@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VND4: (2017-11-13 )
MAKQSAGQLFRDAVAQEKPLQVVGTINANHALLAKRAGYKAIYLSGGGVAAGSLGLPDLGISNLDDVLTDVRRITDVCDLPLLVDADTGFGASAFNIARTTKALIKFGAAAMHIEDQVGAKRCGHRPNKAIVTQEEMVDRIKAAVDARGDDSFVIMARTDALAVEGLQAAIDRAGAYIEAGADMLFPEAITELDMYKQFAQKTGVPILANITEFGSTPLFTTEELASADVSLALYPLSAFRAMNKAAETVYETLRKEGTQKNVVDIMQTRKELYERINYYAFEDYLDNAFAKKK
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70.....-...80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAK
Q
S
A
G
Q
L
F
R
D
A
VAQEKP
L
Q
V
V
G
T
INA
N
H
A
L
L
A
KRAG
Y
K
A
I
Y
LSGGGVAAGSLGLPDLGI
S
N
L
D
D
V
L
T
D
V
R
R
I
T
D
-VCDL
P
L
L
V
DADTGFGA
S
A
F
N
I
A
R
T
T
K
A
L
I
K
FGA
A
A
M
H
I
E
D
QV
G
A
K
RCGHRPNKAIV
T
Q
E
E
M
V
D
R
I
K
A
A
VDARGDD
S
F
V
I
M
ART
D
A
L
A
V
E
G
L
Q
A
A
I
D
RAG
A
Y
I
EAGADML
F
P
E
A
I
T
E
L
D
M
Y
K
Q
F
A
Q
KTGV
P
I
L
A
N
I
T
EFGSTPLF
T
T
E
E
L
ASAD
V
S
L
A
L
Y
P
L
S
A
F
R
A
M
N
K
A
A
E
T
V
Y
E
T
L
R
KEGTQ
K
N
V
V
D
I
M
Q
T
R
K
E
L
Y
E
R
I
N
Y
Y
A
F
E
D
Y
L
D
N
A
FAKKK
90
HHSearch
97.47
77%
-114
- C5 -
-
1OQF
-
PRPB_ECOLI
A:
[1-290]
-
S
L
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
C
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
L
F
A
---
4
PsiBlast_PDB
97.12
77%
-115
- C5 -
-
1OQF
-
PRPB_ECOLI
A:
[3-290]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
C
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
L
F
A
---
3
PsiBlast_PDB
96.35
77%
-116
- C5 -
-
1MUM
-
PRPB_ECOLI
A:
[3-290]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
C
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
L
F
A
---
29
PsiBlast_CBE
96.11
76%
-115
- C5 -
-
1XG3
2
PRPB_ECOLI
C:
[3-288]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
L
-----
26
PsiBlast_CBE
95.20
76%
-114
- C5 -
-
1XG4
1
PRPB_ECOLI
C:
[3-288]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
L
-----
6
PsiBlast_PDB
94.29
76%
-104
- C5 -
-
1XG4
2
PRPB_ECOLI
A:
[3-287]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
------
91
HHSearch
93.74
77%
-104
* C5 *
-
1XG4
2
PRPB_ECOLI
B:
[2-287]
--
L
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
------
27
PsiBlast_CBE
93.48
76%
-105
- C5 -
-
1XG4
2
PRPB_ECOLI
B:
[3-287]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
------
30
PsiBlast_CBE
93.24
76%
-105
- C5 -
-
1XG3
3
PRPB_ECOLI
B:
[3-287]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
------
5
PsiBlast_PDB
93.20
76%
-102
- C5 -
-
1XG3
3
PRPB_ECOLI
A:
[3-288]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
L
D
N
L
-----
22
PsiBlast_CBE
93.07
78%
-130
- C5 -
-
1O5Q
1
PRPB_SALTY
C:
[6-291]
---
H
S
P
G
Q
A
F
R
A
A
L
A
K
E
N
P
L
Q
I
V
G
A
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
P
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
I
A
K
A
G
A
A
A
L
H
I
E
D
Q
V
-----------
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
R
T
D
P
N
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
E
A
A
L
D
R
A
Q
A
Y
V
D
A
G
A
D
M
L
F
P
E
A
I
T
E
L
S
M
Y
R
R
F
A
D
V
A
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
K
V
Y
T
V
L
R
Q
E
G
T
Q
K
N
V
I
D
I
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
F
E
E
K
L
D
A
L
-----
23
PsiBlast_CBE
92.99
78%
-129
- C5 -
-
1O5Q
1
PRPB_SALTY
B:
[7-285]
----
S
P
G
Q
A
F
R
A
A
L
A
K
E
N
P
L
Q
I
V
G
A
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
P
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
I
A
K
A
G
A
A
A
L
H
I
E
D
Q
V
-----------
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
R
T
D
P
N
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
E
A
A
L
D
R
A
Q
A
Y
V
D
A
G
A
D
M
L
F
P
E
A
I
T
E
L
S
M
Y
R
R
F
A
D
V
A
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
K
V
Y
T
V
L
R
Q
E
G
T
Q
K
N
V
I
D
I
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
F
E
-----------
25
PsiBlast_CBE
92.73
76%
-104
- C5 -
-
1XG4
1
PRPB_ECOLI
D:
[3-284]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
---------
28
PsiBlast_CBE
92.49
76%
-102
- C5 -
-
1XG3
2
PRPB_ECOLI
D:
[3-284]
---
H
S
P
G
K
A
F
R
A
A
L
T
K
E
N
P
L
Q
I
V
G
T
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
S
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
M
I
K
A
G
A
A
G
L
H
I
E
D
Q
V
G
A
K
R
S
G
H
R
P
N
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
T
D
P
D
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
A
Y
V
E
A
G
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
F
A
D
A
V
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
D
T
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
Y
E
E
K
---------
2
PsiBlast_PDB
92.14
78%
-132
- C5 -
-
1O5Q
1
PRPB_SALTY
A:
[7-288]
----
S
P
G
Q
A
F
R
A
A
L
A
K
E
N
P
L
Q
I
V
G
A
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
P
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
I
A
K
A
G
A
A
A
L
H
I
E
D
Q
V
-----------
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
R
T
D
P
N
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
E
A
A
L
D
R
A
Q
A
Y
V
D
A
G
A
D
M
L
F
P
E
A
I
T
E
L
S
M
Y
R
R
F
A
D
V
A
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
K
V
Y
T
V
L
R
Q
E
G
T
Q
K
N
V
I
D
I
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
F
E
E
K
L
--------
1
PsiBlast_PDB
92.12
78%
-130
- C- -
-
1UJQ
-
PRPB_SALTY
A:
[4-286]
---
H
S
P
G
Q
A
F
R
A
A
L
A
K
E
N
P
L
Q
I
V
G
A
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
P
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
I
A
K
A
G
A
A
A
L
H
I
E
D
Q
V
-----------
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
R
T
D
P
N
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
E
A
A
L
D
R
A
Q
A
Y
V
D
A
G
A
D
M
L
F
P
E
A
I
T
E
L
S
M
Y
R
R
F
A
D
V
A
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
K
V
Y
T
V
L
R
Q
E
G
T
Q
K
N
V
I
D
I
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
F
E
E
K
L
--------
21
PsiBlast_CBE
91.77
78%
-129
- C5 -
-
1O5Q
1
PRPB_SALTY
D:
[6-284]
---
H
S
P
G
Q
A
F
R
A
A
L
A
K
E
N
P
L
Q
I
V
G
A
I
N
A
N
H
A
L
L
A
Q
R
A
G
Y
Q
A
I
Y
L
S
G
G
G
V
A
A
G
S
L
G
L
P
D
L
G
I
S
T
L
D
D
V
L
T
D
I
R
R
I
T
D
-
V
C
P
L
P
L
L
V
D
A
D
I
G
F
G
S
S
A
F
N
V
A
R
T
V
K
S
I
A
K
A
G
A
A
A
L
H
I
E
D
Q
V
-----------
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
R
T
D
P
N
F
V
I
M
A
R
T
D
A
L
A
V
E
G
L
E
A
A
L
D
R
A
Q
A
Y
V
D
A
G
A
D
M
L
F
P
E
A
I
T
E
L
S
M
Y
R
R
F
A
D
V
A
Q
V
P
I
L
A
N
I
T
E
F
G
A
T
P
L
F
T
T
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
S
A
F
R
A
M
N
R
A
A
E
K
V
Y
T
V
L
R
Q
E
G
T
Q
K
N
V
I
D
I
M
Q
T
R
N
E
L
Y
E
S
I
N
Y
Y
Q
F
------------
92
HHSearch
91.50
63%
-119
- C5 -
-
3EOO
-
?
A:
[6-294]
--
L
I
S
A
G
A
K
F
R
A
A
V
A
A
E
Q
P
L
Q
V
V
G
A
I
T
A
Y
A
A
K
M
A
E
A
V
G
F
K
A
V
Y
L
S
G
G
G
V
A
A
N
S
L
G
I
P
D
L
G
I
S
T
M
D
D
V
L
V
D
A
N
R
I
T
N
-
A
T
N
L
P
L
L
V
D
I
D
T
G
W
G
G
-
A
F
N
I
A
R
T
I
R
S
F
I
K
A
G
V
G
A
V
H
L
E
D
Q
V
G
Q
K
R
C
G
H
R
P
G
K
E
C
V
P
A
G
E
M
V
D
R
I
K
A
A
V
D
A
R
T
D
E
T
F
V
I
M
A
R
T
D
A
A
A
A
E
G
I
D
A
A
I
E
R
A
I
A
Y
V
E
A
G
A
D
M
I
F
P
E
A
M
K
T
L
D
D
Y
R
R
F
K
E
A
V
K
V
P
I
L
A
N
L
T
E
F
G
S
T
P
L
F
T
L
D
E
L
K
G
A
N
V
D
I
A
L
Y
C
C
G
A
Y
R
A
M
N
K
A
A
L
N
F
Y
E
T
V
R
R
D
G
T
Q
K
A
A
V
P
T
M
Q
T
R
A
Q
L
Y
D
Y
L
G
Y
Y
A
Y
E
E
K
L
D
Q
L
F
N
Q
--
7
PsiBlast_PDB
91.30
63%
-120
- C5 -
-
3EOO
-
?
A:
[8-295]
----
S
A
G
A
K
F
R
A
A
V
A
A
E
Q
P
L
Q
V
V
G
A
I
T
A
Y
A
A
K
M
A
E
A
V
G
F
K
A
V
Y
L
S
G
G
G
V
A
A
N
S
L
G
I
P
D
L
G
I
S
T
M
D
D
V
L
V
D
A
N
R
I
T
N
-
A
T
N
L
P
L
L
V
D
I
D
T
G
W
G
-
G
A
F
N
I
A
R
T
I
R
S
F
I
K
A
G
V
G
A
V
H
L
E
D
Q
V
G
Q
K
R
C
G
H
R
P
G
K
E
C
V
P
A
G
E
M
V
D
R
I
K
A
A
V
D
A
R
T
D
E
T
F
V
I
M
A
R
T
D
A
A
A
A
E
G
I
D
A
A
I
E
R
A
I
A
Y
V
E
A
G
A
D
M
I
F
P
E
A
M
K
T
L
D
D
Y
R
R
F
K
E
A
V
K
V
P
I
L
A
N
L
T
E
F
G
S
T
P
L
F
T
L
D
E
L
K
G
A
N
V
D
I
A
L
Y
C
C
G
A
Y
R
A
M
N
K
A
A
L
N
F
Y
E
T
V
R
R
D
G
T
Q
K
A
A
V
P
T
M
Q
T
R
A
Q
L
Y
D
Y
L
G
Y
Y
A
Y
E
E
K
L
D
Q
L
F
N
Q
G
-
93
HHSearch
91.14
63%
-117
- C5 -
-
3EOO
-
?
N:
[6-292]
--
L
I
S
A
G
A
K
F
R
A
A
V
A
A
E
Q
P
L
Q
V
V
G
A
I
T
A
Y
A
A
K
M
A
E
A
V
G
F
K
A
V
Y
L
S
G
G
G
V
A
A
N
S
L
G
I
P
D
L
G
I
S
T
M
D
D
V
L
V
D
A
N
R
I
T
N
-
A
T
N
L
P
L
L
V
D
I
D
T
G
W
G
G
-
A
F
N
I
A
R
T
I
R
S
F
I
K
A
G
V
G
A
V
H
L
E
D
Q
V
G
Q
K
R
C
G
H
R
P
G
K
E
C
V
P
A
G
E
M
V
D
R
I
K
A
A
V
D
A
R
T
D
E
T
F
V
I
M
A
R
T
D
A
A
A
A
E
G
I
D
A
A
I
E
R
A
I
A
Y
V
E
A
G
A
D
M
I
F
P
E
A
M
K
T
L
D
D
Y
R
R
F
K
E
A
V
K
V
P
I
L
A
N
L
T
E
F
G
S
T
P
L
F
T
L
D
E
L
K
G
A
N
V
D
I
A
L
Y
C
C
G
A
Y
R
A
M
N
K
A
A
L
N
F
Y
E
T
V
R
R
D
G
T
Q
K
A
A
V
P
T
M
Q
T
R
A
Q
L
Y
D
Y
L
G
Y
Y
A
Y
E
E
K
L
D
Q
L
F
----
100
HHSearch
77.99
43%
-113
- C5 -
-
4IQD
4
?
A:
[14-298]
--
Q
E
E
L
A
N
R
F
R
A
L
V
E
A
N
E
I
L
Q
I
P
G
A
H
D
A
M
A
A
L
V
A
R
N
T
G
F
L
A
L
Y
L
S
G
A
A
Y
T
A
S
-
K
G
L
P
D
L
G
I
V
T
S
T
E
V
A
E
R
A
R
D
L
V
R
-
A
T
D
L
P
V
L
V
D
I
D
T
G
F
G
G
-
V
L
N
V
A
R
T
A
V
E
M
V
E
A
K
V
A
A
V
Q
I
E
D
Q
Q
L
P
K
K
C
G
H
L
N
G
K
K
L
V
T
T
E
E
L
V
Q
K
I
K
A
I
K
E
V
A
--
P
S
L
Y
I
V
A
R
T
D
A
R
G
V
E
G
L
D
E
A
I
E
R
A
N
A
Y
V
K
A
G
A
D
A
I
F
P
E
A
L
Q
S
E
E
E
F
R
L
F
N
S
K
V
N
A
P
L
L
A
N
M
T
E
F
G
K
T
P
Y
Y
S
A
E
E
F
A
N
M
G
F
Q
M
V
I
Y
P
V
T
S
L
R
V
A
A
K
A
Y
E
N
V
F
T
L
I
K
E
T
G
S
Q
K
D
A
L
S
N
M
Q
T
R
S
E
L
Y
E
T
I
S
Y
H
D
F
E
E
L
D
T
G
I
A
K
---
8
PsiBlast_PDB
77.81
44%
-121
- C5 -
-
4IQD
4
?
A:
[21-298]
---------
F
R
A
L
V
E
A
N
E
I
L
Q
I
P
G
A
H
D
A
M
A
A
L
V
A
R
N
T
G
F
L
A
L
Y
L
S
G
A
A
Y
T
A
-
S
K
G
L
P
D
L
G
I
V
T
S
T
E
V
A
E
R
A
R
D
L
V
R
-
A
T
D
L
P
V
L
V
D
I
D
T
G
F
G
G
-
V
L
N
V
A
R
T
A
V
E
M
V
E
A
K
V
A
A
V
Q
I
E
D
Q
Q
L
P
K
K
C
G
H
L
N
G
K
K
L
V
T
T
E
E
L
V
Q
K
I
K
A
I
K
E
V
A
--
P
S
L
Y
I
V
A
R
T
D
A
R
G
V
E
G
L
D
E
A
I
E
R
A
N
A
Y
V
K
A
G
A
D
A
I
F
P
E
A
L
Q
S
E
E
E
F
R
L
F
N
S
K
V
N
A
P
L
L
A
N
M
T
E
F
G
K
T
P
Y
Y
S
A
E
E
F
A
N
M
G
F
Q
M
V
I
Y
P
V
T
S
L
R
V
A
A
K
A
Y
E
N
V
F
T
L
I
K
E
T
G
S
Q
K
D
A
L
S
N
M
Q
T
R
S
E
L
Y
E
T
I
S
Y
H
D
F
E
E
-
L
D
T
G
I
A
K
--
98
HHSearch
64.95
35%
-54
- C5 -
-
1ZLP
1
PDP_DIACA
B:
[28-312]
------
K
T
T
M
H
R
L
I
E
E
H
G
S
V
L
M
P
G
V
Q
D
A
L
S
A
A
V
V
E
K
T
G
F
H
A
A
F
V
S
G
Y
S
V
S
A
A
M
L
G
L
P
D
F
G
L
L
T
T
T
E
V
V
E
A
T
R
R
I
T
A
A
A
P
N
L
C
V
V
V
D
G
D
T
G
G
G
G
-
P
L
N
V
Q
R
F
I
R
E
L
I
S
A
G
A
K
G
V
F
L
E
D
Q
V
W
P
K
K
C
G
H
M
R
G
K
A
V
V
P
A
E
E
H
A
L
K
I
A
A
A
R
E
A
I
G
D
S
D
F
F
L
V
A
R
T
D
A
R
A
P
H
G
L
E
E
G
I
R
R
A
N
L
Y
K
E
A
G
A
D
A
T
F
V
E
A
P
A
N
V
D
E
L
K
E
V
S
A
K
T
K
G
L
R
I
A
N
M
I
E
G
G
K
T
P
L
H
T
P
E
E
F
K
E
M
G
F
H
L
I
A
H
S
L
T
A
V
Y
A
T
A
R
A
L
V
N
I
M
K
I
L
K
E
K
G
T
T
R
D
D
L
D
Q
M
A
T
F
S
E
F
N
E
L
I
S
L
E
S
W
Y
E
M
E
S
K
F
K
N
---