@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MRK1: (2018-07-14 )
MTGRFTRPQWSLATGRHYASSGHSAASSCSTHTLKVNQTESYRPGPDDSGTYSANLRDSPSRTMSNTSVSVSPMDSSSPQEWGRSFRLFNSCRFLTSASGSRQRDGSIGQLYRSTFLHGRQGRGSSVGPEAERPLLGSSMIHQPQSSFFGAFSGQGGRYSFWPPDVNASGVLTAASPYAASNPSAPLSTASPLLGSSRFLGTGISPRGLADGHAVHRVVASCAMGSVVCTVSPGQNELPLAMNALRTHLALRGKTIIQGDAAHPLEIRKGPLIGAGGFAKVFAGVDTVRGELVAIKEIDISGVDDVKALNAIEAEFALLKSLHHPNIVSYSLFEHSKSQKVCRIAMELLAGDSTLHLLQKFGPLTEAVLRIVARSVLRAIRFIHKEGIFHRDIKPANILVSHRGEVKLCDFGCSKRVSELNKAASCIIGTPVYMAPEFIKGEANHKADIWSMACALFELSTGLLPWYHSGVKDNLPLMFYITTTSESPMVLPSPEAKSEFSAEFLSFMELCFTRNVANRPEADDLLKHPWITGSRLAPVPNLPSAVLSLHQESSAVFRAFGSPGKSSTFSSPRDSAADRDDMSFNGSDGLQKSVSTTPTLNPAEEEMACQQELETVAAATALELCSLLVCSLEIPPRTAQETVTGEVGSGTGDTSPSLTRTFSIHSPALSHRGGGVSASVAEFLSPVYTPEHSMVHENFYYSQVPLGASAGNFVLPPGLDLDGAPPQQQYLRINEEGNLDMVYLPGDEMEDSVHGRSTFGDSVYGSFHAGRIVSPARNSSFSRGTLSPRVAAGPNTVGVADGPFSPLLGISGVFSRRESPSRGGPSVPSSPQGIPAPPLLYRPGPSTTFVSQPSSHTGSMHTSHVSPTSTSKAGSNVDAATPHTPRSNSPTSTQRSESFRGLPEKLKTHADGKLHMSFSVNTAPGCAVNVELNVDVADVQCKVVDNQPNFVVAFTDDVRSQIANKIKEVAEHSSSGKPAQTAGTHASSLSPLCGMEARRSVSAGGGHFYNSPLFAAASKATPRPLSRVSTGSAQRLVAVPREALAGYSSYSGEEGSDVDSHTSSPVTAGWNERVGK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....-..270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......----440---..-......450.......460.......470.....--..480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTGRFTRPQWSLATGRHYASSGHSAASSC
S
T
H
T
L
K
VNQTESYRPGPDDSG
T
Y
SANLRDSPSRTMSN
T
S
V
S
V
SPMDSS
S
P
Q
E
W
G
R
S
F
R
L
F
N
S
C
R
F
L
TSASGSRQRDG
S
I
G
Q
L
Y
R
S
T
FLHGRQGRGSSVGPEAERPLL
G
S
S
M
IHQP
Q
S
S
FFGAFSGQGGRYSFWPPDVNASG
V
L
TAASPYAASNPSAPLSTASPLLGSSRFLGTGISPRGLAD
G
H
A
V
H
R
V
V
A
S
CAM
G
S
V
V
C
T
VSPGQNEL
P
L
A
M
N
A
L
R
T
H
L
ALRG
K
T
I
IQGDAAH
P
L
E
I-RKG
P
L
IGA
G
G
F
A
K
V
F
A
G
V
D
TVRG
E
L
V
A
I
K
E
IDISGV
D
D
V
K
A
L
N
A
I
E
A
E
F
A
L
L
K
S
LHHPNIV
S
Y
S
L
F
EHSK
S
Q
K
V
C
R
I
A
M
E
L
LAG
D
S
T
L
H
L
L
Q
KF
G
P
L
T
E
A
V
L
R
I
V
A
R
S
V
L
R
A
I
R
F
I
H
KEGIFHRDIKPA
N
I
L
V
SHRG
E
V
K
L
CDFG
C
S
K
R
V
S
E
L
N
K
A
A
S
CIIGTPVYMA
P
E
F
I----KG----EA-NHK
A
D
I
W
S
M
A
C
A
L
F
E
L
S
T
G
L
L
P
W
Y
HSGVKDNL
P
L
--
M
F
Y
I
TTTSES
P
M
VLPSPEA
K
S
E
F
S
A
E
F
L
S
F
M
E
L
C
F
TRNVANRP
E
A
D
D
L
L
KHPWITGSRLAPVPNL
P
S
A
V
L
S
L
H
Q
ES
S
A
V
F
R
AFGSPGKSSTFSSPRDSAADRDDMSFNGSDGLQKSVSTTPTLN
P
A
E
E
E
M
A
C
Q
Q
E
L
E
T
V
A
A
A
T
A
L
E
L
C
S
L
L
V
C
SLEIPPRTAQETVTGEVGSGTGDTSPS
L
T
R
T
F
S
IHSPALSHRGGGV
S
A
S
V
A
E
F
L
S
P
VYTPEH
S
M
V
H
EN
F
Y
YSQVPLGASAG
N
F
VLPPGLDLDGAP
P
Q
Q
Q
Y
L
R
INEEG
N
L
D
M
V
Y
LPGDEM
E
D
SVHGRSTFGDSVYGSFHAGRIVSPARNSSFSRGTLSPRVAAGPNTVGVADGPFS
P
L
L
G
I
S
G
V
FSRRESPSRGGPSVPSSPQGIPAPP
L
L
YRPGPST
T
F
V
SQPSSHTGSMHTSHVSPTSTSKAGSNVDAATPHTPRSNSPTST
Q
R
S
E
S
F
RG
L
P
E
K
L
K
THAD
G
K
L
H
M
S
F
SVNTAPG
C
A
V
N
V
E
L
N
V
D
V
A
D
V
Q
C
K
V
VDNQP
N
F
V
V
A
F
T
D
D
V
R
S
Q
I
A
N
K
I
K
E
V
A
E
HSSSGKPAQTAGTHASSLSPLC
G
M
E
A
RRSVSAGGGHFYNS
P
L
F
AAASKATPRP
L
S
RVSTGSA
Q
R
L
V
AV
P
R
E
A
LAGYSSYSGEEGSDVDSHTSSPVTAGWNERVGK
1
PsiBlast_PDB
74.67
36%
-69
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[27-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
-
F
G
S
Y
L
K
S
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-----
N
S
D
L
H
P
M
--
R
V
L
F
L
I
P
K
N
S
P
-----
P
T
L
E
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.37
35%
-63
- C1 -
-
4O27
1
STK24_HUMAN
B:
[14-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
72.12
28%
-95
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
-
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
---
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
----
S
R
----
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
---
A
--
M
K
M
I
R
D
N
L
P
-
P
----
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.06
35%
-14
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.39
35%
-19
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.31
35%
-13
- C1 -
-
4QMQ
3
STK24_HUMAN
A:
[20-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.10
35%
-14
- C1 -
-
4W8E
1
STK24_HUMAN
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.87
35%
-65
- C1 -
-
3CKX
1
STK24_HUMAN
A:
[15-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.67
35%
-14
- C1 -
-
4QMM
3
STK24_HUMAN
A:
[20-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.34
36%
-87
- C1 -
-
4NZW
1
STK25_HUMAN
B:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
-
F
G
S
Y
L
K
S
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
--------------
T
P
F
W
M
A
P
E
V
I
----
K
Q
------Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-----
N
S
D
L
H
P
M
--
R
V
L
F
L
I
P
K
N
S
P
-----
P
T
L
E
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.19
35%
-12
- C1 -
-
4QML
2
STK24_HUMAN
A:
[25-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.13
35%
-13
- C1 -
-
4QMO
4
STK24_HUMAN
A:
[20-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.06
35%
-14
- C1 -
-
4QMP
2
STK24_HUMAN
A:
[20-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.04
35%
-13
- C1 -
-
3A7I
1
STK24_HUMAN
A:
[13-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.69
35%
-70
- C1 -
-
3ZHP
-
STK24_HUMAN
C:
[35-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.47
35%
-14
- C1 -
-
3A7J
1
STK24_HUMAN
A:
[13-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.28
35%
-12
- C1 -
-
3A7H
1
STK24_HUMAN
A:
[13-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
68.66
31%
-84
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
-
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
--
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
----
A
V
ERKG
G
Y
-
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
---
A
--
L
F
L
M
T
K
S
N
F
Q
P
---
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.29
33%
-97
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[12-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
E
D
---
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
--
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER
K
G
----
G
Y
-
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
-----
D
L
H
P
M
R
A
L
F
L
M
T
K
S
N
F
Q
P
---
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.21
35%
-13
- C1 -
-
3A7F
-
STK24_HUMAN
A:
[13-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.34
35%
-11
- C1 -
-
4QMN
1
STK24_HUMAN
A:
[22-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
-
Y
G
S
Y
L
K
D
T
K
L
W
-
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
Q
----
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
--
H
S
E
L
H
---
P
M
--
K
V
L
F
L
I
P
K
N
N
P
-----
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------