@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A5M7M3_STREE_: (2019-02-04 )
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSIKTKFDKITPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGSDEK
Atome Classification :
(20 SA)
-----------------------------------------.........10...------.--.----.----..20........30.....---------..---------.----------40--------.........50...--.....60...-.....70........80--........90....-.-...-100-.---.....---..110....---.------.-.120...--------------.---.----.-.--------130.......140.--------------.-------------.--------------.------------.----.-.---------150.......160----------------..------..---...170.......180.--....------..190.......200.......210.------.---------..------------------.------------------.-.220.......-----230----------..--------------.-----------.....240.......250......---.260--.-----.---......270.......280.......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------
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S------Q--
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----
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----
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LGGMTNQ
N
Y
L
AK---------TT---------N----------
K
---------
Q
Y
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F
F
GK
G
T
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K
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--
I
NRQDEK
Y
N
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-
E
L
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LGL
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DI--EAGI
K
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-
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LRG--------------E---F----A-
P
--------
F
E
E
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Y
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Q--------------I-------------P--------------Y------------A----
N
-
Y
---------
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L
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----------------
L
A
------
D
L---GVDRKS
C
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LV
P
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R
L
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L
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P
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------S---------EF------------------T------------------
S
-
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E
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YE-----SD-----------QT--------------P-----------VS
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EQ---G-----E---D
F
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D
Y
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N
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A
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L
A
SYGGSDEK---
1
PsiBlast_PDB
98.63
99%
-83
- C2 -
-
4R77
-
?
B:
[1-283]
-----------------------------------------
M
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------
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Y
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N
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Y
Q
R
A
V
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G
L
A
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Y
---------
3
PsiBlast_PDB
97.84
99%
-70
- C2 -
-
4R7B
-
?
A:
[21-304]
-----------------------------------------
M
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Q
--
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----
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----
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---
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-----
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--------------
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---
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---
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-----
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---
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D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
--------
2
PsiBlast_PDB
97.31
99%
-69
- C2 -
-
4R78
2
?
A:
[21-304]
-----------------------------------------
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--
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----------
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--
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Y
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A
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A
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Y
G
--------
21
HHSearch
86.19
97%
26
- C2 -
-
4R78
2
?
A:
[21-304]
-----------------------------------------
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Q-----
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----
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-
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---
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---
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-----
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D
Y
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V
N
R
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Q
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A
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L
A
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Y
G
--------
22
HHSearch
85.84
97%
28
- C2 -
-
4R7B
-
?
A:
[21-304]
-----------------------------------------
M
E
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Q-----
E
--
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----
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----
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-
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D
Y
G
V
N
R
Y
Q
R
A
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K
G
L
A
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G
--------
27
HHSearch
59.21
25%
-4
- C2 -
-
3DXQ
-
?
B:
[5-288]
--------------------------------------------
E
A
R
A
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--------------------------------
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---
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-
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----------------
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-
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A
Y
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-----
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-----------
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----------
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---
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NPV--
D
---
D
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Y
A
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---------
25
HHSearch
56.36
23%
21
- C2 -
-
2QG7
-
?
D:
[110-454]
--------------------------------------------------------------------------
S
L
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SK-------
Q
----------
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-----
N
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--
A
-
L
S
R
-
E
D
--
I
KN-
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
---
H
------
D
-
I
K
L
N
E
N
L
YKELQVTQKVPGTR
P
---
S
----
F
-
L
--------
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
--------------
R
-------------
K
--------------
K
ICSFDAKANILK
L
----
I
-
D
F--------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
K
------
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
--
N
T
V
G
------
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
------
Y
AGFNCDWDL
T
P
------------------
S
------------------
K
-
E
E
E
Y
H
F
I
M
H
Y
L
-----
G
T
-----------
D
D
--------------
E
ELIN-------
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
---
S
SD---
F
---
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
-----------
28
HHSearch
55.20
25%
-6
- C- -
-
3DXQ
-
?
A:
[5-288]
--------------------------------------------
E
A
R
A
K
L
A
A
I
P
M
------
L
--
A
----
G
----
Y
T
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
A
--------------------------------
G
---------
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
A
V
A
A
-
R
E
A
A
K
A
G
V
S
P
E
V
L
H
V
D
P
--
A
T
G
V
M
V
T
R
Y
I
A
G
A
Q
-
T
-
M
S
P
-
E
K
--
F
K
T
R
P
G
S
P
A
---
R
A
G
E
A
F
R
K
L
---
H
------
G
-
S
G
A
V
F
P
F
--------------
R
---
F
----
E
-
L
--------
F
A
M
I
D
D
Y
L
K
V
L
S
----------------
N
-------------
V
--------------
T
------------
L
----
P
-
A
G
Y
-------
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
A
------
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
--
D
T
G
-------
E
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
------
G
---------
K
F
------------------
N
------------------
A
-
N
Q
D
E
E
L
M
R
A
Y
F
-----
G
G
-----------
E
A
--------------
R
P
----------
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
---
L
A
N
---
D
NPV--
D
---
D
F
R
A
Y
A
D
G
R
F
A
R
C
K
A
L
M
E
T
P
---------
46
Fugue
53.14
21%
16
- C2 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VSNVFEN
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
K
D
L
V
N
------
P
--
N
----
E
----
V
D
S
L
E
F
Q
I
I
N
G
T
N
I
L
I
K
V
K
DM-------
S
K
---------
Q
----------
A
---------
K
Y
L
I
R
L
Y
G
P
-
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
-
C
I
L
Y
N
K
N
I
A
K
K
-
I
Y
V
F
F
--
T
N
G
R
I
E
E
F
M
D
G
Y
A
L
-
S
-
R
E
D
-
I
K
--
N
---
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
---
H
D
IKLN
E
N
-
L
Y
K
E
L
Q
V
--------------
T
---
Q
----
K
-
V
PGTRPSF
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
--------------
R
K
KICSFDAKA
N
I
L
K
--------------
L
------------
I
----
D
-
F
---------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
K
------
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
V
G
E
G
------
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
------
Y
AGFNCDWDL
T
P
------------------
S
------------------
K
-
E
E
E
Y
H
F
I
M
H
Y
L
GTDD-
E
E
-----------
L
I
--------------
N
-----------
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
---
S
-----
F
---
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
-------
26
HHSearch
52.02
23%
19
- C2 -
-
2QG7
-
?
E:
[110-454]
--------------------------------------------------------------------------
S
L
E
F
Q
I
I
N
G
-
I
T
N
I
L
I
K
V
K
---------
D
M
SK-------
Q
----------
A
---------
K
Y
L
I
R
L
Y
G
P
K
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
-
C
I
L
Y
N
K
N
I
A
K
K
I
Y
V
F
F
T
----
N
G
R
I
E
E
F
M
D
G
Y
--
A
-
L
S
R
-
E
D
--
I
KN-
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
---
H
------
D
-
I
K
L
N
E
N
L
YKELQVTQKVPGTR
P
---
S
----
F
-
L
--------
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
--------------
R
-------------
K
--------------
K
ICSFDAKANILK
L
----
I
-
D
F--------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
K
------
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
--
N
T
V
G
G-----
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
------
Y
AGFNCDWDL
T
P
------------------
S
------------------
K
-
E
E
E
Y
H
F
I
M
H
Y
L
-----
G
T
-----------
D
D
--------------
E
ELIN-------
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
---
S
SD---
F
---
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
-----------
61
SP3
50.57
19%
9
* C2 *
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
---------------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
GAWKTV
P
--
L
----
E
----
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
---------
L
S
---------
E
----------
V
YPPIRNEPN
K
V
L
L
R
V
Y
F
-
N
P
E
T
E
--
S
H
L
V
A
E
S
V
I
F
-
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
----
S
G
G
R
L
E
E
Y
I
P
S
R
P
L
S
-
C
H
E
-
I
S
--
L
---
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
---
H
------
Q
-
L
E
V
P
I
W
K
--------------
E
---
P
----
D
Y
L
--------
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
--------------
V
-------------
D
AE
H
R
F
D
L
PEECGVS
S
------------
V
----
N
-
C
---------
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
S
------
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
--
L
P
K
R
--------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
------
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-
D
Q
M
L
E
F
F
L
N
Y
L
-----
R
E
-----------
Q
G
NTRENE
L
Y
K
K
S
---
E
-----------
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
---
V
E
L
SPV
G
-----
F
---
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
----
K
N
LA-
4
PsiBlast_PDB
50.27
27%
2
- C- -
-
3DXQ
-
?
A:
[7-281]
----------------------------------------------
R
A
K
L
A
A
I
P
M
------
L
--
A
----
G
----
Y
T
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
A
G
-----------------------------------------
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
A
V
A
A
-
R
E
A
A
K
A
G
V
S
P
E
V
L
H
V
D
P
--
A
T
G
V
M
V
T
R
Y
I
A
G
A
Q
-
T
-
M
S
P
-
E
K
--
F
---
K
T
R
P
G
S
P
A
R
A
G
E
A
F
R
K
L
---
H
------
G
-
S
G
A
V
F
P
F
--------------
R
---
F
----
E
-
L
--------
F
A
M
I
D
D
Y
L
K
V
L
S
--NVT-----------
L
-------------
P
--------------
A
------------
G
----
Y
-
H
---------
D
V
V
R
E
A
G
-
G
V
R
S
A
----------------
L
A
------
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
--
D
T
G
E
-------
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
------
G
---------
K
F
------------------
N
------------------
A
N
Q
D
E
E
L
M
R
A
Y
F
G
-----
G
E
-----------
A
R
--------------
P
-----------
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
P
---
V
-----
D
---
D
F
R
A
Y
A
D
G
R
F
A
R
C
----------------
33
HHSearch
49.97
18%
14
- C2 -
-
5FUT
10
CHKA_HUMAN
A:
[11-377]
--------------------------------------------
R
A
Y
L
W
C
K
E
F
L
P
GA----
W
--
R
GLRE
D
----
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
---------
L
P
---------
D
TTATLGDEP-
R
---------
K
V
L
L
R
L
Y
G
------G
A
E
A
M
V
L
E
S
V
M
F
-
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
----
P
Q
G
R
L
E
Q
F
I
P
S
R
--
R
-
L
D
T
-
E
E
LS
L
---
P
D
I
S
A
---
E
I
A
E
K
M
A
T
F
---
H
------
G
-
M
K
M
P
F
N
K
--------------
E
---
P
K---
W
-
L
--------
F
G
T
M
E
K
Y
L
K
E
V
L
R
I
--------------
K
-------------
F
--------------
T
------------
E
E
S
R
I
K
K
L
H
K
L
L
S----
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
E
------
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
--
L
L
E
G
RENSEK
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
------
W
---------
M
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
------------------
K
-
K
Q
Q
L
H
F
I
S
S
Y
L
-----
P
A
-----------
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
----------
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
---
A
K
I
---
S
-----
S
IEF
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
--------
34
HHSearch
49.25
18%
13
- C2 -
-
5FTG
11
CHKA_HUMAN
A:
[11-377]
--------------------------------------------
R
A
Y
L
W
C
K
E
F
L
P
GA----
W
--
R
GLRE
D
----
E
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
---------
L
P
---------
D
TTATLGDEP-
R
---------
K
V
L
L
R
L
Y
G
--------
E
A
M
V
L
E
S
V
M
F
-
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
----
P
Q
G
R
L
E
Q
F
I
P
S
R
--
R
-
L
D
T
-
E
E
LS
L
---
P
D
I
S
A
---
E
I
A
E
K
M
A
T
F
---
H
------
G
-
M
K
M
P
F
N
K
--------------
E
---
P
K---
W
-
L
--------
F
G
T
M
E
K
Y
L
K
E
V
L
R
I
--------------
K
-------------
F
--------------
T
------------
E
E
S
R
I
K
K
L
H
K
L
L
S----
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
E
------
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
--
L
L
E
G
RENSEK
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
------
W
---------
M
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
------------------
K
-
K
Q
Q
L
H
F
I
S
S
Y
L
-----
P
A
-----------
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
----------
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
---
A
K
I
---
S
-----
S
IEF
G
Y
M
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
--------
32
HHSearch
48.97
17%
6
- C2 -
-
3MES
2
?
B:
[54-410]
---------------------------------------------
I
I
G
I
C
R
K
N
I
P
G-----
W
--
K
----
E
INES
Y
I
E
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
---------
I
V
---------
N
ELKH------
P
---------
R
I
L
F
R
I
Y
G
K
H
V
--
F
--
Y
D
S
K
V
E
L
D
V
F
-
R
Y
L
S
N
I
N
I
A
P
N
I
I
A
D
F
----
P
E
G
R
I
E
E
F
I
D
G
E
--
P
-
L
T
T
-
K
Q
--
L
Q
L-
T
H
I
C
V
---
E
V
A
K
N
M
G
S
L
---
H
------
I
-
I
N
S
K
R
A
D
--------------
F
PSR
F
DKEP
I
-
L
--------
F
K
R
I
Y
L
W
R
E
E
A
K
I
Q
--------------
V
-------------
S
K
NNQ----------
I
------------
D
----
K
-
E
L
Y
-------
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
------
S
P
---
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
L
L
--
Q
T
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
------
Y
---------
I
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
-
E
L
R
K
L
F
I
S
V
Y
L
-----
S
Q
-----------
T
L
--------------
Q
EQVMPSQ
Q
I
V
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-------SV-
E
-----
F
---
D
F
T
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
--------
53
Fugue
46.91
15%
4
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
------------------------------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
------
Q
--
Y
----
D
----
V
G
S
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
---------
T
T
---------
K
----------
D
---------
P
L
I
L
T
L
Y
E
K
K
-------
N
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
K
G
L
S
C
P
L
P
L
P
R
K
DG
E
L
L
G
E
L
S
G
R
P
A
A
L
I
-
S
F
L
E
G
M
W
L
--
R
---
K
P
E
A
K
---
H
C
R
E
V
G
K
A
L
A
A
M
H
------
L
-
A
S
E
G
F
E
I
--------------
K
---
R
----
P
-
N
--------
A
L
S
V
D
G
W
K
V
L
W
D
K
S
--------------
E
-------------
E
--------------
R
------------
A
----
D
-
E
VE-------
K
G
L
R
E
E
I
R
P
E
I
D
Y
----------------
L
A
------
A
H
WPK
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
--
F
L
G
D
------
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
WCFEKD
G
---------
A
Y
------------------
N
------------------
V
-
T
K
G
K
A
L
L
E
G
Y
Q
S
V
R
P
L
S
E
-----------
A
E
--------------
L
-----------
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
---
T
P
A
---
G
-----
A
---
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
GLA
24
HHSearch
45.30
21%
30
- C2 -
-
1NW1
-
CKA2_CAEEL
B:
[75-421]
--------------------------------------------------------------------------
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
---------
L
S
EVYPPIRNE
P
----------
N
---------
K
V
L
L
R
V
Y
F
N
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
F
-
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
----
S
G
G
R
L
E
E
Y
I
P
S
-
R
-
P
-
L
S
C
-
H
E
--
I
S
L-
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
---
H
------
Q
-
L
E
V
P
I
W
K
--------------
E
P--
D
----
Y
-
L
--------
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
--------------
V
-------------
D
--------------
A
E
H
R
F
D
-------
L
----
P
-
E
ECGVSSVN
C
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
S
------
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
--
L
P
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
------
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-
D
Q
M
L
E
F
F
L
N
Y
L
-----
R
E
-----------
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
---
V
E
L
---
S
PVG--
F
---
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
----------
23
HHSearch
45.29
21%
33
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[75-421]
--------------------------------------------------------------------------
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
---------
L
S
EVYPPIRNE
P
----------
N
---------
K
V
L
L
R
V
Y
F
N
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
F
-
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
----
S
G
G
R
L
E
E
Y
I
P
S
-
R
-
P
-
L
S
C
-
H
E
--
I
S
L-
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
---
H
------
Q
-
L
E
V
P
I
W
K
--------------
E
P--
D
----
Y
-
L
--------
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
--------------
V
-------------
D
--------------
A
E
H
R
F
D
-------
L
----
P
-
E
ECGVSSVN
C
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
S
------
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
--
L
P
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
------
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-
D
Q
M
L
E
F
F
L
N
Y
L
-----
R
E
-----------
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
---
V
E
L
---
S
PVG--
F
---
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
----------
48
Fugue
43.52
17%
42
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-----------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
------
T
VP
L
----
E
----
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
EVYPPIR
N
E
---------
P
----------
N
---------
K
V
L
L
R
V
Y
F
N
P
E
T
E
S
--
H
L
V
A
E
S
V
I
F
T
-
L
L
S
E
R
---
H
L
G
P
K
L
Y
G
I
--
F
S
G
G
R
L
E
E
Y
I
P
-
S
R
-
P
-
L
S
C
-
H
E
--
I
S
L-
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
---
H
------
Q
L
E
V
P
I
W
K
E
--------------
P
---
D
----
Y
-
L
--------
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
DAE
H
R
F
D
L
PEECG
V
-------------
S
--------------
S
------------
V
----
N
-
C
---------
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
S
------
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
--
L
P
K
R
--------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
------
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-
D
Q
M
L
E
F
F
L
N
Y
L
-----
R
E
Q
GNTRENE
L
Y
K
K
S
--------------
E
-----------
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
---
V
E
L
---
S
-----
P
VGF
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-----
29
HHSearch
43.24
20%
41
- C2 -
-
3C5I
3
?
D:
[35-360]
--------------------------------------------------------------------------
N
L
R
V
K
Q
I
L
--
L
T
N
Q
L
F
E
V
G
---------
L
K
---------
E
E
T
A
N
N
Y
NSIR
T
---------
R
V
L
F
R
I
Y
G
K
H
V
D
E
L
--
Y
N
T
I
S
E
F
E
V
Y
-
K
T
M
S
K
Y
K
I
A
P
Q
L
L
N
T
F
----
N
G
G
R
I
E
E
W
L
Y
G
D
--
P
-
L
R
I
-
D
D
L
K
N
---
P
T
I
L
I
---
G
I
A
N
V
L
G
K
F
---
H
------
T
-
L
S
R
K
R
H
L
--------------
P
EH-
W
DRTP
C
-
I
--------
F
K
M
M
E
K
W
K
N
Q
L
F
K
Y
--------------
K
-------------
N
IE------------
K
------------
Y
----
N
-
C
D
I
-------
H
K
Y
I
K
E
S
D
K
F
I
K
F
----------------
M
K
V
Y
S
KSD
N
L
---
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
--
N
T
N
-------
K
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
------
T
---------
S
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
-
E
N
R
K
L
F
I
T
A
Y
L
-----
S
N
-----------
Y
L
DKVV----------
P
T
P
K
L
I
D
-----
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
---
G
Y
Q
---
T
KSYNE
F
---
D
F
F
L
Y
A
E
Q
R
L
K
M
Y
D
D
Q
K
E
Y
L
I
--------