@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMX3: (2017-11-11 )
MNFQRMTDLNLAGKRVLIREDLNVPVKNGVITSDARLRAALPTIKAALEKGAAVMVFSHLGRPVEGEPKPEQSLAPVAAYLTEALGQEVKLFTDYLDGVEVEAGQVVLLENVRFNPGEKKNNPELAQKYAALCDVFVMDAFGTAHRAEASTEGVARFAPVAAAGPLLAAELDALGRAMQTPEKPMVAIVAGSKVSTKLDVLNSLSGICDQLIVGGGIANTFLAAAGYNVGKSLYEADLVETAKQIAAKVSVPLPTDVVVADASQINFEDFLGSLAAAQAVIKKVEDVTANDMILDVGPETAKAFANILTTSKTILWNGPVGVFEVDQFGEGTKALSLAVAQSDAFSIAGGGDTLAAIDKYNVADQIGYISTGGGAFLEFVEGKTLPAVAVLLERA
Atome Classification :
(65 SA)
.......--..10........20......-..30.........40........50.-.-....-..60..-------------.-....---------------.70.--.......80-----------........90...-..------..------.------100---.-------.-------......110...---------------..----.----.-----------120--.---------------.-------.-------......----130-------------...-.....140.......150.....--..160.........170.......180.......190.......200..--..--...210.......220..-.-.-.-..230...-------.-------...240.....-----.-----.250.........260.......270-..-.-.....280-..-.....290.......300.......310.......320.......330----.-......340-.----.--..---..---...350.......360.......370.......380.......390...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNFQRMT--DLNLAG
K
R
V
L
I
REDLNVPVK-N
G
V
-ITS
D
A
R
L
R
A
A
L
P
T
I
K
A
A
L
EKG
A
-
A
-
V
M
V
F
-
S
HLGRP-------------V-EGEP---------------KPEQ--SL
A
P
V
A
A
Y
L
-----------
T
E
A
L
G
Q
E
V
K
L
F
T
D
-
Y
L------D
G
------
V
------EV----E-------A-------G
Q
V
V
L
L
ENVRFN---------------PG----E----K-----------K----N---------------
N
-------
P
-------
E
L
A
Q
K
Y
----
A
A
--------------
L
C
D
-
V
F
V
M
DAFGTAHRAEASTEGVARF--APV--AAAG
P
L
L
A
A
E
L
D
A
L
G
R
A
MQTPEK
P
M
V
A
I
V
AGSK
V
S
T
K
L
D
V
L
N
S
L
--
S
G
--
I
C
D
Q
L
IVGG
G
I
A
N
T
F
L
A
A-A-G-Y-
N
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
E
T
A
K
Q
I
A
A
-----K-----VS--VPLPT
D
V
V
V
ADASQI
N
F
E
D
F
L
--
G
S
-
L
-
A
A
A
Q
A
V
I
K
-
K
V
-
E
DVTAN
D
M
I
L
DVGP
E
T
A
K
A
F
A
N
I
LTTS
K
T
I
L
WNGPV
G
V
F
E
V
D
QFGEG
T
----
K
-
A
L
S
L
A
V
A---Q----S--D
A
---
F
S
---IAGGGD
T
L
A
A
IDKYNVADQI
G
Y
I
STG
G
G
A
F
L
E
FVEGKT
L
P
A
V
A
V
L
LERA
76
HHSearch
88.60
66%
-123
- C9 -
-
1ZMR
-
PGK_ECOLI
A:
[2-385]
-
S
V
I
K
M
T
--
D
L
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
K
-
D
G
K
-
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
-
K
-
V
M
V
T
-
S
H
L
G
R
P
-------------
T
-
E
G
E
Y
---------------
N
E
E
F
--
S
L
L
P
V
V
N
Y
L
-----------
K
D
K
L
S
N
P
V
R
L
V
K
D
-
Y
L
------
D
G
------
V
------
D
V
----
A
-------
E
-------
G
E
L
V
V
L
E
N
V
R
F
N
---------------
K
G
----
E
----
K
-----------
K
----
D
---------------
D
-------
E
-------
T
L
S
K
K
Y
----
A
A
--------------
L
C
D
-
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
G
K
F
--
A
D
V
--
A
C
A
G
P
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
--
S
K
--
I
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
-
H
-
D
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
D
E
A
K
R
L
L
T
-----
T
-----
C
N
--
I
P
V
P
S
D
V
R
V
A
T
E
----
F
S
----------
E
T
A
P
A
T
L
K
-
S
V
-
N
D
V
K
A
D
E
Q
I
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
----
E
-
I
V
A
N
A
I
A
---
D
----
S
--
E
A
---
F
S
---
I
A
G
G
G
D
T
L
A
A
I
D
L
F
G
I
A
D
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
R
A
2
PsiBlast_PDB
88.18
64%
-123
- C9 -
-
1ZMR
-
PGK_ECOLI
A:
[2-385]
-
S
V
I
K
M
T
--
D
L
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
K
-
D
G
K
-
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
-
K
-
V
M
V
T
-
S
H
L
G
R
P
-------------
T
-
E
G
E
Y
---------------
N
E
E
F
--
S
L
L
P
V
V
N
Y
L
-----------
K
D
K
L
S
N
P
V
R
L
V
K
D
-
Y
L
------
D
G
------
V
------
D
V
----
A
-------
E
-------
G
E
L
V
V
L
E
N
V
R
F
N
---------------
K
G
----
E
----
K
-----------
K
----
D
---------------
D
-------
E
-------
T
L
S
K
K
Y
----
A
A
--------------
L
C
D
-
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
G
K
F
--
A
D
V
--
A
C
A
G
P
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
--
S
K
--
I
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
-
H
-
D
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
D
E
A
K
R
L
L
T
-----
T
-----
C
N
--
I
P
V
P
S
D
V
R
V
A
----
T
E
F
S
E
----------
T
A
P
A
T
L
K
-
S
V
-
N
D
V
K
A
D
E
Q
I
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
----
E
-
I
V
A
N
A
I
A
---
D
----
S
--
E
A
---
F
S
---
I
A
G
G
G
D
T
L
A
A
I
D
L
F
G
I
A
D
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
R
A
22
PsiBlast_CBE
81.13
57%
-79
- C9 -
-
4NG4
1
PGK_COXBU
B:
[14-401]
--
F
L
S
M
S
--
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
-
N
G
K
-
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
-
S
H
L
G
R
P
-------------
E
-
E
G
K
F
---------------
E
K
E
F
--
S
L
A
P
V
A
R
L
L
-----------
S
K
K
L
N
-
K
V
P
L
I
N
D
-
W
L
------
K
G
------
V
------
A
V
----
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
G
----
E
----
N
-----------
E
----
N
---------------
N
-------
T
-------
E
L
A
K
R
M
----
A
E
--------------
L
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
-----
K
A
A
E
K
N
V
S
--
L
P
L
P
V
D
V
I
V
A
D
E
L
S
---
E
D
-----------
A
K
A
T
V
K
-
N
I
-
D
A
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
----
R
-
A
L
A
Q
A
V
A
---
K
----
S
--
T
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
A
84
HHSearch
80.70
59%
-79
- C9 -
-
4NG4
1
PGK_COXBU
B:
[16-401]
----
S
M
S
--
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
-
N
G
K
-
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
-
S
H
L
G
R
P
-------------
E
-
E
G
K
F
---------------
E
K
E
F
--
S
L
A
P
V
A
R
L
L
-----------
S
K
K
L
N
-
K
V
P
L
I
N
D
-
W
L
------
K
G
------
V
------
A
V
----
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
G
----
E
----
N
-----------
E
----
N
---------------
N
-------
T
-------
E
L
A
K
R
M
----
A
E
--------------
L
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
-----
K
A
A
E
K
N
V
S
--
L
P
L
P
V
D
V
I
V
A
D
E
----
L
S
----------
E
D
A
K
A
T
V
K
-
N
I
-
D
A
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
----
R
-
A
L
A
Q
A
V
A
---
K
----
S
--
T
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
A
71
HHSearch
80.41
60%
-72
- C9 -
-
4EHJ
-
PGK_FRATT
B:
[2-390]
-
S
F
L
T
L
K
--
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
-
D
G
K
-
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
-
S
H
L
G
R
P
-------------
T
-
E
G
E
Y
---------------
D
S
Q
F
--
S
L
E
P
V
A
K
A
L
-----------
S
E
I
I
N
K
P
V
K
F
A
K
D
-
W
L
------
D
G
------
V
------
D
V
----
K
-------
A
-------
G
E
I
V
M
C
E
N
V
R
F
N
---------------
S
G
----
E
----
K
-----------
K
----
S
---------------
T
-------
D
-------
D
L
S
K
K
I
----
A
S
--------------
L
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
-------
Q
-------
D
L
V
A
E
A
T
E
I
L
A
-----
K
AKALG
V
N
--
I
P
V
P
V
D
V
R
V
A
K
E
----
F
S
----------
E
N
A
Q
A
I
I
K
-
K
V
-
S
D
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
----
K
-
A
L
S
L
A
I
A
---
Q
----
S
--
H
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
70
HHSearch
80.07
60%
-72
- C9 -
-
4FEY
1
PGK_FRATT
A:
[4-393]
M
S
F
L
T
L
K
--
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
-
D
G
K
-
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
-
S
H
L
G
R
P
-------------
T
-
E
G
E
Y
---------------
D
S
Q
F
--
S
L
E
P
V
A
K
A
L
-----------
S
E
I
I
N
K
P
V
K
F
A
K
D
-
W
L
------
D
G
------
V
------
D
V
----
K
-------
A
-------
G
E
I
V
M
C
E
N
V
R
F
N
---------------
S
G
----
E
----
K
-----------
K
----
S
---------------
T
-------
D
-------
D
L
S
K
K
I
----
A
S
--------------
L
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
-------
Q
-------
D
L
V
A
E
A
T
E
I
L
A
-----
K
A
K
A
L
G
V
N
--
I
P
V
P
V
D
V
R
V
A
K
E
----
F
S
----------
E
N
A
Q
A
I
I
K
-
K
V
-
S
D
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
----
K
-
A
L
S
L
A
I
A
---
Q
----
S
--
H
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
21
PsiBlast_CBE
80.05
57%
-78
- C9 -
-
4NG4
1
PGK_COXBU
C:
[14-401]
--
F
L
S
M
S
--
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
-
N
G
K
-
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
-
S
H
L
G
R
P
-------------
E
-
E
G
K
F
---------------
E
K
E
F
--
S
L
A
P
V
A
R
L
L
-----------
S
K
K
L
N
--
V
P
L
I
N
D
-
W
L
------
K
G
------
V
------
A
V
----
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
G
----
E
----
N
-----------
E
----
N
---------------
N
-------
T
-------
E
L
A
K
R
M
----
A
E
--------------
L
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
-----
K
A
A
E
K
N
V
S
--
L
P
L
P
V
D
V
I
V
A
D
E
L
S
---
E
D
-----------
A
K
A
T
V
K
-
N
I
-
D
A
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
----
R
-
A
L
A
Q
A
V
A
---
K
----
S
--
T
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
A
4
PsiBlast_PDB
79.59
58%
-71
- C9 -
-
4FEY
1
PGK_FRATT
A:
[4-393]
M
S
F
L
T
L
K
--
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
-
D
G
K
-
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
-
S
H
L
G
R
P
-------------
T
-
E
G
E
Y
---------------
D
S
Q
F
--
S
L
E
P
V
A
K
A
L
-----------
S
E
I
I
N
K
P
V
K
F
A
K
D
-
W
L
------
D
G
------
V
------
D
V
----
K
-------
A
-------
G
E
I
V
M
C
E
N
V
R
F
N
---------------
S
G
----
E
----
K
-----------
K
----
S
---------------
T
-------
D
-------
D
L
S
K
K
I
----
A
S
--------------
L
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
-------
Q
-------
D
L
V
A
E
A
T
E
I
L
A
-----
K
A
K
A
L
G
V
N
--
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
--------------
A
Q
A
I
I
K
-
K
V
-
S
D
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
----
K
-
A
L
S
L
A
I
A
---
Q
----
S
--
H
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
5
PsiBlast_PDB
79.45
57%
-71
- C9 -
-
4EHJ
-
PGK_FRATT
A:
[2-390]
-
S
F
L
T
L
K
--
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
-
D
G
K
-
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
-
S
H
L
G
R
P
-------------
T
-
E
G
E
Y
---------------
D
S
Q
F
--
S
L
E
P
V
A
K
A
L
-----------
S
E
I
I
N
K
P
V
K
F
A
K
D
-
W
L
------
D
G
------
V
------
D
V
----
K
-------
A
-------
G
E
I
V
M
C
E
N
V
R
F
N
---------------
S
G
----
E
----
K
-----------
K
----
S
---------------
T
-------
D
-------
D
L
S
K
K
I
----
A
S
--------------
L
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
-------
Q
-------
D
L
V
A
E
A
T
E
I
L
A
-----
K
A
K
A
L
G
V
N
--
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
--------------
A
Q
A
I
I
K
-
K
V
-
S
D
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
----
K
-
A
L
S
L
A
I
A
---
Q
----
S
--
H
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
3
PsiBlast_PDB
79.16
57%
-71
- C9 -
-
4NG4
1
PGK_COXBU
A:
[14-401]
--
F
L
S
M
S
--
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
-
N
G
K
-
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
-
S
H
L
G
R
P
-------------
E
-
E
G
K
F
---------------
E
K
E
F
--
S
L
A
P
V
A
R
L
L
-----------
S
K
K
-----
P
L
I
N
D
-
W
L
------
K
G
------
V
------
A
V
----
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
G
----
E
----
N
-----------
E
----
N
---------------
N
-------
T
-------
E
L
A
K
R
M
----
A
E
--------------
L
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
-----
K
A
A
E
K
N
V
S
--
L
P
L
P
V
D
V
I
V
A
D
E
L
S
---
E
D
-----------
A
K
A
T
V
K
-
N
I
-
D
A
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
----
R
-
A
L
A
Q
A
V
A
---
K
----
S
--
T
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
A
85
HHSearch
78.65
59%
-71
- C9 -
-
4NG4
1
PGK_COXBU
A:
[16-401]
----
S
M
S
--
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
-
N
G
K
-
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
-
S
H
L
G
R
P
-------------
E
-
E
G
K
F
---------------
E
K
E
F
--
S
L
A
P
V
A
R
L
L
-----------
S
K
K
-----
P
L
I
N
D
-
W
L
------
K
G
------
V
------
A
V
----
E
-------
P
-------
G
Q
A
I
L
C
E
N
V
R
F
N
---------------
K
G
----
E
----
N
-----------
E
----
N
---------------
N
-------
T
-------
E
L
A
K
R
M
----
A
E
--------------
L
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
-------
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
-----
K
A
A
E
K
N
V
S
--
L
P
L
P
V
D
V
I
V
A
D
E
----
L
S
----------
E
D
A
K
A
T
V
K
-
N
I
-
D
A
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
----
R
-
A
L
A
Q
A
V
A
---
K
----
S
--
T
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
A
80
HHSearch
66.06
48%
3
- C9 -
-
1VPE
2
PGKT_THEMA
A:
[3-396]
---
M
T
I
R
--
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
-
D
G
V
-
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
-
S
H
L
G
R
P
-------------
K
-
G
E
P
----------------
S
P
E
F
--
S
L
A
P
V
A
K
R
L
-----------
S
E
L
L
G
K
E
V
K
F
V
P
A
-
V
V
------
G
D
E
V
K
K
A
V
E
------
E
L
----
K
-------
E
-------
G
E
V
L
L
L
E
N
T
R
F
H
---------------
P
G
----
E
----
T
-----------
K
----
N
---------------
D
-------
P
-------
E
L
A
K
F
W
----
A
S
--------------
L
A
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
--
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
--
M
E
--
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
-
K
-
E
V
G
S
S
R
V
E
-------
E
-------
D
K
I
D
L
A
K
E
L
V
E
-----
K
A
K
E
K
G
V
E
--
I
V
L
P
V
D
A
V
I
A
Q
K
----
I
E
----------
P
G
V
E
K
K
V
V
-
R
I
D
D
G
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
----
K
-
Q
V
A
L
A
I
A
---
A
L
T
E
-
K
--
G
A
---
I
T
---
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
-
78
HHSearch
65.38
96%
-
- C9 -
-
5BT8
-
?
F:
[1-395]
M
N
F
Q
R
M
T
--
D
L
N
L
A
G
K
R
V
L
I
R
E
D
L
N
V
P
V
K
-
N
G
V
-
I
T
S
D
A
R
L
R
A
A
L
P
T
I
K
A
A
L
E
K
G
A
-
A
-
V
M
V
F
-
S
H
L
G
R
P
-------------
V
E
G
E
P
----------------
K
P
E
Q
--
S
L
A
P
V
A
A
Y
L
-----------
T
E
A
L
G
Q
E
V
K
L
F
T
D
Y
L
D
------
G
-------
V
------
E
V
----
E
-------
A
-------
G
Q
V
V
L
L
E
N
V
R
F
N
---------------
P
G
----
E
----
K
-----------
K
----
N
---------------
N
-------
P
-------
E
L
A
Q
K
Y
----
A
A
--------------
L
C
D
-
V
F
V
M
D
A
F
G
T
A
H
R
A
E
A
S
T
E
G
V
A
R
F
--
A
P
V
--
A
A
A
G
P
L
L
A
A
E
L
D
A
L
G
R
A
M
Q
T
P
E
K
P
M
V
A
I
V
A
G
S
K
V
S
T
K
L
D
V
L
N
S
L
--
S
G
--
I
C
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
A
A
-
A
-
G
-
Y
-
N
V
G
K
S
L
Y
E
-------
A
-------
D
L
V
E
T
A
K
Q
I
A
A
-----
K
-----
V
S
--
V
P
L
P
T
D
V
V
V
A
D
A
----
S
Q
I
N
F
ED
F
L
G
S
L
A
A
A
Q
A
V
I
K
-
K
V
-
E
D
V
T
A
N
D
M
I
L
D
V
G
P
E
T
A
K
A
F
A
N
I
L
T
T
S
K
T
I
L
W
N
G
P
V
G
V
F
E
V
D
Q
F
G
E
G
T
----
K
-
A
L
S
L
A
V
A
---
Q
----
S
--
D
A
---
F
S
---
I
A
G
G
G
D
T
L
A
A
I
D
K
Y
N
V
A
D
Q
I
G
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
T
L
P
A
V
A
V
L
L
E
R
A
72
HHSearch
65.14
48%
-5
- C9 -
-
1PHP
1
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
--
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
-
Q
G
A
-
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
-
S
H
L
G
R
P
-------------
K
-
G
K
V
----------------
V
E
E
L
--
R
L
D
A
V
A
K
R
L
-----------
G
E
L
L
E
R
P
V
A
K
T
N
E
-
A
V
------
G
D
E
V
K
A
A
V
D
------
R
L
----
N
-------
E
-------
G
D
V
L
L
L
E
N
V
R
F
Y
---------------
P
G
----
E
----
E
-----------
K
----
N
---------------
D
-------
P
-------
E
L
A
K
A
F
----
A
E
--------------
L
A
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
--
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
--
L
E
--
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
-
H
-
D
V
G
K
S
L
L
E
-------
E
-------
D
K
I
E
L
A
K
S
F
M
E
-----
K
A
K
E
K
G
V
R
--
F
Y
M
P
V
D
V
V
V
A
D
R
----
F
A
----------
N
D
A
N
T
K
V
V
-
P
I
-
D
A
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
----
K
-
A
I
A
E
A
L
A
---
E
A---
L
--
D
T
---
Y
S
---
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
-
74
HHSearch
64.90
42%
1
* C9 *
-
3Q3V
2
PGK_CAMJE
A:
[7-399]
--
I
I
S
I
K
--
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
-
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
-
S
H
L
G
R
P
-------------
K
-
E
I
-----------------
S
S
K
Y
--
S
L
E
P
V
A
K
R
L
-----------
A
R
L
L
D
K
E
I
V
M
A
K
D
-
V
I
------
G
E
D
A
K
T
K
A
M
------
N
L
----
K
-------
A
-------
G
E
I
L
L
L
E
N
L
R
F
E
---------------
K
G
----
E
----
T
-----------
K
----
N
---------------
D
-------
E
-------
N
L
A
K
E
L
----
A
S
--------------
M
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
--
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
-------
E
-------
E
L
L
E
E
A
N
K
I
L
T
-----
K
G
K
N
L
G
V
K
--
I
Y
L
P
V
D
V
V
A
A
P
A
----
C
---------
S
-
Q
D
V
P
M
K
F
V
-
P
A
-
Q
E
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
----
I
-
K
M
S
H
Y
I
S
---
E
----
G
--
H
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--
12
PsiBlast_PDB
64.83
40%
1
- C9 -
-
3Q3V
2
PGK_CAMJE
A:
[10-399]
-----
I
K
--
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
-
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
-
S
H
L
G
R
P
-------------
K
-
E
I
S
S
---------------
K
--
Y
--
S
L
E
P
V
A
K
R
L
-----------
A
R
L
L
D
K
E
I
V
M
A
K
D
-
V
I
G
E
D
A
K
T
K
A
------
M
------
N
L
----
K
-------
A
-------
G
E
I
L
L
L
E
N
L
R
F
E
---------------
K
G
----
E
----
T
-----------
K
----
N
---------------
D
-------
E
-------
N
L
A
K
E
L
----
A
S
--------------
M
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
K
H
--
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
-------
E
-------
E
L
L
E
E
A
N
K
I
L
T
-----
K
G
K
N
L
G
V
K
--
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
---
Q
D
V
P
--
M
K
-
F
-
V
P
A
Q
---------
E
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
----
I
-
K
M
S
H
Y
I
S
---
E
----
G
--
H
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--
7
PsiBlast_PDB
64.60
44%
-14
- C9 -
-
1PHP
1
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
--
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
-
Q
G
A
-
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
-
S
H
L
G
R
P
---------------
K
G
K
V
---------------
V
E
E
L
--
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
G
D
E
V
K
A
A
V
D
-
R
L
------
N
----------------------------
E
-------
G
D
V
L
L
L
E
N
V
R
F
Y
---------------
P
G
----
E
----
E
-----------
K
----
N
---------------
D
-------
P
-------
E
L
A
K
A
F
----
A
E
--------------
L
A
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
--
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
--
L
E
--
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
-
H
-
D
V
G
K
S
L
L
E
-------
E
-------
D
K
I
E
L
A
K
S
F
M
E
-----
K
A
K
E
K
G
V
R
--
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
--------------
A
N
T
K
V
V
-
P
I
-
D
A
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
----
K
A
I
A
E
A
L
A
E
---
A
----
L
--
D
T
---
Y
S
---
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
-
73
HHSearch
64.33
42%
0
- C9 -
-
3Q3V
4
PGK_CAMJE
B:
[7-399]
--
I
I
S
I
K
--
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
-
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
-
S
H
L
G
R
P
-------------
K
-
E
I
-----------------
S
S
K
Y
--
S
L
E
P
V
A
K
R
L
-----------
A
R
L
L
D
K
E
I
V
M
A
K
D
-
V
I
------
G
E
D
A
K
T
K
A
M
------
N
L
----
K
-------
A
-------
G
E
I
L
L
L
E
N
L
R
F
E
---------------
K
G
----
E
----
T
-----------
K
----
N
---------------
D
-------
E
-------
N
L
A
K
E
L
----
A
S
--------------
M
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
--
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
-------
E
-------
E
L
L
E
E
A
N
K
I
L
T
-----
K
G
K
N
L
G
V
K
--
I
Y
L
P
V
D
V
V
A
A
P
A
----
C
---------
S
-
Q
D
V
P
M
K
F
V
-
P
A
-
Q
E
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
----
I
-
K
M
S
H
Y
I
S
---
E
----
G
--
H
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
-
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--
87
HHSearch
63.99
43%
-12
- C9 -
-
1QPG
2
PGK_YEAST
A:
[7-415]
----
S
V
Q
--
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
-
S
H
L
G
Q
P
-------------
N
-
G
E
R
----------------
N
E
K
Y
--
S
L
A
P
V
A
K
E
L
-----------
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
------
G
P
E
V
E
A
A
V
K
------
A
S
----
A
-------
P
-------
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
E
----
E
----
E
-----------
G
S
R
K
V
D
GQKVKAS
K
E
D
-----
V
-------
Q
-------
K
F
R
H
E
L
----
S
S
--------------
L
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
-
E
-
N
T
E
I
G
D
S
I
F
D
-------
K
-------
A
G
A
E
I
V
P
K
L
M
E
-----
K
A
K
A
K
G
V
E
--
V
V
L
P
V
D
F
I
I
A
D
A
----
F
S
----------
A
D
A
N
T
K
T
V
-
T
D
K
E
G
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
----
K
-
A
L
L
D
E
V
V
---
K
S
---
S
A
A
G
N
---
T
V
---
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
47
PsiBlast_CBE
63.89
38%
-27
- C9 -
-
13PK
2
PGKC_TRYBB
A:
[3-412]
---
K
S
I
N
--
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
-
N
G
K
-
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
-
S
H
L
G
R
P
K
G
I
P
M
A
Q
A
G
K
I
R
S
T
-
G
G
V
P
---------------
G
F
Q
Q
KA
T
L
K
P
V
A
K
R
L
-----------
S
E
L
L
L
R
P
V
T
F
A
P
D
-
C
L
------
N
A
------
A
------
D
V
V
S
K
M
S
-------
P
-------
G
D
V
V
L
L
E
N
V
R
F
Y
---------------
K
E
----
E
GSKK
A
-----------
K
----
D
---------------
R
-------
E
-------
A
M
A
K
I
L
----
A
S
--------------
Y
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
--
L
G
N
--
G
A
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
--
L
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
-------
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
A
E
D
R
K
-----
V
Q
--
V
I
L
P
I
D
H
V
C
----
H
T
E
F
K
----------
A
V
D
S
P
L
I
T
-
E
D
-
Q
N
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
-
A
M
G
R
G
T
H
---
E
----
H
--
G
L
---
M
S
---
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
----
43
PsiBlast_CBE
63.81
38%
-29
- C9 -
-
16PK
2
PGKC_TRYBB
A:
[3-412]
---
K
S
I
N
--
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
-
N
G
K
-
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
-
S
H
L
G
R
P
K
G
I
P
MAQ
A
G
K
I
R
S
T
-
G
G
V
P
---------------
G
F
Q
Q
KA
T
L
K
P
V
A
K
R
L
-----------
S
E
L
L
L
R
P
V
T
F
A
P
D
-
C
L
------
N
A
------
A
------
D
V
V
S
K
M
S
-------
P
-------
G
D
V
V
L
L
E
N
V
R
F
Y
---------------
K
E
----
E
GSKK
A
-----------
K
----
D
---------------
R
-------
E
-------
A
M
A
K
I
L
----
A
S
--------------
Y
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
--
L
G
N
--
G
A
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
--
L
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
-------
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
A
E
D
R
K
-----
V
Q
--
V
I
L
P
I
D
H
V
C
----
H
T
E
F
K
----------
A
V
D
S
P
L
I
T
-
E
D
-
Q
N
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
-
A
M
G
R
G
T
H
---
E
----
H
--
G
L
---
M
S
---
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
----
54
PsiBlast_CBE
63.74
38%
-6
- C9 -
-
1HDI
2
PGK1_PIG
A:
[1-410]
-
N
K
L
T
L
D
--
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
-
A
A
Q
-
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
S
P
---------------
M
P
D
K
Y-
S
L
Q
P
V
A
A
E
L
-----------
K
S
A
L
G
K
A
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
A
V
----
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
VEEEG
K
G
K
D
ASG
N
K
A
A
G
----
E
----
P
-----------
A
----
K
---------------
I
-------
K
-------
A
F
R
A
S
L
----
S
A
--------------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
A
G
K
K
I
V
K
N
L
M
S
-----
K
A
A
A
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
-------
K
F
D
--
E
Q
-
A
-
K
I
G
Q
A
T
V
---
A
-
S
G
I
P
A
G
W
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
38
PsiBlast_CBE
63.62
39%
1
- C9 -
-
1VJD
1
PGK1_PIG
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
I
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
S
K
V
K
----
A
---------------
D
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
S
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
35
PsiBlast_CBE
63.57
39%
-1
- C9 -
-
2XE8
2
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
82
HHSearch
63.47
41%
-26
- C9 -
-
16PK
2
PGKC_TRYBB
A:
[3-415]
---
K
S
I
N
--
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
-
N
G
K
-
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
-
E
G
G
S
-
C
V
L
M
-
S
H
L
G
R
P
-------------
K
-
G
I
P
M
AQ
A
G
K
I
R
S
T
GGVPGF
Q
Q
K
A
--
T
L
K
P
V
A
K
R
L
-----------
S
E
L
L
L
R
P
V
T
F
A
P
D
-
C
L
------
N
A
A
D
V
V
--
S
------
K
M
----
S
-------
P
-------
G
D
V
V
L
L
E
N
V
R
F
Y
---------------
K
E
----
E
----
G
S----------
K
----
K
A
K
D
------------
R
-------
E
-------
A
M
A
K
I
L
----
A
S
--------------
Y
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
--
L
G
N
--
G
A
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
--
L
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
-------
E
-------
S
K
L
E
F
A
R
S
L
L
K
-----
K
A
E
D
R
K
V
Q
--
V
I
L
P
I
D
H
V
C
H
T
E
----
F
K
----------
A
V
D
S
P
L
I
T
-
E
D
-
Q
N
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
----
F
-
A
I
A
K
A
M
G
---
R
G
T
H
E
H
--
G
L
---
M
S
---
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
-
37
PsiBlast_CBE
63.37
39%
-1
- C9 -
-
2XE6
1
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
40
PsiBlast_CBE
63.20
39%
0
- C9 -
-
4O33
2
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
36
PsiBlast_CBE
63.16
39%
-1
- C9 -
-
2XE7
2
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
10
PsiBlast_PDB
63.12
43%
-2
- C9 -
-
3ZLB
5
PGK_STRP2
A:
[6-398]
-----
V
K
--
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
-
D
G
V
-
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
L
F
-
S
H
L
G
R
V
-------------
K
-
E
E
S
D
---------------
K
A
G
K
--
S
L
A
P
V
A
A
D
L
-----------
A
A
K
L
G
Q
D
V
-
V
F
P
G
-
V
T
------
R
G
------
A
------
E
L
----
E
-------
A
A
I
N
A
LED
G
Q
V
L
L
V
E
N
T
R
Y
E
DVDG-----------
K
K
----
E
----
S
-----------
K
----
N
---------------
D
-------
P
-------
E
L
G
K
Y
W
----
A
S
--------------
L
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
--
V
E
K
--
A
V
A
G
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
--
L
E
--
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
-
Q
-
G
-
I
-
E
I
G
N
S
L
V
E
-------
E
-------
D
K
L
D
V
A
K
A
L
L
E
-----
K
-----
A
N
GK
L
I
L
P
V
D
S
K
E
A
N
A
-------
F
A
--
G
Y
-
T
-
E
V
R
D
T
----
E
G
-
E
A
V
S
E
G
F
L
G
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
---
G
-
V
M
D
A
I
V
K
---
Q
----
P
--
G
V
---
K
S
---
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
-
39
PsiBlast_CBE
62.95
39%
2
- C9 -
-
1VJC
1
PGK1_PIG
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
I
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
S
K
V
K
----
A
---------------
D
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
S
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
48
PsiBlast_CBE
62.73
39%
-8
- C9 -
-
4O3F
2
PGK1_MOUSE
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
A
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
N
A
C
ANPA
A
-------
G
T
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
D
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
Y
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
S
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
18
PsiBlast_PDB
62.57
39%
0
- C9 -
-
3C3C
2
PGK1_HUMAN
A:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
13
PsiBlast_PDB
62.51
39%
-2
- C9 -
-
1KF0
2
PGK1_PIG
A:
[8-413]
-----
L
D
--
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
S
P
---------------
M
P
D
K
Y-
S
L
Q
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ADPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
K
T
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
N
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
-------
F
D
--
E
H
-
A
-
K
T
G
Q
A
T
V
---
A
-
S
G
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
6
PsiBlast_PDB
62.44
46%
32
- C9 -
-
1VPE
2
PGKT_THEMA
A:
[1-393]
---
E
K
M
T
IR
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
-
D
G
V
-
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
-
S
H
L
G
R
P
---------------
K
G
E
P
---------------
S
P
E
F
--
S
L
A
P
V
A
K
R
L
-----------
S
E
L
L
G
K
E
V
K
-
F
V
P
-
A
V
------
V
G
------
D
------
E
V
----
K
-------
K
A
V
E
E
LKE
G
E
V
L
L
L
E
N
T
R
F
H
---------------
P
G
----
E
----
T
-----------
K
----
N
---------------
D
-------
P
-------
E
L
A
K
F
W
----
A
S
--------------
L
A
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
--
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
--
M
E
--
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
-
K
-
E
V
G
S
S
R
V
E
-------
E
-------
D
K
I
D
L
A
K
E
L
V
E
-----
K
A
K
E
K
G
V
E
--
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
-------------
K
K
V
V
R
-
I
D
-
D
G
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
----
K
-
Q
V
A
L
A
I
A
A
L
T
E
----
K
--
G
A
---
I
T
---
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
----
34
PsiBlast_CBE
62.28
39%
-2
- C9 -
-
2YBE
2
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKGKK
V
-----
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
83
HHSearch
61.99
41%
-3
- C9 -
-
1VJC
1
PGK1_PIG
A:
[7-415]
----
T
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
-
S
H
L
G
R
P
-------------
D
-
G
I
P
M
---------------
P
D
K
Y
--
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
------
G
P
E
V
E
K
A
C
A
------
D
P
----
A
-------
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
-----------
G
----
K
G
K
D
ASG
S
K
V
K
A
D
P
A
K
I
-------
E
-------
A
F
R
A
S
L
----
S
K
--------------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
-
N
N
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
S
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
----
F
D
----------
E
N
A
K
T
G
Q
A
-
T
V
A
S
G
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
----
K
-
A
L
M
D
E
V
V
---
K
A
---
T
S
R
G
C
---
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--
58
PsiBlast_CBE
61.94
34%
-18
- C9 -
-
2CUN
4
PGK_PYRHO
A:
[3-398]
----
R
L
E
--
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
-
D
G
K
-
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
-
T
H
Q
G
K
P
-------------
Y
-
S
E
D
Y
---------------
T
T
T
E
--
E
H
A
R
V
---
L
-----------
S
E
L
L
D
Q
H
V
E
Y
I
E
D
-
I
F
------
G
R
------
Y
A
R
E
K
I
K
E
L
----
K
-------
S
-------
G
E
V
A
I
L
E
N
L
R
F
S
---------------
A
E
----
E
----
V
-----------
K
----
N
---------------
K
-------
P
I
E
E
C
E
K
T
F
L
V
K
K
L
----
S
K
--------------
V
I
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
M
--
I
M
-
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
--
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
F
M
K
K
K
GL
L
-------
D
Y
V
K
H
A
E
E
I
L
D
-----
E
-----
F
Y
PY
I
R
T
P
V
D
F
A
V
---------
D
Y
K
--
G
E
-
R
-
V
E
I
D
-
L
L
S
-
E
N
-
R
G
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
----
V
-
E
V
F
K
A
I
A
---
D
----
S
--
P
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
----
16
PsiBlast_PDB
61.92
39%
-4
- C9 -
-
3C3A
1
PGK1_HUMAN
A:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASGN
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
89
HHSearch
61.90
37%
-18
- C9 -
-
2CUN
4
PGK_PYRHO
A:
[3-401]
----
R
L
E
--
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
-
D
G
K
-
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
-
T
H
Q
G
K
P
-------------
Y
-
S
E
D
------------------
Y
T
--
T
T
E
E
H
A
R
V
L
-----------
S
E
L
L
D
Q
H
V
E
Y
I
E
D
-
I
F
------
G
R
Y
A
R
E
K
I
K
------
E
L
----
K
-------
S
-------
G
E
V
A
I
L
E
N
L
R
F
S
---------------
A
E
----
E
----
V
-----------
K
----
N
---------------
K
P
I
E
E
C
E
K
T
-------
F
L
V
K
K
L
----
S
K
--------------
V
I
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
---
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
--
L
R
R
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
-------
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
-----
E
FY---
P
Y
--
I
R
T
P
V
D
F
A
V
D
Y
K
----
G
-
E
R
----------
V
E
I
D
L
L
S
E
N
-
R
G
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
----
V
-
E
V
F
K
A
I
A
---
D
----
S
--
P
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
-
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
-
29
PsiBlast_CBE
61.82
39%
8
- C9 -
-
2X15
2
PGK1_HUMAN
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKGK-------
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
86
HHSearch
61.55
42%
-4
- C9 -
-
2WZB
3
PGK1_HUMAN
A:
[6-415]
---
L
T
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
-
S
H
L
G
R
P
-------------
D
-
G
V
P
M
---------------
P
D
K
Y
--
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
------
G
P
E
V
E
K
A
C
A
------
N
P
----
A
-------
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
-----------
G
KG-------------------E
P
A
K
I
--
E
-------
A
F
R
A
S
L
----
S
K
--------------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
----
F
D
E
----------
N
A
K
T
G
Q
A
-
T
V
A
S
G
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
A
---
T
S
R
G
C
---
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--
19
PsiBlast_PDB
61.54
39%
3
- C9 -
-
2Y3I
2
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASGN
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
33
PsiBlast_CBE
61.30
39%
3
- C9 -
-
3ZOZ
3
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKG-----------------------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
14
PsiBlast_PDB
61.26
39%
-2
- C9 -
-
2ZGV
1
PGK1_HUMAN
A:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASGN
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
31
PsiBlast_CBE
61.06
39%
0
- C9 -
-
2WZC
2
PGK1_HUMAN
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKG-----------------------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
26
PsiBlast_CBE
61.06
39%
-9
- C9 -
-
3C3A
2
PGK1_HUMAN
B:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
----------------------------KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
AS
G
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
28
PsiBlast_CBE
61.04
39%
4
- C9 -
-
2Y3I
2
PGK1_HUMAN
D:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKGKDASGNKV
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
SLSK----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
AEKNG
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
RGC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
57
PsiBlast_CBE
60.97
34%
-18
- C9 -
-
2CUN
4
PGK_PYRHO
B:
[3-398]
----
R
L
E
--
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
-
D
G
K
-
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
-
T
H
Q
G
K
P
-------------
Y
-
S
E
D
Y
---------------
T
T
T
E
--
E
H
A
R
V
---
L
-----------
S
E
L
L
D
Q
H
V
E
Y
I
E
D
-
I
F
------
G
R
------
Y
AREKIK
E
L
----
K
-------
S
-------
G
E
V
A
I
L
E
N
L
R
F
S
---------------
A
E
----
E
----
V
-----------
K
----
N
---------------
K
-------
P
IEECEKT
F
L
V
K
K
L
----
S
K
--------------
V
I
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
M
--
I
M
-
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
LR
R
E
--
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
FMKKKGL
L
-------
D
Y
V
K
H
A
E
E
I
L
D
-----
E
-----
F
Y
PY
I
R
T
P
V
D
F
A
V
---------
D
Y
K
--
G
E
-
R
-
V
E
I
D
-
L
L
S
-
E
N
-
R
G
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
----
V
-
E
V
F
K
A
I
A
---
D
----
S
--
P
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
----
20
PsiBlast_PDB
60.96
39%
1
- C9 -
-
2WZB
3
PGK1_HUMAN
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKG-----------------------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
15
PsiBlast_PDB
60.85
39%
1
- C9 -
-
3C39
1
PGK1_HUMAN
A:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKGK-------
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
42
PsiBlast_CBE
60.76
39%
0
- C9 -
-
2X14
2
PGK1_HUMAN
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKG-----------------------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
32
PsiBlast_CBE
60.73
39%
9
- C9 -
-
4AXX
2
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKGK------------
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
30
PsiBlast_CBE
60.72
39%
8
- C9 -
-
2X13
2
PGK1_HUMAN
A:
[8-413]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKGK-------
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
24
PsiBlast_CBE
60.72
39%
6
- C9 -
-
3C3C
1
PGK1_HUMAN
B:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
---------------------------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
AS
G
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
41
PsiBlast_CBE
60.46
39%
1
- C9 -
-
2WZD
3
PGK1_HUMAN
A:
[9-414]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
K
A
C
ANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
GKG-----------------------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
75
HHSearch
60.18
45%
9
- C9 -
-
3ZLB
5
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
--
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
-
D
G
V
-
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
L
F
-
S
H
L
G
R
V
-------------
K
-
E
E
S
D
---------------
K
A
G
K
--
S
L
A
P
V
A
A
D
L
-----------
A
A
K
L
G
Q
D
V
V
F
P
G
V
-
T
R
------
G
A
E
L
E
A
A
I
N
------
A
L
----
E
-------
D
-------
G
Q
V
L
L
V
E
N
T
R
Y
E
---------------
D
V
DGKK
E
----
S
-----------
K
----
N
---------------
D
-------
P
-------
E
L
G
K
Y
W
----
A
S
--------------
L
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
--
V
E
K
--
A
V
A
G
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
--
L
E
--
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
-
Q
-
G
-
I
-
E
I
G
N
S
L
V
E
-------
E
-------
D
K
L
D
V
A
K
A
L
L
E
-----
K
AN---
G
K
--
L
I
L
P
V
D
S
K
E
A
N
A
----
F
A
G
Y
----------
T
E
V
R
D
T
-
E
G
-
E
A
V
S
E
G
F
L
G
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
----
I
-
G
V
M
D
A
I
V
---
K
Q---
P
--
G
V
---
K
S
---
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
-
50
PsiBlast_CBE
59.89
41%
14
- C9 -
-
1QPG
2
PGK_YEAST
A:
[8-414]
-----
V
Q
--
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
-
Y
V
V
L
A
S
H
L
G
Q
P
---------------
N
G
E
R
---------------
N
E
K
Y
--
S
L
A
P
V
A
K
E
L
-----------
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
-------
G
------
P
------
E
V
----
E
-------
A
A
V
K
A
SAP
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
E
----
E
----
E
G
S
R
K
V
DGQKV-
K
----
A
---------------
S
-------
K
-------
E
D
V
Q
K
F
R
H
E
L
S
S
--------------
L
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
-------
K
A
G
A
E
I
V
P
K
L
M
E
K
A
K
--
A
K
-----
G
-----
V
E
--
V
V
L
P
V
D
F
I
I
A
D
A
F
-----------
S
-
A
-
D
A
N
T
K
T
V
T
-
D
K
-
E
G
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
----
K
-
A
L
L
D
E
V
V
---
K
----
S
--
S
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
-
25
PsiBlast_CBE
59.80
39%
4
- C9 -
-
3C3B
1
PGK1_HUMAN
B:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
-
C
V
---------------------------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
88
HHSearch
59.51
43%
-7
- C9 -
-
3PGK
2
PGK_YEAST
A:
[8-416]
----
S
V
Q
--
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
-
S
H
L
G
R
P
-------------
N
-
G
E
R
----------------
N
E
K
Y
--
S
L
A
P
V
A
K
E
L
-----------
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
------
G
P
E
V
E
A
A
V
K
------
A
S
----
A
-------
P
-------
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
E
----
E
----
E
-----------
G
SRKV
D
G
Q
K
V
K
A
SK
E
D
-----
V
-------
Q
-------
K
F
R
H
E
L
----
S
S
--------------
L
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
-
E
N
T
-
E
I
G
D
S
I
F
D
-------
K
-------
A
V
G
P
E
I
A
K
L
M
E
-----
K
A
K
A
K
G
V
E
--
V
V
L
P
V
D
F
I
I
A
D
A
----
F
S
----------
A
S
A
N
T
K
T
V
-
T
D
K
E
G
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
----
K
-
A
L
L
D
E
V
V
---
K
S
---
S
AA
G
N
---
T
V
---
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
27
PsiBlast_CBE
59.18
39%
4
- C9 -
-
3C39
1
PGK1_HUMAN
B:
[12-417]
-----
L
D
--
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
V
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
V
E
L
-----------
K
S
L
L
G
K
D
V
L
F
L
K
D
------------------------------
E
KACANPA
A
-------
G
S
V
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G
K
G
K
D
ASG
N
K
V
K
----
A
---------------
E
-------
P
-------
A
K
I
E
A
F
----
R
A
S
L
S
K
----------
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
-------
E
-------
E
G
A
K
I
V
K
D
L
M
S
-----
K
A
E
K
N
G
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
--
A
T
-
V
-
A
S
G
-----------
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
----
53
PsiBlast_CBE
59.05
38%
7
- C9 -
-
2P9T
1
PGK2_MOUSE
A:
[8-413]
-----
L
D
--
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
I
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
D
E
L
-----------
K
S
L
L
N
K
D
V
I
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
-------
Q
A
C
ANPDN
G
S
I
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G----------
K
----
G
---------------
K
-------
D
-------
S
S
G
K
K
I
----
S
A
D
P
A
K
V
E
A
F
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
I
V
K
E
I
M
E
-----
K
A
E
K
N
G
V
K
--
I
V
F
P
V
D
F
V
T
G
D
K
-------
F
D
--
E
N
-
A
-
K
V
G
Q
A
T
I
E
----
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
N
G
C
V
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
----
52
PsiBlast_CBE
58.77
38%
7
- C9 -
-
2PAA
1
PGK2_MOUSE
A:
[8-413]
-----
L
D
--
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
I
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
D
E
L
-----------
K
S
L
L
N
K
D
V
I
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
-------
Q
A
C
ANPDN
G
S
I
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G----------
K
----
G
---------------
K
-------
D
-------
S
S
G
K
K
I
----
S
A
D
P
A
K
V
E
A
F
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
I
V
K
E
I
M
E
-----
K
A
E
K
N
G
V
K
--
I
V
F
P
V
D
F
V
T
G
D
K
-------
F
D
--
E
N
-
A
-
K
V
G
Q
A
T
I
E
----
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
N
G
C
V
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
----
49
PsiBlast_CBE
57.96
42%
-3
- C9 -
-
3PGK
2
PGK_YEAST
A:
[9-415]
-----
V
Q
--
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
-
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
-
Y
V
V
L
A
S
H
L
G
R
P
---------------
N
G
E
R
---------------
N
E
K
Y
--
S
L
A
P
V
A
K
E
L
-----------
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
-------
G
------
P
------
E
V
----
E
-------
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
E
----
E
----
E
GSRKV
D
G
Q
K
V
-
K
----
A
---------------
S
-------
K
-------
E
D
V
Q
K
F
R
H
E
L
S
S
--------------
L
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
K
A
V
G
P
E
I
A
-------
K
L
M
E
K
A
K
--
A
K
-----
G
-----
V
E
--
V
V
L
P
V
D
F
I
I
A
D
A
F
-----------
S
-
A
-
S
A
N
T
K
T
V
T
-
D
K
-
E
G
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
----
K
-
A
L
L
D
E
V
V
---
K
----
S
--
S
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
-
51
PsiBlast_CBE
57.48
38%
2
- C9 -
-
2PAA
1
PGK2_MOUSE
B:
[8-413]
-----
L
D
--
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
-
N
N
Q
-
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
-
V
V
L
M
-
S
H
L
G
R
P
---------------
D
G
I
P
---------------
M
P
D
K
Y-
S
L
E
P
V
A
D
E
L
-----------
K
S
L
L
N
K
D
V
I
F
L
K
D
-
C
V
-------
G
------
P
------
E
V
----
E
-------
Q
ACANPDN
G
S
I
I
L
L
E
N
L
R
F
H
---------------
V
E
----
E
----
E
G----------
K
----
G
---------------
K
-------
D
-------
S
S
G
K
K
I
----
S
A
DPAKVEAFRASLSK
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
-------
E
-------
E
G
A
T
I
V
K
E
I
M
E
-----
K
AEKNG
V
K
--
I
V
F
P
V
D
F
V
T
G
D
K
-------
F
D
--
E
N
-
A
-
K
V
G
Q
A
T
I
E
----
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
----
K
-
A
L
M
D
E
V
V
---
K
----
A
--
T
S
NGC
V
T
---
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
----
59
PsiBlast_CBE
46.81
40%
17
- C9 -
-
1FW8
4
PGK_YEAST
A:
[4-343]
--------------------------------------------------------------------------------------------------------------
S
L
A
P
V
A
K
E
L
-----------
Q
S
L
L
G
K
D
V
T
F
L
N
D
-
C
V
-------
G
------
P
------
E
V
----
E
-------
A
A
V
K
A
SAP
G
S
V
I
L
L
E
N
L
R
Y
H
---------------
I
E
----
E
----
E
G
S
R
K
V
DG
Q
K
V
-
K
----
A
---------------
S
-------
K
-------
E
D
V
Q
K
F
R
H
E
L
S
S
--------------
L
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
-------
K
A
G
A
E
I
V
P
K
L
M
E
K
A
K
--
A
K
-----
G
-----
V
E
--
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
------------
A
N
T
K
T
V
T
D
-
K
--
E
G
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
----
K
-
A
L
L
D
E
V
V
---
K
----
S
--
S
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
-