@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKN4: (2017-10-27 )
MAKYSNINSFNALQTLTVGSSNYQIFSLTQAEKKLGDIAKLPKSLKVLLENLLRFEDQHSVKTEHIYALAEWLKTRTSDQEIQYRPARVLMQDFTGVPAVVDLAAMRAAMAQAGGDPEKINPLSPVDLVIDHSVMVDHFADDQAFEENVQIEMQRNGERYQFLRWGQSAFNNFSVVPPGTGICHQVNLEYLAQAVWLGEDNGQTFAFPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISMLIPEVIGFKLTGKLQEGITATDLVLTITQMLRQKGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGFFPIDEVTLGYLKLTGRQSDRIALVEAYSKAQGLWRNAGDEPVFTDTLSLDMSTVQASLAGPKRPQDRVLLSEVPKTFNALMELTLKPAKEAKERLENEGGGGTAVEATKANIQHESPSCVIEGQEYPLNHGDVVISAITSCTNTSNPSVMLAAGLLAKKAIEKGLQRKPWVKSSLAPGSKVVTDYLLAAGLTPYLDELGYNLVGYGCTTCIGNSGPLPEPIEDAIQCHDLNVASVLSGNRNFEGRVHPLVKTNWLASPPLVVAYGLVGNIRTDLTTQPIGQGKDGQPVYLKDIWPSQAEIDAVLQKVNTDMFHKEYAAVFDGDESWQAIQIPKSKTYEWADDSTYIRHPPFFEGIGEPPKPIKNIEQARILAVLGDSVTTDHISPAGNIKKDSLAGRYLQEQGVEPKDFNSYGSRRGNHEVMMRGTFANIRIKNEMLGGEEGGNTIHVPSGEKLAIYDAAMRYQHEHTPLVIIAGKEYGTGSSRDWAAKGTNLLGVKAVIAESFERIHRSNLVGMGVLPLQFVDGQTRQSLNLTGHEVISIRGLSDGIQPHEILEVDVKGPNGVASHFNVLCRIDTLNEVEYFKAGGILHYVLRNLIAS
Atome Classification :
(20 SA)
.........10-........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.-......150.......160..-.....170.......180.......190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....---..---.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530..--..-...540.......550.......560.....-..570-.......580.......590.......600.......610.-......620-..-.....630.......640.......650........660.......670.......680.......690.......700.......710.......720.......730.......740...-.-...750......-----.760.......770..-.....780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......--.900.......910......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAKYSNINSFN-
A
L
Q
T
L
T
VGSSN
Y
Q
I
F
S
L
T
Q
A
E
K
K
L
G
D
I
A
K
L
P
K
S
L
K
V
L
L
E
N
L
L
R
F
E
D
QHS
V
K
T
E
H
I
Y
A
L
A
E
W
L
K
TRTSDQEIQY
R
P
A
R
V
L
M
Q
DFTG
V
P
A
V
V
D
L
A
A
M
R
A
A
M
A
QAGGDPEKINPLS
P
V
D
L
V
IDH
S
V
M
V
D
HFAD
D
Q
-
A
FEE
N
V
Q
I
E
M
QRNGE
R
Y
Q
F
L
R-W
G
Q
S
AFNN
F
S
VVPPGTGI
C
H
QV
N
L
E
Y
L
A
Q
A
V
W
LGEDNG
Q
T
F
AFPDTL-VGTDSH
T
T
M
I
NG
L
G
V
L
GWGVGG
I
E
A
E
A
A
MLGQ
P
I
S
M
L
I
P
E
VI
G
F
K
L
T
G
K
L
QEGI
T
A
T
D
L
V
L
T
I
T
Q
M
L
R
QKGV
V
G
K
F
V
E
F
YGDGLADLPLA
D
R
A
T
I
A
NMAPEYGATCGFF
P
I
D
E
V
T
L
G
Y
L
K
LTGRQSDR
I
A
L
V
E
A
Y
S
K
A
Q
G
L
W
RNA---GD---EP
V
F
T
D
T
LSL
D
M
S
T
V
Q
A
SLAGPKRPQ
D
R
V
L
L
S
E
V
P
K
T
F
N
A
L
M
E
L
TLK
P
A
K
E
A
K
E
R
L
ENEGGGG
T
A
V
E
A
T
KANIQHESP
S
C
V
I
EGQEYPLNH
G
D
V
V
I
S
A
I
T
S
CTNTSNP
S
V
M
L
A
A
G
L
L
A
K
K
A
I
E
K
G
LQRKPWVKSSLAPG
S
K
V
V
T
D
Y
L
L
AAG
L
T
P
Y
L
D
E
LGYNLVGYGCTTCIGNSG--PL-P
E
P
I
E
D
A
I
Q
CHDL
N
V
A
S
V
LSGNRNFEG
R
V
H
P
-
L
V
KTN-WLASPP
L
V
V
A
YGLVGNIRTDLTTQPIGQGKDGQ
P
V
Y
L
KDIW-PS
Q
A
E
I
D
A
V
-
L
Q
-
K
V
N
T
D
M
F
H
K
E
Y
A
AVFDGDES
W
Q
A
I
QI-PKSKTYEWADDSTYIRHP
P
F
F
EGIGEPPK
P
I
K
N
I
E
Q
A
R
I
L
A
V
LGDSVTTDHISPAGNI
K
K
D
S
L
A
G
R
Y
L
Q
EQGVEPKD
F
N
S
Y
GSRRGN
H
E
V
M
M
R
G
T
-
F
-
A
N
I
R
I
K
NEMLGG-----EEGG
N
T
I
HVPSG
E
K
L
A
-
I
Y
D
A
A
M
R
YQHEHT
P
L
V
I
I
AGKEYGTGSSRDWAAKGT
N
L
L
G
V
K
A
V
I
A
E
S
F
E
R
I
H
R
SNLVGM
G
V
L
P
L
Q
FVDGQTR
Q
S
LNLTG
H
E
V
I
S
I
RGLSDGIQP
H
E
I
L
E
V
D
VKGPN
G
V
A
S
H
F
N
V
L
C
-
R
IDTLN
E
--
V
E
Y
F
KAG
G
I
L
H
Y
V
L
R
N
LIAS
1
PsiBlast_PDB
87.31
52%
-28
- C3 -
-
2B3X
2
ACOC_HUMAN
A:
[19-886]
------------------------
K
F
F
N
L
N
K
L
E
D
S
--
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
-
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
D
F
---
N
D
PSQ
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
-------------
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
---
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
--
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
-
P
T
R
D
E
I
Q
A
V
E
R
Q
-
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
-
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
--
K
T
F
Q
A
V
M
-
R
F
D
T
D
V
E
--
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
---
2
PsiBlast_PDB
87.08
52%
-29
- C3 -
-
2B3Y
3
ACOC_HUMAN
A:
[19-886]
------------------------
K
F
F
N
L
N
K
L
E
D
S
--
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
-
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
D
F
---
N
D
PSQ
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
-------------
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
---
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
--
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
-
P
T
R
D
E
I
Q
A
V
E
R
Q
-
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
-
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
--
K
T
F
Q
A
V
M
-
R
F
D
T
D
V
E
--
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
---
21
PsiBlast_CBE
86.88
52%
-27
- C3 -
-
2B3Y
2
ACOC_HUMAN
B:
[19-886]
------------------------
K
F
F
N
L
N
K
L
E
D
S
--
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
-
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
D
F
---
N
D
PSQ
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
-------------
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
---
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
--
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
-
P
T
R
D
E
I
Q
A
V
E
R
Q
-
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
-
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
--
K
T
F
Q
A
V
M
-
R
F
D
T
D
V
E
--
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
---
37
HHSearch
85.13
53%
2
- C3 -
-
2B3X
2
ACOC_HUMAN
A:
[2-887]
-------
N
P
F
A
H
L
A
E
P
L
D
P
V
Q
P
G
K
K
F
F
N
L
N
K
L
E
D
S
R
Y
--
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
-
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
----
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
D
F
NDP
S
Q
---
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
-----
G
F
K
G
F
Q
V
A
P
E
H
H
N
-----------
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
--
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
-
P
T
R
D
E
I
Q
A
V
-
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
-
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
P
E
N
-
L
K
P
Q
M
K
V
Q
V
K
L
-
D
T
G
---
K
T
F
Q
A
V
M
-
R
F
D
T
D
V
E
--
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
--
36
HHSearch
84.04
53%
3
- C3 -
-
2B3Y
2
ACOC_HUMAN
B:
[2-887]
-------
N
P
F
A
H
L
A
E
P
L
D
P
V
Q
P
G
K
K
F
F
N
L
N
K
L
E
D
S
R
Y
--
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
-
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
----
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
D
F
NDP
S
Q
---
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
-----
G
F
K
G
F
Q
V
A
P
E
H
H
N
-----------
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
--
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
-
P
T
R
D
E
I
Q
A
V
-
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
-
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
P
E
N
-
L
K
P
Q
M
K
V
Q
V
K
L
-
D
T
G
---
K
T
F
Q
A
V
M
-
R
F
D
T
D
V
E
--
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
--
3
PsiBlast_PDB
81.37
53%
-32
- C3 -
-
3SNP
-
ACOC_RABIT
A:
[34-887]
----------------------------------------
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
H
M
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
H
S
-------------------
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
R
D
Y
---
S
D
PSQ
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
-------------
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
---
D
H
K
T
F
I
Y
N
D
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
--------------
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
-
P
T
R
E
E
I
Q
A
V
E
R
Q
-
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
W
---------
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
-
I
P
E
N
L
T
P
R
--
M
H
V
Q
V
K
L
D
T
G
--
K
T
F
Q
A
V
I
-
R
F
D
T
D
V
E
--
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
---
4
PsiBlast_PDB
80.75
53%
-31
- C3 -
-
3SN2
-
ACOC_RABIT
A:
[34-887]
----------------------------------------
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
H
M
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
----------------------
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
--
D
Q
D
G
--
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
R
D
Y
---
S
D
PSQ
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
-------------
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
---
D
H
K
T
F
I
Y
N
D
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
--------------
P
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
-
N
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
-
P
T
R
E
E
I
Q
A
V
E
R
Q
-
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
--------
S
D
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
-
F
-
A
N
I
R
L
L
N
R
F
L
-
N
-----
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
-
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
-
I
P
E
N
L
T
P
R
--
M
H
V
Q
V
K
L
D
T
G
--
K
T
F
Q
A
V
I
-
R
F
D
T
D
V
E
--
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
---
38
HHSearch
56.05
29%
4
- C3 -
-
1B0K
2
ACON_PIG
A:
[33-752]
---------------------------------------
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
------
N
Q
E
I
E
-------
R
--
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
-------
L
P
--
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
------
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
--
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
Y
P
G
-------------
V
L
L
-
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
I
-
A
N
L
A
D
E
F
--
K
D
H
L
V
P
D
P
--------
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
------
K
------------------------------------
E
G
-----
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
-
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
-------
D
I
K
-
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
G
-
K
D
G
K
K
F
---
K
L
E
A
P
D
A
D
E
L
P
R
A
----
E
F
D
P
G
--
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
---------
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
P
F
D
K
W
-----
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
-----------
F
---
R
G
H
L
D
N
I
S
N
N
L
L
I
-
G
A
I
N
I
E
N
R
K
A
----------
N
S
V
R
N
A
V
T
Q
E
F
G
P
-
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
--
I
H
P
V
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
--
T
Q
E
T
I
L
L
N
H
T
F
N
E
T
Q
--
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
--
12
PsiBlast_PDB
55.70
26%
20
- C3 -
-
7ACN
2
ACON_PIG
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
P
---
G
C
---
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINIE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
9
PsiBlast_PDB
55.53
26%
20
- C3 -
-
8ACN
2
ACON_BOVIN
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
S
---
G
C
---
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINSE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
15
PsiBlast_PDB
55.47
26%
19
- C3 -
-
1C97
3
ACON_BOVIN
A:
[61-745]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
P
---
G
C
---
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINIE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
17
PsiBlast_PDB
55.45
26%
22
- C3 -
-
1B0J
2
ACON_PIG
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
P
---
G
C
---
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINIE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
7
PsiBlast_PDB
55.44
26%
19
- C3 -
-
1ACO
1
ACON_BOVIN
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
S
---
G
C
---
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINSE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
5
PsiBlast_PDB
55.26
26%
19
- C3 -
-
1AMI
2
ACON_BOVIN
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
H
--
L
V
P
D
S
---
G
C
---
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINSE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
18
PsiBlast_PDB
55.24
26%
17
- C3 -
-
1C96
2
ACON_BOVIN
A:
[61-745]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
P
---
G
C
---
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINIE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
39
HHSearch
55.06
29%
13
* C3 *
-
1C96
2
ACON_BOVIN
A:
[33-752]
---------------------------------------
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
------
N
Q
E
I
E
-------
R
--
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
---
L
P
K
V
A
V
P
S
--------
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
------
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
--
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
Y
P
G
-------------
V
L
L
-
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
I
-
A
N
L
A
D
E
F
--
K
D
H
L
V
P
D
P
--------
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
------
K
------------------------------------
E
G
-----
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
-
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
RK
D
I
K
K
G
E
K
N
T
----------
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
G
-
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
----
E
F
D
P
--
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
---------
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
L
L
E
P
F
D
K
W
-----
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
-----------
F
---
R
G
H
L
D
N
I
S
N
N
L
-
L
I
G
A
I
N
I
E
N
R
K
A
----------
N
S
V
R
N
A
V
T
Q
E
F
G
P
-
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
--
I
H
P
V
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
--
H
T
F
N
E
T
Q
--
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
--
10
PsiBlast_PDB
55.06
26%
19
- C3 -
-
5ACN
2
ACON_PIG
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
P
---
G
C
---
H
--
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINIE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
14
PsiBlast_PDB
55.01
26%
19
- C3 -
-
1NIT
1
ACON_BOVIN
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
S
---
G
C
---
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINSE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
13
PsiBlast_PDB
54.97
26%
18
- C3 -
-
1NIS
2
ACON_BOVIN
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
S
---
G
C
---
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINSE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------
8
PsiBlast_PDB
54.96
26%
19
- C3 -
-
1FGH
1
ACON_BOVIN
A:
[62-746]
----------------------------------------------------------------------------------
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
---------
V
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
--------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
--
D
H
L
V
P
D
S
---
G
C
---
H
--
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
------------------
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------
W
P
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
---------
R
K
D
I
K
K
G
E
K
N
T
I
-
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
-
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
---
P
D
A
D
E
L
P
R
A
-
E
F
-
D
P
G
Q
D
T
Y
Q
H
P
-----
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
--------
P
F
D
K
W
D
G
------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
L
K
-------------------------------
F
R
G
H
-
L
-
D
N
--
I
S
N
N
L
L
I
G
AINSE
N
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
--
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
---
T
I
L
-
L
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
---------