@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKR7: (2017-10-28 )
MSSIVAIKGFNDVLPTQTAAWRRLEQHLASLMDAYGYQQIRLPIVEQTGLFKRAIGDATDIVEKEMYTFFDKGNPPESLTLRPEGTAGCVRALVEHNLLRGATPRVWYMGPMFRYEKPQKGRYRQFHQFGVETFGVATPDIDAELIMLTARLWKRMGVDHMVQLELNTLGETDERTEYRNALVAFLNEHKDALDEDSQRRLTTNPLRILDSKIESTQKILENAPKLHDFLKEDSLSHFQQLQDYLTAAGIKFVINQKLVRGLDYYNKTVFEWTTTALGSQGTVCAGGRYDGLVGQLKGKADQSVPAVGFAMGMERLLLLLEQVEQAEIVRHCEAFLVAEPAYQSKALVLAEQLRDQLEAANSNIRIKTGSQSSMKSQMKKADQAGAVYAIILGEREWEAQQLAVKELATAEQSQVALAELVPFLIEKFTK
Atome Classification :
(22 SA)
.........10........20........30........40........50.....-...60........70.-....--...80........90........100..-.....110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-........230.......240.......250.......260.......270.......280.......290.......300.......310.......320..---...-..330.......-340..---......350.......--360------......---.---370---........380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
S
I
V
A
IKGFNDVLPT
Q
T
A
A
W
R
R
L
E
Q
H
L
A
S
L
M
D
AYGY
Q
Q
I
R
L
P
I
VEQTG
L
F
K
R
AIG-
D
A
T
D
I
V
E
K
E
M
Y
T
F
FDK-GNPP--E
S
L
T
LRPEG
T
A
G
C
V
R
A
L
V
E
H
N
L
LRGATP-
R
V
W
Y
MGPMFRYEKPQKG
R
Y
R
Q
F
H
Q
FG
V
E
T
FGVATPDI
D
A
E
L
I
M
L
T
A
R
L
W
K
RMGV
D
H
M
V
Q
L
E
LNTLGET
D
E
R
T
E
Y
R
N
A
L
V
A
F
L
N
E
H
K
DALDEDSQRRLTT
N
P
L
R
I
L
D
S
K
I
E
S
T
Q
K
I
L
E
--N
A
P
K
L
H
D
F
L
K
E
D
S
L
S
H
F
Q
Q
L
Q
D
Y
L
T
AA
G
I
K
F
V
I
N
Q
K
L
V
R
G
L
D
Y
Y
N
K
T
V
F
E
W
TTTALGSQG
T
V
CAGGRYDG
L
V
G
QLKGKADQSVP
A
V
G
F
A
M
G
M
E
R
L
L
L
L
L
E
Q
V
E
---
Q
A
E
-
I
V
R
H
C
E
A
F
LVAE-PA-YQ---
S
K
A
L
V
L
A
E
Q
L
R
D
Q
L
E
A--ANS------
N
I
R
I
KT---G---S
Q
----
S
S
M
K
S
Q
M
K
K
ADQA
G
A
V
Y
A
I
I
L
GEREW
E
A
Q
Q
L
A
V
K
E
L
A
T
A
E
Q
S
Q
V
A
L
A
E
L
V
P
F
L
I
E
K
FTK
21
PsiBlast_CBE
97.13
99%
-112
- C2 -
-
5E3I
2
SYH_ACIBS
B:
[11-437]
--
S
I
V
A
I
K
G
F
N
D
V
L
P
T
Q
T
A
A
W
R
R
L
E
Q
H
L
A
S
L
M
D
A
Y
G
Y
Q
Q
I
R
L
P
I
V
E
Q
T
G
L
F
K
R
A
I
G
-
D
A
T
D
I
V
E
K
E
M
Y
T
F
F
D
K
-
G
N
P
P
--
E
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
L
V
E
H
N
L
L
R
G
A
T
P
-
R
V
W
Y
M
G
P
M
F
R
Y
E
K
P
Q
K
G
R
Y
R
Q
F
H
Q
F
G
V
E
T
F
G
V
A
T
P
D
I
D
A
E
L
I
M
L
T
A
R
L
W
K
R
M
G
V
D
H
M
V
Q
L
E
L
N
T
L
G
E
T
D
E
R
T
E
Y
R
N
A
L
V
A
F
L
N
E
-----------------------------
K
I
L
E
--
N
A
P
K
L
H
D
F
L
K
E
D
S
L
S
H
F
Q
Q
L
Q
D
Y
L
T
A
A
G
I
K
F
V
I
N
Q
K
L
V
R
G
L
D
Y
Y
N
K
T
V
F
E
W
T
T
T
A
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
G
Q
L
K
G
K
A
D
Q
S
V
P
A
V
G
F
A
M
G
M
E
R
L
L
L
L
L
E
Q
V
E
---
Q
A
E
-
I
V
R
D
C
E
A
F
L
V
A
E
-
P
A
-
Y
Q
---
S
K
A
L
V
L
A
E
Q
L
R
D
Q
L
E
A
--
A
N
S
------
N
I
R
I
K
T
---
G
---
S
Q
----
G
S
M
K
S
Q
M
K
K
A
D
Q
A
G
A
V
Y
A
I
I
L
G
E
R
E
W
E
A
Q
Q
L
A
V
K
E
L
A
T
A
E
Q
S
Q
V
A
L
A
E
L
V
P
F
L
I
E
K
F
T
-
1
PsiBlast_PDB
95.65
99%
-112
- C2 -
-
5E3I
2
SYH_ACIBS
A:
[10-438]
-
S
S
I
V
A
I
K
G
F
N
D
V
L
P
T
Q
T
A
A
W
R
R
L
E
Q
H
L
A
S
L
M
D
A
Y
G
Y
Q
Q
I
R
L
P
I
V
E
Q
T
G
L
F
K
R
A
I
G
-
D
A
T
D
I
V
E
K
E
M
Y
T
F
F
D
K
-
G
N
P
P
--
E
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
L
V
E
H
N
L
L
R
G
A
T
P
-
R
V
W
Y
M
G
P
M
F
R
Y
E
K
P
Q
K
G
R
Y
R
Q
F
H
Q
F
G
V
E
T
F
G
V
A
T
P
D
I
D
A
E
L
I
M
L
T
A
R
L
W
K
R
M
G
V
D
H
M
V
Q
L
E
L
N
T
L
G
E
T
D
E
R
T
E
Y
R
N
A
-------------------------------------------
A
P
K
L
H
D
F
L
K
E
D
S
L
S
H
F
Q
Q
L
Q
D
Y
L
T
A
A
G
I
K
F
V
I
N
Q
K
L
V
R
G
L
D
Y
Y
N
K
T
V
F
E
W
T
T
T
A
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
G
Q
L
K
G
K
A
D
Q
S
V
P
A
V
G
F
A
M
G
M
E
R
L
L
L
L
L
E
Q
V
E
---
Q
A
E
-
I
V
R
D
C
E
A
F
L
V
A
E
-
P
A
-
Y
Q
---
S
K
A
L
V
L
A
E
Q
L
R
D
Q
L
E
A
--
A
N
S
------
N
I
R
I
K
T
---
G
---
S
Q
----
G
S
M
K
S
Q
M
K
K
A
D
Q
A
G
A
V
Y
A
I
I
L
G
E
R
E
W
E
A
Q
Q
L
A
V
K
E
L
A
T
A
E
Q
S
Q
V
A
L
A
E
L
V
P
F
L
I
E
K
F
T
K
43
HHSearch
81.82
98%
4
- C2 -
-
5E3I
2
SYH_ACIBS
B:
[11-437]
--
S
I
V
A
I
K
G
F
N
D
V
L
P
T
Q
T
A
A
W
R
R
L
E
Q
H
L
A
S
L
M
D
A
Y
G
Y
Q
Q
I
R
L
P
I
V
E
Q
T
G
L
F
K
R
A
I
G
D
A
T
D
I
-
V
E
K
E
M
Y
T
F
F
D
K
-
G
--
N
P
P
E
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
L
V
E
H
N
L
L
R
G
A
T
P
-
R
V
W
Y
M
G
P
M
F
R
Y
E
K
P
Q
K
G
R
Y
R
Q
F
H
Q
F
G
V
E
T
F
G
V
A
T
P
D
I
D
A
E
L
I
M
L
T
A
R
L
W
K
R
M
G
V
D
H
M
V
Q
L
E
L
N
T
L
G
E
T
D
E
R
T
E
Y
R
N
A
L
V
A
F
L
N
E
-----------------------------
K
I
L
E
--
N
A
P
K
L
H
D
F
L
K
E
D
S
L
S
H
F
Q
Q
L
Q
D
Y
L
T
A
A
G
I
K
F
V
I
N
Q
K
L
V
R
G
L
D
Y
Y
N
K
T
V
F
E
W
T
T
T
A
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
G
Q
L
K
G
K
A
D
Q
S
V
P
A
V
G
F
A
M
G
M
E
R
L
L
L
L
L
E
Q
V
E
---
Q
A
E
-
I
V
R
D
C
E
A
F
L
V
A
E
-
P
A
-
Y
Q
---
S
K
A
L
V
L
A
E
Q
L
R
--------
D
Q
L
E
A
A
NS
N
I
R
I
K
T
---
G
---
S
Q
----
G
S
M
K
S
Q
M
K
K
A
D
Q
A
G
A
V
Y
A
I
I
L
G
E
R
E
W
E
A
Q
Q
L
A
V
K
E
L
A
T
A
E
Q
S
Q
V
A
L
A
E
L
V
P
F
L
I
E
K
F
T
-
6
PsiBlast_PDB
77.90
48%
-77
- C2 -
-
4E51
1
SYH_BURTA
A:
[30-452]
-
E
K
L
T
G
V
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
G
I
G
-
E
V
T
D
I
V
E
K
E
M
Y
S
F
V
D
A
-
L
N
G
---
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
M
L
Y
D
G
P
K
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
---
R
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
T
G
-
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
K
L
D
D
D
A
Q
R
R
L
Y
T
N
P
L
R
V
L
D
T
K
N
P
A
L
Q
E
I
V
R
--
N
A
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
K
----
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
---
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
---
L
V
P
-
E
Q
E
G
V
D
V
Y
V
V
H
Q
G
D
A
-
A
R
---
E
Q
A
F
I
V
A
E
R
L
R
D
------
T
G
L
------
D
V
I
L
H
C
SAD
G
---
A
G
----
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
--------
S
V
Q
Q
S
V
P
--
V
E
S
L
T
E
34
PsiBlast_CBE
75.71
48%
-86
- C2 -
-
4E51
1
SYH_BURTA
B:
[29-452]
L
E
K
L
T
G
V
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
-------
D
I
V
E
K
E
M
Y
S
F
V
D
A
-
L
N
G
---
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
M
L
Y
D
G
P
K
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
-----
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
T
G
-
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
------
Q
R
R
L
Y
T
N
P
L
R
V
L
----
P
A
L
Q
E
I
V
R
--
N
A
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
-----
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
---
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
---
L
V
P
-
E
Q
E
G
V
D
V
Y
V
V
H
Q
G
D
A
-
A
R
---
E
Q
A
F
I
V
A
E
R
L
R
D
------
T
G
L
------
D
V
I
L
H
C
SAD
G
---
A
G
----
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
--------
S
V
Q
Q
S
V
P
--
V
E
S
L
T
E
3
PsiBlast_PDB
71.80
56%
-72
- C2 -
-
1KMM
1
SYH_ECOLI
A:
[4-411]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
H
-------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
26
PsiBlast_CBE
71.59
56%
-70
- C2 -
-
1KMM
1
SYH_ECOLI
C:
[4-411]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
H
------------------------------------
P
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
31
PsiBlast_CBE
71.12
56%
-75
- C2 -
-
2EL9
1
SYH_ECOLI
D:
[11-418]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
--------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
33
PsiBlast_CBE
70.97
56%
-73
- C2 -
-
2EL9
1
SYH_ECOLI
B:
[11-418]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
-----------------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
EF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
32
PsiBlast_CBE
70.92
56%
-73
- C2 -
-
2EL9
1
SYH_ECOLI
C:
[11-418]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
-----------------------------------------------
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-----
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
22
PsiBlast_CBE
70.68
56%
-83
- C2 -
-
1KMN
2
SYH_ECOLI
D:
[4-411]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
-------------------------------------------------------------
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
25
PsiBlast_CBE
70.53
56%
-78
- C2 -
-
1KMM
1
SYH_ECOLI
D:
[4-411]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
-------------------------------------------------------------
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
28
PsiBlast_CBE
70.49
56%
-77
- C2 -
-
1HTT
1
SYH_ECOLI
D:
[3-410]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
--------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
44
HHSearch
70.47
56%
-62
- C2 -
-
1KMM
1
SYH_ECOLI
C:
[4-423]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
--
G
--
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
H
------------------------------------
P
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
---
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
---
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
--------
D
E
------
L
P
G
V
K
L
---
M
T
N
H
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
--
2
PsiBlast_PDB
70.37
56%
-71
- C2 -
-
1HTT
1
SYH_ECOLI
A:
[3-410]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
-----------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
24
PsiBlast_CBE
70.24
56%
-79
- C2 -
-
1KMN
2
SYH_ECOLI
B:
[4-411]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
------------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H
--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
48
HHSearch
70.17
50%
-3
- C2 -
-
4E51
1
SYH_BURTA
A:
[31-459]
--
K
L
T
G
V
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
G
I
G
-
E
V
T
D
I
V
E
K
E
M
Y
S
F
V
D
A
L
N
--
G
--
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
M
L
Y
D
G
P
K
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
---
R
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
T
-
G
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
K
L
D
D
D
A
Q
R
R
L
Y
T
N
P
L
R
V
L
D
T
K
N
P
A
L
Q
E
I
V
R
--
N
A
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
K
----
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
---
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
---
L
V
P
-
E
Q
E
G
V
D
V
Y
V
V
H
Q
-
G
D
A
A
R
---
E
Q
A
F
I
V
A
E
R
L
R
--------
D
T
------
G
L
D
V
I
L
---
H
C--
S
A
DGAG
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
--
S
V
Q
Q
S
V
P
V
E
S
L
T
E
F
L
I
N
A
M
V
-
45
HHSearch
70.14
56%
-63
- C2 -
-
1KMN
2
SYH_ECOLI
C:
[4-423]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
--
G
--
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
H
------------------------------------
P
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
---
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
---
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
--------
D
E
------
L
P
G
V
K
L
---
M
T
N
H
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
--
4
PsiBlast_PDB
70.01
56%
-76
- C2 -
-
1KMN
2
SYH_ECOLI
A:
[4-411]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
--------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
G
S
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
29
PsiBlast_CBE
69.84
56%
-76
- C2 -
-
1HTT
1
SYH_ECOLI
C:
[3-410]
--
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
-
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
----
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
L
L
Y
N
Q
E
Q
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
-----------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
----
Q
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
---
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
PEF
K
A
D
-
P
V
--
V
D
I
Y
L
V
A
S
-
G
A
D
T
Q
---
S
A
A
M
A
L
A
E
R
L
R
D
E
L
------
P
------
G
V
K
L
M
T
---
N
H--
G
G
----
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
--------------
47
HHSearch
69.25
50%
-11
- C2 -
-
4E51
1
SYH_BURTA
B:
[31-459]
--
K
L
T
G
V
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
-------
D
I
V
E
K
E
M
Y
S
F
V
D
A
L
N
--
G
--
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
M
L
Y
D
G
P
K
-
R
L
W
Y
I
G
P
M
F
R
H
E
R
-----
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
T
-
G
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
------
Q
R
R
L
Y
T
N
P
L
R
V
L
----
P
A
L
Q
E
I
V
R
--
N
A
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
-----
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
---
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
---
L
V
P
-
E
Q
E
G
V
D
V
Y
V
V
H
Q
-
G
D
A
A
R
---
E
Q
A
F
I
V
A
E
R
L
R
--------
D
T
------
G
L
D
V
I
L
---
H
C--
S
A
DGAG
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
--
S
V
Q
Q
S
V
P
V
E
S
L
T
E
F
L
I
N
A
M
V
-
8
PsiBlast_PDB
55.90
37%
12
- C2 -
-
4RDX
2
SYH_THET2
A:
[7-420]
-----
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
------------
E
M
F
T
F
Q
D
R
-
G
G
----
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
M
K
V
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
R
R
L
-
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
L
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
G
A
Q
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
---
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
-
A
E
---
G
F
G
-
L
P
E
E
K
G
P
D
L
Y
L
I
-
P
L
-
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
L
R
A
E
Y
A
L
A
------
P
R
K
P
A
K
---
G
---
L
E
----
E
A
L
K
R
--------
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
----