@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRV3: (2017-12-04 )
MPELPEVETTKTSLFPLLNQKVLSVEVRNPSLRWPIPDNVQKLVGQRLIGLNRRSKYILAEFEQDQMLWHLGMSGSFRLCQPNDELRKHDHLIIQFEDQQLRYHDPRRFGCILWLNPETQGKLIDTLGPEPLSTDFHAEYLASKLKNKSVGIKIALMDNHVVVGVGNIYATESLFNVGIHPAQPAGDLTMQQIEKLVVEIKRILKSAIDLGGSTLRDYSNAMGENGYFQQTLLAYGRAREMCVNCETTLENLKLGQRASVFCPQCQPLKKLRKP
Atome Classification :
(20 SA)
.........10.....-..-.20..-..-....30.-..-.-....40-.........50........60...-.....70........80........90.-......-.100.......110...--....--120.--......130.......140.......150.......160.......170.......180.......190.......200.......210.....--..220.......230.......240.......250.......260.......270..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPELPEVETT
K
T
S
L
F
P
-
L
L-NQ
K
V
L
-
S
V
-
E
VRNPSL-RW-P-I
P
D
N
V
--
Q
K
L
V
G
Q
R
L
IGLNRRS
K
Y
I
L
A
EFEQ-D
Q
M
L
W
H
LGMSG
S
F
R
LCQP
N
D
E
L
RKHD
H
L
-
I
I
Q
FED-QQLRYHDPR
R
F
G
C
I
L
W
L--NPET--QG
K
L
--
I
DTLGPEPLS
T
D
F
H
A
E
Y
L
A
S
K
LKNKSV
G
I
K
I
A
L
MDN
H
V
V
V
G
VGN
I
Y
A
T
E
S
L
F
NVGIHPAQPAGD
L
T
M
Q
Q
I
E
K
L
V
V
E
I
K
R
I
L
K
S
A
I
DLG
G
S
T
L
R
D
--
Y
S
N
AMGENG
Y
F
Q
Q
T
L
L
AYG
R
A
R
E
M
CV
N
C
E
T
T
L
E
N
LKLGQRASVFCPQ
C
Q
P
L
K
K
LRKP
104
Fugue
72.49
46%
3
* C8 *
-
1K82
3
FPG_ECOLI
A:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
-
H
L
V
G
A
T
I
L
-
H
A
-
V
V
R
N
G
R
L
-
R
W
-
P
V
S
E
E
I
Y
--
R
-
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
E
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
-
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K--
E
L
E
--
G
H
N
V
--
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
----------
K
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
-------
1
PsiBlast_PDB
71.94
44%
6
- C8 -
-
1K82
3
FPG_ECOLI
A:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
-
G
A
T
I
L
-
H
A
-
V
V
R
N
G
R
L
-
R
W
-
P
-
V
S
E
E
I
--
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
P
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
-
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
--
K
E
L
E
--
G
H
N
V
--
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
--------
22
PsiBlast_CBE
71.37
44%
4
- C8 -
-
1K82
3
FPG_ECOLI
C:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
-
G
A
T
I
L
-
H
A
-
V
V
R
N
G
R
L
-
R
W
-
P
-
V
S
E
E
I
--
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
P
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
-
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
--
K
E
L
E
--
G
H
N
V
--
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
--------
21
PsiBlast_CBE
71.21
44%
3
- C8 -
-
1K82
3
FPG_ECOLI
D:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
-
G
A
T
I
L
-
H
A
-
V
V
R
N
G
R
L
-
R
W
-
P
-
V
S
E
E
I
--
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
P
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
-
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
--
K
E
L
E
--
G
H
N
V
--
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
--------
13
PsiBlast_PDB
70.96
36%
12
- C8 -
-
2F5S
2
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
23
PsiBlast_CBE
70.76
44%
3
- C8 -
-
1K82
3
FPG_ECOLI
B:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
-
G
A
T
I
L
-
H
A
-
V
V
R
N
G
R
L
-
R
W
-
P
-
V
S
E
E
I
--
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
P
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
-
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
--
K
E
L
E
--
G
H
N
V
--
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
--------
20
PsiBlast_PDB
70.20
36%
10
- C8 -
-
3GQ4
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
19
PsiBlast_PDB
70.18
36%
10
- C8 -
-
3GPY
2
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
105
Fugue
69.80
38%
-6
- C8 -
-
1EE8
-
FPG_THET8
A:
[1-266]
-
P
E
L
P
E
V
E
T
T
R
R
R
L
R
P
-
L
V
L
G
Q
T
L
R
-
Q
V
-
V
H
R
D
P
------
A
-
R
Y
R
N
T
--
A
L
A
E
G
R
R
I
L
E
V
D
R
R
G
K
F
L
L
F
A
L
E
G
G
V
E
L
V
A
H
L
G
M
T
G
G
F
R
L
-----
E
P
T
P
H
T
R
A
-
A
L
V
L
E
G
-
R
T
L
Y
F
H
D
P
R
R
F
G
R
L
F
G
V
RR
G
D
Y
R
--
E
I
P
L
--
L
L
R
L
G
P
E
P
L
S
E
A
F
A
F
P
G
F
F
R
G
L
K
E
S
A
R
P
L
K
A
L
L
L
D
Q
R
L
A
A
G
V
G
N
I
Y
A
D
E
A
L
F
R
A
R
L
S
P
F
R
P
A
R
S
L
T
E
E
E
A
R
R
L
Y
R
A
L
R
E
V
L
A
E
A
V
E
L
G
G
S
T
L
S
D
QS
Y
R
Q
P
D
G
L
P
G
G
F
Q
T
R
H
A
V
Y
G
R
E
G
L
P
C
P
A
C
G
R
P
V
E
R
R
V
V
A
G
R
G
T
H
F
C
P
T
C
Q
G
----
E
G
P
12
PsiBlast_PDB
69.52
36%
13
- C8 -
-
2F5Q
2
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
40
PsiBlast_CBE
69.21
36%
14
- C8 -
-
3JR5
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
10
PsiBlast_PDB
68.94
36%
17
- C8 -
-
1R2Y
2
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
38
PsiBlast_CBE
68.64
36%
-0
- C8 -
-
3U6D
2
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
66
HHSearch
68.63
44%
4
- C8 -
-
1K82
3
FPG_ECOLI
B:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
-
H
L
V
G
A
T
I
L
-
H
A
V
V
R
N
-
G
R
L
-
R
W
---
P
V
S
E
E
I-
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
P
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
-
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
--
K
E
L
E
--
G
H
N
V
--
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
I
E
Q
G
G
T
T
L
K
----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
R
V
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
-------
6
PsiBlast_PDB
68.42
37%
15
- C8 -
-
1L2D
2
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
----------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
65
HHSearch
68.34
37%
19
- C8 -
-
1R2Y
2
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
V
G
K
T
I
E
-
D
V
R
I
F
W
P
N
I
I
-
R
H
P
R
-
D
S
E
A
F
A
-
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
AD
R
R
P
P
--
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
-------
11
PsiBlast_PDB
67.99
36%
16
- C8 -
-
1R2Z
2
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
--
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
18
PsiBlast_PDB
67.97
37%
2
- C8 -
-
3GQ5
4
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
25
PsiBlast_CBE
67.62
37%
3
- C8 -
-
3GP1
2
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------
33
PsiBlast_CBE
67.60
36%
4
- C8 -
-
3U6P
2
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
-
L
I
-
V
G
K
T
I
E
D
V
-
R
I
F
W
P
N
I
I
R
H
-
P
-
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
-
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
--
A
K
E
E
--
A
D
R
R
PP
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
R
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
--------