@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPT5: (2017-11-23 )
MCGIVGGVAERCVTEILIEGLKRLEYRGYDSAGVALLNNQQILRERRVGKVANLADAVSEHQLTGAIGIAHTRWATHGKPTENNAHPHMSGKVAVVHNGIIENYQELKDDLQALGYVFTSQTDTEVVAHLVAEALKNTDSLLEAVESVVPQLKGAYALGIIHSDYPDELITVREGSPLVIGVGIGENFISSDQLALLPVTNRFIYLEEGDIARLTRTSIEVFVKGERVERPVKELDATVSSASKGEYKHYMLKEIYEQPEAIKQTISQALDGNNLRDDFLKDADADFSKLQSVQIIACGTSYHSGMIAKYWFEQLIGVPCQVEIASEFRYRSPVIVENTLYICISQSGETADTLAALRETQKRAKANNIDIQTLTICNVATSSMVRETDHHLLTLAGPEIGVASTKAFTTQLAALMLLILKIGQVKQRISNVMIEELARELWHSPKVILDTLKNDPEILRLSELFVEKQHCLFLGRGTHYPIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPIVILAPNDEMLDKLKSNMEEVQARGGELFVFADENSGVVEKDRQHVVHTPAVNEWLAPIIYSVPVQLLSYHVAVLRGTDVDQPRNLAKSVTVE
Atome Classification :
(29 SA)
.........10........20........30.......-.40.........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..-..--...230.......240.......250.......260.......270..--......--280-.......290.......300.......310.......320......-.330.......340.......350.......360.......370........380.......390.......400.......410.......420.......430..------.....440--.........450.....---..460.......470..-.....480.......490.......500.......510.......520.......530.......540-.......550.......560..-.....570-.........580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MCG
I
V
G
G
V
A
E
R
C
V
T
E
I
L
I
E
G
L
K
R
L
EYRGYDSA
G
V
A
L
LN-
N
Q
-
Q
I
L
R
E
RRV
G
K
V
A
N
L
A
D
A
V
S
E
HQLTGAIGI
A
H
T
RWATHGKPTENNAHPHMS
G
K
V
A
V
V
H
N
G
I
I
E
N
Y
Q
E
L
K
D
D
L
Q
A
L
G
Y
VFTSQT
D
T
E
V
V
A
H
L
V
A
E
A
LK
N
T
D
S
L
L
E
A
V
E
S
V
V
P
Q
LKG
A
Y
A
L
G
I
IHSDYPD
E
L
I
T
VREGS
P
L
V
I
G
V
GIGENFISSD
Q
L
A
L
L
P
VT
N
R
F
I
Y
LEEG
D
I
A
R
L
T
R
T
S
I
E
V
F
V
K-
G
E
--
R
VER
P
V
K
E
L
D
A
T
VSSASKG
E
Y
K
H
Y
M
L
K
E
I
YEQ
P
E
A
I
K
Q
T
I
S
Q
ALD-GN--N
L
R
D
D
F
--
L
KD-ADA
D
F
S
K
L
Q
S
V
Q
I
I
A
CGTSYHS
G
M
I
A
K
Y
W
F
E
Q
L
IGV
P
C
Q
V
E
I
A
S
EF-RYRS
P
V
I
V
EN
T
L
Y
I
C
ISQSGE
T
A
D
T
L
A
A
L
R
E
T
Q
K
RAKANN
I
D
I
-
Q
T
L
T
I
C
NV
A
T
S
S
M
V
R
ETDH
H
L
L
T
LAGPEIGVA
S
T
K
A
F
T
T
Q
L
A
A
L
M
L
L
I
L
K
I
G
Q
V
K
Q
R
I
S
N
V
M
I
------
E
E
L
A
R
E
----
L
WHS
P
K
V
I
L
D
T
LKN
D
P
E
---
I
L
R
L
S
E
L
F
V
EKQ
H
C
L
F
L-GRGTHY
P
I
A
LEG
A
L
K
L
K
E
I
S
Y
I
HAEGYAAGELKHG
P
L
A
L
VDNEM
P
I
V
I
LAP
N
D
E
M
L
D
K
L
K
S
N
M
E
E
V
Q
A-RG
G
E
L
F
V
F
ADENSGV
V
E
KDRQ
H
-
V
VHTP
A
---
V
N
E
W
L
A
P
I
I
Y
S
V
P
V
Q
L
L
S
Y
H
V
A
VLRGTDVD
Q
P
R
N
L
A
K
SVTVE
25
PsiBlast_CBE
83.35
57%
-18
- C2 -
-
2J6H
3
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
26
PsiBlast_CBE
83.06
57%
-20
- C2 -
-
3OOJ
14
GLMS_ECOLI
H:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
27
PsiBlast_CBE
82.94
57%
-20
- C2 -
-
3OOJ
14
GLMS_ECOLI
G:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
---
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
3
PsiBlast_PDB
82.84
57%
-16
- C2 -
-
2J6H
3
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
1
PsiBlast_PDB
82.69
57%
-19
- C2 -
-
4AMV
1
GLMS_ECOLI
A:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
32
PsiBlast_CBE
82.48
57%
-20
- C2 -
-
3OOJ
7
GLMS_ECOLI
B:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
6
PsiBlast_PDB
82.47
57%
-19
- C2 -
-
3OOJ
7
GLMS_ECOLI
A:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
21
PsiBlast_CBE
82.29
57%
-19
- C2 -
-
4AMV
2
GLMS_ECOLI
C:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
29
PsiBlast_CBE
81.60
57%
-18
- C2 -
-
3OOJ
2
GLMS_ECOLI
E:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
30
PsiBlast_CBE
81.58
57%
-18
- C2 -
-
3OOJ
7
GLMS_ECOLI
D:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
------
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
22
PsiBlast_CBE
81.36
57%
-21
- C2 -
-
4AMV
2
GLMS_ECOLI
B:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
31
PsiBlast_CBE
80.41
57%
-17
- C2 -
-
3OOJ
7
GLMS_ECOLI
C:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
-------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
28
PsiBlast_CBE
79.82
57%
-16
- C2 -
-
3OOJ
1
GLMS_ECOLI
F:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
--------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
2
PsiBlast_PDB
79.22
57%
-18
- C2 -
-
1JXA
1
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
24
PsiBlast_CBE
77.93
57%
-18
- C2 -
-
1JXA
1
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
23
PsiBlast_CBE
76.91
57%
-22
- C2 -
-
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
-
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
--
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
58
HHSearch
75.66
59%
-4
- C2 -
-
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
-
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
-
D
-
K
T
GA
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
-
H
G
--
Q
V
D
L
S
E
--
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
----
L
G
--
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
-
S
I
E
------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
8
PsiBlast_PDB
61.35
56%
-40
- C2 -
-
1MOQ
3
GLMS_ECOLI
A:
[3-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
7
PsiBlast_PDB
61.12
56%
-38
- C2 -
-
1MOS
2
GLMS_ECOLI
A:
[2-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
9
PsiBlast_PDB
60.79
56%
-37
- C2 -
-
1MOR
1
GLMS_ECOLI
A:
[3-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
5
PsiBlast_PDB
60.10
57%
-39
- C2 -
-
2VF5
1
GLMS_ECOLI
X:
[243-608]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
--
V
D
L
S
E
L
--
G
P
N
-
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-----
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
-------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
67
HHSearch
58.42
58%
-15
- C2 -
-
1MOQ
3
GLMS_ECOLI
A:
[3-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
-
H
G
--
Q
V
D
L
S
E
--
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
----
L
G
--
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
-
S
I
E
------
H
D
I
V
H
G
----
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
---
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
H
---
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
62
HHSearch
51.88
40%
-14
* C2 *
-
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
-
F
D
DY
T
V
N
L
G
G
--
L
K
D
-
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
----
R
G
--
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
-
Q
E
R
R
------
K
E
I
M
L
G
----
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
---
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
-
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
-
E
T
I
K
N
T
K
R
-
T
I
K
V
P
H
---
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
14
PsiBlast_PDB
51.33
40%
-10
- C2 -
-
2ZJ3
1
GFPT1_HUMAN
A:
[12-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
-
F
D
--
D
Y
T
V
N
L
GG
L
K
D
-
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
L
-------
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
--
C
D
D
R
I
S
---
M
------
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
---
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
-
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
-
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
E
T
I
K
N
T
K
R
-
T
I
K
V
P
H
---
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
38
PsiBlast_CBE
50.87
42%
-27
- C2 -
-
2PUW
1
GFA1_CANAL
B:
[4-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
S
A
F
N
T
M
R
G
R
I
D
-
F
E
--
N
C
V
V
T
L
GG
L
K
S
-
W
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
S
P
V
F
R
D
D
T
C
-
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
L
-------
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
-------
S
N
D
S
I
SR
K
G
R
H
E
E
I
I
K
G
----
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
---
I
K
D
L
C
N
S
S
---
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
-
R
D
G
R
P
I
V
I
C
N
E
G
D
-------
V
H
T
T
L
E
V
P
E
---
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
63
HHSearch
50.79
40%
-10
- C2 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
-
F
D
DY
T
V
N
L
G
G
--
L
K
D
-
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
----
R
G
--
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
-
Q
E
R
R
------
K
E
I
M
L
G
----
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
---
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
-
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
-
E
T
I
K
N
T
K
R
-
T
I
K
V
P
H
---
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
15
PsiBlast_PDB
50.49
40%
-9
- C2 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[12-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
-
F
D
--
D
Y
T
V
N
L
GG
L
K
D
-
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
L
-------
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
--
C
D
D
R
I
S
---
M
------
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
---
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
-
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
-
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
E
T
I
K
N
T
K
R
-
T
I
K
V
P
H
---
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
20
PsiBlast_PDB
50.08
42%
-19
- C2 -
-
2PUW
2
GFA1_CANAL
A:
[4-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
S
A
F
N
T
M
R
G
R
I
D
-
F
E
--
N
C
V
V
T
L
GG
L
K
S
-
W
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
S
P
V
F
R
D
D
T
C
-
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
L
-------
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
-------
S
N
D
S
I
SR
K
G
R
H
E
E
I
I
K
G
----
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
---
I
K
D
L
C
N
S
S
---
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
---------
E
D
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
-
R
D
G
R
P
I
V
I
C
N
E
G
D
A
I
I
S
N
D
K
V
H
T
T
L
E
V
P
E
---
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
53
Fugue
31.33
60%
-15
- C2 -
-
1MOQ
3
?
?:
[186-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
S
I
E
H
D
I
V
------
H
G
L
Q
A
L
----
P
S
R
I
E
Q
M
L
S
Q
D
------
K
R
I
E
-
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
-
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
-
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
-
I
I
E
M
P
-HVE--
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E