--
T
A
LEDERDLDK
V
----
H
----------------
F
---------------
S
--------------
T
E
L
F
R
A
Y
-
T
E
G
F
V
G
E
L
R
D
------
S
--------
I
T
A
-----
R
E
-
A
E
L
-
L
P
F
S
G
N
-
L
L
T
M
---------------------------------------------------------------------
50
SP3
58.70
17%
-1
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----------G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
-
N
TI
P
E
L
K
E
R
A
H
M
L
C
A
-
R
F
LGGAWK
T
V
-
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
M
-
L
F
--
L
--
C
R
L
-
S
-----------
E
V
--
Y
PPIRNEPN
K
V
L
L
R
V
Y
F
N
P
E
----
T
---
E
-
S
H
-
L
-
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
-
L
--
G
-
P
K
L
Y
G
I
F
S
G
------------------
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
-
I
S
L
-
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
------
Q
----
L
E
--
V
P
-------
I
W
K
E
---
P
--
D
------------
Y
------
L
C
----
E
A
L
------------
Q
R
-
W
----------
L
K
-
Q
----
L
--------------
T
G
-----------------
T
--
V
D
--------
A
---------
E
-------
H
R
F
D
L
P
E
E
------
C
GVSSVN-----
C
L
D
-------
L
A
----------
R
E
L
E
F
L
R
---
A
-------
H
-----
I
S
---
L
---
S
K
------------
S
P
V
T
F
C
H
N
D
-----
L
Q
E
G
N
----
I
L
L
P
K
--
R
-------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
--
R
A
F
D
F
A
N
-
H
F
I
---
E
W
T
I
--
D
Y
--------------
D
----------------
I
---------------
D
EAPF
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
-
F
L
N
Y
L
R
--
E
Q
GNTREN
E
--------
L
Y
K
-----
K
S
-
E
D
L
-
V
Q
E
T
L
P
-
F
V
P
V
S
H
F
F
W
G
V
----
W
G
L
------
L
Q
V
E
L
S
P
V
G
F
---
G
F
-
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
-----
Q
L
L
K
N
L
A
------
35
HHSearch
57.54
17%
-7
* C3 *
-
4WH3
8
NAHK_BIFL2
A:
[4-299]
--------------------------
S
-----
N
E
V
L
F
G
I
A
S
-
H
F
------
A
L
E
G
-
A
V
T
G
I
E
P
Y
G
D
G
H
I
-
N
T
-
T
Y
--
L
--
V
T
T
-
D
-----------
G
P
--
R
---------
Y
I
L
Q
Q
M
-
N
T
S
----
I
FPD
T
V
N
L
-
M
-
R
N
V
E
L
V
T
S
T
L
K
A
-
Q
G
-
K
E
-
T
-
L
D
I
V
P
T
T
S
G
A
T
----
W
A
E
I
----
D
G
G
A
W
R
V
Y
K
F
I
E
H
T
V
S
Y
N
L
V
-
P
-
N
-
P
D
V
F
R
E
A
G
-
S
A
F
G
D
F
Q
------
N
F
--
L
S
E
--
F
D
-------
A
S
Q
L
---
T
--
E
TI----------
A
------
H
F
----
H
D
T
------------
P
H
-
R
----------
F
E
-
D
----
F
--------------
K
A
-----------------
A
--
L
A
A
DKLG---
R
---------
A
AA-----
C
-----
Q
P
------
E
-----------
I
D
F
-------
Y
L
----------
S
H
A
D
Q
Y
A
---
V
-------
V
-----
M
D
G
L
R
D
---
G
S
------------
I
P
L
R
V
T
H
N
D
-----
T
K
L
N
N
----
I
L
M
D
A
TT
G
-----
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
--
M
L
F
D
F
G
D
-
S
I
R
---
F
G
A
S
--
T
A
LEDEKDLSK
V
----
H
----------------
F
---------------
S
--------------
T
E
L
F
R
A
Y
-
T
E
G
F
V
G
E
L
R
G
------
S
--------
I
T
A
-----
R
E
-
A
E
L
-
L
P
F
S
G
N
-
L
L
-----------------------------------------------------------------------
4
PsiBlast_PDB
53.93
22%
-0
- C3 -
-
4PDY
1
?
A:
[34-291]
-------------------------------------------------------------
A
I
Q
Q
R
H
A
-
D
G
-
N
I
--
E
--
V
W
T
-
D
-----------
S
K
G
R
R
---------
Y
A
A
K
R
S
-
S
I
A
----
P
---
A
-
H
C
---
R
I
M
V
Q
C
L
R
H
A
Q
E
-
Q
G
-
F
T
-
K
F
A
R
F
V
T
T
S
S
N
A
P
----
Y
V
R
H
----
G
D
F
T
Y
Y
V
T
E
W
V
S
G
Q
P
A
N
F
G
----
L
-
P
E
H
V
A
Q
T
A
-
Y
T
L
A
Q
F
H
------
E
A
--
T
R
S
--
F
R
-------
T
D
W
K
--------------------------------
D
D
V
F
G
L
F
Q
A
R
W
R
D
L
R
Q
M
-
W
----------
L
G
-
A
----
D
--------------
R
K
REKD
A
F
D
Q
L
L
L
S
M
R
D
E
L
H
--
R
D
--------
A
---------
A
-------
E
-----
S
L
------
A
-----------
L
F
E
-------
D
R
----------
D
V
I
A
Y
L
E
---
A
-------
E
-----
R
S
---
S
---
G
----------------
G
W
C
H
L
D
-----
V
I
P
S
N
----
C
L
Y
T
P
--
Q
-----
H
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
--
R
A
L
D
M
A
H
-
L
L
R
---
R
S
L
E
--
R
G
--------------
N
----------------
W
---------------
D
--------------
G
H
L
A
Y
A
C
-
F
L
H
F
D
A
--
V
R
------
N
--------
I
P
K
-----
S
E
-------------------------------------------------------------------------------------
15
Fugue
53.37
12%
-18
- C3 -
-
3I1A
2
?
A:
[3-330]
--------------------
K
Q
P
I
Q
-
A
-----
Q
Q
L
I
E
L
L
K
V
-
H
Y
------
G
I
---
D
I
H
T
A
Q
F
I
Q
G
G
A
D
-
T
N
-
A
F
A
Y
Q
--
A
D
S
-
E
-----------
S
K
--
S
---------
Y
F
I
K
L
K
-
Y
G
Y
----
H
---
D
-
E
I
-
N
-
L
S
I
I
R
L
L
H
D
S
G
I
-
K
E
-
I
I
-
F
-
P
I
H
T
L
E
--
A
K
L
----
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
F
T
Q
N
-
L
-
T
-
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
I
--
Q
Q
Q
--
L
R
-------
K
E
I
Y
---
S
--
P
------------
K
------
W
R
----
E
I
V
------------
R
S
-
F
----------
Y
N
-
Q
----
I
--------------
E
F
-----------------
D
NS
D
D
--------
K
---------
L
-------
T
-----
A
A
------
F
-----------
K
S
F
-------
F
N
Q
N
S
A
A
I
H
R
L
V
D
T
S
E
K
L
S
---
K
-------
K
-----
I
Q
---
P
---
D
L
------------
D
K
Y
V
L
C
H
S
D
-----
I
H
A
G
N
----
V
L
V
G
N
--
E
-----
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
--
K
E
R
D
L
M
F
-
I
G
G
GVG
N
V
W
N
--
K
P
--------------
H
----------------
E
---------------
I
--------------
Q
Y
F
Y
E
G
Y
-
G
E
I
N
V
D
--
K
T
------
I
--------
L
S
Y
-----
Y
R
-
H
E
R
-
I
V
-
E
D
I
-
A
V
Y
G
Q
D
L
L
S
R
N
----
Q
N
N
------
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
-
P
N
N
V
V
E
I
A
F
A
T
E
---------------------
23
Fugue
53.29
15%
11
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
-
H
-----
M
L
C
A
R
F
L
G
G
-
A
W
------
K
T
-
V
-
P
L
E
H
L
R
I
S
R
I
K
G
G
-
M
S
-
N
M
--
L
--
F
L
C
-
R
L
S
EVYPPIRNE
P
N
--
K
---------
V
L
L
R
V
Y
-
F
N
P
----
E
---
T
-
E
S
-
H
-
L
V
A
E
S
V
I
F
T
L
L
S
-
E
R
-
H
L
-
G
-
P
K
L
Y
G
I
F
S
G
------------------
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
-
I
S
L
-
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
----------
Q
L
E
--
V
P
-------
I
W
K
E
---
P
--
D
------------
Y
------
L
C
----
E
A
L
------------
Q
R
-
W
----------
L
K
-
Q
----
L
--------------
T
G
-----------------
T
--
V
D
--------
A
---------
E
-------
H
-----
R
F
------
D
L
PEECGVSSVN
C
L
D
-------
L
A
----------
R
E
L
E
F
L
R
---
A
-------
H
-----
I
S
---
L
---
S
K
------------
S
P
V
T
F
C
H
N
D
-----
L
Q
E
G
N
----
I
L
L
P
K
--
R
-----
L
--
V
L
I
D
F
E
Y
A
S
Y
N
Y
--
R
A
F
D
F
A
N
-
H
F
I
---
E
W
T
I
--
D
Y
--------------
D
----------------
I
DEAPF
Y
K
I
Q
TENFPE
N
--------------
D
Q
M
L
E
F
F
-
L
N
Y
L
R
E
--
Q
G
------
N
--------
T
R
E
-----
N
E
-
L
Y
K
-
K
S
E
D
L
V
-
Q
E
T
L
P
F
V
P
V
S
H
----
F
F
W
------
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
-----
K
Q
L
L
K
N
L
A
-----
32
HHSearch
51.73
15%
-28
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[8-275]
---------------------
F
Q
T
L
-
H
-----
P
D
T
I
M
D
A
L
F
-
E
H
------
G
I
-
R
-
V
D
S
G
L
T
P
L
-
N
S
Y
E
-
N
R
-
V
Y
--
Q
--
F
Q
D
-
E
D----------
R
R
--
R
---------
F
V
V
K
F
Y
-
R
P
E
RW--
T
---
A
-
D
Q
-
I
-
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
-
V
P
-
V
-
A
A
P
V
A
F
-
N
G
Q
T
----
L
L
N
H
----
Q
G
F
Y
F
A
V
F
P
S
V
G
G
R
Q
F
E
A
---
D
-
N
-
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
------
Q
T
--
G
R
K
--
Q
L
-------
F
I
H
R
---
P
--
T
------------
I
------
G
L
----
N
E
Y
------------
L
I
-
E
----------
P
R
-
K
----
L
--------------
F
E
-----------------
D
--
A
T
--------
L
---------
I
-------
P
-----
S
G
------
L
-----------
K
A
A
-------
F
L
----------
K
A
T
D
E
L
I
---
A
-------
A
-----
V
T
---
A
H
WR
E
D
------------
F
T
V
L
R
L
H
G
D
-----
C
H
A
G
N
----
I
L
W
R
D
---------
G
P
M
F
V
D
L
D
D
A
R
N
G
P
--
A
V
Q
D
L
W
M
-
L
L
N
---
G
D
K
A
-----------------------------------
E
---------------
Q
--------------
R
M
Q
L
E
T
I
-
I
E
A
Y
E
E
--
F
S
------
E
--------
F
D
T
-----
A
E
-
I
G
L
-
I
E
P
L
R
A
-
M
R
L
V
---------------------------------------------------------------------
16
Fugue
49.93
15%
-11
- C3 -
-
3JR1
3
?
A:
[14-309]
-------------------
N
L
Y
F
Q
G
M
W
-----
K
S
I
S
Q
V
L
A
E
-
Q
F
------
G
A
-
Y
-
Y
F
I
K
H
K
E
K
L
Y
S
G
E
M
N
E
-
I
W
--
L
--
I
N
D
-
E
-----------
V
Q
--
T
---------
V
F
V
K
I
N
-
E
-
R
----
S
---
Y
-
R
S
M
F
-
R
A
E
A
D
Q
L
A
L
L
A
K
-
T
N
-
S
I
-
N
-
V
P
L
V
Y
G
I
------------------
G
N
S
Q
G
H
S
F
L
L
L
E
A
L
N
K
S
K
-
N
-
K
-
Q
S
S
F
T
I
F
A
-
E
K
I
A
Q
L
H
------
Q
I
--
Q
G
P
DK
Y
G
-------
L
D
F
D
---
T
--
W
------------
L
------
G
P
----
I
Y
Q
P
N
D
W
Q-------
T
S
-
W
----------
A
K
-
F
----
F
--------------
S
E
-----------------
N
--
R
I
--------
G
---------
W
-------
Q
-----
L
Q
------
I
-----------
C
K
E
K
GLIFGN
I
D
----------
L
I
V
Q
I
V
A
---
D
-------
T
-----
L
S
---
K
---
H
N
------------
P
K
P
S
I
L
H
G
N
-----
L
W
I
E
N
----
C
I
Q
V
D
--
D
-----
K
I
F
V
C
---
N
P
A
C
Y
W
G
D-
R
E
C
D
I
A
F
-
S
---------------------------
S
----------------
L
---------------
F
--------------
E
P
F
P
T
N
F
-
Y
Q
R
Y
N
E
--
I
Y
------
P
--------
L
E
E
-----
G
Y
-
L
E
R
-
K
L
I
Y
Q
L
-
Y
Y
L
L
N
F
S
Y
R
Y
Y
----
N
K
K
------
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
-
H
K
-------------------------------
25
Fugue
49.75
14%
-4
- C3 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
-----------------K
T
P
L
Y
E
T
L
-
N
-----
E
S
S
A
V
A
L
A
V
-
K
L
------
G
------
L
T
L
T
C
Q
E
I
G
D
G
-
N
L
-
N
Y
--
V
--
F
H
I
-
Y
-----------
D
R
--
A
---------
L
I
I
K
Q
A
-
V
P
Y
WPL-
T
---
I
-
D
R
-
A
-
R
I
E
S
S
A
L
I
R
Q
G
E
-
H
--
V
P
-
H
-
L
V
P
R
V
F
Y
S
D
T
E
MA
V
T
V
M
E
D
----
L
S
H
L
K
I
A
R
K
G
L
I
E
G
E
-
N
Y
P
H
-
L
-
S
-
Q
H
I
G
E
F
L
G
-
K
T
L
F
Y
S
S
------
D
Y
AL
E
P
K
--
V
K
-------
K
Q
L
V
---
K
--
Q
------------
F
------
T
N
----
P
E
L
------------
C
D
-
I
----------
T
E
-
R
----
L
VFTDPFFDHDT
N
D
F
E
E
-----------------
E
--
L
R
--------
P
---------
F
-------
V
-----
E
K
------
L
-----------
W
N
N
-------
D
S
----------
V
K
I
E
A
A
K
---
L
-------
K
-----
K
S
---
F
---
L
T
------------
S
A
E
T
L
I
H
G
D
-----
L
H
T
G
S
----
I
-
F
A
S
--
E
-----
H
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
--
I
G
F
D
V
G
Q
-
F
I
A
---
N
L
F
L
--
N
A
--------------
L
S
R
DGADR
E
P
L
Y
E
H
V
N
Q
V
---------------
W
--------------
E
T
F
E
E
T
F
-
S
E
A
W
Q
K
--
D
S
------
L
DVYANIDG
Y
L
T
-----
D
T
-
L
S
H
-
I
F
E
E
A
I
-
G
F
A
G
C
E
L
I
R
R
T
IGLA
H
V
A
------
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
-
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
EFKT
I
T
D
V
I
E
L
F
K
L
L
V
K-
13
Fugue
48.81
12%
11
- C3 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
-----------------L
S
A
E
D
A
K
K
-
L
-----
T
E
L
A
E
N
V
L
Q
-
G
W
------
D
V
---
Q
A
E
K
I
D
V
I
Q
-----
A
L
-
V
W
--
K
--
V
H
T
-
D
-----------
S
G
--
A
---------
V
C
L
K
R
I
-
H
-
R
----
P
---
E
-
K
K
-
A
-
L
F
S
I
F
A
Q
D
Y
L
A
K
-
K
G
M
N
V
---
P
G
I
L
P
N
K
K
G
S
L
----
Y
S
K
H
----
G
S
F
L
F
V
V
Y
D
W
I
E
G
R
P
F
E
L
T
------
V
K
Q
D
L
E
F
I
M
K
G
L
A
D
F
H
------
T
A
--
S
V
G
--
Y
Q
-------
P
P
N
G
---
V
--
P
I
F
T
KLGR
W
P
N
H
Y
T
------
K
R
----
C
K
Q
M
-----------
E
T
-
W
----------
K
L
M
A
----
E
--------------
A
E
-----------------
K
--
E
D
--------
P
---------
F
-------
S
-----
Q
L
------
Y
-----------
L
Q
E
-------
I
D
----------
G
F
I
E
D
G
L
---
R
-------
I
-----
K
D
---
R
---
L
L
Q
ST
Y
V
P
W
T
E
Q
L
K
K
S
P
N
L
C
H
Q
D
-----
Y
G
T
G
N
----
T
L
L
G
E
--
N
-----
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
--
P
I
R
D
L
R
K
M
I
I
P
---
L
L
D
T
--
T
G
--------------
V
----------------
W
------------------------------
D
D
E
T
F
N
V
M
L
N
A
Y
E
S
--
R
A
------
P
--------
L
T
E
-----
E
Q
-
K
Q
V
M
F
---
I
D
M
L
F
P
Y
E
L
Y
D
V
I
R
----
E
K
Y
------
V
R
K
S
A
L
P
K
E
E
L
E
S
A
F
-
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
-------------------
36
HHSearch
48.75
13%
-19
- C3 -
-
3I1A
4
?
B:
[4-286]
----------------------
Q
P
I
-
Q
-----
A
Q
Q
L
I
E
L
L
K
V
H
Y
------
G
I
---
D
I
H
T
A
Q
F
I
Q
G
G
A
D
-
T
N
-
A
F
--
A
Y
Q
A
D
S
-
E
-----------
S
K
--
S
---------
Y
F
I
K
L
K
-
Y
G
Y
--------
H
----
D
-
E
I
N
L
S
I
I
R
L
L
H
D
-
S
G
-
I
K
E
I
-
I
F
P
I
H
T
L
E
A
K
L
----
F
Q
Q
L
----
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
N
G
F
T
Q
N
-
L
-
T
-
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
H
------
E
T
--
S
V
P
--
I
S
-------
I
Q
Q
Q
---
L
RK
E
------------
I
------
Y
S
----
P
K
W
------------
R
E
-
I
----------
V
R
-
S
----
F
--------------
Y
N
-----------------
Q
--
I
E
FDNSDD--
K
L
T
A
A
F
K
S
--
F
-------
F
-----
N
Q
------
N
-----------
S
A
A
-------
I
H
----------
R
L
V
D
T
S
E
K
L
S
K
-------
K
-----
I
Q
---
P
---
D
L
------------
D
K
Y
V
L
C
H
S
D
-----
I
H
A
G
N
----
V
L
V
G
N
--
E
-----
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
--
K
E
R
D
L
M
F
-
I
G
G
---
G
V
G
N
--
V
W
-------------------------------
N
---------------
K
--------------
P
H
E
I
Q
Y
F
-
Y
E
G
Y
G
E
--
I
N
------
V
-----------------
D
-
K
T
I
-
L
S
Y
Y
R
H
-
E
R
I
V
---------------------------------------------------------------------
44
HHSearch
47.68
15%
-8
- C3 -
-
1NW1
-
CKA2_CAEEL
B:
[75-396]
--------------------------------------------------------
H
L
R
I
S
R
I
K
G
G
M
S
-
N
M
-
L
F
--
L
--
C
R
L
-
S
EVYPPIRNE--
P
N
--
K
---------
V
L
L
R
V
Y
-
F
N
P
E---
T
---
E
-
S
H
-
L
-
V
A
E
S
V
I
F
T
L
L
S
E
-
R
H
-
L
G
---
P
K
L
Y
G
I
F
S
------------------
G
G
R
L
E
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
-
L
-
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
------
Q
L
--
E
V
P
--
I
W
-------
K
E
P
D
---
Y
L
-
C
------------
E
------
A
L
----
Q
R
W
------------
L
K
-
Q
----------
L
T
-
G
----
T
--------------
V
D
-----------------
A
--
E
H
R
F
------
D
---------
L
-------
P
-----
E
E
CGVSSV
N
-----------
C
L
D
-------
L
A
----------
R
E
L
E
F
L
R
---
A
-------
H
-----
I
S
---
L
---
S
K
------------
S
P
V
T
F
C
H
N
D
-----
L
Q
E
G
N
----
I
L
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
--
R
A
F
D
F
A
N
-
H
F
I
---
E
W
T
I
--
D
Y
DIDEAPF
Y
K
I
Q
TEN
F
----------------
P
---------------
E
--------------
N
D
Q
M
L
E
F
-
F
L
N
Y
L
R
--
E
Q
------
G
--------
N
T
R
ENE
L
Y
K
K
S
E
D
L
-
V
Q
E
T
L
P
-
F
V
P
V
S
H
F
F
W
G
V
----
W
G
L
------
L
Q
V
E
---------------------------------------------
48
SP3
47.66
12%
-31
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
------------------------
G
-
S
-----
P
A
A
W
V
E
R
L
F
-
G
Y
--------------
D
W
A
Q
Q
T
I
G
C
S
-
D
A
A
V
F
--
R
--
L
S
A
-
Q
-----------
G
R
P
-
V
---------
L
F
V
K
T
D
-
L
S
G
----
A
---
L
-
N
E
-
L
-
Q
D
E
A
A
R
L
S
W
L
A
T
-
T
G
-
V
P
-
C
-
A
A
V
L
D
V
V
T
----------
E
----
A
G
R
D
W
L
L
L
G
E
V
P
G
Q
D
L
L
S
S
H
-
L
-
A
P
A
E
K
V
S
I
M
A
-
D
A
M
R
R
L
H
------
T
L
D-
P
A
T
--
C
P
-------
F
D
H
Q
---
A
--
K
------------
H
------
R
I
----
E
R
A
------------
R
T
-
R
----------
M
E
-
A
----
G
--------------
L
V
-----------------
D
--
Q
D
--------
D
---------
L
-------
D
-----
E
E
------
H
-----------
Q
G
L
-------
A
P
----------
A
E
L
F
A
R
L
---
K
-------
A
-----
R
M
---
P
---
D
G
------------
E
D
L
V
V
T
H
G
D
-----
A
C
L
P
N
----
I
M
V
E
N
--
G
-----
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
--
R
Y
Q
D
I
A
L
-
A
T
R
---
D
I
A
----
E
--------------
E
----------------
L
---------------
G
--------------
G
E
W
A
D
R
F
-
L
V
L
Y
G
I
--
A
A
------
P
---------
D
S
-----
Q
R
-
I
A
F
-
Y
R
L
L
D
E
-
F
F
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