@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_30_2930: (2018-07-13 )
MASNAAANGSFGSSANAVQLVSTQRGRKVYCVRGQSFDIDDNYTVTSVIGHGAYGVVCAALDDRTFQEVAIKRVSRVFEDLIDGRRIWREILLLRILKECGCRNVLRLIRVLPPRDPIMEFRDLYLVTDLYDIDLFSIIRQNKCESIDLLRRISVRVLRCLADMHSMGIVHRDIKPSNILLRDEKNAEEAIVCDFGLARAGLHRLSEPLDLTDYVVTRWYRPPELLLMCPYSYPIDIWAVGCVMAEYAMQRPLFAGRDYIHQLQFVLSSIPITGVDFIERSSSSSGLANMNEIAKKYKGTRPLPQLLSKLPKDGLELVTEMLAFEPNKRITAQEALKHPFFSSVGGPDCKSYPAPPELDLGFDMHAEVSECQLRRAIWDELQYYRK
Atome Classification :
(28 SA)
.........10........20........-30........40.......-.50........60........70........80........90........100.......110..-...-..120........130.......140.....--..150.......160.......170.......180.......190.......200.....-..210--.........220.....-.-.230........240.......250.......260.......270....------.------------...280....---------...290.--...-.--..300-...--.--.--...310-..---......320.......330.......340....----...350.......360....-...370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MASNAAANGSFGSSA
N
A
V
Q
L
V
STQRG
R
K
V
-
Y
C
VRGQSFDIDDN
Y
T
V
T
S
V
-IGHGA
Y
G
V
V
C
A
ALDDR
T
F
Q
E
V
A
I
K
R
V
S
R
V
F
E
D
L
I
D
G
R
R
I
W
R
E
I
L
L
L
R
I
L
K
ECG
C
R
N
V
L
R
L
I
R
VLPP-R
D
P
-
I
M
E
-
F
R
D
L
Y
L
V
T
D
LY
D
I
D
L
F
S
I
I
R
QNKC
E
S
I
--
D
L
L
R
R
I
S
V
R
V
L
R
C
L
A
D
M
H
SMG
I
V
HRDIKPS
N
I
L
L
RDEKNAE
E
A
I
V
C
D
F
G
L
A
R
A
G
L
H
R
LSE-PL
D
----
L
T
D
Y
V
V
T
RWYR
P
P
E
L
L
L
-M-CP-YSY
P
I
D
I
W
A
V
G
C
V
M
A
E
Y
A
M
QRPLFA
G
R
D
Y
I
H
Q
L
Q
F
V
L
S
SI-PIT
G
V
------
D
------------
F
I
ERSSSSSG---------L
A
N
M
N
E
I
--
A
K
K
-Y--KGTR--
P
L
P
--
Q
--
L
--
L
S
KLP--KD---
G
L
E
L
V
T
E
M
LAFEPNKRI
T
A
Q
E
A
LKHPFFSSVGG----PDCKSYPAPPELDLGFDMHA-
E
V
S
E
C
Q
L
R
R
A
I
W
D
E
L
Q
Y
YRK
21
HHSearch
96.68
35%
-62
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[3-343]
--------------------------------------
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
---
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
---
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
----
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
-
S
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
A
V
G
A
E
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-----
Q
P
V
--
P
W
E
--
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
--
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
4
PsiBlast_PDB
93.86
36%
-82
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[2-340]
------------------------------------
T
F
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
---
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
C
E
L
K
I
-
G
D
F
G
M
A
R
-
G
L
--
C
T
S
-
P
A
E
HQYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
A
V
G
A
E
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-------
Q
--
P
V
P
W
E
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
A
-
L
T
R
E
-
R
I
K
E
A
I
V
A
E
I
E
----
7
PsiBlast_PDB
93.85
36%
-72
- C1 -
-
5BYY
1
MK07_HUMAN
A:
[1-338]
-------------------------------------
F
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
---
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
C
E
L
K
I
-
G
D
F
G
M
A
R
-
G
L
---------YF--
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
A
V
G
A
E
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-------
Q
--
P
V
P
W
E
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
A
-
L
T
R
E
-
R
I
K
E
A
I
V
A
E
I
E
----
1
PsiBlast_PDB
93.78
34%
-33
- C1 -
-
4O2Z
1
?
A:
[32-376]
---------------------------
K
V
-
Y
N
V
S
G
S
P
F
E
V
P
S
K
Y
T
L
L
K
I
-
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
D
T
G
E
K
V
S
I
K
K
C
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
---
E
N
L
L
N
V
V
N
I
L
P
P
L
K
R
E
-
Y
H
S
-
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
--
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
---
T
N
I
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
Y
S
E
--------
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
-
T
N
-
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
M
D
Q
L
R
M
I
A
Q
H
I
-
G
K
P
P
A
------
S
------------
I
V
E
H
R
E
A
------------
L
E
K
L
N
E
L
--
P
------
D
G
S
L
--
N
I
P
--
K
--
L
--
V
P
G
L
A
GN
T
E
---
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
------
D
E
E
D
E
P
T
C
P
C
P
F
L
W
A
H
E
S
T
-
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
N
-
5
PsiBlast_PDB
93.60
35%
-84
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[50-388]
------------------------------------
T
F
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
---
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
---
E
L
K
I
G
D
F
G
M
A
R
-
G
L
--
C
T
S
-
P
A
E
HQYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
A
V
G
A
E
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-------
Q
--
P
V
P
W
E
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
A
-
L
T
R
E
-
R
I
K
E
A
I
V
A
E
I
E
----
3
PsiBlast_PDB
93.52
36%
-76
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[1-339]
------------------------------------
T
F
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
---
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
C
E
L
K
I
-
G
D
F
G
M
A
R
-
G
L
--
C
T
S
-
P
A
E
HQYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
A
V
G
A
E
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-------
Q
--
P
V
P
W
E
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
A
-
L
T
R
E
-
R
I
K
E
A
I
V
A
E
I
E
----
9
PsiBlast_PDB
92.03
36%
-80
- C1 -
-
4ZSJ
5
MK07_HUMAN
A:
[1-337]
--------------------------------------
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
---
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
C
E
L
K
I
-
G
D
F
G
M
A
R
-
G
L
--
C
T
S
-
P
A
E
HQYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
A
V
G
A
E
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-------
Q
--
P
V
P
WE
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
A
-
L
T
R
E
-
R
I
K
E
A
I
V
A
E
I
E
----
2
PsiBlast_PDB
91.01
36%
-90
- C1 -
-
4B99
1
MK07_HUMAN
A:
[49-387]
------------------------------------
T
F
D
V
G
D
E
Y
E
I
I
E
T
-
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
---
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
-
T
V
P
-
Y
G
E
-
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
--
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
C
E
L
K
I
-
G
D
F
G
M
A
R
-
G
L
---------QYF-
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
-
G
T
P
S
P
------
A
------------
V
I
Q
-----
R
V
---------
R
A
Y
I
Q
S
L
--
P
P
R
-------
Q
--
P
V
P
W
E
T
--
V
--
Y
P
G
A
D
--
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
----
P
D
D
E
P
D
C
A
P
P
-
F
D
F
A
F
D
R
E
A
-
L
T
R
E
-
R
I
K
E
A
I
V
A
E
I
E
----
24
HHSearch
90.46
36%
-82
- C1 -
-
3N9X
4
?
B:
[23-407]
--------------------------------------
H
V
P
D
N
Y
I
I
K
H
L
-
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
---
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
-
D
D
L
--
L
K
-
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
P
I
F
L
T
E
--
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
C
S
---
V
K
V
C
D
F
G
L
A
R
T
I
N
---------------
S
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
-
E
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
M
L
Q
S
H
I
N
D
P
T
N
R
F
P
L
F
P
G
S
S
C
F-----H
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
IGTP
T
E
D
D
L
K
N
I
-
K
---------
P
E
V
I
K
Y
I
---
K
L
-
F
--
P
H
R
K
P
I
N
L
K
--
Q
--
K
--
Y
P
S
I
S
--
D
D
---
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
----
K
K
L
E
---
T
K
K
-
I
I
L
P
F
D
D
W
M
-
V
L
S
E
T
Q
L
R
Y
I
F
L
K
E
V
Q
S
F
--
23
HHSearch
89.55
35%
-96
- C1 -
-
5CI6
-
MPK6_ARATH
B:
[38-365]
-------------------------------------------
K
P
P
I
M
P
-
I
G
K
G
A
Y
G
I
V
C
S
A
M
N
S
E
T
N
E
S
V
A
I
K
K
I
A
N
A
F
D
N
K
I
D
A
K
R
T
L
R
E
I
K
L
L
---
R
H
M
D
H
E
N
I
V
A
I
R
D
I
I
P
P
-
P
L
R
--
N
A
-
F
N
D
V
Y
I
A
Y
E
L
M
D
T
D
L
H
Q
I
I
R
S
N
Q
A
L
S
E
--
E
H
C
Q
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
A
N
C
D
---
L
K
I
C
D
F
G
L
A
R
V
T
-------------------
V
T
R
W
Y
R
A
P
E
L
L
L
-
N
S
S
D
-
Y
T
A
A
I
D
V
W
S
V
G
C
I
F
M
E
L
M
D
R
K
P
L
F
P
G
R
D
H
V
H
Q
L
R
L
L
M
E
L
I
-
G
T
P
S
---------------------
L
E
F
L
--------------
N
E
N
A
K
R
Y
--
I
R
Q
-
L
P
P
Y
P
R
Q
--
S
I
T
--
D
--
K
--
F
P
T
V
H
--
P
L
---
A
I
D
L
I
E
K
M
L
T
F
D
P
R
R
R
I
T
V
L
D
A
L
A
H
P
Y
L
N
S
L
H
D
----
I
S
D
E
P
E
C
T
I
P
-
F
N
F
D
F
E
N
H
--
A
L
S
E
E
Q
M
K
E
L
I
Y
R
E
A
L
A
F
N
-
29
HHSearch
89.50
33%
-42
- C1 -
-
4O2Z
1
?
A:
[25-375]
--------------------
P
K
I
V
G
D
F
K
V
-
Y
N
V
S
G
S
P
F
E
V
P
S
K
Y
T
L
L
K
I
-
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
D
T
G
E
K
V
S
I
K
K
C
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
---
F
F
H
H
E
N
L
L
N
V
V
N
I
L
P
P
-
L
K
R
E
Y
H
S
-
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
--
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
I
S
C
E
---
L
K
I
I
D
F
G
L
S
R
S
--
V
P
Y
----
S
E
----
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
-
E
N
T
N
-
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
M
D
Q
L
R
M
I
A
Q
H
I
-
G
K
P
P
A
------
S
------------
I
V
E
H
R
E
A
L
------------
E
K
L
N
E
L
--
P
D
------
G
S
L
--
N
I
P
--
K
--
L
V
P
G
L
A
G
N
--
T
E
---
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
----
E
E
D
E
P
T
C
P
C
P
-
F
L
W
A
-
H
E
S
T
-
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
--
26
HHSearch
89.49
34%
-80
- C1 -
-
3COI
-
MK13_HUMAN
A:
[19-350]
-------------------------------------
W
E
L
P
K
T
Y
V
S
P
T
H
-
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
S
G
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
---
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
S
S
-
L
R
N
-
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
G
L
--
K
F
S
E
--
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
L
A
R
H
-------------------
V
V
T
R
W
Y
R
A
P
E
V
I
L
-
S
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
Q
I
L
K
V
T
-
G
V
P
G
T
------
E
------------
F
V
Q
K
L
N
D
K
A
A
---------
K
S
Y
I
Q
S
L
--
P
Q
-----
T
P
R
K
--
D
F
T
--
Q
--
L
--
F
P
R
A
S
--
P
Q
---
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
----
P
E
E
E
T
E
A
Q
Q
P
-
F
D
D
S
L
E
H
-
E
-
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
S
-
33
HHSearch
88.92
33%
-81
- C1 -
-
4XNE
1
MK01_RAT
A:
[6-345]
----------------------------------
G
Q
V
F
D
V
G
P
R
Y
T
N
L
S
Y
-
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
E
H
Q
-
T
Y
C
Q
R
T
L
R
E
I
K
I
L
---
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
-
P
T
I
--
E
Q
-
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
Q
-
H
L
S
N
--
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
---
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
-
T
G
F
----
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
-
G
S
P
S
Q
------
E
------------
D
L
N
C
I
I
N
L
------------
K
A
R
N
Y
L
--
L
S
L
P
H
--
K
N
K
V
--
P
W
N
--
R
--
L
--
F
P
N
A
D
--
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
----
P
S
D
E
P
I
A
E
---
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
-
28
HHSearch
88.44
34%
-82
- C1 -
-
4YNO
-
MK13_HUMAN
A:
[17-349]
-----------------------------------
T
A
W
E
L
P
K
T
Y
V
S
P
T
H
-
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
S
G
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
---
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
S
S
-
L
R
N
-
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
G
M
--
E
F
S
E
--
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
L
A
-------------------
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
-
S
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
Q
I
L
K
V
T
-
G
V
P
G
T
------
E
------------
F
V
Q
K
L
N
D
K
A
A
---------
K
S
Y
I
Q
S
L
--
P
Q
-----
T
P
R
K
--
D
F
T
--
Q
--
L
--
F
P
R
A
S
--
P
Q
---
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
----
P
E
E
E
T
E
A
Q
Q
P
-
F
D
D
S
L
-
E
H
E
-
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
--
39
HHSearch
87.53
35%
-96
- C1 -
-
2YIX
1
MK14_HUMAN
A:
[15-341]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
---
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
--
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
---
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-----------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
---------
R
N
Y
I
Q
S
L
--
T
Q
M
-----
P
K
M
--
N
F
A
--
N
--
V
--
F
I
G
A
N
--
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
-
D
P
-
Y
D
Q
S
F
E
S
R
--
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
------
25
HHSearch
86.43
33%
-83
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[5-345]
---------------------------------
R
G
Q
V
F
D
V
G
P
R
Y
T
N
L
S
Y
-
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
E
H
Q
-
T
Y
C
Q
R
T
L
R
E
I
K
I
L
---
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
-
P
T
I
--
E
Q
-
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
Q
-
H
L
S
N
--
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
---
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
-
T
G
F
----
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
-
G
S
P
S
Q
------
E
------------
D
L
N
C
I
I
N
L
K
A
---------
R
N
Y
L
L
S
L
--
P
---
H
--
K
N
K
V
--
P
W
N
--
R
--
L
--
F
P
N
A
D
--
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
----
P
S
D
E
P
I
A
E
---
A
P
F
-----
D
-
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
-
8
PsiBlast_PDB
85.20
36%
-8
- C1 -
-
5CI6
-
MPK6_ARATH
A:
[16-360]
----------------------
S
H
G
G
R
F
I
Q
Y
N
I
F
G
N
I
F
E
V
T
A
K
Y
K
P
P
I
M
P
I
------
I
V
C
S
A
M
N
S
E
T
N
E
S
V
A
I
K
K
I
A
N
A
F
D
N
K
I
D
A
K
R
T
L
R
E
I
K
L
L
R
H
M
D
H
---
E
N
I
V
A
I
R
D
I
I
P
P
---
P
-
L
R
N
A
F
N
D
V
Y
I
A
Y
E
L
M
D
T
D
L
H
Q
I
I
R
S
N
Q
A
L
S
E
--
E
H
C
Q
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
A
N
C
D
L
K
---
I
C
D
F
G
L
A
R
V
T
---------------------
R
W
Y
R
A
P
E
L
L
L
-
N
-
S
S
D
Y
T
A
A
I
D
V
W
S
V
G
C
I
F
M
E
L
M
D
R
K
P
L
F
P
G
R
D
H
V
H
Q
L
R
L
L
M
E
L
I
----------------------------
G
T
P
S
E
E
E
---------
L
E
F
L
N
E
N
--
A
K
R
-
Y
I
-
R
Q
L
P
--
P
Y
P
--
R
QS
I
--
T
D
K
F
P
--
T
V
H
P
L
A
I
D
L
I
E
K
M
L
T
F
D
P
R
R
R
I
T
V
L
D
A
L
A
H
P
Y
L
N
S
L
H
D
ISDE
P
E
C
-
T
I
P
----
F
N
-----------
E
E
Q
M
K
E
L
I
Y
R
E
------
11
PsiBlast_PDB
83.53
37%
-95
- C1 -
-
6ANL
1
MK14_HUMAN
A:
[23-327]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
K
L
T
D
---
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
---
E
L
K
I
L
D
F
G
L
A
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
-
F
--
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
13
PsiBlast_PDB
82.98
37%
-94
- C1 -
-
3IPH
7
MK14_HUMAN
A:
[18-322]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
---
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
L
-----
H
T
D
D
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
QSLTQ
M
P
K
M
N
-
F
--
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
10
PsiBlast_PDB
82.88
37%
-100
- C1 -
-
5WJJ
1
MK14_HUMAN
A:
[23-327]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
Q
K
L
T
D
---
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
---
E
L
K
I
L
D
F
G
L
A
R
---
H
T
D
D
--------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
--
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
IQQ---
M
P
K
M
N
-
F
--
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
12
PsiBlast_PDB
82.37
37%
-91
- C1 -
-
3D83
2
MK14_HUMAN
A:
[18-322]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
---
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
L
A
R
---
H
T
D
D
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
QSLTQ
M
P
K
M
N
-
F
--
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
34
HHSearch
81.23
35%
-97
- C1 -
-
2FST
3
MK14_HUMAN
X:
[25-351]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
---
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------
Q
K
L
T
D
--
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
---
L
K
I
L
D
--------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
---------
R
N
Y
I
Q
S
L
--
T
Q
M
-----
P
K
M
--
N
F
A
--
N
--
V
--
F
I
G
A
N
--
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--
Y
D
Q
S
L
E
S
R
--
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
------
16
PsiBlast_PDB
77.49
37%
-65
- C1 -
-
3P79
2
MK14_MOUSE
A:
[24-328]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
---
L
A
Q
M
P
K
M
NF
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
15
PsiBlast_PDB
77.41
37%
-65
- C1 -
-
3P78
2
MK14_MOUSE
A:
[24-328]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
---
L
A
Q
M
P
K
M
N
F
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
17
PsiBlast_PDB
76.17
37%
-59
- C1 -
-
3P7A
2
MK14_MOUSE
A:
[24-328]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
---
L
A
Q
M
P
K
M
N
F
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
20
PsiBlast_PDB
76.03
37%
-63
* C1 *
-
3P5K
2
MK14_MOUSE
A:
[24-328]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
---
L
A
Q
M
P
K
M
N
F
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
18
PsiBlast_PDB
75.96
37%
-60
- C1 -
-
3P7B
2
MK14_MOUSE
A:
[24-328]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
QS---
L
A
Q
M
P
K
M
N
F
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------
19
PsiBlast_PDB
75.13
37%
-62
- C1 -
-
3P7C
2
MK14_MOUSE
A:
[24-328]
-------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
-
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
---
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
-
L
E
E
-
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
---
E
L
K
I
L
D
F
G
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
-
G
T
P
G
A
------
E
------------
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
---
L
A
Q
M
P
K
M
NF
A
N
V
-
F
--
I
G
A
N
--
P
L
---------------------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
----
P
D
D
E
P
V
A
D
P
--------------------------------