@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKC3: (2017-10-26 )
MKKVVVFSQIDEEILSRLQQDYHVVVLNPKLGDINEQIRQEVVDADGMIGAGRLLNESNLSPAQKLKIISSVTVGYDNYDVGYLNQKKIWLANTPHVLTETTADLAFTLLLSAARKVPFLDHWTKQGEWKRTVGPQQFGLDVFGKTLGIIGLGNIGAAIARRGFYGFNMNIVYHNRREKPELAEPLKAQYLGLEELLQQSDFVVTAVGLNAESKALMGKAQFELMQKHAIFINIARGSVVDEQALIEALQNEVIFAAGLDVYEKEPLQESALFNLPNVVTLPHVGSATAETRKKMANLAYKNLVEALEDKTPRYLVNPNFV
Atome Classification :
(33 SA)
.........10........20........30........40........50-........60........70........80........90........100.......110.......120.......130--...----....-.140.......150.......160.......-170.......180.......190........200.......210.......220.......230.......240.......250.......260.......270........280.......290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
K
V
V
V
F
S
QI
D
E
E
I
L
S
R
L
QQD
Y
H
V
V
V
LNPKLG
D
I
N
E
Q
I
R
Q
E
V
VDADGMIGA-GRLLNESNL
S
P
A
Q
K
L
K
I
I
S
S
V
T
VGYDNYDVG
Y
L
N
Q
K
K
I
W
LANTP
H
V
L
T
E
T
T
A
D
L
A
F
T
L
L
L
S
A
A
RKVP
F
L
D
HWTKQGEWKR---TV
G
----
P
Q
Q
F
-
G
L
D
V
F
G
K
T
L
GIIGLG
N
I
G
A
A
I
A
RRGFYGFN
M
-
N
I
V
Y
HNRREK
P
E
L
A
E
P
L
K
A
Q
Y
L
-
G
L
E
E
L
L
QQS
D
F
V
V
T
A
VGLNA
E
S
K
A
L
M
G
K
A
Q
F
E
L
M
Q
K
H
A
I
F
I
N
IARGSVV
D
E
Q
A
L
I
E
A
L
QN
E
V
I
F
AAGLDVYEKEPL
Q
E
S
-ALFNLP
N
V
V
TLPHVGS
A
T
A
E
T
R
K
K
M
A
N
L
A
Y
K
N
L
V
E
A
L
EDKTP
R
Y
LVNPNFV
2
PsiBlast_PDB
78.72
42%
-0
* C2 *
-
5AOW
8
?
A:
[4-322]
--
K
V
L
I
T
R
A
I
P
E
N
G
I
E
L
L
R
E
H
F
E
V
E
V
W
E
H
E
H
E
I
P
R
E
V
L
L
E
K
V
K
D
V
D
A
L
V
T
M
L
S
E
K
I
D
R
E
V
F
D
A
A
P
R
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
W
A
L
L
L
A
A
A
R
H
V
V
K
G
D
K
F
V
R
S
G
E
W
K
R
R
GI
A
W
H
----
P
K
M
F
L
G
Y
D
V
Y
G
K
T
I
G
I
V
G
F
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
G
M
-
R
I
L
Y
T
A
R
S
R
K
P
E
A
E
K
E
L
G
A
E
F
K
-
P
L
E
E
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
K
E
T
Y
H
M
I
N
E
E
R
L
R
L
M
K
P
T
A
V
L
V
N
V
A
R
G
K
V
V
D
T
K
A
L
I
R
A
L
K
E
G
W
I
A
A
A
G
L
D
V
F
E
E
E
P
Y
Y
D
E
-
E
L
F
A
L
D
N
V
V
L
T
P
H
I
G
S
A
T
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
N
G
E
V
P
P
T
L
V
N
----
101
HHSearch
77.62
42%
3
- C2 -
-
5AOW
8
?
A:
[2-325]
K
P
K
V
L
I
T
R
A
I
P
E
N
G
I
E
L
L
R
E
H
F
E
V
E
V
W
E
H
E
H
E
I
P
R
E
V
L
L
E
K
V
K
D
V
D
A
L
V
T
M
L
S
E
K
I
D
R
E
V
F
D
A
A
P
R
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
W
A
L
L
L
A
A
A
R
H
V
V
K
G
D
K
F
V
R
S
G
E
W
K
R
---
R
G
I
AWHP
K
M
F
L
-
G
Y
D
V
Y
G
K
T
I
G
I
V
G
F
G
R
I
G
Q
A
I
A
K
R
A
K
-
G
F
G
M
-
R
I
L
Y
T
A
R
S
R
K
P
E
A
E
K
E
L
G
A
E
F
K
-
P
L
E
E
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
K
E
T
Y
H
M
I
N
E
E
R
L
R
L
M
K
P
T
A
V
L
V
N
V
A
R
G
K
V
V
D
T
K
A
L
I
R
A
L
K
E
G
W
I
A
A
A
G
L
D
V
F
E
E
E
P
Y
Y
D
E
-
E
L
F
A
L
D
N
V
V
L
T
P
H
I
G
S
A
T
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
N
G
E
V
P
P
T
L
V
N
R
E
V
-
3
PsiBlast_PDB
77.00
43%
0
- C2 -
-
2DBR
1
GYAR_PYRHO
A:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
GV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
22
PsiBlast_CBE
76.98
43%
-2
- C2 -
-
2DBZ
1
GYAR_PYRHO
B:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
RGV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
23
PsiBlast_CBE
76.63
43%
5
- C2 -
-
2DBR
1
GYAR_PYRHO
F:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
RGV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
26
PsiBlast_CBE
76.58
43%
2
- C2 -
-
2DBR
2
GYAR_PYRHO
C:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
RGV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
25
PsiBlast_CBE
76.53
43%
1
- C2 -
-
2DBR
1
GYAR_PYRHO
D:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
RGV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
21
PsiBlast_CBE
76.51
42%
0
- C2 -
-
5AOW
6
?
B:
[4-322]
--
K
V
L
I
T
R
A
I
P
E
N
G
I
E
L
L
R
E
H
F
E
V
E
V
W
E
H
E
H
E
I
P
R
E
V
L
L
E
K
V
K
D
V
D
A
L
V
T
M
L
S
E
K
I
D
R
E
V
F
D
A
A
P
R
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
W
A
L
L
L
A
A
A
R
H
V
V
K
G
D
K
F
V
R
S
G
E
W
K
R
R
GI
A
W
H
----
P
K
M
F
L
G
Y
D
V
Y
G
K
T
I
G
I
V
G
F
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
G
M
-
R
I
L
Y
T
A
R
S
R
K
P
E
A
E
K
E
L
G
A
E
F
K
-
P
L
E
E
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
K
E
T
Y
H
M
I
N
E
E
R
L
R
L
M
K
P
T
A
V
L
V
N
V
A
R
G
K
V
V
D
T
K
A
L
I
R
A
L
K
E
G
W
I
A
A
A
G
L
D
V
F
E
E
E
P
Y
Y
D
E
-
E
L
F
A
L
D
N
V
V
L
T
P
H
I
G
S
A
T
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
N
G
E
V
P
P
T
L
V
N
----
27
PsiBlast_CBE
76.47
43%
2
- C2 -
-
2DBR
1
GYAR_PYRHO
B:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
RGV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
24
PsiBlast_CBE
76.44
43%
-4
- C2 -
-
2DBR
1
GYAR_PYRHO
E:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
RGV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
4
PsiBlast_PDB
76.02
43%
-0
- C2 -
-
2DBZ
1
GYAR_PYRHO
A:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
GV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
90
HHSearch
75.84
41%
0
- C2 -
-
5AOV
24
GYAR_PYRFU
A:
[2-326]
K
P
K
V
F
I
T
R
A
I
P
E
N
G
I
N
M
L
E
E
E
F
E
V
E
V
W
E
E
E
R
E
I
P
R
E
K
L
L
E
K
V
K
D
V
D
A
L
V
T
M
L
S
E
R
I
D
Q
E
V
F
E
N
A
P
R
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
V
E
E
A
T
R
R
G
I
Y
V
T
N
T
P
D
V
L
T
N
A
T
A
D
H
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
K
F
V
R
S
G
E
W
K
R
---
K
G
I
AWHP
K
W
F
L
-
G
Y
E
L
Y
G
K
T
I
G
I
V
G
F
G
R
I
G
Q
A
I
A
R
R
A
K
-
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
S
Q
A
E
K
E
L
G
A
E
Y
R
-
P
L
E
E
V
L
K
E
S
D
F
V
I
L
A
V
P
L
T
K
E
T
M
Y
M
I
N
E
E
R
L
K
L
M
K
P
T
A
I
L
V
N
I
A
R
G
K
V
V
D
T
K
A
L
I
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
S
L
D
N
V
V
L
T
P
H
I
G
S
A
T
F
E
A
R
E
A
M
A
E
L
V
A
R
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
K
E
V
I
5
PsiBlast_PDB
73.96
42%
1
- C2 -
-
2DBQ
6
GYAR_PYRHO
A:
[4-322]
--
K
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
GV
A
W
H
----
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
----
106
HHSearch
72.66
34%
-100
- C2 -
-
5V7N
2
?
C:
[4-314]
R
P
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
---
D
A
A
L
V
T
A
D
M
R
D
V
S
G
I
A
V
S
--
G
K
L
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
L
E
-
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
----
L
G
F
T
Y
H
P
T
L
V
G
M
A
E
A
V
D
T
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
K
A
W
F
S
T
G
E
A
L
T
P
V
A
E
T
--
31
PsiBlast_CBE
70.67
41%
-95
- C2 -
-
2GCG
2
GRHPR_HUMAN
C:
[77-319]
------------------------------------------------------------------
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
S
---
W
K
P
----
L
W
L
C
-
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
-
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
E
F
Q
A
E
F
V
-
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
--------------
42
PsiBlast_CBE
70.52
35%
-142
- C2 -
-
5J23
1
?
D:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
44
PsiBlast_CBE
70.35
35%
-142
- C2 -
-
5J23
1
?
B:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
11
PsiBlast_PDB
70.10
40%
-151
- C2 -
-
3BAZ
1
HPPR_PLESU
A:
[87-319]
-----------------------------------------------------------------
K
L
E
I
V
S
S
F
S
V
G
L
D
K
V
D
L
I
K
C
E
E
K
G
V
R
V
T
N
T
P
D
V
L
T
D
D
V
A
D
L
A
I
G
L
I
L
A
V
L
R
R
I
C
E
C
D
K
Y
V
R
R
G
A
W
K
-----
F
G
----
D
F
K
L
-
T
T
K
F
S
G
K
R
V
G
I
I
G
L
G
R
I
G
L
A
V
A
E
R
A
-
E
A
F
D
C
-
P
I
S
Y
F
S
R
S
K
K
P
N
T
N
---
Y
T
Y
Y
G
-
S
V
V
E
L
A
S
N
S
D
I
L
V
V
A
C
P
L
T
P
E
T
T
H
I
I
N
R
E
V
I
D
A
L
G
P
K
G
V
L
I
N
I
G
R
G
P
H
V
D
E
P
E
L
V
S
A
L
V
E
G
R
L
G
G
A
G
L
D
V
F
E
R
E
P
E
V
P
E
-
K
L
F
G
L
E
N
V
V
L
L
P
H
V
G
S
G
T
V
E
T
R
K
V
M
A
D
L
V
V
G
N
L
------------------
12
PsiBlast_PDB
69.87
35%
-142
- C2 -
-
5J23
1
?
A:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
14
PsiBlast_PDB
69.81
35%
-143
- C2 -
-
5V7G
3
?
A:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
17
PsiBlast_PDB
69.19
35%
-148
- C2 -
-
5V72
1
?
A:
[5-297]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
---
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
6
PsiBlast_PDB
69.06
41%
-91
- C2 -
-
2GCG
2
GRHPR_HUMAN
A:
[77-319]
------------------------------------------------------------------
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
S
---
W
K
P
----
L
W
L
C
-
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
-
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
E
F
Q
A
E
F
V
-
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
--------------
15
PsiBlast_PDB
68.86
35%
-141
- C2 -
-
5V7N
5
?
A:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
39
PsiBlast_CBE
68.26
35%
-140
- C2 -
-
5V6Q
2
?
D:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
32
PsiBlast_CBE
68.01
41%
-91
- C2 -
-
2GCG
2
GRHPR_HUMAN
B:
[77-319]
------------------------------------------------------------------
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
V
K
N
G
G
W
T
S
---
W
K
P
----
L
W
L
C
-
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
-
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
E
F
Q
A
E
F
V
-
S
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
L
P
T
N
H
P
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
--------------
50
PsiBlast_CBE
67.96
41%
-145
- C2 -
-
2CUK
1
?
C:
[63-306]
---------------------------------------------------------------
A
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
K
A
---
W
H
P
----
E
L
L
L
-
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
-
A
F
G
M
-
R
V
V
Y
H
A
R
T
P
K
-----
P
L
P
Y
P
F
L
-
S
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
G
H
-
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
G
H
P
L
Y
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
---------
41
PsiBlast_CBE
67.85
35%
-141
- C2 -
-
5V6Q
2
?
B:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
34
PsiBlast_CBE
67.80
35%
-141
- C2 -
-
5V7N
2
?
C:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
13
PsiBlast_PDB
67.73
35%
-140
- C2 -
-
5V6Q
2
?
A:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
1
PsiBlast_PDB
67.72
43%
16
- C2 -
-
5AOV
23
GYAR_PYRFU
A:
[37-326]
-----------------------------------
E
K
L
L
E
K
V
K
D
V
D
A
L
V
T
M
L
S
E
R
I
D
Q
E
V
F
E
N
A
P
R
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
V
E
E
A
T
R
R
G
I
Y
V
T
N
T
P
D
V
L
T
N
A
T
A
D
H
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
K
F
V
R
S
G
E
W
K
R
K
GI
A
W
H
----
P
K
W
F
L
G
Y
E
L
Y
G
K
T
I
G
I
V
G
F
G
R
I
G
Q
A
I
A
R
R
A
-
K
G
F
N
M
-
R
I
L
Y
Y
S
R
T
R
K
S
Q
A
E
K
E
L
G
A
E
Y
R
-
P
L
E
E
V
L
K
E
S
D
F
V
I
L
A
V
P
L
T
K
E
T
M
Y
M
I
N
E
E
R
L
K
L
M
K
P
T
A
I
L
V
N
I
A
R
G
K
V
V
D
T
K
A
L
I
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
Y
Y
N
E
-
E
L
F
S
L
D
N
V
V
L
T
P
H
I
G
S
A
T
F
E
A
R
E
A
M
A
E
L
V
A
R
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
K
E
V
I
40
PsiBlast_CBE
67.58
35%
-141
- C2 -
-
5V6Q
2
?
C:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
35
PsiBlast_CBE
67.22
35%
-139
- C2 -
-
5V7N
4
?
B:
[6-298]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------
47
PsiBlast_CBE
67.20
35%
-143
- C2 -
-
5V72
1
?
C:
[5-297]
--
R
I
L
V
P
G
K
I
N
P
R
V
L
E
R
L
P
E
M
F
E
T
V
R
I
E
R
A
D
A
A
L
---
V
T
A
D
M
R
D
V
S
G
I
A
V
S
-
G
K
L
-
P
V
P
L
M
D
A
F
P
S
L
E
I
V
A
N
F
G
V
G
Y
D
G
V
D
V
S
R
A
A
A
R
G
I
V
V
T
N
T
P
D
V
L
T
E
E
V
A
D
T
A
I
G
L
L
L
N
T
L
R
L
L
P
Q
A
E
Q
W
L
R
Q
G
R
W
V
R
---
E
G
A
----
F
P
L
S
-
P
L
S
L
R
G
R
T
V
G
L
F
G
L
G
R
I
G
L
A
I
A
R
R
-
L
E
A
F
G
V
-
S
I
A
Y
H
T
R
T
P
R
E
G
L
G
F
T
Y
H
P
T
L
V
-
G
M
A
E
A
V
D
T
--
L
I
V
I
V
P
G
T
A
S
T
L
K
A
V
N
A
D
V
L
S
A
L
G
P
K
-
G
V
L
I
N
V
G
R
G
S
T
V
D
E
A
A
L
V
T
A
L
Q
N
G
T
I
A
G
A
G
L
D
V
F
E
N
E
P
N
V
P
E
-
A
L
L
S
F
P
N
V
S
L
L
P
H
V
A
S
A
S
V
V
T
R
N
A
M
S
D
L
V
V
D
N
L
------------------