@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : G4D212_9FIRM: (2019-01-29 )
MKRKIIFFTKAPALNYGKSRLKNFLSAKDRYELSVFLIKDNLKVLEKSGYEFVVYFSGDIENLNFIDYEKIPQRGENLGDRMFNALKAELNSNDQVILLGSDLRGITLKLIESAFSGLNNSDCVIAPAEDGGYGLIGLRKPLDLFSNIVYSQSDVFEKTLQKATALDISIERLDTVRDIDEIIDLIKEELQTKDVEILGSGEYNLNYRFNKNFVCRINLGSQLHLGDEQITYEYNALKTLESSGVTPKPHYLKKNSTYIRKGFLVMDYLVGRPLNYDTDMSIAAYLLSRVHNLEFKDTDLIRVEQPFKAMFEECFEMYSVYKNSKIYNNSIGKYIEHFFDYVKELGIKDNISNPCIINTELNNRNFIINGNNSYIIDWEKPLIGEAEQDLAHFLVPTTTNWKTDKILSDSEIEKFIYKYEKYRKINRQKLKKYFAFNVLRGITWCSMAKVEYEASERILSNQDTYEKINKFLSEDYLKMLHKRFYEV
Atome Classification :
(20 SA)
---........---.10........20........30......-----..40........50.-.......60.--.-....----..-70..------.-.....80........90..-..----------------....100.......110.......120...-----.-...130.......140--.--.-......150-----.......160.......170-----------.....-....180......-.-190-----.......-..200.-----....-..---210-----------.-----........220----...-.....230.----......-240..---.--.-.--..250..--..-----..-.260---......---.270-...-----.--.------.-----.280-------------------.-----------.-.....290.---------.-------.....-300.------.--..-.------.---..310.-------.....-.320.---.----.---.----.-------.------------.--330.-..-------....340..------------..-------.-..350.......360.-----.....-.-370.----.--.---...-...380........390-.......400..----------..--..----------..410-.....-....420--.--------------...--...430-------........440-------.......-----450-----.......460.......470...-----....480.....---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MK
R
K
I
I
F
F
---TKAPALNY
G
K
S
R
L
K
N
F
L
SAKD
R
Y
E
L
S
V
F
L
-----IKD
N
L
K
V
L
EKSG
Y
E
F
-
V
V
Y
FSGDIEN--L-NFI
D
----
Y
E
-KIPQ------R-G
E
N
L
G
D
R
M
F
N
A
L
K
A
ELNSN-
D
Q
----------------
V
I
L
LGSDL
R
G
I
T
L
K
L
I
E
S
A
FSGLNNS
D
C
V
I
-----
A
-PAEDG
G
Y
G
L
IGLR
K
P
---
L
--
D
-
L
F
S
N
I
VYSQ-----
S
D
V
F
E
K
T
L
Q
K
ATAL
D
I
S
I
-------------
E
R
L
D
T
-
V
R
D
I
D
E
I
I
D
L
I
K
E
-
E
-L-------QTK
D
V
E
I
-
L
GSG
E
Y
-----
N
L
N
Y
-
R
F---N-------------K-----
N
F
V
C
R
INLG
S
-----
Q
L
H-LGD
E
Q
I
T
Y
E
----Y
N
A
L
K
T
-
L
E
SSG---V--T-P--KP
H
Y
LKK--NS-----
T
Y
-
I
R
K
G
---
F
L
V
M
D
Y
---
L
VGR-PLN-----Y--D------T-----
D
M
S
I
-------------------
A
-----------
A
-
Y
L
L
S
R
V
HNL---------E-------FKDT
D
-
L
-
I
R
------V--E
Q
-
P
------
F
---
K
A
M
F
E
E
-------
C
F
E
M
Y
-
S
V
YKN---S----K---I----Y-------N------------N--
S
I
G
K
-
Y
I
-------
E
H
F
F
D
Y
V
K
E------------LG-------I-KDNISN
P
C
I
I
N
T
ELNN-----
R
N
F
I
I
-N-G--N----
N
--
S
---
Y
I
I
-DWEK-PLIG
E
A
E
Q
D
L
A
H
-FLVPTTTNW-KT----------DK--IL----------
S
D
S
---
E
I
E
K
F
-
I
Y
K
Y
E
K
Y
--
R
--------------
K
I
N
--
R
Q
K
L
K
--------
K
Y
F
A
F
N
V
L
R
G
I
-------
T
W
C
S
M
A
K
-----
V
E
Y
-----
E
A
S
E
R
ILSNQ
D
T
Y
E
K
I
N
K
F
L
S
E
D
-----
Y
L
K
M
L
H
K
R
FYEV---
51
Fugue
65.81
18%
53
* C4 *
-
5SWB
6
?
A:
[17-470]
----
K
P
V
I
K
M
Y
Q
I
G
D
K
P
D
N
L
D
E
L
L
A
N
A
N
K
I
I
E
E
K
V
G
A
K
L
D
I
Q
Y
LGWGD
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
A
D
N
Y
I
V
N
--
A
-
Q
K
G
A
----
Y
A
-
D
L
T
E
------
L
-
Y
K
K
E
G
K
D
L
Y
K
A
L
--------
D
P
----------------
A
Y
I
K
G
N
T
V
N
G
K
I
Y
A
V
P
--------------------------------------------
V
A
A
N
V
A
S
S
Q
-----
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
---------------
G
V
T
S
-
Y
E
T
L
E
P
V
L
K
Q
I
K
E
-
K
----------
A
P
D
V
V
P
-
F
A
I
G
K
V
F
I
P
S
D
N
F
D
Y
-
P
V
---
A
-------------
N
-----
G
L
P
F
V
I
D
L
E
G
DTT
K
V
V
N
R
-
Y
E
V
P
R
F
K
E
H
----
L
K
T
L
H
K
-
F
Y
E
A
G
---
Y
--
I
-
P
--
K
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V
A
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--
T
S
-----
F
D
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L
Q
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F
V
R
E
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---
T
V
G
--
P
A
D
-----
Y
--
G
------
N
------------------------------------------
S
L
L
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R
V
A
N
K
---------
D
-------
I
Q
I
K
P
-
I
-
T
N
------
F
--
I
K
-
K
------
N
---
Q
T
T
Q
V
A
-------
N
F
V
I
S
-------------------------------
N
------------
N
--
S
--
K
-
N
K
-------
E
K
S
M
E
I
L
N
L
------------
L
N
-------
T
-
N
P
E
L
L
N
G
L
V
Y
G
P
E
--
G
-----
K
N
W
E
K
-
I
-
E
--
G
----
K
--
E
---
N
R
V
-
R
V
L
D
-
G
Y
K
G
N
--
T
H
M
G
G
-
W
N
T
G
N
N
W
I
L
-
Y
I
----------
N
E
--
N
V
----------
T
D
Q
---
Q
I
E
N
S
-
K
K
E
L
A
E
A
--
K
E
S
PALGFIFNTDNV
K
S
E
--
I
S
A
I
A
--------
N
T
M
Q
Q
F
D
T
A
I
N
-------
T
G
T
V
D
P
D
-----
K
A
I
-----
P
E
L
M
E
K
L
K
S
E
G
A
Y
E
K
V
L
N
E
M
Q
K
Q
-----
Y
D
E
F
L
K
N
K
K
L
E
----
57
Fugue
63.86
19%
5
- C4 -
-
5FI9
11
ASM_MOUSE
A:
[9-536]
----
K
L
N
L
T
C
P
---
A
C
K
V
L
F
T
A
L
N
H
G
L
K
K
E
P
N
V
A
R
V
G
S
V
A
I
K
I
-----
C
K
M
L
N
I
A
P
L
D
V
C
Q
S
A
-
V
H
L
F
E
D
D
V
V
E
--
V
-
W
T
R
S
----
V
L
-
S
P
S
E
------
A
C
G
L
L
L
G
S
S
C
F
S
T
W
N
I
S
L
P
S
V
-
P
K
PPPKPPSPPAPG
A
P
V
S
R
V
L
F
L
T
D
L
H
-
W
D
H
E
Y
L
E
G
T
D
P
Y
C
A
D
P
L
C
C
R
RGS
G
W
P
-
P
N
S
Q
K
G
A
G
F
W
G
E
Y
S
K
---
C
--
D
-
L
P
----
L
R
T
-----
L
E
S
L
L
K
G
L
G
P
A
G
P
F
E
M
V
Y
W
TGDIPAHDVWQQ
S
R
Q
D
Q
-
L
R
A
L
T
T
I
T
D
L
V
R
K
-
F
-
L
-------
G
P
V
P
V
Y
P
A
V
G
N
H
E
S
-----
T
P
V
N
-
G
F
---
P
-------------
P
-----
P
F
I
-
K
G
N
Q
S
S
-----
Q
W
L
-
Y
E
A
M
A
K
A
W
E
PWLP
A
D
A
L
H
T
-
L
R
I
G
G
F
Y
A
L
--
T
-
P
--
R
P
G
L
R
L
I
S
L
N
M
-----
N
F
C
S
R
E
N
---
F
W
L
L
I
N
STD
P
A
G
Q
-
L
Q
W
-----
L
--
V
------
E
-----
E
L
Q
A
-------------------
A
-----------
E
-
N
R
G
D
K
V
H
I
I
---------------------
G
-
H
-
I
P
------
P
--
G
H
-
C
------
L
---
K
S
W
S
W
N
-------
Y
Y
K
I
I
-
A
R
Y
E
N
TLA
G
----
Q
---
F
----
F
-------
G
------------
H
--
T
H
V
D
-
E
F
-------
E
I
F
Y
D
E
-
E
T
------------
L
S
-------
R
-
P
L
A
V
A
F
L
A
P
S
A
T
T
F
I
N
L
N
P
G
Y
R
V
Y
Q
I
-
D
-
G
--
N
YPGS
S
--
H
---
V
V
L
-
D
H
E
T
-
Y
I
L
N
L
T
Q
A
N
A
A
G
-
G
T
P
S
W
K
R
L
Y
-
R
A
----------
R
E
--
T
Y
----------
G
L
P
---
D
A
M
P
A
-
S
W
H
N
L
V
Y
--
R
--------------
M
R
D
--
D
E
Q
L
F
--------
Q
T
F
W
F
L
Y
H
K
G
H
PPSEPCG
T
P
C
R
L
A
T
-----
L
C
A
-----
Q
L
S
A
R
----
A
D
S
P
A
L
C
R
H
L
M
-----------------------
22
HHSearch
63.02
28%
-32
- C7 -
-
3CGX
1
?
A:
[3-202]
---
S
E
S
C
I
L
F
F
---
V
K
Y
P
E
P
G
K
V
K
T
R
L
G
E
V
V
G
N
D
K
A
A
M
L
Y
R
H
F
-----
V
Q
D
M
L
Q
G
L
A
R
L
H
A
D
L
-
H
I
C
Y
V
P
G
D
A
D
L
P
E
-
K
F
K
A
W
LGP
Q
H
M
F
A
A
Q
------
Q
-
G
L
D
L
G
E
R
M
K
H
A
M
Q
K
A
F
D
D
G
Y
D
R
----------------
V
V
L
M
G
S
D
I
P
D
Y
P
C
E
L
V
Q
K
A
L
N
D
L
Q
H
Y
D
A
A
I
-----
G
-
P
A
F
D
G
G
Y
Y
L
I
G
F
R
K
D
---
S
FC
P
D
V
F
D
G
I
R
W
G
E
-----
A
D
V
Y
Q
P
T
V
E
K
M
R
R
A
R
L
E
V
-------------
L
Q
L
P
D
-
W
N
D
V
D
T
V
W
D
L
N
V
L
-
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
60.39
19%
62
- C4 -
-
4R6H
-
MSME_BACSU
A:
[28-421]
ADT
A
K
K
T
L
T
I
Y
---
S
T
M
S
----
T
D
S
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
H
S
D
-----
I
H
V
S
L
H
-
F
P
G
N
D
Y
E
N
-
M
M
R
V
R
M
A
A
N
D
--
L
P
D
L
F
D
-------------------
T
H
G
W
G
K
I
R
Y
G
E
Y
T
A
D
L
R
D
M
-
K
W
----------------
T
Q
D
L
D
P
N
L
N
S
I
L
K
----------
N
K
S
G
K
V
Y
-----
A
Y
P
I
N
Q
A
K
D
G
L
A
Y
N
R
N
I
---
L
--
D
-
R
Y
G
----------------------------
I
-------------
A
P
P
E
T
-
M
D
D
F
I
K
A
L
R
T
I
K
E
-
K
-
S
-------
K
G
S
I
V
P
F
-
W
F
A
G
Y
D
-----
K
S
S
F
A
Q
Y
---
Y
-------------
D
-----
Q
F
A
T
P
L
L
I
T
D
-----
P
A
H
-
N
E
K
K
Q
L
I
--------------------------------------
N
G
-----
T
F
----------------------------------------------
Q
W
S
K
-------------------
F
-----------
T
-
Y
L
S
E
I
L
K
Q
M
---------
Q
-------
K
E
K
L
I
-
N
-
I
D
------
A
--
V
T
-
A
------
K
---
K
S
Q
L
I
E
-------
L
M
A
Q
N
-
K
I
A
F
T
---
M
----
Q
----------------
G
------------
G
--
T
L
G
Q
-
D
V
-------
A
Q
I
N
P
N
V
K
-------------
V
G
-------
I
----
I
P
T
P
A
I
---
H
P
G
D
-----
D
P
I
W
I
-
G
-
G
--
E
----
R
--
Y
---
T
L
A
-
A
W
K
D
S
P
Q
L
K
E
A
K
D
F
I
A
F
-
M
A
R
P
A
N
A
K
Q
-
M
A
----------
E
A
--
T
S
----------
L
P
S
GLT
N
V
K
A
D
-
I
F
Y
A
N
D
Y
--
E
--------------
Y
Y
Q
--
D
V
K
V
E
--------
P
Y
F
D
R
L
Y
L
P
N
G
-------
M
W
D
V
L
G
T
-----
V
G
Q
-----
E
L
A
A
D
I
L
A
----
P
Q
D
I
S
Q
K
L
G
R
E
-----
Y
K
R
L
R
E
Q
S
E
T
-----
54
Fugue
60.15
13%
-9
- C6 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
--------------
S
A
F
T
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
R
V
D
S
G
L
T
-----
P
L
N
S
Y
-----------------------------------------------------------------
E
N
-
R
V
----------------
Y
Q
F
Q
D
E
D
R
R
R
F
V
V
K
F
Y
R
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
W
T
A
D
Q
I
L
E
E
----
H
Q
F
A
L
Q
-
L
V
N
D
E
---
V
--
P
-
V
--
A
A
P
V
A
F
N
--
G
Q
-----
T
L
-
L
N
H
Q
G
F
Y
F
A
V
F
P
S
---
V
G
G
R
-
Q
F
E
-----
A
DN
I
------
D
-----
Q
M
E
A
-------------------
V
-----------
G
-
R
Y
L
G
R
M
H
Q
T
G
R
KQ-----
L
-------
F
I
H
R
P
-
T
-
I
G
------
L
--
N
E
-
Y
------
L
---
I
E
P
R
K
L
-------
F
E
D
A
T
-
L
I
P
S
G
-----------------
L
-------
K
------------
A
--
A
F
L
K
-
A
T
-------
D
E
L
I
A
A
V
T
A
------------
H
W
-------
R
-
E
D
F
--
T
V
L
R
L
H
G
D
C
H
A
-----
G
N
I
L
W
-
R
-
D
--
G
-------
P
---
M
F
V
-
D
L
D
D
-
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
--------
N
G
----------
D
K
--
A
E
----------
Q
R
M
---
Q
L
E
T
I
-
I
E
A
Y
E
E
F
--
S
--------------
E
F
D
--
T
A
E
I
G
--------
L
I
E
P
L
R
A
M
R
L
V
-------
Y
Y
L
A
W
L
M
R
R
WAD
P
A
F
-----
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
-----
A
K
V
L
Q
E
P
P
L
Q
L
T
PMY
36
HHSearch
60.13
19%
-21
- C6 -
-
3C5I
3
?
D:
[11-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
P
L
Y
I
K
K
I
C
L
E
-
K
V
P
EWNHFTE
D
N
L
R
V
K
Q
-
I
L
--
L
T
-----
N
Q
L
F
-
E
V
---
G
L
K
E
E
T
A
N
N
Y
NSIR
T
-----
R
V
L
F
R
I
Y
G
K
H
-----
V
D
E
---
L
Y
N
T
I
S
E
----
F
E
V
Y
K
T
-
M
S
K
Y
K
---
I
--
A
-
P
--
Q
L
L
N
T
F
---------------
N
G
---
G
R
I
E
E
W
---
L
Y
G
D
-
P
L
R
-----
I
--
D
D
L
K
N
P
-
T
-----
I
L
I
G
-------------------
I
-----------
A
-
N
V
L
G
K
F
H
T
L
---------
S
-------
R
K
R
H
L
-
P
-
E
H
------
W
--
D
--
R
------
T
---
P
C
I
F
K
M
-------
M
E
K
W
K
-
N
Q
L
F
K
---
Y
----
K
NIE
K
----
Y
NCD----
I
------------
H
--
K
Y
I
K
-
E
S
-------
D
K
F
I
K
F
M
K
V
------------
Y
S
-------
K
S
D
N
L
A
N
T
I
V
F
C
H
N
D
L
Q
E
-----
N
N
I
I
N
-
T
-
N
--
K
----
C
--
L
---
R
L
I
-
D
F
E
Y
-
S
G
F
N
F
L
A
T
D
I
A
N
-
F
F
I
E
T
S
I
D
Y
-
S
V
SSYPF
F
E
I
D
K
K
K
--
Y
I
----------
S
Y
E
---
N
R
K
L
F
-
I
T
A
Y
L
S
N
--
Y
-----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
58.91
29%
-36
- C7 -
-
3CGX
1
?
A:
[7-198]
-------
I
L
F
F
---
V
K
Y
P
E
P
G
K
V
K
T
R
L
G
E
V
V
G
N
D
K
A
A
M
L
Y
R
H
F
-----
V
Q
D
M
L
Q
G
L
A
R
L
H
A
D
L
H
I
C
Y
V
P
G
D
A
D
L
--
P
-
E
K
F
K
----
A
W
-
L
G
P
Q
H
M
F
A
A
Q
Q
-
G
L
D
L
G
E
R
M
K
H
A
M
Q
K
A
F
D
D
G
Y
D
R
----------------
V
V
L
M
G
S
D
I
P
D
Y
P
C
E
L
V
Q
K
A
L
N
D
L
Q
H
Y
D
A
A
I
-----
G
-
P
A
F
D
G
G
Y
Y
L
I
G
F
R
K
D
SFC
P
--
D
-
V
F
D
G
I
R
W
G
E
-----
A
D
V
Y
Q
P
T
V
E
K
M
R
R
A
R
L
E
V
-------------
L
Q
L
P
D
-
W
N
D
V
D
T
V
W
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
58.86
12%
-58
- C6 -
-
2QG7
-
?
A:
[50-458]
-------
Y
P
I
T
---
E
S
N
L
R
I
L
E
G
E
D
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
F
--------
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
-
M
L
H
Y
G
K
D
--
L
--
V
-
N
P
N
E
----
V
D
-
S
L
E
F
------
Q
-
I
I
N
G
T
N
I
L
I
K
V
K
D
M
S
K
Q
A
K
-
Y
L
----------------
I
R
L
Y
G
P
T
D
E
I
I
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
N
I
A
K
-----
K
-
I
Y
V
F
F
T
N
G
R
I
E
E
F
M
D
---
G
--
Y
-
A
L
S
R
E
D
I
K
N
-----
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
-------------------------------------------------------------------------------------------------------------------------------
D
I
K
L
N
E
-
N
L
Y
K
E
---
L
--
Q
-
V
--
T
Q
K
V
P
G
T
--
R
P
-----
S
F
-
L
W
N
T
---
I
W
K
Y
F
H
---
L
L
N
E
-
E
R
K
-----
K
--
I
------
C
-----
S
---------------------------------------
F
D
A
K
A
N
---------
I
-------
L
K
L
I
D
-
F
-
D
V
------
L
--
R
D
-
S
------
I
---
V
E
V
E
S
L
-------
C
K
R
E
N
-
S
------------------------------------------------------------------------------------------------
P
I
V
L
C
H
C
D
L
L
S
-----
S
N
I
I
N
-
T
-
V
--
G
----
E
--
G
D
S
I
S
F
I
-
D
F
E
Y
-
S
C
P
M
E
R
A
Y
D
I
A
N
-
H
F
N
E
Y
A
G
F
N
C
D
W
----------
D
L
--
T
P
----------
S
K
E
---
E
E
Y
H
F
-
I
M
H
Y
L
G
T
DD
E
--------------
E
L
I
--
N
Q
L
I
R
--------
E
I
Q
P
F
Y
I
C
S
H
I
-------
N
W
G
L
W
S
L
-----
L
Q
G
-----
M
H
S
F
-------
D
F
I
N
Y
G
M
T
R
L
T
A
-----
S
C
L
P
I
F
R
S
K
V
-----
24
HHSearch
55.24
16%
14
- C6 -
-
1ZYL
-
SRKA_ECOLI
A:
[30-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
P
-
L
-
N
S
Y
E
-----
N
R
V
Y
-
Q
F
---
Q
-------------
D
EDR
R
-
R
F
V
V
K
F
Y
R
P
E
-----
R
W
T
---
A
D
Q
I
L
E
E
----
H
Q
F
A
L
Q
-
L
V
N
D
E
---
V
P-
V
-
A
--
A
P
V
A
F
N
G
--
Q
T
L
L
---
N
H
-
Q
G
F
Y
---
F
A
V
F
P
S
---
V
G
G
R
-
Q
F
E
-----
A
--
D
------
N
I
D
---
Q
M
E
A
-------------------
V
-----------
G
-
R
Y
L
G
R
M
H
Q
T
---------
G
-------
R
K
Q
L
F
-
I
-
H
R
------
P
--
T
I
-
G
------
L
---
N
E
Y
L
I
E
-------
P
R
K
L
F
-
E
D
A
T
L
---
I
P---
S
---
G
----
L
-------
K
------------
A
--
A
F
L
K
-
A
T
-------
D
E
L
I
A
A
V
T
A
------------
H
W
----------
R
E
D
F
T
V
L
R
L
H
G
D
C
H
A
-----
G
N
I
L
W
-
R
-
D
-------
G
--
P
---
M
F
V
-
D
L
D
D
-
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
N
G
D
K
A
--------------------
E
----------
Q
R
M
---
Q
L
E
T
I
-
I
E
A
Y
E
E
F
--
S
--------------
E
F
D
--
T
A
E
I
G
--------
L
I
E
P
L
R
A
M
R
L
V
-------
Y
Y
L
A
W
L
M
-----
R
R
W
------------------------------------------------
48
Fugue
53.15
13%
12
- C6 -
-
3HAM
3
?
A:
[1-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
V
N
L
D
A
E
I
Y
E
H
L
N
K
-
Q
-
I
-------
K
I
N
E
L
R
Y
-
L
S
S
G
D
D
-----
S
D
T
F
-
L
C
---
N
-------------
E
-----
Q
Y
V
V
K
V
P
--------
K
R
D
-
S
V
R
I
S
Q
K
R
E
----
F
E
L
Y
R
F
-
L
E
N
C
K
---
L
--
S
Y
Q
--
I
P
A
V
V
Y
Q
--
S
D
R
F
N
I
M
K
Y
-
I
K
G
E
---
R
I
T
Y
E
Q
---
Y
H
K
L
-
S
E
K
-----
E
--
K
------
D
-----
A
L
A
Y
D
------------------
E
-----------
A
-
T
F
L
K
E
L
H
S
I
---------
E
-------
I
D
C
S
V
-
S
-
L
F
------
S
--
D
A
-
L
------
V
N
K
K
D
K
F
L
Q
D
-------
K
K
L
L
I
-
S
I
L
E
K
---
E
----
Q
---
L
----
L
-------
T
------------
D
--
E
M
L
E
-
H
I
-------
E
T
I
Y
E
N
I
L
N
------------
N
A
-------
V
-
L
F
K
-
Y
T
P
C
L
V
H
N
D
F
S
A
-----
N
N
M
I
F
R
N
-
N
--
R
----
L
--
F
---
G
V
I
-
D
F
G
D
-
F
N
V
G
D
P
D
N
D
F
L
---
C
L
L
D
C
S
T
D
-
D
F
----------
G
K
--
E
F
----------
G
R
K
---
V
L
K
----
Y
Y
Q
H
K
A
--
P
--------------
E
V
A
--
E
R
K
A
E
--------
L
N
D
V
Y
W
S
I
D
Q
I
-------
I
Y
G
Y
E
R
K
-----
D
R
E
-----
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
------------------------
46
Fugue
51.76
15%
46
- C6 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------
S
A
E
D
A
-
K
K
L
T
E
L
A
E
N
V
L
Q
G
W
D
-
V
-------
Q
A
E
K
I
D
V
-
I
Q
A
L
V
W
-----
K
V
H
T
-
D
S
---
G
-------------
A
-----
V
C
L
K
R
I
H
R
P
------------
E
K
K
A
L
F
S
----
I
F
A
Q
D
Y
-
L
A
K
K
G
M--
N
--
V
-
P
--
G
I
L
P
N
K
K
--
G
S
-----
L
Y
-
S
K
H
G
S
F
L
F
V
V
Y
D
W
---
I
E
G
R
-
P
F
E
-----
L
--
T
------
V
-----
K
Q
D
L
-------------------
E
F
----------
I
M
K
G
L
A
D
F
H
T
A
S
VG
Y
Q
P
P
NG
V
-------
P
I
F
T
K
-
L
-
G
R
------
W
--
P
N
-
H
------
Y
---
T
K
R
C
K
Q
M
------
E
T
W
K
L
M
A
E
A
E
K
---
E
D
P
F
S
Q
---
L
----
Y
-------
L
------------
Q
--
E
I
D
G
-
F
I
-------
E
D
G
L
R
I
K
D
R
------------
L
L
Q
ST
Y
V
P
W
T
-
E
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
-----
G
N
T
L
L
-
G
E
N
--
E
----
Q
--
I
---
W
V
I
-
D
L
D
T
-
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
L
L
D
T
T
G
-
V
---------------------------
W
D
D
---
E
T
F
N
V
M
L
N
A
Y
E
S
R
--
A
--------------
P
L
T
--
E
E
Q
K
Q
V
M
F
I
D
M
L
F
P
Y
E
L
Y
D
V
I
R
E
K
-------
Y
V
R
K
S
A
L
-----
P
K
E
-----
E
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
-----------------------
50
Fugue
51.64
14%
13
- C6 -
-
3JR1
3
?
A:
[14-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
-
A
-
Y
-------
Y
F
I
K
H
K
E
-
K
L
Y
S
G
E
M----
N
E
I
W
-
L
I
N
DE
V
-------------
Q
-----
T
V
F
V
K
I
N
E
R
S
-----
Y
R
S
M
F
-----
R
A
E
----
A
D
Q
L
A
L
-
L
A
K
T
N
---
S
--
I
-
N
--
V
P
L
V
Y
G
I
--
G
N
-----
S
Q
--
G
H
S
---
F
L
L
L
E
A
---
L
N
K
S
-
K
N
K
--------
Q
------
S
-----
S
F
T
I
-------------------
F
-----------
A
-
E
K
I
A
Q
L
H
Q
I
---------
Q
GPDKYGL
D
F
D
T
W
-
L
-
G
P
------
I
--
Y
Q
-
P
N
D
W
QTS
W
---
A
K
F
F
S
E
NR-----
I
G
W
Q
L
-
Q
I
C
K
E
---
K
----
G
---
L
----
I
-------
F
------------
G
--
N
I
D
L
-
I
V
-------
Q
I
V
A
D
T
L
S
K
------------
H
N
-------------
P
K
P
S
I
L
H
G
N
L
W
I
-----
E
N
C
I
Q
-
V
-
D
--
D
----
K
--
I
---
F
V
C
-
N
P
A
C
--
Y
W
G
D
R
E
C
D
I
A
F
-
S
S
L
F
E
P
F
P
--------------------------------------
T
N
F
-
Y
Q
R
Y
N
E
I
--
Y
--------------
P
L
E
--
E
G
Y
L
E
--------
R
K
L
I
Y
Q
L
Y
Y
L
L
-------
N
F
S
Y
R
Y
Y
-----
N
K
K
-----
Q
-----
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
---------------------
23
HHSearch
50.59
12%
-6
- C6 -
-
4PDY
1
?
A:
[54-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
A
A
K
R
S
S
I
A
-----------
P
A
H
C
R
I
M
----
V
Q
C
L
R
H
-
A
Q
E
Q
G
---
F
TK
F
-
A
--
R
F
V
T
T
S
S
--
N
A
P
Y
V
--
R
H
-
G
D
F
T
---
Y
Y
V
T
E
W
---
V
S
G
Q
-
P
A
N
-----
F
--
G
L
P
----
E
-----
H
V
A
Q
-------------------
T
-----------
A
-
Y
T
L
A
Q
F
H
E
A
---------
T
-------
R
S
F
R
T
D
W
K--DD----
V
--
F
G
-
L
------
F
---
Q
A
R
W
R
D
-------
L
R
Q
M
W
-
L
G
A
D
R
KRE
K
----
D
---
A
----
F
-------
D
------------
Q
--
L
L
L
S
-
M
R
-------
D
E
L
H
R
D
A
A
E
S
L
A
L
F
E
D
R
D
V
I
A
Y
L
-------
E
--
A
E
R
S
S
G
G
W
C
H
L
D
V
I
P
-----
S
N
C
L
Y
-
T
-
P
Q-
H
----
Q
--
V
---
V
L
I
-
D
F
E
L
-
A
R
P
A
P
R
A
L
D
M
A
H
-
L
L
R
R
S
L
E
---
R
G
--------------
N
W
----------
D
G
H
---
L
A
Y
A
C
-
F
L
H
F
D
A
V
--
R
--------------
N
I
P
--
K
S
E
Y
R
--------
A
V
E
A
I
L
R
F
P
Y
L
-------
P
W
R
I
A
H
A
-----
R
Y
H
-----
F
-----
A
A
D
P
S
Q
L
D
A
L
Q
Q
Y
A
V
Q
A
E
K
R
Q
A
F
L
A
S
L
R
Q
Q
V
------
52
Fugue
50.15
10%
-11
- C6 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-------------------------------------------------------------------------------------------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
---------------------------
A
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
T
I
I
-----
L
-
T
A
R
W
Q
Q
D
G
--------------------------------------------------------------------------------
R
-
S
-------
I
Q
Q
K
L
V
A
-
R
V
A
P
A
A
-----
E
D
V
P
-
V
F
---
P
-------------
T
-----
Y
----------------------
R
L
D
H
Q
----
F
E
V
I
R
L
-
V
G
E
L
T
---
D
--
V
-
P
VP
R
V
R
W
I
E
T
--
T
G
-----
D
V
-
L
G
T
P
---
F
F
L
M
D
Y
---
V
E
G
V
-
V
P
P
-----
D
--
V
------
M
-----
P
Y
T
F
GDNWFADAP
A
E
R
Q
R
Q
L
Q
D
A
T
-----------
V
-
A
A
L
A
T
L
H
S
I
---------
P
-------
N
A
Q
N
T
-
F
-
S
F
------
L
--
T
D
-
T
------
T
---
L
H
R
H
F
N
-------
W
V
R
S
W
-
Y
D
F
A
V
---
E
----
G
---
I
----
G
-------
R
------------
S
-----
P
-
L
L
-------
E
R
T
F
E
W
L
Q
S
H
-----------
W
P
-------
D
-
D
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
-----
G
N
V
L
Y
-
R
-
D
--
F
----
Q
--
P
---
V
A
V
L
D
W
E
M
-
V
A
L
G
P
R
E
L
D
V
A
W
-
M
I
F
A
H
R
V
F
Q
-
E
L
----------
A
G
--
L
A
----------
T
L
P
---
G
L
P
E
V
-
M
R
E
D
D
V
R
--
A
--------------
T
Y
Q
--
A
L
T
G
V
--------
E
L
G
D
L
H
W
F
Y
V
Y
-------
S
G
V
M
W
A
C
-----
V
F
M
-----
R
T
G
A
R
R
V
H
F
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
-----
H
A
G
L
M
K
H
L
L
G
E
E
H--
19
PsiBlast_PDB
49.07
21%
-58
- C6 -
-
6CH4
1
AACA_STAAU
A:
[12-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
A
M
K
Y
L
I
E
H
Y
F
D
-
N
-
F
-------
K
V
D
S
I
E
I
-
I
G
S
G
Y
D
-----
S
V
A
Y
-
L
V
---
N
-------------
N
-----
E
Y
I
F
K
T
K
F
S
T
-----
N
K
K
-
K
G
Y
A
K
E
K
A
I
----
Y
N
F
L
N
T
N
L
E
T
N
V
---
K
--
I
-
P
--
N
I
E
Y
------------
S
Y
-
I
S
D
E
---
L
S
I
L
G
Y
K
E
-
I
K
G
T
-
F
L
T
-----
P
--
E
------
I
-----
Y
S
T
M
-------------------
S
E
E
E
Q
N
L
L
K
R
D
I
A
-
S
F
L
R
Q
M
H
G
L
---------
D
-------
Y
T
D
I
S
-
E
-
C
T
------
I
--
D
N
-
K
--------------
Q
N
-------
V
L
E
E
Y
-
I
L
L
R
E
---
T
--------
I
----
Y
-------
N
------------
D
LT
D
I
E
K
D
Y
I
-------
E
S
F
M
E
R
L
N
A
------------
T
T
-------
V
-
F
E
--
G
K
K
C
L
C
H
N
D
F
N
C
-----
N
H
L
L
L
-
D
-
G
--
N
----
N
RL
T
---
G
I
I
-
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
49.05
14%
15
- C6 -
-
2QG7
-
?
D:
[110-430]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
F
Q
I
-
I
N
G
G
-
T
-----
N
I
L
I
-
K
V
---
K
-------------
D
MSKQA
K
Y
L
I
R
L
Y
G
P
K
-----
T
D
------
N
R
E
R
E
----
K
K
I
S
C
I
-
L
Y
N
K
N
---
I
--
A
-
K
--
K
I
Y
V
F
F
T
--
N
----------------
G
R
I
E
E
F
---
M
D
G
Y
-
A
L
S
-----
R
--
E
------
D
IKNPK
F
Q
K
L
-------------------
I
-----------
A
-
K
N
L
K
L
L
H
D
I
---------
K
-------
L
N
E
N
L
-
Y
-
K
E
LQVTQK
V
--
P
G
T
R
------
P
---
S
F
L
W
N
T
-------
I
W
K
Y
F
-
H
L
L
N
E
---
E
----
R
---
K
KICS
F
DAKANIL
K
------------
L
--
I
D
F
D
-
V
L
-------
R
D
S
I
V
E
V
E
S
------------
L
C
-------
K
--
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
-----
S
N
I
I
N
-
T
-
V
G-
D
----
S
--
I
---
S
F
I
-
D
F
E
Y
-
S
C
P
M
E
R
A
Y
D
I
A
N
-
H
F
N
E
Y
A
G
F
--
N
C
----------
D
W
DL
T
P
----------
S
K
E
---
E
E
Y
H
F
-
I
M
H
Y
L
G
T
--
D
--------------
D
E
E
LI
N
Q
L
I
R
--------
E
I
Q
P
F
Y
I
C
S
H
I
-------
N
W
G
L
W
S
L
-----
L
Q
G
------------------------------------------------
28
HHSearch
48.69
14%
-24
- C6 -
-
3DXQ
-
?
B:
[21-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
E
-
R
L
G
G
L
T
-----
N
L
V
F
-
R
A
-----------------
G
-----
D
L
C
L
R
I
P
----------------
N
R
A
N
E
----
A
V
A
A
R
E
-
A
A
K
A
G
---
V
--
S
-
P
--
E
V
L
H
V
D
P
--
A
-----------
T
G
---
V
M
V
T
R
Y
---
I
A
G
A
Q
T
M
S
-----
P
--
E
K
F
K
T
R
P
G
-----
S
P
A
R
-------------------
A
-----------
G
-
E
A
F
R
K
L
H
G
S
---------
G
-------
A
V
F
P
F
-
R
-
F
E
-------------------------
L
F
A
M
-------
I
D
D
Y
L
-
K
V
L
S
T
---
K
----
N
---
V
T
---
L
-------
P
------------
A
--
G
Y
H
--
D
V
-------
V
R
E
A
G
G
V
R
S
------------
A
L
-------
A
--
A
H
P
L
P
L
A
A
C
H
C
D
P
L
C
-----
E
N
F
L
D
-
T
-
G
--
E
----
R
--
M
---
W
I
V
-
D
W
E
Y
-
S
G
M
N
D
P
L
W
D
L
G
D
-
L
S
V
E
G
---------------------
K
F
----------
N
A
N
---
Q
D
E
E
L
-
M
R
A
Y
F
G
G
--
E
--------------
A
R
---
P
A
E
R
G
--------
R
V
V
I
Y
K
A
M
C
D
L
-------
L
W
T
L
W
G
L
-----
I
--------------------------------------------------
62
SP3
48.55
7%
3
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
---
K
--
E
-
L
L
S
T
M
D
L
D
T
DANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
------------------
L
G
G
A
-
W
K
T
V
P
-
L
E
H
L
-----------------
R
I
S
R
-
I
K
G
G
M
S
-----
N
M
L
F
-
L
C
---
R
L
S
EVYPPIRNEP-
N
-----
K
V
L
L
R
V
Y
F
N
P
-----
E
----
T
E
S
H
L
V
A
E
----
S
V
I
F
T
L
-
L
S
E
R
H
---
L
--
G
-
P
--
K
L
Y
G
I
F
S
--
G
----------------
G
R
L
E
E
Y
---
I
P
S
R
-
P
L
S
C
H
E
I
S
L
--
A
------
H
-----
M
S
T
K
-------------------
I
-----------
A
-
K
R
V
A
K
V
H
Q
L
---------
E
-------
V
P
--------------
I
--
W
K
-
E
------
P
---
D
Y
L
C
E
A
-------
L
Q
R
W
L
-
K
Q
L
T
G
---
T
----
V
---
D
----
A
-------
E
H
R
F
D
L
PEECGVS
S
--
V
N
C
L
-
D
L
-------
A
R
E
L
E
F
L
R
A
------------
H
I
-------
S
-
L
S
K
S
-
P
V
T
F
C
H
N
D
L
Q
E
-----
G
N
I
L
L
-
P
-
K
--
R
----
L
------
V
L
I
-
D
F
E
Y
-
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
I
E
W
T
I
D
Y
-
D
I
----------
D
E
--
A
P
F
Y
K
I
Q
TENFP
E
N
D
---
Q
M
L
E
F
-
F
L
N
Y
L
R
E
--
Q
--------------
G
N
T
--
R
E
N
E
L
--------
Y
K
K
S
E
D
L
V
Q
E
T
-------
L
P
F
V
P
V
S
-----
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
-----
Y
F
K
H
K
Q
L
L
K
N
L
A
---
25
HHSearch
48.03
12%
35
- C6 -
-
2Q83
4
COTI_BACSU
A:
[34-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
I
D
V
-
I
Q
---------
A
L
V
W
-
K
V
---
H
-------------
T
D
S
G
--
A
V
C
L
K
R
I
H
R
P
-----
E
------
K
K
A
L
F
S
----
I
F
A
Q
D
Y
-
L
A
K
K
G
---
M
N-
V
-
P
--
G
I
L
P
N
K
K
--
G
S
L
Y
S
--
K
H
-
G
S
F
L
---
F
V
V
Y
D
W
---
I
E
G
R
-
P
F
E
-----
L
--
T
V
K
----
Q
-----
D
L
E
F
-------------------
I
-----------
M
-
K
G
L
A
D
F
H
T
A
---------
S
-------
V
G
Y
Q
P
-
P
-
N
G
------
V
P
I
F
T
-
K
------
L
---
G
R
W
P
N
H
Y
T
K
R
C
K
Q
M
E
T
W
K
-
L
M
A
E
A
E
K-
E
----
D
---
P
----
F
-------
S
------------
Q
--
L
Y
L
Q
-
E
I
D
G
F
I
E
D
G
L
R
I
K
D
R
L
L
Q
ST
Y
V
P
-------
W
T
-------
E
--
Q
L
K
K
S
P
N
L
C
H
Q
D
Y
G
T
-----
G
N
T
L
L
-
G
-
E
N-
E
----
Q
--
I
---
W
V
I
-
D
L
D
T
-
V
S
F
D
L
P
I
R
D
L
R
K
-
M
I
I
P
L
L
D
T
T
--------------
G
--
V
W
----------
D
D
E
---
T
F
N
V
M
-
L
N
A
Y
E
S
R
--
A
--------------
P
L
T
--
E
E
Q
K
Q
--------
V
M
F
I
D
M
L
F
P
Y
E
-------
L
Y
D
V
I
R
E
-----
K
-
Y
------
V
R
K
S
A
L
P
K
E
E
L
E
S
A
F
---------------------------
35
HHSearch
48.02
14%
13
- C6 -
-
2QG7
-
?
E:
[110-430]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
F
Q
I
-
I
N
G
-
I
T
-----
N
I
L
I
-
K
V
---
K
-------------
D
MSKQA
K
Y
L
I
R
L
Y
G
P
K
-----
T
D
E
---
I
I
N
R
E
R
E
----
K
K
I
S
C
I
-
L
Y
N
K
N
---
I
--
A
-
K
--
K
I
Y
V
F
F
T
--
N
----------------
G
R
I
E
E
F
---
M
D
G
Y
-
A
L
S
-----
R
--
E
------
D
IKNPK
F
Q
K
L
-------------------
I
-----------
A
-
K
N
L
K
L
L
H
D
I
---------
K
-------
L
N
E
N
L
-
Y
-
K
E
LQVTQK
V
--
P
G
T
R
------
P
---
S
F
L
W
N
T
-------
I
W
K
Y
F
-
H
L
L
N
E
---
E
----
R
---
K
KICS
F
DAKANIL
K
------------
L
--
I
D
F
D
-
V
L
-------
R
D
S
I
V
E
V
E
S
------------
L
C
-------
K
--
R
E
N
S
P
I
V
L
C
H
C
D
L
L
S
-----
S
N
I
I
N
-
T
-
V
GG
D
----
S
--
I
---
S
F
I
-
D
F
E
Y
-
S
C
P
M
E
R
A
Y
D
I
A
N
-
H
F
N
E
Y
A
G
F
--
N
C
----------
D
W
DL
T
P
----------
S
K
E
---
E
E
Y
H
F
-
I
M
H
Y
L
G
T
--
D
--------------
D
E
E
LI
N
Q
L
I
R
--------
E
I
Q
P
F
Y
I
C
S
H
I
-------
N
W
G
L
W
S
L
-----
L
Q
G
------------------------------------------------