@TOME V2.3
(Mar 2018)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : LINJ_34_0990: (2018-07-13 )
MRAKIDDENSSVAVTLLPSAQVEPLASSQPPTRTGAVGTMVNTDAIDARGNDAESSGGGSAPSSMATTTTINAVFYNPSAQLPTPPPLHRNSSSPAPMQHLQHEEPQRLRAVPYFPASCESDSNEEPLFQHPPPAKPRAPLRPAPQSGRLWGAVSATPSSAGFVSGGTAPYASLLHTSSAPAVADTETSSTTAGHGLVVGCETSNHCLPASIKAHPPASATSPASIHGGYSDSVSDSTATTTVGNHSSGGRGLRRPPLMTGPNGAAVPLASPMLSGPQGRWVRSSGDESSSGFATLAVPAAPANLGDTVLVAEPPTPTKQRRTIHTGMGNTVSLSCGGIGAAPRLSTSAAASTGTCASAAAATSAAAVAGGASPKPSLRIAAPFRGLGYNPAANSVSAPASRATTSSMSTAPPPPSFKCYRREGSRKRSADVLSQFSALDLDETPATPFAQTGTSRFTSINHNGNGHNAFPSQPSPSTAVYRGAGGGSNAISTVSPLTIDYATPVALSQQIGGSNTFSQVLLHPSQDVLDMSQAETECSNFLARRILKEYNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRRERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPGGSVASVANAKQSRNEPWPEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCSVLLDERGRPRPETRNGYGSLARGQRAGWVGGVACANPNGGPAVHTGAGVGAGGLGSSLDFNNWNEGNELSTMSIDEGDCRYLCADMLNEKQHFKAGDMFSLGMSLFELMSGQPLPRNGDQFLALRRRVPVEVLRRRGYSADLVELVVALLRSDPPQRPTARQVLQYLRLSSEELQLLSSASAMKRWTESAESFLQLQEEERQQPPLGKDGVLAATVDALRCVSALMEASMWLFTTTQQDVHRLAAPANAGKGEDEEDERRRQQTQQPQPQPLLQLPRGQQLEDLPMSPIQCDEACTPTALNY

Atome Classification :

(32 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430...---....440.......450.......460.......470.......480.......490.......500.......510.--......520.......530.......-540..--...-------.----------.550.......560.......570.......580--.....-------...590-----.......600.......610.......620.......630.......640.......650.......660.......670-.......680....---..--.---690--.........700.......710.......720.......730.......740.......750.......760.......770.......780......------.790........800.......810......----------.--820-.---...----.----..-----.830.....-----...----.840.......850.....-----..860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) MRAKIDDENSSVAVTLLPSAQVEPLASSQPPTRTGAVGTMVNTDAIDARGNDAESSGGGSAPSSMATTTTINAVFYNPSAQLPTPPPLHRNSSSPAPMQHLQHEEPQRLRAVPYFPASCESDSNEEPLFQHPPPAKPRAPLRPAPQSGRLWGAVSATPSSAGFVSGGTAPYASLLHTSSAPAVADTETSSTTAGHGLVVGCETSNHCLPASIKAHPPASATSPASIHGGYSDSVSDSTATTTVGNHSSGGRGLRRPPLMTGPNGAAVPLASPMLSGPQGRWVRSSGDESSSGFATLAVPAAPANLGDTVLVAEPPTPTKQRRTIHTGMGNTVSLSCGGIGAAPRLSTSAAASTGTCASAAAATSAAAVAGGASPKPSLRIAAPFRGLGYNPAANSVSAPASRATTSSMSTAPPPPSFKCYRREGSRKRSADVLSQ---FSALDLDETPATPFAQTGTSRFTSINHNGNGHNAFPSQPSPSTAVYRGAGGGSNAISTVSPLTIDYATPVALSQQIGG--SNTFSQVLLHPSQDVLDMSQAETECS-NFLAR--RIL-------K----------EYNEVRLLGSGSFGTVSLFKEISSGEYVAVKM-S--PPLRT-------PEMERR-----YRRERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPGGSVASVANAKQSRNEPWPEAEVKVFLAHMSIALDALHRA-NIAHVDFKPDNVLV---DK--D---G----AYKLSDFGCSVLLDERGRPRPETRNGYGSLARGQRAGWVGGVACANPNGGPAVHTGAGVGAGGLGSSLDFNNWNEGNELSTMSIDEGDCRYLCADMLN------EKQ-HFKAGDMFSLGMSLFELMSGQPLPRNG----------D--QF--L---ALR----R----RV-----PV--EVLRR-----RGY----SADLVELVVALLRSDPPQR-----PTARQVLQYLRLSSEELQLLSSASAMKRWTESAESFLQLQEEERQQPPLGKDGVLAATVDALRCVSALMEASMWLFTTTQQDVHRLAAPANAGKGEDEEDERRRQQTQQPQPQPLLQLPRGQQLEDLPMSPIQCDEACTPTALNY
28 HHSearch 77.8433% -38 - C1 - - 5VCY PMYT1_HUMAN A:[56-309] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-------Q----------SFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-S--MSPFRG------PKDRAR-----KLAEVGSHEKVGQHPCCVRLEQAWEEGG--ILYLQTELC-GPSLQQHCEAWG---ASLPEAQVWGYLRDTLLALAHLHSQ-GLVHLDVKPANIFL---GP--R---G----RCKLGDFGLLVELGTAGA---------------------------------------------------------------GEVQEGDPRYMAPELLQ------G-S-YGTAADVFSLGLTILEVACNMELPHGG----------E--GW--Q---QLR----Q----GY-----LP---PEFT-----AGL----SSELRSVLVMMLEPDPKLR-----ATAEALLALPVLR------------------------------------------------------------------------------------------------------------------------------------
27 HHSearch 77.7633% -38 - C1 - - 5VCZ PMYT1_HUMAN A:[56-309] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-------Q----------SFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-S--MSPFRG------PKDRAR-----KLAEVGSHEKVGQHPCCVRLEQAWEEGG--ILYLQTELC-GPSLQQHCEAWG---ASLPEAQVWGYLRDTLLALAHLHSQ-GLVHLDVKPANIFL---GP--R---G----RCKLGDFGLLVELGTAGA---------------------------------------------------------------GEVQEGDPRYMAPELLQ------G-S-YGTAADVFSLGLTILEVACNMELPHGG----------E--GW--Q---QLR----Q----GY-----LP---PEFT-----AGL----SSELRSVLVMMLEPDPKLR-----ATAEALLALPVLR------------------------------------------------------------------------------------------------------------------------------------
49 Fugue 68.5916% 6 - C1 - - 3C4Z RK_BOVIN A:[31-533] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQP---IGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQ--LFCSFLDAETVARARAGGLF----QPLLRAVLAHLGQAPFQEFLDSLYFL-RFLQW--KWLEAQPMGED----------WFLDFRVLGRGGFGEVFACQMKATGKLYACKK-LNKKRLKK-------RKGYQG-----AMVEKKILAKVHS-RFIVSLAYAFETK--TDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQR-NIIYRDLKPENVLL---DD--D---G----NVRISDLGLAVELKA-GQTKTKGYAGTPG-------------------------------------------------------------FMAPELLL------GEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKV------E--NK--E---LKQ----R----VL-----EQ--AVTYP-----DKF----SPASKDFCEALLQKDPEKR-----LGFRD-GSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNGAFSGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP-----------------------------------------------------
33 HHSearch 66.9924% -86 - C1 - - 4XBR INKA1_HUMAN (first) A:[93-350] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-------S----------YLDNFIKIGEGSTGIVCIATVRSSGKLVAVKK-M--DLRK--------QQRREL-----LFNEVVIMRDYQ-HENVVEMYNSYLVGD--ELWVVMEFLEGGALTDIVTHT-----RMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILL---TH--D---G----RVKLSDFGFCAQVSKEVP--------------------------------------------------------------RRKSLVGTPYWMAPELIS------RLP-YGPEVDIWSLGIMVIEMVDGEPPYFNE----------P--PL--KAMKMIR----D----NL-----PP--RLKNL-----HKV----SPSLKGFLDRLLVRDPAQR-----ATAAELLKHPFLAKA----------------------------------------------------------------------------------------------------------------------------------
40 HHSearch 65.3025% -87 - C1 - - 5TVT MELK_HUMAN A:[8-267] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-------K----------YYELHETIGTGGFAKVKLACHILTGEMVAIKI-M--DKNTL-------GSDLPR-----IKTEIEALKNLR-HQHICQLYHVLETAN--KIFMVLEYCPGGELFDYIISQ----DRLSEEETRVVFRQIVSAVAYVHSQ-GYAHRDLKPENLLF---DE--Y---H----KLKLIDFGLCAK--------------------------------------------------------------------------GSLAYAAPELIQ------GKSYLGSEADVWSMGILLYVLMCGFLPFDDD----------N--V---M---ALY----K----KIM----RG--KYDVP-----KWL----SPSSILLLQQMLQVDPKKR-----ISMKNLLNHPWIMQD----------------------------------------------------------------------------------------------------------------------------------
35 HHSearch 64.4825% -86 - C1 - - 5K00 MELK_HUMAN A:[6-265] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-------K----------YYELHETIGTG--AKVKLACHILTGEMVAIKI-M--DKNTL-------GSDLPR-----IKTEIEALKNLR-HQHICQLYHVLETAN--KIFMVLEYCPGGELFDYIISQ----DRLSEEETRVVFRQIVSAVAYVHSQ-GYAHRDLKPENLLF---DE--Y---H----KLKLIDFGLCAKP--------------------------------------------------------------------------SLAYAAPELIQ------GKSYLGSEADVWSMGILLYVLMCGFLPFDDD----------N--V---M---ALY----K----KIM----RG--KYDVP-----KWL----SPSSILLLQQMLQVDPKKR-----ISMKNLLNHPWIMQD----------------------------------------------------------------------------------------------------------------------------------
29 HHSearch 63.5028% -2 - C1 - - 2Y7J PHKG2_HUMAN C:[93-364] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-------Q----------KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKI-M--EVTAERLSPEQLEEVREA-----TRRETHILRQVAGHPHIITLIDSYESSS--FMFLVFDLMRKGELFDYLTEK----VALSEKETRSIMRSLLEAVSFLHAN-NIVHRDLKPENILL---DD--N---M----QIRLSDFGFSCHLEPGEK---------------------------------------------------------------LRELCGTPGYLAPEILKCSMDETHPG-YGKEVDLWACGVILFTLLAGSPPFWHR----------R--QI--L---MLRMIMEG----QY-----QF--SSPEW-----DDR----SSTVKDLISRLLQVDPEAR-----LTAEQALQHPFFE------------------------------------------------------------------------------------------------------------------------------------
48 Fugue 62.6317% 31 - C1 - - 2ACX GRK6_HUMAN A:[14-532] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KARKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERNPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRNLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFN-RFLQW--KWLERQPVTKN----------TFRQYRVLGKGGFGEVCACQVRATGKMYACKK-LEKKRIKK-------RKGEAM-----ALNEKQILEKVNS-RFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIY--HMGQAGFPEARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILL---DD--H---G----HIRISDLGLAVHVPEGQTIKGRV---------------------------------------------------------------GTVGYMAPEVVK------NER-YTFSPDWWALGCLLYEMIAGQSPFQQR----------K--KK--I---K-R----E----EV-----ER--LVKEVPEEYSERF----SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGS------------------------------------------------------------------
51 Fugue 62.3923% -42 - C1 - - 5KCV AKT1_HUMAN A:[20-452] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVKEGWLHKRGEYITWRPRYFLLKNDGT-FIGYKERPAPL---------NNFSVAQCQLMKTERPRPNTFIIRCLQ--WTTVIERTFH-----VETPEEREEWT-TAIQR--VTM-------N----------EFEYLKLLGKGTFGKVILVKEKATGRYYAMKI-L--K---------------KV-----LQNSRH--------PFLTALKYSFQTH--DRLCFVMEYANGGE----LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML---DK--D---G----HIKITDFG---LCPE---------------------------------------------------------------------------YLAPEVLE------DND-YGRAVDWWGLGVVMYEMMCGRLPFYNQ----------D--HE--K---LFE----L----IL-----ME--EIRFP-----RTL----GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH--------RFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF-----------------------------------------------------------------------------------------------
30 HHSearch 60.9728% 2 - C1 - - 2Y7J PHKG2_HUMAN D:[93-364] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-------Q----------KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKI-M--EV---RLSPEQLEEVREA-----TRRETHILRQVAGHPHIITLIDSYESSS--FMFLVFDLMRKGELFDYLTEK----VALSEKETRSIMRSLLEAVSFLHAN-NIVHRDLKPENILL---DD--N---M----QIRLSDFGFSCHLEPGEK---------------------------------------------------------------LRELCGTPGYLAPEILKCSMDETHPG-YGKEVDLWACGVILFTLLAGSPPFWHR----------R--QI--L---MLR----MIMEGQY-----QF--SSPEW-----DDR----SSTVKDLISRLLQVDPEAR-----LTAEQALQHPFFE------------------------------------------------------------------------------------------------------------------------------------
24 HHSearch 58.7723% -13 - C1 - - 3C0I CSKP_HUMAN A:[23-293] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------D----------VYELCEVIGKGPFSVVRRCINRETGQQFAVKI-V--DVAKFTSSP---GLSTED-----LKREASICHMLK-HPHIVELLETYSSDG--MLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDN-NIIHRDVKPHCVLL---AS--K---ENSA-PVKLGGFGVAIQLGESGL--------------------------------------------------------------VAGGRVGTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT----------K--ERLFE---GIIK---G----KY-----KM--NPRQW-----SHI----SESAKDLVRRMLMLDPAER-----ITVYEALNHPWLKER----------------------------------------------------------------------------------------------------------------------------------
23 HHSearch 57.8623% -14 * C1 * - 3C0G CSKP_HUMAN B:[23-293] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------D----------VYELCEVIGKGPFSVVRRCINRETGQQFAVKI-V--DVAKFTSSP---GLSTED-----LKREASICHMLK-HPHIVELLETYSSDG--MLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDN-NIIHRDVKPHCVLL---AS--KENSA----PVKLGGFGVAIQLGESGL--------------------------------------------------------------VAGGRVGTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT----------K--ERLFE---GIIK---G----KY-----KM--NPRQW-----SHI----SESAKDLVRRMLMLDPAER-----ITVYEALNHPWLKER----------------------------------------------------------------------------------------------------------------------------------
50 Fugue 57.3821% 11 - C1 - - 4XHG ? A:[2-397] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DL--RVG-------R----------KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLES--IRSRH-------PQLDYE-----SRVYKYLSGGV-GIPFIRWFG---REGEYNAMVIDL---LGPSLEDLFNY---CHRKFSFKTVIMLALQMICRVQYIHGR-SFIHRDIKPDNFLMGVGRR--G---S----TVHVIDFG---------------------LSKKYR----------DFNTHRHI------------------PYRENKSLT------GTARYASVNTHL------GIE-QSRRDDLESLGYMLIYFCKG-SLPWQGLKATTKKQKYD--RI--L---EKK----L----CI-----SV--ETLCA------GL----PLEFSEYMNYCRNLKFDER-----PD----YLYLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMVEKKNDSFNKVKLLAMKKFASHFHYCKNDDKHYPTPEEIKQQTVQNNNAAPELLSAIDK----------------------------------------------
41 HHSearch 56.2219% -66 - C1 - - 3CBL A:[113-370] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-------E----------DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS-C--RETLP-------PDLKAK-----FLQEARILKQYS-HPNIVRLIGVCTQKQ--PIYIVMELVQGGDFLTFLRTE---GARLRVKTLLQMVGDAAAGMEYLESK-CCIHRDLAARNCLV---TE--K---N----VLKISDFGMSREEADGVYA------------------------------------------------------------ASGGLRQVPVKWTAPEALN------YGR-YSSESDVWSFGILLWETFSLGASPYPN----------L--SN--Q---QTR----E----FV-----EKGGRLPCP-----ELC----PDAVFRLMEQCWAYEPGQR-----PSFSTIYQELQ--------------------------------------------------------------------------------------------------------------------------------------
37 HHSearch 55.8419% -63 - C1 - - 3BKB A:[113-370] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-------E----------DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS-C--RETLP-------PDLKAK-----FLQEARILKQYS-HPNIVRLIGVCTQKQ--PIYIVMELVQGGDFLTFLRTE---GARLRVKTLLQMVGDAAAGMEYLESK-CCIHRDLAARNCLV---TE--K---N----VLKISDFGMSREEADGVYA------------------------------------------------------------ASGGLRQVPVKWTAPEALN------YGR-YSSESDVWSFGILLWETFSLGASPYPN----------L--SN--Q---QTR----E----FV-----EKGGRLPCP-----ELC----PDAVFRLMEQCWAYEPGQR-----PSFSTIYQELQ--------------------------------------------------------------------------------------------------------------------------------------
31 HHSearch 54.4324% -66 - C1 - - 2X4F MYLK4_HUMAN A:[89-349] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y----------TVSKTEILG-----QVHKCEETATGLKLAAKI-I--KTRGM--------KDKEE-----VKNEISVMNQLD-HANLIQLYDAFESKN--DIVLVMEYVDGGELFDRIIDES---YNLTELDTILFMKQICEGIRHMHQM-YILHLDLKPENILCVN-RD--A---K----QIKIIDFGLARRYKPREK---------------------------------------------------------------LKVNFGTPEFLAPEVVN------YDF-VSFPTDMWSVGVIAYMLLSGLSPFLGD----------N--DA--E---TLN----NILACRW-----DL--EDEEF-----QDI----SEEAKEFISKLLIKEKSWR-----ISASEALKHPWLSDH----------------------------------------------------------------------------------------------------------------------------------
45 Fugue 51.3318% 6 - C1 - - 1KOB ? A:[23-374] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------INDYDKFYEDIWKKYVPQPVEVKQG--SVY-------D----------YYDILEELGSGAFGVVHRCVEKATGRVFVAKF-I--N-TPY-------PLDKYT-----VKNEISIMNQLHH-PKLINLHDAFEDK--YEMVLILEFLSGGELFDRIA---AEDYKMSEAEVINYMRQACEGLKHMHEH-SIVHLDIKPENIMCET-KK--A---S----SVKIIDFGLATKLNPDEI---------------------------------------------------------------VKVTTATAEFAAPEIVD------REP-VGFYTDMWAIGVLGYVLLSGLSPFAGE----------D--DL--E---TLQ----N----VK-----RC--DWEFD-----EDAFSSVSPEAKDFIKNLLQKEPRKR-----LTVHDALEHPWLKGD-------HSNLTSRIPSSRYNKIRQKIKEKYADWPAPQPAIGRIANFSSLRKHRPQEYQIYDSYFDRKEA------------------------------------------------------------
26 HHSearch 50.9221% -58 - C1 - - 1TKI - TITIN_HUMAN A:[20-281] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LY-------E----------KYMIAEDLGRGEFGIVHRCVETSSKKTYMAKF-V--KVKG---------TDQVL-----VKKEISILNIAR-HRNILHLHESFESME--ELVMIFEFISGLDIFERINTS---AFELNEREIVSYVHQVCEALQFLHSH-NIGHFDIRPENIIY---QTRRS---S----TIKIIEFGQARQLKPGDN---------------------------------------------------------------FRLLFTAPEYYAPEVHQ------HDV-VSTATDMWSLGTLVYVLLSGINPFLAE----------T--NQ--Q---IIE----NIMNAEY-----TF--DEEAF-----KEI----SIEAMDFVDRLLVKERKSR-----MTASEALQHPWLKQK----------------------------------------------------------------------------------------------------------------------------------
32 HHSearch 50.0622% -49 - C1 - - 4NIF - KS6A1_HUMAN A:[6-269] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FS-------D----------GYVVKETIGVGSYSECKRCVHKATNMEYAVKV-I--DKSK------------RD-----PSEEIEILLRYGQHPNIITLKDVYDDGK--HVYLVTELMRGGELLDKILRQ----KFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILY---VD--E---SGNPECLRICDFGFAKQLRAENG--------------------------------------------------------------LLMTPCY---FVAPEVLK------RQG-YDEGCDIWSLGILLYTMLAGYTPFANG----------PSDTP--E---EIL----T----RIGSGKFTL--SGGNW-----NTV----SETAKDLVSKMLHVDPHQR-----LTAKQVLQHPWVTQ-----------------------------------------------------------------------------------------------------------------------------------
46 Fugue 49.8718% -33 - C1 - - 1TKI - TITIN_HUMAN A:[18-338] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K--ELY-------E----------KYMIAEDLGRGEFGIVHRCVETSSKKTYMAKF-V--K--VK-------GTDQVL-----VKKEISILNIARH-RNILHLHESFESM--EELVMIFEFISGLDIFERINTS---AFELNEREIVSYVHQVCEALQFLHSH-NIGHFDIRPENIIYQT-RR--S---S----TIKIIEFGQARQLKPG---------------------------------------------------------------DNFRLLFTAPEYYAPEVHQ------HDV-VSTATDMWSLGTLVYVLLSGINPFLAE----------T--NQ--Q---IIE----N----IMNAEY-TF--DEEAF-----KEI----SIEAMDFVDRLLVKERKSR-----MTASEALQHPWLKQKIERVSTKV------IRTLKHRRYYHTLIKKDLNMVVSAARISCGGAIRSQKGVSVAKVKVASI-------------------------------------------------------------------
16 PsiBlast_PDB 40.9233% -53 - C1 - - 4YVC ROCK1_HUMAN A:[74-243] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIK-F----FWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 39.7231% 10 - C1 - - 4L6Q ROCK2_HUMAN A:[24-240] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPINVESLLDG--LNSLVLDLDFPAL------RKNKNID-NFLNRYEKIV-------KKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSM-GLIHRDVKPDNMLL---DK--H---G----HLKLADFGTCMKMDETGMVHCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 35.2130% 14 - C1 - - 2F2U ROCK2_BOVIN A:[12-242] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRKLEALIRDPRSPINVESLLDG--LNSLVLDLDFPAL------RKNKNID-NFLNRYEKIV-------KKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFCAFQDDKY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSM-GLIHRDVKPDNMLL---DK--H---G----HLKLADFGTCMKMDETGMVHCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 34.8830% 9 - C1 - - 2H9V ROCK2_BOVIN A:[10-247] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRQRKLEALIRDPRSPINVESLLDG--LNSLVLDLDFPAL------RKNKNID-NFLNRYEKIV-------KKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFCAFQDDKY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSM-GLIHRDVKPDNMLL---DK--H---G----HLKLADFGTCMKMDETGMVHCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12 PsiBlast_PDB 34.5033% -1 - C1 - - 2ETR ROCK1_HUMAN A:[74-236] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20 PsiBlast_PDB 33.7033% -1 - C1 - - 5KKS ROCK1_HUMAN A:[74-241] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19 PsiBlast_PDB 33.2033% -5 - C1 - - 5HVU ROCK1_HUMAN A:[74-242] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 PsiBlast_PDB 33.1433% 2 - C1 - - 2ESM ROCK1_HUMAN A:[74-236] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 PsiBlast_PDB 33.1233% 2 - C1 - - 2ETK ROCK1_HUMAN A:[74-236] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17 PsiBlast_PDB 33.0033% -2 - C1 - - 4YVE ROCK1_HUMAN A:[74-246] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18 PsiBlast_PDB 32.3833% -2 - C1 - - 5BML ROCK1_HUMAN A:[74-243] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13 PsiBlast_PDB 31.7533% 2 - C1 - - 3D9V ROCK1_HUMAN A:[74-236] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKL------LSK-------FEMIKRSDSAFFWEERDIMAFANS-PWVVQLFYAFQDDRY--LYMVMEYMPGGDLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHSM-GFIHRDVKPDNMLL---DK--S---G----HLKLADFGTCMKMNKEGMVRCDTAVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------