@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q5F561_NEIG1_: (2019-02-05 )
MSVYTSVSDDEMRGFLSGYDLGEFVSLQGIAQGITNSNYFLTTTSGRYVLTVFEVLKQEELPFFLELNRHLSMKGVAVAAPVARKDGRLDSVLAGKPACLVACLKGSDTALPTAEQCFHTGAMLAKMHLAAADFPLEMENPRYDAWWTEACARLLPVLSQDDAALLCSEIDALKDNLGNHLPSGIIHADLFKDNVLLDGGQVSGFIDFYYACRGNFMYDLAIAVNDWARTADNKLDEALKKAFVGGYEGVRPLSAGEKAYFPTAQRAGCIRFWVSRLLDFHFPQAGEMTFIKDPNAFRNLLLSLD
Atome Classification :
(20 SA)
--------........-----.10........------20-.-.....-..30......-..40....-.-.-.---------..50.-.--...------------.---.-.60-......-..70..-.-...-..80------........90...----.--....100...---.-...----110----.-------------.---......120.......130....----------------------.---------.-.140.-----.---.---...---...---150-.---.-----..---.-------.----.------------.--------.--------------160-.--------------.---...-....-170.---------..----.------.------...-180.-...---...190.....----..--200--.........210.......220.....------------..230-----------.--------..------------....-.240.......--250----.------........260...--..-..270......----.280---.........290.......300.--------..-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------M
S
V
Y
TSV
S
-----
D
D
E
M
R
G
F
L
SGY------
D
L
-
G
-
E
F
V
S
L
-
Q
G
I
A
Q
GITNS-
N
Y
F
-
L
T
TT-S-G-
R
---------
Y
V
L
T
V
-
F
--
E
V
L
------------
K
---Q-EEL-
P
F
F
L
E
L
-
N
RHLSM-K-G
V
A
-
V
AAP------VARKDGRLDSVLA----G--K
P
A
C
L
V
A
C
LK---G-SDT----AL-----P-------------
T
---
A
E
Q
C
F
H
T
G
A
M
L
A
K
M
H
LAAADFPL----------------------E---------M-EN--P-----R---Y---
D
A
W
---
W
T
E
---
A
---
C
---
A
-----
R
L
---
L
-------
P
----V------------L--------S--------------Q---D--------------
D
---
A
A
L
-
L
C
S
E
-
I
D
-
A
---------
L
K
----
D
------
N
------
L
GN-HLPS-G
I
I
---
H
A
DLFKD
N
V
L
L----DG--G----QV
S
G
F
I
D
F
Y
Y
A
CRG
N
F
M
Y
D
L
A
I
A
VN
D
W
------------
A
R
TA------------
D
--------
N
K
------------
L
D
E
A
-
L
K
K
A
F
VGGYEG--V------R------PLSAGEKAYFP
T
A
Q--RA-
G
C
I
R
F
W
V
S
R
L
L
----
D
F-----HFPQAG
E
M
T
F
IKD
P
N
A
F
R
N
L
L
LS--------LD-----------------------------
23
HHSearch
90.83
38%
-97
- C1 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-307]
------------
T
D
I
T
-----
E
D
E
L
R
N
F
L
T
Q
Y
------
D
V
-
G
-
S
L
T
S
Y
-
K
G
I
A
E
---
N
S
-
N
F
L
-
L
H
T
T
-
K
-
D
-
P
---------
L
I
L
T
L
-
Y
--
E
K
-----------------
K
-
N
D
L
-
P
F
F
L
G
L
-
M
Q
H
L
A
A
-
K
-
G
L
S
-
C
P
L
P
------
L
P
R
K
D
G
E
L
L
G
E
L
S
----
G
--
R
P
A
A
L
I
S
F
L
E
---
G
-
M
W
L
----
R
K
-----
P
-------------
E
---
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
F
E
I
----------------------
K
---------
R
-
P
N
--
A
-----
L
---
S
---
V
D
G
---
W
K
V
---
L
---
W
---
D
-----
K
S
---
E
ERA----
D
----
E
------------
V
--------
E
--------------
K
---
G
--------------
L
---
R
E
E
-
I
R
P
E
-
I
D
-
Y
---------
L
A
----
A
------
H
------
W
P
K
-
D
L
P
A
-
G
V
I
---
H
A
D
L
F
Q
D
N
V
F
F
----
L
G
--
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
------------
C
F
E
K
------------
D
--------
G
A
------------
Y
N
V
T
-
K
G
K
A
L
L
E
G
Y
Q
S
--
V
------
R
------
P
L
S
E
A
E
L
E
A
L
P
L
L
S
--
R
G
-
S
A
L
R
F
F
L
T
R
L
Y
----
D
W
-----
L
T
T
P
A
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
---------------------------------------
1
PsiBlast_PDB
88.91
39%
-92
* C1 *
-
2PPQ
-
KHSE_AGRFC
A:
[5-298]
------------
T
D
I
T
-----
E
D
E
L
R
N
F
L
T
Q
Y
------
D
V
-
G
-
S
L
T
S
Y
-
K
G
I
A
E
---
N
S
-
N
F
L
-
L
H
T
T
-
K
-
D
-
P
---------
L
I
L
T
L
-
Y
--
E
K
-----------------
K
-
N
D
L
-
P
F
F
L
G
L
-
M
Q
H
L
A
A
-
K
-
G
L
S
-
C
P
L
P
------
L
P
R
K
D
G
E
L
L
G
E
L
S
----
G
--
R
P
A
A
L
I
S
F
L
E
---
G
-
M
W
L
----
R
K
-----
P
-------------
E
---
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
F
E
I
----------------------
K
---------
R
-
P
N
--
A
L----
S
---
V
---
D
G
W
K
V
L
W
D
K
---
S
---
E
---
E
-----
R
A
---
D
-------
E
----
V
---------------------
E
--------------
K
---
G
--------------
L
---
R
E
E
-
I
R
P
E
-
I
D
-
Y
---------
L
A
----
A
------
H
------
W
P
K
-
D
L
P
A
-
G
V
I
---
H
A
D
L
F
Q
D
N
V
F
F
----
L
G
--
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
------------
C
F
E
K
------------
D
--------
G
A
------------
Y
N
V
T
-
K
G
K
A
L
L
E
G
Y
Q
S
--
V
------
R
------
P
L
S
E
A
E
L
E
A
L
P
L
L
S
--
R
G
-
S
A
L
R
F
F
L
T
R
L
Y
----
D
W
-----
L
T
T
P
A
G
A
L
V
V
K
K
D
P
------------------------------------------------
44
Fugue
85.72
38%
-40
- C1 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
------------
T
D
I
T
-----
E
D
E
L
R
N
F
L
T
Q
Y
------
D
V
-
G
-
S
L
T
S
Y
-
K
G
I
A
E
---
N
S
-
N
F
L
-
L
H
T
T
-
K
-
D
-
P
---------
L
I
L
T
L
-
Y
--
E
--------------
K
---
K
-
N
D
L
-
P
F
F
L
G
L
M
Q
-
H
L
A
A
-
K
-
G
L
S
-
C
P
L
P
------
L
P
R
K
D
G
E
L
L
G
E
L
S
----
G
--
R
P
A
A
L
I
S
F
L
E
---
G
M
W
L
R
----
K
------
P
-------------
E
---
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
F
E
I
----------------------
K
---------
R
-
P
N
--
A
-----
L
---
S
---
V
D
G
---
W
K
V
---
L
---
W
---
D
-----
K
S
---
E
-------
E
----
R
------------
A
--------
D
--------------
E
---
V
--------------
E
KG
L
R
E
E
-
I
R
P
E
-
I
D
-
Y
---------
L
A
----
A
------
H
------
W
P
K
-
D
L
P
A
-
G
V
I
---
H
A
D
L
F
Q
D
N
V
F
F
----
L
G
--
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
------------
C
F
E
K
------------
D
--------
G
A
------------
Y
N
V
T
-
K
G
K
A
L
L
E
G
Y
Q
S
--
V
------
R
------
P
L
S
E
A
E
L
E
A
L
P
L
L
S
--
R
G
-
S
A
L
R
F
F
L
T
R
L
Y
----
D
W
-----
L
T
T
P
A
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
--------
H
R
T
IANVAEYGLA------------------
25
HHSearch
60.30
23%
-24
- C1 -
-
6EF6
2
?
A:
[27-307]
---------------
D
-----
V
T
I
A
Q
Q
A
L
T
H
Y
------
D
V
-
S
-
D
N
A
S
L
-
R
L
L
-
N
L
S
E
N
A
-
T
Y
L
-
V
E
D
G
-
E
-
H
-
Q
---------
S
I
L
R
V
-
H
--
R
Q
D
------------
Y
HQ-
P
-
H
E
I
-
E
S
E
L
D
W
-
L
A
A
L
R
T
D
S
-
D
V
T
-
V
P
T
V
------
V
P
A
R
D
G
R
R
V
V
T
V
D
P
A
DV
P
--
R
H
V
V
H
F
E
M
V
G
---
G
-
A
E
P
----
D
E
ES---
L
-------------
T
---
L
D
D
F
Q
T
L
G
R
I
T
A
S
L
H
E
H
S
Q
R
W
T
R
----------------------
P
---------
A
-
G
F
--
G
-----
R
-------
F
S
W
D--
W
E
H
---
C
---
L
GDT
P
-----
R
W
GRW
Q
-------
D
----
A
EG----------
V
--------
G
--------------
A
---
S
--------------
E
---
T
A
L
-
L
T
R
A
-
Q
D
-
L
---------
L
H
----
R
K
L
E
E
--
Y
------
G
S
G
-
P
D
R
Y
-
G
L
I
---
H
A
D
L
R
L
A
N
L
L
V
----
D
S
--
S
TPQ-
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
F
I
------------
E
H
D
-----------------------
P
------------
R
L
G
E
-
W
Q
E
S
W
V
A
G
Y
R
S
--
R
------
R
------
E
L
P
A
A
D
E
A
M
L
P
S
F
V
-----------------------------------------------------------------------------------------
48
Fugue
60.25
19%
-7
- C1 -
-
4OCV
2
?
A:
[24-378]
---------------
T
-----
N
E
A
L
F
D
V
A
S
H
F
------
A
L
E
G
-
T
V
D
S
I
-
E
P
Y
G
D
G
H
I
N
T
-
T
Y
L
-
V
T
T
D
-
G
-
P
-
R
---------
Y
I
L
Q
R
-
M
-----------------
N
---
T
-
G
I
F
-
P
D
T
V
N
L
-
M
R
N
V
E
L
-
V
-
T
S
T
-
L
K
A
Q
GKE
T
L
D
I
V
R
T
T
S
G
D
T
W
A
E
I
----
D
--
G
G
A
W
R
V
Y
K
F
I
EH
T
M
-
S
Y
N
----
L
V
-----
P
-------------
N
---
P
D
V
F
R
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
G
F
D
A
----------------------
N
QLTETIAHF
H
-
D
T
--
P
-----
H
---
R
---
F
E
D
---
F
K
K
---
A
---
L
---
A
A
DELG
R
A
---
A
-------
G
----
C
------------
G
--------
P
--------------
E
---
I
--------------
E
---
F
Y
L
-
S
H
A
D
Q
Y
A
-
V
---------
V
M
----
D
------
G
------
L
R
D
G
S
I
P
L
-
R
V
T
---
H
N
D
T
K
L
N
N
I
L
M
----
D
A
TT
G
----
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
------------
A
S
T
A
LEDERDLDK
V
H
F
S
--------
T
E
------------
L
F
R
A
-
Y
T
E
G
F
V
G
E
L
R
D
----------------
S
I
T
A
R
E
A
E
L
L
P
F
S
G
--
N
L
-
L
T
M
E
C
G
M
R
F
L
A
----
D
Y
L
E
GDV
Y
F
A
T
K
Y
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
--------
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T------------
24
HHSearch
59.10
18%
-77
- C1 -
-
2Q83
4
COTI_BACSU
A:
[22-303]
-----------------------
L
A
E
N
V
L
Q
G
W
------
D
V
---
Q
A
E
K
I
-
D
V
I
Q
----
A
L
-
V
W
K
-
V
H
T
D
-
S
-
G
-
A
---------
V
C
L
K
R
-
I
--
H
R
-------------
P
---
E
-
K
K
A
-
L
F
S
I
F
A
-
Q
D
Y
L
A
K
-
K
-
G
M
N
-
V
P
G
I
------
L
P
N
K
K
G
S
L
Y
S
K
H
G
----
S
--
F
L
F
V
V
Y
D
W
I
E
---
G
-
R
P
F
----
E
L
-----
T
-------------
V
---
K
Q
D
L
E
F
I
M
K
G
L
A
D
F
H
T
A
S
V
G
Y
Q
P
----------------------
P
---------
N
-
G
V
--
P
I
F
T
--
K
---
L
---
G
R
W
---
P
N
H
---
Y
T
K
R
C
---
K
-----
Q
M
---
E
-------
T
----
W
K
L
M
A
E
A
E
KED
P
-
F
--------
S
Q
L
Y
L
----------
Q
---
E
--------------
I
D
G
F
I
E
D
-
G
L
R
I
-
K
D
-
R
---------
L
L
----
Q
------
S
T
Y
V
P
W
T
E
Q
L
-
K
K
S
P
-
N
L
C
---
H
Q
D
Y
G
T
G
N
T
L
L
----
G
E
--
N
----
E
Q
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
L
------------
L
D
T
T
---------------------
G
V
------------
W
D
D
E
-
T
F
N
V
M
L
N
A
Y
E
S
--
R
------
A
------
P
L
T
E
E
Q
K
Q
V
M
F
I
D
M
-----------------------------------------------------------------------------------------
45
Fugue
57.10
16%
-10
- C1 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
-------S
A
F
T
F
Q
T
L
H
-----
P
D
T
I
M
D
A
L
F
E
H
------
G
I
-
R
-
V
D
S
G
L
-
T
P
L
-
N
S
Y
E
N
R
-
V
Y
Q
-
F
Q
D
E
-
D
-
R
R
R
---------
F
V
V
K
F
-
Y
RP
E
R
W
------------
T
---
A
-
D
Q
I
-
L
E
E
H
Q
F
-
A
L
Q
L
V
N
-
D
-
E
V
P
-
V
A
A
P
------
V
A
F
N
G
Q
T
L
-
L
N
H
Q
----
G
--
F
Y
F
A
V
F
P
S
V
G
---
G
-
R
Q
F
----
E
A
-----
D
-------------
N
---
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
K
Q
L
F
----------------------
I
---------
H
-
R
P
--
T
-----
I
---
G
---
L
N
E
---
Y
L
I
---
E
---
P
---
R
-----
K
L
---
F
E
D
ATLIP
S
----
G
------------
L
--------
K
--------------
A
---
A
--------------
F
---
L
K
A
-
T
D
E
L
-
I
A
-
A
---------
V
T
----
A
------
H
------
W
R
E
-
D
F
T
V
-
L
R
L
---
H
G
D
C
H
A
G
N
I
L
W
----
R
D
--
G
------
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
-------------------------------------
K
A
------------
E
Q
R
M
-
Q
L
E
T
I
I
E
A
Y
E
E
--
F
------
S
------
E
F
D
T
A
E
I
G
L
I
E
P
L
R
A
M
R
L
-
V
Y
Y
L
A
W
L
M
R
R
W
A---
D
P
-----
A
F
P
K
N
--
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
--------
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY------------
27
HHSearch
54.96
16%
-29
- C1 -
-
1ZYL
-
SRKA_ECOLI
A:
[8-271]
-----------
F
Q
T
L
H
-----
P
D
T
I
M
D
A
L
F
E
H
------
G
I
-
R
-
V
D
S
G
L
-
T
P
L
-
N
S
Y
E
N
R
-
V
Y
Q
-
F
Q
D
E
D
R
-
R
-
R
---------
F
V
V
K
F
-
Y
--
R
P
E
RW----------
T
---
A
-
D
Q
I
-
L
E
E
H
Q
F
-
A
L
Q
L
V
N
-
D
-
E
V
P
-
V
A
A
P
------
V
A
-
F
N
G
Q
T
L
L
N
H
Q
----
G
--
F
Y
F
A
V
F
P
S
V
G
---
G
-
R
Q
F
----
E
A
-----
D
-------------
N
---
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
K
Q
L
F
----------------------
I
---------
H
-
R
P
--
T
I----
G
---
L
---
N
E
Y
---
L
I
E
---
P
---
R
---
K
-----
L
F
---
E
D
A-----
T
----
L
------------
I
--------
P
--------------
S
---
G
--------------
L
---
K
A
A
-
F
L
K
A
-
T
D
-
E
L
I
A
A
-----
V
T
----
A
------
H
------
W
R
E
-
D
F
T
V
-
L
R
L
---
H
G
D
C
H
A
G
N
I
L
W
----
R
D
-------
G
-
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
------------
K
A
-------------------------------------
E
Q
R
M
-
Q
L
E
T
I
I
E
A
Y
E
E
--
F
------
S
------
E
F
D
T
A
E
I
G
L
I
E
P
L
R
--
A
--------------------------------------------------------------------------------------
28
HHSearch
54.67
17%
-14
- C1 -
-
4WH3
8
NAHK_BIFL2
A:
[4-297]
---------------
S
-----
N
E
V
L
F
G
I
A
S
H
F
------
A
L
E
G
-
A
V
T
G
I
-
E
P
Y
G
D
G
H
I
N
T
-
T
Y
L
-
V
T
T
D
-
G
-
P
-
R
---------
Y
I
L
Q
Q
-
M
--
N
T
S
------------
I
FPD
T
V
N
L
M
-
R
N
V
E
L
V
-
T
S
T
L
K
A
-
Q
-
G
K
E
-
T
L
D
I
------
V
P
T
T
S
G
A
T
W
A
E
I
D
----
G
--
G
A
W
R
V
Y
K
F
I
E
---
H
-
T
V
S
----
Y
N
LV---
P
-------------
N
---
P
D
V
F
R
E
A
G
S
A
F
G
D
F
Q
N
F
L
S
E
F
D
A
----------------------
S
---------
Q
-
L
T
--
E
-----
T
IA-
H
---
F
H
D
---
T
P
H
---
R
---
F
---
E
-----
D
F
---
K
-------
A
----
A
------------
L
A
A
DKLGRA
A
--------------
A
C
Q
-
P
--------------
E
---
I
D
F
-
Y
L
S
H
-
A
D
-
Q
---------
Y
A
V
V
M
D
G
------
L
------
R
D
G
-
S
I
P
L
-
R
V
T
---
H
N
D
T
K
L
N
N
I
L
M
----
D
A
TT
G
----
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
------------
A
S
T
A
------------
L
EDEKDLSK
V
H
------------
F
S
T
E
-
L
F
R
A
Y
T
E
G
F
V
G
E
L
R
------
G
------
S
I
T
A
R
E
A
E
L
L
P
F
S
G
--
N
--------------------------------------------------------------------------------------
26
HHSearch
50.52
17%
-14
- C1 -
-
4OCV
2
?
A:
[24-317]
---------------
T
-----
N
E
A
L
F
D
V
A
S
H
F
------
A
L
-
E
G
T
V
D
S
I
-
E
P
Y
G
D
G
H
I
N
T
-
T
Y
L
-
V
T
T
D
-
G
-
P
-
R
---------
Y
I
L
Q
R
-
M
--
N
T
G
------------
I
FPD
T
-
V
N
L
M
R
N
V
E
L
V
-
T
S
T
L
K
A
-
Q
-
G
K
E
-
T
L
D
I
------
V
R
T
T
S
G
D
T
W
A
E
I
D
----
G
--
G
A
W
R
V
Y
K
F
I
E
---
H
-
T
M
S
----
Y
N
LV---
P
-------------
N
---
P
D
V
F
R
E
A
G
R
A
F
G
D
F
Q
N
F
L
S
G
F
D
A
----------------------
N
---------
Q
-
L
T
--
E
-----
T
IAH
F
HD
T
P
H
R
---
F
E
D
---
F
---
K
---
K
-----
A
L
---
A
-------
A
DELG
R
------------
A
--------
A
GC------------
G
---
P
--------------
E
---
I
E
F
-
Y
L
S
H
-
A
D
-
Q
---------
Y
A
----
V
V
M
D
G
--
L
------
R
D
G
-
S
I
P
L
-
R
V
T
---
H
N
D
T
K
L
N
N
I
L
M
----
D
A
TT
G
----
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
------------
A
S
T
A
LEDERDLD----
K
--------
V
H
------------
F
S
T
E
-
L
F
R
A
Y
T
E
G
F
V
G
E
L
R
------
D
------
S
I
T
A
R
E
A
E
L
L
P
F
S
G
--
N
--------------------------------------------------------------------------------------
22
HHSearch
47.61
17%
-30
- C1 -
-
4PDY
1
?
A:
[23-300]
-----------------------
I
P
Q
A
V
V
S
K
Y
------
D
L
-
A
--
I
Q
Q
----
R
---
H
A
D
G
-
N
I
E
-
V
W
T
D
S
K
-
G
R
R
---------
Y
A
A
K
R
-
S
--
S
I
-------------
A
---
P
-
A
H
C
-
R
I
M
V
Q
C
-
L
R
H
A
Q
E
-
Q
-
G
F
T
K
F
A
R
F
------
V
T
T
S
S
N
A
P
Y
V
R
H
G
----
D
--
F
T
Y
Y
V
T
E
W
V
S
---
G
-
Q
P
A
----
N
F
-----
G
-------------
L
---
P
E
H
V
A
Q
T
A
Y
T
L
A
Q
F
H
E
A
T
R
S
F
R
T
----------------------
D
---------
W
-
K
-----------------
D
D
V
---
F
G
L
F
Q
A
R
---
W
---
R
-----
D
L
---
R
-------
Q
----
M
W
L
G
A
D
R
KREKD
A
F
--------
D
Q
L
L
L
S
M
R-------
D
---
E
--------------
L
---
H
R
D
-
A
A
E
S
-
L
A
-
L
---------
F
E
----
D
R
D
V
I
A
Y
L
------
E
A
E
-
R
S
S
G
-
G
W
C
---
H
L
D
V
I
P
S
N
C
L
Y
----
T
P
--
Q
----
H
Q
V
V
L
I
D
F
E
L
A
R
P
A
P
R
A
L
D
M
A
H
L
L
R
R
S
------------
L
E
R
----------------------
G
N
------------
W
D
G
H
-
L
A
Y
A
C
F
L
H
F
D
A
--
V
------
R
------
N
I
P
K
S
E
Y
R
A
V
E
A
I
L
--
R
--------------------------------------------------------------------------------------
62
SP3
47.30
15%
2
- C1 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
M
D
L
D
T
D
A
N
TI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGGAWK
T
V
-
P
L
E
H
L
R
I
-
S
R
I
K
G
G
M
S
N
M
-
L
F
L
-
C
R
L
S
-
E
-
V
-
Y
PPIRNEPN
K
V
L
L
R
V
-
Y
F-
N
P
E
------------
T
---
E
-
S
H
L
-
V
A
E
S
V
I
-
F
T
L
L
S
E
-
R
-
H
L
--
G
P
K
L
------
Y
G
I
F
S
G
----------------
G
R
L
E
E
Y
I
P
---
S
-
R
P
L
----
S
C
-----
H
E
I
S
----------
L
---
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
--
L
E
V
P
I
----------------------
W
---------
K
-
E
P
--
D
-----
Y
---
L
---
C
E
A
---
L
Q
R
---
W
---
L
---
K
-----
Q
L
---
T
-------
G
----
T
------------
V
--------
D
AE
H
R
F
D
L
PEECGVS
S
---
V
--------------
N
---
C
L
D
-
L
A
R
E
-
L
E
-
F
---------
L
R
----
A
------
H
------
I
S
L
S
K
S
P
V
-
T
F
C
---
H
N
D
L
Q
E
G
N
I
L
L
----
P
K
--
R
------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
------------
T
I
D
Y
------------
D
--------
I
D
EAPF
Y
K
I
Q
TENF
P
E
N
D
-
Q
M
L
E
F
F
L
N
Y
L
R
--
E
------
Q
GNTREN
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
--
P
F
-
V
P
V
S
H
F
F
W
G
V
W
----
G
L
-----
L
Q
V
E
L
S
P
V
G
F
--
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA--------------------------
31
HHSearch
43.43
17%
-38
- C1 -
-
5IGI
3
?
A:
[2-258]
---------
T
V
V
T
T
A
D
-----
T
S
Q
L
Y
A
L
A
A
R
H
------
G
L
-
K
-
L
H
G
P
L
-
T
V
N
E
L
G
L
D
Y
R
-
I
V
I
-
A
T
V
D
-
D
G
R
-
R
---------
W
V
L
R
I
-
P
--
R
R
A
------------
E
V
--
S
-
A
K
V
-
E
P
E
A
R
V
-
L
A
M
L
K
N
-
R
L
P
F
A
-
V
P
D
W
------
R
V
A
N
A
E
L
V
A
Y
P
M
-----
L
--
E
D
S
T
A
-
V
I
Q
P
---
G
-
S
S
T
----
P
D
WVVPQ
D
-------------
S
---
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
A
V
----------------------
D
---------
A
-
G
M
LI
R
-----
T
---
P
---
T
Q
A
R
Q
K
V
A
D
---
D
---
V
---
D
-----
R
V
---
R
-------
R
----
E
------------
F
--------
V
------------------
V
--------------
N
---
D
K
R
-
L
H
R
W
-
Q
R
-
W
---------
L
D
----
D
------
D
------
S
S
W
-
P
D
F
S
-
V
V
V
---
H
G
D
L
Y
V
G
H
V
L
I
----
D
N
T-
E
----
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
----------------------------------------------------
G
E
E
-
G
L
A
K
L
L
L
T
Y
E
A
--
A
------
G
------
G
R
V
----------------------------------------------------------------------------------------------------
34
HHSearch
43.04
17%
-37
- C1 -
-
5UXD
2
?
A:
[3-256]
------------
M
P
E
D
-----
L
D
A
L
L
D
L
A
A
R
H
------
G
L
-
D
L
D
G
G
T
L
-
R
T
E
E
I
G
L
D
F
R
-
V
A
F
-
A
R
A
H
-
D
G
G
-
D
---------
W
V
L
R
L
-
P
--
R
R
P
D-----------
V
---
L
-
E
R
A
-
A
V
E
G
R
L
-
L
A
M
L
A
P
H
L
-
D
V
A
-
V
P
D
W
------
R
I
S
T
----------------
S
E
L
I
A
Y
P
L
L
P
---
G
-
S
P
G
----
L
T
-----
V
A
ADG
E
V
S
W
HVDMA
S
---
T
V
Y
A
R
S
L
G
S
V
V
A
Q
L
H
A
V
D
A
E
A
A
A
----------------------
A
---------
T
-
G
I
--
E
V
R
S
P
A
Q
---
V
---
R
G
A
---
W
R
Q
---
D
---
L
---
A
-----
R
V
---
G
-------
A
----
E
------------
F
---------------------------
E
--------------
I
---
A
P
A
-
L
R
E
R
-
W
E
A
W
---------
L
A
----
D
------
D
------
G
C
W
-
P
G
H
S
-
V
L
T
---
H
G
E
L
Y
P
A
H
T
L
V
----
E
D
--
E
----
R
I
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
S
----------------------------------------------------
A
P
S
A
-
I
F
E
V
A
L
Q
A
Y
A
E
--
G
------
G
------
G
R
P
W
---------------------------------------------------------------------------------------------------
54
Fugue
42.77
14%
-9
- C1 -
-
3I1A
2
?
A:
[3-330]
-------K
Q
P
I
Q
A
Q
Q
L
-----
I
E
L
L
K
V
H
Y
-
G
I
------
D
I
-
H
-
T
A
Q
F
I
-
Q
G
G
A
D
T
-
N
A
F
-
A
Y
Q
-
A
D
S
E
-
S
-
K
-
S
---------
Y
F
I
K
L
-
K
--
Y
G
Y
------------
H
---
D
-
E
I
N
-
L
S
I
I
R
L
-
L
H
D
S
G
I
-
K
-
E
I
I
-
F
P
I
H
------
T
--
L
E
A
K
L
F
Q
Q
L
K
----
H
--
F
K
I
I
A
Y
P
F
I
H
---
A
-
P
N
G
----
F
T
-----
Q
N
L
-----------
T
---
G
K
Q
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
LRKEIYSP
K
W
R
E
I
V
R
S
F
Y
N
Q
---------
I
-
E
F
--
D
-----
N
---
S
---
D
D
K
---
L
T
A
---
A
---
F
---
K
-----
S
F
---
F
-------
N
----
Q
------------
N
--------
S
--------------
A
---
A
--------------
I
---
H
R
L
-
V
D
T
S
-
E
K
-
L
---------
S
K
----
K
------
I
------
Q
P
D
-
L
D
K
Y
-
V
L
C
---
H
S
D
I
H
A
G
N
V
L
V
----
G
N
--
E
----
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
G
G
G
---------------
V
G
------------
N
--------
V
W
------------
N
K
P
H
-
E
I
Q
Y
F
Y
E
G
Y
-
G
--
E
------
I
------
N
V
D
K
T
I
L
S
Y
Y
R
H
E
R
--
I
V
-
E
D
I
A
V
Y
G
Q
D
L
L
S
RNQ
N
N
-----
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
--------
F
A
T
E---------------------------
58
Fugue
42.62
13%
-2
- C1 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
---G
M
K
E
L
L
S
T
M
D
L
D
T
-----
D
A
N
T
I
P
E
L
K
E
R
------
A
H
-
M
-
L
C
A
R
F
L
G
G
A
W
K
T
V
P
L
E
-
H
L
R
-
I
S
R
I
-
K
-
G
-
G
---------
M
S
N
M
L
-
F
--
L
C
R
L
S
EVYPPIRNEP
N
---
K
-
V
L
L
-
R
V
Y
F
N
P
-
E
T
E
S
H
L
-
V
-
A
E
S
-
V
I
F
T
------
L
L
S
E
R
H
L
G
P
K
L
Y
G
----
I
--
F
S
G
G
R
L
E
E
Y
I
---
P
-
S
R
P
L
S
C
H
E
I
-----
S
-------------
L
---
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
--
Q
L
E
V
P
I
----------------------
W
---------
K
-
E
P
--
D
-----
Y
---
L
---
C
E
A
---
L
Q
R
---
W
---
L
---
K
-----
Q
L
---
T
-------
G
----
T
------------
V
--------
D
--------------
A
---
E
H
R
F
D
L
PEECGVSSV
N
---
C
L
D
-
L
A
R
E
-
L
E
-
F
---------
L
R
----
A
------
H
------
I
S
L
S
K
S
P
V
-
T
F
C
---
H
N
D
L
Q
E
G
N
I
L
L
----
P
K
--
R
------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
Q
T
------------
E
--------
N
F
------------
P
E
N
D
-
Q
M
L
E
F
F
L
N
Y
L
R
--
E
Q
GNTRE
N
------
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
--
P
F
-
V
P
V
S
H
F
F
W
G
V
W
----
G
L
-----
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
--------
F
K
H
K
Q
L
L
K
N
LA--------------------
59
Fugue
41.40
13%
-8
- C1 -
-
3CSV
11
?
A:
[4-333]
----------------------------
S
R
E
D
------
E
I
-
R
-
D
F
L
A
T
-
H
G
Y
A
D
W
N
R
T
P
-
R
Y
Q
-
R
L
R
S
-
P
-
T
-
G
---------
A
K
A
V
L
M
D
--
W
S
P
------------
E
---
E
G
G
D
T
-
Q
P
F
V
D
L
-
A
Q
Y
L
R
N
-
L
-
D
I
S
--
A
P
E
------
I
Y
A
E
E
H
A
R
G
L
L
L
I
----
E
D
L
G
D
A
L
F
T
E
V
I
N
---
N
-
D
P
A
----
Q
E
M
----
P
-------------
L
---
Y
R
A
A
V
D
L
L
I
H
L
H
D
A
Q
T
P
E
L
A
R
L
D
----------------------
P
---------
E
-
T
L
--
S
-----
E
M
--
T
---
R
L
A
---
F
S
E
---
Y
---
R
---
Y
-----
A
I
---
L
-------
G
----
D
------------
A
--------
A
--------------
E
---
D
--------------
N
---
R
K
R
-
F
E
H
R
-
F
A
-
Q
---------
I
L
----
S
------
A
------
Q
L
E
---
G
D
M
V
F
V
---
H
R
D
F
H
A
Q
N
L
L
W
LPER
E
G
--
L
----
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
D
A
------------
R
R
D
V
------------
P
--------
A
Q
------------
V
E
A
Q
M
I
D
H
Y
I
Q
A
T
--
G
--
V
------
D
------
E
S
H
F
R
S
A
Y
A
V
I
A
V
Q
--
R
N
M
R
I
L
G
I
F
A
R
L
S
Q
--------------
R
F
G
K
R
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
--------
G
L
A
HPALASA
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
29
HHSearch
41.32
16%
-12
- C1 -
-
3CSV
8
?
A:
[4-263]
--------------
S
R
-----
E
D
E
I
R
D
F
L
A
T
H
------
G
Y
---
A
D
W
N
R
-
T
P
---------
R
Y
Q
R
L
R
S
P
-
T
G
A
-
K
---------
A
V
L
M
D
-
W
--
S
P
E
------------
E
---
G
-
G
D
T
-
Q
P
F
V
D
L
-
A
Q
Y
L
R
N
-
L
-
D
I
S
-
A
P
E
I
------
Y
A
E
E
H
A
--------------
R
G
L
L
L
I
E
D
L
G
---
D
-
A
L
F
----
T
E
-----
V
I
N
N
DPAQ------
E
---
M
P
L
Y
R
A
A
V
D
L
L
I
H
L
H
D
A
Q
T
P
E
L
A
----------------------
R
---------
L
-
D
P
--
E
-----
T
---
L
---
S
E
M
---
T
R
L
---
A
---
F
---
S
-----
E
Y
---
R
-------
Y
A---
I
------------
L
--------
G
--------------
D
AA
E
D
--------------
N
---
R
K
R
-
F
E
H
R
-
F
A
-
Q
---------
I
L
----
S
-------------
A
Q
L
-
E
G
D
M
-
V
F
V
---
H
R
D
F
H
A
Q
N
L
L
W
----
L
P
--
E
REGL
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
D
A
------------
R
R
------------------------
D
------------
V
P
A
Q
-
V
E
A
Q
M
I
D
H
Y
I
Q
--
A
------
T
------
G
V
D
E
S
H
F
R
S
A
Y
A
-------------------------------------------------------------------------------------------
7
PsiBlast_PDB
40.27
22%
-68
- C1 -
-
1L8T
2
KKA3_ENTFL
A:
[37-224]
---------------------------------------------------------
N
E
-
N
L
Y
-
L
K
M
T
-
D
-
S
-
R
---------
Y
K
G
T
T
-
Y
--
D
V
E
------------
R
---
E
-
K
D
M
-
M
L
W
L
E
------
G
K
-
L
-
P
V
P
-
K
V
L
H
------
F
E
R
H
D
G
-
W
S
N
L
L
M
----
S
--
E
A
D
G
V
L
C
S
E
E
---
Y
-
E
D
E
----
Q
S
-----
P
-------------
E
---
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
-------------------------------------------------
Y
---
T
N
S
---
L
D
S
---
R
---
L
---
A
-----
E
L
---
D
-------
Y
----
L
------------
L
--------
N
--------------
N
---
D
--------------
L
---
A
D
V
-
D
C
E
N
-
W
E
-
E
DTPFKD
P
R
E
L
Y
----
D
------
F
------
L
K
T
-
E
K
P
E
-
E
E
L
V
FS
H
G
D
L
G
D
S
N
I
F
V
----
K
D
--
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
SP3
40.18
14%
-10
- C1 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
--------------
G
S
-----
P
A
A
W
V
E
R
L
F
G
Y
--------------
D
W
-
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
-
L
S
A
Q
-
G
-
R
P
V
---------
L
F
V
K
T
-
D
--
L
S
G
------------
A
---
L
-
N
E
L
-
Q
D
E
A
A
R
-
L
S
W
L
A
T
-
T
-
G
V
P
-
C
A
A
V
------
L
D
V
V
T
------
E
A
----
G
--
R
D
W
L
L
L
G
E
V
P
---
G
-
Q
D
L
----
L
S
-----
S
-------------
H
LA
P
A
E
K
V
S
I
M
A
D
A
M
R
R
L
H
----
T
L
D
P
----------------------
A
---------
T
C
P
F
--
D
-----
H
---
Q
---
A
K
H
---
R
I
E
---
R
---
A
---
R
-----
T
R
---
M
E
A
GLVDQ
D
----
D
------------
L
--------
D
--------------
E
---
E
--------------
H
---
Q
G
L
A
P
A
E
L
-
F
A
-
R
---------
L
K
----
A
------
R
------
M
P
D
-
G
E
D
L
-
V
V
T
---
H
G
D
A
C
L
P
N
I
M
V
----
E
N
--
G
----
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
------------
A
E
E
------------------------------------
L
G
G
E
-
W
A
D
R
F
L
V
L
Y
-
G
--
I
------
A
------
A
P
D
S
Q
R
I
A
F
Y
R
L
L
D
--
E
F
-
F
-----------------------------------------------------------------------------------