@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ53: (2017-11-25 )
MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDELDQVPDDSIVIFSAHGVSKAVQQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIGHEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPEKLAFVTQTTLSIDDTAKVIDALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMGKAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREENITFSLPKELRIHVTQA
Atome Classification :
(63 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......-.290----........300........310....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-
M
E
I
V
LANPR
G
F
C
A
G
V
D
R
A
I
A
I
V
N
R
A
L
E
CFNP
P
I
Y
V
R
H
E
V
VHN
K
F
V
V
D
D
L
R
QRG
A
V
F
V
D
E
L
DQVPDD
S
I
V
I
F
SAHG
V
S
K
A
V
Q
Q
E
A
E
RRG
L
K
V
FDATCP
L
V
T
K
V
H
I
E
V
T
K
YAREG
T
E
A
I
L
IGHEGHPEVEGTMGQYDKLKGG
D
I
Y
L
VEDEA
D
V
A
A
L
E
VRHPE
K
L
A
F
V
T
Q
T
T
LSI
D
D
T
A
K
V
I
D
A
L
R
A
KFPNIQGPRKDD
I
C
Y
ATQ
N
R
Q
D
A
V
R
D
L
A
E
KC
D
V
V
L
V
VGSPNSS
N
S
N
R
L
R
E
L
A
E
R
MGK
A
A
Y
LVD
N
A
D
Q
L
E
Q
S
WFNDT
C
K
I
G
VTAGAS
A
P
E
I
L
I
K
Q
V
I
Q
R
L
Q
D
WGA-QA
P
-----
K
E
LEGREE
N
I
-
T
F
SLPK
E
L
R
I
H
V
TQA
29
PsiBlast_CBE
93.20
64%
-107
- C7 -
-
4MV5
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
28
PsiBlast_CBE
93.18
64%
-105
- C7 -
-
3F7T
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
34
PsiBlast_CBE
93.12
64%
-105
- C7 -
-
3UWM
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
33
PsiBlast_CBE
93.07
64%
-109
- C7 -
-
4EB3
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
31
PsiBlast_CBE
93.04
64%
-109
- C7 -
-
4MUY
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
35
PsiBlast_CBE
93.02
64%
-108
- C7 -
-
3UV7
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
38
PsiBlast_CBE
92.80
64%
-107
- C7 -
-
3UTD
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
11
PsiBlast_PDB
92.54
64%
-107
- C7 -
-
4MV0
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
24
PsiBlast_CBE
92.51
64%
-105
- C7 -
-
3ZGN
2
ISPH_ECOLI
B:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
25
PsiBlast_CBE
92.40
64%
-104
- C7 -
-
3ZGL
2
ISPH_ECOLI
B:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
52
PsiBlast_CBE
92.36
64%
-105
- C7 -
-
3SZU
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
13
PsiBlast_PDB
92.32
64%
-107
- C7 -
-
4MV5
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
7
PsiBlast_PDB
92.30
64%
-102
- C7 -
-
3SZL
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
12
PsiBlast_PDB
92.28
64%
-105
- C7 -
-
4MUX
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
27
PsiBlast_CBE
92.27
64%
-106
- C7 -
-
3SZL
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
39
PsiBlast_CBE
92.23
64%
-106
- C7 -
-
3UTC
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
44
PsiBlast_CBE
92.20
64%
-103
- C7 -
-
3KEL
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
32
PsiBlast_CBE
92.19
64%
-108
- C7 -
-
4MUX
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
30
PsiBlast_CBE
92.15
64%
-107
- C7 -
-
4MV0
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
10
PsiBlast_PDB
92.04
64%
-105
- C7 -
-
4MUY
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
40
PsiBlast_CBE
92.02
64%
-105
- C7 -
-
3URK
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
50
PsiBlast_CBE
91.98
64%
-100
- C7 -
-
3KE8
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
20
PsiBlast_PDB
91.98
64%
-104
- C7 -
-
3UWM
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
26
PsiBlast_CBE
91.96
64%
-106
- C7 -
-
3SZO
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
22
PsiBlast_CBE
91.91
64%
-108
- C7 -
-
4H4D
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
9
PsiBlast_PDB
91.91
64%
-105
- C7 -
-
4EB3
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
37
PsiBlast_CBE
91.89
64%
-105
- C7 -
-
3UV3
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
1
PsiBlast_PDB
91.88
64%
-105
- C7 -
-
4H4C
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
46
PsiBlast_CBE
91.85
64%
-105
- C7 -
-
3KEF
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
60
HHSearch
91.84
64%
-108
- C7 -
-
4H4D
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
-
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
41
PsiBlast_CBE
91.83
64%
-104
- C7 -
-
3KEM
2
ISPH_ECOLI
B:
[11-320]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
21
PsiBlast_CBE
91.83
64%
-105
- C7 -
-
4H4E
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
15
PsiBlast_PDB
91.83
64%
-104
- C7 -
-
3UTC
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
51
PsiBlast_CBE
91.80
64%
-105
- C7 -
-
3SZU
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
19
PsiBlast_PDB
91.79
64%
-102
- C7 -
-
3UV7
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
14
PsiBlast_PDB
91.76
64%
-105
- C7 -
-
3URK
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
48
PsiBlast_CBE
91.69
64%
-106
- C7 -
-
3KE9
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
5
PsiBlast_PDB
91.67
64%
-104
- C7 -
-
3ZGN
2
ISPH_ECOLI
A:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
54
PsiBlast_CBE
91.54
64%
-107
- C7 -
-
3T0F
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
D
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
23
PsiBlast_CBE
91.52
64%
-104
- C7 -
-
4H4C
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
6
PsiBlast_PDB
91.51
64%
-99
- C7 -
-
3F7T
2
ISPH_ECOLI
A:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
45
PsiBlast_CBE
91.48
64%
-106
- C7 -
-
3KEF
2
ISPH_ECOLI
B:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
36
PsiBlast_CBE
91.47
64%
-105
- C7 -
-
3UV6
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
8
PsiBlast_PDB
91.47
64%
-100
- C7 -
-
3SZO
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
49
PsiBlast_CBE
91.46
64%
-105
- C7 -
-
3KE8
2
ISPH_ECOLI
B:
[11-320]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
17
PsiBlast_PDB
91.45
64%
-101
- C7 -
-
3UV3
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
43
PsiBlast_CBE
91.43
64%
-106
- C7 -
-
3KEL
2
ISPH_ECOLI
B:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
18
PsiBlast_PDB
91.37
64%
-103
- C7 -
-
3UV6
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
16
PsiBlast_PDB
91.37
64%
-101
- C7 -
-
3UTD
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
2
PsiBlast_PDB
91.35
64%
-102
- C7 -
-
4H4D
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
3
PsiBlast_PDB
91.34
64%
-104
- C7 -
-
4H4E
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
55
PsiBlast_CBE
91.24
64%
-107
- C7 -
-
3T0G
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
56
PsiBlast_CBE
91.12
64%
-107
- C7 -
-
3T0G
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
47
PsiBlast_CBE
91.10
64%
-104
- C7 -
-
3KE9
2
ISPH_ECOLI
B:
[11-320]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
V
-----
42
PsiBlast_CBE
91.08
64%
-104
- C7 -
-
3KEM
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
4
PsiBlast_PDB
91.02
64%
-101
- C7 -
-
3ZGL
2
ISPH_ECOLI
A:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
53
PsiBlast_CBE
89.99
64%
-118
- C7 -
-
3T0F
2
ISPH_ECOLI
B:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
------
T
M
G
Q
-----
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
-----
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
------
61
HHSearch
76.17
40%
-103
- C7 -
-
4N7B
2
?
A:
[221-532]
--
I
L
Y
L
I
N
P
R
G
F
C
K
G
V
S
R
A
I
E
T
V
E
E
C
L
K
L
F
K
P
P
I
Y
V
K
H
K
I
V
H
N
D
I
V
C
K
K
L
E
K
E
G
A
I
F
I
E
D
L
N
D
V
P
D
G
H
I
L
I
Y
S
A
H
G
I
S
P
Q
I
R
E
I
A
K
K
K
K
L
I
E
I
D
A
T
C
P
L
V
N
K
V
H
V
Y
V
Q
M
K
A
K
E
N
Y
D
I
I
L
I
G
Y
K
N
H
V
E
V
I
G
T
Y
N
E
A
P
----
H
C
T
H
I
V
E
N
V
N
D
V
D
K
L
N
F
P
L
N
K
K
L
F
Y
V
T
Q
T
T
L
S
M
D
D
C
A
L
I
V
Q
K
L
K
N
K
F
P
H
I
E
T
I
P
S
G
S
I
C
Y
A
T
T
N
R
Q
T
A
L
N
K
I
C
T
K
C
D
L
T
I
V
V
G
S
S
S
S
S
N
A
K
K
L
V
Y
S
S
Q
I
R
N
V
P
A
V
L
L
N
T
V
H
D
L
D
Q
Q
I
L
K
N
V
N
K
I
A
L
T
S
A
A
S
T
P
E
Q
E
T
Q
K
F
V
N
L
L
T
N
P
P
F
N
Y
T
L
-----
Q
N
F
D
G
A
H
E
N
V
P
K
W
K
L
P
K
N
F
L
H
M
I
K
E
-
57
PsiBlast_CBE
75.04
40%
-106
- C7 -
-
4N7B
2
?
A:
[222-526]
---
L
Y
L
I
N
P
R
G
F
C
K
G
V
S
R
A
I
E
T
V
E
E
C
L
K
L
F
K
P
P
I
Y
V
K
H
K
I
V
H
N
D
I
V
C
K
K
L
E
K
E
G
A
I
F
I
E
D
L
N
D
V
P
D
G
H
I
L
I
Y
S
A
H
G
I
S
P
Q
I
R
E
I
A
K
K
K
K
L
I
E
I
D
A
T
C
P
L
V
N
K
V
H
V
Y
V
Q
M
K
A
K
E
N
Y
D
I
I
L
I
G
Y
K
N
H
V
E
V
I
G
T
Y
N
E
A
P
H
C
----
T
H
I
V
E
N
V
N
D
V
D
K
L
N
F
P
L
N
K
K
L
F
Y
V
T
Q
T
T
L
S
M
D
D
C
A
L
I
V
Q
K
L
K
N
K
F
P
H
I
E
T
I
P
S
G
S
I
C
Y
A
T
T
N
R
Q
T
A
L
N
K
I
C
T
K
C
D
L
T
I
V
V
G
S
S
S
S
S
N
A
K
K
L
V
Y
S
S
Q
I
R
N
V
P
A
V
L
L
N
T
V
H
D
L
D
Q
Q
I
L
K
N
V
N
K
I
A
L
T
S
A
A
S
T
P
E
----
Q
E
T
Q
K
F
V
N
L
L
T
-
N
P
P
FNY
T
L
Q
N
F
D
G
A
H
E
N
V
P
K
W
K
L
P
K
N
F
-------
62
HHSearch
72.33
31%
-122
- C7 -
-
3DNF
2
ISPH_AQUAE
B:
[2-282]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
-
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
-
C
N
G
K
G
I
V
V
E
T
L
E
D
I
G
E
A
--
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
C
------------------------------------
58
PsiBlast_CBE
71.25
32%
-117
- C7 -
-
3DNF
2
ISPH_AQUAE
B:
[2-280]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
G
I
-
V
V
E
T
L
E
D
I
G
--
E
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
--------------------------------------
59
PsiBlast_CBE
70.12
32%
-118
- C7 -
-
3DNF
2
ISPH_AQUAE
A:
[2-280]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
G
I
-
V
V
E
T
L
E
D
I
G
--
E
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
--------------------------------------
81
Fugue
58.01
32%
-8
- C7 -
-
3DNF
2
ISPH_AQUAE
A:
[1-281]
M
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
-
C
N
G
K
G
I
V
V
E
T
L
E
D
I
G
E
A
L
K
--
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
--
E
V
K
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
-------------------------------------