@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP42: (2017-11-19 )
MNMAEEVHHAPNLKRSKYFATMALIIVVVLWIGLLITNRFLPEYTDLIHILMLGAEAGVVGGLADWYAITILFRNPFGKLPIPKFLRDHTEIIPRNKARIAESMGRFVQENFLSPQVVERSLEKTDLSLAIGQWLASPQNNTQVVQLIQQTVPKVFEFVSQEQIANFVQNNSVQWVRNTQVNKLASEMLRAVLENDFHQDVLQRGLDIAHEWVVQNPDKTRELTRKMFKALGVWSLAKGASWIGIDVQQRTIDSLVEKVESMLADHEHPWRQEIETIAHSLMLELANPESIASQRLNSGKDALLDSPQVLNFISGAVTILCDAIKEDLMKEDSGIAMNLRAAIQQLGENLVQNVKVREVLNKEMTGLAMNFTDQYSHKIIRYVSERIHEWDSREMIGKIENEVGGDLHMIRVNGVVVGAFIGLTLGVIRAAIESIL
Atome Classification :
(20 SA)
----------------------------------------------.........10........20........30..-......40....-....50---------........60.....----..---.70........80..-----......90....---....---100...--....110--.......120.......130.......140-..-......150...-----------....160-----------.-------......170..---.....180....-...190...----.----...200......--.210-...--....220.-......230.......240......--.250.......260...-..------------------..270......----------.280......--..-----------290.......----------------300...-....310......---.320.......330.......340..--.....350.....----------------..360----.......370...--...----------------.380.......390.....---------------..400.......410--.......420.......430....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------M
N
M
A
E
E
V
H
HAPNL
K
R
S
K
Y
F
A
T
M
A
L
I
I
V
V
V
L
W
I
G
-
L
L
I
T
NRF
L
P
E
Y
T
-
D
L
I
H
I
L
---------
M
LGAEAGVVGGLAD
W
----
Y
A
---
I
T
I
L
F
RNPFGKL
P
I
P
-----
K
F
L
R
D
H
T
E
IIPR---
N
K
A
R
---
I
A
E
S
M
G
--
R
F
V
Q
E
NF--L
S
P
Q
V
V
E
R
S
L
E
KT
D
L
S
L
A
I
G
Q
W
LASPQN
N
--
T
Q
-
V
V
Q
L
I
Q
Q
T
V
P
K
V
-----------
F
E
F
V
S
Q
E
-----------
Q
-------
I
A
N
F
V
QNNS
V
Q
---
W
V
RNT
Q
V
N
K
L
A
S
-
E
M
L
R
A
V
L
E
N
----
D
----
F
H
Q
D
V
L
Q
R
G
L
D
I
--
A
H
E
W
-VVQ--NP
D
K
T
R
E
L
-
T
R
K
M
F
K
A
L
G
V
W
S
LAKG
A
S
W
I
G
I
D
V
Q
--
Q
R
T
I
D
S
L
V
E
K
V
E
S
M
L
AD-HE------------------H
P
W
R
Q
E
I
E
T
I
A
----------
H
S
L
-
M
L
ELA
N
--
P
E
-----------
S
I
A
S
Q
RLNSG----------------KDALLD-
S
P
Q
V
L
N
F
I
S
G
A
V
T
---
I
L
C
D
A
I
K
E
D
L
M
KEDSG
I
A
M
N
L
R
A
A
I
Q
--
Q
L
G
E
N
L
V
Q
N
V
K
V
R
----------------
E
V
L
N
K
----
E
MTGLAMN
F
T
D
Q
Y
--
S
H
K
----------------
I
I
R
Y
V
S
E
R
I
HEW
D
S
R
E
M
I
G
---------------
K
I
E
N
EVGG
D
L
H
M
I
R
V--N
G
V
V
V
G
A
F
I
G
L
T
L
G
V
I
R
A
A
I
E
SIL-
22
Fugue
69.21
16%
-19
- C3 -
-
4XDN
-
SCC4_YEAST
A:
[24-640]
G
D
K
L
S
I
S
Q
V
Y
H
L
A
Q
E
Y
R
D
H
A
Y
S
I
A
NKIGS
E
E
G
L
K
Q
Y
Y
G
L
M
N
M
S
I
Q
M
F
Q
L
L
K
T
K
C
T
L
S
V
L
E
D
S
K
V
T
F
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M
V
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L
L
I
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Y
-
N
-
F
D
L
A
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L
Y
I
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S
L
K
-
E
R
L
Q
T
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QSDTDL
V
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E
I
M
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C
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F
L
L
L
H
D
L
P
L
M
R
DS
K
F
H
---
Y
K
I
A
L
R
N
C
N
E
L
V
Q
Y
M
V
N
LQD
E
L
Y
Q
N
W
A
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V
F
Q
Y
---
V
G
V
M
---
L
C
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K
L
K
Q
H
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R
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K
T
S
F
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L
L
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Q
C
R
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K
S
Q
W
K
W
F
L
N
L
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Y
V
N
Y
L
L
N
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R
F
P
IP
E
D
-
A
L
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T
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VG
P
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L
Y
A
W
K
L
A
L
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M
V
I
Q
L
C
K
DGNI
T
D
H
L
N
E
-------
F
K
N
F
F
D
T
N
K
Q
S
---
L
V
T
N
E
G
K
G
C
V
I
K
-
I
M
P
R
I
A
L
K
V
----
E
L
PMI
F
H
Y
K
E
L
K
N
I
L
L
L
L
Q
S
V
S
Y
-
I
V
N
--
C
Y
D
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K
G
N
F
-
S
R
K
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L
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K
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Y
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K
L
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K
N
I
A
A
G
G
V
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--
M
N
E
L
D
S
R
I
Q
T
Y
K
S
I
L
E
F
-
C
E
------------------
F
Y
K
V
W
E
Q
T
L
L
K
GAVVLGPSPG
Y
V
R
-
L
L
Q
A
M
K
--
V
Q
F
E
GGGA
V
E
E
Y
T
R
L
A
Q
S
G
G
T
S
S
----------------
E
V
K
M
I
S
-
L
L
N
C
Y
T
V
Q
A
A
R
V
S
---
R
C
S
G
D
K
Q
G
E
L
V
E
Q
C
N
K
V
W
L
Q
V
E
K
L
L
Q
E
T
D
L
Q
F
N
P
I
W
E
C
T
V
T
I
L
W
L
F
S
H
F
EPFSWNPL
P
C
S
D
K
----
Q
R
A
E
Y
V
S
K
L
R
E
F
Y
--
S
S
N
KFVNRFKLKKA
L
L
L
Q
I
L
V
N
Y
L
G
G
R
M
L
E
H
D
L
G
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I
Y
A
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S
A
K
C
F
D
M
C
R
QQGGM
R
K
V
Q
Y
V
I
G
I
W
H
L
M
N
C
--
T
V
A
M
R
G
K
D
V
A
L
T
N
A
K
L
E
A
L
V
K
Q
I
T
S
20
Fugue
59.12
19%
19
- C4 -
-
2I3O
-
?
D:
[2-516]
------------------------------------FRSRPNALSQ
R
S
V
I
A
S
S
S
E
L
A
S
L
A
G
R
D
I
L
K
R
G
G
N
I
F
D
A
A
L
A
V
S
A
L
C
V
T
Q
N
N
L
C
G
L
G
G
D
L
F
A
L
I
RDENGQID-
L
N
G
S
G
Q
A
S
R
A
V
S
I
D
Y
----
Y
E
SGL
T
K
I
P
E
R
G
P
Y
A
A
I
T
V
P
-----
G
I
A
G
S
W
D
E
I
F
R
K
FAT
D
I
A
D
---
I
L
E
P
A
I
--
R
T
A
S
A
G
F
--
P
I
T
Q
N
Y
S
D
S
I
A
R
S
A
P
V
I
G
Q
Y
R
G
W
S
S
I
F
P
N
-----------
G
S
V
P
V
A
-----------
G
E
I
L
K
Q
P
-----------
D
-------
L
A
E
S
F
R
L
S
E
E
G
---
F
--
R
S
F
Y
D
G
S
L
A
-
D
I
I
I
A
G
L
E
G
----
T
GSP-
L
S
D
R
D
L
R
V
Y
R
P
L
--
I
G
K
P
-
V
F
T
--
D
L
D
E
F
R
I
Y
E
T
S
P
N
S
Q
G
I
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W
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H
-
G
Y
D
S
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TW
E
A
K
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E
A
Y
D
K
R
-
R
K
ITDPSYNIAQHDSANGKG
L
P
K
R
D
H
-
N
D
I
G
----------
D
T
T
-
Y
F
S
I
S
D
--
S
E
GR---------
S
V
S
I
I
Q
S
N
Y
G
FGSGIVPKGTGFVLQN
R
G
S
Y
F
T
L
Q
R
D
H
P
N
A
L
P
G
K
R
T
FHT
L
A
A
C
V
E
K
E
H
D
L
Y
A
S
L
G
S
G
G
D
I
Q
P
Q
V
Q
--
Q
I
L
E
I
L
K
D
N
T
D
P
Q
----------------
A
I
L
D
K
PRWT
E
P
Y
T
I
Y
E
A
P
G
A
V
Y
VE
S
E
E
----------------
L
Y
R
N
V
S
K
Q
I
---
S
G
R
K
V
V
L
---------------
R
D
V
S
Q
E
F
G
T
A
Q
I
T
T
L
IR
G
D
V
V
V
G
A
A
D
P
R
G
D
G
I
A
I
P
Y
S
-----
14
Fugue
49.40
17%
2
- C5 -
-
4DO7
-
?
A:
[3-289]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
L
R
I
D
S
H
Q
H
F
W
R
Y
---
R
A
A
D
YPW
I
G
A
G
M
G
--
V
L
A
R
D
Y
L
----
P
D
A
L
H
P
L
M
H
A
Q
A
L
G
A
S
I
A
V
Q
A
R
A
G
R
D
E
--
T
A
-
F
L
L
E
L
A
C
D
E
A
R
I
-----------
A
A
V
V
G
W
E
-----------
D
-------
L
R
A
P
Q
L
A
E
R
V
A
---
E
W
R
G
T
K
L
R
G
F
R
H
-
Q
L
Q
D
---
E
A
----
D
----
V
R
A
F
V
D
D
A
D
F
A
R
--
G
V
A
W
-
L
Q
A
--
N
D
Y
--------------------------
V
Y
D
V
L
----
V
F
E
R
Q
L
P
D
V
Q
A
F
C
A
R
-
H
D
------------------
A
H
W
----
L
V
L
D
----------
H
A
G
-
K
P
A
L
A
E
--
F
D
-----------
T
-
A
L
A
R
W
R
A
A
----------------
L
R
E
L
A
A
-
L
P
H
V
V
C
K
L
S
G
L
V
T
---
E
-
A
D
W
R
R
G
L
R
A
S
D
L
R
H
I
E
Q
C
L
D
A
A
L
D
--
A
F
G
P
Q
R
L
M
F
G
----------------------
S
D
----
W
P
V
C
L
L
A
A
S
Y
D
E
V
--
A
S
L
----------------
V
E
R
W
A
E
S
R
L
S
A
A
E
R
S
A
L
W
G
---------------
G
T
A
A
R
C
Y
A
L
P
--------------------------------
21
Fugue
38.96
25%
-271
- C- -
-
1G39
-
HNF1A_MOUSE
A:
[1-28]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
S
K
L
S
Q
L
Q
T
-
E
L
L
A
A
L
L
E
S
----
G
----
L
S
K
E
A
L
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
36.42
16%
-98
- C5 -
-
3ZTA
-
?
A:
[8-146]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
N
I
V
E
K
A
-----------
I
N
L
L
S
K
E
-----------
D
-------
Q
A
G
------------
V
H
F
N
E
I
S
A
L
T
R
-
D
F
C
R
A
I
L
S
D
L
E
QS
G
----
F
T
T
S
E
L
E
K
E
I
A
D
--
K
V
K
I
M
F
A
Q
GY
H
I
E
V
L
Q
L
I
-
L
E
K
I
L
D
S
F
I
S
V
I
R
E
Q
Y
H
D
L
Q
A
A
A
S
Y
--
I
T
T
V
R
D
H
I
F
K
G
T
S
F
L
L
K
M
A
L
------------------
Q
T
Q
R
E
V
I
Q
K
Q
N
----------
E
A
L
M
E
L
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
34.03
30%
-262
- C5 -
-
1F93
-
HNF1A_MOUSE
H:
[5-30]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
Q
L
Q
T
-
E
L
L
A
A
L
L
E
S
----
G
----
L
S
K
E
A
L
I
Q
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
33.19
29%
-213
- C5 -
-
1F93
-
HNF1A_MOUSE
G:
[4-30]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
Q
L
Q
T
-
E
L
L
A
A
L
L
E
S
----
G
----
L
S
K
E
A
L
I
Q
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
28.97
24%
2
- C5 -
-
1R6A
1
?
A:
[170-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
S
---
N
N
--
T
Q
F
C
V
K
V
L
N
P
Y
M
P
S
V
-----------
I
E
K
M
E
A
L
-----------
Q
R
K
H
G
G
A
L
V
R
N
P
L
S
R
N
S
T
H
EMY
W
V
S
N
A
S
G
N
I
V
S
S
V
N
M
I
S
R
M
L
I
N
----
R
----
F
---------
T
M
--
R
H
K
K
-
A
T
Y
--
E
P
D
V
----------------
D
L
G
S
G
T
R
N
I
G
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
28.76
31%
-351
- C5 -
-
2RMZ
-
?
A:
[696-708]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
L
S
V
M
G
A
I
L
L
I
G
-------------
13
Fugue
27.35
22%
-
- C5 -
-
3M8E
-
?
A:
[-15-102]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
T
L
---
N
I
A
E
---
I
A
E
R
I
G
------
N
D
D
--
C
A
Y
Q
V
L
M
A
F
I
N
E
N
G
E
--------
A
Q
M
L
N
K
--
T
A
-
V
A
E
M
I
Q
L
S
K
P
T
V
-----------
F
A
T
V
N
S
F
-----------
Y
-------
C
A
G
Y
I
D
E
T
R
V
G
---
R
S
K
I
Y
T
L
S
D
L
G
V
-
E
I
V
E
C
F
K
Q
K
----
A
----
M
E
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
27.02
22%
-148
* C5 *
-
2GYP
-
HNF1A_HUMAN
A:
[2-33]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
L
S
Q
L
Q
T
-
E
L
L
A
A
L
L
E
S
----
L
----
S
K
E
A
L
I
Q
A
L
G
E
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
21.84
17%
116
- C1 -
-
1G9P
-
TOT2A_HADVE
A:
[34-39]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
L
V
G
G
--------------
2
PsiBlast_PDB
20.43
33%
111
- C5 -
-
3N54
-
GERBC_BACSU
B:
[15-119]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
N
D
----------
H
Q
Y
-
K
L
T
Y
Q
N
LL
P
Q
-----------
S
--------
G
----------------
K
-------
P
E
F
V
N
V
T
S
H
G
K
T
---
I
L
-
E
A
V
S
D
V
S
I
K
D
P
P
V
Y
S
D
H
L
K
V
I
L
----
L
G
E
K
L
M
R
N
Q
N
V
D
----------------
Q
V
L
N
-------------------------------------------------------------------------------------------------------------------
6
HHSearch
17.17
8%
-92
- C5 -
-
1Y9W
-
?
A:
[7-59]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
G
--
T
R
I
----------------
E
G
E
Y
I
K
N
K
V
I
Q
Y
N
M
S
I
L
T
D
---------------
E
V
K
Q
P
M
E
E
V
S
L
V
V
K
N
E-
E
G
K
I
F
G
G
V
T
G
T
M
-------------
4
HHSearch
15.29
9%
-60
- C2 -
-
2M20
-
EGFR_HUMAN
A:
[3-13]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
A
T
G
L
V
G
A
L
-------------
11
HHSearch
12.04
17%
-16
- C5 -
-
5LV6
-
B:
[11-22]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
A
T
G
M
V
G
A
L
L
------------
5
HHSearch
10.30
25%
-
- C5 -
-
2N2A
-
B:
[109-120]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
I
I
S
A
V
V
G
I
L
L
------------
7
HHSearch
8.80
15%
-
- C5 -
-
1IIJ
-
A:
[8-20]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
I
I
A
T
V
V
G
V
L
L
F
-----------
3
HHSearch
6.43
42%
-
- C5 -
-
5JYN
-
?
B:
[3-21]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
Y
I
R
I
--
F
I
I
I
V
G
S
L
I
G
L
R
I
------------
10
HHSearch
4.74
4%
-
- C5 -
-
4O8W
-
?
D:
[155-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
E
T
L
N
S
P
L
Y
Q
----------------
A
K
I
Q
D
----
M
L
M
K
A
A
E
-------------------------------------------------------------------------------------------------------