@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A6CIE6_9BACI: (2019-01-26 )
MNQAQFEKVIEVLFPDIIIQEVTAYEKGWDNDIFIVNKEIVFRFPRSEEVASKVKDEIILLKHLAHKEPKLDIPRYKGIEMDGNLKCVKYNFMKGKSLSEIKNSRLDLHSAELLGDFLSRLHSIELSALKETNITSFHTDTYWENLYESAKTYVFPNITHSERAEIQQFYEDFSNNPIYSNVNKAVIHGDLTAANILYNKEEECVSGIIDFTDAQIADPAFDFAGLYWAYGPEFTKKLLTYYDGKDKTGIFERVQSFYGLQPIFHELIYAVKENHDVDWGSALERFQYLNSHR
Atome Classification :
(31 SA)
---.........10...-.....20........30....--.---.----.-.40..-----......-50........60........--70.-...--..--.----.80-.----------.-....----..90...---......100------..--.---.----------.-...------.110--.........120------------.......130.....---...140.--..----...---.---150--....--.---------.---...160----.....---..------..170......---.180.......190.....--..200-.-.......210.......220.------...---.----.----.----------------230---.........240....---...250--.......260.......270--.....-----..280.......290.--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---M
N
Q
A
Q
F
E
K
V
I
E
V
L
F
-
P
D
I
I
I
Q
E
V
T
A
Y
EKGWDN
D
I
F
I
--V---
N
----
K
-
E
I
V
F
R-----FP
R
S
E
E
-
V
A
S
K
V
K
D
E
I
I
L
L
K
H
L
AHKEP--KLD-IPR--YK--G----IEM-D----------G-
N
L
K
C
----
V
K
Y
-NFM---KGK
S
L
S
E
--------
I
K
--
N
---S----------R-LDL------
H
S
----
A
E
L
L
G
D
F
L
S
R
L
H
------------
S
I
E
L
S
A
LK-ETNITS---FH
T
D
T
Y
W
--
E
N
----
L
Y
E
---
S
---
A
----
K
T
Y
V
--F---------P---NI
T
H
------
S
E
R
A
E
---
I
Q
------
Q
F
Y
E
DFSNNPI---YSNV
N
K
A
V
I
HGDLT
A
A
N
I
L--YN
K
E
--
E
-
E
C
V
S
G
I
I
DFTDAQIADP
A
F
D
F
------
A
G
L
---Y----W----A----------------Y-----
G
P
E
F
T
K
K
L
L
T
Y
YDGKD---K
T
G
I
F
E
--
R
V
Q
S
F
YG
L
Q
P
I
F
H
E
L
I
Y
A
V
K--ENHDV-----
D
W
G
S
A
L
E
R
F
Q
Y
L
NSHR--------------------------
4
PsiBlast_PDB
78.06
31%
-3
- C1 -
-
3TDW
1
?
A:
[4-287]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
-
P
D
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
--
V
---
N
----
G
-
D
W
V
F
R
-----
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
V
---
K
V
N
-
I
P
Q
--
Y
V
Y
I
G
----
K
R
S
-
D
----------
G
-
N
-
P
F
----
V
G
Y
-
R
K
V
---
Q
G
Q
I
L
G
E
--------
D
G
--
M
---
A
----------
V
-
L
P
D
------
D
A
----
K
D
R
L
A
L
Q
L
A
E
F
M
------------
N
-
E
L
S
A
F
P
V
E
T
A
I
S
A
---
G
V
P
V
T
N
L
--
K
N
K
I
L
L
L
S
E
---
A
---
V
----
E
D
Q
V
--
F
---------
P
---
L
L
D
E
------
S
L
R
D
Y
---
L
T
------
L
R
F
Q
S
Y
M
T
H
P
V
---
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
N
S
R
--
Q
-
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
------
V
Y
L
---
L
----
E
----
D
----------------
C
-----
G
E
L
F
T
R
Q
V
M
A
Y
R
G
E
V
D
---
L
D
T
H
I
R
--
K
V
S
L
F
V
----
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
-----
D
W
I
S
--------------------------------------
21
Blastp_CBE
77.73
31%
-0
- C1 -
-
3TDV
1
?
B:
[4-287]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
-
P
D
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
--
V
---
N
----
G
-
D
W
V
F
R
-----
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
V
---
K
V
N
-
I
P
Q
--
Y
V
YI
G
----
K
R
S
-
D
----------
G
-
N
-
P
F
----
V
G
Y
-
R
K
V
---
Q
G
Q
I
L
G
E
DGMAVFPD
D
A
--
K
---
D
----------
R
-
L
A
L
------
Q
L
----
A
E
F
M
N
---------------------
E
L
S
A
F
P
V
E
T
A
I
S
A
---
G
V
P
V
T
N
L
--
K
N
KILL
L
S
E
---
A
---
V
----
E
D
Q
V
--
F
---------
P
---
L
L
D
E
------
S
L
R
D
Y
---
L
T
------
L
R
F
Q
S
Y
M
T
H
P
V
---
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
TN
L
N
S
R
--
Q
-
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
------
V
Y
L
---
L
----
E
----
D
----------------
C
-----
G
E
L
F
T
R
Q
V
M
A
Y
R
G
E
V
D
---
L
D
T
H
I
R
--
K
V
S
L
F
V
----
T
F
D
Q
V
S
Y
L
L
E
GL
R
A
R
D
Q
-----
D
W
I
S
--------------------------------------
6
PsiBlast_PDB
77.57
31%
-5
- C1 -
-
3TDV
1
?
A:
[4-287]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
-
P
D
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
--
V
---
N
----
G
-
D
W
V
F
R
-----
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
V
---
K
V
N
-
I
P
Q
--
Y
V
Y
I
G
----
K
R
S
-
D
----------
G
-
N
-
P
F
----
V
G
Y
-
R
K
V
---
Q
G
Q
I
L
G
E
DGMAVFP
D
D
A
--
K
---
D
----------
R
-
L
A
L
------
Q
L
----
A
E
F
M
N
---------------------
E
L
S
A
F
P
V
E
T
A
I
S
A
---
G
V
P
V
T
N
L
--
K
N
K
I
L
L
L
S
E
---
A
---
V
----
E
D
Q
V
--
F
---------
P
---
L
L
D
E
------
S
L
R
D
Y
---
L
T
------
L
R
F
Q
S
Y
M
T
H
P
V
---
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
N
S
R
--
Q
-
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
------
V
Y
L
---
L
----
E
----
D
----------------
C
-----
G
E
L
F
T
R
Q
V
M
A
Y
R
G
E
V
D
---
L
D
T
H
I
R
--
K
V
S
L
F
V
----
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
-----
D
W
I
S
--------------------------------------
45
HHSearch
76.13
27%
-29
* C1 *
-
3TDW
1
?
A:
[4-298]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
-
P
D
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
--
V
---
N
----
G
-
D
W
V
F
R
-----
F
P
K
S
Q
Q
-
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
-
V
--
K
V
N
-
I
P
Q
--
Y
V
--
Y
----
I
G
K
R
S
----------
D
-
G
N
P
F
----
V
G
Y
-
R
K
V
---
Q
G
Q
I
L
G
E
--------
D
G
--
M
A
V
L
P
----------
D
D
A
K
D
------
R
L
----
A
L
Q
L
A
E
F
M
N
E
L
S
------------
A
F
P
V
E
T
A
I
-
S
A
G
V
P
-------
V
T
N
L
--
K
N
----
K
I
L
---
L
---
L
S
E
A
V
E
D
Q
V
--
F
---------
P
---
L
L
D
E
------
S
L
R
D
Y
---
L
T
------
L
R
F
Q
S
Y
M
T
H
P
V
---
Y
T
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
--
T
N
L
N
SR
Q
-
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
------
V
Y
L
---
L
----
E
----
D
----------------
C
-----
G
E
L
F
-
T
R
Q
V
M
A
Y
R
G
E
V
D--
L
D
T
H
I
R
--
K
V
-
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
R
--
A
R
D
Q
D
-----
W
I
S
E
G
L
E
L
L
E
E
D
K
A
----------------------------
46
HHSearch
73.98
27%
-28
- C- -
-
3N4U
-
?
A:
[4-299]
---
Y
T
F
D
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
-
L
--
P
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
S
ET-------
Y
-
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
N
LP-------
K
Q
S
Q
N
------
Q
A
----
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
-----
L
D
F
R
E
K
I
--
N
E
----
D
N
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
----
E
DDE-
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
--
K
Y
-
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
E
--
Y
G
Y
M
D
-----
W
Y
E
E
G
L
N
E
I
R
S
I
K
-----------------------------
14
PsiBlast_PDB
73.16
30%
-20
- C1 -
-
6CD7
-
?
A:
[9-288]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
22
Blastp_CBE
71.99
31%
-17
- C1 -
-
4DTB
1
?
B:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
Y
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
QNQA
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
KY
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
12
PsiBlast_PDB
71.85
30%
-19
- C1 -
-
4DT8
1
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
23
Blastp_CBE
71.16
31%
-25
- C1 -
-
4DTA
1
?
B:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
-
A
G
M
TKI
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
QNQA
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
KY
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
5
PsiBlast_PDB
71.16
30%
-16
- C1 -
-
4DTB
1
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
Y
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
16
PsiBlast_PDB
70.40
30%
-22
- C1 -
-
4DTA
1
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
-
A
G
M
T
K
I
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
13
PsiBlast_PDB
70.21
30%
-15
- C1 -
-
4DT9
1
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
V
V
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
11
PsiBlast_PDB
69.53
30%
-15
- C- -
-
3N4U
-
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
3
PsiBlast_PDB
68.42
30%
-17
- C1 -
-
5C4L
1
?
A:
[28-307]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
Q
I
S
G
K
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
A
G
F
T
---
K
I
K
G
V
P
L
--------
T
P
--
L
---
L
----------
L
-
N
N
L
P
K
Q
S
Q
N
Q
A
----
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
7
PsiBlast_PDB
68.00
29%
-24
- C1 -
-
3SG8
1
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
A
G
F
T
---
K
I
K
G
V
P
L
--------
T
P
--
L
---
L
----------
L
-
N
N
L
P
K
Q
S
Q
N
Q
A
----
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
2
PsiBlast_PDB
67.81
30%
-22
- C1 -
-
5C4K
1
?
A:
[28-307]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
Q
I
S
G
K
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
A
G
F
T
---
K
I
K
G
V
P
L
--------
T
P
--
L
---
L
----------
L
-
N
N
L
P
K
Q
S
Q
N
Q
A
----
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
8
PsiBlast_PDB
67.35
29%
-25
- C1 -
-
3SG9
1
?
A:
[8-287]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
A
G
F
T
---
K
I
K
G
V
P
L
--------
T
P
--
L
---
L
----------
L
-
N
N
L
P
K
Q
S
Q
N
Q
A
----
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
20
PsiBlast_PDB
67.19
29%
-12
- C1 -
-
4DFU
3
?
A:
[29-286]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
M
ED
D
----
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
--
K
Y
R
-----------------------------------------------------------------------
1
PsiBlast_PDB
67.11
30%
-22
- C1 -
-
4N57
1
?
A:
[28-307]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
Q
I
S
G
K
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
--
V
V
--
F
----
T
G
M
-
P
----------
S
-
E
T
Y
Q
----
M
S
F
A
G
F
T
---
K
I
K
G
V
P
L
--------
T
P
--
L
---
L
----------
L
-
N
N
L
P
K
Q
S
Q
N
Q
A
----
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
---
M
EDD-
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
---
F
E
K
I
I
Y
G
-
K
--
E
Y
G
Y
M
-----
D
W
----------------------------------------
49
HHSearch
65.51
20%
-11
- C1 -
-
5IQC
2
AACA_STAAU
A:
[11-302]
----
N
V
K
A
M
K
Y
L
I
E
H
Y
F
-
D
N
F
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
--
V
---
N
----
N
-
E
Y
I
F
K
-----
T
K
F
S
T
N
-
K
K
K
G
Y
A
K
E
K
A
I
Y
N
F
L
N
T
N
-
L
ET
N
V
K
-
I
P
N
--
I
E
--
Y
----
S
Y
I
-
S
----------
D
-
E
L
S
I
----
L
G
Y
-
K
E
I
---
K
G
T
F
L
T
P
--------
E
I
--
Y
---
S
T
MS-------
E
E
E
Q
N
------
L
L
----
K
R
D
I
A
S
F
L
R
Q
M
H
------------
G
L
D
Y
T
D
I
S
-
E
C
T
I
-----
D
N
K
Q
N
V
L
--
E
E
----
Y
-
I
---
L
---
L
----
R
E
T
I
--
Y
---------
N
---
D
L
T
D
------
I
E
K
D
Y
---
I
E
------
S
F
M
E
R
-
L
N
A
T
T
---
V
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
--
L
D
G
---
N
-
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
------
I
Y
L
---
L
----
E
DSEE
E
----------------
I
-----
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
D
---
I
E
K
A
K
E
--
Y
Q
-
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
--
N
I
K
Q
E
-----
F
I
E
N
G
R
K
E
I
Y
K
R
T
-----------------------------
48
HHSearch
64.09
20%
-11
- C1 -
-
5IQI
1
AACA_STAAU
C:
[11-302]
----
N
V
K
A
M
K
Y
L
I
E
H
Y
F
-
D
N
F
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
--
V
---
N
----
N
-
E
Y
I
F
K
-----
T
K
F
S
T
N
-
K
K
K
G
F
A
K
E
K
A
I
Y
N
F
L
N
T
N
-
L
ET
N
V
K
-
I
P
N
--
I
E
--
Y
----
S
Y
I
-
S
----------
D
-
E
L
S
I
----
L
G
Y
-
K
E
I
---
K
G
T
F
L
T
P
--------
E
I
--
Y
---
S
T
MS-------
E
E
E
Q
N
------
L
L
----
K
R
D
I
A
S
F
L
R
Q
M
H
------------
G
L
D
Y
T
D
I
S
-
E
C
T
I
-----
D
N
K
Q
N
V
L
--
E
E
----
Y
I
L
---
L
--------
R
E
T
I
--
Y
---------
N
---
D
L
T
D
------
I
E
K
D
Y
---
I
E
------
S
F
M
E
R
-
L
N
A
T
T
---
V
F
E
G
K
K
C
L
C
H
N
D
F
S
C
N
H
L
L
--
L
D
G
---
N
-
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
------
I
Y
L
---
L
----
E
----
D
SEEE------------
I
-----
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
D
---
I
E
K
A
K
E
--
Y
Q
-
D
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
--
N
I
K
Q
E
-----
F
I
E
N
G
R
K
E
I
Y
K
R
T
-----------------------------
19
PsiBlast_PDB
63.65
29%
-24
- C1 -
-
4DFB
1
?
A:
[29-286]
-------
Q
V
E
K
A
I
E
Q
L
Y
-
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
--
I
---
N
----
R
-
D
F
I
F
K
-----
F
P
K
H
S
R
-
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
---
L
P
-
I
P
E
VV
F
T
--
G
----
M
P
S
-
E
----------
T
Y
Q
M
S
F
----
A
G
F
-
T
K
I
---
K
G
V
P
L
T
P
--------
L
L
--
L
---
N
----------
N
-
L
P
K
------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
------------
S
I
N
I
S
G
F
K
-
S
N
L
V
L
D
---
F
R
E
K
I
N
E
--
D
N
------
K
---
K
---
I
----
K
K
L
L
--
S
---------
R
---
E
L
K
G
------
P
Q
M
K
K
---
V
D
------
D
F
Y
R
D
I
L
E
N
E
I
---
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
--
F
D
T
E
--
K
-
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
------
I
S
L
M
E------
E
----
E
----------------
Y
-----
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
---
I
P
T
V
L
E
--
K
Y
R
-----------------------------------------------------------------------
55
HHSearch
63.20
22%
-37
- C1 -
-
3HAM
3
?
A:
[6-292]
---------
A
E
I
Y
E
H
L
N
-
K
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
--
C
---
N
----
E
-
Q
Y
V
V
K
-----
V
P
K
R
D
S
-
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K
L
--
S
Y
Q
-
I
P
A
--
V
V
--
Y
----
Q
S
----------------
D
R
F
----
N
I
M
-
K
Y
I
---
K
G
E
R
I
T
Y
--------
E
Q
--
Y
H
K
L
S
----------
E
K
E
K
D
------
A
L
----
A
Y
D
E
A
T
F
L
K
E
L
H
------------
S
I
E
I
D
C
S
V
-
S
L
F
S
-----
D
A
L
V
N
K
K
--
D
K
----
F
L
Q
D
K
K
L
---
L
----
I
S
I
L
E
K
E
---------
Q
---
L
L
T
D
------
E
M
L
E
H
---
I
E
------
T
I
Y
E
N
I
L
N
N
A
V
---
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
--
F
R
N
-----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
------
L
C
L
---
L
----
D
----
C
STDD------------
F
-----
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A
---
P
E
V
A
E
R
--
K
A
-
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
--
R
K
D
R
E
-----
M
L
I
K
G
V
S
E
L
L
Q
T
------------------------------
66
Fugue
62.44
20%
-13
- C1 -
-
3HAM
3
?
A:
[1-299]
---
M
V
N
L
-
D
A
E
I
Y
E
H
L
N
-
K
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
--
C
---
N
----
E
-
Q
Y
V
V
K
-----
V
P
K
R
D
S
-
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
--
N
C
--
K
L
S
-
Y
Q
I
--
P
A
--
V
----
V
Y
Q
-
S
----------
D
-
R
F
N
I
----
M
K
Y
-
I
K
G
---
E
R
I
T
Y
E
Q
--------
Y
H
K
L
S
---
E
----------
K
-
E
K
D
------
A
L
----
A
Y
D
E
A
T
F
L
K
E
L
H
------------
S
I
E
I
D
C
S
V
-
S
L
F
S
D
A
---
L
V
N
K
K
D
K
--
F
L
----
Q
D
K
---
K
---
L
----
L
I
S
I
--
L
---------
E
K
E
Q
L
L
T
D
------
E
M
L
E
H
---
I
E
------
T
I
Y
E
N
I
L
N
N
A
V
---
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
--
F
R
N
N
-----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
------
L
C
L
---
L
DCST
D
----
D
----------------
F
-----
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A
---
P
E
V
A
E
R
--
K
A
E
L
-
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
--
R
K
D
R
E
-----
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
FIF-----------------------
52
HHSearch
61.87
20%
3
- C1 -
-
5IGI
3
?
A:
[8-298]
----
D
T
S
Q
L
Y
A
L
A
A
R
-
H
-
G
L
K
L
H
G
P
L
T
V
N
E
L
G
L
D
Y
R
I
V
I
--
A
---
T
V
DDG
R
-
R
W
V
L
R
-----
I
P
R
R
A
E
-
V
S
A
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
-
L
--
P
F
A
-
V
P
D
--
W
R
--
V
----
A
N
A
-
E
L
---------
V
-
A
Y
P
M
LEDS
T
A
--
V
I
Q
---
P
G
S
S
T
P
D
--------
W
V
--
V
---
P
----------
Q
-
D
S
E
------
V
F
----
A
E
S
F
A
T
A
L
A
A
L
H
------------
A
V
P
I
S
A
A
V
-
D
A
G
M
L
I
---
R
T
P
-
T
Q
A
--
R
Q
----
K
V
A
---
D
---
D
----
V
D
R
V
--
R
---------
R
---
E
F
V
V
-------
N
D
K
R
---
L
-------
H
R
W
Q
R
W
L
D
D
D
S
---
S
W
P
D
F
S
V
V
V
H
G
D
L
Y
V
G
H
V
L
--
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
------
A
A
H
---
L
----
M
----
V
----------------
F
-----
G
E
E
G
L
A
K
L
L
L
T
Y
E
A
A
G
G
R
V
W
P
R
L
A
H
--
H
I
-
A
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
L
D
--
S
G
N
E
E
-----
Y
L
A
A
A
K
A
Q
L
A
--------------------------------
56
HHSearch
61.53
22%
-16
- C1 -
-
4DCA
1
?
A:
[36-312]
-------------------
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
--
C
---
N
----
E
-
Q
Y
V
V
K
-----
V
P
K
R
D
S
-
V
R
I
S
Q
K
R
E
L
E
L
Y
R
F
L
E
N
C
K
L
--
S
Y
Q
-
I
P
A
--
V
V
--
Y
----
Q
S
----------------
D
R
F
----
N
I
M
-
K
Y
I
---
K
G
E
R
I
T
Y
--------
E
Q
--
Y
---
H
K
LS-------
E
K
E
K
D
------
A
L
----
A
Y
D
E
A
T
F
L
K
E
L
H
------------
S
I
E
I
D
C
S
V
-
S
L
F
S
-----
D
A
L
V
N
K
K
--
D
K
----
F
L
Q
---
D
K
K
L
L
----
I
S
I
L
--
E
K
E
-------
Q
---
L
L
T
D
------
E
M
L
E
H
---
I
E
------
T
I
Y
E
N
I
L
S
N
A
V
---
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
--
F
R
N
-----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
------
L
C
L
---
L
----
D
CSTD
D
----------------
F
-----
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A
---
P
E
V
A
E
R
--
K
A
-
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
--
R
K
D
R
E
M
----
L
I
K
D
V
S
E
L
L
Q
--------------------------------
54
HHSearch
58.80
18%
15
- C1 -
-
5IWU
2
?
A:
[4-299]
----
D
I
K
Q
V
I
E
I
A
K
K
H
N
-
L
F
L
K
E
E
T
I
Q
F
N
E
S
G
L
D
F
Q
A
V
F
--
A
---
Q
D
NN-
G
I
D
W
V
L
R
-----
L
P
R
R
E
D
-
V
M
P
R
T
K
V
E
K
Q
A
L
D
L
V
N
K
Y
A
I
--
S
F
Q
-
A
P
N
--
W
I
--
I
----
Y
T
----------------
E
E
L
----
I
A
Y
-
K
K
L
---
D
G
V
P
A
G
T
--------
I
D
--
H
---
N
IGNYIWEIDI
N
N
V
P
E
------
L
F
----
H
K
S
L
G
R
V
L
A
E
L
H
------------
S
I
P
S
N
K
A
A
-
A
L
D
L
V
V
H
T
P
E
E
A
R
M
S
M
--
K
Q
----
R
M
D
---
A
---
V
----
R
A
------------------
K
F
G
--------
V
G
E
N
---
L
W
------
N
R
W
Q
A
W
L
N
D
D
D
---
M
W
P
K
K
T
G
L
I
H
G
D
V
H
A
G
H
T
M
--
I
D
K
---
D
-
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
------
I
F
N
---
Y
----
R
----
A
----------------
F
-----
G
E
E
G
L
E
A
L
I
L
A
Y
K
E
I
G
GYY
W
P
K
M
K
E
--
H
I
-
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
--
S
G
I
E
E
-----
Y
E
Q
M
A
K
E
A
L
E
V
-------------------------------
81
Fugue
49.41
18%
8
- C1 -
-
4OCV
2
?
A:
[24-378]
----
T
N
E
A
L
F
D
V
A
S
H
F
A
-
L
E
G
T
V
D
S
I
E
P
Y
G
D
G
H
I
N
T
T
Y
L
--
V
---
T
T
D
G
P
R
-
Y
I
L
Q
R
MNTGI
F
P
D
T
V
N
-
L
M
R
N
V
E
L
V
T
S
T
L
K
A
--
Q
G
K
E
--
T
L
D
-
I
V
R
--
T
T
--
S
GDTW
A
E
I
-
D
----------
G
-
G
A
W
R
----
V
Y
K
-
F
I
E
---
H
T
M
S
Y
N
L
--------
V
P
--
N
---
P
----------
D
-
V
F
R
------
E
A
----
G
R
A
F
G
D
F
Q
N
F
L
S
------------
G
F
D
A
N
Q
L
T
-
E
T
-
I
A
H
---
F
H
D
T
P
H
R
--
F
E
----
D
F
K
---
K
---
A
----
L
A
A
D
--
E
---------
L
---
G
R
A
A
------
G
C
G
P
E
---
I
E
F
Y
L
S
H
A
D
Q
Y
A
V
V
M
D
G
L
R
---
D
G
S
I
P
L
R
V
T
H
N
D
T
K
L
N
N
I
L
--
M
D
A
T
--
T
-
G
K
A
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
------
G
D
S
---
I
----
R
----
F
GASTALEDERDLDK
V
H
F
-----
S
T
E
L
F
R
A
Y
T
E
G
F
V
G
E
L
---
R
D
S
I
T
A
--
R
E
A
E
L
L
P
F
S
G
N
L
L
T
M
E
C
G
M
R
--
F
L
A
D
Y
L
E
GDV
Y
F
A
T
K
Y
P
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T
62
HHSearch
44.21
15%
-1
- C1 -
-
6EF6
2
?
A:
[29-317]
-------
T
I
A
Q
Q
A
L
T
H
Y
-
D
V
S
D
N
A
S
L
R
L
L
-
N
L
S
E
N
A
T
Y
L
--
V
---
E
D
GE-
H
-
Q
S
I
L
R
-----
V
H
R
Q
D
Y
H
Q
P
H
E
I
E
S
E
L
D
W
L
A
A
L
R
T
D
-
S
--
D
V
T
-
V
P
T
--
V
V
--
P
----
A
R
D
-
G
RR
V
V
T
V
D
P
A
D
V
-
P
R
H
V
----
V
H
F
-
E
M
V
---
G
G
A
E
P
D
E
--------
E
S
--
L
-----------------
T
L
------
D
D
----
F
Q
T
L
G
R
I
T
A
S
L
H
------------
E
H
S
Q
R
W
T
R
-
P
A
G
F
-------
G
R
F
S
W
DW
E
H
----
C
L
G
DTP
R
---
W
----
G
R
W
Q
--
D
---------
A
E--
G
V
G
A
------
S
E
T
A
L
L
T
R
A
Q
------
D
L
L
H
R
K
L
E
E
Y
G
---
S
G
P
D
R
Y
G
L
I
H
A
D
L
R
L
A
N
L
L
--
V
D
S
S
--
T
P
Q
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
------
G
T
A
---
V
----
S
----
F
----------------
I
EHDPR
L
G
E
W
Q
E
S
W
V
A
G
Y
R
S
R
R
E
L
-
P
A
A
D
E
A
--
M
L
-
P
S
F
V
F
L
R
R
L
L
L
L
A
W
---------------------------------------------------------
61
HHSearch
43.99
15%
-1
- C1 -
-
3I1A
4
?
B:
[7-291]
----
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
-
G
-
I
D
I
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
A
---
D
S
ES-
K
-
S
Y
F
I
K
-----
L
K
Y
G
Y
H
-----
D
E
I
N
L
S
I
I
R
L
L
H
D
S
----
G
I
K
E
I
I
F
--
P
I
--
H
----
T
L
E
-
A
KL
F
Q
Q
L
----
K
-
H
F
K
I
----
I
A
Y
-
P
F
I
---
H
A
P
N
G
F
T
--------
Q
N
--
L
-----------------
T
G
------
K
Q
----
W
K
Q
L
G
K
V
L
R
Q
I
H
------------
E
T
S
V
P
I
S
I
-
Q
Q
Q
L
R
K
---
E
I
Y
S
P
K
W
--
R
E
----
I
V
R
---
S
---
F
----
Y
N
Q
I
--
E
FDNSDD
K
L
T
A
---
A
F
K
S
F
F
N
Q
N
S
A
A
I
H
R
---
L
V
------
D
T
S
E
K
L
S
K
K
I
Q
---
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
--
V
G
N
-----
E
E
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
------
M
F
I
---
G
----
G
----
G
----------------
V
GNVWN
K
P
H
E
I
Q
Y
F
Y
E
G
Y
G
E
I
N
---
V
--
D
K
T
--
I
L
-
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
---------------------------------------------------------
68
Fugue
39.21
17%
40
- C1 -
-
3I1A
2
?
A:
[3-330]
KQP
I
Q
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
I
D
I
H
T
A
Q
F
I
Q
G
G
A
D
T
N
A
F
A
Y
Q
--
A
D
S
E
S
----
K
-
S
Y
F
I
K
-----
L
K
Y
G
Y
H
--
D
E
I
N
L
S
I
I
R
L
L
H
D
S
G
I
K
E
I
--
I
F
P
-
I
H
T
--
L
E
--
A
-----
K
L
-
F
----------
Q
-
Q
L
K
H
----
F
K
I
-
I
A
Y
---
P
F
I
H
A
P
N
--------
G
F
--
T
---
Q
----------
N
-
L
T
G
------
K
Q
----
W
K
Q
L
G
K
V
L
R
Q
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
E
I
Y
S
P
K
-
W
R
E
I
V
R
---
S
F
Y
N
Q
I
E
--
F
D
----
N
S
D
---
D
---
K
----
L
T
A
A
--
F
---------
K
---
S
F
F
N
------
Q
N
S
A
A
---
I
H
------
R
L
V
D
T
S
E
K
L
S
K
K
IQ
P
D
L
D
K
Y
V
L
C
H
S
D
I
H
A
G
N
V
L
--
V
G
N
E
--
E
-
S
--
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
MFIGGG
V
G
N
---
V
----
W
----
N
----------------
K
-----
P
H
E
I
Q
Y
F
Y
E
G
Y
G
E
I
N
V
---
D
K
T
I
L
S
--
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
S
--
R
N
Q
N
-------
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
DPNN
V
V
E
I
A
F
A
T
E-------------