@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : L7F658_9ACTN: (2019-01-31 )
MTDAAPPPPGLRAWARRQVGPITAVRDVSHPRPGSRVWHLELGGRLDVFLKAASGPVAYRRESFAYRHAVPALGQGSAPQLIESSAQHLGLLLTAIPGRPLAELDVPPAVRHEAYRQAGVLLARLHQAGELRGEHRTEAEEALRRTAHGAEKHLAAAGDRVSGAERRLVLRLAGELLVLGPVLLGFLHGDAWERNMLWSGRRTAWVDFERARFGAVVQDLVAMYCGAWSEEPGLRPAFFRGFGRELSAQEEHALTCLSALDAVSCLGWAPGQGDLQVAARGRRALDRLMGAYA
Atome Classification :
(20 SA)
-----------.......-.---.10......-..20--.........30---.....---....40...---.-.--------...50.-----.....----.----..--60--.-.......-.70.-.--......80..--..------------.--------...90.......-.-100....----------.-------..110-.......-120..--...----.----------------.----------------130-.-...-.----.-.-140---...----------.-....-150-...-...-.--..--160-.----.-....-----..170......--.---180.------.-.---....190......-.-200---...-...-...210.......220-..-----.---...-.-----230.--..-----..----------------...-.240--..----.--.--.-.--.---250..-...-...260--.-------...-----...----------270.--......280.......290.----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------MTDAAPP-P---
P
G
L
R
A
W
A
RR-QVG---PI
T
A
V
RDVSH----PRPG
S
---
R
V
W
H
L
E
LGG---
R
-
L
--------
D
V
F
L
-K-----AASGP----
V
----
A
Y
--
R
---
R
-
E
S
F
A
Y
R
H-AVPA-L--GQGS
A
P
Q
L
I
E
--
S
S
------------
A
--------
Q
H
L
G
L
L
L
TAIPG-R-PLAELDV----------P-------
P
A
V
R
H
-
E
A
Y
R
Q
A
G
-
V
L
L
A
R
--
L
H
Q
----
A
----------------
G
----------------ELR-G-EH
R
-
T
----
E
-
A
-
E
-
E
---
A
L
R
----------
R
-TAHG-
A
---
E
K
H
-
L
AA-A--GD--RV--S----
G
-
A
E
R
R
-----
L
V
L
R
LAG
E
L
L
V
--
L
---
G
P
V
L
------
L
-
G
---
F
LHG
D
A
W
ERNMLW-S-G-----R
R
T
-
A
W
V
-
D
F
E
R
A
R
F
G
A
V
V
Q
D
L
V
A
-
M
Y
-----
C
---GAW-S-----E--E--PG-----L
R
----------------
P
A
F
-
F
R
G
F--GR----E--L--S-A--
Q
---
E
E
-
H
A
-
L
T
C
-
L
S
A
L
D
A
--
V
-------
S
C
L-----GWA----------PGQG--
D
L
Q
V
A
A
R
G
R
R
A
L
D
R
L
M
GAYA----------------------------
20
Fugue
68.23
13%
10
- C6 -
-
3JR1
3
?
A:
[14-309]
------------
N
L
Y
F
Q
G
M
W
---
K
S
I
S
Q
V
L
A
E
-
Q
F
G
---
A
Y
Y
F
I
K
H
K
E
K
----
L
Y
S
G
E
M--
N
E
I
W
L
I
N
D
E
---
V
-
Q
--------
T
V
F
V
-
K
-----
I
N
E
R
S
----
Y
----
R
S
M
-
F
---
R
-
A
E
A
D
Q
L
A
-
L
L
A
K
-
T
--
N
S
I
N
V
P
L
V
Y
G
I
G
N
S
------------
Q
--------
G
H
S
F
L
L
L
E
A
L
N
K
-
S
-
K
N
--------------------------
K
Q
-
S
S
F
T
I
F
A
-
E
K
I
A
Q
--
L
H
Q
----
I
----------------
Q
GPDKYGLD
F
D
T
W
L
GP
I
Y
Q
P
-
N
-
D
W
Q
-
T
----
S
-
W
-
A
-
K
---
F
F
S
----------
E
-
N
R
I
G
-
W
---
Q
L
Q
-
I
C
K
-
E
--
K
G
--
L
I
--
F
----
G
-
N
I
D
L
-----
I
V
Q
I
V
A
D
T
L
S
K
--
H
---
N
P
-
K
------
P
-
S
---
I
L
H
G
N
L
W
I
E
N
C
I
Q
-
V
-
D
-----
D
K
I
-
F
V
C
-
N
P
A
-
C
Y
W
G
D
R
E
C
D
I
A
F
-
S
--------------
S
-----
L
--
F
--
E
P
-----
F
P
----------------
T
N
F
-
Y
Q
R
Y
--
N
E
----
I
Y
P
L
--
E
-
E
--
G
---
Y
L
-
E
R
-
K
L
I
-
Y
Q
L
Y
Y
L
--
L
-------
N
F
S
-----
Y
R
Y
----------
Y
N
K
K
--
Q
-
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
------------------------------
49
HHSearch
67.49
20%
-5
- C6 -
-
4GKI
1
?
C:
[34-269]
-----------------------------------------------
V
G
----
Q
S
-
G
A
---
T
I
Y
R
L
Y
G
K
P
---
N
A
P
--------
E
L
F
L
-
K
-----
H
G
K
G
S
V
A
--
N
----
D
V
--
T
---
D
-
E
M
V
R
L
N
W
-
L
T
A
F
-----
M
-
P
L
P
T
I
K
H
--
F
I
R
T
----------
P
--------
D
D
A
W
L
L
T
T
A
I
P
G
-
K
-
T
A
F
Q
V
L
E
----------
E
Y
------
P
D
S
G
E
-
N
I
V
D
A
L
A
-
V
F
L
R
R
--
L
H
S
----
I
----------------
P
----------------
V
C
N
-
C
-
P
F
N
-
S
----
D
-
R
-
V
-
F
---
R
L
A
----------
Q
-
A
Q
S
R
-
M
---
N
N
G
-
L
V
D
-
A
--
S
D
--
F
D
--
D
----
E
-
R
N
G
W
-----
P
V
E
Q
V
W
K
E
M
H
K
--
L
LP-
F
S
P
D
------
S
-
V
---
V
T
H
G
D
F
S
L
D
N
L
I
F
-
D
E
G
-----
K
L
I
-
G
C
I
-
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
-
L
W
-----
N
---
C
L
G
-
E
-----
F
--
S
--
P
S
-----
L
Q
----------------
K
R
L
-
F
Q
K
Y
--
G
I
----
D
--
N
--
P
--------
D
M
-
N
K
-
L
Q
F
-
H
L
M
L
D
--------------------------------------------------------------------------------------
19
Fugue
66.71
16%
-4
- C6 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
-------------
T
D
I
T
E
-
D
---
E
L
R
N
F
L
T
Q
Y
-
D
V
G
---
S
L
T
S
Y
K
G
I
A
E
--------
N
---
S
N
F
L
L
H
T
T
K
D
P
L
I
-
L
--------
T
L
Y
E
-
K
-----
K
N
D
L
P
----
F
----
F
L
--
G
---
L
M
Q
H
L
A
A
K
G
L
S
C
P
L
-
P
--
L
P
R
K
D
G
E
L
L
G
--
E
L
------------
S
--------
G
R
P
A
A
L
I
S
F
L
E
G
M
W
-
L
------------------------
R
K
P
E
A
-
K
H
C
R
E
V
G
-
K
A
L
A
A
M
-
H
L
A
----
S
----------------
E
----------------
G
F
E
-
I
-
K
R
P
-
N
----
A
L
S
-
V
-
D
---
G
W
K
----------
V
-
L
W
D
K
-
S
---
E
E
R
-
A
D
E
-
V
--
E
K
--
G
L
--
R
----
E
-
E
I
R
P
-----
E
I
D
Y
L
A
A
H
W
P
-------
K
D
L
P
------
A
-
G
---
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
-
G
D----
E
L
S
-
G
L
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
-----
N
---
A
W
C
-
F
-----
E
--
K
--
D
G
AYN
V
T
K
G
----------------
K
A
L
-
L
E
G
Y
Q
S
V
R
----
P
--
L
--
S
-
E
--
A
---
E
L
-
E
A
-
L
P
L
-
L
S
R
G
S
A
--
L
-------
R
F
F
L
T
R
L
Y
D
W
L
----------
T
T
P
A
--
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
IANVAEYGLA-----------------
48
HHSearch
65.78
20%
-3
- C6 -
-
4GKH
2
?
A:
[34-269]
-----------------------------------------------
V
G
----
Q
S
-
G
A
---
T
I
Y
R
L
Y
G
K
P
---
N
A
P
--------
E
L
F
L
-
K
-----
H
G
K
G
S
V
A
--
N
----
D
V
--
T
---
D
-
E
M
V
R
L
N
W
-
L
T
A
F
-----
M
-
P
L
P
T
I
K
H
--
F
I
R
T
----------
P
--------
D
D
A
W
L
L
T
T
A
I
P
G
-
K
-
T
A
F
Q
V
L
E
----------
E
Y
------
P
D
S
G
E
-
N
I
V
D
A
L
A
-
V
F
L
R
R
--
L
H
S
----
I
----------------
P
----------------
V
C
N
-
C
-
P
F
N
-
S
----
D
-
R
-
V
-
F
---
R
L
A
----------
Q
-
A
Q
S
R
-
M
---
N
N
G
-
L
V
D
-
A
--
S
D
--
F
D
--
D
----
E
-
R
N
G
W
-----
P
V
E
Q
V
W
K
E
M
H
K
--
L
L
P
-
F
S
P
D
------
S
-
V
---
V
T
H
G
D
F
S
L
D
N
L
I
F
-
D
E
G
-----
K
L
I
-
G
C
I
-
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
-
L
W
-----
N
---
C
L
G
-
E
-----
F
--
S
--
P
S
-----
L
Q
----------------
K
R
L
-
F
Q
K
Y
--
G
I
----
D
--
N
--
P
--------
D
M
-
N
K
-
L
Q
F
-
H
L
M
L
D
--------------------------------------------------------------------------------------
52
SP3
64.31
21%
0
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDL
D
T
D
A
N
T
I
-
P
E
L
K
E
R
A
H
M
L
C
A
R
-
F
L
G
---
G
A
W
K
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
MS
N
M
L
F
L
C
R
L
S
E
---
V
-
Y
PPIRNEPN
K
V
L
L
-
R
-----
V
Y
F
N
P
----
E
T
E
--
S
H
--
L
V
A
E
S
-
V
I
F
T
L
L
S
-
E
--------
R
H
L
G
P
K
L
Y
G
--
I
F
------------
S
--------
G
--
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
---
S
C
----------
H
-------
E
I
S
L
A
-
H
M
S
T
K
I
A
-
K
R
V
A
K
--
V
H
Q
----
L
----------------
E
----------------
V
P
I
-
W
-
K
E
P
-
D
----
Y
-
L
-
C
-
E
---
A
L
Q
----------
R
-
W
L
K
Q
-
L
---
T
G
--
T
V
D
-
A
--
E
H
--
R
F
--
D
----
L
-
P
E
E
C
GVSSV
N
C
L
D
L
A
R
E
L
E
F
--
L
---
R
A
H
I
S
L
SKSP
V
-
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
-
P
-
K
-----
R
L
V
--
L
I
-
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
-
H
F
-----
I
E
W
T
I
D
Y
-
D
-----
I
--
D
EA
P
F
-----
Y
K
I
Q
TENFPE
N
D
Q
M
L
E
F
F
L
N
Y
-
L
R
E
Q
--
G
N
TREN
E
--
L
--
Y
-
K
--
K
---
S
E
-
D
L
-
V
Q
E
-
T
L
P
F
V
P
--
V
-------
S
H
F
-----
F
W
G
V
W
G
L
L
Q
V
ELS
P
V
G
F
--
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA------------------------
47
HHSearch
63.95
10%
-4
- C6 -
-
3JR1
3
?
A:
[17-309]
--------------
F
Q
G
M
-
W
---
K
S
I
S
Q
V
L
A
E
-
Q
F
G
A
Y
Y
F
I
K
H
K
E
K
L
Y
S
----
G
E
-
M
N
---
E
I
W
L
I
N
D
E
V
-----
Q
--------
T
V
F
V
-
K
-----
I
N
E
R
S
Y
R
--
S
----
M
F
--
R
---
A
-
E
A
D
Q
L
A
L
-
L
A
K
T
-
N
--
S
I
-
N
V
P
L
V
Y
G
--
I
G
N
S
----------
Q
--------
G
H
S
F
L
L
L
E
A
L
N
K
-
S
-
K
N
K
--------------------------
Q
-
S
S
F
T
I
F
A
-
E
K
I
A
Q
--
L
H
Q
----
I
----------------
Q
----------------
G
P
D
K
Y
-
G
L
D
F
D
T
W
L
G
P
-
I
Y
Q
P
N
D
W
Q
T
S
W
A
---------
K
-
F
F
S
E
N
R
---
I
G
W
Q
L
Q
I
-
C
--
K
E
--
K
---
G
------
L
I
F
G
-----
N
I
D
L
I
V
Q
I
V
A
D
--
T
L
S
K
H
N
P
K
------
P
-
S
---
I
L
H
G
N
L
W
I
E
N
C
I
Q
-
V
-
D
-----
D
K
I
-
F
V
C
-
N
P
-
A
C
Y
W
G
D
R
E
C
D
I
A
F
-
S
S
-----
L
---
F
---------------
E
P
-----
F
P
----------------
T
N
F
-
Y
Q
R
Y
--
N
E
----
I
--
Y
--
P
-
L
E
E
G
---
Y
L
-
E
R
-
K
L
I
-
Y
Q
L
Y
Y
L
--
L
-------
N
F
S
-----
Y
R
Y
----------
Y
N
-
K
--
K
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
------------------------------
39
HHSearch
63.61
17%
-27
- C6 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-281]
--------------
T
D
I
T
-
E
---
D
E
L
R
N
F
L
T
Q
Y
D
V
G
---
S
L
T
S
Y
K
G
I
A
E
--------
N
---
S
N
F
L
L
H
T
T
K
-----
D
--------
P
L
I
L
-
T
-----
L
Y
E
K
-K---
N
----
D
L
--
P
---
F
-
F
L
G
L
M
Q
H
-
L
A
A
K
----
G
L
-
S
C
P
L
P
L
P
--
R
K
------------
D
GEL
L
G
E
L
S
G
R
P
A
A
L
I
S
F
L
E
G
-
M
-
W
L
R
K
-----------------------
P
E
A
-
K
H
C
R
E
V
G
-
K
A
L
A
A
--
M
H
L
----
A
----------------
S
----------------
E
G
F
-
E
-
I
K
R
-
P
----
N
-
A
L
S
-
V
---
D
G
W
----------
K
V
L
W
D
K
-
S
---
E
E
R
-
A
D
---------
E
V
--
E
----
K
-
G
L
R
E
-----
E
I
R
P
E
I
D
Y
L
A
A
--
H
WP-
K
D
L
P
------
A
-
G
---
V
I
H
A
D
L
F
Q
D
N
V
F
F
-
L
G
D
-----
E
L
S
-
G
L
I
-
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
-
C
L
-----
N
---
A
W
C
-
F
EKDGA
Y
--
N
--
V
T
-----
K
G
----------------
K
A
L
-
L
E
G
Y
--
Q
S
----
V
--
R
P
L
S
-
E
--
A
---
E
L
-
E
A
-
L
P
L
-
L
S
R
G
S
A
--
L
-------
R
F
F
-----
L
T
R
----------
L
-----------------------------------------------------
13
Fugue
63.33
8%
-42
- C6 -
-
3HAM
3
?
A:
[1-299]
-----------
M
V
N
-----------
L
D
A
E
I
Y
E
-
H
L
N
---
K
Q
I
K
I
N
E
L
R
Y
----
L
S
S
G
D
---
D
S
D
T
F
L
C
N
E
---
Q
-
Y
--------
V
V
K
V
-
P
-----
K
R
D
S
V
----
R
----
I
S
--
Q
---
K
-
R
E
F
E
L
Y
R
-
F
L
E
N
-
C
--
K
L
S
Y
Q
I
P
A
V
V
--
Y
Q
------------
S
--------
D
R
F
-
N
I
M
K
Y
I
K
G
-
E
-
R
I
T
Y
E
Q
Y
----------
H
K
LS----
E
K
E
K
D
-
A
L
A
Y
D
E
A
-
T
F
L
K
E
--
L
H
S
IEID
C
----------------
S
----------------
V
S
L
-
F
-
S
D
A
-
L
----
V
-
N
-
K
-
K
---
D
K
F
----------
L
-
Q
D
K
K
-
L
---
L
I
S
-
I
L
E
-
K
--
E
Q
--
L
L
--
T
----
D
-
E
M
L
E
-----
H
I
E
T
I
Y
E
N
I
L
N
--
N
---
A
V
L
F
------
K
-
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
-
R
N
N
-----
R
L
F
-
G
V
I
-
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
-
L
L
-----
D
---
C
S
T
-
D
-----
D
F-
G
--
K
E
-----
F
G
----------------
R
K
V
-
L
K
Y
Y
--
Q
H
----
K
--
A
--
P
-
E
--
V
---
A
E
-
R
K
-
A
E
L
-
N
D
V
Y
W
S
--
I
-------
D
Q
I
-----
I
Y
G
----------
Y
E
R
K
--
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
IF--------------------------
33
HHSearch
63.06
13%
-1
- C6 -
-
5IWU
2
?
A:
[1-299]
--------------
M
S
K
D
-
I
---
K
Q
V
I
E
I
A
K
K
H
N
L
F
L--
K
E
E
T
I
Q
F
N
E
S
----
G
L
-
D
F
---
Q
A
V
F
A
Q
D
N
N
---
G
-
I
--------
D
W
V
L
-
R
-----
L
P
R
R
E
D
V
M
-
P
----
R
T
--
K
---
V
-
E
K
Q
A
L
D
L
-
V
N
K
Y
A
I
--
S
F
-
Q
A
P
N
W
I
I
--
Y
----------------------
T
E
E
L
I
A
Y
K
K
L
D
G
-
V
-
P
A
G
T
I
D
H
NIGNYIWEID
I
-------
N
N
V
P
E
-
L
F
H
K
S
L
G
-
R
V
L
A
E
--
L
H
S
----
I
----------------
P
----------------
S
N
K
-
A
-
A
A
L
-
D
----
L
-
V
-
V
-
H
---
T
P
E
----------
E
-
A
R
M
S
-
M
---
K
Q
R
-
M
D
A
-
V
--
R
A
--
K
F
G
V
G
----
E
-
N
L
W
N
-----
R
W
Q
A
W
L
N
D
D
D
M
------
W
P
K
K
------
T
-
G
---
L
I
H
G
D
V
H
A
G
H
T
M
I
-
D
K
D
-----
A
N
V
T
G
L
I
-
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
-
N
Y
-----
R
---
A
---------
F
--
G
--
E
E
-----
G
L
----------------
E
A
L
-
I
L
A
Y
--
K
E
----
I
--
G
--
G
-
Y
--
Y
WPK
M
K
-
E
H
-
I
I
E
-
L
N
A
A
Y
P
--
V
-------
S
I
A
-----
E
F
A
----------
L
V
S
G
--
I
E
E
Y
E
Q
M
A
K
E
A
L
E
V
----------------------------------
38
HHSearch
62.91
12%
2
- C6 -
-
3TDW
1
?
A:
[4-299]
-----------------
N
-
K
---
L
H
Y
T
T
M
I
M
T
-
Q
F
P
DI-
S
I
Q
S
V
E
S
L
G
E
----
G
F
-
R
N
---
Y
A
I
L
V
---
N
---
G
----------
D
W
V
F
-
R
-----
F
P
K
S
Q
Q
G
A
-
D
----
E
L
--
N
---
K
-
E
I
Q
L
L
P
L
-
L
V
G
C
-
V
--
K
V
-
N
I
P
Q
Y
V
Y
--
I
G
------------
K
R
SD-----
G
N
P
F
V
G
Y
R
K
V
Q
G
-
Q
-
I
L
G
E
D
G
M
A
V
L-------
P
-------
D
D
A
K
D
-
R
L
A
L
Q
L
A
-
E
F
M
N
E
--
L
S
A
----
F
----------------
P
----------------
V
E
T
-
A
-
I
S
A
------
G
-
V
-
P
-
V
T
--
N
L
K
----------
N
-
K
I
L
L
-
L
---
S
E
A
-
V
E
D
Q
V
--
F
P
--
L
L
--
D
----
E
-
S
L
R
D
-----
Y
L
T
L
R
F
Q
S
Y
M
T
HP
V
Y--
T
R
Y
T
------
P
-
R
---
L
I
H
G
D
L
S
P
D
H
F
L
T
-
N
-
L
NSRQ-
T
P
L
T
G
I
I
-
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
-
L
L
-----
E
---
D
C
--
G
------------
E
-----
L
F
----------------
T
R
Q
-
V
M
A
Y
--
R
G
----
E
--
V
--
D
L
D
--
T
---
H
I
-
R
K
-
V
S
L
-
F
V
T
F
D
Q
--
V
-------
S
Y
L
-----
L
E
G
----------
L
R
A
R
--
D
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
A
N
------------------------------
14
Fugue
62.61
13%
24
- C6 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
---------LS
A
E
D
A
K
K
L
-
T
---
E
L
A
E
N
V
L
Q
G
-
W
D
V
---
Q
A
E
K
I
D
V
I
Q
A
------------
L
V
W
K
V
H
T
D
S
---
G
-
A
--------
V
C
L
K
-
R
I
HRP
E
K
K
A
L
F
----
S
----
I
F
--
A
---
Q
-
D
Y
L
A
K
K
G
M
N
V
P
G
-
I
--
L
P
N
K
K
G
S
L
Y
S
--
K
H
------------
G
--------
S
F
L
F
V
V
Y
D
W
I
E
G
-
R
-
P
F
E
L
------------------------
T
V
-
K
Q
D
L
E
F
I
M
K
G
L
A
D
--
F
H
T
----
A
S
VG
Y
Q
P
P
NG
V
P
I
F
T
KL
G
----------------
R
W
P
-
N
-
H
Y
T
-
K
----
R
-
C
-
K
-
Q
M
--
E
T
W
K
L
M
A
E
A
E
KED
P
-
F
S
Q
L
-
Y
---
L
Q
E
-
I
D
G
-
F
--
I
E
--
D
G
--
L
----
R
-
I
K
D
R
-----
L
L
Q
S
T
Y
V
P
W
T
E
--
Q
---
L
K
K
S
------
P
-
N
---
L
C
H
Q
D
Y
G
T
G
N
T
L
L
-
G
-
E
-----
N
E
Q
-
I
W
V
I
D
L
D
T
V
S
F
D
L
P
I
R
D
L
R
K
M
I
I
P
L
L
DT
T
---
G
V
W
-
D
-----
D
--
E
--
T
F
-----
N
V
M
---------------
L
N
A
-
Y
E
S
R
---
A
----
P
--
L
--
T
-
E
--
E
---
Q
K
-
Q
V
M
F
I
D
M
L
F
P
Y
E
L
--
Y
-------
D
V
I
-----
R
E
K
YVRKSA----
L
P
K
E
--
E
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
----------------------------
32
HHSearch
62.54
13%
-4
- C6 -
-
5UXA
-
?
A:
[2-299]
---------------
S
K
D
-
I
---
K
Q
V
I
E
I
A
K
K
H
N
L
F
L--
K
E
E
T
I
Q
F
N
E
S
----
G
L
-
D
F
---
Q
A
V
F
A
Q
D
N
N
---
G
-
I
--------
D
W
V
L
-
R
-----
L
P
R
R
E
D
V
M
-
P
----
R
T
--
K
---
V
-
E
K
Q
A
L
D
L
-
V
N
K
Y
A
I
--
S
F
-
Q
A
P
N
W
I
I
--
Y
----------------------
T
E
E
L
I
A
Y
K
K
L
D
G
-
V
-
P
A
G
T
I
D
H
NIGNYIWEID
I
-------
N
N
V
P
E
-
L
F
H
K
S
L
G
-
R
V
L
A
E
--
L
H
S
----
I
----------------
P
----------------
S
N
K
-
A
-
A
A
L
-
D
----
L
-
V
-
V
-
H
---
T
P
E
----------
E
-
A
R
M
S
-
M
---
K
Q
R
-
M
D
A
-
V
--
R
A
--
K
F
G
V
G
----
E
-
N
L
W
N
-----
R
W
Q
A
W
L
N
D
D
D
M
------
W
P
K
K
------
T
-
G
---
L
I
H
G
D
V
H
A
G
H
T
M
I
-
D
K
D
-----
A
N
V
T
G
L
I
-
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
-
N
Y
-----
R
---
A
---------
F
--
G
--
E
E
-----
G
L
----------------
E
A
L
-
I
L
A
Y
--
K
E
----
I
--
G
--
G
-
Y
--
Y
WPK
M
K
-
E
H
-
I
I
E
-
L
N
A
A
Y
P
--
V
-------
S
I
A
-----
E
F
A
----------
L
V
S
G
--
I
E
E
Y
E
Q
M
A
K
E
A
L
E
V
----------------------------------
42
HHSearch
62.52
17%
-7
- C6 -
-
1ZYL
-
SRKA_ECOLI
A:
[12-283]
-----------------
H
-
P
---
D
T
I
M
D
A
L
F
E
H
G
I
R
---
V
D
S
G
L
T
P
L
-
N
----
S
Y
-
E
N
---
R
V
Y
Q
F
Q
D
E
D
---
R
-
R
--------
R
F
V
V
-
K
-----
F
Y
R
P
E
RWT
A
D
----
Q
I
--
L
---
E
-
E
H
Q
F
A
L
Q
-
L
V
N
D
----
E
V
-
P
V
A
A
P
V
A
--
F
N
GQT
L
L
N
H
-----
Q
--------
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
-
Q
F
E
A
-----------------------
D
N
I
-
D
Q
M
E
A
V
G
-
R
Y
L
G
R
--
M
H
Q
----
T
----------------
G
----------------
R
K
Q
-
L
-
F
I
H
-
R
----
P
---
T
-
I
---
G
L
N
----------
E
-
Y
L
I
E
-
P
---
R
K
L
-
F
E
D
-
A
---
T
--
L
I
--
P
SGL
K
A
-
A
F
L
K
-----
A
T
D
E
L
I
A
A
V
T
A
--
H
WR-
E
D
F
T
------
V
-
L
---
R
L
H
G
D
C
H
A
G
N
I
L
W
-
R
-
D
------
G
P
-
M
F
V
-
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
-
L
L
-----
N
---
G
D
K
-
A
-----
E
--
Q
--
R
M
-----
Q
L
----------------
E
T
I
-
I
E
A
Y
--
E
E
----
F
--
S
EF
D
-
T
--
A
---
E
I
-
G
L
-
I
E
P
-
L
R
A
M
R
L
--
V
-------
Y
Y
L
-----
A
W
L
----------
M
R
----------------------------------------------------
50
SP3
62.19
17%
-19
* C6 *
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
------------------------
G
S
P
A
A
W
V
E
-
R
L
F
---
G
Y
D
-
W
A
Q
Q
T
I
----
G
C
S
D
A
---
A
V
F
R
L
S
A
Q
G
---
R
-
P
--------
V
L
F
V
-
K
-----
T
D
L
S
G
----
A
----
L
N
E
L
Q
---
D
-
E
-
A
A
R
L
S
-
W
L
A
T
-
T
--
G
-
V
P
C
A
A
V
L
D
V
V
T
E
------------
A
--------
G
R
D
W
L
L
L
G
E
V
P
G
-
Q
-
D
L
L
S
S
H
L
----------
A
-------
P
A
E
K
V
-
S
I
M
A
D
A
M
-
R
R
L
H
T
LD
P
A
T
----
C
----------------
P
----------------
F
D
H
-
Q
A
K
H
R
-
I
----
E
-
R
-
A
-
R
---
T
R
M
----------
E
-
A
G
L
V
-
D
---
Q
D
D
-
L
D
------
E
--
E
H
--
Q
----
G
L
A
P
A
E
-----
L
F
A
R
L
K
A
R
M
P
D
--
G
---
E
D
--------
L
-
V
---
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
-
G
-----
R
F
S
-
G
F
I
-
D
C
G
R
L
G
V
A
D
R
Y
Q
D
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A
L
-
A
T
-----
R
---
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I
A
-------
E
--
E
--
L
G
G
E
---
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A
----------------
D
R
F
-
L
V
L
Y
--
G
I
----
A
-------
A
--
P
---
D
S
-
Q
R
-
I
A
F
-
Y
R
L
L
D
E
--
F
-------
F
--------------------------------------------------------------------------
31
HHSearch
61.97
12%
24
- C- -
-
3N4U
-
?
A:
[4-298]
----------------
Y
T
-
F
---
D
Q
V
E
K
A
I
E
Q
-
L
Y
P
DF-
T
I
N
T
I
E
I
S
G
E
----
G
N
-
D
C
---
I
A
Y
E
I
---
N
-----
R
--------
D
F
I
F
-
K
-----
F
P
K
H
S
R
G
S
-
T
----
N
L
--
F
---
N
-
E
V
N
I
L
K
R
-
I
H
N
K
-
L
--
P
L
-
P
I
P
E
V
V
F
--
T
G
------------
M
P
S
ETY---
Q
M
S
F
A
G
F
T
K
I
K
G
-
V
-
P
L
T
P
L
L
L
N
N
L-------
P
-------
K
Q
S
Q
N
-
Q
A
A
K
D
L
A
-
R
F
L
S
E
--
L
H
S
----
I
----------------
N
----------------
I
S
G
-
F
-
K
S
N
-
L
--------
V
-
L
---
D
F
R
----------
E
-
K
I
N
E
-
D
---
N
K
K
-
I
K
K
L
L
--
S
R
--
E
L
--
K
----
G
-
P
Q
M
K
-----
K
V
D
D
F
Y
R
D
I
L
E
N-
E
IY-
F
K
Y
Y
------
P
-
C
---
L
I
H
N
D
F
S
S
D
H
I
L
F
-
D
-
T
EKN--
T
I
C
-
G
I
I
-
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
-
L
M
-----
E
---
D
D
E
-
E
-----
Y
--
G
--
M
E
-----
F
V
----------------
S
K
I
-
L
N
H
Y
--
K
H
----
K
--
D
--
I
-
P
--
T
---
V
L
-
E
K
-
Y
R
M
-
K
E
K
Y
W
S
--
F
-------
E
K
I
-----
I
Y
G
----------
K
E
Y
G
--
Y
M
D
W
Y
E
E
G
L
N
E
I
R
S
I
---------------------------------
37
HHSearch
60.99
12%
22
- C6 -
-
4R78
2
?
A:
[18-297]
--------------
G
S
H
M
-
E
---
K
I
I
K
E
K
I
S
S
-
L
L
S
QEE
E
V
L
S
V
E
Q
L
-
G
----
G
M
-
T
N
---
Q
N
Y
L
A
K
T
T
N
---
K
----------
Q
Y
I
V
-
K
-----
F
F
G
K
G
----
T
EKLI
N
R
--
Q
---
D
-
E
K
Y
N
L
E
L
-
L
K
D
--
L
--
G
L
-
D
V
K
N
Y
L
F
--
D
-------------
I
--------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
I
T
L
D
S
----------------------
T
S
I
K
-
T
K
F
D
K
I
A
-
P
I
L
Q
T
--
I
H
T
----
S
----------------
A
----------------
K
E
L
-
R
-
G
E
F
----------------
A
P
F
----------
E
-
E
I
K
K
-
Y
---
E
S
L
-
I
E
E
-
Q
--
I
P
Y-
A
N
--
Y
----
E
-
S
V
R
N
-----
A
V
F
S
L
E
K
R
L
A
D
------
L
G
V
D
------
R
-
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
-
S
P
Q
-----
G
R
L
-
Y
L
I
-
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
-
L
F
-----
L
---
E
S
--
E
-----
F
--
T
--
S
Q
-----
E
E
----------------
E
T
F
-
L
S
H
Y
--
E
S
----
D
--
Q
--
T
-
P
--
V
---
S
H
-
E
K
-
I
A
I
-
Y
K
I
L
Q
D
--
T
-------
I
W
S
-----
L
W
T
----------
V
Y
K
E
E
Q
G
E
D
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
--------------------------------
40
HHSearch
59.64
15%
-18
- C6 -
-
6EF6
2
?
A:
[29-320]
------------------------
T
I
A
Q
Q
A
L
T
-
H
Y
D
VS-
D
N
A
S
L
R
L
L
-
N
----
L
S
-
E
N
---
A
T
Y
L
V
E
D
G
E
-----
H
--------
Q
S
I
L
-
R
-----
V
H
R
Q
D
YHQ
P
H
----
E
I
--
E
---
S
-
E
L
D
W
L
A
A
-
L
R
T
D
-
S
--
D
V
-
T
V
P
T
V
V
P
--
A
R
DGRR
V
V
T
V
D
P
A
D
V
--------
P
R
H
V
V
H
F
E
M
V
G
G
-
A
-
E
P
D
E
E
---------------------
S
L
T
L
-
D
D
F
Q
T
L
G
-
R
I
T
A
S
--
L
H
E
----
H
----------------
S
----------------
Q
R
W
-
T
-
R
P
A
------
G
-
F
-
G
-
R
---
F
S
W
DWE-------
H
-
C
L
G
D
-
T
PRW
G
R
W
-
Q
D
A
-
E
GV
G
A
--
S
E
--
T
A
L
L
-
T
-
R
A
Q
D
-----
L
L
H
R
K
L
E
E
Y
G
S
------
G
P
D
R
------
Y
-
G
---
L
I
H
A
D
L
R
L
A
N
L
L
V
-
D
S
S
TPQ--
R
T
I
-
T
V
I
-
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
-
A
V
-----
S
---
F
I
E
-
H
-----
D
PR
L
--
G
E
-----
W
Q
----------------
E
S
W
-
V
A
G
Y
--
R
S
----
R
--
R
E
L
P
-
A
--
A
---
D
E
-
A
M
-
L
P
S
-
F
V
F
L
R
R
--
L
-------
L
L
L
-----
A
W
M
----------
G
S
----------------------------------------------------
26
Fugue
59.62
17%
4
- C6 -
-
3CSV
11
?
A:
[4-333]
----------------
S
R
-
E
---
D
E
I
R
D
F
L
A
T
-
H
-----------
G
Y
A
D
----
W
N
R
T
P
---
R
Y
Q
R
L
R
S
P
T
---
G
-
A
--------
K
A
V
L
M
D
-----
W
S
P
E
E
----
G
----
G
D
--
T
---
Q
-
P
F
V
D
L
A
Q
-
Y
L
R
N
-
L
--
D
I
-
S
A
P
E
I
Y
A
--
E
E
------------
H
--------
A
R
G
L
L
L
I
E
D
L
G
D
-
A
-
L
F
T
E
V
I
N
----------
N
-------
D
P
A
Q
E
M
P
L
Y
R
A
A
V
-
D
L
L
I
H
--
L
H
D
----
A
----------------
Q
------------------
T
-
P
-
E
L
A
-
R
----
L
-
D
-
P
-
E
---
T
L
S
----------
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M
T
R
L
A
-
F
---
S
E
Y
-
R
Y
A
-
I
--
L
G
--
D
A
--
A
----
E
-
D
N
R
K
-----
R
F
E
H
R
F
A
Q
I
L
S
--
A
---
Q
L
E
G
------
D
M
V
---
F
V
H
R
D
F
H
A
Q
N
L
L
W
-
L
-
P
EREGL
A
R
V
-
G
V
I
-
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
-
L
L
-----
Q
---
D
A
R
-
R
-----
D
--
V
--
P
A
-----
Q
V
----------------
E
A
Q
M
I
D
H
Y
--
I
Q
----
A
--
T
--
G
-
V
--
D
---
E
S
-
H
F
-
R
S
A
-
Y
A
V
I
A
V
--
Q
R
N
M
R
I
L
G
I
F
A
-----
R
L
S
----------
Q
R
F
G
--
K
R
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
HPALASA
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
29
HHSearch
59.60
17%
1
- C6 -
-
5UXD
2
?
A:
[4-299]
---------------
P
E
D
-
L
---
D
A
L
L
D
L
A
A
R
-
H
G
L
DL-
D
G
G
T
L
R
T
E
E
I
----
G
L
-
D
F
---
R
V
A
F
A
R
A
H
D
---
G
-
G
--------
D
W
V
L
-
R
-----
L
P
R
R
P
DV
L
-
E
----
R
A
--
A
---
V
-
E
G
R
L
L
A
M
-
L
A
P
H
-
L
--
D
V
-
A
V
P
D
W
R
I
--
S
----------------------
T
S
E
L
I
A
Y
P
L
L
P
G
-
S
-
P
G
L
T
V
A
A
----------
D
G
E
V
S
W
HV
D
M
A
S
T
-
V
Y
A
R
S
L
G
-
S
V
V
A
Q
--
L
H
A
----
V
----------------
D
----------------
A
E
A
-
A
-
A
A
T
------
G
-
I
-
E
-
V
R
--
S
P
A
----------
Q
-
V
R
G
A
-
W
---
R
Q
D
-
L
A
R
-
V
--
G
A
E
F
E
I
--
A
----
P
-
A
L
R
E
-----
R
W
E
A
W
L
A
D
D
G
C
------
W
P
G
H
------
S
-
V
---
L
T
H
G
E
L
Y
P
A
H
T
L
V
-
E
D
E
-----
R
I
T
-
A
V
L
-
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
-
H
Q
-----
V
---
S
---------
A
--
P
--
S
A
-----
I
F
----------------
E
V
A
-
L
Q
A
Y
--
A
E
----
G
--
G
--
G
-
R
--
P
---
W
P
G
L
A
-
R
H
C
-
T
E
M
F
S
A
A
P
L
-------
G
Y
G
-----
L
Y
A
----------
L
A
T
G
--
E
A
A
H
R
E
A
A
A
A
A
L
N
P
P
E
E
-------------------------------
43
HHSearch
59.52
10%
5
- C6 -
-
5IQC
2
AACA_STAAU
A:
[12-303]
-------------------
V
---
K
A
M
K
Y
L
I
E
H
-
Y
F
D
NF-
K
V
D
S
I
E
I
I
G
S
----
G
Y
-
D
S
---
V
A
Y
L
V
N
--------
N
--------
E
Y
I
F
-
K
-----
T
K
F
S
T
NKK-
K
----
G
Y
--
A
---
K
-
E
K
A
I
Y
N
F
-
L
N
T
N
-
L
ET
N
V
-
K
I
P
N
I
E
Y
--
S
Y
I
S
----------
D
--------
E
L
S
I
L
G
Y
K
E
I
K
G
-
T
-
F
L
T
P
E
I
Y
S
T
M-------
S
-------
E
E
E
Q
N
-
L
L
K
R
D
I
A
-
S
F
L
R
Q
--
M
H
G
----
L
----------------
D
----------------
Y
T
D
-
I
-
S
E
C
------
T
-
I
-
D
-----
N
K
Q
----------
N
-
V
L
E
E
-
Y
---
I
L
L
-
R
E
T
-
I
--
Y
N
--
D
L
--
T
----
D
-
I
E
K
D
-----
Y
I
E
S
F
M
E
R
L
N
A
T-
T
V--
F
E
G
K
------
K
-
C
---
L
C
H
N
D
F
S
C
N
H
L
L
L
-
D
G
N
-----
N
R
L
T
G
I
I
-
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
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Y
-
L
L
-----
E
---
D
S
E
E
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-----
I
--
G
--
T
N
-----
F
G
----------------
E
D
I
-
L
R
M
Y
--
G
N
----
I
--
D
--
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---
A
K
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D
I
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V
E
E
Y
Y
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--
I
-------
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T
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-----
V
Y
G
----------
I
K
N
I
--
K
Q
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F
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N
G
R
K
E
I
Y
K
R
T
Y
-------------------------------